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f A Division ofi Loews Theatres, Inc., Research Center, 420 English Street, P.O. Box 21688, Greensboro, North Carolina 274201 ' January 27, 1983 Dr. Carol J. Henry Microbiological Associates 5221 River Road Bethesda, MD 20816 Dear Dr. Henry: We are enclosing the following signed protocols: 1. Protocol 1601.005 (Experiment No. I-1726.005): Six Week Repeated Smoke Inhalation in Mice to Compare Histopathc1logy and Short-Term Endpoints Using Test and Reference Cigarettes. 2. Protocol 1601.006 (Experiment No. I-1726.006): Six Week Repeated Smoke Inhalation in Rats to Compare Histopathology and Short-Term Endpoints Using Test and Reference Cigarettes. 3. Protocol 1601.013 (Experiment No. 1-1725.013),: The Effect of Inhalation of Reference and Test Cigarette Smoke on Two Cytogenetic Endpoints in Mice: Chromosome Aberrations and Sister Chromatid Exchange. We have already sent to you in our letter of 1-14-83 a list of corrections for Protocol 1601.013. The following is a list of errors found in Protocols 1601.005, 1601.0016, or both. 1-1726.005 and I-1726.0106 1. On page 1, under 2.1, line 6: the date of the "Walker et al.°' reference is 1978, while in the bibliography section, it is 19 8' 1. 2. On page 1, under 2.1, line 15: a comma should be placed after "epithelium". 3. Same section, line 19: metaplastic is misspelled. 41. On page 2, under 2.2, last line: the text shou~ld read total protein levels." "or -I 5. On page 2, under 2.4.1, line 1: the abbreviation shouldibe U1 ~~AHH" .

Dr. Carol J. Henry January 27, 1983' Page 2 6. On page 3, under 3.2: the correct P.O. Box is 21688. 7. On page 7' (16,01.0,05) or page 6('1601.006), under 8.2, line 3: the text should read "were determined previously." 8. On page 11 (1601.005) or page 10 (1601.006), paragraph 2, line 1: the paragraph.shouldibeg,in with "The trachea" or "'Tra- cheae". 9:. On page 12' (1601.005) or page 10 (1601.006), under 9.6.1(1): the "Schwartz et al." reference has no corresponding entry in the bibliography section. 10. Same section as tt1 above, line 18: predominantly is misspelled. 11. In.Appendix 1, paragraph 1, lines 3 and 16: cigarette is misspelled'. 12. In Appendix 1, paragraph 1: these four references have no corresponding entries in the bibliography section: Welch et a1., 1968; Cantrell et al., 1973; Akin and Benner, 1976; and!Holt and Keast, 1973. 13. In Appendix 1, paragraph 1, lines 12-13: the text should read "such as AHH reflects inhaled ..." 14. In Appendix 1, paragraph 1, line 19: the text should read "but not liver AHH. . ." 15. In Appendix 1, paragraph~2: antipyrine is misspelled. 1-1726.005 1. On page 2, second complete paragraph~: the comrna:following "evaluation" should be omitted. 2. On page 5, under 7.1.1: biycoplasma is misspelled. 3. On page 14, paragraph 3: colorimetric is misspelled. I-1726.006 1. On page 5, under 7.1.1, line 5: should the text read "pneumo- nia virus of mice"? 2. On page 8', under 9.3, line 7: the word mice should replace rats.

Dr. Carol J. Henry January 27, 1983' Page 3 3. On page 10, paragraph~l, line 4: a comma should be placed after "'adMinistered°. 4. on page 12, a statement concerning additions or substitutions is included after the list of blood chemistry values. Why does this statement appear in:the rat protocol, but not in the mouse? 5. on page 13, paragraph 2, line 6: a"'by" should be omitted. 6. On page 14, under 11.0: "TESTD" should be omitted from the title. If you have any question~s, please feel free to call. /lwt:1