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N ESTASLISHED 17190 CI GARETTE3^- TO E3ACCO LORILLARD BUILDCNG CABLE ADDRESS~"LORILLARD " NAY 0 8 18&3 May 6th, 1963 Dr. C. 0. Jensen Research Supervisor Greensboro Branch Greensboro,N. C. Dear Dr. Jensen: We are enclosing copies of two tables which Drs. Homburger and Bernfeld left with the writer when they were in our office last Friday. The data in one table satisfactorily establishes a stronger dose response relationship between phenol in KENT smoke and mucus flow. The other table presents new data on the smoke from three brands of cigarettes, particularly that from Larks. We realize that neither you nor Dr. Schultz will be happy with this latest data. Very truly yours, HBP:SS H. B. Parmele, Ph.D. Enc. Vice President Director of Research

< Effect of phenol at various concentrations on the ciliary mobility, in the preaence of smoke from Kent cigarettes (9 puffs of 35 ml each) C Mobili ~ Exposure Number of Standard Deviation to phenol Frogs Used Mean values of the Means t 0~ 25 0.405 0.045 0 3 15 0.455 0.151 25 20 0.435 0.184 60 20 0.460 0.138 90 16 0. 420 0.132 115 18 0.340 0.131 165 16 0.325 0.084 215 16 0.340 0.095 t in nine puff s *) Control I, in the presence of smoke from Kent cigarettes +) Control II, " 11 rr tt ts fr u rt ~ Ratio - of mucus flow after exposure to mucus flow rates before exposure

Effect of $nxoke from different types of cigarettes on the mucus transport rate of frog esophageal cilia C ilia Mobdli *) Number UM of Cigarette V'aluss_ Standard lleviatio I _ of the Means of B"ro8.s Used I'sll Mau 0.245 0.050 5 Kent 0.340 0.087 20 Lark 0.480 0.118 20 Air Control 0.750 0.122 12 e) Ratio of mucus flow rate s aite r mxpo sure, to mucus flow rates of the sarna tissue preparations before exposure.