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Appendix Distribution Coefficients of Nicotine Between Water and Organic Solvents 12 K = C/C' where C represents the concentration of nicotine in the aqueous phase and C', the concentration of nicotine in the organic phase, both in grams per liter Distribution Coefficient,C/C' , at Solvent 10°C 25°C 40PC Chloroform 0.016 0.013 0.008 Ethylene dichloride 0.104 0.068 0.057 Undecanol 0.154 0.082 0.062 Chlorobenzene 0.147 0.083 0.053 a-Dichlorobenzene 0.159 0.093 0.057 Benzene 0.187 0.104 0.075 Carbon tetrachloride 0.193 0.116 0.074 Nitrobenzene 0.223 0.124 &.117 Toluene 0.243 0.137 0.079 1,4-Dichlorobutane 0.208 0.142 0.642 p-Cymene 0.214 0.148 0.133 Butyl acetate 0.382 0.166 0.121 Xylene, A.C.S. 0.338 0.181 0.234 Dichloroethvl ether 0.251 0.181 0.689 sym-Tetrachloroethylene ... 0.181 0.107 Cyclohexane 1.160 0.557 0.268 n-Heptane ... 0.942 0.526 Kerosene ... 1.11 .... Deobase 2.84 1.25 0.63