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, A `~ A Division of' ILoevNs Theatres, Inc., Research Center, 4201 English Street, P.O. Box 21'688, Greensboro, Nbrth Carolina 27420! .M March 31, 19'8'3 Dr. Carol J. Henry Microbiological Associates 5221 River Road' Bethesda, MD' 20816 Dear Dr. Henry: We are enclosingisigned Protocol 160'1.00i5, Experiment Number I-1'7'2'91.005: Six Week Repeated Smoke Inhalation in Mice to Compare Histopathology and Short-Term Endpoints Using Test and Reference Cigarettes.. We have reviewedthe D'raft Final Report for Experiment rilo.. 1-1725.013: The Effect of Inhalation of Reference and Test (D3 and D4)i Cigarette Smoke on Two Cytogenetic Endpoints in Mice: Chromosome Aberrations and Sister Chromatiid Exchange, and have these comments and questions. 1. Onpage:2,p~aragraph4,firstsentence: commasshou~ld appear after the words "proliferating" and "produced'." No other punctuation is necessary. 2'. On page 3, under Data With Human Smokers, line 6: SCE is abbreviated here for the first time in the text of the report. The words "'Sister Chromatid EXchange" should appear here to def:ine the abbreviation. 3. On page 10, line 2£rom the top: the text should read "and resuspended." 4. On page 10, under Sister Chromatid Exchanges, paragraph 1,, line 7: the text should read '11P at 1 mg/'kgl." 5. Same paragraph as #'4'above, line 19: the text should read. "and resuspended." 6. On page 11, first line: the text shouldlread "or show signs." 7. On page 11, the semicolon should!be added after Chromosome Aberrations. 8. On page 12, paragraph 3, line 10.: the animal number should be 86 8'.

Dr. Carol J. Henry March 31, 1983 Page 2 9. On page 12, paragraph 5, line 6: statistically is mis- spelledi. 10. On page 13, under Sister Chromatid Exchange, line 3: individual is misspelled. 11. Same paragraph as #10 above, lines 1©-12: the text states that the treatments were statistically increased above the background rate. Table 6 does not note the significant increases. 12. On pag;e 14, Table 1': there should be a space between groups 4 and 6. If you have any questions, please feel free to call. Sinc ,9~rely, NVW-e Connie J(;/ Stone, Ph.D., D.A.B.T. /tb:2 Enclosure