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Lorillard

Awareness Bulletin

Date: 17 Sep 1976
Length: 77 pages
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Anthony, A.
Bingaman, D.P.
Richmond, F.
Scott, S.
Skladanowski, L.
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MINI, MINIMUM CODING
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G31
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13 Jul 1999
Litigation
Fali/Produced
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R1-001
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LIBRARY/AWARENESS BULLETINS
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NELE, NEWSLETTER
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axf13c00

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T A Division of Loew's.Theatres, Inc. Research Centn• Library 420 English St...Greensboro, N..C. 27420 Cable Address 'Lorillard' NEW YORK OFFICE 200' E. 42NU ST. FOR COMPANY USE ONLY C4NIEdIS Ir NEWS BRIEFS 940 II'1, SPECIAL FEATURES 956 III, ABSTRACTS FROM CURRENT LITERATURE 968 IVr ANNOUNCEMENTS 1002 V. NEW LITERATURE 1006. PUBLISHER LORILLARD. EDITORIAL.STAFF AUDREE ANTHONY, EDITOR. FRANCGS RICHMOND, COMPILERD. P., BINGNfAN • SARI SCOTT LARRY SKLxD.1NOWSRI. COVER: TOBACCOPLANT WITH FLOWERS DON REDMOND VOLr 6~ NOy 17, SEPTEMBER 17, 1976 ;
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I .: 00009960 A Division ol Lnesvs?hcatres,.iho. WOIL r 6~ N0 t170 SEPTEMBER 17, 11,176 ,•
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I NEWS BRIEFS BUSINESS AND EDUCATION Greensboro Daily News 8/27/76, p. A21 N. Y. FEDERAL COURT, ASKED TO DISMISS SUIT AGAINST.RJR' WINSTON-S:AI:E3S (AP) - The president and chairman of the board of R,J. Reynolds Industtics have asked a federal court in New York to dismiss a stock- , holder's suit seeking to recover money spent on illegal , political contributions and foreign kickbacks. The papersanswering the suit weree filed in U.S. • District Court of Southern New'Yorkby President J, Paul Sticht and board Chairman. Colin Stokes. . ' . Attorneys for the executivess contended that Sticht and Stokes were not involved in making illegal or ques- ' tionable payments which the company has admitted. ; The lawyers alsoo said the court has no jurisdiction in ` the ease, the suit is not in the best interest of Rernolds and :ts shareholders, and lhat the statute of, limiations - hasi eapiredonany illegal acuvities,. - . Four other executives and board memherswere im-' plicated isthe funds following an internal investigation' announccd' earlier this year. T' ree were reassigned and a fourih had Petired. -- - The rompanysaid its executivesdivertedass much as $19t4000.in cnrporate funds fnr illegal purposesin the lc.e 1960s and early 191Os::It said.some nQi000went.to d'omestic political campaigns andatle:ut $100;pW wcntto foreirn officials who may have performed favors for Reynolds. . The suit; was. filed by Stuart'lkechslcr, a New York + tawyer,, on behalfofstnekholderSara Kass. SYechsler;. ,has said onr.purpose ofthe suit.was: too force Renolds to -- divulgee details of the contribationsand recipients. + vOL'r 6o No, 17, SEPTEMBER 17, 1976 TECHNOLOGY C&E News August 30, 1976 Vol. 54, No. 3:6, p. 18' . Xylitol; apossiblydecny-prevenling sugarsubslitule, is being marketed in nmU.S: by Hoi!mann-t-aRoche. Xylitol is analural sugar alcohol (CsH,zOs) obtained Irom birch wood and IccrA in minny, trfruits and!vegeta- ._ . blCS. Il Is.about as sweet as-sucro5e wi:h a pleasant, cool tasle. Finnish sludios sugpest that i1 is much!GSs Ilkelyto cause denYal caries IiLV suGOse&nd may ew:n prevent their lorrnriion: A US: stu?).py the compcurtd's ' ellect on tooth deay is being planned to begin this lag or winler and will be sponsored by the National Lnstitule for rkntalResearch. Hollmann•LaRochewiil minu-lacture xyliml in a joint venture wilh Finn+sh Sugar Co. of Helsinkl at a plant loeatcsl in KoC<a, Finland... 00009977 955 s
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. . NEWS BRIEFS TOPACCO INDUSTRY Greensboro Daily News 9/15/76, p. A7 SEA-LAND FIRM AGREES TO'.$1 MILLION PENALTY : . W-IlVSTON-SALEM'(AP) - Sea-Land Service Inc., the R. J. Reynolds Indus. !.. tries Inc. sAippingsubsidiarywhich has . admitted disbursing more than $19 mil. .lion in "possibly illegal rebates,"-will - ~ agree : to a, settlement with theEederal Maritime Commission involving penat- ` . ties of more than $1 million, a report , tays. . ' The Winslon-Sslem Journal carried . :tlie,report In itsTuesday editions and . quoted knowledgable sources in Was~- ington. . . ;' The repoFtsaid.the agreement will be - the largest swngle settlement penalty in the 15-year history of, the commission and is expected'too be formally aa- nouncedd within two weeks. The settlement will not name the re- cipients of the pavments which open both carriers and the shippers tosanc> tions,.according to~lhe report. I, A number of majorAmericancompa-;. nies, however, areexnected too tell the ' Securities and Exchange.Commission this monththath their employ;ess have been accepting improper payments from 4 ocean carriers, including Sea-Land, the report says. Batt the shippers aree not, telling the SEC the names of thecarriers or the : identities of..their implicated officiats; tF.e report adds. • R. J.. Rey,nolds.Industrfes disclosed ' last week that it and itashipping subsid- y iary made nearlyS25 million iv quection- able payments, Including $190,000 in domestic political contributions, from 1968 lhrough:last year.. Reynolds; a majorr cigarette manufac- turer headquartere& in Winston,Salem, did not diselosae recipients of thee politi- cal contributionss but' said tlfexwere made primarily to congressional and presidential candidates. • ~ . -. ; WOllr 6, NOt 17, $EPTEMBER.I7. 1976 ..~' It saidatha~ more thin $19 million im Sea-Land retiates ment to customers and' ~: shippers througlmut thee world. . It said Sea,Land'd paid111.55 milhon in. . :rebates in connectionn withh its Atlantic. ahipping business, pnnarily in Europe.. .~' Anottier $7 million nas.paid'inPacific! .. operations and the $500,000 balance went imconnection with Caribbeanship-ping, . . .. Greensboro Daily News 8/27/76, p., A21 EASTERN, MIDDLE TOBACCO PRICES UP RALEIGH (AP) - Whileaverage.prices wereupe on twofice-euredo tobacco be(ts inn the Carolinass and' Virginia Thursday, a slight decline was noted on the--South Carolina-Border North Carolina Belt, the Fldcr- al-Slate Market News Service said.. -. ~ 1Pithsalesof 4,318,810 pound§, the-averape w•as~$117:63 per 100pounds.on the Border Belt Thursday,._i a dcCline of eight cents trotn:V~ednesday: Seasnn.safes:•~ reached 144,094,122pounds for an. average of $105.5;. ` The Eastern North Carolina Belt showed the dav's• greatest gain ass thraveraFe went up.81 cents to $114.22' pcrr hvndredweiGht on sales of.6.8&0,320, Senson.sales.n hit t79,9a2,366pounds for an average of $104:60: An inerease. of 61 cents per 10 pnundss was natccD on the Old and Middle Bclt asthe avrragehitSlo8,4t oni sales of.6,5•ti,629. Scason sales reached 117,508.322[ . pounds for. anacerage of $96.88 pt•r hundredlvcight. s 00009964
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0 NEWS BRIEFS HEALTH Greensboro Daily News 9/14/76, p.. A1f1 PANEL: AEROSOL CANS DAMAGING t)Z0NE NASHLiGTON (AP) - The National ' Sciences said Monday that. Academy of .fluorocarbons in aerosol sprays are.dam- aging the earth's ozoneshieidl andmay ltave to be regulated or banned svithinn two years to guard against higher. skin cancer.rates and potentially serious ..elimate changes,, "Selectivesegulation of CF&I (chloroo- ' fluoromethaneror fluorocarbon) uses and. releases is almost certain to be neccs- sary at some. time and to some degree of completeness," said: a new academy report. . ' Two academy panels concluded' that fluorocarbons are,destroying the ozone umbrella high above the earth thatahields out dangerous ultraviolet radia- tion: They said',excessiveradiation could' Incrcase.tl,eratQ of human skin cancers, --depress food production and seriously changee the planet!s climate.. Academy president.Philip Handler - told the FYhite House in a transmittal letter that the rate of ozor.e reduction is relatively small att present and that "a one- ortwo-year.delay in actual~imple- mentation of a ban or.regulaGontcouldnot be unreasonable."' One ofthnpanels recommended, how- eeer, that thegovernment.immedibtely overhaul its.legal regulatory machinery to be prepared for action, and that aero- sol.spray cans containing ftuorocarbonsbe labeled so that consumers.could avoid them~ if they wished. The Do Pont Co.,.the major fluorocar-bon manu[acturer„and'the Aerosol Edu-cation Bureau, which represents the aerosol spray can industry, both ap- plauded the panel's recommendation to delay regulatory decisionss until more studies on the ozone problem have been - conducted."1Se Lhink they made the correcN deci- sion insacing that there isno.significant . rfsk totaking.18'.to 2Dmonttfs for more research," a Du Pont spokesman said. "77tcre! is ongoing,researcii by industry and government to makea.fullerassess~ ment of any possible need for regulation within two scars." The research.iscost- ing up to $2D millioma ycar. VOI, 60 NOt 110 SEPTEMBER 17, 1976 If7egulatory• action proves to be ncc- essary, the panel recommended that the govcrnment first'ban fluorocarbons in . ; most consumer aerosoI,sprays, and im- :- pose controls to prevent release of fluo: ' - . rocarbonsfrmn auto air.conditioners: - Oregon has banned fluorocarbons In aerosol sprays effeetlve March 1,.1977. Aerosol spray cans accounted for 74' ~perr cenfof the nearly 1.55 billlon pounds. . of F-11 and F-12 Du Pont fluorocarbonsconsumed's woridwide last year, the re- portt said. Aerosolized hair sprays and antiperspirant-deodorant sprays alone - consumed.5B' per cent. "The impact on the world oflwaiting a couple of.years before decidine„whether or not to regulate the uses and releases of F-11 _nd F-12 is small a:though we aree uncerdainjust how small," theacad• emy report said. "The impacfon indus. tryof a ban onuses.af F-il or F-12 in most types of.spray cans would be ap• preciable." . . . 00009970 948 5
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b T TOBACCO~ZNDUSTRY .Greensboro Daily News, 9/13/76 STUDY: NEVER TOO LATE' ADULT SMOKERS. GIVEN NEW HOPE COLD SPRINGS HARBOR. N.Y. - A' ' .- new British study shows that longtime cigarette smokers who break the habit ~will drasticallyreduce.the likelihood of- ' suffering a severely disabhng lung dis- - = ease in old age. ~ - ~ ; This finding challenges the conven- ttdnal medical wisdom that a person who stops smoking, in middle age does so too late to.save.himself from chronic obstructive lung disease, a condition in -wiiich the lungs gradually deteriorate. The ailment, which almost neverr kills - nonsmokers, eventualiycauses.thedeath. of alrout..10 per centafregular smokers. Over the years, victims gradually be- come short of breath and unable to walk•unaided.. . Yet a40-year-old person whohassmoked throughout.adulthooC Is"quitelikeiy" never tobecome severely dis- ab'^d by the disease if'.he ,.quils smoking,saidOxford'University biostatistScianRichard Peto. .. The study-said by authorities to be the largest ofitsf kind-involvedtwice yearly thorough checkups from 1961 to. 1969.of792 middle-aged blue-collar and ' office wrorkerss in. London. Peto said that it was nearly impossible - tGget absolutely reliable figures on. how many cigarettes, per day those in the study had smoked. Most, hesaid„ had smoked..about a pack.a day. The Oxford University Press will pube lish next Wednesday in England.a book• length study on chronic 1ung.disease en- titled: "The Natural Historyof Chronic Bronchitis and Emphysema:," The principal,author is Professor Charles. Fletcher of tlieRoyal.Postgrad- uate Medical' School in London. Peto,. a co-author, discussed'.tlte re- sults inan intcniewlast svicekatCold Spring Harbor Laboratory, where lie was attunding an international conference on the origins of human cancer. At the mecting; lie also presented a..new report showing a smokei s risk of getting lung cancer "freezes"'w'hemhe quits, instead _ of tite risk decreasing as widely believed. ;VOILt 6,, NOt 17~ SEPTEMBER 1Ts 1}76 F . ,* The researchersdound that among. . ~~ smokers~s in their chronir.lunn disoase~ •. smny, aoout 2s per cent.had had notauty Impaired lungs by middleage:. For any smoker whose ability to breathe had been reduced, say, by one-third at,age.. 40, he w-ill„if lie.goes on smoking, proba. - bly be severely disabled by age 60, give or take a few years, Pcto said: . •'Aftcr some years of further detorio- ~ tationi hee willi then die," Peto said.. .TObacco. International September 3, 1976 Vol. 178, No. 18, p. 25 N.C. official opposes GAO tobacco proposal ttALEIGH; N.G.-VigOrouS OppGS/- tion has been expressed by tlte. North Carolina. Agriculture Com- missioncr, limGraham; to a.pro- posal by thr. General Accounting Office [o give theDepartmcn[ of.. Hcalth• Education and; 1Velfare. •autliority to rcgulate tobacco. Graham sai&that the GAOpro-posal, is "another skirmish in thisbattle to kill tobacco." He statc& "tlm tobacco industry brings more. than a billion. dollars to the tobac-0o producers of North Carolina: 1willI not sit idly. by. while the anti- tobacco zealots in Washington de- gtruy this vital sc;mcnt-of the North Carolina cconnmv:•" The Ccmmiscinncr callcd on the North Carolina dclction in Con- gress. tm. opposo tbe~ propttsal;, he also.contocicd the State Attorney General, Rufus Ed:nisten: 00009962 s
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NEWS BRIEFS HEALTH Greensboro Record' 9/13/76, p.. Al SCIENTISTS REPORT AEROSOL HAZARD CITED WASHINGTON (AP).-Fluorocar-~ .~ bons from aerosol spray cans have dam--d aged the earthts.protecfiveozone shield .:' and will have tobe selectively regulated or banned, the National. Academy. of . Sciences said today: . . . - But twoo academy panels.which stud- led the problem said anyban orregula- `.` tionof aerosol:spraycans should be delayed one to two. years until comple tion of furtherstudiesonr thee ultimate ' effects of the reduction in the protective shield.of ozone in the atmosphere. .. . Thepanels.said the reduetion.in .~ ozone,, which shields the earth from dan- gerousultraviolet.radiation, could lead .'to increases in skin cancerr and potential- ly great changes in theearth's tempera- ture and climate. . The.reports were designed to resolve - the controversyoverttie relationstiipbe• tween, . fluorocarbons and the earth's ozone layer.. The panels said there was - 1. ;ufficicnt. evideacee to state precisely : the extentt of damage to the ozone sliield.. - • Philip Handler:NAS president,, said in -' a letter to.the White House,^tliat a one on two.ycar delay in actual implementa• - tion of a banor..regulation.would.not be unreasonable:" However, he recotnmended the gov emment begin immediately to eslablish the regulatory machinery that will be necessary to.either reduce the use of . fluorocarbons orhan them completely:. ' The reports said if'fluoroearbons con- tinue too be.released at.19i3levcls;•an ultimate reduction in ozone: of about sev- en perr cent" would result.. Italf.f of this loss would occur in about 50 years, the panels said•. . The panels; expressed' particular con, cern about climate changes thatmightresult.fi'omt a,slipltt reductinn,oCthe pro- tectiveozone: shield. Temperatues could, increase rnearrh: This, in turn, u•outdi' atfect.raintall and'.evaporation nf'mois- ture. "Suchh changes could lead initially toa gencralishift of thecarth's climaticc belts, and ullimately to a, significantt melting of polar ice and a worldwide in- crease in sea level," the reports said. • VOLr 6. NOt 17.. SEPTEMBER'17, I9I6 . I Any weather changes twsenarticular. - . promemss for agriculture:.. • I The reporR stressed that fears of cli?matee changes are only possibilties at'~ present, and that more research iss need- ed before the.effectsofozone reduction! `canbe determined. .. - After hearings and possible revisions„ 'Ithestudies will be submitted toCon. ••'vgress, which is considering legislation to =llmit or ban use of fluorocarbons as,pro. ~pellants in aerosol sprays.andiasrefri-s gerants. . More than 500 per cent of the fluoro- "'carbons produced in lhe United States are used as propeilant in.cans.of deodor.•- ant~ antiperspirant.,, tiairr spray or otherpersonal groomingg products, govcrn-mentt fi3ures show. Stost shaving lather cans do not use fluorocarbons. Advantages of fluorocarbons in aerosoll sprays are they produce a very Cine. ,spray that doei not iecl cold too the skin. Manufact'urers.of items like spray paints generally use other propellants sincethey don't'require the fineness. The ozone conlrovcrsy began in 1974, when. Dcs, \]ario T. 11o1hia and b'rank. S. Rowland of theUnivcrsityof Califor- nia said computer studies.slwwed fluoro- carbons carbons turned into chlorine that destroys ozone. Ozone iss a formm of oaygen~ formed inthe stratosphere, tlu atmospherielayer extcndingfrom 50,000_feet to about'200.,000 feet. Ozone is thinly spread throughout the.laver, but.most conccn• lraled at.SO,000feel: , If it could be compressed into a.blan- ket that covers thee world at.sea lesel,, the entire ozone Ihver in the strato- sphere would be about.one•tcnth of an, inch thi:k.. 00009968
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1 GSEWV BRIEFS. TOBACCO INDUSTRY Business Week 8/30/76 e p. 33 BRITAIN The high cosf of - an ersatz cigarette BrRain'sdrivetodevelopasafer.ciga- tette hasptoved tra.expensi+x for one -. •ofthe eontenders:. Textiles giant . CAUrtauldsl.td bowed outLhis month rather than risk another $5 millioocry- .ing to get apprural foe its tobncco uupp ~ plement-acellul.me mmpmmd-from the government-appoinled Indepen• .!- dent Seientifm Committee on Smoking. & Health (tscsx). After spending 10 . ;~ rears and;1.Bmillion on research and !•development. Courtanldrs decided to .' ., quiCthe.eToti to producewhat many .. Britons are calling "false fags." Prefits -dn the year ended Mar. 31.dropped to '~ jg6A million from E2124' million in 197,i "There are other things we'd r.tberputourtaoney.an('sayxChair- man Sir Arthur. Knight "It seemed aensible to let others go ahead and size up howItnbaeaosupplemenln] get on tommernally." .. - - With Courtaulds out of the.running, _ only. twoeompetltorao remain in the fuAd: Celsnese Corp.. of New York, which lias developed a cellulnsc sule stance that Is already bning marketed by two nilarette makers im..N'est Ger. . many and one in Switrwrland, and New Smoking. Materials Ltd., a joint ven- ture of Imperial' Tobacco Ltd. and Im- perial Chemical' Industrieu. Ltd. The' tmmediate stake is a.market.of 22 'mil- liunBritish smokers, who last year puffed their way through139 billion. ' .. cigarettes, despite the government's . pmpaign.against them. But the ulti-t mate targets are smokers eveq'n'here. Cesuy eaperlments The drive in Britain to deceloptoliaaro supplements . stems largely fmm pressure ftom the Aea1tM tonsricus.gorernmcnt and from antF smoking'gronps. The aim is to find a aubstance.that can be mixed witbto- buece to reduce tar and nicotinewitk out eliminatingthe familiar taste. At)7,ical ersatz cigarette will .vntala Y07<.lo 3rYF of the new supplement,.the companies say. Producing a.safereiRamtte is prov-,. Ing eostly, however. N ew Smoking Ma- terials has spent SL5 million, since 1906 developing its combination of wood pulp and lobacco, whirh it calli. 'xsu:' Celnncse has invested nearly {26.million rescarchieg.and developing a celluloso-based eupplvmentt called Cytrel over the past 1g3'ean: VOLr 6, Not 17, SEPTEMBER 17, 1976 4C~•trel forms part of'the mixture in dgaretleamarketed In West'Germany by British-American Tobaeco Co. and . Martin Brin'amann, buttheyhavenot ' ' raised mueh, smoke, partly beeause.of restrictions on tobacco advertising: In Switzerland,. Laurens Rothmans, part of the South African-based Rothmans International Group, is selling Cytrei- -and.tobaeeo eigarettes, which have - about1.5%oflhemarke4TheCelanese sutstanee has also been bought by .:Britain's'Gallalier Ltd. and Carreras Rothmans, a BritishRothmana aRl- iate„ which plasn to markett cigarettes containingCytrel if its use is approved. - Courtauldv and the remaining con- lendem a!rexdy have spent millions of dollars on tests using mts, mice, dogs, andd humans. Tests with :rs4 ahowthat there is less riskof getting cancer from thesupplhmentalhao from tobacco. But the expenditure is likely to grow substantially heforethe isUSU-also known ass the Hunter Committee- makes a ruling late this fall. Says Bar• ' . tie R. Haiey, New SmokingMaterial'a marketing manager. "Them is atncit'understanding.that success before.thiseommittee is absolutely requircd be• foroother.eountries will take similar movea" . , a' 0 r
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Y tlEWS BRlEFS .. BUSSN'ESS' AND. EDUCATION Greensboro Dai1y' News 3/14/76, p. 4 . . THE REYNOLDS DISCLOSURES R.J. Reynolds Industries' disclosure last weekend that it has made at least $25 mil- llon in questionable payments in the Unit- ed States and abroad places the giant R!inston•Salpm tobacco conglomerate in select company. . : The disclosure is believed to be one of the largest yet filed with the Securities and Exchange Commission under its vol- t untary' admission program. Only Exxon Corp. and Lockheed Aircraft Corp. have so far publicly conceded payments of this magnitude ormore - mostlyy in the form of "gifts" to foreign officials: It is, news of the Lockheed payments which have lately rocked the governments of'Japan, the Netherlands and, most' recently, West Germany. Measured against the Lockheed yard= stick, the Reynolds payments are so far less spectacular in nature: But that makes tltc:n of nnless concern to eovernment inr vestigative authorities. The bulk of the payments - about $19 million between 1971, and,1975, by compa- ny estimates - was made in the form of rebates. by the Reynolds:owned shipping -subsidiary, Sea-Land Service. The rebates are commonly used in worldwide shipping trade as a kickbacks to,shippers and other agents. In most forcign'couutries such rebates are. not,illegalt ln the United States„ how- ever, they are outlawed by the Shipping Actaf 7910.,ThatSea-Land considered the paymenis clandestine is confirmed by the fact that tlie money was paid, according to the company, from "off-book funds" and "mislabcling,of accounts." That is an- other way o6 saying the rebutes cvr•re laun- dered to. escape scrutiny by authorities. That the authoritics are taking the wide- spread rebaie practice seriously is conr firntcd by Reyaolds' further admission that Sea-Land and the,U.S. 1laritinrc.Com~ mission; arc currently negotiating a settlN ment which will'l involve "aa substantial civil penalty and possible other sanc- tions." P:hcthcr rrietiuul laws have also been violated is less cli•ar: A New Jersey VOL. 6, No, 17~ SEPTEMBER 17, 1976 grand jtuy is currently investigating the whole shipping rebate phenomenon. , Though the amount of money involved a is much smaller, Reynolds' companion disclosure that it paid'$t9o,000 ia.disguised political contributions to domestic' con- gressional and presidential campaigns should be of grave concern to corporate official's and investigating authorities. Which campaigns or candidates benefited from the Reynolds largesse have not been identified. A fulDinvestigat9on for possible criminal liability and a further, detailed accounting by the company should'.be-ih order. As for the more general'question of cor- porate accountability, the waters are inev- itably murkier - as they are in alG such cases of following what appears to be the norm in the international profits sweep- stakes. In its defense, Reynolds notes that it did make these disclosures voluntarily; that it did stop the shipping rebates when corporate headquarters said it learned of them in.1975; that Sca.Land did try to dis- courage thc rebate system before suc- cumbiug to inevitable pressures; and that all such payments in the future will be stopped. In addition, the company an- nounc•ed last `Iay that three hi;h oiticiBls had been demoted - though not dis- missed - fortt:eir involvement in the dis- tribution of: political contributions. For thesesteps the company should be commcndcd'. Nonetheless thcv do not ex- ptain away what' appears to be a pattern of fiscal malfeasanco and cover-up. The fact that more than 200 other companies have filed similar disclosures with the SEC makes, the pavments no less disturb- ing.. In othcr counries, for esamplc; dis- closure of the Lockheed.paymenls has already disgraced a rocal prince and led to crlminal indictments againstt a former head of state. Inihis cuuntiy congression- al, SGL': and IRS investigationscont'unue; and! nearly everyone is agreed that the laws shu ild be rcwrittcn Inforeclosesuch miissiva exchunges of, bribes and gifts in tltr future. e
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SPECIAL FEAFUR1E'_`S' TOBACCO INDUSTRY desorption data for the lamina, Ordy, of thcse same Icaves. } Subtracted thee lamina data from the whole-leaf data to obtain sorption and desorption data for ihe midrib. 4 Then "fitted" the mathe- matical models (equations 121 and-[3f) to the data.by'dcterminir.g the value of the difYusion, cncfficient. D, that minimized the difference bo- twxen predicted and observed vaiuer Uf.B(I). The following lerelsofs variables weleeho9Cn: - The test units cronsisted of 12 single tobacco planta.of Burley variety 21. The whole leaf tests were made - with the'e leaves on thee stalk. To acoomplishthese tesu, we crorted' the stalk with paraffin. Thesplite in tFx base off the stalk (made att harvest in placing the stalks on a'stiekfor.handling andin:r.ug) was'..nvered' colnp)etely with Inas6ing tape,. aud'. the tapc was rorercd .ish paraf f in.. After wnc complctedd the wholee leaff tests,. we removed the leaves from:he stplk, coa:rd rhe midribswithparaffin, and'd positirnledt)le leaves on a wtire for the laminaa testss att about thasame sry.acing as',theyhad'y been, on the planl..lacmoval ol'thr leaves from the st:dk wasneces9arybecause the croalinp processs necessi-tated that'.the leaves,.when attached, to the stalk, be moved and bent, a procedure which caused craeks in. thee paraffin. Whcnn the laasess werr, femovedd from the stalk, easy access's was afforded to'hnllr sidcsof th.re midrib. The parafnn' coatingg wass applied heavily to both sides; not't onl,vto provide a moisture barr)er, but also to.provide structural rigidity to present'the paraiiin fromsracking. A'A sketch of the wvll+insulated chamber built for thce sorption tests is shmvn in Fig. 11. The dn' bulb temnentnre x s controlled' to within 2 0.6 °C. Asmall, tan provided mntihuous.air Iftr.v over the tobaecoand the,salt pans. A constant airvelncity was utainlaincl througbout the tests since re5ultr of prel11111hary experimcnls silowedd that sorption i -l.'a. -~ R1G. 1 Srtiem.ue ef d'umbv bnnl fw rurpU°~lela ratess were' not affcctedd byvariarion in air f)owrates. ti''e'e placed about 19 I of salt solutinn in )f pans so that. 2.3 mt of liquid sr.:'facc would be ezposedd to the circulating air. The surface ama of the solution duringg all testss was adequate to replace sorNcd moisture as. moni- tored byw•et bulhthermacouplcs above and below the'e test seclion of the sorption chamber. The salts used were sodium chloride, potassium chloride and potassium sulphale which provided relative humidit9es of 75, 8i-F8, and 97-98'8 percent. respectively. The equilibrium mois- ture contents used inn calculations for the sorptiom, and desorption tests (Waltun 1974) are.shown in'Tab',e 1. We usad.four A54.g.load cells to monitor specimen w^cightt in the sorption clmmbcr. The combined TAULE t. r.0U11.1nR10N MOISTUnE CONTEYTS (nnT 66a15b UsIJn.19 c..r.cuLwnaS\fQII rplen/:.Yf11/fT1 V.Y w\n ~VnPTI V VrlSt%' T.mprumre.~E _ Ileduv~liumimtY.pnnnt Oc,nryuun 90_,pl.°n ll ra afsa 9r-9a E~nlnbn.m muntme eont.nt N.u.l. pne.nt la aA 9L9 laJ ra.U. ss.ea.o ao.e as.a ioo rl 9.e 90.r sU.a 62 .0: 00009983 VoLt 6, Not 17, SEPTEMBER 17, 1976 961
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SPECIAL FEATURFS' TOBACCO INDUSTRY determined byprdiminary expcri- ments(Wallon 19N): 1 The transferr of moisture di- rectly between midrib and lamina during sorption and desorption is negligible. 2. The transienft thermal period of the laminaa and midrib is neclig- WICe as . eomparcd with thee transient . moismreperiod. 3. For airRows.s used in sorption and desorption lests., the externall tesistanee to moisture movement is.s negligible compared to, the internal~ resistance. . Theec gmeming equation wass the vapor diffusion equation (Walton. 1974), which, by use:ofassumptiom 3.reducedto:, a6 al where D = diffusion ccefficient based. an the mass off water per unit mu; of solid, em'/sec Ms'srr t = time,see M = moisture contensat time.q, dry basis, percent lste. =m equilibrium moisture con-, tont.percent Mo= Initial moisture eontent,. percent The results of the preliminary ex- periments periments (Walton 197i)greatl,vsim-) pliflcd.the boundary conditions. Thee malhematical'l consequence of thee negligibility of external resistance to moisture noww as compared with in- ternal'.resistanee was thah theconvee-tive mass transfee corfLcientt wascansidcred to be intinile. Our physi-eal interpretation was that the surfam" of the tobacco leaf instanuneunslr. reaehedd equilibrium widn its unviron-. mcnt.. Thcrcforc... our problem' was. • reduced to thc solution nf the dilt-u-sinn equationn for the infinite thin sbeet and fur tliee infmitelv long circular cylindc4. with a buundarxeondition thau thre leaf surtace in- stantaneousl¢ rcacha equilibriumm with ilss envirunment. lltc ihilial, condition wass that.n:idrib a ndlami na, were initially at a uniturm muiaure.d conlent, b1o,. We followed'thed metlsods of Frank (s9bi) tn,dcannine the cnrrc.panding solutions lot Ilm.e lamina and midrib. VOLr 6, N0lt 17, SEPTEMBER'.II, 197& Iaminatlfodel The mathematical model for the average nmisluree content of the laminaas aiunction of time is: ] B (q • eDaet1. a' .141 •o,s~Lts . where 21, rsmpsr.m,..twepuon.ne ~awtruom....... .ta.la,a..ed a.'c smprmn.eune. h„mim................. .te: ereai at.as Desoepnon..re4n.el.unuNlY ................. ...N Pleent cumpun.m... .. . ....... ..... .... . Wnw-mie.e,Dirtetino ot' mni.wre ne+ ............. wrpnpp, A'ewrpuc+. ....tnur. Humarv or repnc............................... n = 0.1,2..,.. L = halfthickness of thmlamina, Cox hUddb Model The mathematical niodel for the average ntoisture content of thc midrib.as a function of time is: .Z R ..Danxt B (I)- ; L]I where pn = nth positive root of 10((1 nR) = 0 Io(pnR) = Ressel function of order zero R = Radius ofmidrib• cm The exponentiapl equation was used ass the standordd of comparison in evaluating the validityy of equations [2) and (7j:. ............. lcl where k = an absorption constantp Ar' EYYCRI%l1TNTAL PROCEDUItE. Wee developed e.pcriinental tcch- niqucs tn dmcrmine sorption and dcsorption oCthe.lemina and midrib wilhout' separating, the components.. In the proccdurc, we 1 Uctcrmiimdd the sorption and dcsorption data tor whole burley leaves. 2 Ihteaninedthe sorpti6n and 00009982 .
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r 0 NEWS BRIEFS TOBACCO' INDUSTRY' Vol. 178, No. 15:, p. 21 Tobacco Internat'iional September 3, 1976 FTC accusations ,:.draw fire ffom: RJR. ._ WASHINGTON, o.c:-In. October,: 1975,.the Federal TradeCommiv sion filed civil penalty complaints - six leading; American against the `.. tobacco companies, charging vi- - - olations of oonsent.orders, agreed' too in. 1972; requiiing a health: . ,'warning.in all cigarette advertisin e. InJuly, 1976, the.FTC madefur-- ther allega8ons, adding to the . complaint. - I R.J. Reynolds, Inc., the largest of the accused tobacco companies,. .. replied. that in th•.se actions:. the FTC seeks. "potentiallyminousy penalties" and is "simultaneouslyrewriGng the.terms of.the consent ordcr'of 1972. Accordingg to AdvertisingAgc(August 9, 1976) RJR filed aa brief in. Federall districtt court in New York, in supportof:a motion to compel the: F-11C to producreer-tain documents that RJR belierem , would exonerrte:it.from.liability inn the civil penaltycomplaint: RJR' did not describe the,m,Eurther than m say that "1f thcrc are documents ilt the governmenis: possession, eustody,. or control exculpating Rrynoids or tending to do: so.. fundamental fairness and duee pro- ttss dictate that't the government producee those for purposes of pre- Irial discovery." Tho. I•TC, and the Justice Ik, .. partmcnt, have said' thaat the doc- .umcnts of which, RJR speaks are protected from pratrial discuveryby the attorncy-client privilege. Theorig inal October compla i nts Ineludcd allegations that the sixx companics (RJR. L.irillard.. Philip. Morris,. Amcrican. Tobaccrn. Lig- gctt & Mycrss and Brown &.wilf am-son) omittcdth: health waming in. numerous cigarettaadl•ertisan.ntsappcaring on, suchpromotiunal material as vendingmaeliine pan- 'UOL+ 6, Not 17, SEPTEMBER 17, 1976 r ~ els,rcounter-racksi'shoppingbags'andstore.signs; f;ilcd to disclose th9e healthwarning in the propcr. - ., type style„type size, and.location ~~ in magazine and newspaper adver-~ tisements;~, and'd didi nott disclose~. I I the properw•arning in foreignlhn- -guage cigarette advertising. -- The July allegations specified that the six companies failed in all their billboard and transirt card ad- vertising to disclose the requi[ed warning in an easily readable man- ner;, that three ot the six firms- Brown & Williamson, RJR, and Liggett &;Myers-faiicd.in-all. of Iheir.advertisingtoput theproper amount ofspace:bctw•een the warn- agstatemcntg and the enclusing rule of therectanglc;and: finally. that all sixfitms failed in all of theiradvertising, too pravide srdfi- cient. space betvicen the liness of the warning statement. The complaints were also amended to includeallegarions that RJR violated: its orderr by omitting the requircdlhcalth warn- ing in direct-mail circulars, and that'. American Tobaccoo violated its order by omitting, the warning from all advertisements off a to- bacco product'callcd Fridays. Thc FTC stated it previously • had notificd the cigarette compa- nicsofthcse allegcd violations, and provided them with 225 da,vss to change their advertising;, before amcnding the compl Wnts. Thcsuits scek penalties up to S104000 fur.eaclf advertisement'in violation oE thre orders, and the creation ota trust fund topaydar advertisements that will warn the pubGuc on thee healthharards of smoking. 00009966 s
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0 - , V EWS Btl `IEFV BUSINESS AND EDUCATION Greensboro Daily News 9/13/76' RJR DISCLOSES PAYMENTS TOTAL AT,MOST'$25 MILLION ' WINSTON-S}CLENf (AP) -R.J. R'eyn- olds.Iindustries Inc,,,, in a disclosure which overshadowed an earlier company statement admitting. corporate political .' contributionsand overseas payments,. "--said'Friday it had spread: out nearly $25 million in possibly: illegal foreign and domestic contributions in.recent years. . .Inc.;, about $5.36 milliom in payments '-Reynolds.said.the total included more. ' than 519 millionn in, "iebates" paid'by it _,. . shipping.subsidjary, Sea-LandService, "primarily to lower or middle lcvel ofdi- cials or employes" of foreign govern- ments; and ;190.,000 for domestic - political contributions which are prohibited by federal law. . The far-flung and diversified corpora- - tiom has its reofs in RJ:.. Revnolds. To-baecoCo.,. which is a mainstay ofthe local economy. ' . Rep. Stesen Neal, D-N::C., whosadjs- trict.inciudes the corporation's head- quarterss in 1Vinston-Salern, said Fddav"to the best off my knowledge" he did', not receive anv o8 tha.5190;C00ear- marked forr political contributions byy the company: The Reynolds disclosures were the re- .sult of an.n internal investigation whichh the eorporation.conducted apparently as a result of fcderal.government.preasurel on corporations to disclose possibly ille- gatpaymcnts: Thacorporatioh said it'made itc findings as•ailable to the Securi- tics and P:xchange Commission (SEC)) under the SEC's voluntary disclosure plan: The disclosures did not includethee names ofanyf rccipienus of forcjgn or domestic paymcnts.'1'he.corpor.tliom said it; domestic politlral coutributjonswcre, made "primarflv to conerrssionall andd presidemiat catldtdalcs" bet.weem Jan., 1960 ' and. Jim.,, 197J: .. Neal, who commended Itasno!dss for.. the vuluntary public dixlo:urc: said he. believed "it would be.a matter of public inlerr:3" to know who gut thepolitioal coutrtbutiutu. "I would savy with total certainiv I - wasn,t involved: becausee the first time I was running was in 1974," Neal saitf. " Former Rep. Vl5lrner b: 9fizell., who ' .; represented the 5th district'~ from~ 1958 to :, 1974. said loday.he had pot read the Reynolds findings and could hott com- -' ment on them. blizell is challenging - ' Neal s bid for re-election this year. • {14ize11 saidlhe received politicalcontri- .~ . 6utions from. Reynolds officials,, but had b no.reason tooelieve any involved.corpo+ - rate money: "We've received contributions from individuals of Reynolds andof course those have been recorded andd are.public - record," he saidi . -._ ~ Tobacco International August,20, 1976 Vol. 178, Nb. 17, p. 30 IHazleton Laboratories acquires PrimeLabs, Inc. r VIENNA, va.-DonaldP: Nielsun,. " 1'residcnt of'~.13az!cton Gtbon tories Corp.,.. and\fanmohan S, Rai.. Presidcne ofPrinuLabx, Inc.,, Famtin,_dale, N.J:, today an- nounced the acquisiiion of Pritne• Labs by. Hazlcton- Lalwralurics:.. , PriincLabs is a majnr U.S. importcr anJ dislributor of non-hnman pri- .. .y mares used for sui<ntific rescarch. - and lcsling Programs. Radeton Laboratories Amurka. hlc., a sub- - sidiary of fP.tr!cton Laboratories Corp., hrctds'.non-ltuman primatts al facilities in, Vicnncq, Va. and Ali:., 'rcxns: In announoinng thc ' acquisitiun. Nitl<cn,and'Rai s1u1ttP Ihut "thce tncr,,,edd enrnpanies will. .WCrC ICsCnrclLsclCnll~ls Ihniugh-- oulrho world of a supply af jm- . -portid non-bumann primolcsnow. - - nnd'' a supply of U.S. bred and .. reared primates in the future."'Thc - new company; 1'.Iazlcton/Printe-. p Labs. Iny~., teill'.continuetmdcr Ihe O0oo.99tyO ~/. sunc managem¢nr wilh, hlr.. Rai'i as President. ` Vfll - Fl .. Nr1.. 17. . CFWTFMRFR 17. 1Q7f; . , .. - 954. .
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NEWS BRIEFS . TOBACCO INDUSTRY Greensboro Daily News ~8/26f76, p. C6 LEAF'SMUGGLIPIG OPERATION FOUND BY S. C. OFFICIALS COLUhSBIA, S:F. (AP) - Evidence that tobacco. 'productsare being', smuggledl into South Carolina has ; been uncovered by state investigators,, a state official .- :said!1Yednesday. . -`•Wee don'tt know how great aa proportionl hute we' . know definitely itt has's been going on;' said state Tax Commission Cha'uman' Robert C: Wasson. -- r -'No:charges have.been brought in the continuing in. ' _ _ . vestigation, Wasson said Wedhesday. ti'hen; the probe `Is finished, the agency may level a fine~.against those '- found violating tax regulations. '.. - - The probe for evidence of tobacco.smuggling began earlier this month after revenues from tobacco products inJuly showed a decline.of 13.4 per cent from July of'•f the previous year. . ~ The sharpdrop:contrasted'with'a~r¢port that.ciga- rette consumption:in the state had.risen 8 per'centdur- - ing thepreceding12-manth period. - The investigators discovered a cigac wholesaler who was not paying.the tax, on. a certain brand. of cigars. "That' probably willl bring in about ;Z0;fi00;' Wasson said. Cigars are.not required to carry a'.tax starnp'ske. the one cigarettes carry. If theprebe turns up morevne lazcd cigars, however.the commissiom may decide to put'a stamp.on all tobacco products, 1k'assonsaid. He addedthe'investigdtors have r.otfound a signifi- cant amount of unstampedcigarettes. He said itwast first.susnectedthat.large numbers'.of cigarettes'.smug- gled,from North Carolina were responsible for the reve- nuedrop in July. ° - Tobacco:Reporter August 1976, VVol. 103 No. 8 Six-minute tar predictor A companyy des•dopedd machine which presficvss.the tar contcnr, of'Inl tohacco tlas cut vhe time necesfarym make tsr mcasucments frnm several months too as tlnleas six minurcs Rnm;hly the sixe o1 a sui.cme,, the W. D. ee1f.0: W911funit euats titAen (USS?jn0) to build.: Threraf thrmachines alrcadp ars inuse ihthe UniraJlKinolum w'ith a 1.'xsnh bcing oparataYM, . tbe:Ameriean 4vf rLgsnintlnn inn the United Statci A Willi sp,kssman said dnee mnre nniu are Lring:.concrrucnd'' in Willi seclmic.ddcrcFqvnenrnninfoeJdivery 'in the US' later th is yn r: VOL. 6, NOr 17, .$EPTERBER 17, 1976 Ina normsl test,.agmm of finely ground tobacco'rag`; is purinto a rest tu&.vhich is then placed in a amall furnace on top of the: predictor. Iris then heared to'00°C; the determined temperatureacw•hicHacigareueburns The eesulting products, of com- . bustion.are eollened end'.wriglied, and this can be related to the level of tar yield. The objcct isno enable tar deliveries oftobaeco to, be pre- dicted, avoiding the need tu pro. t'nsit into cigarettes. Tarfrom the combustion gas is eullected in the liltee to thevight of the furnacee on top of the predictor. 'Thegas thcn flows doough ihe three tubes on dte ftnnt where thrmmain- .ing nr isfilscred out. Tliegaugeon the.ldt indicatees~ thefurtsace «mpen• mre. The Wills tarprdictor irel4 bnain- .<hil&of research scienrisr Terry Long (operating the unir in the photogrsph ) vhm headi. the analprical methods de- velopmcnt sectioo at Harrdiffe It arnsefrom,the need m reduce the timeand..cnsr of rar ma•asurements,and to aid twearch. intn new sttains of so6xcco. Long came up,w•irha plan in 1972 and'. workcd im parmersh ip: with de- sign engineers Clifflltcnnmrldxssd nob. Nevcu in producing the first promrype. The design has been patented imrheir names by. Imperial Group. `The predictoe can be used in the cwmrq• of origin to rarq. our spot ehecks om Inf to prnvidr dataa for nunofacmrers aa an aid rn hlmding" Lsmgsaid. The three pred'ictorsin the. UK.are at w'ills. Ifarrcliffe: Plarcr's, Notting- ham, and the:hnperial Tubacco research deparnment in eristol•, Wills ia giving predlctors to the US Departmenrt of Agricullure and the Unieersity nf North Carnlina.Sr. <ause of the wnrt: they do m1 breeding new mhaccu srra,inc Addrd'.is being usld to che University of Kentucky. O 00009965 0 r
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SPECIAL FEAFURE& TOBACCO INDUSTRY FIG. 3:Obweed msl.lun mu.c.and thN hndk4d br. the lunlu mudel IMVnu. /R11 W' We eaponrmW ®det Ifquetbn I+h tar ae.neou.a .frt.fen1....1 e nm- aenron.af 18.5 •C .M a nLnnbumlJlry .f ar pnnn<nsur.nne..I rroeIE.3'L od. nlaun hnmldtry o(9r.pesvet- Thiss error favored"thed exponential equation, since the moisture.conteat. it prediuted typically lagged lhee observed moismme content,, whereas the moistma conient predicted by tfe lamina and midribb models led thce observed moisture contentt in thee early portion of the curves(Fig. 3). A comparison iaf the mass dit;u- sfon caelG¢ients of tAee lamina and midridb during so:ption and'd desorp- tion showed that both componcnts dticd eonsiderablyfaster than they sorbedmoisture. This dBfcrenr< was partially. attributed to avclling of the tobacco during sorptinn and shrinkage duringdesorption. Swelling scquired energy while shrinkage involved a releasc of energy, Since moreenergy is required for a piven moisture content change during sorption than duringg desorption- moisture sorptinn wass re:ard•-d and desorplion was enhanccd.. The superiorltv of the lyminaand midribmodds tuo the esponcn-- till eqnatioain describingthe physics. ' of thee moisture transfcrcan now bee shown. The cxmductivity of morsttvein the ntidtibwas greater thmt thast in the Iamina; yet, dtecharacser- istic lem,th of path Ibr mnisturc movement was thee ndius.of she. mi8- rib as, eompared, wirhtho hal6 tlricknen ol: Ihe lamina. These factors,. mnthincd,, caused moisture content't to change faster in the VOLr 6,- N0, 17, SEPTEMBER 17.1976 ' lamina than imthemidriti. Although the laminaand midFibmodcls showed the effect of bothh conductivity, and patln length, the exponential equa-. tion showed onlv the bulk eticcl of the combination of' Ihe two. There- fore.. Ihe mathematical! . models developed for the laminaand'mid-a ribtlescribe the physics of moisture transfer better than does the erpo, nenlialequalion. The massdilTusion coefficients for thee desorptiomn and sorption data varied direttlqwith tempera-tume and''indirectlkwith, relative. humidity. The exponential k-vahm also varied dircctlv'with tzmpcraturee andd indirectly with relative humiditr: H6wrvcr- the mass diftusiun coeiffl-eientw•as largerin themidrib Ihan imthe lamina, whcreas the rcverse.wase true for the k-value. SUMMARY AND CONCLUSIONS Mathematical models for thedif-fusinn of' moisture intlsc laminn. and midrib of Ihc: curad, burlev tobacco leaf'f were develupcd. The lamina and midhib were geomc:ricall7rcpresented3 hy the intinise thin shect and the finite circular n•linder, re- spectivelp:.. The modds xcre based onn thee vapor diflbsiontqpntlon andexnrcsced tlle atcrapc lamina and midrib moisturc: cuntcis.as a tunc- tion of time in the form ol'.an.cxpo- nentlalsaries. We developedd experimental techniqnes to detcrminee sorption and', desorption nt'the lar.dnaj and midFib e'ithout separalingtlmg leaf components. We liued the lavnina antl'midrib models (equa:ions. 1?) and'.13)) to Ihe surption and decnrp- tiom data.. R'e also=futcd, the espo- ncntial mndcL (cquatiun [ lJl to Ihe experimental dala and used it as a slandard ol'comparisun. The results shonxd that the lamina andd midrib mudc!s were sub,tan- tirzlly' mrnc acavrate. Ihan t.as thc expenenlial mudel in devcrihinr the expcritnentnl snrplion cunes while the cxpnncntiali model was slighdy. mnrc accura wrhan da,ni na and l ntid- rib madclsin deseriliiog tlie ceperi- menLd desnrptinn cunes:. Thea con- chtcinus futmulated during, Ihe study.wrreasfailloar.. I. Thc.lamina aud midrib tntdels (equation [2) and 131) dcsaribe, the e 00009986
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161L1d'FJJ BR9CFS HEALTH Greensboro Daily News 9/9/76 SCIENTISTS LEARNING TO HUNT UNEXPE'CTED' IN CANCER RESEARCH COLD SPRING HARBOR; N.Y. ' : (AP) - 1S'ho'gets cancer?. Why? .<;Wliat kind? Where in the body?' ~ ~ . When? Clues~to just such puzzles' . are being presented at an eight- ;'.day conference on Origins of. : Human Cancer that iss bringing.g specialists from. 13 countries to'.~ the Cold'Spring. Harbor Labora- tory on Long Island. air center far ' ;_ basic research in biology.: '; Scientists"must continue'to ex- `` peet theunexpected. D4acbe in the next week we may well find the unexpeated,"' Sir. Richard Doll of the Lr.iversity ofl0xford, a pronil• nent British cancer researcher, said of;the.search for cancer's causes. ~ W'hat'peopl'e eatmayplay'a largerrole in causing cancer than hass been thought„ said Doll. And thefact'e he said,.caneers comrnon in industrial countries are also common in. developing countries "rnakes it difticultt tobelieve in-dustrial pollution, can' be' responsi- bledor a major part of cancers.""It was once.assumed cancer was an inevitableconsequenee of' aging," he said, but noww it ap-pears "agin;g per se may be itrele- vant"' wilhcancer being a matter- of localL long-term exposure too agcnts capable of causing cancer:. It is.estimale&nowthat 80 to 90.per cent.oflcancers are caused by things in ourenvironrnent„ whichcan includeccrtain frJods.. smok- ing, radiation and chenricals,. Doll said. Ikthe guiltyagents are iden- tified, thev'can be controlled. Viruses are amung'g suspected' causes, he said• and peoplelhem- selresvary widclv'In susceptibility to diseases, inct.udrng cancer. . As a source of neww clues, "we are now bcgiiwingto realize that several'l differentt futorsmay com- bin^" to produce cancers, Dol1: said. VOLr 6, N0''r 1''7,0 SEPTEMBER 17, 1976 _ ., .. _ . -i : Intftisvein,. Dr. J- W'.. Berg oG the University of Iowa said hot'tea,t hot coffee,or alcohoCmay play a role in.cancer of the eso', phagus, although none of them contain any known.caneer-causing chemicals. . What may happen is the hot bq-u~d or the alcohol removes anout-er+layerof cells in.the esophagus, exposingg cells undereath which have nott yet divided to'action by' cigarette smoke, Berg said. Dr. James D. liatson,, director of the laboratory here and.a Nobel Prize winnerfor his role in help-ingg explain mechanisms.of thege-nct.ic code of life, said, the conference would review all types of possible, cancer causes. "We are trying to take the human view-point," not just thosc ofenv!ron- mentalists, virologists'or other specialists, hee said. Watson. and Dr. Howard: H. - Hiatts dean of the Harvard School of PpbGc Health,, organized the conference. C&E News September 6, 1976 Vol. 54, No. 37, p. 10 FDA Is cunsiAerinq a bTn cn tmo fuod color additives. II also is considering. on tha ba3is.o1 a mAimreview, banning use of 10 o0rar co!ors once used in cosm4lics; placing 20 atldllional aCJpbvea on itspermanuntty,np- proved!list; and specity,ccJ.-.•Jdnionol tests needed Iw 52 other u]dilihos eeiorc 1N:rn ianenl Lpproval. l he Iwo food colors Ins a rencY inay't.an arc liye Ficd No. 9'.and cvLnn black Arcoroine lo FDA,.nud No. 4„uscd to color m.vuschino cherr;.esand innCLlcddrLgsd mly'be . ossocintcd vnOJ the forrrolion of ufn:vy bladder pctyps and odran.il Ltroplqy iadons: Carbon b6ack Is of cencern bccausc thcru is nJzc,rq7ate melhe J ol CcleeliiwJ IY.e presencc of low ,.-vclsof polynuclee.r uromaties, ` mnnufaclurin9,r,oc4,ss by-prcducls, and knowmcar- ' einoilens,.in fie subSFna+:. 0
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SPEGIAL FEATURES TOBACCO INDUSTRY 1'tl Gf~itt~ ~`b~kY'F~' 4~!1 Fl l~>.StY4 Unit<d.Sntes. p/ Amerin ie ~ BROCEEDLTIGSAND DEBATES OE TIIEI94a' CONGItESS, SECOND SESSION Reader's Digest Articles Misleading on Tobacco Subsidies ervca:.orIobbyl^ written by Sldney & FIeW.'Dhls subsldyfor the distribution of.Its moge- HON. DAVID N. HENDERSON artlele b not factually correct snd 6, dnqboaks,sndotheritemssent'through lhercfore, mtslending. The vtce Gresldent the mell. - p~A 4f Reader'a IHgest„ C. IL Devihe.. sent In 1975 Federal. State:,and loeal tasn y119'RE 80n86 01 REPaE9gtr[A'RVPB Sgembers of' Congress reprintsof' this an cigarette sales slane amounted tu $5.7 Wedne[deg Jggv :g, 1976 arUele by letter dated JWy 9,.t9]&. billion. Federal taxes recehed were over 1llt.RPEAEERpre.tempon. Under s, AftnrCrutestingtotheeditorsof Read- $2.5 bI111on. The:cfore.. whateve[ small previous order of ttte.Rouse: the gmtle-erl Dtgest3hat their earller arttcles had amountwas apent'by theFederalGovcrn- Lt9n fnm North Carollna fNr. ftenav-aot been factually correct, I dectded'~ec- mcnt that could be related to the gra'r- g9nT.le nai;n/[eII for.5 mlhutes. Uon should be taken tao defesmineand Ing of tobacco.and the promation there- Mn NENDEtiSON. Mr. Speaysr,.theitubllalm thee postal subaidyy thatt the ofLsasm:dllnvescmentlhthecomsnodity ' Reader's Dlgestrecelvm. ]n.the Pastal RMGC['s Dlgeait has done 1Lt again. Om that Reorganiratton Act ol 1970. I..oRered an praluees such highh tas revenues. I tevereloeeaslonsduringmyeverl5yeanamendmentthet'.bccamesectfon363gof wondcrhavthcRhrder'sDtgcstFeECral .of[AtKreselonAlsetytee.theReaderbD4 UUc39,UniRdSlatesCodc.thatre0ui[es tnxrswouldttlslefo.lUpoatWSUbsldy. [etthmcarrkd!severslmtsltwding.adl- tb<publishersotmaqavinestaspanrtaally I surc would ake to be ablefo write eles re6atHln9 FMctxl subsld/Es for NereCUest thae lowcr puftel rale tbat cn- ett unedlfed article for Um Reader's,Db erowNg and sale oftobaccoend to- tlpez the publication tolhc aubsady' I gest suha<nbera tc1'in9 this aory,.but my bseeopradYets.'Ihe July Sssuaof. Head- epeakof. Slnce theirtecttve date of that reGUest In the pst for such au oppor- ethSY.geatcontalnedanothrrstfhartlcle prov6lon,.eheRender's.Dlgeathar,re- tunllyhasbeendechnedbyWeedtturs enlltled'Tlmero Crack thelbbaeco'i eelred ahout'S80,L00,000.In taxpayess ottheRCadmeDisest. 000099'78' vOLt 6, N0''f 17, SEPTEMBER 17, . 1976 956
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NE V V S BRIEFS T©BACCO'INDUSTRY Chemical Engineering 8/30/76, p. 50 The oudook for synthetic tobacco turns cloudier, as two European.contondersin - the smokiiug-matcrial-supplementsstakes.rethink plans, expressing doubt about •eonsumenacceptance. . • ' Counaulds Ltd. (London) discloses that it Itas shelved work on its cellulosic ma. _terial, Tabrclle,. aRer.spending$1.8!million on development. "1'he:company's prin- oipaf hangup, atcorctir.g loo chairman Sir Arthur. Knight, was the $3.6 million'to - $5,4million needed to put Tabrclle through the complex..oest program called for ~ by Britainh Hunter Committee, a.govemmentaancrioned group entrusted with setting guidelines fer evaluatingg thee safetyof cigarettes containing suchsupple• ments (Chms E11g., June 21, pp. 80-84): --- BayerAG(4everkuscny.West.Germany):isalsu.soft-ped'alingeommemialization of its own supplement; tradcnamcdRCN; followingeke end of:an agreement with H.F:.and P. F. Reemtsma(Hamburg), under whicbtheHamburgfirm.would - market cigarettes containing the Baycrdcvtloped material:.Bayer believes that the .: market is not ready for supplements at this time. Buo the company hopes for a bet. ter.climate later, and both it and Courtaulds fistend to:get dack.into the field quickly if market activitypicksup.' . .. Only Britain's 1\SM Iltd. and the U.S:'s Cclnnc.e:Corp:. have builtt comniercial- scale:tobamo-supplhments plants. Another contender, Swi~tzerland's Polystrep AG •hasyet.to~make.a decision'to go commercial. In any.case, approval of supplements in the U.K. is not e:pected:befaro early 1977, the carliesvdate bywhich a backlog of govemmentlegjslation regulating the materialicanibe adopted there. C&E News September 6, 1976' Vol. 54, No. 37, p. 52- Herbal'preparationsmay •- )oll.lhaunsuspecting - It.inald It Su-PeLet tire 11CW1 sch:wl uf Ir:vi.ine I as In:inted uut stronehuronts uf hr rh t onp+rntiunn• xtir.:r uxc hns hern eharply pd.'19m prnlucts mrlude tij'arates. smnkinyInixtures,.tea4 andd ra'asrict They nre s.d.l lspira0;: in hr ah8 N.1 nno Irc mnii. Dr. ~ir,rl rm^a slnres that Iffd distin: t hr rl:~ arc mmmrrcisfly aenilsh!c ss sn,okin¢ snl:.t6nccs and %ao h:•:hs nnd spi,;r. f••rin-hn1 gn. An'.nqr,tFesr hrhus idhr.titied 'ln Iah•.m•tiae sut~l::uces. whirh ir.trprnduced a numlarotea.xuofirnnstcdinr. - 'Pun cases3iit:el ha: srrn n:rned np at tli^hnspit: asarr+ult:+.'cmnt:uqr ?.1int Bidie.'1'hcse um I:nnA.rnllcdd ribarrltea mmlr in Indiu.nnd dlaritaurd uidrfv in Ihiscmmlrr m "n•..nu•Ir.!:currlrctud Gne ludian lirrtrs.•' Rhthnf th•• patien,s xtte. divwiemed mtdl.nlh:ci•,n11nK1 on' nfthtm ",e, IittlP anin:ata aml in.erla in Ihe es.miinatiun n.. m. I1:.: ~ivgrl and' hls n.llem•uesnnalyrrd'smne Stiut lliili. hy par" clmmnnu;;raplw s.rl mu•walnx- tmmclrv.9'hr>.Orn:d uial.•ach nmtnlnetl alwm Iti micnp,r:unn nl a1n,lanenmLi5 miin,,^r:nns ul snqa,Gminr:'1'he.amnet ar.thc.r niknh,itl. f, thr Ilu•rn apyle •u.lim.vm wer•vl 1P:fwa:frn•lw:itun I iil lhe ci;:nrru,a. '1'hr Ot:Gt •wii•uti.:u e•ti-mnted thnt one uf the p.rtiruls h.~d Irt•en . bkingnlwmrdll:n47tnl\ta%mr. 7rer.dey . .J tntal :dln7uele nndthc utherrahunt O.alOrex. v01i.,r f)~ NO't 17, SEPTEMBER 17, 1976 Another patient had lnimed aflrr smokinR nnealareRuma Itidis ci;;nrette. Thnegaspeo,alu,frunt lixlia, are Irbelzd fulmccn nndlwdd'.us Clus A ci;:vettes. Sicnel's prnnp ass:syed'some of Ihc cigu- ret l ea nt 0.4'1 tn 9.01% n irnt i nr, m rn l u red to 0.57 tn 5.0"s ftir.rgad:.r te'.~:reco c:,;a renrs.'1'he'..palienl had. l :i tnirr,mms per millilitt•rnf nia3inr in hinnriue. Dr., Siq;cl'. tell.. simil.u hm rur +,nries inmtl4ing herhul tras uud capuhs. One pnlirnt, n veeMnrian xhu avd'nn almhnl, eiltnretlrF, or fofter. MYUnIJined of Iler- vntnnos, insmm.. ia, nnd "Ininnr Irtm- blinu' I{rwnrdowniuga.l:,nnSl:rnmspcr day uf Ca1u I(nls i in uaP•ni,-d, which he Imd uvt mhcrl i+s•I a. n"Ilr.uu lied:' The slufllmmrd unftn hrcrnun:l kule mrt, aM Ihe Inlicut wn.gctl'ingehmit IpOmg p.•rdayol entlr:m•irorn il.'1'hat nnuunt. I te::ieCrl up's. r,:uhl h:rvr amvenled fur lLc ulnerrcrl'.nynila:.ms.'fhc Patirnlwm . nA.i.rd Inrtnn u in, Ihc ruysul," hutt rt•iusrd on reli;•,i:mx ermmds: A seeond I:nlirnt wa. .utuukrd he mmisterr nfler driukinG mnm,-G tes. 1'der rgmptnma sanld In• hi id In mvri.l irin, m m~mmmiue oxida.e inhBlilur ih nun.irr„ 00009967 e
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SPECIAL FEATVRES'. TOBACCO INDUS'PRXY sensitivity of theload I cells and'. digi- tal recording s,vstem was f7'Lrounts/g. The combined'accuracv of the sjstem wastlevun:.A second chamber was consuuctedfor the desorption experiments.. The opemtion"of the desorption chamber w•ass similar to: that of the sorption thamber,. withthe exeePtion of the ainlow sysrem. We placeda smaller fan in the desorption chamber to, provide continuousair circulation to facilitate moisture transfer m the= salTsolution. The testt plants were always atwcdd in a dryy environmenn (40-45 percent't relative humidity) when they. wrore'm not being tested or prepared for a. tesf, Twenn•-four hours before a testt w-asto begin, four test plantswrre's moved tmtha desorption chamber for crondilimling too a uniform initial'l moisturetommnt att the test tcmpeta-ture. After we placed thee plants inn the sorption chambcr, we took'.k weight readingss at 10-min intervals's during the first hour, at'. f5-min intenals for about 8 hr. and att irregular intervals for the next 4 to 6 hr. We tooka 6nal rcading,about 24 hr aEter the test began.The. tobacco was then transferred from' the surption ehamber'totlle desorp• tion chamber which w'asmaintaihcd's at'the same tempcmture as the sorp- tion chamber... Desorption valuesww-res recordedd at 10.mio intervals thee first hour;, at 15-nlin intenalsthe second hour. and at 10=min imervalr thereatlerr untill weight loss wasws smalll that. longer irregularr intervals were used..'fhe half thickness of. the lamina and the midrib radius were doter- mincd aher completion of the tests. We removed the paraffin and: con- ditinnrd the tohacco at 24 °C„ 75 percent. The half thickness of the TAaCE a. NASf. DIFFVStON [OE#mCIENT IAV ERAGE. OF rOVR.hE[LICATIO\51 ASh FL•NCTIO.Y OF TEN9ERATVAEA.vn REwrIVE ulrolmrrY t.n. nu - °nmlmne•.. Neudumvnn.eautnenl(enantp.5ot1 Temp, • N.Lt Mmnlnv. LmAm a11dn5rwmue aRdNb C I+rtem maptian.oevuon deew,.° dnol911on 13 75 . SA.9 1i65 19.76 . 9509 . te.6 2f r5 TS a:S~A. 9.601 2299 29a6 47.10 a1.20 s2non 211.7 la aa Oaa9 ]sx 13.91 a. 838 tes a. 9a 64 2.oos 1920 An9 25r5 ar.t9 ar.u9 s.aso alarB 13 n . 0.11, aos 10.25 9230 18.5 9a. 1.0112 : 50, aoao awsa. 2e 9r 1.493 IDaa 50:19 1626a nEelv w le°uwu o/ T.51. a. VOL. 6, N0, 17, SEPTEMBER 17, 1976 lamina varied very little, therefore: wr used the average of 0.00305 cm for all plants. We measuredd the mid- rib radius of each leaff at approai. matelg 13cm from the pointt of altachment'l to the stalkk and cal'cu. lated an asrrage radius for each plant. We fitted equations [2] and [3) to Ihesorption and dcsorption data using the mmhnd (Marquardt 1966) of minimizing the sum of squares of the.e differences between observed and predicted values of moisture ratio. ® (t), through an iterative process. The computed parameter was the mass diffusion coefficient that gave the best fit' of equations /2] and (3] to theexpcrlmental data. The mass diffusion coefticient of the lamina and midribb is analogous to thevapnr diffusion. coetfieient of packed flue-cured leaves'deter- mined by Stinson ct al. 1974. RESULTS AND DISCUSSION'. ThemassdiflLsion eGeflicients, Dy computed by fitting equalions [2J and 131 to the snrptiom and de• sorption data areshown in Table 2. The values were averaged over repli- cations(plants): The concsponding standard errorss of estimate for regression, asrraged.d over repli- catiuns, aroshown in Table 3: The corresponding average k- Yaluescomputed in fitting the expo- nenlial equation (equatinn /4]) to the sorptian and dcsorption data are shown in Table 4'. The average standard error for the exponential equation is slsown in Table 5.. A comparisom off the data as shown in Taliles3 and 5,. showed that the malhematicall models derived for the lamina an& midTib were far superior Ib theexponenliaf equa- TANLT. l. AYEAAGE VALVE OF PARA]ICT[R k INEXPONENTIALFIjGATIJN /fVt'AT/0V GI AS A FUNCTION OF TESIrEnATUREAND RELATIVE nV\IIUITY Nnrm vl ondn k-ealue Ihi 1 r. hmo:. _ newn•e aum~dar. L.mm. M,dent 4mma Mtdnb •C Veettnt .°epA.°n meVn°n defamliun. deelntln~° ta. 16 u.oaar u.an. u.xusx 0.13.9 Is:5 75 0,06.7 n.naa as~.e 0.tnot 21' 75 O.I1ir0.Y666 0.6555 0.'21T. ta ee 00259 9 D.mTl 0.1813 0:1ee5 ts~s nd onesa D.u2.c o:1.w o..teux sr ea a.0e91 nn5.a o.esns 0.2310 ta 9s nnzm 0,01,16 01566 e 0.1470 1a.5 ua o.a11o nu:r. o.5ss o.:2+a0 2.1 Or d.04.1. O.U391 0.Of G2 . 0]ii0 •Il.Iee lo r°°inote °I TLLIe a. 00009984 s
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SIP` EE C I A L F E 64T U I RiS TOBACCO INDUSTRY lobaceo to a given cmironment: The objectives of thisstudyxere:. ITnanaytically develop mathe• matical'modds for the moisture com, tent of the cumd tobacco lamina andd midrib during.g sorption and'd de, sorption. 2To'expedmentally. determine lhe applicability of the mathematical modelss to actual sorption and da sorption of cured burlcy leaves. MATHEMA7TCALANALY5I5 Our problem was todevebp mathematical modclss that ddnee the sorption and desorption of the euredd burley kafcaused byasudtlen change In the ambientt eneironment. Young (1964) used dimensionat analysis to developp a mathematical model forthet sorption of~ whole burley leaves..s detached' from the sulk.. Waltonn and Henson (1970) used thethinlayere exponential equation to model sorption of wholee detached feaves.. Neitherr of the models were based onthen geometry of the. Icaf.. The thickness and".shaped of the lamina differ greatly from thnsee of thee mid. rib. Tnerefo:<, cac ean eapeCt the.moistum transfcrr rates of the two mmponents too differ. Thus, mbdelss are needed for both the lamina'and midrib, We developed the problem mathe- maticallqas'a boundary value problemm by applyingg basic mass.trans; fer theory to the geometry to the leaf. Our. firsY.step in this approach was to determine the geometric models'..that best represent the lamina and midrib. Tlm laminaa and. midribl aten the two primary components of the burlry leaf:. The lamina is the thin broad portion off the leaf with a very small thicknessqo•sur(are-arra, ralio.. Thereforc• we chose the infinite thin shect as the geometric modcl'to repre: sentthc lamina.Tbe midrib,. central vein of the 1-.n£ Sasa dijmuter.of about 0.30 to0.+5 cm trcar the stalk, and is tapered toward thee tip. The.crost sctlion,has.n a V-shaped notch in the top„ Etecaune of the vcrv hi&It length tuo diameter ratio of Ihe ntidrib ::.d its neady' circular' rrons sectiom wee chose Ihe.e inlinitely lone circular qlinderr as, Its geometric model. Several as.umptiuns.were made: I We essumcd that the muisture Irxrssferr between stalk and midrib. is nrg!igiHle to permit use of thee inlinitch long circular cvlimrrr as the gemnrsria'tnwel for.lhe midnb; and. Iherchy, to reduce the problem to onee dimension. VOLr 6, flat 17, SEPTEMBER 17, 1976 2 Wce assumed that each eorn-. . ponent is a homapenmuss materlal.. 3 We assumed that the moisturce content of the tobacco:(between 8.and. 32 percent)'is a linear'function of lecf temperature and of vapor coneen- tration in the pore spaces. 4 We assumed that the dilfusionn coefficient is a constant for a given enviFonr•:ental condition. - 5. We assumod that molsture inn the pore.e space of the leall w•as's in _ thevapnr phase: OtAer necesrarv information was s thickness.s and shape..of the lamina :. differ greatly'from rhose..of the mid- ; rib. Therefore, one can expect . the moisture transfer rates of the.two- li eomponents todiffer. 771us. mudcls:are needed fbr'boththe lamina and . t'j midrib- . -. We developed theprublem mathe- ~matieelly as a bocudary value : problem by applying.:basic masstranst . fer theory to the pecmetry to the t leaf. Our first stci'l in ihts approach . was too det.rmine the geometric , models that best represeno'.11m lamina c. and midrib. i Thc lamina and midribb are the I two primary corapoucm> ol: the ourley . leaf, The laminx is thee thin brmd. . portinn nG the.lcaf with a.verysmall .. thickness-!b-surfaee-area ratio. . Thercfore,. wc chose the 'nfinite.thin •sheotasthegcomctricmodel torcpe: . scnttlrc!:mina. Tlm midrib, central vein of the IeaP, has a diametcr of abmn 0.30 to. . 0.45 cm near the stalk, and is tapered : toward the tipi The cross sertionbas. . a V•rhaped notch in the top. })ecauseoftfie vcryy hiqhlength to diamctcr. • ratib of the midrib and its nearlv.eacular cross sec:ion, wee chose the t inGnitely. Inngcircular eflinder as'. - its geometric model, Several assu mptions were made: r I We assumed that the moisturc. • . transfer bchsxr.u stalk and midrib - is uegligible to: permit use of tSe infinitely long circulv.r crbnder asahe ' geometnm.ntodcl for the midrib. and, thereby, to reduce the prolJem to one dimension. i 2 We assumsd that each com- : ponenl is a homopcncous.matcrfal. 1 3We aseumed Ihatt thcd moisture • content of rhe cnbvs.v{bcn.xrn h and • 32 parccnlTis a lincar'tunction ot' leaf • Iennperature and uf vaporr cancen- ' tration in rhe pore spaces. . 4 We assumed that the.dlf)'usicn . ~ ooe0icientis a cnnstant for a given envirunmcnralsonddinn, 1 5 We assumod dtat muismre in .. timpnre space of the Ieat'' wass in I. tlhevaporpnau. Other tlee,s,ty infnrmatibn was 000099,91 959 0
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NEWS BRIEFS BUSINESS'AND EDUCATION Greensboro Daily News 9/11/76 RJR ADMITS MORE QUESTIONABLE PAYMENTS WINSTON-SALEM (AP) = R. J. . Reynolds Industries Inc., North Caroll- na's conglomerate giant, admitted Fri- day it. made nearly 825 mllllon~ In possibly Illegal rebates, payoffs to for- eign governmentofficials and domestic corporate political contributions. In a detalled statement released here; Reynolds said Its previously announced, Investigation by the audit committee de- . temtined that: ' 6 More than $19million "in possibly lllegal rebates had been paid by its ship- ping subsidiary, Sea-LandService Inc.,. to shippers, consignees and forwarding agents during the period 1971 through 1975." - ® Some $5a8 million "In questlona- - b!epayrnents" was made "primarily to lower or middle level officials or em- otoves offoreisn governments - oroffi- ciafs or employes of companles owned orcontroiied by foteign governments - since Jan. 1,.1971J" Of.that, about.55.07 million was made by Internationaitobac-co subsidiaries ofReynoldsand the.ba1- ance by Sea-Land. . • - i OCorporate funds totaling as muchas 3190,6a0 "had been used for domestic polit!cal contributions between January 1968 andJanuary 1973...prdmarllytocon- gressionatand presidential candidates." Federal. law prohibits corporate political.contributions. . , 0 Sea-Land made othei• payments of approximately ;900,0% "in: 11 countries in a variety of situations which,ledto their being characterized as questlona- bie." . i Discussing the 5190.000 in dbme.¢tia corporate politihal contributtons•.the company said, "The funds were gencrat- ed by diverting a royalty payment due, from a foreign licem^eand by paying in-accurate invoices, purportedly from oth-erforelgn countries. ,1 VOL, 6, No. 17, SEPTEMBER 17, 1976 -"The proceeds went into a cash fund," "Reynolds said contributions from the' casb. fundl and legitimate contributions were made through.one or more compa- nyrepresentatives In Washington. D.C:. ' -. U.S Rep. Stephen L. Neal, DN.C:, . whose 5th Distrlct post includes Win- - alon-Salem, praised Reynolds for-the voluntary public disclosure and added:: .."I think itwould beamatter of public Interest to,know who these contrlbutions. were made to...." .As;~ed It he had beem a-recipient of Reynolds contributions, he replied: "No, not as such. Certainly not as to. the best .of my knowledge. I wasa7t nunnlngfor office during that period...I would say with total certainty Iwasn't lavolved be- cause the first-time I was running was in 1974." Neal said two relatives who work for Revnolds gave Individual contributlonsto hhn ofb20oto 000. Reynolds stated titat ccmpany officials had no reason to believe ttie recipicnts knew the contributions were coming, from corporate funds. If any politician did know he w•astak-ing corporatefunds,Neahsaid."thepub-lic ought to know thnt.Ifanyof those politicians are runnieg now, Iw•ouldker• tainly think that would bea campaiGn is-sue; I think it's vrry scdous matter if anyone knowingly aeceptseorporate con• tributions:" In 1?ridny's 10-pageannouncement de- tailiog the ccrporae activtties, the, to- bacco and shippinl;rjantalso tclcascd detailsofthe b1vestie;:tion to the Securl- ties artd Exchange Contmisslun In SSaslt- Ington. Its release omFridLy referred Itsiirst hint of dumestic pohtical contributions in late May and noted "at that time, thrrn of the partlcipants In m:ddngtha conttibuttom re^.igned as officers end.dt- rectors of the conrpany." 000099'72
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: SPECIAL FLE_-,ATUF1",E=& TOU11CC0 INDUSTRX evn,le, but overestimated during the latturr portion, In conuast,.. the exponential modell overestimated moisture content during the initial portion of the desorption cun'e, but anderestimated moittare crontentt d'urmg.thc latter portlnn. Acomnaro- mn or tl:e magnitude of the k-values. . for lamina and midrihb in. Table 4 show: that thee mo151C:C content of rhe: midrib chan,cs.more'slo+iy thanft that ol'tlia lamina. The standard errorss of' th• diG fusion models for Ihmilma and. mid-' t'ibwtre of the same order of nlag.-nitude for both.sorption and desorp-tiuls as.t shown in Table 3. The c:po-' nentiai equation shaaed.a greaudi6ferenee between the standbrd. crrorss forr sorptionn and thosce for desorp- -lion (Table 5)., Tfie..standard~errors'e were much lonxr for desorption, thrn for sorption. 7hee diffcronce was sugreat that'the exponential equation (Table 5) showed lowerr efrors for dcsorptior. than did'thed diffusion modeli (Table 3) for' mintd ofl the nine enviranment,Tl condi- bons. 7hus, for accuracy in the Gtting o[ txperinsental data, the resultsshoutd that the exponential equa, lionn was slightly superior tq the diliusion mwtelss for lamina and mid+ rib desorption.. ' A, compariswn of.f the standarderrnr for.desarplion.in Tables 3.and 5 sL'DUed'.that.the cxponential'.cqua- lion was superior to.the lamina..andmidrib modclt at )lieh.h hulniditv:, whereasttie reverse. v,'as true at lowhumiditri:The rc!ative humiditvwithin Ihe.chamber.increased siif:htly' (aa mximum of 55 percent) upomn introductinn of'the moist tobaec'o..into'o theehamber, andd ltlenn decreased. to 44 perccntt oserr a" bhr period. r, wr.arnrn.erY a ~ WOL/ 6~ NOt 17, SEPTEMBER 17, 1976 HGi. ] OLwrrMmnlMam mnlent .Pd IE.1'PnolICtN'.bT Ilr bmW mnCel lme./icn (311 .nd Ihe e.ymtennJ mOdal lennden (all for uRllap of 1M ruPln...u . Lmlkl.mn .f 19.5 'C md s re6a....6omldlt/..1 9T.ryr- s.r. TAdLT 5'. AVr.RAGp.STA\nAnn e:nnOIt.IY PERer.VTAC[ Or FttIISTUItF. UOVTY.tiT~Uf. E.Y.n vA A.vUlnn1111190n1 L4.lrnuwrroNs.s Asn a-Itl:.recrrvn.vl.sT v:tluuu5 TEM eERATi11tL5 .V:II It EL AT1 V t1 110111 U1T115 CnrilonmenW eonmaom• sund.mevormercent.n,a~tm,eromenn aelai.e- ---- T.mp, bummnr, t+mtn+ SueneL.mm. Sneab ~O. pe.amt wrpuon wrytten drmrvGOn<e..natnn u ss 0.30 0.a5 0.31 0.22 18.5 75 0.32 0.4t o.co 0:1a ac 76 n:aa o.xc. 0.14 0.21 13 u 6.39 0.411 0.39 0.31 l60' ad 0.51 0.91 015 0.49 ]a. a1 D:e9 0.H O.Sx 0.1a n. 9e 0.51 1.01 0.65 u.se sas 93 0.51 0.59 o.el r.ze 53 91 GJO 0.41 ' 0.7. 1.]a •neI.u.e humm,tle..rs mo.e mr'mmt, ar.lr. For d.rarptwn. Ibew.amn rmre.en w, ..~.u•ena,Uon,. nam.ln.n n.a ron.<m m. eero.. u... plae.u m.n. aa.pe.c.nt,.a.n.1 nammuv ae.o.pl.an en.n-mn.n1. lion as matherrtaticai'. Frcdietors of ' burleyy sorption... Tha..uperiorityI ex- tendcd to all cm'irunmcntal cundi- tions for both laml:m.a and rnidrib sorption; the standard.ertur.of euua- tions (21 and 131 w'asahow one-third that o0thc capnncntiull_m,ation. Ewamp!es, ol" the larrnla cntptinn and dcsorption data a:uog'.v.ilh.the prcdiet;on eurvcsr tmr.l t`e lamina and exponential modcts are shoxn in Figs. 2 and 3, re.pcctivcy. Ghe lalnina difTusinn modd gener„Ilv overestimaled moisture content during thee initial poninn of the sorption curve and undcrestimlcd " moisture content durann the latter portion of.thatf cune. lhe exponen- tial. equation typica!!y nnderesli- mated'moisture mntellt during the initial Iwrtion n0 Itle sorimem culne andbad!yd overestim,r.ed, in the extreme latter portion o!' the curve. The lamina tnodcl t)pm:liiy under- estilnaled moislure ccntenNk dnring the.initial' portion of the dcmrpcion 'f TAInl1:5. AL'ERAI.'1: STJ.\UM1I.n 1'ltn/):IIV 1'r.la'E\TAne O!' M019TV Rtl{U V TK\T V V r51'oyl']TL1L 6GIIA'1'ION (f4UAT10N 4) ATY \IUll"i Tl?Ip.^.I.AtUnla A N U IL ECAII V al II Ull l ll l r16 5.. En.INnmrm.l nAlnun,- alantlca frrnr tVnernt ilunaun. euntm,ll Temp. Ie hunadrtr. perer.nt L+min.' aurPllun x1/Arn4. lu.tll.an L.mbv EeWrVnon' H.dllb . defarUtlalt u 15 3.03 0.77 0.211 0.23 u,n Tb 0.eo Lol 0.32 0.32 aa 'la' 0.40 O:a9 O.fe 0.a5 u es 1.35 1..1 02. S o.59 Ia.e an r.sT s.19 0.at a:aa xa e. r.5a I.u a.ss u.aa 13 Oa ]:aV I.fil 0.51 UA9 rLa UM ].4T 200 0 CA1 0,11 Sa 9T a.0a 247 0.30 4.5, •Rrl.r, te bulnule al T.Ide 3. 00009985 ' 963
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NEWS BRIEFS • BUSINESS'.AND EDUCATION Reynoldsaaid, however, the three have "remained as employes but with reduced respan+_lblUUes and cornpensa. Uon." Reynolas did not name the candidates who received the corporate contribu. tions, and said it "has no reason to be- lieve lieve that any recipient knew'that . corporate funds were involved." Goncerning Sea-Land, Revnolds sald It -. hopes Its "full disclosure will help stop a - PracUce that has plagued the shipping -lndastryfor decades." -'s :r- -t)f the $19 million in. possibly Illegal -rebates. In 1971'-1975,.approximately'S11.5 million.."related toAtlanUc business; ap:- t - simately3amilhon related~to Paciflc musihess; and the balance to Caribbean business. The compaay comoared the $19 mi1- llon In possibly illegal rebates to the pos- - sible $3 billion in revenue during the four.year period, saying, "thee total was less than-0.G: per cent.of SeaLand's rev enue in the periol" The company said the rebates and rei lated practices by aa-Land, "ait.ough traditional and pe:vasiveln the fnterr,a, tional ocean shipp!ng Industry, neaethe- less violeied co:apany policy and, may have vialated'tha Shipping Act of. lCitt."' Re.}stolds said SeedSand has made a 'full, voluttiwryy d'sc!osure to the federal• hioritime Ccmmsslon and ' ;t.ls. antid= patcd that an a>..:ee,•ncnt vrlitbe ranched which vrill ihroivethe payment b.rSeaa . ' Land of a su',:-aiUa1 civil penalty and po:sible oth;rsanctlcasl The compnny sn:d that rehates, In part, wetn mza: irom what !t caliVbftk book funds" and tt:at mislabc;i::g of ac, counts was lnvolvedl . . Top manafiementof the parent, Reyn~ olds, was. ige.orant of the rebat!ng until early 1975, the company said Fciday; ' emnt:asL!ng "tL-at sll I:npro?er tebates and.all oif-'ucok funds had.been.lermh nated by Sea-Land." Atterhalt!n; the.rebates In the..Atlan• Uc;.l?cytmids;suidl "t4er.-:.told that re- balin; by certain otherr carriers. cor.titr.rs.tu be pervasiveh: iiataoceuns and! that. Sea-Land bedevcst::at. It.t has lost.business as a resuit. .. Tlie sCAcmrnt Frlday.wasr.,.icased by' Coltn Stokcs. Itevna::s. Iadust: v board . chairman, crd d. 'Paul Elki!t.. presldeat, at..abuur ;:30 p.m! - wea aitc: closing ot t]x tirw York Stock 'rsciizr.Fe. Sticht said the crmocnv's ;r.~ taal in- vestiration uuceeered'the Sea-Land oversenspaymcnthin 1975and.tiegan cor•Cetive nrhnn at th9t'time.t sityfOidS VOL, 6, iti0r.l7, SEPTEhSBER' IJ. 1976 "The company tried to comoete u+.th- out payln+ rebates or enza_;lng in.ot}:er questionable practices which prevailed !n the Industry," Sllcht satd. . "We uederstandlthat SeaLand found that' many shippers expected rebatess and almost evcry Ierclgn and dcn:e3tlhear- rier apparentiy paidithem. SesLar,d'.re- IuctantlyJbined In the.practice alter , tryihS to compete wit.hcut't doing so." Sticht sald Sea-Land "took the lead"' In attempts to put a halt to rebating in the shlp~ing Ihdustry by tryingg toFer- auade ol~ter carrlers to stop the practice- and by cooperating fully with the hiarl• . Ume, .Comnrlsslon.- "Ih mid-1973," he said, "SeaLand unl+ . laterally halted rebating in the Pacific, other ihanrtea,monev' Tca money: Is a smalll pa}?nent to a sh!pping c1Crk; cem- monI In some Asian'countries. - "Whi!e such ir'ivldual payments aree small, they aggregatedi as much as;7?G,09 In one year," he saic'. "That, practice also was halted this year." . In mid-1975, he eaid, the compeny uni- laterally halted all rebating In the Atlan- ue. Reynolds defined rebating as "a form. of price eo,apct:tion. _ond;:cled b}•.'re--'.turning lothe shipper or cons!qpee a part of the posted.d tariff pa}r,.ent.. It Is not.il!egal under the laws', .oflmost'for+ c!gn countries:..." AA company spokesman saidireferences In the statement to. "off-Look funds"' means "shnpiy a fund that doesn't ap• pear In your cempany's books - aoe_sn't appear In.your.bal7nce shcets." More than w5.million iti'.paymcnaof' "qucstioaxb:!! nature" were made bv In• . ternationaitobacWsubsidihries of iieyn-olds, the company sald. hfast ofthis.f amount, the company sL^.ted, was rerorCed as com.m!<_,lont.to cuslomers: on, the camnanv benksbut was paid under cfrcuinstanoes whlchh raise sericux qucstior... It ia not clear,. the ea:apznv said, vrh,thcr L;2 rectpl- enta rrerciIi, customers or indis;dual ofs, ficials oren:ployes.oa the customers. "A6cut. 20 per cont of Ute compaay's foreb~n busir.esais wilh state-owned or cnntrv!Icd cornpanies.orn,tencics which oper::te arcontrol n:onopotics of tobac- co prodll2ts," tlm statement said. Reynolds.s:fld aboutl75:per cent of:the quc4io:rable commirsionshave bcen ter- mipalhd and the rest eill.belf deter- mined to be iltc;al.. ' , 00009973 f
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i NEWS BRIEFS 'BUSINESS AND!EDUCATION The company probee aCtoturne& up some $390,G00 tn.small payments, whkn , the statement said were often made In' `the: form of gratuities tb employes and government agents as a way of obtafNng market informaHon. - - - The.$280,000 in other payments fronr - Sea-Land was made In14 counlries"In a variety of situations which led. o their. bein~ characterized as being questlons- bie,' the company statement said. ".'Ttiese payments.isere not known, to management of the parent.company," the statement said. "Some were small recurring payments lntended~ to per- auade clerks and others to carry out . thelr regular duties expedltiously and falrly, Some wereln the nature of'.graftr ities or'holdlay gifts to employes of ous- tomersi low level officials, poliee and others..." . The company said Investigators of the 8ttemal Revenue Service have been kept . Informed om, the lnternai probe. it also said a federal grand jury !n fVew Jersey Es Investigating rebating im the entireshipping industry. • "'1:he assistant U:S. attorney Ir-volved! has been kept npprised;' the c»mpany sald.' Greensboro Daily News 8/29/76, p., A14! EX-LORILLARD DIRECTOR FILES CLASS ACTION AGE BIAS SUIT t. The forlnerdirector of thequaltity control unit at. ,,. the Lorillardd cigaretteplant in Cr.^ensboro filed suit. , hriday, claiming hee was terminated because of liiss age:. ffichardlA. Wagner filed the suit against the owner of'Ihe plant, Loew's'hheatres.Inc: tie asked thatit be declaredia classs actionn on behalf of all.l older workers who have tieon fired. - ' SyaF.oer said lie was employed byLorillard in:1950 and hadreachel 52 yearsof aec when hee wasdis- charged Ia,t.Jan.. 30. lie allegedhis discharge and that of other oldcr workers was part of a cwmpauypolicy, The policy, he said', is "designed, to replace the company's older svorkers.withyounger worken, and to VOLr 6. NO~t 17, SEPTEMBER 17, 1976 eliminat'e from the defendznt's workforce those em- . ptoyes who occupied a position similar tb plaintiff's in that theycs•ereapproaclung anagc and/or length of ser- "vice: which would.entittc them to full retirementbene- fitsi" Wagner asked the court'to-ordcr the company to7einstate him and pay him back wagess and, bcnefits, plus liquidated damages on the basis the firm hadwil- - tally violated the. Age Discriminadon in Employment. . Act. Healso asked that others in similar circumstances.' . .be.awarded back wages and benefits, liquidated.dam- - ages and reinstatement.,He further asked the court too order the company to eliminate any agee discrimination . by,', employing an affirmative action plam . _, Greensboro Da3;ly News '8/3/76, p'- A15 FORMER LIGGETT MANAGER FILES AGE BIAS SUIT .. The former manager of the product publ'icityde-' partment of the Liggett Groupdnc., formerly Liggelt & Meyers Inc., filed suit Thursday alle;ing he was fired. . '- because of his age. Ted L. Cramer, 52, of Raleigh filed.the suit IhitJ.S. Middle District Court at Green;bnro. He seelsrein.-statemcntto liis former job, plus damages of moretham $211,000., . Cramer allegedihe worked for thatobaeco product curapany from.1973 until his discharge early this y.eac. .-.liesaidhis salary.just before he was fired was $20,OQ0Qer year. He was told. ltesaid,hise discharge was duee to. a~ -' lackof work and a reduction of employes..lie allec;ed lhe cause stated bymar.ngcment was false, and that he , tvas replhced, by a younger empliye. In a L=ttcrr to-the U.S, f5cparhncnt.of Labor notify- Ing It of his intent'.to file thesuit..(:ramer said.thecomr pinv has added four employcs tmder 40 years of age ln the doparhnent wttere: lte worked. . His job, ho said, was filled by a 27-year.old rnanl wha scnrk, imhis former.utfiee.lushis lormer.secretaryand repmls to~ his former sup^rrisor. Such nolic•es lothe Labnr Pcpartment are required .. tinder the Aitc.lliscriminatmn.in lintoloymentAct. Cra• . mert saidthe department diti nott rcachaniagreemcnt with. thi company dutiu; its ineestigation of, his.comr plaint. .. 00009974 - • -
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, Arb'STRACTS CURhShTT CONTLDITS' JOS.IRNAL OF. Ultrastructure '. ;: , Research - .. ,-.•. .•. , A6slncts.in Engyish. '., . ~c,•i; .::~ -. :. VQL,,.55, NO'„ 3' JUNE f 976 : ` J. H: M. WD.uson•v+u M. R.DAVS.v. Fraction 11 Protein Crystals in Chloroplnsts~of Isolated Tobacco~l'r.afProtoplasu: A Thin-Section and Freeze-Etch Morphs~, ., .,,....._.,.•. 303 logical Study............ ......... :-........ .............................. ,j'ournal of - , APPL,I:D P'-IYC,'?QLDGY , AbsGacts in Englsh . . . . VOL. 41 N'A. S JULY t976 -•- ,. &a and age diCenences in Pulmunarymechunim.in nar-nxl noncmoking avLjmta. ~- • ~ 0. J. GiLmn, V. C. Priue. C. O'Ca:n,.~~d R. Q~axJlam 20 TOi:[~J1QrVCIhCf &ptred Pharmucolo oy_ ' - ' Abstracts in EnF,listl_ ' _ . . - . • . .,,. VO'L'.''3.], ~lO." t; ,. ..,JULY 1976 Srevsrr D..Coanrr. eev AteuorcElurnt. Clmlincvtmse and~C:rM.yleatqase InhibitiohUy " Dichlorroe and Inrencnunt,wnh hfal.ibi,mand lnorlhotull'I PAtaphme....:.....:c.:. 74 00010016 VOL. 6, No, 17, SEPTEt•1IIER' 1T, 1976 a
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ABSTRACTS REPRINTS IN LIBRARY 7ti-3'8 Ishiguro,. S. Sato', S. Sugawara, S. Kaburaki, Y. Agricultural and Biological Chemistry 1976, 4'0, 977-982. 722r Brown? H,. B,. . .Neuropsycholog,ia, 1968, 6, 381-388 7230 Je1us, B. L. . Munson, B. Biomedical Mass Spectrometry 1974, 1, 96-102 W'!;'d 0 Leffingwell, J. C. Young, H. J. Bernasek, E. R. J.. Reynolds Tobacco Co. 1978, 1-65 UOL. 6, N0, 17, SEPT[MBER'.17, 1976 , COMPARISON OF PHENOLS IN • SMOKES OF LAMINA AND MIDRIB' OF FLUE-CURED TOBACCO . S, ~. . SOME CHARACTERISTIC EEG .bIiFFERENCES BETWEEN HEAVY SMOKER,A:;D NON-SMOKER SUBJECTS REAGENT GASES FOR G. C. - M. S..ANALYSES TOBACCO FLAVORING FOR SMOKING PRODUCTS 00010019 a
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REPRIIITS IN LITP.ARY • rvN,., r, . c • ., .,. Gupta, S. K. PRODUCTIO.T OF MIRROR AND Prasad, S. N. SILVliRING ON CLASS PART II- SILVERING METHODS' Calcutta. Central Glass and Ceramic Research institute Bulletin 1967, 14, 18-22 , ?0 ~P Hchlin, P.' Hyde,. P. J. W. Scanning Electrol Microscopy IIT Research Institute 1972',.Part I, J:37-146 Chc%na,,, S. X. THE RATIONALE AND MODE OF APPLICATION OF TIIIN,FILMS TO NON-CONDUCTI[:G MATERIALS DUVATRIENEDIOL, ALKANES, AND FATTY ACIDS IN CUTICULAR. WAX OP TOBACCO LEAVIES OF VARIOUS P4iYSIOLOGICe1L MATURITY I Phytoctiemistry 1976, 15, 961-963. 00010020 VOL. 6, NOn 17, SEPl!E[;BER 17, 1976 . 993
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SPECIAL FEATlJRES! TOBACCO INDUSTRY eontrollcd consumer trials to amca.sueh <liaraaersucsas Basmur accepl-abibtY. The third alage, now virtually <pm-. pleted, incolves..the mm1 rigomusteslss or all. Smdies. at Ihislevel rall'l into three calegorirse carcinogenicitylrials, which include the classK.mouseskin- painting lest: reproduction and ttrato- logkal slndies; designed lu assess.possible sfde-effecrs of.smoking supple- mants; and. hnally, lifo-lungg inhalation studies on rats and other ssxcies; which -in Britain has alreadp.led to Ihe.wn- Imversyover the use: of baboons andbeaglsx In a world conteat the Hunterr guidelines are unique,, and most interest<dleorpomlions outside Brilain hope thal once their UK competitors. have borne tha.e expensre of breaking . new ground.. Huntee Committee" afm proval can be used.:to.ward oQfumre esiticism of supplements on reslxclivc domestic fronts. TAe... CT3 million eostt for thee tests carry. mtall developmentt eosls forr the tobacco eompaniess in Britain 1baround f10milliun each over the past five or six yearx When.. the committee I-¢ances the supplements, marketing will.begin. For historical ta.xx reasons theyy are still' grouped with additives in the Finance. Act, but new levislation to bring them.m under the. %fedicine Act is.espearcd too be Ihrouth padiamcnt within the firstt couple of monshs or ncxt )xar. Without hitches. eicarettes conlaining.up to 25 m'. supplemenLcould thus.he on.the British; market..byt lfarch 1977, fiS\f. Ltd alrtadyy has aa large pro-n duction plant'.ready.at..Ardcer in Sdof- land, a IId' million investment.t by Imperial Tohacco... Beporlss indicate. that Courraulds.could''.fias'e'Tabmlle inn commercial production whhin a)ear of the Hunter green light for an additionalimestment off flo-'-0 million.. Andd from across IIIC.Anantic,.Cesanese.ean.. hee e.pecled to provide all the CVlrcl netdcd in tl¢early stages or UK' markelina Similar products.such as.:the Aneb-Amcriean. Batfhke and Bayet's- still mvstcr'mus hlcn& can atsobe ex, pncted to.o cmerge rab;dlvv once rheyhare paned dhnwah ISe Hunter lests- Failure 10 .vln licences a1 Ihee first.atlempt.wnuld mcan a major setback, h'mlhe.searcF. for astfcr.cigaretle..willeertainly nor he ahandamed; even thnuph~ sapplcmnslt are hy, no means unn<rsalle accepi<d ac the movlc0ee- tive wayy to rcJUcac die smoking risk. Impiu.'<m<nlc tu exiNingftlterL, parti- eu6rly tbrouy.h rent0adbn, mforr another Iwssihibty, af dnes an iner<attd of cigurerrc.pap<rs.. Thcxamh mcanwhile cominnea" for Ihat dnsive premiuns hsuws of tuNacco nhich gives ruanimum Nssible Iacte eith nsininmm fnssiblctat. 0 VOL. 6, Nol 17, SEPTEMBER 17, 1976 Transactions of the ASAE July - August 1976 Vol. 19, No. 4, p. 796 MOISTURE DIFFUSION'IN THE CURED BURLEY TOBACCO LEAF Walton, L.. R. et al INTRODUCTION THE processing, tiandling, and stotagee of biological materials usually involve the basic problem of controlling thr.exchange of moisture between the materJall and its ambient environment. When the vapor pres- sure..of the moisture within a material and.the vapor pressure ofthe sur- tounding air are.a unequal„ moisture difiuses imthe..direetion of the lower vapor pressure. Thus, thee moisture exchange may be Othcr adrving,or wetting process or a.a combination of alternate drying and w•etting. Historicaiiy, agricultural'~ ~ crops have:beeo dried.to prevent spoilage (Hall1957; Henderson and P<rry 1955, YYoung and Whitaker 1971). However, manry problemsdo arise aften drying, especially in such hygroeropie materials :s, tobacco, wheat., and cotton. (Young 1A64, Young and Nelson 1967, Henry 1939). Physical properties such.as elastic.. tssoduli are generally funrsionss off . moisture content (Artho 1955)) and', sr.ust often bee closely bontrolle& . during processing. both on and off: the farm. Specific moisture levelss are oRemrequired for a given phase of processing., and;, thus, require knowledge:of wetting.as well as drying phenomena. Moisture relationships in cured' burlcy tobacco ace important since different moisture rtvels are requited r. for.. handling, storage, and manu- facturing. Tn be.hannlcd, the lobaccoo musi.be in order. i.c.. ils.moistures levrlmustl he high enough Ihat itt wilf be soft and pliable. Tubaccoo readily ahsarbs mnisturc from Ihee atmnsphcrn. and tubacco.proauccrs'o depend upuu ustural moisturc Itvclss in the air to order the lubacco onn thee fxrm. Contruf of Burle)'luaf'c otderingg w'nold bee aa natural eaten, siun of flic trend toward mure en- vironmcntal controll in curing fa, cilitics. TI¢ niechani,slion ulf strip. ping andd gmding will pruhablyy re- quire more slringcnt control of nmislure'enn!ent. Butore we can eon• Irnikhe envunnmeueto pebv!ae a spe- eifle mntsluru Icrcl in cured ieavcs, we :nust know.thew respunsc of the f 00009980
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ABSTRACTS CUBd2ENT CONTENTS Environmental It'esParch ~ Abstracts inJinsiish ' - . VOL. 11 NO. 3 J'UNE.1976 L..H. HwWxIns•,P: V. Cucr.• entt L R. W. HARais.. Smoking Habilsand Blood: Carbon Monuxide Levelx... ••• • 310 " .' '_ '' '- AGRICULTU!:AL AND . , .•. B60LOGICAL CHEi:11STR'Y :. ArOclcrand'AbsttactsinEnglish . : !r z •• VOL. 40 NO.i' 7 • ." JULY 1.976 Oefumd MWium ror Crosm Gall Cellsof Tobaccoo in Smpcnsion Culture. •- -~..• .:..:.:::.......::........,•....:..T• Marseswra• K.,6auuism and M. Nmuun,.:.IllS Journaf of Chronic Diseeases • - -Atistracts in English . • VOL. 29 p70. - 7.. 'JULY 1976 A'A ps}•choloeiavland'l behaviourat tom0arison of ex•amokerr.and smokers bv linda L. Prrkr.wn ondNeeiHeH.Cejior ••471 00010017 VOL. 6, No, Fir SEPTEMBER 1'i7., 1976
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ABSTRACTS REPRINTS IN LIBRARY 723 5 Howe, J. R. Laboratory Practice 1975, 24, 457-467 ;'1*23 8 . . . Hsieh, Shni~-Tien Kraft, P. L. Archer, M. C. Tannenbaum,S. R. Mutation Research 1976, 35, 23-2'8 723 7 Irvine, W.. J. S'axby, M. J. Phytochemistry 1969, 8, 473-476 VOL. 6, M0, 17, $EPTCt4BER 17, 1976 A METHOD. OF RECOGNISING CARCINOGENS;IN THE LABORATORY REACTION,OF NITROSAMINES IN TIIE UDENFRIEND SYSTEM: PRINCIPAL PRODUCTS AND BIOLOGICAL ACTIVITY ~ L STEAM VOLATILE AMINES OF LATAhIA TOBACCO LEAF 00010021 99'9 s
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, VEWS B$ rIEFdr/ HEALTH C&E News August 30, 1976 Vol. 54, No., 36, pe 5 Sellnium again an: neegpra to tee alm oyweheyerovem. - pupul (CSEN. Julft2, page J1enmNV "Selen: IpR" I agreo winllhe IxonlnbH Wt xkniumIN3 CeUn aCeepled ae an eSSMllaleYlriilnt bIWVeral aniaVlls owing to As insvlvemllm in. p4tdthiOM.metWnlem. Selenilim.ee woll Ms aavCal otnMaMimsi9anN hn pasNive vellro in peyyirg a al1e.'dtingNmlor.lolmalron.InaN9+ YM: an Nvers6 CMrekllinn tle!wnmi selenNm attvreKa'aM Isalbn ranccr rlvtalny'lus' 'leen oLSOrveO. &bniYm bioeJ Wvels are sip niicseh bwer an tancor patients than in pa.; ren4wihoYepnce/. .... ... '. . . kbwoms./mnetagree wM M illlerpalahm ~of tlfee eeperarerts by Luosey arq Vempupxl. ~ rldl pelMwm ie e&enlqgelYC. They NNe GIeEYree.papera N slopen ol'tlwV'r:er. Several Crganiralipns as wM asiqivNualsNva ci1Foay.eexmiree Ihe Ilree e.pennlema erq 1eua1. riem w bo.puee5nlsde in eeparimenmteesan. Fnt of all Tatleskas.M sl: 16ytd. E. K. Sp: Hbl IdeA:. $3, 16/19611 ard Acra Mr: Cmlcer, 19„ 632 (1963)( used m:conbcls. Tlurcekre; thelr rclwnl slwuu na be senously' eemixrco.. SChaeOCr altl h9leMrr'e ecpernleN (i /a.w.:.. 101, 031 (197111 wascarpLWleEbya.pneurnonia elnaemie where mllwsl5a%.M hisran bm. ThzY wakers eemeaM as.neo that me , 20 of 73 conbol alllmslstllal had Il."Irs'127.~ %I ware nd sipyli licamly G 6crenl Ran tle . seknNa greup Oav to 51) er 6"S. Tne aunvs'. alsu c1aIIIqC.a synilican4 ktrcase in Ine sele- nsleieE ratr.(3p-]5) or.e0%. b rcaliy. Ilq, oppp:ilc sitcaHen is Irw. Tlarv:gcrlasie u'. .ynHieamN.lpwnln mesrlenne qaup conr.. paten b Ne een V aK No slMisl ica l si9niNCBnca ean oe Iur.N Isetween ple ulers.ro youy snCds/ Cenhols. Aho-tlre 9N8 day611eeE by SU%os ale sNenNa-faE /ats k cansieece0.rwivabnl ' f0 ebYN 82 Mnan years whereas 59 % bl lhe .. 1:6M:ols CiN.at 863:Ilays ar equnalem lo 72 humal ttars. M man aN anirrates eanene tnelCerue arqd morlalily goes up markedly wnh ago. lhe Im elaesn in Iu. igmeeR el nW se/ena19 QeVp:. eren Indpn nd siMaieam. mr,M Da espbinM'. Ey.pic's Increaseo age. Nelson et al (Cancee Rw.,:3.320 1191]I( lell.nb 5. 7, an0 Ip ppm . setsniwn hs erganic colntiinaliens n cun ell0 •Mat ard'n a mi:aE klor4 ie sek'rti0e: 1!1 rzts Cul o153slrvivors hnd Iow-9rane hcpalic CeY GXCnpRI, K1AI pnlltlbg1+15 29: W C113e: Ne119Gn al al. memAn NeEil/iGYM1y In O~.a4pYis1!Ny Ua- IweenhYRTOlasia:uM early lulv. Chonec brk hepalilu cnub Yl;acompbl'w:e Msnillhemia- lian. One goup of mis an Nrlsan'e eepernnele wasJeA.a mislnro o/ anmqmun polassiun. wWIMe an0 ammoniurn palnssxsrl selonrro bet Ilcammoniunpe:lSSi1a115U:/w4lwaelenalena. M Iltlnnipn: Nelson i 9rain. il alkwal.lo.mollli cauN n'IVO canlauctl a1b10an, whirA 5! polarll tliror.carcnw9wl: WOL1 6, Nol 1i ~ SEPTEMBER 17, 1976 TKe anlleareinopeenk value of sekNUm b becorning well Ys1aGGsheG. The E4toxltiralion ol Ieary.metals by ecknaum may be+ltpertant F ON2r flWnirl diseases sYeh as h/perlenslOll (CBEN. ksay.3: Cage 2lI. Wlletner a not sele- /11 W II if a LarcillegenlC has net DeM poven ill an Inequlvoeal msFlner. YfellEasi9no0 erper. nlenlscould be dana lo prove carcirqgenicny. On the olher haM, il an animal sheuNl neveklp . ebw9m~ebenxaltm0euqseverely.pdsonBG fu two years by 51010 ppln 0 selenium, w/ul sipnilisance noes tbis esppimem luve la In. m3n3TCerteinly,toafesymlatomswoYlEUeaF mGat'wrvncrsietery Mlscrve0.in Manans.bq pesoreanylur^alormation., RaynnnE J. ^ vnlwllwr. VhD. !?sparlmenfol(liacnemisvy. CG!veWdCGMC, C/eveGrN. . American Zndustrial Hygiene Association Journal. August 1976, Vol. 37 No. 8'.,-p. A-B chlorororm a carcinogen ... nEW's Nalinnal Oancce lnatitum repons' Ihas <hlorolnrm has been found tu cxuse lirer andkiJney ean¢en In lest aninuls. The most (requem findinp wae livcr c::nceq . whioh kiIIN mu.i m:.k nnrl Irnnk mice ivenIhe cumpound urallk IIiFh inciJences or kiJneytumnn- prNuminm0ly onccrour, occnrrcJ in male rnls ar bomh hiFll enJllow dosagys of, chlcrofumland infe- mule rntr at hichdoaaSee.Tlyroid tumon apprarcJ~ in solna fema!e ralc. USP praJO, chluouform wm testeJ, usinF Oshornc-\lendcl rats enJ II6C7FI mlrc Uuw cMoro-' ferm usctl io I/m k.1.ti. ixAOr menn- facturinC flunrucarhnns for rcfri6- tfanli~ irrYW1 pTIV'llalltVan\I PIA1- 11~. It Is: al{o Y,eJ in [atraeAing and Imrifyinp xnliHIotics,>I anin- Iluslriul solccnt. in phnlnprapMic pracminr, aod in.lhaviak Jqulexm ine.:in ,/yes, Ilnl;. and f`s'NiciJes, aS w'rIl alIrl Ellllle IWlll"IN, eouFh mmlicinn; linimenlsanJ sahxv It once eat wiJdy uwdaa an annlhnic. Asra,re.ull:ul this re- prnl. NI0511 hne i. Yal nn alert. It is alinuaee tlw,t .1n.lltq pennns are cs~ eJ oeeun+tiYnaUy lo ehlnn,fann. Iire currcnt OSIIA eeltinp slau:ILld.fiu cbinrufuml in worlplxcee u i.:30 ppm. to ppm has been reemmmcn.kA.. c s
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~io ~ ~ I ua REPRINTS IN,LIBRnRY' Lifshin, E. PRESENT TRENDS IN X-RAY Ciccarelli,.M. F. ANALYSIS WITH THE SEM Scanning Electron Microscopy ITT'Research Institute 1973,'Part I, 89-96 F~reE ~ ,.w- Novotny. M,. Lee., M.-L. Low, C. E. Maskarinec, M., P. Steroids 1976, 27, 665-673 ti C1.'a. N Linsmaier, E. M. Syoog„ F. Physiologia Plantarum 1965'„ 18, 100-127 HIGH-RESOLUTION GAS CHROMATOGRAPHY/MASS SPECTROMETRIC ANALYSIS OF• TOBACCO AND MARIJUANA STEROLS ORGANIC GROS9TH FACTOR REQUIREMENTS OF TOBACCO TISSUE CUiLTURES 00010022 VoL, 6, No, 1'7, SEPTEMBER 17, 1976 1000
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SPECIAL FEATURES TOBACCO INDUSTRY Nature September 2, 1976' Vol. 263, p. 2 Off the tobacco road -' UK cigarette manufacturers have reached a crucial stage',i!n the development of substitute to6acco:,Af[aliT)?iper iepoHs- ClMgetrEs.s containing what have become known as "supplementsl"couW" be on the UK market within 6 1a.4months,. RiGmoasc hcalth Irials, recorn-mended by tltc UK Independent Scien- /ific Committee on Smokingg and ffealth: shouW',hc.completed soon, and' ' three major tobacco companics" with British intcrests-Carrcms.. Rothmans,. Gallahcrs and' Imperial 'roWceo-are then upccted tosubmit'.their resulls~tofhe committee, ' ThetommiRee i: an advisory'tiod)•y to. the Ueparunent of Health and Social $ecurily (DI ISS) ycl'.up.in 197) under the chaimunship ofqhe Vice-Chancellor of'.. Oiimingham Univcrsity,. IJr R. A Hunten If it is sulixfird that the find- ir.gs meet Ihe. Suidtoliness it't laiidown tast year: the committee is.eepee[cd lo recommend the licensing of supple- ments.. for immediate comnsercial development in aritain. Onc.companr won'1 be on theearl)i bandn:agon. Cuorlaulds decided Iast month to hulJ hackan ilsdevelopmenl' ofa lobaccosubslitule.The decisinn: how'ever; wav merely the commercial jidgmemof a eonspan5 lemporarilyy sidatcpping aniarca of heavy pioneerning ezpendiwre which is airesdyy covered hy the others in the ficlJ. Once supplcmentss hare.e been hroadlyy sanelioned, of course, CourmulJai ean jump straight hack intoo the.. arena,. reausnalll¢ certain that the U nsillian- w•hich itt naW s. lu carry, its own prMWcl. Tahrrlle,.Ihrongh the Hunmr teas, is unlikch` la dicirpcarJnan the drain. The cnml•any nii) hea up.lmp two yearss behind tluxc aIreaalvYhroneh Ihe trials. Ilut it ran take this. ctmrse tiecmise ' Tahrcllr is essanti:illy similar tn the. - other products heing tesleW Fy, the tobacco eompsnies. Two I)ys•a There arc, in fact, onlR Iwoo hasiec typcs nf srmptumentl One'.is madt up of Iarg.IS`iwvganii niatrri.lsealled inerl' dilucnts, the nlhcr is based on organiec eeilvlumderib.sliees. Buthnre: an crganic hindCr. On' airrenf ineddinl re$oning-lhal'. Ihee cie]rctte cancer . risk. stems direetly frnm, the tarr cnn- Ictn or sninkc-Iwth kinds of stmpla mcnl pmvidea wfcr alttrn.uivc to.o oNinary tnh.tcco.. Ore.miralls hase.fd s'aricNo...v¢li.as'rxhrrlle and the un- fmaginatievly namN \'S\I ('nev Smoking, hlaterial') give kss'. Ihan VOLr 6, N0/ 17, $EPTEFIBER.17,, 1976 la - of the amount of lar prmiuced byy ordinaryy tobacco. With Cytrel, the main inorganic s'aricq', even that reduction can.n be improved twn-fnld. This «lative advantage is reinforced further beeause..theorganic NS61 pro- duces more carbon monoxide;. a]Jes h.vdes and so.ealled furam derhatlves than tohaeeo, perhaps posing an addi+ lional. though as yet. undetermined, health tArcat. In the event, none: of.f the major tobacco eompaniess in Britain hass plumped' squarely for one type ofsnpplemcnt ratthtr than Ihe other. Gallahers is maintaining an equal inmre+l in hnlh Cytrdand NS\l. Andd while Carreras Rothman and Inrperial Tohacco have movedmore pn.itively in onee partii-nlarr directinn, respectively ' fssnuring CytrelanJ NS1L both com- pmies hare kept Ihcir eyes on.l the allernative..option. These prefnrances have resulted in close resurch link. hmsviceo the retail- ins mbacca cumpanics and Ihe mana- facluringch:mical corhxationc Carrcrzv R~otliman have an arrunee- menl wilh Cellnca<, the US.S makers of. Cvtrcl. while thee lie Hr.twreni Irnprri:d Tobacco and ICI hasaed mthe forma- Iion of shc ioinl cnnsnrtiumNS\fl.ld,. planned as an. reenrual commniercial manufxturer and eupp!ier. In Ger- manq; the dwnical gisnt naycn has'iust termin:Jed'. a Iiaisoo withR•emqmn.h follouine rhe speclacular failure thcre Inst rmrof twu hmnd[•% containing vupplcments.. hs.k for co- operation hetnrn the compaeics and the Ii'untor Cnrnmioco.. this is eoonli-na1eJ hv thr Tnbaceo Advisorv Cmmcil and lus znnorcmb, been eReetiv4 in sn'te.of miicivinev witbin Iheinduslrc nkmt the{'ommiVteels stronS an.lpmic make-up. Threr slaees The Ilnntrr euiJdines. <cnvatc tras inm thrrr xl~ers, with an interim eh-ck :u tlie rnd nf Stoae I. TLI:frat sL.vr: nlrradv nas.ed s~felr, inCtndeJ nrrhuncive eudics of smnke chem- isuv:v o.r,qher ailh iiihalatilm t<as nelnn.., rat\nntl nlnnke\'S n\ef a nrrind nf at Iraa'sis w<cls. Stls¢c Ifin.t~I.rJ shorNtron cln'icIl stmG« uf rc.ni~.uurv trrir:uion in~hurn;m snluntrcrs. At this •rnQC Ihr tnhVrn rnrmt.ni,•..WCrTaleo free under nseguidelihcs IoconJuct 00009979 957 f
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SPECmAL, FE ATFURIES TOL'ACCO INDUSTRY naturee of the moisture transfer prncess better than does the cxpo- ncntial model, (cquatioa Ial) inthatn they include bothh moisture'e eon- ductisity and' physical dimensions of thee leaf, whereas the exponential equatiun shows only Ihecombinede clTe<t of tiic two. 28oth thala,nina and.lhemid- ribdryd mnch.fasterh than they wrb moisture. ' 3I The diffusion coefficients of the midrib are greater than are the corresponding diffusion coefficisnu ofthelamina.. ' 4 The massdiRusion coefticien6. 'of bothlamina_h and midrib varfdirectlyy with tempcratnre a.id! . in- dir<ctlywith relative humidity. Refersntn I ArNn, A..11 1955. PI'tacal Prnpenur of rnred tolramo learn. YienelaEnrNrift 10057-11E. 2Crank. 1:.1961. The mathemalia d aiHaaime. 2amm.- Orfem Uni.reeib Ik.r. . 3 Hall; C. W. 1957.. Drying fvm rrups. Aa^•ultural Consullicg Aasnvlesr Inc. Hr.wldsburg, OHI.. 4 Henderrnn- S. hi and. R: L. Perry. I955. AFricvhural pruren rnain¢dng. 1oEn Wde.and Sms, tnm., Ne. Yort. 5Hcm, P.S:H. 19.19. DiRuriam ie abseuhingmrdu: 1'rnrredln;s of the Nqal Snricn. ScriesA: P1:216di1. 6Marquarde, D. W- 1966... fxan squ.rn erumae af nonlinear parame:en. Ecamsnng DcVaument. E. 1. DuPont Ot~cmeunand.Campan.; Inc, Wilmingrun, DE. 7 Stinron. 2. B.. /l It. Yovng and.T. n:. N'hluter. 1911. F.valilnrlon nP We r.nx. E9tmnm fnr mrrd tn0accn. Peper. t1a: )f:V''J4 prrsrnlyd ar rhe :.aual mretugd,ar AsAE: sml&,lrr, oh. a Wahun, L. It. 1974, \loisture ffdfusions in tle eurcdihurlny tubacrv kar. Unpuhliahed~ Disunchmi, UamnirydTrnnssee, Knor-rllle: TN. 112 p. q V:almn, L- R. and. W. II. flnuon. Ir., 19'J. Mmsn:re rwprivn. M burln «batta:. T[A\.ACpO.':5 dthcASAE9Ji9c6.14t1. 10 1'oanR. 1: It. 1964. Ue.dupmcntt of' a rrlaiunshlp hcnecn rnasturc eontent' and timn In bur4i tnb>.ro in aa ronnolleA. em;r.Imem. unpnldisnm us. rlirrir: Cni n:rcdAn~mray, Le.i~ylnn, KY. I Ir lbmlq. 1. II., :nd F.. L Nehan.. -loe), lnenm eL nrstercvt hctann mrpi:m •undAc•crpimn i nrM1rrms in hwtncical m. trr:as.'fHAnSACTIOyE dths ASrE I0iDbO. 26J. 17 Ynuna. /.. 11. aod G. L. :hlinn. 1•Inl; C..earrh nl hy>ICresis bewrtro snrnoun and drxnpiion iwthcrnuof .hn,. TRANS. aCilDSgul rbe ASAIi IDf iibMl• li'YnunR. 1. /1. acd t. H. 1sTitaka. 19'L.Il.alualinn d ILe Nn'ml6n Nualinn for dermbina lbimbY.'r dnrvbx of peanun in tEe Sull. 71tAN5AC1'tOKS dUe ASAE INl/:ID9-J13. VoL, 6, Nor 17, SEPTEMBER 17, 1976 TECHNOLOGY Chemical Engineering 8/30/76, P..115 HOW AN IDEA GETS TURNED INTO A PATENT Portaany cnCinccrs and'scicutists, fontual rccognitilsll is.ahuusl impcr:nivC fur rsrrcr adcancensent.One scav of reccii'iul- cuch recognition is'lodircclnp:ul idea inlu an invention and qct.il patcutcdl -- C7ry'ton. Dbenfond, 1'ntnx Cauu/f.mf Q Thc iisuunrc of a patcnt rrprxsctns(rrtnril nrapni- lion of Ihrc cnginmrlorscicnliu's tnJmknl a6ili,. Octling a.p:LLCnrcan hr a 11ncd., yru.o~s, fidl of Iwad winds, tltat.donandirunsidurahle Ixncvrr:u~ e. In lLeop'., an rnyincrr cao IilcJiis u..n applion.lian fora pa,rnG farnh•ainiue'a lu' d pan:ni. huvvarrr, thr: scrxiccs of'a patrnF attmn.v arr ahnust mautlnt.nrv. Patcnt I:uriv coniplra.and du'rc:uc wunl:v.hilc h.uk., fornanyunc schan.i.h.x:t di+rniliJ diwnsiun uf in.cn- lire.tedm iqucs and p:uenl pnnraurc. i 7:.;, JI. An inrentinn start.scilhan idcct Thc idla uray.lw tho linal!,csuh of nirmaCCprl><,.rstts tharcucnd,..vcr s IunG tiinr ur iim:tvIwrc curnc quito sudflenlv.° Cn(ortuvald•. this i•aa far a, samc idras eVrr eet Ixrauvt Ihrr ne~n' ur nrord,xll Idras.m'c aqt to Ix IlrelinG, aml eu s{tuuld hc vrriurn dm. n.ts suuev.us possihlc. Ciiqiua'~s wliu vmlk in L burntorirs I.nov. dms dic lal4ur.uum m~clwukis c..cnti:d ryuipmeut..An cxprrimc.nl wu'rc~nlyd isan vspirinu iu losl. So lhe liisf s,cp li.r enrunc •rhn cnlurs. I4is ideas should Irr lokcop.a nutcbuuAin ublch,idcus r.rn Ix..rc- <nrdrd, datrd aud v.imes.cdL'1Lia budwn pcnplc whu fddru thrir idCas alc tuu lial"ml+tl.rn'• un eccm ri- diculuux, Ill bc.witno..rd. Su.h tn atdtnJr iss.um.:sr- nntrd The aurmm,u> ul'thonimo.. ndtich shnldd :J- svnrc hc catulruclia9 arc oficn thc Ilrsr tr<I uf'Jhc idDa. Al.wi„il Las breu saidlthas lo vnitc i. w.lllink.'I'Lc caq' acl u0 v. riling dus.u :u: idra will u+anl lc dnril'c. il, .md oflnn, xuy5rst iiupr.urvmcuts. I°unhcrniurc,. :m idra unl.n cl: rspL inrd w uttim5 iCauqlhiuC. is.la canic u( iL Far pntrnt purpu v.Ihrrcc.rtd'-nf dlc.idvn is iinpar- lant. Quitr ulic•n, Ihc uriv;insl idta is uxlilird :utd is applir:nianv Irruadvucd. (:h.m.rsand adcliliunv nlmuld be nxnrdrd scparalulv, andldatrd and .. i,nr~ud as:w.ta lhcuriciusl idna.'1'h..c trcurdx rac.hli.h .lata nf run- ecpliun oud cleinr ulL invanwnhip. I1ath utny lalcr hrrmuc uf Ivlnulq impnnanm if thc idca nsautres,iitlu a s.urllndrilc inccmian: Affcr Illce idea linslia•cn dccrtupc•d '1'hr rnuiilrrr mu.n bc lonwa wilh 6irna-lf :vudlu: rraxma6ly.wr dlol hi'. iJca Il..a nul Ahredy Ixrn pla- pu.u~J I,y .. ' r - I i.c . Ilu in ptr.umrd w IV Luuwl- alyr:Jilr iuIli. IkLI .mA be I.uorIlaf ouh priot wurk, puhll6hrd Iiotllrrwur, dt.n uuehoh.u.o z I.rnriu.+,.un hi. id,.r. \L~a it ermor. nwko il mp..uur¢ to lrrpup srilb r Jr.rl.qpurun .wd.:ur u.u.dls c~paLlr ul judginc svlirlho au ~drni. h:dh" an innu.-:nimt. 0000998'7
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ABS TRACTS_ REPRIINTS IN,LIBRP:RY 7283 Fujimoxi ,~ T.. KASU9AF. ~5v Kaneko, H. Noguchi, M. Phytochemistry 1975, 14, 2095• A NEW ACETYLENIC DIOL, 3-HYDROXY-7,8-DEHYDRO-B- TONOL, FROM BURLEY NICOTIANA TABACUM T 2t 1. Fo1ck,. J. Lees, M. Stanley, G. H. S. Journal of Biological. ChemiAry 1957, 22'6, 497-509 A.SIMPLE METHOD•FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES . P2'^,c°3.`„' I'rankenburg, W. G. Advances in Enzymol'ogy CHEMICAL CHANGES IN THE HARVESTED TOBACCO LEAF 1950, 10, 325-441 0 V N'I-d Sato, Inoue, Sato, K. S. H. THE SYNTHESIS OF 2,3- ID I ME T H 0 X Y- S-M E T f I YL -p- BENZOQUINONE Chemical S'ocicty, of Japan Bulletin 1972, 45, 3455-3457' 00010023 1001 ,;.,,.. . VOL. 6, No, 17, SEPTEMBER 17, 1976
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ABSTRACTS ABSTRACTS Journal of the AOAC July 1976, Vol. 59. No. 4,, p. 941 DISTRIBUTION OF AFLATOXINS'IN SOME SAMPLES OF PEANUTSI D'Prossimo, V: Pe Nnrall, oaeoning C'.eNma.lnn. Inee found ae.Pprcaimetel>3U rimea rhelbelof B'.aBa. . sosilu in ene br.of awer.d, h7.enhrd~'peanuaa, OQdd nlelhnda, anwell of hiich,pre..ure Ii,juid ' ehaemen>gnphy, were urd ao mnGrm thi. Bnd• B1g. Addiuenei ruutine aemtde'.anal.eie data of av end roasreed pe.nuu se..eded th.rahie6nd• ' iq Y..upt w ueud n furmcrl> thouohuIt eu foend tliat 9A:A: of Ihe raw.peenwaampln eenlained hipher levd. of C ahen B.ellaroxinl 4.9% :i:onuin(ng2-E lilnea mnre 6 than B etl.radna. In a rmaBer wmp9ne of'roeared yeanntr,. 28% eff the em.unlinaud' peanun eoeWncd anoee C IIimB dleloxhu Journal of the AOAC. July 1976, Vol,. 59 No. 4, p'e 866 " IUPAC' COMMISSION ON TERMINAL,PESTICIDE RESIDUES Kearney, P. C. The eighth meetingl of theahovx:Cummitsiun of the lkaticide.Scution ufthe AppliedlCliemif+ tryDiviaion of IliN.aC was held.et ICI 17antPfotection Ltd., Jealuu'a Hilll Rerareh Station, Braekuell,. England, Oct. 2, 1074; undcr the Cheirmansilip of K. B. IIiB. TlmfolWwing aa epunt of.lhe proemiings iebad.on the:minutee of tlrt meeting and on the eplund,ces draw•n.up byy memtirrs .od pxuciate meudeta.of tlx Com- michion asuld,cattd. The f:amtnisiue clansidertd Iho report of the Joint FAO/H910 )ItetmR on I'eeunlde Ilaidua held in Celwvas in Ukemlier 1947, in, whichaome probiems eoncerning termiml rrsiduea.en dueusxd. VOL, 6, No, 17, $EPTEMBER 17, 1976' Tobacco I'nternational September 3, 1976 Vol. 178, No. 18, p. 35 TILLAGE AND NITROGEN INFLUENCE ON ROOT DENSITIES AND YIELD OF' BURLEY,TOEACCO. Zartman, R. E. et al Budetobacenwas'gre.ninlkldnbts:underconventipnaland tlpt)Itege collme.m Crln•ninethe ,nlluence ol N fertdlutmn and BNge practke.on. mot pitmibuoon, peld ana narogen a¢umub- --gIM. flool densi4et w'ere mosureG biweekly between /uly, 10 end harvest at:10: 15, 23. and 30 cm radial dislancesfmm the '' 94antr in 15Iem inerements to a d:Hn ol.eA em. Plant sampks re2 takenn coneunentlylp determina V/ant anll 1ea1 weiFnt and N epntent No diflnence wae lounpd in rnotmg Cepth Cr'rathal ee penaion with h!laee trealment or fertility level, nut the 90 k N:ha eprleentiUnaltillage treatment had feqnilicalllly kiener ranteerlslty ' than did I/le 90 kg Nrlia noiNllage Ircatment The means of leal n'eight, leaf N, p!ant',wd4kt anp plant N..at the 180 kg N/na teneentiMatlillage treatment were cVnfistent!y greatlrfeian the eUer. Irealmenlt whi!e kaf weignt anE N content of the 90 Mg N/N nnhllage treatment wera naa Inan Ilb otnaer'trealments. Cancer Research September 1976 p. 2973 FUNDAMENTAL CARCINOGENIC PROCESSES AND THEIR IMPLICATIONS FOR LOW DOSE RISK ASSESSMENT Crump, K. S. et al Yariou5.possible models of carcinogenesis are analy[eM wilh respect to low Eos•e bnOtlcs. Tho.Imporlanceof back• ground carcinbgenesu upon Ine shape of'Ihe doseve sponse.curve.at lowdosels emphasized.ll lsshown thall if earcinogenesls by an eaternal agent 2cls addltwely wlth any 6lreadp4ngeing plocess„then untleralmost any.moCalQhe response will Ihe linear al'low dose. MCasWeS of Ihe. Genree ol.bnearrty are obta/nc0 tor multistage models of caremo• genesis, whcre d i5shown that tprougltoulqhe dose ran02 where tpeeztra risk IS less Ihan Ihe Spont90caUs:rrsk linear etlrapolahon musl be gultee accurate. aooiooos 987 x
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Ae ''.VTi. \AVTS.. ABSTRACTS , ) 1 S ,e.r„rJ et ehro.rwraeraPnr. l23 (1976) 791a95 . ~Etseriv5ceotifw Publishins.Compsny, Arrsterdam-Pdntedd' in The Ncdisrlands CHROM.9060 I QUANTITATIVE DETERMINATION OFCAFFEIC ACID ESTERS AND CATECIIINSHY DIRECT MEASUREMENT ON THIN•LAYER CHROMVa TOGRAMS , MANFRED'HANEFELD.ndIKARL HERRMANN JndtWrctfaalCMndrtrr:Trdrnira(V.:.errLYUtRama.n-W nYr/ lGrSbYrY1I,JCOOHr9/MYIr(O:P.R) (Fim.rscdvsM October291h, 1975; revised nnnusaiW reaised January, 21st, 1976) - SUMMARY A metHod is described by which the main calfeic acid esters (chforogenioc acid,, neochlorogcnic acid, rosmarinic.acidc dicaffeoyllartaric acid).) as wrll as the - at<chinseanbeanalysedqoantitativelybydlrectmeasurementofspotsonthin-layer plates. Aecurate.determinalion is possible to lowcrconcenlations of I mg per kg{or ehlorogenic acid and 10 mg per kg for catcchins. The method was applied successfully lo various fruirs.and vegelahleseulticated in Germany:. - ,oarnnr n[Gbomumemnhy. 123 (1976) . )96-799 0 Elsevkr.achntllie Publishing Cumpanr, Amsurdsm - Rintedio TheNcthrrlands C7DIOM:9213 Note Thermionlc detcctors in gas chromatography - Selective.detection of phosphorut, nitrogen„and sufphur compounds NORMAN MELLOR. /nywria!';ftirrnian( Idnurkr4YnWeJ,.Orpn'rs DHiaine, Ne.rqrnn JJovr., B/wxkhr. JJanchr.rer (r'irret "alq) . (Rtteived.Febrnary9th,19T6) f Tlirihcrmionice dnlccror(TD),.somctimcsrcfcmd to asan aikali flrime,ion- isationdetectoror aa nitrogen delectnr. has been used insumhinntinn willlgasohro-nlalogrnphy since 1964, whcn GiulTriila' Ihurouphly invicetieatcd ils.behaviour.ands determined th<optimum opcratine ctuulitiuns w8h respect tulhe selective deteclion opphorpliorusalid ehlorinc II<terJ atoms.5incc thcn, tliu TI) lias bccn found capablc o6dctecting nitrmxns and'.nuw it is used mainly lur, the selmiic deteclion.uf urgano- --phosphorus and'orpanomtropun cumpounds;.itsscnsitisity tuuards phosphorus is scvernl urdcrshicher Ihan thal.of Ihr Ilanm iimisatiun detcctur (I:fID) and it has a vcry highda~ree.of selccGviry wilh respen to hydrocarbons aswcll.'fhedntceti•r it is <ILimed,plso resnonds to siheon, sulphur,, boron„arsenic, amimony; and bismuth, althoughto a muchlesser'dcgree' ` 'Ihispaper repotts'J~he use of a commercial 71D (CSC Uiticum) nhich has been luned lo,give.a high detection srnsitivily tuwardrurpnu.nlphur. The sensiGsity. is rreater tltun that eirich can be obtained fnr niirogem,hut less Ihan Ih.q4i,r phonpllorus. ltal;o shows Ihe.rclhtiurntiip.betsscenuhe It).Irngen Ilow.rate and tbe uptimnm olxr• ating enndflionsS fasr detecting sulphur, nitragen, and pho.phraus hetcm atumb. 00010015 VOL. 6, NO( 17, SEPTEMBER 17, 1976 993
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s ABSTRACTS CURRENT CONTENTS Frerenlui 2eiUChK(lfur .. _ , ~ Analytische Chemie . Atticks inf{nglish or German- Each Abstract in[nglisL and German • VC1L. 280 No. 5 1976 W.Heinemann 3+9 Delerminationof'NobleMetalsbyAtomicAbsorption Spectroscopy. 3. EHectof Platinum and Rhodlum on the •- . . . DeterminaGoodf Palladium (tn German) H:I.NIlmisch.D.Ambroslns 377 Qoantdative0eterminationolBonzo(a)pyreneInCigarene ,. . Smoke Condensates by.High Pressure Liquid Chromatography .. . ' . . . • ' [n Gcrman) , .. ' . . .. . _ .. . . . -- ~. .... •,..rr: E ;~<) 66 Ezperi ni enta l Gero>itology.' ;:. :irticlesin English-Each Abstract in [nglislq Frcnch and.Ccaman~. _-... .,.. VOL. 1.1 NO. 3-4 1976 ., . :: .. •, W. S. Ri:kcrtand R'.,F..Fonces: Changcs in collagcn:with age-VT. Agr.and. ;:..• ..:: smokingrclatcd changcs:in human lung conncctivrtissue. -•--`-.. 89 LiRlTESH'. ML-llfCAL JOURNAL Abslnactsin lasgllsh . .._ VOL. 2. NO. 603W FiUGULST 1 9.1 976 iGeaoufnrmnk.rAewinre"mun.mns:np uel.rleurmW....n.hrra~otpnne..LLAdr.er ". Menl,cyrt4Cw~uuv.<mnuu[w.r~~rrt[ ..........:..............................................~....r::Nl NkNlr:u..n..Wn~nM.MUr.W •• •• •. • . Y.[lu 1rmYnp. a aN'.C:.H k4rcM. ~r: r M .i.•,v. ...... ....... .N. nY..i6••,ilnJ.l.•m,n T U slu~. r,m .......... .......~.....rm ~ a jp,rii% tl, o/-drr,{tJ/'RJ(JLk ~,~... ~i~.~~~ l',iiiJl~l:r•IJ....ai,• Ab~tracn in F:iscti..h VOL. 53 NO. 7 JULY 1976 480-494 Ikternueariun uf 1'0, Cu, Ni,and r.brin P:ns and Cilt by I71.nneless Atomle Absorptinntiluarnr;ol'Y. by11S. OlaiAn 00010018 VOL. 6, Nor 17, SEPTEMBER 17, 1976 996
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ABSTRAC. d S ABSTRACTS Cancer. Research September 1976' p. 3025 INCREASED ATTACHMENT'. OF NUCLEIC ACIDS TO, EUKARYOTIC AND PROKARYOTIC CELLS INDUCED BY CHEMICAL AND PHYSICAL CARCINOGENS AND MUTAGENS Kubinski, H. et al Significanlly.enhancetl attachment toEhrlich aseites and Fscl/erlchia call cells was observed lor.radioactlve DNA and. BNAin the presenceol chem¢acmutagensand: ullimate carcinogens. in some instances. /ormation of nucleic acid- prolein adllucls by these compoundsJurther (Or similarly). . enhanced''the binding. DNA irradiateolwilh ultraviolet light InJhe presence of a proleim bound more efficienlly than either an unirradialed mlxture:ol these two macromoleculesnr DNA irradiated alone,. The spectrum of conrpounds.' lpsled and round active in tbls system includes alkylating agents. aromatic amines. and.carcinoganic mclals. Precar- cir,ogens.and nonu8imale.caror-.oqenlc chernicals, as well astumon-promnbngagFnts..drd noa increasc Ihebiaoing: However. adddion ol'estracts Irom mouse or lat livers aetb valed1preca.clnopenic and proximate carcinogenic.ceemi- CalS and re5u11Gtld in Cnhanced cellular altachment Obmditatornucle/a.acros ir their presence. Possible.u5etulness of this lisl syslarn for last and'etircient screening lurenwron- /1lenlal ca'clnoqens and nlutaqerl5. as well asposslble rCle- Vance ol-the observed phenomena to in vrvo effeclsols Chemical and physical carcinogens. is considered. Journal of Chromatographic Science August 1976, Vol. 14, No. 8 THE DETERMINATION OF BENZO (a) P1rRENE IN COAL TAR PITCH VOLATILES USING HPLC WITH SELECTZVE'UV DETECTION Boden II. Abstract AJsorptlon anArnverse•plrasa.mlcro~pnrllcnlnla.cnlumns h>vn benn usuJ In cuntunrtron ullr ave.rlanl. wnrulrtnptM1 l/V tlulnelW In Jerulup ^.ensmrn rmOseloeluo /IpLV' peoc••amm lor IM1n rlclarmlealwnul Lonrn (:q pyrnnn ItrcnnlY: r pncn volnulnz. Ihe prm:~mw.•s wam .nludtrM py alwro.ne Ihn Ylulinln cluunclwisbc. of : mn ol Iliv mrtWr puly.ure4'nr arUmntlc hytlmcnraons w/nch mn Anawn ru bu nnneul .nJ: Ey CYmymifun wilh a well-uneblchod LC-W pmcwlins. VOL, 6, N0, 17, SEPTEMBER 17, 1976 Cancer Research September 1976 p. 3350. MUTAGENICITY, AND CYTOXICITY OF BENZO(a) PYRENE ARENE OXIDES, PHENOLS, QUINONES, AND DIHYDRODIOLS IN BACTERIAL AND MAMMALIAN CELLS Wislocki,. P. G. et al Twenlrnine tienzo(a)pyrenx derivatives were tested for mulagenic:aclivily without metabolic activation in Satmo- nella'.typhimurium strains TA98. TAIOO;.ano TA1538 and in Chinese hamster V79 cells. The oompoundss studied in• Cluded 4 arene oxides,:all 12:isomeric phenols. 5 quinones, andB.dihyprodiols. BenzoWlpyreneA.5-pxide was the mst'mutagenio ol the: compounds tested in both the bactermo and mammalian syslems: The other arene pxldes. (benzo(a)pyrene.7•8-, 9-10-: andl /1,12-oxides/ were only weakly mu'agenic.rn the S. iyphimurium str2is. Hovever, in Chinese hamster V79 ca115. benzo(a)pyrcne 11,12-oxroe was as potent a mulagen as was benzo(a)pyrene 4.5mxide. Among the phenols„6hyoroxybenmla)pyrene and 12hy- droxybenzo(a)pyrene:were mooeralelymutagenio in strain TA98nl S. fypNrlurium, and 6-hyqroxybenzo(ajpyrene was moderatelymulagenic in V79 ccrls. The other 10 pllenols.5 quinones (penzo(a)pyrene 1.6-• 3.6-, 4,5-, 6,12-• and tt.12- quinones) and 8 dihydrodiois (benzo(a)pyrene crs-a,5-, frans-4.5-, cis-7.8-. vans-T.8-. cis-9.10-, rrans:-9.1'•. uv- 11,121• and Vans-11.12-dihydrodrolS( were'either inachv0 orr onlyweaklyy mutngenic. LHydroxybenza(a)pyreneano 3: hydruxybenzo(a)pyrene were weakly mutagenrc in strain TA98of S..typlrrmunumi and beezo(a)pyrene'.1.841hydro, dial was weakly mutagenmc in Vl9 cells. BenzoDqpyrene: 11•12-quinone was exlremely.cytotoxic lo.the V79 cetls hut had no.observablo.toxicity inlhe bacterial slrains. 00010012 990 \ s
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ABSTRACTS ABSTRACTS Journal of the AOAC July 1976, Vo1.. 59 No. 4, p. 938 GAS-LIQUID CHROA9ATOGRAPHIC ANALYSIS OF N-(4-CHLOROPHENYL- N-2,6-DIFLUOROBENZOYL) UREA INSECTICIDE AFTER CHEMICAL DERIVATIZATION Lgwrence,. J. F. & Sundaram, R. M. Sr iFe e..liaoid'. duomnopaphie .nal>da o( Tf 6010 f•~'-Gl.hlurnphmrl).A'-(2,bJ:BUOro• benmyq:urr.) we. carrird out',.fmrllac.InsrNi- etdr . nrMea to it. N,h"-dimelba unalos (:1.medla _5-(a<Idornnkenrl)-M1"-mmlrvl-N'-(2, 6-0i0uorohencmiyureap. Tl.e mrlhylanm.u .eeumnli-llyd in n]S51Y with radium hydride arrd mrtlrri iudidF.lLe deriv.tive.aa Ibennutl, .talde and chromsl•rorapl.d aa A ainFle. Fe.k n'37e O\'-1 .r 235'G.Supporl fae Ihc •Irualusw ot Ihe prvdn•s s... p!.m by n w.aneurromcMry..Tm renriliviV nf Ihe pruducl in rtctt*. Irolaic mndncG.Nrrdmec.Mn was .pnroal• mxeb SO.n11iu.50 .% fuil-.r.le.de0ealiun in the ninsen urod•- ud 70. ns fw tkecama, rnpon.. in tBr chlnridr. (rrdnaire)' molle, Abuw 0.25 nn...c required for SO% fdl-arale de/4nion'h,. .-0atrnn vanlnre (.1 1 x 10-• .rnp alandina r mnl. F-oli.ae eamplea . Isaed fur TIt (A10, ucina Ihe Ilrotunld n Ihrd. American Review of Respiratory Disease August 1976,, Vol.. 114, No. 2 p. 297 TIdE' RELATIONSHIP BETWEEN SYMPTONS AND'FUNCTIONAL, ABNORMALITIES IN CLINICALLY HEALTHY CIGARETTE SbiOKERS Dosman, J. et al Iln I.a mM1r or" ..Is Icaf nr.v L+nuvl lu.l....aue vLnnmvlilir.rd Ir.nv' fm¢IiooSn ti,ln/h' t I . r -l -/1 I. -1 ILr, r ln . r IY 'llul nlra. . u. np. IuR. nA shnulu nl I.nr.nlr rn en ............ lr n.l nr udr s dil • nl,r tl ,. rl ~ trinl r, m . ,l•I .•Ir Im I.•I.uJ wllh m u nu . rr n rl. r•I Ilmp LnnGr~n Jlul ar4•lir.nl 1• Ir :rl ,.Itnr nr n. nrnl•nr. I e In• ill '. tn'+ r rnl Ilr•' In.n. n.lfr. .n.rl~,rrn lu' ~'•Il.nl Ihr nArrv. Indi.idnal .anpu r.....uu.adv.mlar nn I/.,ol.l..nn n rvli mrl s m.n. ...•Iwr•uu.ns .l F Unr.l. el ll.•we.w• . dll•r .... ....... ISULre.for d .uamn hn otsln•t.u,l n .urlalydpanKr. ./ 1 In, solunn~, J:..iug up.m., .l•yn. n.,I 1•Ir,rw' IIII ml Irrlmm tlm -hm.r urs.o. 11 v .slnplum. ~. IM... al'. id In 'm nl . uF n........ .rl•d ppnr{s tr- urrll wlnrJrn ,',1 n., ul a'.pll l upuit/.llunnlnh..,llr.ruau.r u,pnn.nlJU.nr ..r/nura Irlnnlll.alnr.n-b rulnucol lnup lul n .armr. l. lllrrl.rlhn Iorn b..v l..l. wdl pu u r. , atrd ' llun ....... l.•nn m rall.mrl.rl al IiJ' m rMs.vlnp rlu.rr....L.nnnnrp.llr.r.urusr/h.1.v..cluqmm... Y...... w lie n.l l.r darrl n,.•la.wlnr arr I1.1,Ir /n tlr.f L/nannr.l alnl•nm:drnrf .alr„r•llst' nLIn/1dIVrinlKl~ .lallv.a\IJr.nnrl VOL1 6; NOt 17, SEPTEI-1BER 17, 1976 Tobacco International August 20, 1976 Vol. 178, No. 17, p. 16 . INVENT'ION'PREDICTS "TAR"' LEVEL OF TOBACCO CROPS BRISTOL,.'ENGLANo--A W.D- & H.A. Wills im'cntionl wliich can. predict Ihe'-Iar" Icvals of crops of tobacco•,is in dhnlanJ by'scicntists on both sides of',the Atlantic. Three are already inn use in IHe. United Kingdom;.a foorth.is in operation _ bytheAmericanLcnfOr,nniz:nion in North. Carolina. i\ow, three more for America are beiag buill at the Wills technical dccclopmcnt unict in Bristol,. England: Tobacco International September 3, 1976 Vol. 178, No. 18, p. 39 SOIL-BORNE TOBACCO MOSAIC VIRUS AS AN INOCULUM SOURCE FOR FLUE-CURED TOBACCO G. Vr.Gooding, Jr. & F. A. Todd SoibLnrne IoLSCO Innsaie vlrVs./(MVI ia 'moO/tantsnmce !f iml.u,n fur II,IC{Vlfd IcI:J[00 iniK':r[1 (IarOlin,l, D.`chuctlon Of sl:.lkslnrl rw14I:y lull nlrrn.nn /ullcxed nY. ViXlnn a,rp nlrnl- irl/! -leron 1¢tl C nL 1 tl;v nrl/ r.i1C (FC/" llnn Of, TAIV- I/e soil. p,1 ' YI nCG IEI['.nsni[M1 as .U..of 911 . IoWccaCrun in MorIM1 C.unLna nlrv nCln/cctr0 r.-dM1'.T1.14'LY Ine~ omnlraion o.f /lnrvest. Il~cu!.c olre-,xtanl eulLUari'. in "prnnlem'• /ields Is a••Y'%eslyd ns a mipns n/ aannnng soll-OOnle moeulam w11CIe.InonqcullYla I] CorlllllOllly /p]clrced. 00010010 . 9€38 a .~:
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ABSTRACT S ABSTP.ACTS a Cancer Research September 1976 p. 3358 I MUTAGENICITY AND CYTOXIICITY OF BE'NZO(a') PYRENE BENZO-RING EPOXIDES Wood,. A. W. et al Four bonzo-ring epoxides 61 theenviionmenlal carcino. , gen benzo(a)pyrene ((iP) were tested.for mutagenic and eytotoxic aetiviry' in 3 strains ol' Salmonellarypmmur/um. (TA153g. TA90:.andI.TA900) and in Chinesehamster V79 cells...Alttlou9h veryunstable.in equeous solution, 71f,6n- . dihydroxy•911;101/•epoxy-7,8,9.10. lelrahydrobenzola)py- .rene (dial epoxlde 1), with me.7-hydYoxyl group on the same. faceot Ibe moleeule.as the.cpoxide oxygen, was 5-51o4 times'as mutagCnic inAhe bacterial strains as was nss more stable stercoisomer 7U.&.-dihydroxy-9,..10/iepoxyd,8:9,101 lelrahydrobenza(a)pyrene (dipl ep)xkde 2)- Im V79 cells; dial epoxide T had onethird the mutagenic actrvW of diol epoxide 2 but was al least 10.hmus more labile than dial . epqxide 2in the Irssue culture medium. The hall-ple of de01 epoxide 1 in tissue cu0uree medium whs about 30 sec. whereas the halldile ol'dtel epoxide 2 was between 6 and 12min. 9.10Epo.y-7.8 9.10t9uahydrohenzo(alpyrene0 which is saluratediin the benxo ring. is also very, unstable ane has mutagenic activity equal to.or greater than dml epoeide 1' in Ihe.baclenal and mammallan cells. 7,8-Epoxy-7.8;9I10-tet-rabydrobCnzolalpyrCne was.morestable in aqueoussolu- lion than any of ute 9.10epoxMes of 6Pbut was much less mutagenie in both the baeterial and mammalian cells. In. V79 eens; mol epoxides I and 2 and 9.J0-apoxy-T.8.9./04 letrahydrobenza(O)pyrene were mme than 40hmes more. eylomxiec ehan 7.0-cpo.y4.a.9:10detrahydrobenzo(a)py- rene. The mulagenicny'oI the 21Ctrahydroepoxwdes toward", 5train TA98 of S. typhrmunum was readily abolished bypurilred epoxide nydrase. whereas the mulagemc aabvityat the 2 diol epoxides was.relatl4el, unalfectedby comcu+ bation with Iheenzyme: ' . C&E News- Augue,t 23, 1976'. Vol. 54, No.. 35, p. 9 0511P.hasdelelod one xuspeelud-earclnagen job heallh clandard iuxl(wx6nns of 10 c:hcr [xcinocan staixtv[ts applyinq In 4.boraloinv u<r of Ihc.chemic:ils (rum We Codn of Pcdcral ttt•md,Viorx. Thn.staivCvd dclrlealin 7ts.enlirely rlenls witly d •1'-m~;11ry1ene:uixl~-rllHrrro;~ni- line), ur h1pCA. 1 flnI:,huraturyuse . provi.;lbnshnd covcred:4-nilrobiphcevl;, rr-rnphlhPl.immc; me81v/ Cldnrenlnthyl elh<vi 3.3'-dlchlnrobenzidirm; bic(ado- romrrtllyi)Othur; If-naph::tr4emin¢ bcntiWnO 4-ammo- dil+lrunytl. rlhyli•nrinm:n; r(-p, opiol:vlnn.e;.2-er.elvla- nlinol4nnt•na: 4dutmtlql.umunazntMnlCnrr, antl IJ- niirOsodimrd.yeimmct l llr• sLmJ, nu: wcrn v.~ca!nn by fr'U.S, l.Ppans Curnl mdte:cum;mr 79y4 an10011 IA StuPl>ml r•ntnrcirvj Ihcm m J. inu.vy 1975. 14R'Ithns )u:t gpllta nmmldAO dalwnlg Ihom o:licially. VoL1 6, No1 17, SEPTEMBER 17, 1976 Analytical Chemistry September 1976, Vol. 48 No. 11, p. 1464'. SIMPLE INDEX FOR CLASS- IFYING MASS SPECTRA WITH APPLICATIONS.TO FAST LIBRARY SEARCH'ING Dromey,. R. G. A simple.Ion serles-related.Indexhas been developed for. elassilying mass spectra. The Index restricts Ihe choice mmolecul.:r classes to vrhirJt a spectrum maybelorgy lntmalass vmiatlons can be conNaled with slruclureldifferences v:hileInlnrclassvarialions araderF.ed Irwn the influence of diflerenf/unclional Woup.•.. The specilicily o/lhe index malres it Ideal /or structuring and searching mass spectral libraries- A htrary search scheme which retains the claes delinition of the file.aad. still yields a1a36 to an urder.ol magoilud0reduclienin Ihe, search epace is described. American Industrial Hygiene Association 3ournaL August 1976, Vol. 37 No. 8, p. 474 A. STATISTICAL TECHNIQUE s FOR DETERh4INiING COMPLIANCE WITH DUAL HY.GIENIC STANDARDS Brief, R. S. & Jones, A. R. Rcccnt USIIA, propnsnls indic:dc IhnD indUS- trial hrhirniaswill ht f'aceJ wilhxn inercaaing mun6er nh stnnJarrls huvin¢ hnlh :1 lime- wcichlcd:n•crage( 'hA\'.A.) :md aCciliiu! Limit, tirc l'.IV.R- s/enJiud oould apPh, lo an Y.-hour wnrkJay. "Ihc f'cilin_ rdec wmild lic uwJ fhe Ill lu IS Ininutc-tinloperlnd+. Ry lakinr,':a9casl h.o r.implc.. nf cqual sntnplin•, limrz. cspu:.urct c:m hc er:duaL-d witA rc.pect ln boJl Iiveieni:. slantlarJs. lhe s;itul}Ics rxl:n• ' Iwcithrrcunseyulicc.orrandum.. ' . 0002000s '.
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_NEW LITERA:I"URE. BOOKS RECEIVED AUTHOR: Wiswesser TITLE: PESTICIDE INDEX AUTHOR: ASMS TITLE': ANNUAL CONFERENCE 5th ed. Entomalogical SHER ON MASS SPECTROMETRY : PUBLI Society of America, 1976 PUBLISHER: ASMS, 1974 AUTHOR:, NSF AUTHOR:, USDHEW TITLE: CURRENT PROJECTS ON TITLE: SCIENTIFIC DIRECTORY ECONOMIC AND SOCIAL...1964 AND ANNUAL BIBLIOCRAPHY •PT]BLISHER: NSF, 1965 PUBLISHER: USDHE;;', 1959 AUTHOR: NYAS TITLE: ANNALS OP NYAS V. 273 • PUB.LISHER: NYAS, 1976 AUTHOR: Jones TITLE:. GREENSBORO 27 PUBLISHER:. Bassett, 1976 VOL6, No., 17, SEPTEMBER 17, 1976'' 00010035 1013
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ABSTRACTS 85r.4G082m Cyclon[ilphntioc unsaturated ketones as odai- and taste-modifying alteats.Kirvnls; l.minf i)cmole, ISdhnard;. Uhloff,.Q;umtther; Stull, %Inx. (Firmenich S:.A.): U.S. 3,9:25;456 (CI.'160 -586R;.C0DC), 281)ee 197.5, S::iss Apld. 15.667/67, 09 Nov 1967; 34. pp: Poly'methy1 (unsatd..acyp cyclnhexenes and. -cyclnhexadienes and.pnlymclh,rlbicya:lol4a01nmta-2,8-dien-7-ones and.-non-8-en-7-ones wcrc pre;>1.; the first 2 types of ketoness were useful in floral perfumes and alh 4 ketone groups were- usefnl asflavorings ager•.tss for fouds andd heverages. (cnmpns: given). '1•hus..1-(I-hydrnx)-3-butenvU'-2.fi,6-Ltimelhylhycluhexcne was oxidized byCraUs to 1-(3-butenoyll-'L:6,6-trimethylcyciohexene, and'i this was isomcrized by p-D7eCr.H.SOzH'in benzene too trans-l-crotunuyl-2,6,6-trintethylcyclohexenc. which increased the power and ricltness; of floral perfumess and was -used in tutti-frutti flavoring compns., in flavor compns. forr monastery type liquor,, and in a soln. whidrincreasedh the aromaticity off black tea: , ... 85: 3+931z Carbohydrate chanFcs in invert siruus: Velhscn, Viuli•to. S.: Ilowling, .Ioseph. F. (hrd. Div., (71:'O'' lht. ]nc.,. Ynnkers,. N. Y.). U. S..,AUrir. liun. ~eru.•.Sr;af!i:[1'.=p.J'.. (Y7:., Ad`.&S-:4 l.",:i57 I:7il,-):. 'fhc inczn.ian u:' a::crcs( (!)'. [57-50 1] wlth,HCl(71 fr-01-11[ and mt ert-we li'.1) ("01h1-tT:)gzveinuc.rt su7;ae[h013-17, Ir1 :,irupr which cnnevmcl. lcsx fr•euloa• (1!!) [574N-7) Chnn demtrtxre (IV). [51!-S" 7.] a.derai bV'Frs-1!qy und paper clirntnatog:. 11i wes mure ser•sil.ivv ru Lh:r, rrd : r.aliun.s u ,s r idr•nti i.~lns« I bv diimhidndc n iaumer rn under ad nnd ehromato{g. Iinvcrled I wil!: . It umicrwcnt lt•ss de:.truutiun of I I i'. emuli,inne, respJ, and hardrnrr 1.0 ;mr;, sprrnd in the f.rt~mu,s 3 lm•ers, and eonrprr-scd;n a.Ihe:et dd prrn, fur I: -2fi, srq':mn at 1110°°fiU° to I:ive 3-piv chtphuari -silh inqmuiccl lirc rrsisumce. ~85: 45172d Food and Cosmctins.'I'achnnlmb', Vol. 13tduppl': A(onolRaphs un Fragraa:ce. 14w Slalerials. Opdyke;, U:. L. J. (Pcrgammt:. lilmsfdrd„N.. 5.).. !s1's. 2i3 pp:.- . . .- 85! 4GL'15v' M1icthyIdiaxnbicyclnall:nacs, llenrv, I)avid W.; Sturm,Yrisci.lla A. (titanfnrdi L{esearchInsti.tutel U.5'. 3,"51 ,PN6 (CI. 560,'d6bf3P; C0:(D751l02).. 20 Apr 19713, Appl. 468;370, 09 klay1974; 8 pp:. Division' of U.S. 3,905,979:. W t4 a- -M- -n l a'to ~\af'04ta u. V Dietl:ylcarhamazinee anniocs 1.. II. 111. and. Il' (dI =' F.teN6:!], COtlal. i, il,nnd Ili! liil= 1•,ttii,iCUi,:md 1(lt-p'aobexyir.ci:,nyb. and(or) thcir HCl salst"U cumpds:), usctul :ts hrwrrh::ddamrs anrl mu'ilihuial agenls (no diu.tl, atrre prcPd. inii3 97 % vitRds l.vy acvlatirqt nf Il 11,. 1l1, :utd IV 112. = I-01 with 1{IO;CC71 IaNCp, nnd'ce.e!nh,•sxnecarhunvl ohlur':+e. 1. IL 111, and Il'IiI =l il wrrv prrpd. bv .1 nruth..l.. I'hus: DIuN1I' hcatt•d rrith mc..o-llitQla'lllirl'iGa_ at Hn'nvcnnit:ht ttii'.b)I Ihr p;rrnlidinr rik-V'Ut = 1St. Iir = Ft(1)retllrsed n-ith 1'i!C}Iin Wcl:v r' br,, tho nmirie V iit. = l:t:. Ilt' _N11Cl1 Ihl .apmidtlu wd V(R = It: If' =IM1L'i1-1'Id, eydlzed hl "1; clle 2.3 b andrnv. ol' I llb L.IG.l'id n•duerd' (Liallidt61i : I,;md 11 diaanbiayrhnn~WneLlli ~CIi:C'bl•GI!CI! hydrulumnecd gara ,u,:. I llt'= Itl: 85:40T/Gj I•;ffeutsaf S-15:11 (llitolterol) andiS-15'J1, a newbronchodilator ondrachoo-hrunchiid muncle and~cardiovasculnrsystem. Ono, Nnbufumi; Nushiku, Kazushi; hlnrishita, Hidezi;. Nakagami', limwnari: Nnkaliarn: Tamio; Furukawa, 'Patsuoo-. (Sah. pharm. Sci.,, FukuokaUniv., Fukuoka, Japan). Nippon. Yakuriguku 2asshi: 1975, 71(7), 739-52 (Japan).. Tllc: actions CMIOn)CNrMNdyi: II of S1540' (bitoltcrol) (1) (30392-a0-ti[, a new bronchodilator, and its motaliolile, S 1511 (11) [d7G5-tl_'-4), on thebronchial smooth muscles and car.m.vascu6r svstems were cumoared withthoseofi.coproterrnol(71iSJ-59-21andmeraprolerrnn! [58.6-06-I) in rabbits,.dogs;.and gum 't pigs 111 snnwrd.rhe strnnrest and fI showed the weakest relhxungeffcct ontl:e isolated rtnnesi pig, tracheal muscle.prcaiunslv.cnnatricted hrhirtamu!c. 3a@'!t: andi aeetylchulina All theec dru;:s cirrsec,edd thebh-nd'pressureandie incrensed thr heart rate in guincs 'l'Eie wdhr nf putencvwasisupralr•re.nol > 11 > metapruleumai > 1. and thc pnte•ncyuf. I was 1/500-1/10i10 ns; much as thil of 11- No remarkahlechsnge e'as inuered b) . lhc°e t's+.:(;s iit clectrn;nrdio><rams of gu:nca pi}s. Dcpr.xsoq p.r.t chrur:atropic, •.ndd inotru!-ic uciiun;on rnhbits and do;!swere.;tre:uratl'nr kopruterrnoL fn!loe:ed hvIf, and estremciv wvak 6,r 1.. When I v:as xdetinstercd.ornC~:, I and it: metabulitell• bul!i ed:ibit hrundoodil:LLing.acti6ns wrthInne duratiun. H. A?n! 85::465.^.;tit Terpenc flt:vnrants'.and !ntcrmcdiales. ISctlelc„ Erhnrd; Sch idt•1. 1''t trr. (, nuudln C.'r,t ) U ti o9S91^-0G (CL. 260~/i011t:(U-,C). 1' 1 cb.1Ji3, .pl I .2,175• 03 19GS: 8' pp.. Division uf' U.S. :3;i7!J,1:2: '1'itt• natural sineu-alanrl itsuome.rs, usefol as Ilarorin;; nmteri:ds,.. arrc prePd. hy' 14•itG;:reactimt uf IICpCI-I~CFIM1:'acC1i1'It:CHzC1:CN:9CFl:(:I1~Iq, with. HCOC51ca'I'hx r,r i:h0_4IC31e:P1'6a, nndl suL.,-!rycnl rean.. and oxidh. •I'hos, 175 gIN:II-I. ainaincd tive hccirnlvsis ot its eyclic cthyiene ar'clal,, was rciLrxed with 11C1t(f\lo:Pl'hr in' benzene fiu 40 Lr to;;ier 757, llte natural sinens'al. 85i.•IG(17&q Prnstat:;andiin anxln~s, luhusnn,. 6fichael Rns;Hes.c; Hnns.l. B.; Scii.nl~,'I'bum:r; ISindra..Jn.iit ti. (ptizrr Ino.). Grr: ODfrn: 2,f65,i1i7lCll Cu7l'I77/(I()1', 16 A1rr 17711i. US APnI. 271:-*-'ll. Ia .lnl 17'1: 1'.17 pp. Uihisinn at Gi'. Ulai•u,.. 2,:)31,'J45. fScnlxlindilnt....... LLihypcrtuusivC and ulcrotrnyit f 0 II pn e•In; I mdm di•rivc , in, lod.uut f Ift = 1'h. 2 thcrml, ?. I Iw•m~lmethvl, C,ifl'Jr f I„IId/Ua I,!lurvhnr•LhallwrreOrcpdi 'PhrixIlit = I'lil ct t. ubteiiortl lu,nr I'hC11:C'li(91:1'N)IUSA0s artdthe h,rtrrm• I li rn 00009993' VOL. u, No r. 17, SE° TIEr.1sER 47, 1976 971 . . . . . . . . . .. . .. .. . . . . l . ,.. 4 :. ]ii.'~:~<i
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_NEW LITERATURE BOOKS . PERMANENT ProcessofImpartingCreosobilityofSellulosicond'OtherHydroxy-Contain- PRESS Ing Fofineric Fibers andFobricsby Reaction of N-4lefhylo! Derivatives in. the Item No. 6215Presence~ofPhosphoryl6fing Agents and Prnducfs isa D.epartment.ofAgricul-52,00t ture report. Creasability properties are imparted to cotton r-ellulosic and other - hydnoxy-containingg polymeric fabrics and fiberss by reacting themwithN- m methylol derivatives.s in the presence..of phosphorylating agents.. The.result- Ingfabricsare.bothheat.creasableandcreasr.resistant. PB-248.001,JuIy . .. 1975:19p.. • . . .. . The latest Management is thr.continuing literature survey which includes allreferenc.es,.publishedandunpublished, entered.inthe NASAA informatiun file in 1975. Besides.biUliographic informationtheren iss an abstract of each re- ference. Thereis..afso an author and a subject' index included. This survey should:be useful for managers, both general and special, in almost..any area ororganization. NASA.SP7500(10), 1976, 118p. VaLt 6/, vOl 17o SEPTEMBER 17, 1976: WTFRATURE FOR MANAGERS Item No. 6202 $7.25 1011 •
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r ~EW LITERATURE BOOF:S' RECEIVED AUTHOR: Powers. AUTHOR: NSF TITLE: HOW TO DISPOSE OF TITLE: SCIENCE, TECHNOLOGYr TOXIC SUBSTANCES AND AND INNOVATION INDUSTRIAL WASTES PUBLSSHER; Battelle., 1973 PUBLISHER:•Noyes, 1976 AUTHOR: NSF' TITLE;: AMERICAN SCIENCE' MANPOWER' PUBLISHER: NSF, 1966 AUTHOR: CMR TITLE: OPD CHEMICAL BUYERS DIRECTORY-1976-77' PUBLISHER: Schnell, 1976 AUTHOR: U. S. Treasury TITLE: GAUGING MANUAL PUBLISHER: U.. S., Treasury, 1962 00010034 s VOL, 6, NQ. 17, SEPTEMBER 17, 1976 . 1012 .
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11 ABST RALCTS ABSTRACTS A.rnro/e/'C/roummprayF.,123(1976{417-RS- OF.Ixvicr Sciemilk Publishin8 Company, Amsterdam -Prinled'.in The NcthMands C111ROM.9073 ADSORPTION PROCERTIESOF STAINLESS-STEEL CAPILLARIES USED IN'.TIIE PRLPARATJONOF OPEN7UBULAR..GAS.CHJiOMATOG12A1'SIiC COLUMNS -H.RYDA. -psr9mr eforRnnir CArnen i-, rrml~Biuehnnisrry: Crrrhn.larnk ArrrArrnJ' al Sriemcn, IS6 /U Pruvre 6 . . fCrrrlrorluro4iu) (Frsl received Norqnber.INh, 1973;; rcviud manuseriM reeeivea lanuary.61h,J976) . SUMMARY Adsorplion on the walls ofstainlcss-slecl capillary.tubing has.been studied by means oflclulion gas chromaSoFraphy with snbstaon~ of.d ilferin6chanic:d filnctional groups. Severalpr :edures for cleaning the eolmmn walls.have',becnnestcdand their t(fcct on tlie adsurplion activity nfIbe surf:ice Ic descr i bed. Ilyy means of'f cnnl ruIIM eleaning,.it.ispossiblc to prcryzre Iuw~adsorpUvityy surfaeas. (hee propcrticsof which can be defined quite well innerms of npluity.ratios~and peak shapes. Satinfactory:md reproducible eol:unn performnn:e has bren obtained with sudaces of lhis type coated with squalanc as'.Ihc.slntionury phase. V . Juurm+l ufCl.wrwr)SrrMh, 123 (1976) 271-278 tryEt.ricrScirntilk 1'ubilshine'(nmNny:.Armlcnlam - Primed in TAe Netherlands CI IRO?L 9GJ9. IM1'ROVING TIIL EI°PICIFNCY OF S\5 ALL. GAS. CI IRO\IATOGRAI'IIIC- ,r,i)vSS. SPIICTROttfMfltIC DATASYSI FhIS UY' MEANS OF SIMPLE AL- GORi1l1'MS J.T:CLi7(Cnnd.N.51UnGR t DrJnrnrrrnr nf Osune C/vnriirrT. Suiu I"edrrul Lnrlnne nPTirlnnJnRy.: Un/rrvrlnirsnmie 16. Clf-ap06 ZI'nMi (S•ir-, rlurd) M.RF.iNilAltI> - lMroimrr.fur 1/1irr, Fr.rmurer.nN n'mer Cn/l.nhrn Cmn.ol, Sxia. F Annl /nsrierm nfTrdnrvlncY fIrA11AG/,ClidSl.tlDxlunrdnJISar:erOxJl. ,. . and R. SCI Il1'NtZIW 14C111 Aepnrmnnsof(LPniv Chrruiom,.9av fivhral4urimrrnfT hhnlnpy Uninnir.5ubunr 16,.C71: 6IXM%urfrh(.f.ir:.r.LhWl (I'inr raeiv.+d O,auhcr Imh, 1975; roucd niuourriM rrurired JmmarY IArh, 1976) SUMMARY Compulcr mclhrwlsare pre.aned for I bcnullumaliridenlilic:ninlt nf rompouud el:u.esin Fav eluum:nurr:yrhiC. mAS ~.pm :umetric analy.es. A.lnqdt :rpprr;mh is.s idluslrated I•y-0he comhinannn of I:rax chronuterl.rmw'fLe Ji'Irvtrnn nl' p.dl,yclie uromatic Irydnnarlarru I.di..:u.1dfn mure.dcl.ul.in.onler tu eIewPbly.. ihe appli. vsnutraf a srrcialin+l algnrillun. VOL. 6~ MO, 17, SEPTEMBER 17, 1976 00010014 992 U
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/`iBJTflACI J ABSTRACTS ! > i Analytical Chemistry September 1976, Vol. 48 No. 11, p. 1517 Journal of the AOAC July 1976, Vol. 59 No. 4, p. 835 STANDARD FOR'IRON,.COBALT, N'ICKEL, COPPER,. AND:ZONC IN' -- Y.ASER MICROPROBE EMISSION SEPCTROME'TRY:OF'BIOLOGICAL. MATERIAL - Giovannini, E. 6...Principato'p G. . COLLABORATIVE STUDY OF THE MICROANALYTICAL DTERMINATION OF PHOSPHORUS IN ORGANIC COMPOUNDS LaLancette, R. A. et al A feanmlcroprnbe wr used to study and lesl e melho8/ar ~. - . tM Galarminallon ol irm4 colbalt, nkkel, copper: md. zinc in iaMmal organsand Ilswaa. The rola0ve standards were real-. . - 4edon a malrls preparad Ilom a haulogenate ol raobd musc/e, tissue by adding saline soWllons a/ these elamenOln acaleE I anncenlrationfi./ater they were ashed, grolnd end cernprassed'. . . Ydolablela.InthlsvaY, workIngstraigM-Ilnerelatlonshlpsfoe b/deconrRntra11on1alerYelenelblredteasbadmalCrlafwele•e prepared. WIOdn Ihe.lndicated limits; lluse slraighl-lines are. ' Wealfar carrying ouLquantllatbeoraluallans:W theabave. . menllanM elements In anlmal organs and tissues that hava. - .. prevlausly,becn astlad• ground• and compressedlnla lablels: Aa an Idantlcal rrlatrls Is oblained lar standards and analysis aemplcs,.8 1s easy Ib arrlve al lbe eonconlrallwis oP.yuo ele•menls In'Ihe Inillally damp material Eydelerminingme fe• doction fu the weight alter ashing lar each caso. Seven eollahaatoa .rudied e rpeetf,e rnerhod. . fa, the deraminariomelphoephoru4 usina en amhu.uow.fol6.vd hyaridimelricrirrrtiee of O.e h,droniunm lone paduerd by the nreeirvlr•. slaw. of tamh.nunr Pkeaeh.o-. 5r.ri.uu! n..lu-. atien of ihcdm. (or 29.dev.min.rions on trl-phrnylphwnhine aavec Iel11iielv, -aheurn=-056•,., s=0.33„ end . =O.SL. Omhlinp d,e rauhs of ene rolL6orunr tave,, fon 21 determinuion.: = 1L6417e,. I- sheop=-0.157., D=0.18,. and e =0.30. Ewlualion of the daa for 33 Jerem,innion. end:phen>Iphuqd,in'~,c erid o+rr. i v H.11^., !-theary=-0:09%. ,v0.i0; and . - OAS. O.,iuh,a, the •ull. of the .nl- 6hor.tor'meerloned rdeae. fur 25 drre.,ina- Ibne„ Pve: [=13.28^r, l..-thenr.= ' }0.g89e. sa:0:27, and em=0.08:Since rhe eun,ber ofeulluLureron wrs mdll.Ihe.uudr. ' will be continued to aollrrt more drr.. Atomic:Absorption Newsletter July - August 1976, Vol. 15 No.. 4, p. 77 AN ATOMIC ACSOftPTION BIBLfOGRQ:PHY FORJANUARN-JUNE 1975' -. $aLina S(arinand Dianc M1f, Lmnrence'. , , 9'heRerkiie-E7merCorporation ` Nonualk,. Connecticat.061156 The YdBliographyy lialed 4elow9ias Ueen.enmpiledfor the ecnvcniencc o! our. raaders. Copiers o/the arri<ks ore not eoailable./ronlPerAin-Elneer. PerkimF.lmecwill.supplytopieao7'anirles.v.hieh were pufNslmd In the Atomi< Ahrnrprion Nruslrarr;.mld aomb aeks•Iedlsrlida:'from ollYer aourcer.'fn dolrnuinonLirh.r.prlnta are evmilzLle;.plcu!e write uo the Adlwrtiaing Deyarl- laenl, reqYaling Lrochure.AA322, Ticlmiqueald Applicationa of Alomic Ahaqrption.. 00010013 VOLr 6, No', 17, SEPTEMBER 17, 1976 991 s
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A N N 0 U N Ce"'r EN fu E N "I"S MEETINGS ANDCOCI:2SES NATIONAL BLADDER CANCER CDJIFEREPICE The National Rladdar.Cancer Praleel. a granbsupportedlesearch piogram o/ the Division o: Cancer Researchfle::ourc^s arvl Cenlers. National Caucer lustitule, is p:anning to hold an open confclrnr.e or thecti•ao9y, assessmenC arrd".managemant 01 bladder caneen at PdiamiBench. Florida. Irom Plovumo^r 2B IoA=cembm 1, 1976. For, more inlonnntiom, wrilu to Ihe Nahonat. Rludder Cancer Project. St:-V7ncenl - Hespilnl, Worcestar.MassachuseltsOl6f0,orcaal(617)798•6295and.9:royournarne and address. 2ND INTERNATIONAL SYI:RPOSIUM ON CANCER THERAPY BY HYPER• ? THERMIA AND RADIATION - - The 2nd /ntamalional Symposium oaCancnr Therapy by Hypcnhmmia and Radia- ' lii)n will be held Irom Jbnr.2luN, 1977. a[.the Medical Facullyy ol the Gesamlhoch-sphWe ihfsson, Fenerai Republic of Germany. Further.inlonnariomcan be ubinmed from: Professor Dr. C. Slrcller. In5ldul lar Mad Slrahlenphysikund Slydhb:rJiolortie, Universilat6klinikum Essen. Hu/elandslr: 55'. D-i7Essen 1, Federal Republic of Gcr- many. The registration feeis DMI100 or ils equi4alenfin American doAars.and.is due by May 1, 1977. TRANSLATIONS RECEIVED Fachliche Ntitteilungen.der Austria Tahal.ccv,erke A. G. Vol. 16, 1975, pp. 307-317 Gern?an Klus, H. k Kuhn, 11. INVESTIGATIONS CONCERNING. THE NON-VOLATILEI N-NITROSAMINES OF TOBACCO ALICIu.OIDS 00010027 10 05' VOL, 17, SEYTr:r.-vrR 17. 1976 ,
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w A . Dat: c1 requ.et: CoL-Nu I LIBRARY LORILLARD RESEARCH CENTER P03 21688 GREENSBORO„ NC', 27420 For uenl Amhor(ur psdodicd fit)e. .oL and year) Slalua Dept_ REQUEST TiOa(withaulhordpcqealorpariod[cal'nrtddes)I(Incli.aditionplaceSdate). E]TISs.diliomonly VariLd in (nesnurc. nlrdereacs) .. If nen•dreulaling. p)sase sapplYLJlfdcroGlmaHord copy i('cost does noPaxceed 5 Dab~.af revasl: Cull-Ntc LIERARY LORILLARD RESEARCH CENTER PO'3 21588 GREENS--ORO;NC' 27420 For usa. o/~~ Dept. lwfinr (or padedL-el fitlc: r1 or3 7sm)~. . ~ A I REQUEST t Lile (mith cuttor & paqes icr paricdca:.orlidss)(ImL.editica• p(ace 6 dcte). a Tlcs.edifion cnly, Yerified in (or sourco oliderenc.) 8mn•dicu:ntinq..p:.as. cupply El4Ei'°L°' [:]Hnrd cepy i/coat doe. not axcoed S' Date.e{re seL Call-ao LiBRARY LORILLARD RESEARCH CENTER POS 215E8 I GRE'cNSBORO- NC 27420 For rur.n('. AW6ot~~(ar p.nadic~l ti11s: eoL.and'~year)~ Status Dept. REQUEST 77tle (nflb nnlLnr.S paq.s Im p•riodica{ mtid.s) (1nd• edaien. place ddate), El This edition only Va.iAad in ,ar seuree ol' n:. nncel l "- '- '- ~ eDHurd copy 11'cosl do.s nol ascaad S VOLr 6,N©1 17, SEPTEMBER 17, 1976 .
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SPECIAL FEATURES`' . TECHNOLOGY a declaration by dle.ineentnr (or.inventors),drasvings (whennercasa:n•Landlafilingfee. ' Thc lint part dtscribcs.the invention in as,tnnch de•rail ass possible, explainingg exactly what tbc.immnmr, claims.as.his invarttion. The usual practice is to nlakce up a rouuh draft for the inventor's approval: the final' draft may be.completed only after several conferencass between theinventorand attorney. Ofios;. espcciallj'whcn a dsctnical inventionis in- s-olvcd,. tbc altornev will suGRtss additional expt•ris mentsm support the invcrstion. Such.cxpcrimentatian. Is generally advisable if time and: the laboratory budecC permit iu dnattnrney ssill nsake Ihis..suggestium.bw eause he knwn thoinscntion will havrto be"sold' tooneonmore emaminm in the US. Patenl bllice. When the applicalion is readyy fur subnsission,.it is signed by the invemoqpr, invrmlax. and sentrto thc.. U.S. Cetent Oflice,.alonif.vithtlle reqoired tilingiec. The I'amnt Office nutilitss the attomes'.y o0the date the . application u'as received and the seriall numberi as ' signed to it. Eventually, .the.applicatione ssqll reach a,pavent ex, aminrr for his action. The inventor can usually rxpccrlo wait.about a year brSu¢ hearing.g anythinr, funher about his application. -Ate delay dcpendss on baa- many applicatiunxarc ahead of his, and on Ihe cx:un, iner's work sohedule. There is little the in.'cntur can do to speed things up. Conciitein- thrcxaminer 11'hen the eaamincr fmally gets to.the iinrontor'^ ap- plicAiun, he.w'ill ftnt dutannine what kind of inremion is.bcin¢ elaimed. 13e Ihen makcs a search, in his calemm sive patent files. for patents, Iwth U.S. and lirreiqn. dsxn mav sbuw the inccntion urdescribe swaelhing similar to.it. Bwxd omthis eeani.,the exansincr pra:pares a let- ter, an ••o/fitt+action,•• which tclls the ilrccnuor's.attor- nry whetht-r or nofanyoflbt• claims to thrinccntion are.p tentabluwnd, if non the reswrs for rujcctiost'...\n office zctinn that rejrcts.daims also includncopics uff the patent rcfereneess tls:nt thee esansincr considcn to. ahmv nn antic.ipate the invcntion. Sonstimts the cxsuninsr will!find a prior patenD that deseribcs dw.pmpa•d iuvcntion, •vids no resuns for dis• agreemrnt. \Iuss rejictions; huu'eeer..am.based un z tonsparison of thc inv.miun wirb ono.nr morc patrnts tlwt appear tv show.somc similLrip'..Tllr Is:stcorOllice raquirn.tlun.an invention nmstJbc nesv, ur novel, and as.uds not be appa¢nt tn'bnc ofurdinaq•..skill in dKe an.•' l-hce pnccdure rrmgniecs mosn for ar4umrnt here, . so dm.patvnnauun,ey i..allnard thsrc nsnuths uo re- -spond m.thr.examinrr andll•ive rca.nns'svhp heslsotda tecoori8cf bic:seliun, nd allusv the" elaimt.uf ds zppli- eatian.:lt this.pninn snwsl attumeys svill shatv thres, aminer's'•anind' to tho iis-entnr and evt Ilis.idaas alsut dle kind nf ntpomrtu makr. \1'hnher rizims ..huuld Iie ncam¢rd w strupprd from IhaallPlicrtiun.arr mn:dlr...bav: ud sri t IH bc, iuvcn mr. AlKrlhe n)put1SC II:F.IKCtI r-nl tu thc p:urut.Offiee, snxr,d.mrmsbA m:qt Pas.. Iaibre thc rznminor : fin.d .ts,- cisluu..l)e<pito-th<. auurney's arnsnmntx, tha rnaminer may still judyc the invwstiun usspsscnusblc-md make a. WOLr 6, N0, 1']o SEPTEMBER 17, 1976 final rejectiomof the claims. This isn't nettssarilv the.. . rnd, Imwever„ht'cause theesaminerr,decision can I.eappealsd. -fhispoxibility'calls.frir another'eonference'r between invenmr and a ttorrsev. H'hnlicr an appeal will'l be made will depend on anumhcr of factors, such as..an estimam of the value of the invention, and tlsn strength of the exansincr'sarqu-s mnus aqainsrganting the palant. Itccausc the apFx•nll proccdure consom<s a lul of an assornry's time, whetherr furtlicr action will bee taken usually depends ashisdccision. ' \1-hcndliingii go righf ' - fd.the inventor has'..staned with n good idca, backed it up. witharnrkable results :nld pros'idbsi thee patentt at-, lurnc, with cnougls iisformatiun fur a salisfactory..pm- t•nty appli<atinn;,thc cbanocsars• that. after some arSu- mettl, a patcnt « amincr will allosv tcasunable elaims.s for dlc in.rnuun. l\'ith tbitaniolt, the patrnt will be issued snme nsvnths. letcr and thc incentor tiill have aa pumntcd imcntinn to his crcdit. \Inst inccnton frcl'a grcus sutisGctinn in knus.ing Iltat lhvirr ideas., were ronsideredlwunhtchilr, not anlv br thcrosclrrs but hv nthcrs s.buurc likdr m betnmr, critie2l than the)'. l'his is tspeciodly su if the:im•entor has m6n an a<sice part inssrcring nct idmIbtous•,b compassy channrl., and dbnnt;llshc h+.lrnt Olhceq.to a sucrcoLd cnn¢Ivnion. fhcrc is liulc doubt that iisvcn- linns ul tnnmurnlal c:dur rnhaurc tbo rcputatiun uf au inceiimr within his oreanizalion asd br!p ereatua fa- svontile almoyihere Ibr retnrvnilion anrl promution: U'Ires ,sbuut dic incrnsum s.bu.c.idraducsn'cmnAc it? Tbis,is a diacuurl,•inc rspvsiruce, buounc di.nt all per- snns.witb ideas musrbcg prcp.ucd m fxo: Idras umeebr '•eold'tnathrrs, anA a iJr:vlhaPi,u'rn.cll ihoueht nul Rnd elrarli-cRprrurd ..wi 1 hace nmd, dratre uf suo cesc. prw iitcauious Ikcnusr sucer•.ful'. wi:lluut plrmy of h:ud ..ork, amplvd'd sish fruntrntiim.s and discoor- xGfnlcnts.alonq Ihc svav. In holps m be lucky., Lut prr- s"axznm countsJur a.lnr ldca. nre srimulating tltinLs. References 1. BudL..R.A.,'Idr.:, Ib.rnu.n,.WPatrnn."f..l,n \\:4r fr G... Nrv.1'mt,15v >•~.n...r and ran, slnn „ui ' x1.nLe« s. Titc aurlhor' . 00009989 to..]e.n+lru9: 0
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. a A NN 0 U N C E. NIECE N I S MEETINGS AND COURSES FIRST INTERNATIONAL CONGRESS ON TOXICOLOGY The Firs0lntornalional Congress on Toxicoloqy will be held at the Royal York Hotel in Toronlb.Onlario; Canada. Irom Marr.h 971o.Aprd 2, 1977. Anyone interested nlay attend. The.prr.hm.inary IiiH'.of topics':includes: Slatus and Pipblems.in Toxicctogy - (Food: Drugs: Air and SNatr.r; Occupation); In1er>per.ies High-Duse Low-Dose Exlrap• olations (Rationale lor Higb Dose. Exposurnsi Human Correlations. Animal Dose Response: Conslderation of Expenmenla Thresholds:'.Acute Aclions and.. tdeoha. nisms. Chronic Actions aA Moohani;ms. The Low IneMCnce. R.•sponse)p, Linking Experimental Toxicology and Epidemiology (Druys; Conlmceptrve Mormones. Neuro- Ioxicdies, Anticpileplics. Tricyclic Anti-Depressant:;,EnwronmenP Industrial Expo• sures.Imlustrial Careinogens. Food); Toxicology inTrraition (Scicntllic Inftuences; ' Regulatory.and'Public InfWences: Impact om,Dnigs, Focdn. Environment). Papers lor Ihis meeting maybe.submitted bymernbers ol any'recognlzad soeiety or association olAoxicolbgy. Pcrsons:not members ol'such societies maypresent papers . at this roceling il..theyare sponsored by a membenol alrecognrzed.group. Abstracts should be submitted to the secrelaryno later lhanOctober 1. 1976, Program; accommodalions. and registralion information lor. the meeting wil!'l be sonl lo all lhose.whorequest' it. All requeslstorinformation should be:direcled to Dr. Robert G. Burfortl. Secrelary. ICT. c/o G. D: Searle B.Co.ol Canada..Ltd.. 400 Iroquois.Shorb. Road, Dakcillc, Ontario, Canada. LGH 1 MS. BREAST CANCER: AREPORTTO THE PROFESSION, 1976 A conference on "Drenst Cancer: A.Report to the Profession. 1976" will be hel.i on November7.2 and':7. 1976, aPILC Washmgton f hllon Hotel. Washinglon. D. C. Theeon/erenveis sponwretloy Ihc hhiteHouse and lhu Nalional Cancer Instilutc and.ir. 6uppotled'.eath Iwrt/s rc5ulling homilhe sale p1PrRSnlenl Ford's Inauguml Idedalsantl f lates.The ubjective.olphe progravniis 1o.report.and discuss malor problems concerning biology, epidemiolony. d,agnosis, and tro; lnlenCUl breast cancertoday. The.conlnrence:rs openYn all nmmbrrs al Ihe mcomal and healtbprnlessinnand to the p4bI/L.Adv,lneeb rAm:V}han ISqequeSled: there. is no re9iarannn fee. For tllrlhef( infmmahon wrdc to Ms. SAIy Simpson. Oreasl Canecr Conference. 1501 Wilson , Boulevard. Sixth Plbor~ /u7inglon. Vugirna 22209. i VoL, 6, ~do, 17, SEPTEMBER 17,' 1~76 00010026
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ABSTRACTS ABBTRACTS 85t4381iY Ecological studies on burlky tobacco in Japan and, Korea. Iil.. Growth, pattern: yield and qualityof burley tobaceos grown at five locations in 1974. lTakahashi, Yoshihiro; Tsuzaki. Kazuo; Suzuki- '1•oshimitsu; Suzuki, ~TomSko;KiWno, Hiroshi; Oshima, E+ji (Morioka Tub. Exp. Stn„ Morinka;. Japan).l3ull: A/armka Tob. Ezp. Stn. (lforioka Tubako Sh,ikenjoHokoka): 1976', 11, 83-98 (Japan). ` Two burley tohacco.varieties 13urleyand. Ky 10 were grown ar 5 hxations,.Mnrioka and Okavama. Japan, and Bucheon. l'easan, and.leonju: Korca.and vivld, quality, and.smoke characteristics , werestudied. Plant height, no. ofleaves, and dry wt. increased '` rapidly in, theearly stage of growth and the period from setting to flowering at Yeasan and Jeonju. The shortest plant.height andi the lowest dry wt. were obsd at Okayama because of the retardedplmtt growtiv.. There was no significant difference between locations im the no. of total leaves per plant. Ky 10 followed later than Burley 211 by 2 days at the. 5 locations. ' The learshape index of Ky ID nt the flovcrinj stage w•as~larger than that.of Burdey'21 at.all locations. Accumulation patterns of N. PxOs, and'. KvU~ iit the plnnts were similar tno thnse ofdrv matter it:eachvariety at.:resp: Incation. At the Ilow'erlne.stage. P_OS.mtd I:eOwere highest in the piantsgrown at..leonlu and Morioka. Noo differences were obsd. in.chem. content.s of: cured •' leaves between the varieties. N contents of leaves prcduced in Korea were high at'.any xtaikpusition. Middleand lower, leaves ' produced'at Okayamaa were characteriiedd by high alkaloid wnte•nts. The,crudeasheuntenl nflower leavea was hi„besl.at 1Noriuka. There: were no significant local dil"ferencesinl(te total vtdatilc 11.7,e contenc Curedd leaf yieldss of Ky 10 weree higher -than those of Burley 21 nt all. locations. Av. yieldss of both vnrielies were highest at Okaymmt and loweslt at Yeasan, Oiffirrencesinieaf qualitv'arre smalll hetweenn varieties and large iktxven Incatiniis Hurlev 21 was generally superinrto Ky l0:in smoking quality; nlthuuph some charocleristicc differences were obdd. among the Incutiims. . 85: 13839c Treatment of'.tobaeco.with.ascorbic acid. Mewens, William J.; Newmark, Harold L. (Hnfimann. La Roehe,. Inc.) U.S: 3,9581580 (Cl. 131-17R;.A24BI5/'0Y). 25 May1976i Appl: 442.990, 15 Feb 1974;, 6 pp. NOrj intobaccon smoke was ef6cientlp removed by hringingtheg smoke into contact with uncombusted tobaccotreated with a salt.of:ascorbie.or erthorhic acid or mixts. of such. salts and ecid5. Thus. tobacco removed from com. prepd. cigarettes w•as.spraced with an aq. solm.mntg. 75 mg/ml of an equimoL.mixt: of ascorhicacid and Na ascorbate to 15% of the tobacco dry wt. The treatedd tobacco wasdried and rolled.intotigarettes (7 em.lenKth. 0.83 g.tobaccn/ciRarette). Smoke from cigarettes thuss treated had reduced levels of nitrogen oxide. . • .. 85r4t900s Increased life span and'' dccreascdd weight. in hamsters exposcd', to cinarce, smoke: LO'ehner, Altied P.; Olsont Richard J.; Busch, Buhert H. (llinL Dep.. Battelle Pac. Northwest l.ab.., Rirh!and• Wash.). Arch. 6ncirnn. Health 1976,.31(O); 1ui-53 (Eng): Fi4e-gruupsuf.51 2-munah-ol&male Syrian golden hamsters reecivrd! .:1 Iil-min expu.ure+ to cigaret smoke/tlaY5 dity.(week• for th¢duration uftheir9iirs: 7lhree af the ;ruup>werealso chronii•.:d!vexpu.ed to ucruadsof chrvsutile [12001, :9-5] asbestos. CuO, and NiO, resp: 'flieJth group received 1'-.wreklv injections nP 0.2:i mc of diethvlnifrusamine (S,i-1R'-5], 'I•he smeke-exposedd groups livnd significantly. (P < .01) Innger than, their siutm-exp,tsed cnhnrtas and' untreatedd eontrnls. Their mcan budy wts: were significantl7° (P<.0U lower than the shanrezposed groups.. Oeiuvedoneet of amvluidosisand lower budv wt:.in the smoke-exposed hamsterss may have bren rn<ponsibletiv t.heir increased liilr spans. l.'ii;.uct amoke apparentlyattected the immune svstem of the ammals, resultim; iis retardatiunof amvluidosis,a trequena'cause of death ih, hamsters. VOLr Gy N0r 17, SEPTEMBER 17, . 1976 85:41647q Induction of.aryl hydroearbom hydroxylase in rodent lung by cigarete smoke:Apotential. short-term bioassay: Akin, Frank Ja Benner, Juhn.F. (Richard B, Russell Agric: Res. Cent., ARS, Athens. Ga.):. Tozicnl. Appf. Pharmacaf. 1976, 36(^_L, 331-7 (Eng):. Arvl hcdrncearban bydrozvlase (AHH) [9087-52-9] activitywasincreased several fold inn the lungs of hamxters;. mtceand raLC.aOer inhalation of cigaret smoke. Hamsters hzd low hasal artivityof lung A}IH but showed thegreatest.inducibility. Inducibilitywas luwerr but the actual levels of enzyme activity, both basal and indnced, were higher immiceand highest inrats: 14ithin a relativelynarrow ranGe, AHH activity iurreased with.h thee na o0 ciparetssmnked. Iin tests with std. reference cigarets and 3com..brands..ciearets w•hichduiisered highlevels oftotalparticulate matter (TP\II in the amokeinduced AIiH.in lungto lhe highestdcgree; measures which reduced the TPM:. primaril-vfilteringmethods,v reduced the enzyme-inducing effect.. Also:, withregard'.h to filtering methods, the type of cigarets which have Ireen.reported to cause the most extenxive dama,e to the respirator,v tract'of animals in chronic inhalation studieseaused the greatest'enzyme induction itrn acute expts:. Assay results can be obtained rapidlyt max. inductiomoccurs.withinK 24' hr aftersmnke.exposure. Apparently. AHH assay mayaidlinthe measurement of cigaret toxicity. - 85: 53837a Filtering device for a.a smoking' product. Brit- ish-American Tabacco Co. Ltd.. Brit. 1,428,018'. (CL A2:.Ci, i? Mar 1976, US AppL.336,247, 27 Feb1973i 99 pp. The tobacco filter, whiehincreased hss efficienev as the smoke progressed, contained al', least one channeCl leadingfrom thee tobacco section to.a poinr.alonr,the.fi.lter. The wal!S of.this channel gradually became clogged up during.smuking forcing,more.and otore of the smoke to pass through thefull.lengthe of the filter. F g., a filter of ccllulose.acetate tibers (1.6 denier per fiber and 27a)00'.denier per filter) with~a chamtelsize of 19. Stubs gauge increased its fiitering.efficienc-virom38'.to 71% as the smoke progressed.. -85: 4.1R38bTobaceo product containing thermally geHablko polysaccharidcs o0 the d-1,3-gluean type:. \laeda,. Kazuo7 Noquchi, Katuichi; i(awabata..Itlaeuo: Sato. Shi>:e.htkn:Sato, Yukio (Japan Tobaeco.nnd Salt Public Corp.; Takeda Chemical Industries, Ltd.). Ccr. Often. 2,53-"11a2 (CI. A24B15/001, 22 Apr 1976, Japan: APpI. 74/{20,189, 17 OcG 197.1; 53 pp.. Polysaccharides of the 1i-1,3-glucan.type: such as those from Afcaligenes, iaecafis var my:oKenrs 10C3K or Atrobacti•rium rodiobacter, or certain mutants thereof, are useful in tobacco smoking Products. Amis., of palysaccharides. as percentage of final product were 0-1-10,.0.5-15, and 1-30, for improvement, resp. nf smoking, phvs., and bindingproperties. Wet strength and liz0-repe!lent effects imparted by I were amongadvanlages noted. . W. A..l'eabody t 8.5: 42251t Studies on the adsorption.of nicotine on.kaolioites. Singhall. J. P.; Sinch: fi. P. (Fac. Eng; •1'echnol:, Ali •arh. Mnslim Univ., Ali;arh; India). JnilSci. Pfnnt Nutr. (To~yo). 1976, .2(11', 35-41 (Eng). The interaction, of nicotine (I). (53':-11-51 with acid- and'base-sattl: kaolinites resulted' in ealiort-dl•pendentt adsorption, Adsorption, in exeess' ofBEC (base exchanee cnpacity), and the results uflmtentinntetrie and cnnductcvnetrie tiiras.,. pointed tuo init:ial prutonalion of the I mol. w,th acid-s:,nl. Ganhnitrv [Clts-7l-Z[ fuphwedd by interaction with the lirunsted and. Lewisacid sues, Adsurptian in the nse of the base-satd. kanliniicswm due to.an iil(eraclian withithe cnnrdinated water around the capunsand the weakly acidic hydiuxyls m tlVt• edges. X-ravdatmconfinned interaction nt thee edges mtd external besal surfaces with no intercalalion intoo knolinites:.. 00009990
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/ YYrr~V / a l~AV ' V ABSTRACTS 85: 4096Gf Iteproductive toxicological studies with. Hpra=lropium bromide. NiKnruhulze, A.; Palmer. A'. K. (Abt. Exp:, Pathul. "I'uxikui., Pa. C. H. Rochringer5uhn; tngrlhrim, Cer.).Arznrim,-FOrsc•h: 1976:. "-HNSAJ,9S9-92 (Cer)•. The bronchos= wrc«pu.er- .. arCC«PLeara« . 1 . pasmnlylicc drugiprnfnrpium b}omide(I) . [22:S5d-28-6]wasdevuid of teralogenicity following administratiomeithernrally or by inhalatirm toprcgnant rnL+, mice; mtd rabbits;In ral!s,, extremelyhigh I dusescnu>ed maternal deaths ItIN)0'mp/kl;l'and!a wl. dccreau• ul'the fetmta nt buth (5(R): mg/kg). Nucvldhnce of imlmirmun( offcrtililr or perinatal surviv:dl duee tu I was fLuud; and prstnutal develnWnent.prua:eded normally. 85i /67S5h. N-Amidoethyll piperaziees. Regnier,Cilbert;. Canevari,. Roger tScience Union et Cie.-Societe Francaisede Recherche Medicale) Can. 995,683'. (Cl. 260-262): 16 Mar 1976, Appl. 155,103; 27Oct1972;11 pp.. Piperazinea I(R.a acav«cyurrr(. Nsl. substituted phen'l., 2-antino-5-pyridyl, 3-amino-6-pyridazinyl, 2-amino-5-pyrimtdrnyl, 2-amino-irpyrazinyl;' Rt' = 2-pyridyl, 2-methory-6-pyridyl, 2-methYl-6-pyridyl, 4-methyl-2-pyridyl, 4-pyridyl, 2-pyrimidinyl„ 2-pvrazinyl) (25 compds.)' were prepd. b,vy an•lating, the aminoethvlploerazmes. 11 have broncholytic, antianaphvlactic• gastrie.secretion-inhiuiting,.and central nervous - . system depressant properties (no data). 85:,45107f Changes in sensory value by iinteractionn of alkanuls with aminu acids and proteins. Pukorny, J.;'. Ngu~•cn Thien Luun: linndr:ucnkn. S. S.: .lanicek, C. (Dep. b'aud Chrm., htsl. l:hem. Terilnul., I'regue, Czcch.). Nahnmg' 1976, 2l)(3).267 72' (Eng). rllkan:ds involvcd'in rancid fhrvorof fat'-tbinF. foods were stored in. ntixts; n•ith, casein or (ysine(5G-87-i] impreznatcdeellulhse. The intensity of odorr due to alknnals derrenveed with.increusing.lime of storage. itesults of sensory tests did nutt deprnd' on the mnl. mnss of aldcitiyde. . The w•ater content alfectcd the sensnrpy evtdw•ttinn only slightly. The . farmaliun of aldali:~aun:r pnKluctaor polymers and of gluey' flavor compds:.mndiGo-d!the character of the tl::vnrand conl'u+edd less rxpericnred judp;cs• :Dutlt the binding,of alknnals and the nidnliratiun reartinn, were enhanced hy the presence of primary nminn groups. 85: I0R3dm. Development af new thcophylline derivatives: SchlaKer. Ludwig H. (Fharmak,d. Untersuchungsges. m:b.H.. Austria). l6rFeb. Gr/nnrder;rr i'nrsrhunpxpraj:. dfrd. Plrarm. Rerrich, /nfnrmatinnstng: Forsrliua~u(nrrdPrtmc.a%nnd.r, Qrlccrbl: lpirlscli:, Fth'1953'. t8'^-ll IGcrL Fi,r..chum_storrdcrungslbnds Cewerbl. 14irtsch.:. Vienna, Austria. fiistheophyllfne cumpds. (1) 0 0 Iw«- «arutcHr«ac«rc«e« I , ixi~ w 1 were prnprkediw•hich had rnrnnnrv vasodilaain aclmn.similnr to that nravu mp!•c/(inr (317.31 U]. hut't hrun h, dd,lin~,activity was 1U fold: greater nnd' lhe I~ ISpr rnmpds, had Irule uttoct nn heart rate. cnnlrm•tiirn..nr 02 rrquiremenls. Alipltnur grmlpsat. It. had Inliceficrt nn, setmlv:: tlther rum.pdx. cunt;;: 2 lhaebrornirnl or 2 Ihenplp-I:invl crr•uns.ur I,rhvobr,.minyl and I'. 1lieuphvlliin'i. «rpd. by°symmctrirur. usylnrtric.:dkylnmine bridgee were nlvr.prapusedTur pltarmncul: lesting. . VOLt 6, NOt 17, SEPTEMBER 17, 1976 85t 41386d Effects of prostaglindinEi administrred& by aerosol in obstructive dvsventilatorysyndromcs. 1)nnner•.C. F.; Galante, M1.; Andina, A. (Univ. Pavia. Pavin. ISalyl_ C. lraL Afat:. Tororc 1974, 28(6)• _":+5-7, 259•fil. 261i-9. 271-7 . (Itall:Asingle inhalation of prunraglnrrdin Et (f): [743-65-3] t w .fn .. ~. . 1 ~ 0 aerosol had a brnnchr«lilntor actioa in persons with t7rstructive bronchiaU syntlromcshut nal inn nnrnml prrsun.. Trrinmenl' of chrnnic bronchial asthma pntients,wilh.f nern.ul for 2::tweeks impruvedirespiraturvp:unmelcn ln.an extent nl lunstlt•rqunl lu thacubtained with std. mniasthma drugs: Nu.side elfrets'nl".any kind wereseenin thepatientsnr tht•uurmal:persuns e:ptxed:lu Iaerosol., 85:4arG84x Mass speetronn•try o6 hetorocyclie compounds. IX. Stepwisee retro I,S-dipohtr cyclouddition induced by electron impact on 3,5-diplleny:l-I•.;4-oxndiazule.. Selva. Antonio;. Trnldi, Pietro; %erilli, Luigi 4:; [lalin• Ginn C. (Ist. Chim., Politec. Milnn,.. Milan. Italy). Urp:. Afn.rs Sperrrum. 197ti, 11(2). 217-tu (kfiG). . The principal electron-impuct-induced cleavngeof the title compd. is a rutro. 1•8i<lipnfar cyclnnddng giving an ion at m/e. Il9• currespundingto ICrHeNl11•'. •fhisiun ul formed in 2 steps, iinnlvinS clcavnpeof' theC-Ohnndto givoan acyclic mol. ion fullowed by cleavage of the C'-3-N-d bond. 4.19/Rz Nutural protein sweeteners. IRescnrch at the Philip l.yla ltracur•.It Latmr•ttory'I• IligkinLrLL:un, .1. 1). (i'lrilip l.yle Ites. I„x6., 'Catc am:L)ic Iad., i2cading, EngIJ. .Chem: Ind.' (Lnndnn) 't07G, (6), 2G?-3' (Eng):. A reviesv with 6rcfs.of natural prutein sweetenersc evp. thoseobtained from thee serendipity berrY mtd' from. kntvude. - . 65:43217y Studyof 9TSV'reconstitution products by the agnrose go] chromatographyh mrthod. Grama, U. P.; Oleshchen!cn: L. T.; Shved. A. U. (Inst. Slikrobiul. Virnsnl.• Kirv, USSRI.Aff/trnbiof. 7.h: (4ico) 1'.976, 36(3)', 338-42 (@uc). Amethod iss described fnrr fractionnting the reconstitution prntiucts of ;obaccn ma;aic virusGfMt:VTs by'chronrntogy on.2f/e agntose columns:. li.yuse of this procedure, complbtelv recnnstituted. T\tV pnr6ic!es~ were eluted in an early peak• tbllnwedb_v the elution nt' rncompletely' reconstituLed prodncts in a2nd peak. The described methodlproduced resultsessentially the same~as.thosri obtained by hvdrnxylapatite.chromatog. 6.5: 37099v Dentifrice containincd encapsulated flavorinp. Grirnm. Jblm 1?., IIf. LCbl~'alc-L'ahnnhveCa.l~ U..S. .M1,957;961 tCl. d2a-10; XOIK7/IGI,i:f 11av 1976. Appl.'a5:I11Sd,. 15 hfar 1972;9 pp. l.)i•nlH6icrs cnnic;.euo:,y;.ulalotl IlnvnnnC material which is m:intuin,•d srp. trum tSe d••utilrire durih:; storage but is released intu it byy hrctkm¢the rr.c.:irsulxtiiq: >L•e.lls whemthe dcntifricee is used werc ropurted. E.g., 2.S p:ut. micrn,:np.ules eonlg. :107n sp¢armint Iluvuling, 10% Na sacch:vin• 27 green eolorant, and 10% Na /lunroph nphatc (7f11 9T *] were degassed r.nd hlended with a di•nlal rrenmcunt4 tlyt,nit 7, 70'.lc eql sorhil,d I'I11, Nn ~.nch uinAl.l, pn~•rvalivc //.:i, \.i t.\I'rclluln e 1'.0, wnlrr ^-1/.2„ lrt.•:rNa pynoph„•ph:lte 0.6• diC:n phuxphale 38.0•.C'aC'O', 1020. 2T7 nq.,Na N-launndsnrensine suln; 9.5,.and epeorminn thtvur 1/3 parts. •fhr re.ullnnt dentitrire was packed in tuhrs aud upon use rele.urs adistrncta frrsh spanrmint fragrance, flatnq nnd,cnlur. 00009994 972'
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ABS"TRACTS ABSTRACTS ]41Y19, hl:rilm:m. R..11.: Fsdharni: A.P::Itakcr• R: C:: I{txlpa•m• li.IMp.l:nromol tinrthFaralina 4:ne Umr:. Raki}h.SC 27hbU. C'jluuhrunx• p-Klldilfirrnceaprctru: elfrvt of rhemiral Mrnrlnre.on I.Ir. 11 aM'clru in uxrtr•e In•lul(c micmvmrea. I>nry .1lrrnh: IFy.r!•iri•nv Z(3C 3U1- 311a; 197J'.. M3 rdi:rvu~.[•1 A euntprehensis c andy.af Ilm relaliem.hiphetwern ehemical'..Vruclure and binding xas mxdk uaing hepulic , nti,mwmes frnm inlneef male mice. CSltw'hrnme Ii.d3f/ differonce sprnra wvrc dctemincJ spraupholunkrui- eally bu Ril•ewnyl bnuarJC: amitnde.:nuf ulxnrt hMl nthcr srompounds. N'ith suF)niluled pyridincs:. nlrthyl„ car- buqd, ur N-uside subaituenlxan rar buns 2:rnJ G tenJcd to inhibit.or :rlxtli.h apccu'aI hirsJing. who.as auhclilu- liims at <arbon.3151 ur 4 hadi nu uch cOYa.. Asimilar patlern• relative to suric hindrance; wasobscrved~with'tAe nnnmamalic •gcllc aminn: Conformxtion ohangsa.ap- pe:ly d t•rrR,rel the Jil fc•rrntes in binJingoh.eracJ' with indulr and inJolinc anJ with py'r.olc anJ 3-pyr iidinc indulinc F:Iv,: u slrong.lypc.Ip.apaclrunl• nhcrc:n indble pave a ly.pe I vpeclruml. R'ilh the N-nn^Ibyl umidca.- the anl:dlcr wbailmionau'wc type Ilzpa'Ir:r. amLn Ihc +izc ' of Ilre acyl.mui¢ly imrc:acJ uhrxthat of Ihc acclanridye. bindingwas dimini.hW;'fht mnnoalk)I:unines payc.dis- IiO[I typell stsCtr:l, hut uaSlcriC access9o Itlf nitruy,t0 was ninderal. type 11 binding tt as srbuli.MeJ m Aindel ed. Slm resWts wilh various mtriles, phenntr, thioryanalls, and phenyl isnlhincyanateauRaesled the inlpnrlance of tLe..eleclroniestate of 1he.nitroFen for the ahility ofthe eampound to cause a lype II spectral.ailift'. It is likely ~ that the criteria'.eslahlished'..for the nitrngenconlaining compounds may also appfy la othar nuclcopliJic alams. American Industrial,Hygiene Association Journal .August 1976,. Vol. 37 No. 8, p. 464 DECISION AND ESTIMATION PROCEDURES FOR AIR CONTAMINANTS' Bar-Shalom, Y. et al This paper discusses thcproblem nfenfhrcing stand:[rds nfavcragr expnsurc In alnltnplinric cuntaminanls in :rn indmlriaP crts'irunnun[ AA decision is lu he trfitaincd uilclher'Ihe aclual level of eontnmireml is :dwec: nr bcWrv the slanJarJ.'ILese Iwu.sirualiunc.cnrresp•.nd,.re- spcairelp, tu stxlc5.uf "k•ompliancc" or'Virrla- lloti' Nith reflMrt lo Ihc.sl:uhlard. .1f1cYTltese stanJards were prontnlr:rled.l is vec IvaliarJ that [hcy sbuldd nul.be crdorcnl in n.Wa.4:.and- N'fiile m:mnrrr dur.lue dioinha•rcnl voriahililicss irb.nhc cnvirnnmcnl a, ucll'..:rs.in.litc nrcesure•Itlenls.°A 'Ihis ICJ to Illc iilvoaligatiun rrporleJinJs froln tdlich Iht nlain rrsull.c arc przanrted ficre. Ullirr slali.q::cd :mpucls..nf aii polGuiun havc rrecnlly recci.rd a great dt•ol of atlcn- lioll.tr VOL. 6, No, 17, SEPTEMBER 17, 1976 Tobacco International August 20, 1976 Vol. 178, No. 17', p. 52 . INFLUENCE OF MANAGEMENT'SYSTEMS CULTUVARS, AND PLANTING DATES ON FLUE-CURED TOBACCO PRODUCTION: II. CHEMICAL CHARACTERS. Gooden, D. T. et al TMe aReclf o0 diEerent manap•emenfsystemson Vualily.of flue- . eured 1MUcio: (Nieotiare labacurn l.) w aate•mmeE. Systems emGluycd cooxisLrl of convenllmnnl loYYinq heignC af IB leaves Nrvested s a.f18:61 or three (18/31 times and twu syslenrs in which planls were.loppedat 15ieaves.a,rd nzrvesled.twice..(15/2) . a lopped at 12 leaves and harvested mm lime.(12) 11. In each of the syst¢ms. Constant IeahpCpulaYon per heclere s w,ma.ntainedby mod/ncxbun ef planl pnpplauoo. 0addNbn, 1zand Ibrcal' - syslems lalsu barveslcE ene and Iwe lim.+s: respeclivelyl were. included with 10`, increase iwleaf population and in N fertiliaa- - tion,(12r1f11 andYt5/2101. Tlra.eMeets ol lewer narv^sts ar Iobauo Vaelitv were evalualed hem mEasuTmenls of total nitrot'•en, total a141oiE5.,m'd rrdue-Ing suP.ari try.stalk position aM'..by composilce leaf 0os,hons and Rre ritiof o/ sugLr.tU niASoCen..nilrogento i1kalTdl and wg3r ta aValpid. Totlncco tcppedial 12leaytl and harvnstlE onre had smstan- tlnnf• ni,^,ner lotrl alkaloiJt, sligb'!y higner. totali nltroreni, and Iawer rwducing soPars tban toWaccu cunentlonullytopuedand nar.esteJ. nlsa. rr.!los of.suRarlo nit,oCen. nlhapen to slgaluial, and surar to alkaleia were IOeMr: The'/nCreattd Ilal no:uLlr.4l and'.N lertillcer oEthe 12and 111eaf syaltms reaulted In lower sugar Ievcls:. vmen har.rosti were rQduCEd. mnLCans.ol wid2ly ddtcrGnt ehnm- ia1 and pnysiczl nrpneniet werem acd tapotne.. Tne enernisby by btalk p4LY.on z)taualely describ05 Ihis tubacu. InlcrmN-alc syslems sual• as tne 15:1/.) ar.E 1613 arc work. aNe aomprnm,sraI bcrauseyieldanU m.ali!p Ws di•evinedprcrviously: 9) n e xuptatle andt/le rrqsK.J Lre enemical aCer-- aliens are not as great as with IIM 1R11 systerni. Journal of the American Oil Chemists Society August 1976, Vol. 53 No. 8, p. 545 MONTE CARLO TECII'NIQUE' TO SIMULATE AFLATOSIN TESTING PROGRAMS FOR PEANUTS Whitaker, T. B. et al. ABSTRACT A compuler rnodel that acrountc for 5atn1`IinR, subcanrplinC, and au.d1'tiral culabth[y a.as drvelnluJ 1. sinml.lc ull:rtnxm Iestm6.l•r•'flurers. \lunte C'arloo solutimr li:cbniqoe: svvc cml'lo)a,! la.acmun[ for eonditinnali prub.rbillties tUa[ arstc Iroln vrulttpb+ samples, subsuoRh•s,, and/ur anelvses bcmc tued in lestinC prnfnlus. Ihe.allmo_clu rhslmghrol!ramto be used'.an lln•. 1074 pealut crop was.evalnatud by Ir¢e of.l7re dcvaibcd modcL s QQ01oQ0p
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f ABSTRACI S ABSTRACTS ~ 85: 41951j The effects of smoking on myocardial conduetion~ In thehuman heart.. 13ckheit, Suad; Fletcher, Evan (Heafth Sci: Cent., Univ.'I'exn. Ilouston: 'l'ex.). Aat. Hear[J. 1976• 91(6), 712-20 (Eng). Inhalationn of cigaret smoke immediately' ~/' LJ 1 inereased theatriuventricularnodal conduction velocitiv, shortened Uieeffeetive.refractnnPcrirak and'increaxaf theventrictdur rate inatriahfibrillirtihn. 1'bese elTeotswue attributed toadrenerRic slFmulntiun produced by the minute amts. of nicotine (1)[54-11-5] absorbed. 1'absurpiiumduringsmukingwas confirmed 6y incceasetl urinnry f excretien. Smnking unlagunized lhe eho)incrgieeffcetol'dia;oxin [20tit0nnthe:nlriuventricular - nalul emtdumveloeity, anda8uhshedthe R'enckehach hibek: whether it occurred spontaneuusly ur was'induced by atrial pacing. It didnnt.atfect.cenduc0on velucitx m the His-Purkinjesystem or in the anumaluus pathways.in the 1VO111-Parkinson-White syndrome. 85::43240a Somee aspeetss concernin£.g the identificationn bythin layer chromatograpltyand thee diicct determrnatioa insitmofsome.natural p-pyridinic compounds detected with, the Dragendorff reagenG 13aiule.scu. George:E.; Constantlnescu• Titus (Rom.):. Reu. Citim. (Sucharest) 1975. 26(11), 952-8' (Rom). Nicotine (11., cainine. (11):, anabasine(111), nornicutinc (IV):, nicotine oxide.IV). and.nicotihe dioxide (VI) were sepd: by ascending thin-layer chromatog. on Silica gel GFaw by usingPtrhle-h1exCO-\7eOH-25`7 NHa (4:4.5:1;(1.5).. TheRr valueswere 0.146! 0:527, 0,36,. 0.22, 0.054, and0, resp.. Tlie spots were visualized under uv light (254mm).4 following theapplkation of Dragendodf'sreagent. Direct densitometric.detn. (t5`7 error) wnsw possible for l, lf and V.. Thc method coufd,beapplied'tolhe detn. of 1-Vf in tobacco products. . 85: 415351, linfluence of taste-modifierson taste responses. of pygmy goats.. hlehren. M. J.:Church, D..C. (Dep. Anim. Sci., Oregon State Univ., Corvallis. Oreg.): Anim. Prod. 1976. 22,. Pt.. 2. 255-6D (Eng). Addn. of gymnemioacid', f11(!IJ99-64-0]. (20-100 ppm), to 25 % sucrose soln., caused pygmy goats to shawstrnng preference responses. Addmof'~ I to a, tltl`k suerose.snln, did.nnt change the response from, strong rejection: Addn. of I to.1000 ppm quinine-HCI did not change the strong rejection respnnse,.whereas addn. of 10-100 ppm 1:I to a 200 ppm qtrinine stdn: changed the response{rnm rejection to nonndiscriminaGon or weakpreferenre. Addn. of inn,cinicc acid III): (1a1 J9-7] tosucrose soln. did.nott chan„ethe respnn.e frorn nundiscriminauon: 11 added to quinine saln. changed the reslnmsefrom nondiscrinrination toreji•ction: Addn. of munosodiurn.;tntamate (142-47-2) to. sucrose and quinine sulns. pmduced' varinhlechanges in thee responses, mwlcrate preference to.nondiscnminaliun or rejection to nondiscrimination. 85: 4045Uh, Analysis for volstilce orknnicc compounds at traceleselse by gas ehrunurtographv. %Lnk.is•.Alhert U. S. Pat. AppL 450,5114 12 Mar 19'1~IL Appl. iSU.:dGIL 12IIUnr. 1974: 44 pp:. F'nr thr qua;. nnd :pr:mt.,cas chcnmatun. anal. for a:obrtiic org. compdv,...the volatiles are rnllrned ande.nri6hedmn a sun,ple trap cunte. Tenax GC adsurbcu[.. 'I'heI trap is inrnrpuratcd'uttu the chrnmatun. iitjrcthr Iaut srt tlmt the org. vnlatdes dusvrtlmd from the udsurbant' are iulectrd dfrectly into a ervu¢rmc V etnlunm lh prnvi,le a sharply'dldined pbm, 11>r ;ns ehrornatug. r thee chrnmatup. anal:, the roliunn wav a Ni cnpil!:rry etched with na dil. IfNUi-HOXc m,In.. prinr tn coating with the liq. phase, e.g. Enmlphur-U: The sopg. elaiciency ut the Ni column was about twicethut.af atainic>.: steel. eolimma. 'I'he uptb was used fur anal. ul' uriitc anntplcs, frurn nnrmal und diabetic humans, far anal, uf hummn brr:ath•,for air nnnl., and lur anal. for S volati4s tiurn cigarette smoke,. eolieei andurinc ut a human with cirrhosis. . VOLt Go NOt 17, SEPTEMBER 17, 1976 i i 85: 45181f Compositions for replacement off smoking, offoodk. Kolta,. Rezso:. Cseko, Istvan: bfihalszky,. Karol,v(1Cozmetikai esHaztartaxvegyiparil Vallalat) ]lung.. Teljcs. 11,131 (Ch A233), 28 Feb 1976. Appl. 2,697,. 20 Jam 1975[ 15. Pp., Stable title compns..contg: polycychc arom hydrocarbons in - owconcn eg.3,4-benzop?'rene (50-32-8J<01 f;2,5,ti-dibenz=anthracene (53-7.0-31 <t).005: 1;1-benzanthrnern¢ (56-55'-3]. <0.5, 1.12, bcnzprrylene [1'91-2-1-21 <0.3;,andrhnsenc [218-01F9] <0.005 ppm, weree prepd. from Beech tar by distn. in vacun,, treatment of the appropriate fractions with 3,20 wt.r7a:charcoal' or mincral adsorhentspretreated, with 1-5 we. % paraffin., fractionation by distn.• and adsorption omw a carrier, such asNaCI, glucose, starch, edible oil, etc. These:compns,,,added at5-80. mg/kg food give smoked flavor and taste to fonds and also stabilize them. Thus, a homogenized mist. of solid paraffin1, charcoal 20, and petroleum ether 25 g was allou•ed todry, the product homogenized with 10 g charcoal, and theproduct'homogenized with 300 g beech tar Iraction btu 80-120°. The mixtl, was held 5 hrr at'0" and filteredl and the prorluct; (270 g). " distd. After a prerun (30 g),. the fraction broT. hluhoais homogenized with 50. parts NaCl. 85: 45092c Synthesis and flavor evaluation of somealkyl= thiophenes. Volatile components'.of anion. Galetto, William G.; Ifoffman, Patrick G. (lies. D<v. Lab.. \1iCormi<k and Cu., Inc., Hunt Valley, h7d.). J: ARric: Food Chenr. 1976, 24(4), 852-4.. (Eng).. 2,4- [638-00-61. 2,5- (638-02-8], And t . 3,4-dimethylthiopFene (I). [692-15-5]. prepd. and evaluated organolepticallq, did nutt contribute to the flacor offried onion when examd. alone, in combinath,n. or when added to artificial or natural'l union oils These fir,diuFSarea contrary to those previouslyrepooted iitn the.literature:?-1)ethc!- (5;>1-ht-3) and 3-methy(lhiophene [616-IA-J], and 2'3-dimrti:ydtfriup/rene '[632-16-6]"i were als'o: purified mtd evaluated organoleptically.. 85: 44344z F.vidence for tlie: proximity of sweet and bitterreceptorr sites.. fSirch, G,. G.; \t;i,acannm.. A. Hs tNatl. Clrlt.. Food 'I'cchnol.. Univ. Ncadinu. SVevhridge. Engl.).. Naturq'(London)~ 1976', 260(555'26 632-4' (Eng). The bitterness nr sweetness respnnse of panelists toSle u-trmannopyranoside(1) soln.. was reduced: , by presatmi w•inh 50% sucrose or 0.0048% quinine sulfute,.resp, in contrast. taste respunse to sucrose wass nat', affectcd by presatn: w•ith, . quinine.sulfate and vice versa. This.loweringnt the.gustatory responses to 1 suggeststhat at' least.sameoi the sweet and bitter receplor sites are within 3-4 A of one another•.and.that.presatn, impairs polarization of I by chelation to reeeptorsitesr s 85: 40129h Scudics'on thce quanlitative dcterminalionn of pyridine in coal tars. 1. '1'he alkulinehydrolysise of the products of the reactions of sonrv chloronitrocornpounds witlt pyaidinc:. Xoliwski, Itumvcdd;. Zakrzew+ka. Ewa: 7bnmsik.. Piotr (Inst. Yrad. Deterrninuoinn. .Aend. 1?con.• Puznan, Pul.). Cherrr, Arm!. (St'nr.wnrl 197f,:, 21111•.i3-tla (I•ingl., '1'hc reaction of 2.A-10iN1:Cr.H iCL witli ppridineyielding 2,4-dinitrobenzeae= pyridinium rhluride'e tll'. 1%inrke"s rcactionl was used fur qpant. deln. of' mixts. ut prndiue base<. I was hcdrolyznl in,0.l.lf aq. NnOll givimC2:4-IU,NI:C,:IL\lIClll'lIClLt'ItC11U (11)• w'hichh in turn slowly decumPd: yieldine HUCH:CHCk(.:t':IICHU Iilll. Thee detn. isbnscd nn mrasurema•uts nC thre sum of' thee absurhnnees of the deervnsiirr, haud uf' 11I1y,900 nm'1)and. increasing band of III ('_'7.i:0b <nr0.. I,ean be replnced'~ by2-chluru-5-nitropyridine. The methud can be usedd for detg:. pyridine, 4-picaline: and nicutine. A. Janowski 00009992' 970
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, SPFCIAL FF,41 I~RFS~; TECHNOLOGY if, after stnh a srsseninK/ Ahc.idrn ssill Inuks svssd. thce ntxt stcp.is tn arrnqgc fur one or sonre pmotical tests. Evcrynnr.avishrxprriencc knuwr. that.astidra ntayiaok.y wonderful on pa(terburr fail mix•rably sshtan actually tastcd, cither as a chemical experiment in the I:dmra- tntyy or as a mechanictl impmsestsetn.in a pmrluetion nuchine The U.S Patent OIGcr knows this :md eon- sidFrs an invention to lae made in.nvn xmsti.'fhe Fast Aage is a mrnnd onc, thc.Wca or `ins.entisrcuncept." 'fhe secnnd isplysic:d, the «ssing of the connpt.or ^the ndhctionto practiceP Fnran invntlion invnlving chrm'itn', the.n•duction m practisx mua consist of at Ica't one acutal expcri- ment that demotsstrato, the sun•essful application of the inventivc cwnttpc For a mcchanic:tlinccntiun, this isprcferablv accomplishs,d.lsc actuallyy incurlwratin¢ theconacpt intua madsinu or mechanical proass. If the.invcntion relates tolargc. expcnsive cquipmcntt dsat is unacailablefr exlxrimesnation. a pntentt appli- wtitW may bes.rittesr tufullydcsaribe the invenris'c wncopL and be considered a"constructivorcductiun td ' practice.^ Complete and accnmte.records of expes'imenud srork at this atacc xreM viml 1 bttause tesl.maullsnlieolurm the h:asis of pru4's'ms n4nsrts for higher man:sgcutent's cra1- u:rlion. prnpcr dating and w iutcssing am, of coursc, as . esvntial hcre as for the original idea. rUicrsuccessful.tcstingr When the cnnccpnt and cxperimentalresults are.de-grilxd-either in a teehnical publirzrimr ar a patcntt applivation-thc actual incrntor, or inrcmurs. mue[ be clradyy determined. Namcz.uthcr than thoso of the in-orntoss may erecp into tcehnicallpapers, and can eause. a p:ncnrtober incffcn ivc. st is sunumary fnrr the rnRineer's c.nopnvtu mvicw a draft of a tccbniad palx•r, or patcnt:applintion priur tn Ilseir.ubmissiun to umsidc.ayn'ncics. In urmc osrs,, the invanriun mar be anssidcmd mnro s•almsblc as atradc seerrl and itsipublicity furbiddcn. fhis; u1 honrsc• is tukinga chance, IaxausethVe ie little protection iff sa:recy is lost. Usually, the incvntochas a.;ood wm'kinerelation, ship svish.htssupc,isor.md am dixvxssviilt hitn idv:.ss devololxd that Ise ferla havre pmmi.e and should be fnnhcn It hrlps if ihc wpvn'iauris:uuirnus. d thridca whrn it was lirat asnerivsd and tcrortlLds bis fasns-.shlce opi6iuu isufien cswtsti:d f eita funhcndcrrlhpmcnt. If apptvcal is,t.'r'.uved and the exprrimrntaI u'ork is Gtvorabk, the invcutiunis rcady fur>ubmissiun to pal, cn...pcrsonncl. , Ofeourx, thv arqxrvirur may rcjmttbe idrz nnd'dis cunrar:e fmrbrr .IrveL,pnscut. Incrnmrs. hnvr bern knnwn tu cnahr:ul aud uruk.uut tltrii' idra+ without. nplrcucal. 1'hisix.t b:v:uduu.rundatakinl•il thr idta dse«i t ttork: and mac hces•rn nurco vr if iodn.s,~ ,1nv+ nnr suhcadatunl• will hnrr tuJrrdup hin.utvn r.sctios fur handlinl;snch s uut.uinn. Startin~,fbrntal proccrlures. A stsnnd.trd diie:losure fnnn is usus114preserilxd, on u9tids the inventar tli.uribcs his invcn6ve cnnrept and his devdopmrn Wnsu Its in dcudl. Rrcnrds are panin ularly impnrtant nrnv,.(unning the basix lor disrlumre- and thc palcnr applicatiun; srhkh nsay, follow. 7he completed distiosure is.then,wnt.tu thepntrnt depan- mcnb.'l'Im ihventor should kcrepa cupgof the diselo- sure f r hisliles• nntingg thedate of sohmi<+inn. l le will probabh' h:n•c to follou'.up.sviihinamonrh urso mx< vhnt actiomis Iring taken. ' Kiu•n thcpatentalcparuncnt receives a diselusure: it tasuallp aasiqns a file numhcr(or rucmd and givadte dix'luzurc. too oncof thc astorncrrt for rc.icsc Thcrc is apt to be sotne tiine lust here;&causr the aunmey may havc.a numhcr nf othcr disclosures awaiting his atten- tion• as well as other legal chores. In a siwation of'this son• the auurncv usuallv fa.rors the inrcntiun disclnsuros that cantait. the must infor- mation and artihe mnst ele:trlv wriiten.'fhesr arethe casiest to undrrstand and taev:duate lor possiblc pat- ont protcction.:\Lthis point, dte inceuturr is again sell- inghisidea„this'aimornthepan•nrauurnt•y. hfnn patcnt:utnrneyahavcteclnsicalbackqroundsin additiun to legal vaiuing• and :ux capable of asking qocstiuns that ntay nutharc ocuurred iutba insrntnr. Sonsninsrs, xn in.cntor nctr nor bc sure ,rhat.his in- vcntion rsallk is: and tbr, suurnr" will halp Sint clarify his tllinkinV and puintt out .rays in whith the iiss-entive cunccpt could be impivvrd. :ldditiunal cxpamimenml work m:n, be fnund nav san' m dclinitclrrstablish wnrkabiliu.'Phc ihrrmnr is rreardcd as cspart enough in his lieldto have amnidrrcd aotrtechnical advanccs that mieht bc rcLncd tuiiisiitvcntiun. Thusr shotdd be includcd in Iils iitscntiun diulusum and disotnsrd svith ahc pate nt atturncv. if thc techniual literoturc has Ixen shown to nut hasx anticipatcd the idLa, the auurncy will mually.tnakr.a prdhnin:uy srareh intllc patnn liirr.ttuir for petenn dsat m:n' ahxady cunmin tho pmpoudl invc.ntiun.nr snmathin4'similnrto it. f)n the basis nf the literannr suarch-.the.auorn.•v considcas the ndvisabilitynf prc- paringa patlnt.lplillCatum mld notilhs.the iureuturaf his decisian. If.tln• da•ision Is unGVrnrahlr, the auom,v ss•ill gi.'c his rc mns and incitr, the insvrnmr•s cumturnrs..lf dre incrntor stilll fni..Itis. invrulive concept has utcrit• lie shuuld dizans it fiuthcr tvidrthrauotnce.:\ dilfcrcnt approach ml thernnccpt rould result in. a suwantial insprnvcmenL ' Filiisg the patent . If the incomi.x emmopt appra rs to.he p.nrntable„tbe attorucv scill prrparc and lilo an applir,uiuu.:\'uaPpli. catiuu:rousi+ts u/' luur purts: u spccdiradm ..ith.daims, 00009988 a VOL. 6, MOt 17, SEPTEMBER 17., 1976 966
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4 ABSE RAM.:3 ABSTRACTS 85:4:i178k Swecteningcompnsition., -Shoaf. 1\lyrnn D.; Pisthke tl ah/imle. U. ft.encral Faxle. ChrWIr95} ~ 03 ~ Dec (CI. 426-J6; A231.1/236).11 Mav107G,. Apph'li-0 1973; 5pp. L-A+pnrtyl-t.-plton;t•lnlani,nr mrthcl rrter (e11'M) [22839-47-01mnv be used in heverage mixes nndotherdryiuod applirations by enenpsalation hy meltinK in a fusnbio mass and grinding. Phuss equrd x•ts, nfi nnhvd. ritrir'ocid (77-92-9) and trtriracid monoh)¢•'rate (i94J-29-f] are blended, the blend is mixed tvitlr an equal wt: of APMI and passed lhrnu;;h.a No. 8 (U.S.1 screen ontno a double drumdrit•r heated with steam at. .. 22-8 psi so that theairiemp: above lhe rolls is 116-22"F. The distance between the drums is 0A08 in.. the 1-ft-diam..drums. being operatedd at. ^•1 rpm. The material isfused completelywithminy brouningand. max:, fusion att the. scraper found at26psi~. ateam and ].20° F air temp. Chemass is ground,, andd thee particles (120-40 mesh) dis.vdved in,4i° F'water in 30-5sec: 85:.42220g Tobacco budwurm.. Parental and inherited sterility induced', by reserpine andd gammaa irradiation. Guerra, A+ A;. Garcia, R. D:. (Cottom Insects Res. Lab:, ARS„ Rrownsville, Tex:).J. Econ: Entomol., 1976, 69(3). 339-12'. (Eng). Malepupaeof Helmthia uireseens rearedon diets contg.. 0.1% (wt.tvol!) reserprne[5P-55-51 and then exposed to 15 or. 20 krad ot gammairradn..a all substerile.deses forr the strain,, gavee rise to Pi males that.transmitted delayed sterilityy to their Ft and Frr progeny. This delayed sterility had its grea.est expression in. theFt female prrgeny. trtadn: of the male pupae with]0. 15,.^-0 or 25 krad adversely affected the emergence of Fi females,.and the:greater the duse, the fewer females were produced: Oviposition, egg fertility, and the no. of Ft progenyproduced.per female were. not.dcpendentt om mali ng. f requency.. . 85:14251c. Treitmcnt of vinyl chloride. Kngira.'fsutomu;. Takemoto, Katsum Japan. Kokai 76 3L675 (CI. BO1J,.('06F.. AOIN),. 17. Mar 1976, Appl: 74 105,794, 12 Sep 1974: 3 pp.. PVC (9002-86-2] or a vinvllchlnride (l) copnlymer was used as. e. carrier for p3'rrthrin (111' [121-29-9) and parnthinn (I11) [EG-38-2] to prep. insecticides. Thus, a.spray contg- a.1I-111 mixt. 12, petroleum compds. 88. propane 26.4,.butaneri4:3, 1:1 Freon, hl-Freon 12'18.6: and 1:1G.g wros irradialed weth 1~-ray at. 0:11 Mrad/hr for 100 hr and mixed! (10 g)) with.100.gkernsine. and 20 parts Triclrneto prep. an insecticide. 85:42014t Oxamyl-troated soil protects tobacco against black slnnk k1i11hq.F. M.;, McInt\rc John L. ICnnneeticut Arric. Exp Jtn.,. New )Lavcn, (.imn 1 1 httupnrhnlqey 1976; GG(2), ?-1 4 16nLOrnmrl (I) [!313u _!-tl) at rates ar5.58: 11.16. and 22.32 kg/haa w'asapplled tu lirld plntanf sandy Iiram: pH 5.5. in \1ay. Shil samlrlesweret nmured fu the greenhouse at 30-dayinlervuls nrern 4-mnntll periud. planted, wilh. (oharcu lVindsnrShadc 117 (\1'S 117). andimxvlalyd II weekIalrr with^•104 zoaspnres, of a CnnnecLient isulatc ol' f'hvtuphthurn paraxilira rrieolmnm'. Seedlingsnf \1'til I I i lubaccu transplantediotn sails.Ihat.won•. tn•att•d tqr tu9tl davsearlil•rwith21.:12 kg. 1/ha did. not develop black shanksvmptnmsk while Illlli kgfhn gnve intermcdiareprutectiun :end G.:Hkg/It:r aftlnrdedmr prntectinn over Ihistimes perund. Oreenhou.e studir.r indir:uedthat a 2wcek,periial was required, ntlersuit'wax.lre:nrd willt I before scedlings :tre prute•rted against tht• palhupen. 7•ubavt•n seedlinfls gruwn tip lu 21', . tlavsin I Ireawd suiland Ilicm lmrrsplnnlyd imulnuntrc.tr•d snilifnr I wcak.priortu iiuwedeliua develnped LLwk .hanks~nipt.,mr: In vitru studie•z.howed that I cmtcns, as hildh asIIaLeKJmI 1= SJ8.0!f klah:d are nul tuu^iriil:d or inhibitun'. tn xuuvlmr:m;fin prudn. l'rntrdiuni a4ainw binck. slinnk isprububly due to I brrakdown prexluotst VOL. 6, NO't 17, SEPTEMBER 17, 1976 85:J5196p Cerealswenteniitp. Hap;erly,PatriciaA. (General Foods Corp.) UtS. 3.955.000 (CL 42G-96:A'l:dL111Gd), 04 May 1976,. Appl. 508,295 '23 Sep 1974; 4 pp. Sweetening of breakfast cercalswith artificial sweeteners, such os r.-aspnrf)1-= . L-phenclafaninemethy/ ester (APM) (228:19-47-01, has been difficull because theintense sweeteners nndthalow snly. tend'to give pinpnintburningsensationsintioentoutke fhisdi.ad.mntage can be overcume by applying the aPM in a starch. hydtolyzate with. Ibww dextmse equiv;. lU.li. <3W: Thus.9.65 e, hydrolyzed - ceroal solidk (82 % hexasacchnride nnd above. U. E. lti-1:i) v:as hotnogenized with 14 g He0 at 110°1' and 1Atg A'\tl', rwuled! to 72° F and sprayed on 444.5 g cnrn fiakes. The coated cereallwas dried'at 180° Ffnr"-5 min to -2.5% moisture. 'I'he sweetener coating was^•0.24'"k b,v wt: The cereal had asmouth sweeteness similar tu.that of a sucrose-coated.corn>fl7aked but did not have the overlyV frosty appearance assucd. with thee latter. The I producl was staLlefor at.least 3 monthsof storage at high.and lowhumiditiesy f85:46890y Beezylchrysaathemates: Aries, Robert Fr. Demaade 2.271,196 (CI C07C, A01iN), 12 Dec 1975, Appli 74 17,103, 16 May1974; 12 pp. The ester II was prepd: byy treating . ... ty . er et W s°'cx , . ..wtosaa_1>_ tn ehr)•santhemoylI chloride withCsCI'sCHiOH in thepresencee of base. 85:AI8G1e fnr+estigations on the acute.toxic effect of pyrethrunr on. various'hematoingicnt aspectss of Meriones hnrrianae..lordon„thr.indi:m di+sert.gerbil. Knreh.A. K;.. Saxena, S.. C. (DeP. 'Lbul., Univ. liaioschan,. Jaipur, India)., Pyrelhrum.Post 1975, 1•J(2), 61-7 (Bug). Indian desert gerbilss . treated with various acute dbsess of py,rethrum (J003-31'-7j, showed aa significane decreasee in hematoccrit„ red binodcorpuscled counts, and maen corpuscular volume inlheir blood. A generail decrease in mean corpuscular ll.b) andmean eorpuscular Hbconcn: was alsoo recerded, butt was significant only with highereoncnsr of.insecticide. These effects were revcrsible,.and the parameters returned to normal within 488 daysafter treatmenL 85: 42139n 1!'ffccY of piclornnu on the phenvlntnnine am= monrn I\n'c: activity of Nic trtmr tahnumrn ittdtmed'by rcaction to the tohucomu.,tit vrrus. I'n)n t M.; Vrdlee, J. C.; AlrrWt.,C.: Vwu\t.(.p Irtvlle..F. (tita..'hyslupaLhol. Veg., Inst. Nhtl. Re•ch. Agrun., Uijon•. Fr.). Yht4nrh:•rnistrvI976, 15(5),.6G9-il ,(F.r). an ,Nicotinnn tn8acum var• \anlhi m~ ~xI_ ~oorx - xa pAenytntaninr nmmonio. Hmse (PAL) (9021-^-B-G], aclivity,, which incrt•nses siFniGcanth•tturingN lhaJeypcrst•mitivity reaction tu Rdmecu mnaaicvirus ('1'\I1'). wa, onl_vparti:dlvV al'fected when planla wt•re lreatrd with prrfurum (11 (I91S-tr_-Il..whieh is knawn to he an inhihitur nl 141Linvi4o. IlsingI'tu;;otben witli'1'SIV, wns pe,sible to dislingui>h hvtwreu Ihnt incrraxein. PAIL acttvitv dtte to the. virus and Iliat de)x•udenOnn thephutoperiud., 00009996 974
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1), ! °' C~a °°'M {`~ ABSTRACTS 85:4G9alr Imparting a coumarin-likearomn and flavor to tobacco, foods, and drinks:. Takahara, I{rrovau; Morlshita,, leao; Sbrga, Mtkm. L'Lhtlima, 9oshikatsu. (lapan Cohacco and . Salt Public Corp ; Fult' I lavar Co., Ltd.) G S 3 9 LA;670(CI. . 4:G-538; A23L). 16 Alar 19:G, Japan: Appl 73 41,344, 13 Apr. 1973; 10 pp•lndanone I (R = H, kr =\ic R2 -4,-SIeO, Rs = pr r nr' 1 -.7-A•icO), useful ascoumarinOavor in tobacco and'food: wasprepds by a Friedel--CraRs reaction ofcrntonoyl chlnride.withe p-(h7eOlzCrHr and cycliiation of the prnduct. Alko prepd. was I .- (R'= H, Itt= M'c RE =4-,`•!e, R? =' 7'-a1c0). Similar. I]avorir,g'g praperties were given for the.foiiowicc I, whicitare new but not prepd. hercin (R; lit, l:r; Ra given) Sle, H. k R? = &6-OCHcO;, Me, H, 4-A7e0. 7-hfeO7 Me; H. 7-HO;,H. Me, 4-Me0;. 7-AieOH. Lt, R"Iit =5,6-OCH 0' CH\Ie•e. H 4-Mv, 7-H0; H,. Cllhtea 4 Ft, 7-HO.Et, H, 4 4ie 7-110; H f1H\le+: 4-MeO,. '7-HO;.H, Me. R^10 =5;6-OCH-O. Known I(R= H,.Rt='rfc;, Rr = 4-Ma;. Rs = 7-"de: R= H; R~t= blh. Rr = 4-Mr„ Rr =7-HO).were als¢claimed ns.similar.0avorings. 85i 45177j Flnvoringg compositinns'contniaing misttereof 2,2;0-Irima•thyl-l-cycfohexen-I''-plnectnldehyde and 2•6•G'-= lrimebh,rl-l-crotonyl-1,3-cyclohexndiene. Pittel; Alan O.; Klaiher, Erichhl.;: Vnck, Mnnl'red H; Shuaer, 1{divard J.;. Vinnls, lonquin (lnlernatinnalBlnvnrs and Frm,•mncesInc.). U.S. 3,959,5(18 (CI. 42d-5:W;.AY31.1/2hi), 25 IMac 1976, Appl. L07;112, 19 Sep 1974; . 12 pp. AA t?avooingrnmpng consistinl( of mixtures of 2,2,6-trirnrlhyl'-1-eycG•nrxrn-l-yfnc•rtntdrfi}•dc (d~cyclalmmocitnd,.U [13 =25,71.tmd'2.Q.(i.frinrrlY:c(cracnncl-= 1,J-c}r/uhrxudrrne (dmrutscennne, il) [-°.1716-91-Ilis.dosrrihed for fond, tcbacco;, mrdl pcrfurnes. 1s 0.1 pptn and :~. 0.01 pptn Wvre ndded to a raspbcrrp.llavnr (nrrunlnGun with nn tmpr.rsr•mt•nt in tastc andarornn. When I is mldrd at lhe rntc'nf I 11ptn, the addn. uf71 a40.05-I.ppmlgivcs an elfectiveilavor (nrmulhlion. 410.3b IIrtcuninatiun of odor contpunmtls im lobacco. .rttuke- dcxign ofntistrrre to si',nwhrte odor. Ura.nie.ks,.A.;. (/lUhnnell, Anne; Ruihclt, H. (;. Iltes. IneL• Illiunislm.l.. 'I'i,nhnul., Chicngn. IIII). A4ffl(dli '1'rnns: 1975. ri1, 1'k 2;. 12 (1•:ugl: AA tnixl. conlg. 112 rhrnis. was furmnhde,+ tno siwulntn Inbaccu xmolrr udur. 9'he curnponenls rcpre.ettt' thee principal'i sensory and, cltom: clnsses of rxtnrnnts in tobacco smnkr. h'lashvapnrizaliun of 6 dropsL11KM1 lYr rnsulIe.tl in an twlnr t hat tensnn:rhly rrsembles lubncca smnke ndur as jud; cd' by 9 p:ureli::ts. '1'he rulurr i:csprvtod In 7cspund to odor control prorexsrsur Ihr• some wnv as the IuttKCU:sntoke odor. li8:41'B72t; Cunc:mavalin-A aRRiutinalion orhmuan pu{= monansalvcularmat•ruphages I'rmn unn.mukersnnd c.rC:rrettc sruukcrs: acnmparisnn. N:rrr.I;IrnnA.; N1:vtin•.H..Kussell /IDr-p, \led., 11nVrlit-. Cbll. Med.. Hl.ustun, 1:if;^ s:i, 1976, Ii11(U, 1177 `il 11•:ugl.. Incub.rliun of pnlnwnarrah'.a.dur nracruph r e t uum nnmr t lr.•r. in I h.I b:urv bull +,•da.Jlnc II IStiII d 1" tninimd':mn r;lutinntfi n r f Wnt• acll., wih•rarr smuhar',1'AU..mruh.nrd ur Ilril Intdnun mm.nnrd' individhallc dtrprr.rd in nu.prmiun. Incuhatinrt:wilh I,hr• Icrtin runrunnralrrr .4 IVim A7. irldnrui ngeuhi,urlitm nf' 1'aSls Ir ur rr :m-ltr snrr.kr rs• whil 1 A.1a Irum, nun.ut„kcrawr•re nnt Iunhrr:r,;;lutmrlrJ. A.1rr Irypsiir ur.rlrurut, hulhi uunsmukrr : ud nuv.kcr RA.\I.+ .rt ,lul'iu:rlydl in Ihr prr.enat•.' uf l'om A. Ik.th I' A\f p„pnlatinux Il,mud Ihc s;mrr :unl•.r.: Cun. A... Lum Irnqu. 1!IP1. „ rnrrhvinr:u:w:md: prr hxaliun uli. vunkr•r' I'ASI, wllh. )aufar:udehkdi• pmaanl,-d. i'ru ,1iriJurvtl roII rq;aurinaluno ('unJ:dn hr,mul'tn..P:~\1.,hv l.•,m :1 were.imil•:rl,v ei:Mnhutrd r.u.llu~.urlirrr. ul"~nun.urrkrr aud smukcr cclh. 85::37096s (Jxalirianex oxathiolSncsand: tltctrderivatives. R'inter. Alax(I•'innrnlch.J A.) Gcr. Offen r'i3J,1G2 (CI. CO-U, Av3L), 12IFeb 1976, Swtsx' Appl. 106Iq/.741 02Aup - 1974; 47 pp.. 1,3-Oxathl mes; 1a nxathiulanex and lhcie dcrivo• . werepreptle and used to mrnlifv, imirrure,, or increasee the organolcptic propcr4es of teruds, tuheccn Ilruducls• and perfumes. The.compdse could,eitlter be isolated from passion fruit.juice,.or prepd. synthcticsllr. For example, 1;i4 g;f-mrrrnpfnheronol (51755-R3-0] wnv relluxed with 2.2 g.ncatn(dr•hyde [75_07-011, in 20 cros q•dohexaneih thepresence.of p-tuluenesulfonic acidto give 1'.5 g of a 9:1 mixt. of ris-2-me(iryf-•f-propvl-1,J-oratlhiane fl) (59323-76-1] and the trnnr-iaumer [5933.1-17-3]. Two drinks prepd. by dilita of 1 part com. raspberry or black currettt syrup with 4-9' parts HiA were arnmatized by' Ihe addm.i of 0.•50-0.10 ppm 2-melh,vl-4 prupyl-I,B.nxathianc. 'Clie aromatized raspnerrydrink had'~,a fullerq.lreslrrlntal aroma and the blaek currant drink had a fuller, more naturalltoste.than the corresp. non-arnmatixed..drinks. The use of cxxthiane in corn: totnato- juice added a fresh, f ruity. character to the smell. 85:41639p Gas-chromalnFraphic dctermination of neo= phytadic.nc as a nwastrrc of the tcrpenoid contribulionn lo expcrintental, tobacco smnke carsinoger.esis. I:urrin. dl... H.: Olerich, C. (Anal. Chem. 11iv., Oak. Ri<i;;r Vlal. IaU., (lakRid;:e, Tenn.i: F.nciran• tet:. I"J7.i, :U(S), 9G67-7:3 (1':irg:: A gas-liq. chrennnme: mctluxl is drse•ribrd I'ur dcrn. nf n;•,p)rvtndrrrrn (l)'. [I501L9f,-11 inthc total p:rtlicuhur matter ffPMD ol' eig;tret smoke. Ty'pical Jrlicvries,nf 1'.IE-r 7 rip;dre;s, U-Jlfi pgl'dci,;nrat, 0: 0:027e. wt. of 'IP\U are prrsvutcd and comp'ued with thnse. (orr isoprene dorivs:. I is .vn9;;e=ted u. a pre:krrcd :uv.rrune ol' theC contribution uf Ierpeaniilz to cxptl. tuhaccu ~tnnke carcinugenicity: S5: 116.h/g A full)' autnnmte.d nltlavinll•t specu'nphulomctric method. for thc dcterniluation of nicnti.nc alknlnids im tnbaccn0 and tobacco smokr cnndensule Ue Vrirs, A.;, Do 13ocr, M.;. tictlurcr, 1). (U:msre. I':; I,erts It. Tdb. Factories, Joure, Nclh.). Tobarro 175G, l79(JI'. 7d•d1 IF.itld: A fully. automated tnethod.fur the datn. ufhicutiiw alk:daias tntabaccoor tobecco'smnlce condcus:rteo is clescribed. Grnund tibacco or tobeecu smol:ee ennde•nsate can nn ;utalvzed dtreutly using thc. stemn distillutitnt unit dvs.rrbcd, in cunrbinatiun with'a sulidd prep san:pler.. Thc merueud is h.r;ed on the isuiatiun of thoe nicotine atlat!hids 1'rum :ut 7dk'. suspeusiun of tobacco or smokee eondrnsatc hpsleam diaGl!mion. 1'I•.e.perceutacc ofnirotinc [5l-11-5] ia Jerivcrl sl:ectrontclricailpv frmnn the diflerence in ahsorptionnl9.59 nm bel•vren an acid suln, and anetnral anln• olnientine alkalaids. $amples can be prucessed al a rate of 2Ui.hr. y 85:37291h 'CLiucyaua0orhrunriun(Ul) cantplexes'.wilh ni= cotine and lhc analNtical drlrnninatimr of tfiisalkaloid. Gtmc•seu, lun: V;uhe1vi, CashaIU'niv. Crainva, Craiuva. Itom.). Arch. 1'Anrrre. (Iti'rinhrrrrr, t:er.) 1976, 3U9(4)„ 251-7(Ccr). C N Vv t Nicntinr (I) [5t-11 5] reacted ndh Il'i(CrINCSI:;i (nllowrtl'd hv. I~Ii.CI l r( nm.tlm Rrutr,.kos:dt:m:ductiHrllC:di~Ciliptinninrll-HvU. (59.i5a-AY'. ],. '1'hi. .ah. rrnclyd. lurthrr with nminrss tr 'bnn rumplex udls u( Illr hpeamiuc.l I(l'il \C:ti: i(~irntiuell,and'wilhCoP11.11 tmunc.;,hv tu lirnn Jeriv,. ,udt as.trrrn.a-~l'iderhYlenedi=amnt•L( LII('FI~V(•itrlniraliu:al 1 alnn runnled'& with~ I(uue 6..:dn rminr ,ma4•a tu lurm ih• d rumplex saltseuclrnsuu trt•.IIIOaIr\(.Sluaruliretl [.i.:./3'1%'-U Yl. b'a,rmnt'ron, of this snh w;w usod as. IL•e hisfur' pennunµ:utontetttc and epeclrophuluuuqric ntrllhnls Ibr drtn. ul', .1. 00009991 VRI - 5- °.rr,,. 17. Srnrf-cl'r,r-f: 1'' 1q?r . ~~a . .,._.- •. _.
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. ~ ABsTRAc°fs ABSTRACTS 74161341. . Piskluv. V:.P. (A. f. h7ikuy'an AO-Unitm.Sci.-Rc. In.l:.uf TubaccoandlMakhorka Gruwirg,• US.tiRI. Sadeuhnnk u.autkrn tcim'W i pnMuL/us eerr Pirnli/a v dbachnnm d.mt•. I l'amvnf uf rr.iduexaf aiueb and pru- dutts dilspyrul)es in tubacca nmu4. ~ LcurL /bfun mq 1: 35-36; 1974. LRusxiani. Resfdues uf iinch andof prcdui pyrolyais Rsydnraen sulfrJc and carbon df.ullide) :txereaudied in Wbaceu.smoke.. Cigarettas nmdeof tobacco with 6 me1k8 ainch. obtainad frum tuhtccu pksnl. prayvd.with lt.};} liheb suspenairm. and cigaretlcs with arlific:dly increased =ineb residue kvek. wcre: inveatipavH.. Tnebreslduex weri nUl dctCc/esl in the ci(rucllc amuke: Curreklliurl w.rs . established between the zinehresldue kvel inruFaccn and she content of'tiydrogcn sulfidc IU.It47):md c:ubon Jixul-Gde (0.N991contont.in the lobaccu smoke. WhiIC'thecar-bon disulfrde residue ih the smaske orresidce-free toba2ca, wasbeluxs9he Jetecliun limisuf LS pbqL it macheJ 161 p fA , at a zineb residue contenl xd 2.71a µFcigarelte. 7 he hyJ-fo8en sulfrde cuncennation in the smoke was 143 pt"I lot residue•free tobacco. andonly xfif:htly higherf IAB PCI) for Iobaeco w'ilh 2:712 pp otf zincb.The,incrcasc in Ihe.arhum' dis111frde to hydrogen sullide.ralio fmm 0.05 to 0 86 . :w ilh ibereasing zineb reeidue in Ihc.lubaccurfrnm 113 tu^ 71S Nyk cigarette indicutes dmrt cmbun JisulliJe : is furmcdprimarilyal high temperature. Uver I0Sc M the amtitmiarbon disullide that can be thcuraicully furmed IGnm the. ainebresidne i, axumcvl to Fe preacnt in Ihc central srra•am of the smoke. H)•dro8cn %ullide.is.most probably furned frum cunc~m dimlfiJc in tAe presen<e uf xuter at tempcra- - Lures.ahove I50`C.. ° . 7&iR21.. HudBsm. E.; Philpnt. R. M..Qyep. Enlomul.., Nonh Carolina State Univ.. R:rkigh. NC SM71. Inlerae- 11nn of mslhyltnedinsyphrnmi pJ'-4a•naadiuanfaq eom- Paunds w illr tn.ymu und shvirr effn•ts nn mammrla. Omp Me/ub. R,,. ll"-1: 231-301: 1973. ('89 relcrenccs) : ' The interaction o( melhvlenediuxypsern•II IMDPI compounds. wilh micrusumal ervymes and'Jhcir in vivo effasts on mammnlsare revieweJ..C.nnprmnds.of this aruup are.used acinv.adcidcxyn<rpnis. Thc hfDPcorn- puunds:rrr: highly reactive infiiuIus?cal sysGms Jnlcraet- inr with a variily'uf x'n¢yme systems und functioning as buthenzyme inhibitors.mnl inJucera. The imrnctiun of these cumpounds.with cy9oclrrume P-450 hulicen de- mumtralcd in a number uf sfreies. and the el)ecl'.of this inter:wliun. inhihilion u( mix.•al-funclEon mxiJax:aclivity; has been Jemumoral.d in many murc: This rcaaitm is:nW -.compelitive, involving instead the (urmati.m uf,a stable tomplea. lli- apparenl thal whenxsinp nbmc• MDPcom- puunds present litlk.msic haaard', and:ulvcrsc.chrunic effeelx alsuappear to re4uiru high duv~geo. The premesl p.rtFnlial b+/arJ prexentad hy. dic MDI' cnmpqmrWs iv in thi:irr in x:iv.r imeraaliun with othcr xcnuh~oliem MUi' eontpuunds are wid.•.pre:rdlin nature:uN ucenr in a numher of hnman taudnlul6,'IhaMrn<iryd rurnmerciul MUP ccnnlMmnJ piperunyl hula•xiil(•. ia.yuile stable..aL IlhwFh .olicr camrymrvd...uuh n, ryl'er.m:d'.:uc la••v xtu- bk. It icmttluJN rAut the-0ararde pre.anta•J by these compxmnJo-upry.ar al lle rycnvnLlSme w h• potential. rather than pruvcn• Imttheycannol be iymned. VOLa 6, No, 17, SEPTEMBER 17, 1 1 976 761220. Kulkarni'.A..P.:htailman. R. B.:i#akcr. R.C:: ' .Nadg.•qrl. 8:. f Dep. Hntumul.-Nurth Carulina State Vniv:• Raleigh, NC 27607): Cytnchnmrc 1'-JHI dirterrnc<spersra: . type kl inluracdunsin inxetivNe-rdstanl md -suseeplibk.e iuuseflia.DrrrA Mclah• Di.rMrx/riun:A31: 3U9-720t 1974. 448 referencesy fAietusomcs wtte: prcparcd fmm the fresMly-essh -abdomens of 6-dary-tdd . femak hnuse0ics uf inxccticide- resistanl anJl-susccplihle strains. and their difference apectrawere recorded sfectmphntumetrk:dly. The rahs- tionship between tAesespeelra and the chcmical.struofures of !he microxumcswux examinxd fur pipcrunyl; butoxide• amifruls•, xnd more than 100 olhsc. cpmpounds. The pqesenceof a•'sluric:dlyaccessible-• nitrogen atamwithapairofnunlNmdeJcl.amnssvanaccessiMeoxygen atom in certain cnnhpuralions.uppeared to be of primary impouancein.lhe.furmaliun of type i I difference spectra. However. faelnmsuch as xteric hindr:mce and ch•clrunie '_. cunfigrrratinnJelermincd the xPccrral macnimJe• The ab. surpriun maxima;md minimn v:rtieJ xith lhelig:mdanJ the source of cvlnchrurne P-4y11. Allhuu@h thee ra•sryinmv.of the susceptible (S) and rtxisumt ( RI micrus.mex lo varimrs Rgandkwere generally similJr. spectral maeniludas relae live to thr. CO spectrum wcre always smallec in Ihe $-micrusr.mcs.andlAC spectral hhifl asuciztcJ with lypat binding wasahxem (rum 5-micwwmes hut present io. R-mieruenmec. Hurthumnre• cumpuunds.which caused! . type I spcctruur a mixmrc of typc I and II spectra withICmicruxumcs- causcd eilher'a type Il or: nn dctcutahlt spectrum with S-micn:.nmes: anti Ihe slreclral maxima ' and minima... if wtt identical.. were alwzys at a shurtcr wavelengtis in the R-micrusumcs than in the Smicrosumes: - . 7411l2. Thnrutenwn.l. H.:.fkouuFb; ff. W.IDep: En- tumcl:. Univ. Kemuuky: I.oxinelan..KY7/Nlln1. ('hlnri- nalyd Imeclirich, naidws in the Cniser.in, uf Kenluekv eeference.and alkalnid xe.ivxei4arcucs• fiih. a.l: 2q5): 25-28t 1976..423Iri:fcrcnces). P.lectrun uaptnrc F:w uWumaloeraphy wacused to determine.thc chlurinalcJ In droe;nMm in.enicidc.reridl¢ kvds in Ihc rese:uvh:rnd reli-rence vigareu.•% pnrluceJhy Ihe. Uhiversity nP Ka•niucky's Tohaacu anJ Hcalth Ra search Institule:'f.ul:J chlurinaleJ innvcGaide reviJuestnn theeiFara•ucs m:mul:¢IbreJ in PM9.ren}rJ hum12.Stu 61.7 ppmm thv hiplica Icvel% anpuarine. in Ihe I R I reference cigarette. DD'f-1U4: rc.Wncx.aruunteJ ILr mure than 97'k u(rhe Iu1al rc.iduex in thaec eigarv nev: the remainJ.•r eunsialed u( JielJrin and:cndfrn rexidurtv. Nu endi.•allim wasdc4cted.Parlhecig;ucue.m;uudS.wrcJin197J.1he ehlinin:ncJ inwclicidbre.iducs ranFS'J liiml 3:h 10.7•1 ppm: UlyfdUl.i accuunrtJ for 6--77"r ul'tha•.tuuJ und [ndoeulfan a<annnlcd'Jbr Ihc. remaindcr..Ymal.e.condcn- sate derived frum tli< IwA IRI ciy:rt[tIc mtJer .vmJLrd smoking eamdiliun. euul:rincd. an averaF•' !f x.1 pc DIIT. 7 DR revalucJVipnretlC,ApPlosimulcly vl2'.i uf Ihe P,P'- DhT'was Itana11crred inlacl le, the ruzm..nt'am xnWAe. 00010005 983 s
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ABSTRACTS ABSTRACTS Journal of the AOAC July 1976, Vol. 59. No. 4,. p. 894 IUPAC'COMMISSION ON THE DEVELOPMENT; IMPROVEMENT, AND: STANDARDIZATION OF METHODS'OF PESTICIDE RESIDUE'ANALYSI& Slade, P. 1Le eiqhtkmeetinga of'.the ehnve Commisaoe. . of tha:Pestieide Scetinn.of the.Applred Chemu- . try Division of IliPAC wats held at Jeafotpa Hill 14aearch Station, BrackneR; in September 1974, aoder the Chairmanship of'$: Frnhce..The fal- - b.ring stmtawry of the proceedings isbaxdion ' the minutea.of the.meetings and an thereporte prerented byy members and avuciate memben of ' the Cmmisairm as indicated. Thr Commisslne ennaideted the repons of'the PA0/WHO Joint Alecting an Peslieide Residues (J\IPR) held in 1973 and.the meeting of the Codes. Cotomimiun on Prstieida . Residues (CCPR)i held' in 1974 inenfae as they a3ected the Residue Analysis Commission; and arraner meala wxre mark for memberas to cover some of the workconsidered as dcesimble by the meetings. fbmvpropleat flad brenmade dnnag,tbe...pre. . viouayear in preparing the Commissiun e:rmom- mrndatlonc an.an•tl-etical.methoda for publiex• 'tian aa IUPAC Tttbnznl Reparte, end workk on thia woold contioue:.. rt '1. OhtanocNfeeine CnmpoursL The.Commission:discussed recent rork on the multiresidue method recammendedby.the Com• misTion in 1969, Studim have included a enm- yariton with other multiresidue metheds, estrae• tion fram noffand blood, and a rapid method for milk. There has been'importantprogress during the year toward solving the prublem of the aeppratian and estimation of . pnlychlbrin:ted biphenyb (PtRs): Perchlorination'widi anti- many penlacAlbride:Eives the deeaehlorohiphc ny(, which iv apamttd /rmmn thee organorhlnrim insectleidea. Other studier have ineludad',.vrk on eleanupadsurhmis,.clretrolylie conduetivity.de- y fatara; and analysis,of pnlveWorin ted dioxine. Dilhcultlea in.llie use of cntimonypentaehloride for PC& were discussed. Cancer Research September 1976 p. 30!01 A RAPID ASSAY FOR STIMULATION OF HUMAN LYMPHOCYTES BY TUMOR- ASSOCIATED ANTIGENS Roth, J. A. et al Lymphocyte-stimulated pmteinsynlhesis(SPS) in re- ,FponSa to.humamlumor-assUCialed antigCnswas assessed bymeasuring ('M/leucme incorporahnn, Correlation ol SPS with othenin vixo and,imwrro responses:was demonsiratetl .. by immunizing normal fublecls wtlh-keyhole limpett hemp- -, q•anih and tesling seguennally frozen lymphocyles:and se- _ rum samples. Ona week after immunizahon. lymphocytes from normal sublectss demonstrated increased.SPSlo key- hole limpel hemocyanm. This correlaled wnh..lheappear- ance ot delayed cutaneous hypersensthvrly responses and peceded detection of hemaggltumahng amibodiesand m- _ ereases in lymphocyte I-hjnrymidine incorporalion.. There wasnodifference+nthercaclLvity.oflreshar,dwabrelro[en . IymphoeylesL and as few as 5. l0'9ymphocytosimicrolner plalewell could'be usetl. Tmnor-assoculcb antigens were preparetl from four lung carcmomas. six sarcomas. ano srx Inelanomas: using 3. r1 KCI extraction. Lymphocyte re- tpCnses loo both aOtolognus and allJgenem tumor extracts were observed. Five o/ 15 pauents'oemonstrated significant SPS.to aulologous lumor antigens. Fourteen of 20 lungg cancerpalienrs responded to:lbnq canceranligenr wnereas' onty11 o142'..paucnts~wnh other tumors and 3 0119'aormal: subjeCts reactetl.. Signibcantly, more lung cancer pahema' reacted 10 the tumor extractThan to an axlracl nl' uninvolved, lung from the same patiCnl:. Twenty-one..ol <22 melanomapalienls responped tovnelanoma anligenL Ten ot33 patinntss wilhblher lumolsantl 3.of 24 normal sUblects eacted to n12 . melanoma extract. Eight ol 30 melanoma patients reacted to an extract of'muscle fromlhe: same eonor as was the melanoma antigen. Tumor-associated anlyenic acuvny o: 3. - N KCII extracts can thereforee bedelecten by measuring lymphoeyle{1'H)leumne incorporation. Analytical Chemistry September 1976, Vol. 48 g No. 11. p. 1645 INSTRUMENT CALIBRATION FOR THE MASS CHROMATOGRAPIi Lloyd, R. J. et al The mau chrometngrnph (}-31, t dunl eas densily dMttlor ges ehmrnaingraph designed. fln on-the-flymuleeuler weiKht detenninaliuq is hawd on the4undamenLd rnnrrptxnf nu-meruus wnrkers (J J). Snmples aresplitrntu two appmrii mnlclj• rgunl frerlinns Mrr snlatiimwtinn in the iii iertum Inrl„ aretrnpprd un idruticnl trups•und tlmn strnultannerslybark0u.btl,nntolus,rn.Urhrdrulumes,tnodiifl•rcnlcarrier . ge.esLrinR empksyrd.- r OQOiQQ~/ VOLt 6, N0,_.1], $EB7EMBER 171 1976 985 ~
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AEW L! ~ ERt"U'URE BoOK' REVILWS • Polluted air presents a.similarly un- elear piaure:thero: is the signal Ihat the pol)•cydie'c aromatic hydnxaruons gound inIhe tars taken from sity air eause cancer in:animals. Quamitatson is difisult..8ut the anthors of the relevunt aurvcycrosclude that it would bepru- dent to.regnrd the air pollutants-at the level. say.of those mcasored in Ilos M- geles'_Oyears ago-as being equal to the enforccd amnking of aboul haJ a.packof' cigarettes psr day. (Controlshave fmce reduced that figure fortos Angc- '&a.by a faaor of more than 10.). 7:e 32lehapters of.lhis.volume end with Iwoon presensopportursity. bo:h to fearn eauset-with or without the7' mechanisms-and loo esertzonlrol. We plainly necd a slronger shield of preven-e tive medicine, which calls fna m:aythings, from.a wayy of paying ftr.e it to6xing a balance between dtie.pr Ivacy of the individual and the utility ofnation-dly linkcd records. say lor a death in-dea. Ftor• dasa• mose workcrs. moretfuste more remgnilion of'the publlec smifare::cancer begins hcrr to appcu' like a subtle s cial disease. "sVC ue talk- ing about'.peopie andirsos paiealasif wa are tryine to preserve lifo. we should be ]aoking:as peuple before they.are ca-. tienls. Thal is'the essenceofprevcniiverncdicine"-and also the: aim of atxalthy social a:dx: Pollutios, cantroL The fuim,nir.n. n! lbwfnr!em llamuer. (Studie, in [n.irnnm.r.lal I"allution.). 6).1'. J. W. Suunucn..pp. 125. ISISn- . thtsler UniverzilJ-. 1lanchc•,ter, Ayril IHi6.l fe.95. fdwo.c appros.cs of pollution. l.'n- f•utunately• however., its cunlroll is nnt wnplc. i.3reat deal nf crtort and mur.ey may he Ce..'o:ed lo. redusing th:z ammomt of, . erme t: sic suhssance in nor cnvironmmf.., wirh littl.• or no u,<4d ellcet„ hecau.e preliminnrr •mJlae ha•c no1 Mcn madeIn find out what,.if any, harmfnlcReats the suhsunuc is rcallyprvafiming. Our' mumrcmare. elearly inscl6centa too deal with r;,y prnsihle source: of pullution, and'.it ie.WCrefinee„rn(:ull tllat we disNSer whiefi ar Ihe.great-est dane_er, anJ cuncrntr te,.6rv;,on their control. Ih this hwd' 1)r 1'. l. tY. Saunden of Ihe \alural tr.mirnnmeni kcaarch (nunail. and formarh of the I'ntlu- linn kc,ear:h t!nit at \t.rnchesler. Uniser+iss•, sete.ml to how Auw the rcal, h.lrasfnl cnecto of. p~ntlutinomay. he mc,litlMJ..Mrhat r/re:11\< e•lnlml mea,ure.. nuy he pkmncJ: 7 Ae buok 1VOl a6. N0 r 17, SEPTEMBER 'i7, 1976 h primarily intendud.for stndcnts and aJministmtor.cunccrncd with, Ihis suAject• alshougb it can alss he re- commended to the more shulious members.of the: wiJer, public who are often so socal about er.vironmental problems. Dr. Saunders Jtfincs pollutium as rthc intnsduction fiyy man or wassc mtter oesurplns energy into the en- vimnmcnt which directly or indirectly eauses damageto man and his cn- ' yironment.. orhrv than himsclf; his honscholJ, thine in h6 cmplnyment or thosee with% ahom he has a direct trading relationship". I am,unahle to - understunJ'd why sclf-inllictcd, Jom- estic. and tsccupeuional enpmares are excluded eacepl't where they intemct - w•ith mGCr t,pes of pollution. Ir may - he more di0icult to evaluate this'.typc ofdamage in cash terms's but they are equally serious and equally neces- sary to control. The amount of ioformahon con-. dansed into this small hookk iss quile' remarkable. The :hole held off air„ • , n'atir. soil ar.d of :atuaries, and Ihee spmffic prohlems causcd hyy pasisLrnl'i pollutanlss ia fummarlscJ in undcr20pagcs. Global problenrs are dealt with in about the. same space. The re- mainder of the tc.r JcscrilrosIhes many Iechniques in enimat- ing and mcasuring, pollution, with snumbcr or weluclrosen praclicall exampler.. Thc estreme ccrnpre>.,.oni dbes r.nst make fnr r.sy renJin; which may discourege lex•infcrmrdi readcrs. StnJentt who often only.'re-. etiit a superficial iulloductivn to this • . suhserl will benefit must from ih.con-tent. . Kennrds 1leflanby 00010029 1 1007 s
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ABSTRACTS ABSTRACTS 85:4516IzEffwt oftime,.temperature, and reactant.ratio on pyrazinoa formation in modelsystems• SI!ihamotor Takayuki5 Bernhard,. Richard A.. (Dep. Food Sci. Technol., Univ. Cnlifurnia. Davis, Calif.h. J. Afiric. Food Chem. 1976, 24(4), 847-52I (Eng). Faetors.affecting tlle formation of'.pyrazine - pa~~ u.,.' a /. r . . -. oompds:. from a trgfucose ~[50-~99--7] andl NH3 model' system were studied. Changingthe: reactant ratio„ reaction temp., and reaction timeinfluenced' total yield, but not the distribution patternn of the products. Numerouss expts: gave knowledge of optimum yield andnnique distribution of pp'razine compds. such as unsubstituted pvrazine [299 57-9], 2 mrtlYlpyrazine_- [109-05 0] •2,5-dimethylpyrazine [121 9+-0].26-dlmethyl'pyrnzine[[108-50 9J 2-ethylplrazine [1392r 00 3), 2,3 dtmethylpyrazine 5910-R9 4], and.2,d,6-trirnethylpyraztrte (1) [Iit667-55-111. in . reaction mists. 85!42Jfi9s Further studies.omtlie-propertics'of human. ''plaeental miurosomalcytochromc p 4:in:, Zachnriah, Prjpce. K.; Lee. Qwihco- I: Symnls. ftenneth. G.t Ihchau. 61un1, It. '(C+a•h. Med., Univ:.O'ashingtun,. 5emlle.. Wash.). Hiochcm. Phnrrnacut. 1976. •25(7), ifl3-tltN1 IF:n61. Andrustenediune tll bound tn:either 2 sep+cyl.K•hrnn!es nr tm 2.sites un:thes:unel eytuchrnme of human pl.lcental microsomes: One hindingsileg had highafiinitv and low capacity ;ind the nthor had. n lower aftinity hut I!iFher caPacil>:. •1•he ahsorpliun max. N511 nml ufthe cr, cnrnplex uf hAUI'll reducrd plitcental ryluchrame I! 450 (l1)') could be nhulishrdd t•ompleleiy headdns• Of luw eunens, Of 19hvdnxtamdFu..tnnedumo.l9nxrr.!ndroarnedi m u1..('anrt:d.. enpnhh ul LindinKtu plnu•ntal LI ncre;.C•' i 1 or-(' 1S.slcrutds3 witlh strurltrres siinibrc tu. ( ur I'.) nnrnndrnstenediune. C IHS slernidk:vilhstrnnlrrs.iinilar t•.Ihnl uf ,f t•srradtul„ur+!rbsllwres. cnpablc. Of lurmhy;: lvrrihrnmchronres. \Imt al' IF.rsetumpdse wt•ce• nlsu inliibi:ursuf [.iuumal ir.n!iuu. excepd Ibr CO• mrlvrnpunr: and niculiwunide. A rule furplae:ntalII in lhe arnnutliintiuu renctinu rvas implicalyd. 85: a1905x Thcdiffcrenlial effrcts of chemical carcinogens on vilamin AstaUus and on.microsomal dtug metabolism im normal', andivitamin A-deficicntrats.. Hauswirth, Judilh \1•;;Briiuela, Barbnra.S. (Dep. Iried'4 Sinai Hnsp. Baltimore. Inc., Baltimore, Md.). Cancer Res. 1976. 36(6), .1911-6. (Eng): 1 1' =1 r Male Sprngne-nawley'rat weree maintained oni a vitamin A[1f103-57-J)-del'icx•nt diet for u weeks. Althouch serum and [tepat:c.levelsof vitamin Awerc r:nificantlp lower at this tome, no outward signs Of vitamin A def:ci,•.nt•v wrre present. Hepatie microsomal Ievelss wf rvturhrumuf° .1:i0 [9035-51= ( in the vitamim A-deficirnt animal, were 70% tltal' of the cnutrol nnimals Ofl lhea micr sumal cnrvmes studied. rthvlmrmphine N-domeUryln.ce I91Lt. r.%-I); nniline hvtlrurnt.1se [9012-a0-01, andanrfnupvrinr•N-drmr•fMdn.cr [!IIIa7~-GV,a].,mly tl!e.hr+Lane wass adveraelvv afl:•ttird bv v.irnmin A drliuivncy. :)-.Afi•fhtli'hu= fanrhrrnr• (i) pHrnnhar6itn/ and. 2-arrf~Jamirtufhtarenr [5:1-9G-3) had a greater iirductice rfteet on ('v tra~hrome I' di0.1 iu citan. in A-de.Gcirnt..ruls. 1-Uimclhvl= aminnn-ufx•nernc (611-1t-71+tre.n.mcn0 derreaaed the level of' c1'tOchrnme' I" 45aIn omLLrulratsmnrP. (hnn in (IcliciPnl rms. •1'he heUaticcnncnc uf' vitamin A wass si;miGran:lv reduced in. conlrul r:ns thnt wcre xier:n iitjccliuns uf f, Y-acetyLuninullunrene, or phem+barbilal. Hrruoln)pvrrne L50:-3-°-81 nnd 4-dimrthyl~ aminonznbemmnrhnd IG.s effect. . VOL, 6, No, 17,, SEPTEMBER 17. 1976 85: 42:142p C)lochrome. P-J'S0 of bovine adrenal mitochondria. Ligand b+nding:tolnvo forms resolved by EPIt spectroseopy. . Jefeuate, Culin It.; Orrne-•lohtuun, William H..;', 13einert, Hehnut (Cnlll: Agric. Life Sci., Univ:, tSiscunsin,, hlndisrln: Wis.).. J. . Biof. Chrm: 1976, 251(12), .370G'-15 (Eng); The binding of 20n-hydrnxychnlesterol, 71-deoxvcorlicosterone, and aminu;;lht= ethiinida to cytuchrume P-450in bovine adrenal mitochondFia was measured by changes in optical spectra at room temp. and by L'PIt spectra at, 14, K. The 2 methodss provided nearly identical quantilation ofthese interactionswith, cvtnchrome P-450. Twu distinct high-spin forms of cytochrume P-450 were revealed byEPIR spectra. Thepredominant high spin species.(Q = 8.2). wasdecreased by. addn: of"10m-hydioxychulesterol and elevated pH but wass increased by addh. of cholNlerol. The minor high~ spihn species (k = 8.1) . was increased by addn: of . deoxvcorticosternne. but decreased by low enncns. of inetvrnpone. The 2 forms were evidently not in equil. and.have beem.assrgned ' to distinct forms of cytochrome P-450 involved in, resp.. .. cholesteruli side chain cleavage (Y 45o,.c). and steroid 110 - hydrox,vlat'uon (P-J50n:d: The high-spin states are derived from tomploxes.of these P-450 cytrxhromes.wit.hendogenous substrates. which are,, rtsp:, chulesterol and deuzycorticoids. Ahigh-to-low-spin transition was.obsd..when these complexes were turned! over by iniliatinng hydFoxvl'atiom withmalate. -The contributionss of cylochromes P-450ue an& P-450.,<, to the low-spin spectrum were also resolved by similar means.. At.least20%.of P-450~ :is in the lowsp!n sLtc, whereas -90% of P-450aois lon-spin in isolated beef adrenail mitochundria.. Low spin complexes of tytochrome P-43U....with 29tr-hvdrnxychoicsteroi'and prrgncnolane gaved.istinct EPK spectra. Aminoglulothimide interacted with the total cvtuofhrome P-450 content Of the bovine-adrenalmiluchnndria furmine low-spinn complexes. Bothoptical and EPBH data indicated binding to 22 formss of cytochrome Y-4iiU. ' These resulls suggest a d'etailed mrrelhtian between the spin stateand absurbance changes.seen atr(am temp.,.illastrnte that EPIt allows thedistinction of 2 principal forms of P-15U, and su0pest that there is:n~ a.ppreciabletrchanl!e in the spin.slafeof either cytochrome between. 14°K and 300oK. 85:42659a Properties snd su6cellular location afenzymes involved. in steraidm;enesis. (and thue rolee of cytochros-e P-4L0). Cnwer, D. B, (6uv's:Hosp. Med. Sch... London„ Engl.). ' Biochrm.. Steroid iform. 1975; 105-25 (Eng). Edited by Makin H. L. J. filackwelli' Oxford, Engl. A rcaicw with 31 rufs, 85:42741c Characterization of env.,vme-like activity of human hemoglobin. Properties of the hemoglnhln-P-450reductase-coupledani,Gne hydroxvlase system. Mieyttl„ John J.; Ackerman,. Hollie 8,: Blumr•r, JeffreyL.: Fieeman,.. Linda S. (Med: Sdt.. Northwesl. Univ.. Chicago, 111.).. J. Biol., . Chem. 1976, 25101). (F'n^). Human Hb w•as:s charactertzed as nnemtme in a recun triuted anilrnc hydroxviase. . system conl . Hh, N4\UI H rat liver c7h chrome P-450 reductase•. aniliuc and atm. 0 Ih:ssystem catatrzed p-arnihdphenoli furmation (turnover no, 0.2'2 male/mm/mule of Hb) wilhh an' efficiency similar to lhar.whieh has been reported for either , microsomal cpt.achromeP-450ur cvtachrmne P-,IfiO solubilized' from mt liver. Thee ralee of the renctium was linvnrly depemlpnt'.t nn lib roncn. up tu •-•1'nmoln Of Ilbiml. •I•his Iiucar range of'f hemnetrzvme runrn: is al.msimiliv locvluchrnme P-4'SlFtalah'zedd reactions. Unlfke IF,e cvtochrumeP-•I:A.yslem• the tili systemdid not require.a lipid eol'aclnr tar m•ix: activity, :wd much less teductnsee uis nceded fur max. atlicily. Auilinn displayed' typiral MMichaeli.-\lente.n saln. kiireticsns sulktrate, anrl its.R. (NmA1),was Ilie.sanm in the ahsencernr presence of'the reductase. Catalase esseutiidlptvmtph•lr•Ivinhihitcdp: nmiiruphenul formatiun in lhe nbsonce ur presence nfredurlssr:. In cuntrast, suprruxide disnmtn..e inhilliterl', the reduclasr-rnrdinted reaclinn onlyto a small extent liflat nlll. No detectJilr H Oxaccumulated dnringg the caur.eo0 thereactiun in thealnt•.nce' uf camlase:. These Eindingx suggesled o hyputhctical mr•ahnnismo fur IIb-catnlvzed h,vdrnxylhtiom of auilinc involcinl;a I'Ih-hnund, form of 11,01 (nnilinc-lth0- -0011, ) as an intennediate precedingthe:rnte-detg. formation Of products. QOO' .0g199.8 976
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r A N N 0 U N ~..,E i"Y~1~N T S rAiL•:TI:vcS AND COURSGS INTERNATIONAL CONFERENCE ON INORGANIC.AN0 NUTRITIONAL.AS- PECTS OF CANCER - - The InlernalionaLCOnferoncaon Ihorg,mieand tJulr:banat Avp-,cts o1:Cancor will bry'held.lram January 21o 5, :977, al fhe La Jolln Adlaga Imr..La JOlla. Ca:Amnia..Thee eon!erence iscrganized by Ihe Inlernational Associalihn of9brnorganic S<ICntists, and is sponsored by IheNalionat Casar Institute and'nhe University of CaliforNa at San Diego. ' The topics will bei experimenlal, Ihn,oretiaal, and environmental a;pects of melall eareinogynesis: thelicalmenl olneoplasmswith malal cpmpb.ees: he role of trace e3emenls in'dCVClupmeml canCCrprevenl on. nutrition: and eGiJemialugy. Advance repislrahon is required. Since the numcierof parlic.camsislimlleds letters of applicatian,should:rncfude name:.tltle, alhllalion, references loowmwork; andd rescarch:inleresls. Send /nquiries to: G. N. Schrauzer, Cancer Con!err•.nce. Interna- lional Associalion of Broinorqanie Scientists Inc.. Universily of California• Rovelle College,.B-01A, .LaJolla,Calilornia9.^093. " ' ANNUAL MEF.TING OF THE AMERICAN ASSOCIATION: FOR CANCER. •RESEARCH':,.INC. . . Thescienti6c sesxionslof'Ihe 68th Annuar ldeelihp of!he American Asxcratlun for Cancer Resoarc.h, Ine., will be hold atthe Denver M/!ton Y.blel. Denver. Ccbral:o: from 8:30 A.M., WednofAay. Ma¢1B. until 5:00 P.M.. Saturdhy: M•ag 21, 1977. This m.cat!ng will be preceded bylbat of the American So^.ialy of Gludcal Onoologyto be held in f 40 same hotel om.May10 aud 17. . RegistrYion40r the Associationmeetii:g will be conducted only at the UenverHJmn andvdllakeplace during thea!temoon and evunrngoh7uesday. May 15, and throughout Ibv course of IBe:Annual Mretim Nlonmrnmbers:mayy ebla!n progmmsandpurchase abslraels of Ihc papers (fhe PEOCEEOIPLGSI at the 1!me ol regrstrauon. By action ol'Ihe Bnard orDirecthrs, a rea!strabonie^_ o15i0!00.willlbc chmuud each member and rronme!nbel'atlendrng thescrenlrf!c sessions: a:5pecral Gde of $5.00 w!11 be eharged pretloelaral sludents whopresent a statemenl, signed by tne r.•nistrcr, dean, ar department head oflhc!r umversrty or cn!I6eC. comflrminj Iheir stalus. Admission la Ihe sCrCnt!I!c'se5biuns xnd be restricted to popedy reqrslered nCrsans. A copy of the.detailed regulations invclv+ng submrssion ol.ebstracts and pre.senla lion of paperswin be5ent to CacC attive memberol the Assnnabon i.C.part at the eusfomary AnnualiLlullorto be rssaed in Oclobec 1070. Corrosannd:ng mem:)crs arrd. . nonmeGlbers may o3:imeoPrrs a' rhe: rcgu!atiortSand bp;el roservarfpn c3rds hom Via Sncretary-Aeaswec. Aic• dcad!inc tv: rccc!Pf:nl anaracls. Dece•m;mr 15, 1976. will'be enlorced srrlcrl y. Absl(acLa Ihat are submitled in eoo/or mity. vuuh the rogu la- lions and eonsiJUrod of aceeptet:le.ouai9ytwllhu pnelut•atl In,lhe Sterch 1917PIiOCFEQIM6S. oYf rnn Ameroan: Asxoa:,lwn lnr Conrcr fir.*.mlrcn, .ohlcn .dJ he mailed.by Inc publiatrer to all pardup subscnuer; to ttmloumnl CAIQCLR I1eSEN1C'rl. ' Hoqh J..Creech. ScoctarY-irrasurm Anerrean As.Goc,aOnrr loI Canee! HcSCaKb, Iht. The Inslitu/c fnr. Cnncer Heseash. - Fef Clmse, Plriladntphia:.lb. 19111 VoL. F, t1C), 17, SEPTEMs117R 17., 1976 00010025 1003 - . f
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_R9EW LITERATURE. . BOOK REVIEWS PCa5mt5 AT I11GH R/snOr CABCaa: AN ArPROACX TO CA]CEa Erlm:nGY ANn Covnou ediledd by Joscp6 F. Fraumeni; Jr. Academic Fress; Inc. . ($19). Exposure to minutc fibers of inert mineral asbestos can induce:long-dc- layed fatal tumorsof Yhe shoracic lining. a kind of cancer.veryrue imthe general population. But:men who w ork with aa- bestosquite commonfydie of'it: neuly a tenth olthose who die 20 years or more after.initial exposure die of'.such nn- eers: The,mene tlsc'v.doctorsandr their unions all'are propcrty concerned. Sad'- des still u that among these same.work- ers three timcsas many die of'the com-tsmnest form of.. cancer, cancer of. the lung. Thoee who shpw a high rate of lungcaneerg however;.sre members ofonly one group of asbestos workers: thatt majority who smoke.cigardtes. Long--expnscd asbestos workers who never. ' smokrd at[ all, or. who smoked pipes or cigars only. are a goird'dcal safen from Iung:cancer death than the ordinaryy white male. Cigarettes and asbestosao-_ to- gether pm.a worker at mulsiple.high, tisk. five limestlsat of m^_n hiaagc. Hiro-shima survivors display a similar effect: Tlsis volume of eapert papers from aa temnt symposium laysout the ent4ee current slory oLcancer risk. from,.genes to public education. Ir is a moryy full of puule and thrcatl at once a warning and, an.intellectual challenge. Can wcgrasp. the hints that the.complexlally oGfataltumorsf for every conditian of man and. • woman, oRerY? A cEild is born with no iris in the eye. There isa particular chro mosume error: the unhappy xore<yed, infant is apt to harbor a spccisic abdomi. nal tnmor by the rime it is three. Cancer or the esophagus is unusuallycommrmy on thc island of.Curacao: it ishcld' Ihatt the.catuee mayy be the heavy consump-tion of hcrbxl tras. folkmcdicinesmuch% favored rlsere. Carrinoeens havee been found in such plant exvacts, judged by Ihek clfcets on rutx, and"so the hypoth, esis aemains viablc" Gross statistics are never quite. emogh+ It is nOr thc mcre.error of.ranf dom.sampling that deceives: these spe+ ciSlists arc sophisticatcd enough withh thelr s:asisticaltvstx The true proRlem. Is snbtlcr. For.eaampler thr.cxposure of'infnnts in vrr.n to X rays has far 20)earsbarn a prisne su.spect as tlie indncer ofacum leukemia: thc malignxntproliferat tion of the while mllk of thc' blood. A rc<entstudysurveycd morethan50-001L children. Lvth w'him.and blxat. A third of 1Le children had:bemn rxpnsrd lo X roys brforc binh. therest wcre coorruls.. "ILe rnuha were surprising." Thrhlack children showed no cffrcts at all.froml tlsee exponne: I or thee while chilJrcn at risk. hnwrvrr:fivt.emis deslhs mcre upneerly threefn4d;'f h.a aeems:cnrsclhsire enoughin thissample.of adoxn zascs: IIU1.tbc.same nunple of whise chilJrenn shorrd a twofold inrraase in deaths from ordinary actidenls. Isynnd IikelM. Iluctu:nions, Chanuc is mtwksng ustirrrs or thcre is smne siranee unknnwn bua. Ifwl musl oasl xriuu> doubt on tbe su[-pecsrd caual connection. IVOL, 6~ N0 t 17,F $fPTEMBEP,' 17, 1976' For.tobacco:andtoalesserdegreefor alcoholia beverages, there ss such many- sided evide nce o0 risk thatt thee issnee ep. pears:to be beyond doubtalhe sfakesare trot small: takingg conditions as they srere in 1970 among American adult white males., one can expect that about  third would die before the age of.70. Of Ihes< mem dead before their time. more..succumb to preventable cancers Induced by.cigarette smoking thaodie of injuries as.a wholc. including those pused,by automobiles: homicide. stsi- eide andlhe war'in V iemam. In absolute terms of death and misery wc.appear to know tww how to prevent some 1UO.000 eancer deaths peeyear,abounone aan- eer death in three. There u a fearful glitter about those pagerof this volume that graph. by.tne . sile of the cancer. the deaths in city after city across the U.S. Is there ahealing paltern hiddcv there. if only we caa read it? Othcr mops show couniy by county the ageadjasted ra¢s shaded according to rank. Forstomch cancer the map.is overshadowed bva cluster nG welbto- ' do rural eounties.in the nurth-central stares: There is a reason. Thosc.coumies numba many people of Scandinavian descent. The:big world atlas Cancrr Un- dmrolA Fisr Continm:rshows.the same black anading.in the home countries: for stomach eancer in.Americans °ethnici!v eeems to be'.the major determinant of geographic variation." For bladder can- eer wcknowthap the aromatic amines are- among.g olherorganiccompoundi, spceifioeareinogens. British workmen who manufactured crrtain dyestuR in- ttrmediater. hzd about 30 times the death.risk uf'.-the general population fFom.this eausc. with a 20-year inouba- tion time. ft'is no surprise to.sce the chemical countiesof New.Jerscy black- encd on.themap of bladder canerr. but does Detroit, high rank suggcst.t an exposurc-pcrhaps quite mcidknlal-in th< eutomobile plants? Another appruach, today much di!- ''cussed. is toae:rtch for a laboratory car- einogcn in thcrnvironment and then lut Ihe causal ch::in by'Ihe expermr.ccs.of dailylife. Nitrosamines are powrrful eareihogensfor rats. These compounds "and their preeursara ean.bc found fre- qucndy in fiwd.....Thcy aou arar near the topaf es'cryone's food harard lisl." Common mediciscs can 7+ruduce tham in the stnmach, particularly under rnn- ditioos of roduccJ acidity. Thcy are furmud in the frying of bacon. Sallti.h too iss a risAfinor, which maY. show np in the high lap+mse rotc al .ssnm.rth cancer. buaansoked luh.and the qune dilfcrenl pnlqcydic hydrocsrbons it harbors overlap.p to cloud Ihe issne: 'There has'.1wcu nn diicet assneiatmn betw.een tbe.e eompounJs and human cancer evrn in [he indmtri:d. sewng." Ascorbic aciJ blorks mtrnssmne.fur- mationi so that m.rlbe the sanie indi- viduls who pus thvmvrlscs utirlsk by easing bevonovsry marmng may be pro- tecting snamclvrs by precedmg tlse ba- con with orangc'.jpicr." 00010028 . 1006 I
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ABS TRAGTS ABSTRACTS 85: 40402u. On-line dhta acquisition system for Perkin-Elmer 240 carbon. hydrogcn; and nitro¢en andlyzer; Harrington, D.. E.;: Bramstedt, {ti:.17: (Diamond ShamraekCorp., Painesville, Ohio). bficrochem. J: f976; 21(1). 60-9'(Eng). The Perkin-Elmer 290C, H and N analyzerw'as adapted for un-linee data acquisition with a remote computer. Sample uts. from a Cahn eleclrobalance were directly entered into the cnmputervia a power supply and interrupt'system. The outputsfrom the 3- thermall cond. detectors are monirured' for 10: sec and sicnal averapedd by the computer. The computerr takes alPdatal necessar,v for the.t•alcne of percent C, H and N and prints.out a final rePOrt on a Silent! 700 remote. terminal. The report is suitablee for direct transmissibm to. the sample submitter. Duplicate reports are printcd'i forr permanent'anal, records. The precision of results obtained utith, on-line data acquisition compare favorably toresultso calcd. manually, and provid'es a 38% improvement.tn efGciency. The on--line systemsempiov a PDP-15/76 computer, which is available for other (asks.. This provides snaddnLcost savingscompared tothe alternate approach of purchasing asmall dedicated computer.: 85:44983gBeduction efficiency of nitiates on cadmium columns as a function of flow rates of reduced solutions. Daniluk, Barbara M.t. Michalowski,.Tideusz (Meat. Res. Inst„ Warsaw, Pol.p. Acta Aliment. Pol: 1975. 113-4)„349•55 (Eng). Nitrates in tond are detd. by redn. to nitriteaom a Cd column and measured by colurimetry of diazotiredi sulfanilicc acid and a-naphthylatnine:. 1'he efGcienc~ of. Cd columns u'as sttldied. The effectivenessof nitrate redn. (v): changes withthe reciF)rocal of theflowrate..(x) of the soln. accurdiug to the furmulh rl = /F/(1 +/x)Lwhere ) isa cmut. characterizing the redn: efBciency of'lhe.cnl umn; i0 may, be used in comparingcolumns. 85: 3a028xGas chromatograpliic cartridge desrrption port. Aue, Walter ?..; l'ogt, Corazon It, Sounker, Dennislt. (Crace: Anal. Res. Cent., Dalhnusie Univ., Halifax. NovaScotia): J'.. Chromatogr. 1975, 1i14(1); 184-9(EnR). Constructfon details are given ofa cartridgesystem for sampieacquisition, tcansporq. and introductlion into a gas.chromattgraph.for anal. It.is used ihn studying the efficiencyof solids.in collecting.trace vapors in air with thermal desorption. Drawings of the collection rartrid.e, holder,, anddesorptilm port and off the flow patterns of the valving: system aree given. 8.5:43099m New methods of quantitative thin Inyer chrn= matography. 0'Intt;qold. I)~. K.; ,Uukhcriee, K. I). 113undesanst', Fettfursch,, lust I'f•clmoll Bi,ebem:, \luen<ter, Gerl fCrgtb. 8xp.6frd: 1976, "O(Purtschr. Cbruntntugr.. \tetl,udem. Ihre Anwend. 1(lin. liinchem.), i!i l.1' (Gerl: A review with t; rrfs- of the principle and use. uf the lhin-Ihyer chromatuc: scanner,, a device in wltirhchrometuy,h is perlinnrcd unlhu inside ol a LLdie, the or/f• compds. volalili'r.ed or pyrolyzed. andLlie vapors detected with a suitablee detcrlnr. 85t 3755^v tienetionss of dinitroeyL conrplexes. Cirtnlwlir, rcductiat of uitri~c uxvrlr.hy car;ron munoxidee to fornn nitrous oxide and enrumt dioxidr.. liii~more. Ilarrv I..;' Kirduk J A.: Iberss 1 m t, :(.. (Drn t.h m.• \urth test. tJuiv.,, Evanstun 111 )i fYoc f if Limf. t onrd Chrrrr 16111 , I.Iv 1. ia3,.. 2 pp. (Fag): Uuiv. Cull., Dubifn, DLP. CLem. Dubline lie;. In,contr.ist tnmostmtn.I n:.tfltxc:. 1r:StNU):Rr (uhsc P istripl:en}Ipho.phine, rv nactilr tuuardl:. rertnmn redutinp- nndl osidini 7 agenla It~U. Nl), IirNO, mul. Iir. nnd 1.:11r1. Thc iom. Irl`t1V0a rraclei1nitli CIU,-. Ir P:INUIr rracted with CU'toprepo lr f ICUIS + N:U. The ndh "NU aCU' •N:U + COsf wns.turb d widt oat d,,is by trl .IrvAbrltr, lil :INOh• nnd, Iheir121i au:duas Ths hent af rcdr...wus-91.:1 kcali,mole, nnd the,trcee energy oi' rtdn...wns-iti 9' kcai / mnle: VOL. 6, NOr' 17, SEPTEMBER 17, 1976 85: 36895q IOetermination of C04) by the dichromate reflux, method of some detergents, pesticides: and riverwaters.. Hanada, Shihjirn; Furukawa, Hideyukij Kltano„ Takahira'. (Meijo Univ., Nngoyal Japan). Afizu Sfiari. Gijutsu 1975„ I6(101, 939-42(Japan). Glurusr(1) [:70-99-7J,;truromic acid(1I)[56:-86-0J; and theirr mizt. were oxfdizedto stuay the oxidn. abillty of'f•ccmomcanatef and diuhromate. Permanpmtate showedd lower oxidn. abilitv than dii:hrnmate. Dichromate was used todetn.o the COD:of,Nh lnurvlhrnzenr..ulfbnare (1I1)'[_°515.i-3U-0J', No pentachlurophrnolare (d\') [:111-33 _J, 2,4-dichlorrophen=ox;nt•etic acid, I\') [91-7:-7J, 3I kinds of curn.. delerpents, and river waters frnm.Kisogau•a•.Shunaigmva, Horikawa, and Yama= zakigawa. CODc,of l, If, 111. IV, V were 88.5-1U6:2.i,.32.7-44.3,. 107;7, 80:0. and 92.31%, resp., tn the theor. uxygen demand. CODc, of river waters showed good re=pnnse: too polluted degree given by other datus. such as amt. ofsolf materials, residue uf evapn. and ignitionl and disso!ved 0. Y:Ishikawa 85i16'li6k Ozonelreatment of phenol-containing wastes. Auclnin. Paul; Lecguc, Gih'es (Entreprise de Recherehes etd'Activities Petrolieres) Ger: Offen. 2;516,969 (C). CU2C), 22 Jan 1976, Ft• APPL. 744 13,3d6; 17 Apr 1974;. 15 pp. Phenolic compds. in waste waters are oxidizedbv Oa in a reactor where the.ratio of'.Ipngth/crosasectilm is>5:1. ~The linear feed rate of waste water. is >0.75 cm/sec, preferably2-5'cm/sec. The utilization of Oa depends on retention timee and thc concn: of phenols and othes compds. reaclinn with pherml. Goodresulta are.e obtained when lhe retention time is. <3 minn and 03 dose 8-133 mg/ingphenols. A reactor line.d' with porous material allows a larger throughput of Os. T. Jurecic 85:..37467p Analytical expressions for theTelt•ntion volume'e in gas adsorption chromalography. yuprvmr.vi(z;'L.;. Jkronieq. M.; Gan'dzik,.J. (lnst. Chent., hwrie{urie-Skb.tdlnc.ka Univ., Lublin, Pol.). Chromntncrnphin 1.176, 91-1)„ Iti1-7(Eirg). The exptl..obtained'functiun.retemiun-voi. 1Ls) vs: pressurelp)'. approxs. an expommtr,il, hiehcrdevree poly'nnm.al cery well. The possibilit.ies of usiny, this approxn iu the dctn- nf euergetic hetcrngened.y of adsorhents. rn t•tli . nrlsnrptiun isuthcrms,.. audl in calcg theyas-snlide virial cnelts. are shown. The exptL. obtained functions YVIPI G,n tlle. ndxurptiun ul1 hexnnee and! 1-liCxene.on cnntrulled-parnsitvgln.cs illustrale thenr, consideratiuns.. 85:431'8'm Analytical system and analytical methodss bascd~ unon mass spectroscapy and liquid chromatography orgas.chromalorrnph)'. Hnrnine.l•:-C,; Corroll.D.I.p Ueidic,. 1.;., Hae6clc. li. I).; )inrnin)t, \l..G..; Snllwell, It. N. (7nstLipid Res., Batlno Cull, \led, Flnuaon. Pex.l. KoS~ohu No "lv):an197G. 109. 55.9-4 (.lapan/': AnewsyslemusingambietGpressure moizatiun mass spectrometryand gas orliq. chromatop. was d,scussed! A. hf111lukuma 85:3fiFOtl Improvemen[s. rt•In[inn' tothc aprcific Substnnces in various atmospheres,nhdCcnnnIna d 13ri1. 1 I.I :9tiICL.f;U1N1, 11 1-th I 1,0, Appl 30,45:1~73,. 27 Jwt 1959/~pp, A portuble, suLd atalydevice is descrthed:fnr detrrl'in 'Urepreceme af halnrrn-nunte: gtses, e.p Frrons'. i¢ the'nlm 91te app. c„n iat ul a cy'llndnral hody of a elass-cernmiemateri:d comprismt \,t tiiO;•. l.a_U.i (1312-81-KJ, and hnfn. [177U9-14-Ij pavmr• a Pt-wiie lerminnl embvdd~~d aluuc'the Inn;;iiudmnl nsis ;md n second termimd lormedfram 8 mil thtckness.l'1 wirc ruiled nrnuud Ihreetrrior surlitce. A: depletion layer is formed at Ilie surlace of thr body hvv a t rlyir.;; a voll'.age nf 1'~IU l"acruv lhetermwnik and by n ourrent through the coilyd lertninal in nrder to hcat the bndy In hIHI°, The presence of Ymnn in the alm. i. inditntrd I,y an increase in theettrrt•nt passinpK thrnngh the rlevice:.. A enncn. of "_u ppb8reon 11' Q75-iI-Sj ih the.utnr, c„nbc dutccted. 00010002 980
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NEW LITERATURE BOOKS fWARn-_.. ___.... 801.6d04 Atii•rrqrnr:•nsw/ tni+•rorrngmnrming handt4wt. 1,1 edmr n Itluc Ri Ifc SummiL Pa. . Tab1976c1975J 29 p. '2 un: Includes index. !}A7661tjrJ 7s.3IJF6 IS11\0•83065785-I : .95 ISIS\ 11:6.06-JGbc 6 phk. : 6:95 6.. Ali.'ruprcrccuurs. .'. .Ifn'rnprogmmn+irtg.. l.. Ti1k. I PINTAf1RO, Nicholas: 664'.5 Food naroni,.e processe•s'/'Nieholas D:. Pintauro. Park Ridge. NJ. : No5'es Data Corp., 1976, xii, 209 p. ;.25 cm. (Food technology review ; no. 32) Includes indexes. [fP4181P56] 76•5100 ISBN 68155:0618-X : 39.00. L P7avoring rssenres-Pttrnts 1.75tlk.f1• Serux BOWERS, David G:. 658A SJstemsof organizarinn :. management ofthe human raaourcef David G.Bowen: Ann Arbor: Universitgof Sfichigan.Press, c1976. vi, 166p:; 24:em. Includes indox. Bil:liuaraphy: p: 169-162~. (6.951.Bfi8 19761 75,3i0521SBN 00.17;-08172r1 f- £ikrrtj Rensis: 1903. I. .tfanagemenr, l. R ork jraups. -GOrgacizatiora L n'Ne. ZIEF. `,lurps 545 6'nnra.mruri:m. enntrel ind.nte clcnrensxn!sx's / Florris. Zicf; la:nesK'. -y!lehcii. 7mw° Yo:k.: SYilcy, c1976:. p. cm, (Chcmicol unalyeis; v. 47) 'AS4iiey-Interrcc¢nve puhiiratmn.` Indudce biblia6•rn~lrical''rcference.s and indn IOOI39:Y7JSj 76-iFnJ7 ISBN 0-471-61169-7 : 19.t0 J: Tnra•.e eJc•nrrnts-Ana/yss 2. ('uniamimmnn [f"hrrnlrgs) L Jlirrnr/l, l.tmrt' II', ~iniu' awhvr J'f. Tirle...l11. 5rr,'es. / CARBERRY, Jimcs 1: 660:2'9'9 6hcnuiW and,arahli: reaction cncirtrrrir Jamt•s J. Carberry: kcw York : VeGnw-HiIL. e)976. Pc em, (Ele(;mw-HiII chnnieal enpincerinp series) InnhniesbiFlii.eraphies. 22:50 ~7 PI55.7.C37J 76-1963 ISON' 0•07:007790-9.:1. Chrtnttn l Pro.rs.cex 2. Catelysis. L'fi'ilr. MATTI IL54'S;. Dnn 0: 658.4'032 7he di•xign n/ the nrandernirpr inf,mnatiunsj'slrnrL by Il,.n (J, ?.16trhrws, Rcr. rd. New lork : PllracdlJ4'bartsq 14tn. p r,n. Inc!udCs hitrbuonph-c, and mdcs .1tl'5%.6l V!7' 1976J76- 249U615UV 0,98aU5•37t~-}:: I:9>. li Af:nragcuwnFinlJrrnanotr.sorrrns f 7)'tlt.. VoLr 6, No, 17, SEPTEMBeR 17, 1976 AhrBlff:Nrair6(4]:1'0973'. qua7iry sranJarde-hcrr wr arc•xhar dn we Jn?' : ASh1E Air Pnlliniun Control Diviunn fourth national s'amposium. St Louu: Stissouri, Slutch 24.25. 1975. l1 sponsored by Air Pollntion. Control Division. ASME cditcd by IFillinm 1.. Moroe, George C. ~S~,cdcnu:n. \ew York : Ameriean Snc¢ty nP Mechanical Engiucers;.. 01976. vi, 264 p. : ill. • 26 cm. Includcs. bibliographical rcferenees. (TD883:2.A6a7J 76-364917.30.00 - 1. Air qualitymzna•remenr-0nlrrd Srates- Congressrs. 1. Ifornz. Is7lfiam. ! /1. II7rWcrsum: Geotge C..111. •Amrnivn Slxreir of .lfechamcal Enginecrs Air Pallution Convol Dic+sron. JOHNSON, Ross I I. 658.4'03 Quanritarire meMndc for mar•a¢cment /Ross.H. Johnson,. Paul', R. N'inn. Boston : Houghton MifOin, c1976. xvii. 417'p. : ill- ; 24 cm. Includes bib5io8raphics and ind'cz. (H)20.5.J621'75:-25239 ISBN 0-395:-20633-2 :..13.501. Operations rrscarch. 2. Irirluslrial menagemrnr-.wtathcmtical made/s. 1.. IfSnn, @ad R., joint authnr 1L atlc. RAMrWINGA'Sf, P:,. 19a1~ 658.1'032 Spstrms ana/l:.is f.rt n•rna;crialJeciririns: a compulcrapprnzrh iP. R.,maii:,gam. New Furk N"ilcy, , (1976I.1475 p. r'm. ' Includes bibliuprapb,cs end indcx: II!t)'_0.51R351 76- . 1053a ISUN Oai.I-70i10-1 : 4.0 1. .5',i:acm. i.+. 2. 1r,J~nmirl mmnntemrnr- Ala+ncrnzticrl iarul,,sraodrJe: 1. Tidc. . F READLS'GS in mansgement 658.475 infnrmanon sJ'strms '. edited by Gordon B. Davis and Gordon C. Evcresr. New. York : McGraw-HiIL c1976. xii. 284 p. : dl. ; 28 cm. (A1cGraw-Ilill scries.in mana¢cmcnt information systems)Biblin.raph >t: p. x-xn: (T58.6.RJ:J 76- 7954 ISBN. 0-07•015835-5 qbk.:10.95'. f,.Afenagement infurmatinn.s)strms-ACdresees, cssays- lccmrca L Dar'rs, Gordon Bittrr.11. Esrrrst„ Gnrdun. C. KREY, Isabelle A. 658:9'S Ptinriplrs anJ rn'hniqucsnf Mk-rri,r buvncrs cornr•.rani;.mim.:t a rau-wnrkkxik 7 IsubdleA. Krcy, Bcrnadcue V. Slcix/cr. New 1'ark : Ilareourt Ifrace luvanmich: 0976, xi. 532 28 na Edniun fur IynB puhli>hed und'cr tPle: EI*ecl{se wrninec for budi,ess. Includrs index. IHIf57IB R1J 1976J75-J5520 ISktN 0.15- 57191G-8 pbk.: 7,95'. f. Conrmumcatrnnia mansecnrcnr. 2. Cnnrmcrcial ,~+rrelvmJrnrc: 7. B,isinc+s rcMvre wrtnlrF. l. .tletzlrr. Brr.vJi•tte 1:: /u+nr author. IL: T ir.'c•. 00010031 1009' a
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1 A ,i BS TRAC1 S ABSTRACTS Tobacco International August 20, 1976 Vol. 178, No. 17, p. 42 INFLUENCROF MANAGEMENT SYSTEMS, CULTIVARS AND PLANTING DATES ON FLUE-CURED TOBACCO PRODUCTION: I. AGRONOMIC.CHARACTERS. Gooden, De Te et al Mamgement'.sYStems fer fluee.eM tnbaetu INieoRans tabacun - 11.11 :rvctnng vsrialions, in toppin, heiehl•. number o, harvuats, . . planting dalC..and eullivars.wiln d.werenl'ripwling paltMry weree eempived with a eon.entional s»sam.oe'tonpine'.end'har..esbng . b eqluale theu inllueMe on'yield and nualityy of Ilusiwedi ' bseco. With iM cen.xnlional aystemi18161. Icbacco ras..touoed '- at Ie leams ano narveqed sis rmes; Tlie reducns syssems con- - sist<d of an 1&leaf lopping eanested three pmec'(t3/}9, a.IS -feaf toesIng with Mu..h.rvestsIl5:2par.d a, 12aeM01ocpirg wi<h aenceaer harse.l 112:11. In eace W the svatems. the numbar - - nf kaves.eer unit are. was kept ccnebnl by Irmdlbcaeion ef el'anl'- pbpulalqn. In addilqn, ry.stams witn mcreased leaf numb•_r and M ferlililation were usee for the 12-Ne1.112/1/H1 and 15-leal, (tS/2(-)) sysams.. Enluation of'the syste's..blwlxd yiads.b> staRposit-wns,.k harvests. and tlie complele plent. Other measuremenls.taaen in-- eluded dppars/apmtal and anLysis of the USDA grade distr.butiom. 10 gmup. Cuuly. and color eategeries,.and the toba¢ce ccnrl peies' usability avaluAion. Cata were also enlleclW on the rcla.tian betwecn the date.of planting and I/K date of narvestl. --"'- '- The 12-ieaf topping wirhione hanest n•oduced substantially lanrr y;lds enL suptle. pvalily aneralione of Ine.lobaccn These yhtd losfes werc primanly due to evenloteess and las[,o1 lower leaves. QueIty altentiensin the tenacce /rom nnce-oeer syslems woe cherecteriaeo byy enanges, in Ihe.. USD.lgradedislnbution. The intsrm:ymre eyaemss 15: z1-I and 1111 ', oreouc=d yMds and ' emliti epual In tnat:of tne. conventiunal.sy[1em: Theee adwn. bgas Glustne pot¢nlial labor saunqsanJ ecnnmmic gains.mahe the.1512(.Par.d 18•3 IeasibleeYstemsl Date cl plantingEak o/ Farwst relalimnvhios were evaluated by, using the Clinbng dates loaengtneo llm.harvest seasnn. Hnw. . eror' prediclinn p/'Iha..harvesEinter.al irun the planting interval. . ia unuallyy impossibk:.. Journal of the AOAC' July 19.76, Vol. 59 No.. 4, p. 734 TOXICOLOGICAL TESTS' BIOLOGICAL PARAMETERS AND THE ACUTE',LD50 TEST Sperling, F. & McLaughlin, J. L.. •(he eeuse CL.a ir ew fnadpuate lede:e eEIoeirhy bmu.e Ihee.tentn.pbrof dealh o8& eturs Ihe.e mechenlenn and eitrr of etsiar-]Tuy. ••nklbel'. ra.ieuy i .alueud- end dre.. LOse 1. ms tatr.pnlus•J me'be pu••ihk eRrcssu uf luw 1'e.d spurue . fur Inn, nmud: ohlnm. Cnslebnr.u.r .IVdiw sbuuld be. under/elm . rr.wntLly. ..hirb •,uld deednp rnetlrudr m Irr'rIYN~.Veh evalualiVnandaellapW.rio6 Journal of the AOAC July 1976, Vol. 59' No. 4, p. 756 . -P'RESERVATIVES AND' ARTIFICIAL SWEETENERS RAPID SCREENING PROCEDURE FOR THE' DETERMINATION OF . PRESERVATIVES IN GROUND BEEF: SULFITES, BENZOATES, SORBATES, AND' ASCORBATES Karasz, A. Be et al A procedu.e is drecribed' for thes.minnien d lerge numben of pround beeE'semldn fnr tlw. 4 mal aoan +nly ue<d presmtHm. A dnde eamlae.Wnuonie 1•reaerea end eueuwe a.o teben forthe . s lests. 6WLIe.i.drae.. mtned enbrimernrirall.•u.id, ar'rd-bleechrd p- .. ioaaniline. Aworbicc acid b lilrared wid. 2,1: aiehlnrWnaepbtnnb. Ren..it and .•wbie aeida are.m rur.d.by uls.aviuks ab:orfuion. \egc: IRe aampite m repidiyy soned nu m this procedure anC IwNrhMe eernplcs are romplrred for yuenGrnl.eadnerminnlen of he p.eeen.- al:e. Rtco.eria . e 95^,. for sodium eutflr. 103qt for rodium bensoue, 90^.gur pott..ium aarhule• and 81^ e.ptrsed r r for sndium aseo.¢rsa Theiimil ul dernlion in0.00iire fore pouWvm earbam, end' 0.01 7- for she 33 otheer preeereesi.ea Analytical.Chemistry September 1976, Vol. 48 No. 11 , p.. 1566 GAS CHRO1"tATOGRAPHY/MASS s SEPCTROMETRIC AND NUCLEAR MAGNETIC RESONANCEIDETERMINATION: OF POLYNUCLEAR AROMATIC HYDROCARBONS IN AIRBORNE PART'ICULATES Lee, M.. L., & Novotny, Me A prevlously.desiqned nnnlylital scheme has been applied lo. the slructusal'analysis W polynuclear aromlic hydroearbons. In air-pollution parliculale maller. Ylell overl0p polycycllcs„ - 4Kluding Imve alkylaled Enmpoundf, wcra Idenldied Uenlthe4' ehrumnloyrnphic Eeharlor, mxss ape<Ira,:and NMR apeelm. WiOh sepnralinq powec of ylass. anoalary columna provlded ~. resolulion cl Isumerlc curnpounda wuh d:hmanl posilion u/ an, . alkyl group. Iho presenca ol •.vi was nlso aseadslned by . Faurleo-lrnnslarmNrnR: 00010011 ~ 989' V(11 . fl. R(1-. 1.7~. SFATF!-1nFp 17.. 1W& : .~-. . . . . ~ . .. .
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r s 1 VEW L.rI 1E8 \ATi.J'8 lE BOOKS rGRIMALDI. John V.. 1916-658.2'S Ssler mawgcmcns f Jnhn V. Grimaldc. Rollin H. SYmands. 3d rd. Hbmewood,. III. : R.. D. Ir.in, 1975(i.e.1976), uv, 697, p: r: ill..; 24 an. a r Irwin series in management and the haviural sciences) In earlier editions. Simondsl name appcared first on title page. Includes biblingrap Bieal references and index. ffID7262.S55 19751 75-16638 ISBN 0456- B1564-3 : 14.95 L lodurtnal safctv. 1.Simondx Rnlfin H: Safety managemrnt 1L.1'itle• - E6K, Rofrr D'. 658.Y071 Oprnso'unr n•snrch (nr business / Roeec D. Eck. Bdmnm, Calif. :Wadsworth Pr:B.. Ca:,. 6976. avL 7577 p. : i1L; 25 cm. Indudcsbibhue_raphical rtfcrcncs and indcx. HDi0,5.E2.]. 75-8036 ISD1 0-5J3-1I0J23-Sc 15.95 C Opnarimvs rr.r•srch.. 2. fnr)•.rstnal 'trunagrnunf-,lfathrmatnn! models. E Tii/e: A.SIERICAN chemim. 540':92'1 B and'ehenricai cngLzeers / R'yndham D. Miles. editor. N'ashington : American Chemical Society, 1976. x, 544 p..: 25 cm. Includes biblieeraphical refcrences.and index. jQD2I...433] 76-192 ISBN 0-6312-0278-&.: 28.50 s. Chenn'sts-0rnltrd Statea-9ingmchy. J! Chrmical engincvzs-6nita•d' Sfaroa-1/iogapiry. fL dlile;D')'ndham D.; 1916- RAYBURN. Letricia Gayie. -658:8 . Financialmollsfnr rnarAOlin[ eJminis:raram / Letricia Gayle Rayburn. New5brk.: AMACOM. e1976. p.cm,.Cncludcs indea. [HF5315.13.R3Y9] 76-13897. ISBN0.8133-5423-2 : 1.9:95. l:,glcvlrting managemrni. :. AfarAcrin;-Costt A dfarReting-Finance..1. Tiile. W HITEHOUSE. GaryE. 65Si4!084 1938r Afrphed aprrannns research +a survey1CaryE. Mhnthouse, Ben L. µ'echsler:. New Yurk ' Wiley,. c1976:. p- cm. Includes bibliographical nelcrncces and.iiWa. [f57.6.8'6] 76-16b+5ISBN 0r471-94077-1 : 15:95. 1:. Ofa•ntnms reseva•h. 1. Bechskr; Ben L. 1911-pintaurhosll. Titk.. t TOSI, Llcnry Ll. 65B.4 hAnqcema•nr : cnnsineencics•. structarc, and prrwcss. I Ilcnry I',. 7osi, ltepha, 1. Csrrull. Chicaeo : St. Cbir I':v.<. c 19'6. s%S p, : ill. :'3 cminclede+ indes, uibli.rcuplly, p 553-567. 'IIDJ1.T635], 75.J32sd ISB\ 0-913 42-04-8: 19.50 d' Alan.rgement :: Or.:rnuariun. 1. Carrul( Srtpha•n l., I9Jfrj,n)rt aurhut 11lidt. , ,VOLr 6/ No, 17, SEPTEMBER 17, 1976 ~ NATIOVAL , 628.5'3'20153701. Rescarch Council. Panel on VaporPhase. Organic Pnllurams." Vapor-phasc organir pollutants : volatile 6ydrocarbrms and nxidStmn products /Committcrnn Medical and Binlhptc F.0'uctsof Environmental Pollutants. Di.isinn, of Stedieal Sciences, Assembiy nfLife Sciences. \ational Research Council.N-'uhintton. Nationsl Academy of.Sciences• 1976. xiii. 411'p.: ill.: 23 tm.(Afcdical. and'd biolocic cftccts of environmcntal prdluunts) Includes, index. Bibliography: p. 329-399. (QPS2.2,A3V37 19761 76-609# ISBV 0-3D9-02331-2pbk.: 13.00 1. Air-Pntlunnn-Physinlaglcall cllcct. 2, Hl'drocarbons. ;L Oxidation. SITTIG, Marshall. - 688';4. TuAscco substitutes / Marshsll Sittig; Park Ridge, N.J. : Koyrs De!a Corp. 19'16. ix. IBi.p, : ill. ; 25 em: (Chemical tccAnoloevv rcview : no. 67) Includes biblmgraphi:aF refcresua. fIS2249.SS7J 76-231gIiBN0-5155-0616-3 : 3600 L Tob.ccosubstiro:esa Title. 11. Stnct WREN, DanicLA'. - 658.4 Principlrs'nf m.anagrmrae-process and behavior / DanieLA. Wren. Dan Vmch• Jr. 2d ed. Ycw York : Ronald Press Co.. c1976: x,.618p: : ill:.; 25 cm. In the Is:.cd. D. Voich'sname appeared Ent on t:p: Inclcdcs bibliographies and tndlx. [HD31.V58 1976]75:3347212.50 l. .S7anagcmcnt. JL t"oich, Dan, joint authoc. IL Title. . M'ALTER, Charles, 1936- -5471758. Enzyme rrartions.anJ rnn'mr systcros /Chades Walter. New York :\L Dekker. e1976. is. 204 y : ilf. ; 24 cm. (Enzymology ;.; v. 4). Includes biblio nphical references and index. (QP611 F 2431 75-22780 ISBN 0.8237-6299-1 : 19.95 I. Enzymrt 1• Chenricall reaction. Rate of- Alathemarieal mredels: l: Tltle.. LUCAS HenryC. 658.4'03 A r•asrbrwA.W fim m~n,v~cmrnt' inforr.rarinn s'stems / llenryC. Cuns. Sr.•and Cvrus li.. Cibsun. Ncv..lbrk.: \fcGax:-ILII• cl'176. xi• 399. p. : ill. i 24'4 cm. (\(cGnu-19ill scrics in nr mpcmtnt snfornution s)sren») -P'rittcn spccifitally to asnmrany7he analysi:, dcs'i?n: and implcn:cnaauon o0 fnforuntiim sl'ftCmG. V 58L6.L6JI75-36521 ISB\'..0.07•036938.1 p6k.: 5 • BA\ICI,..lsan S. 658'.003 Urcni,n:rrc ol' evw•frlvim anJ' ncm:rvernonM1 . aurhmilatlv4 cmnprdunwcc / Ilan 1. Ilanki. LmAnpclas : 1y.lcnr: Ree:valL.0qn..?7r, p. • `3' rm Pd I auphy. p. _7167. h IiIf71v Is13 . IrI701 7J 1 r t t I\It\..q nl?..It] 113-J : I195 l. 11.rn.;•nnau-U!rrs,narrcc -. J4rsnnnell ntauaprurrm Dn /rnnarn... I., l itlr. 00010032 1.010 . _. ~._: ...
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t ABSTRACTS ABSTRACTS 85: 41820r Induction of cytochrome F-4S0 and vitamin A., Study in the pis;g under thee influence of DDT:. GFaillot„ Claude7'.. Gak, Jean C,; Ferrando, lias•mund; '1'ruhaut,. Rene(Foc. Sci. I'harm: Biol.,, Univ. Hene-Deuartes, Paris, Fr.). C. R. Hcbd. Seances.ACad, Sci:,.Ser. D 1976,. 282(16), 1561-3 (Fr). ~d b/ 1 Feeding pigs.DDT (!1 [50-29-3j(150~mg/kg diet) for 10 days increased thehepaticennate nfcytnchromek-4.50 [90Si-51-2]I and lowered thee hepatic.rrlinnf.(ll). [48-28-8] reserves. The degree af these chanKesvaried amnng.the individual liver Inhes.. 85i 42956b Cytoehromc P-450lrom bovineadrenocortical mitochondria: two specirs, of subunit. Tillev, B• E•; {4atanuki, M.; HAll,Peter F. (California Coll. hled., Univ, California. Irvine, Calif.). Hiochrm.. Binp/rte. Rcs~ Commun: 1976, 70(4), 1303-7 (Eng). Electrofocusm ' in ureaan& electrupltoresis nn No dodecylsulfale-puly•tcr.damide gel at low-ienleC strength revealed that cytochrome 1 430 from Iwvineedrenncnrtic,d milarchundria consists ur 2 subunits presentt in sloichinrneltic aints. of 1-to--l. Thee subunits, aie tentativelv desigm:tcd as I andlIL. Oulpsubunit 11 is aa,.xd. withd:eme, It [srouwa pparent lhat the active furm of theenzynre consists of 16subun ils (1,--I la). . 85:35103t Hydrnulic resistance during ascending flow off a two-phase dispersod-annular current in cylind'rical channefs. Sherbakov, V. Ni: Nikolaev, N. A. (Kazan: Khim.-Tekhnol. Inst, im. Kirnva:. Kazan, USS$): /iu. l?yssh: U2hebn. '/.aned., ti/rim. 67rim. Tckhnnl. 1975.. 18(9). 1i1a1-4 (Russ)., Gruphical currelhtions for pressuredrupin lhe:2-phase flow of air and water at 2u° in IJ 5-20mrmdiam..tubes, 200-860 mm long, for air velocitiesaf15-55m/xec and liq.. flow d. 0.495 2.5•1 m3/in hr were obtained as functionsnf these variables, The results were exprr.sedi bv; I.Sp/,Sf1d=AlVeq+; where p is the pressure drop.l tlle.lube:length, d the.d.e tl'r the air vdncity,. and qtlte: liq. Iluw, rate. The results agreed well with published data. . C.. E. Stevenson 85: 41..901t. TLtrchcmicall formation of excited states during, hydroxylation of ttic carcinogenic hydrucarl/on.b¢nzol'~IPyrenchy liver microsomes.. 11.11711311111, 1 1':; Scltger:. H. 13. (Dep.. Biol., Johns Htrpkirts. Uitiv.. Baluittore, \ld.). Biocltern.. Biophys. Res: Cornmun: 1176. 70('J), 075-80(Eng).. Thr t' enzymicc hydrnxvktlion of carcino;:rnic nrnmatic hydrocarbnns. prrtluced pruductlnol.'.t irtchrtronirallv nxcitcd st:ucs. IntroductlumI of Grrmoln/(;irrnc,tUt [50-:1'£=8] into licrr micru.otnc•. Irant. 3-metbylrhullunhrene-inducod r.rtsnzultrd in a si;;niticant. ebrnriluminrscence. x•hiuh was shun'n. I:nr the ttnt time to Irecorrelated willi the enzymic lirdruxylatiun of the pnrmrtt eareinngru. '1•he kinetics af theehemilumiurseenee implied.thrd intt•nncdiol'ccpaxlde as llic precursor to the excited state mrnduct.muli:,, . VOLr 61 No, 17, SEPTEMBER 1Z, 1976 85: 42891d Magnetic circular dichroism studtes:. 43. Oxidirrd eytnchrnme P-45t1: Magnetic circular diehroism evidence for I!hiolhte ligation in tlte substrale-bound.form. Implkatiuns for tLe catalytic mechanism. Dawson. Jo1mHaroid: Huhn...R. H.; 'frudell,..l:unes K.: Barth, Guenther; Linder. Robert E.; Bunnenberg. Edward; Djerassi. Carl; Tang;.S. C., (Dep. Chem., Stanford Univ:, Slanford, Cabfal J. Am, C/tem. tinc•. 1976, 98(t21, 3907-9(Enq) . The magaelic CD spectrum of oxidized, substrate-bound, high-spin cytuchrome P 450r.,_ is comparedd with thespectra of various model heme complexes which weredesioned to probe axial Feligation by.several possible aminoo acids. Only the model withh a thiolateligand reprodluces the shape and strong neg. intensity of theSoret magnetic CD band of 1' 450r.m. thus pruvlding strong evidencrfur axial.ligation in. this state of P-450 by a cystemec anion. The implication. of eysteinate ligation on thereactiun mechanism of. P-450 iss discussed in terms of its ability to Lransfer electrntn d. toFe; thereby facilitatingthe.crucialidioxygen bond cleavage leading to an 0 atom-bound species capable of catalyzing hydroxylation reactions. 85: 41506t Thc effect of prolonged administration ofallyl= isoprapylacetylurea to rats on uyl.ochmmmel'-450 and other liver hemoproteins, Rumsctt, G.; Johnston, A. (Aled. Hiul. Rcs. Div., Sanrluz Ltd Basel, Swriz.). Xcnn6intirn 1'J7G„ G(3J„ 15l 7(Eng): VAfi'oprop.imetylr:rea (1): [528-9°-7 '. (400 m6/kg s.c. dai'y fu IJays) administerod Gl rats Inwere . liver cytochrome P-d5O [70,5-51 '] and catofaso [9011L-0~ :,,.. and increased 5-armnolevulinic acid .cyn(Iretbar (7NZ-1d-3]. Cy'toc/vome bs [90II5-39-6] was mdy margiitally affected. Thee ratsrecnvered's well frumthis treatment and the parameters measuredd reverted to normal. A mechanism.for the intracellularr action of Ii oncytochrome P-450 and other heme-contg:.compds. is presented. 85: 42273b 1'nsecticidnl comnositiunsusinlC 3-phrnoxYben'tyl 2,2-d i mel lp• 1-:1-12•2-rf i n h I nr+r v i n Y.l I-c.vc le l+rn pn ucca rhox y la te inscclicidb with osyncrgistic cmnpnurnd uf nmiw IaiAyl'. undd alkenvhm•monmc#u nik.nclarclGnusphnoatc..: \Innlgente:n; Itunalrl I. Incau, liarrt H. hP,U/. /'r q.I L/ S {;91I',G(i1i ICI. 4244J9', 1111 V/I 16 hl ir 1) b• Apl r nJ IT" 2 Inlt IBf,6;. It/ pp. CnnLUne,niun in part'.e t 115: 3 yhLI Il Synu r y ir. inseclicidq comhinatiuns nfeslers of rvclnprnpanccarbmylie arids (Pyrrthrins or pyrr•Ihr rdv) willt' Ih pho.phlnuv. Itl'I[tllUll~llUlY'1 (It = 1'h or 1 6(,lis R' = dkvl It- = nlAcnyll nrr pre.entr•dl Thus, thce nn.rtalitY of hou.rlbrs expu.rd hr holh f'r 1 prnpynyf p/tnrry:phu.rphnnnrr [IV711:-22-I]:md brn:rb:i (irroll-mrrlr,vf )2•:1-J-rctrrurtrtlnfi:.~rlnpropnnrrnrhuxclntc (IVS77-h9-9[ was 10t1'7n• whe.reas Ihe..nmrlnlily w;tn <OUSb lirr those expused to the phnsphunote or culwxylnlc indii•iduallv: s 85i43825v fron contnining' inclusions i,: chloroplhstss of. Nicotinna clevelandit x Nicott.tna gtnlinosa... I•. \-rayy micro:umlysis and uWrastruclure :iprcy, li.; Clicm,. G.: Janussy, A. GI S. lhst. tSot.. \tikrabinl., KcrnforschungsanluRe. Junlich, .ludlrh, Gcr.), Z. 1'jlnn:rrtphpsinf. 197G„ i9(?I, 165-7G (Hr._~l.. Cltloroplluas of yuun¢ ,Nitotic:no lcavcs'cnntainnd' eloctran-densc strenna iuclnsions Idinmeter. lka-11.1. und. Thev ean he dulroted in.un.tniurd thin-srvlinned mnterial exdusivelyfixrd iu IflularaldchWdc:. 'Plmugluditferent in nppearanm frnnr Fe-conig. Cr)5t'. plrqlotprtitm. il is assulned that Iltese inclusinn%'s mayrepresent.n runccruhle Ihrns ol'plivtnlerritin. 1•hisvicw. ixeunhrmrdiby xorov mirra>mnL of lhin°scetinned,.lllutimldehvdrtixed mnterinL.. Cnn.ideraGle mnts, of Fe and 1' a•cre present in Ihc electrnn-doncr inrlusfun. 'I'he mean nt. rntiu.nf hb/l' delectedi by x-rrn•mirroamll: u•n+2.5• (:ru.s.nrrangenmm of phtyulcrritinin thce plaHid ..thuma is di.cuwsed in relation to differt•n0 slatesof's chlarnpLlst duccluplnent-. 00010000 978
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ABSTRACTS 85: 422'0s Persistence of Iriahlorfom and dicklorvos ihn two different antoclavedand non-nutoclaved'..soils.. Guirguis, Itl. SV„ Shalik,. AI: I'. (F:rc. Agnc., Alexandria Univ,. Aloxandria„ Eqypt).. F.ull• Enromof: Sur.. F.prpt, Econ.. Scr;.. 075. 8, 29'-32 (GnC). Trichlarfon. [52-f8-6j!ant( dirh.foruos. 162-73-7) were degraded Inure rapidlyiil nonautoclavrd than in autndav(d snils and more rnpidiy in: calcarnms..nil of p}U8.1 than inchry suil of pH7.9. I'hehalf-life valucsfor trioclrlorfon in autuclaved',clay and r:alcarenussuils:nnd.nnnautorlaveds day' and calcareous soils were: 1.55 1 4u;. 1.15,. nnd' 1'..05 days, resp., and the values fur dirhlorovos were: 0.9. 0.85, 0.75,. and 0.7 days, resp. Factors:contribtrting to.degrdno of the insecticide were.te,e presenceof.soil microorganisms iu nonautoclaved'soils and,pH of' the soils. ' 88:40lOlve ' Experiments conccrning.g thesuitaS)lily of vneuum FIL): for ttuantilnlive [hin-Payen chromatography, ISohl, li, G.: Neufaldcr, Id:;: Pi!r'cmaYer, U:.. IL'srtelle-:n;1. e.V:, Frankfurt/9fain, Ger:)• G17"Fachz:. Lab. ttG6, ?:112). 95-6. 98 I (Gcr). An app. is dc cr Ucd whichallnws evapn. anu p)'rol)sisoforRs suL•stances, sepd. by thin-layer chromatug., directly on the chromatog. plalec. Ti,e app.ic combined witit uvaeuurn f+amo.innizatioudetectnr for the tmmediaw detection nf the:pprol)zates. Sorbitol'..was used as an example. The relatiyelv high content of org. binding materials.in, the thin-layer lihns inlerfcred in.the detn. 85: 4tf33Ay IDiOitnl ihteFrntor. Sis•stkn. Afiin lrv Nikolajenko, Vladimir (J.-Hevruvskvlrnst•..l'Ir. s Uhem. IClrrlr rhem„ Choeh. Arnd. Sei., Pr.rguaC Lt ul.l, C/ r nt ,lvrp• i'J 5G7111.1), I-U2-6 (Czech). A slinple dlxil d intr•I:r•nur turs ronslru tr& lo extend tlier:wteof'In<chrrmadgraplmltprnvdm7;.mrur triiaogrstiun: of the pr•rknrres• '1'he princip4 is h:re-d.au trltr.c,nd of the na ul' impulses tho.frequrnry'nl which isnirectlvl prnpurzionnl tn Ilic• input cull:;:c in n.gi4en.li:ae intcr•ial. '1'he inlr;r:uur c:ns tested in a rhrumatog.ditn, of COz and of prnpplcnc u'ith nn nv. error ur. iU.55'e. -B• Erdns 85: 3G73Gp Industrial losicoingy. Chlhhert; Jcnn W. (0.1nv and finkco Lid!. DaKenitaml".=,rx. Shel.). .tfod:. Tr.•nris Toricof: 1°."7, 2?6-L15 OI?m:l. 'fhr de':ci::pnl•_nt uf indastri:d taxicolof. factors in rl^t¢: prmrsihla htclt cf u*pnsure (threshula hmit values), clinicai tr tiq„ and unal. pruccuures.are reviewed. 3 A. Sutton 85: 196401) Stasx sln+ctromctry. ETnettner. Jucrkrn (Dresden, lr Grr ). !d r r 4. 5! vl ch, Ur n.r !'o.atrc! 1 t. 6, Tcil I', 371-d98 (Ger). h:i4d I.•rm:abr t urt Akrm lr ImfL. Ccest & Porth f:G.: Letpzig; L,.ll..un A reviewu'nlr nwreth:n 313 rcfs. 85:4Uttfm. Psc nf rlvn.irvmrisurinp dts:ice in liynidehronurtourll +1`hrrdI I.l:utrt Uirrur.us \.l•.,G.rnh:li.l. Gcr. Otfr.m l:ii u}u: (I,LCu: N), 1_ Frh~lO 1. lupl. 1' 1d 1Y 0e(:. +. 01 r\r„ r9i.-t• 9 pp. A It 1.<~hrr ntaln,dtt .r I n has,ti on d. :rc:. t•r.n nt 1.111 Ix u::rJ tr idrntifc an+dylr... wiu•u th.. dl difli•rrn r. haoctnt'e nt hdapi - and the.mdUru is.uf'Lii•nr e.0.0.U1' 1hc cinmt Ilurca lirrrni-n it li.-ur \ slr•qrrd viur,lirs:;tui,c oE aln:miun r (ianr I.hc, frruucntt uf tLt• pruP,'r vi`nnt us i., .muitr rr I c6rolr. nu ul> . l Ir. uutput thu.; ul•t...... d lilel.li,1 A 1:w d. nl Iht•, liq, .n Iid) mue IWr: tuLV'PL3 run len;•r di,lntP, 0..1 ,,: \hd)13; ntl. fl•Uehlent can ir, tirlccL•J. I+ta thl/v:rtntorl ap1t.'-'vihrrlim: laVir..ron hr u~od. VOL. 6, f~~o, 17, SeeTrr sEa 17,' 1976 $§:42IAOi Sus<eptihilitYto insecticides of Lasioderma serricorne (I?.I.(Colenptcra: AnoGi)d:ec) grown on vitnntin-=deficicnt= dicts. 5nxena. J. C.: Cluhaiil, HWna IUcp• I'rmI., Univ..l(qan.than, Iaipur, Indial. lrrlr.,/itt., l'kti:.iul. l)iucirim. .. 1976, 8,11U, 5:1-Gi U'ah-0. Normal and sterile adult.cigarutte ,IleetlCs (l.- scrricorne)) rCared (,n whrm:lluwur Ond rilBmin-sulliCient diets were Icss suscrptulNe to pymrthrum and rh/ordamle. 11)1 . 5.-74-91 thnn insects rt•nred on diets defic'icn0 in rihaflbrinI/3-88-r~. pantothenic acid' [,, kf t] inrutnf [87-Y,I:KJ, pyridnxthc [Gi-2:t-f], biurin [:i4 an ,rjl /6)ic acid [49-:30-:tj, na'ulinic acid L59-67-ICI. P-nminahrnzmc acid (I50-13-II)• ur dtiamine' [u'9-Ia-RJI Adultsrearcci in nicufinic ncid-deticient diet were the most'susceptible to both inseclieidvss, - 85: 3G785r Rcmovnl ufnickel carhonyl Erom nir by passing' It tkrrou0h a lrprroC a fihrouschcrrri.orhent•: 'l:khomirrn; V.,A.; geinzerskii„ V. A'.:: Vkd'f• I,. A; \'ulikh, A. L; ICotetskii, V.V.; Vr:rhlnvskii, A, \L; Ixeiq I;. Et.;. liridman, L. 1. (Leninfrad Institute of Textileand Light Inducb "Gipronikel•Scientihr.. H a:urh and 1QCn c1nlu,ututv;. itatrl ntu c-I?(,carctr " Instituterf \,mlerrr uv NIt aisi U S 5'.It. 19S I/'9: ;CI. ROID), 05Jan 1976. Appli 'u29 :1•?. :31. \lap. 1974. F'rum Utkrrtiva, Izobrer•, Prom. Ohrnctsy, '!'ucarnn~r Gnaki, 1976, 5A(1),. 13.. Activated C is the che•misnrbent. 85:$f.47:tf Arauid rlctcrurimdiao nf UOll, . laithuut additinn' of mnrcurir• srJlirlc. Guurn a;rlr, Ilurn; Unpp,II:IJ, ;tiillirim(I I•x•rh. I 1 (', l:n m u 6 f rr.l ./ 1hn . n l7_r . tt FurcrL, I!771, P(I ) 1L'-i 1( rlI,;,.iU. r+ I.a m.r lir rL;inirirs im ('(11).drln r snL>lilul:<lwillr A SUr [IU'!:11 .L::,J lu reducue elw•Irnnmcol pallutiun heIlf. :mu 1 r uhlaim, t... r ropnxluCihlerr[ull'C Wall .M1rir3nd IO.It1P'N:llor Sanlp!r• pt:er tlrC alldll., of rtp;:SOi +}io'()i• thrn. tllr rwxl. rtlluxrd• aud li!rated with, PetNliilrt5U+F2 in prrsenoc uf i'rrruin. - M', 1:. dtirscndhhl 85:.Ia100s hSel:rods nf cntnpulcr-hasrd prnerssingnnd'id.retiftrnlin:rof m:rssspvclra r.fgas,ous psrulp•,is:prndncts of t.ondor.scd substnnres. 1'u,nd~rr. I. A.; 1'ul:unnval Yv. V,: Pmuna. \. A, i'up t(). (.; 1'r Su 1nu v, \((i5.31t1: 1". sh., ALn Ludriir: t NmJrrvi.7S 7r. l:l,5: t('h: 4i, "5-Nf. (f(nss). I`rumRrf:. lir., 6him. 1+,1 Vidtr. \ o. JY39t. 7'itleunh•irrn,lated. 85:d11327y Sucondury'Y ion.mass.poctromctr\•[fursurfncc nnalvsisi. Mcliugli; ,1..\. libnoiis :1t- ]'nwcr l.:di., (;en. Farctr. Cn., Stlfun(l.rdv, N. Y.), .l!rrh uf< !'irummm 'l'brir rij)pl' Sri. TecLnu(L 1'dGo, 1(Ncthods tiurf. Analll'• 223-78 t14iq,). A review with ?U5.rcfs. . t33::111 ) (:.IractunPhrnul.:fromnrluenu.,.trr.nns.F9clrhrr... I)urirl 41,r.,ha11; II n Iu 4rimr 4. (itu IS~uI d qnuurs,.l, 1.. mtd l. ) t'•r. Uil.n TI:; I-I (CI. -.,Imr 107G, 11Sr11:p1 ISI r ul Inl 1/ P Id 1 P I'trnuls m:d nilropL ~u d. nrr n m, 1'In m ron.lr aal8rx hq.Ini~iu:r.rrruhrnzrrnT IIC [:r. -.1J tenirl r.n I r.i,nt: .tc.nrr,al nl I I.n 14,ralio.nt4 h.rt uqunl I r l/~r .u: in I-rail utA 1.11 1 d. '1'hr 1 ri I. 1. sr•rpl. nt li, ~.fa um clluru•ur u:llrr r.h iu I r Ur rlf.. Iru r t pltr•nrd? wu( n 1 phn.r <nnr: LI „16. t„ It Icuth 11 1'hAfr,. xch•nr, u thnir wrsl ~.rn. u rd : dr., hc va.. .Y noilimt of the rnt..ie rrrv~l,;r1 lu rsnh Iho ml;u.•PCrlhn:d,•Yi'xl. Iroln 2:f lo 1:` fnr.npliruncr oTtIL. Iln~ prrlr'rfc,l Gnlu iring 1:1. 'I'ht• Iwn I,IirrSrr nre. sruri..IIc tht, r!inrrrm'.e. m Inuvirv: 'I'..Jurccie 00010003 00 JrJ
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..~~uc...,. ? r+w 11IISTR1ICTS 95: 41R17e' C)ecelnplm`nt:9 toaicity in illr rat rdlerinRCSlinn or gnvage of nrg:mophasphattpt•+tiride.c (l)i.pteres•. Imitlanp during prngnaut•y.t itaplr~. It:. b:.; Kellarn. 8..6.: Ilasemnn,.1•. Ki Ih•ul 1na.uflJ muuru Ilr:dth tirl., Rest41reI1'i'rtnllglt' Itark, N. C• ) l;nrirurr: /4 nlNr (krapr•t!. 1976, . 1II;. 1:1'4 dO (6ng)., 1 p. .NCnrSP1~:SrtG.rrlr -~o I The structural deoelopmcnt.of fetuses was altered when Dipterex[52--GS-G] was administered' hy diet to preenant rats from dhys:6' through 15 of gestation.. Rlajurexlcrnal and skeletal,alteralions occurred afler consumptionuf-0."r'Ior..519 mgjkg/day, unlg minor - skeletal.changes.occurred in:the a7a me/kg'dose group and thee incidmmo of alterations in 6he. )•13 mg/ kg dose: group was nnt significanlivdifferent from that in controls. The malfurmationsfrom the 2' highest doses dictnot result directly from the assucd.. - decrease in fnndconsmr.ed:. Diprerex was.not leratopenic.whenc given fdr the same time span:.once dailyv hy gavoge: eren at.levelkthat produced mnternalilethaGty: lmidan 111. [73E-11-6] wass not teratogenic when similarlv gjvcn... eilher bc diet at eoncns. that resulted in a-I's9 redn. imfoorl.consumptiond orby gtivat;e at dose.levels that resulted.insome maternal lethality. Limitatilm o0 foo:d! consumption to 13-15 4jrat/d'ay from dnvs fi'threueh 15 pP gestation did not cause iucreased: . fetal mortulityor stunl.ing. However, fetnl wt. wasredirced slightly, and the incidence of minor skeletal cltanness wasapprox. 3 to4 times that among fctuses of control dams that werrnut pair-fed. 85: 3357Ga Ilnerpretation of gd:~pcrmeation chromatographic data durinGan amalysis'ofihe molecular-mass n.st.rihueinns oCf polymers. \-i!I:nchik, 1.. 'L.: 14elmi kii, (1. 1:,;. Alekvmdrov.:11f.. L.; Reifmant. L. S. Ilnst. Vy.cokomnl. Siredin.. Ilenin^_rad,.. C1SSR)' 4ASO7v.mn1: cuedrn, Ser. A 187G,. 1014) 91G-'< Qtilss). Gel-permestion chromatograrns nP polYmerss wero considered; ass conforming to type C[ probability functiim of !'earsom andcnlibretimt oC rhrmnatoe colunulss accordinc' to the ist 4 statistical moments of ehrumatpa: peaks wrn sur.;m::ted. Thetlieore data shuwud ;nod:rarcement.with theexptlldata.obtainrde hyy chrnmatog: ofpo;ve!)'rcne [9dU3-53-G] ul' narrow mnl.. wt, distrihution. 8:i:33G?5r Sludica on thagel permrationehronlxt.ngraphy' of~wttter-coluble pniymrrs witFh porous alun:ina.. Sato,. Slinzo; Slat•uumtu• Jhinichirn; Fundu;. Kuji iC'crrt. I;es. Lnh.,, Mitsubishi C'hrllt. In(L,Lld... KaN:rsakl, .lap:lrlr. DNnfirkl Iirr_•Itl.u 1976. 2:d3)t 119--- (Jnp•ln), . Pnruus. zluntiha.. IPoraminar/ (l), a column paekin;; matcrinl which~lras developed byS. rt d t, n>r•d 1 rr r.l pnrmr ltinn oLrrmatrd w'«errsul. l ulvmtra , Ilf'[7'v tlues ut:-LU were obtnuttd in colmmtss packr:d tvth..l. u I partnlts:. Gr 1 ue-meatiun cbr rur ducr,prhir cul,hr.lOCn curars ol pohsicrcne IIiI :md"u"tru¢11:1) standard snmisle •Ir bicen.7he' twu nr in l. pqct qrpruu. p.uallcll cnrvrs m r llrc mul ntL runcc I 104 tul' X 111•, 4.u1't the uppnr extlu Au u linat.w ic.l5 x It/ 'U•dtnns firr IIf while th tt (ur1 wmt 3 v IU`. •1'hudd0,rrnra w u..dut. ln the incrt'ucd t•lutinn vulumr r, 111ahf.ll nmve ba• tplained hv. rhe intcrnetinn hotwrt•rl lll''.M and IL Clrrum:rlr :mnrs uf srcrrul w'ater-snl.. r pnlj•mrrs w• u•,dal 4n'ell. l'ohu.r 1. uf'. 1 hid 6m. d resolving puwnr lu, h tl •till n.ue11S{ [lilll-J2-3]. \IaL.wt. d6ins: uf IInlV/ In S;IIr111S'. , hl.ltn:,[ILA' vulnm'ar::ilr.l linrt nt II st.mdivd .amVlr., u',rc m co,.d in v.r1h lhr rau . t. rdl Sy • .'n.'. w,. :,. ur 1.14 nl. P r h 1 h'acnJ:unidt•,. nwrvrr, ~urrt;t mI nl. dr u t:ln,u-n uuld N,.l br ulrl:tined hccau:.e ot: ilatrucumt Ilrtwecn I:ol} e.er aud Ihe aluurina. V0Lr G, No, 17, SEPTEMBER 17, 1976 85; A238?m Tr:mslxt.ion of luharcnn mowaic .'irus' IINRamd -isnlaliun nf I/re mrsscnCt•r fnr'1'91Ycnnt' Irrolcin. Knau•Innr!„ .luhn; Itunfrr, T,ag; Iiwn,.'I'inl; %imnlrrn. Il:tvid (Ln!r. \1n1. H{ul''., Med. Ite.. Cuunr.• llmthrid!,r, ISirgI.L ('r.llny..bont: Mntl.. Rnntr Hi•rll. ,1lyd: Iai>,. 1711n 1 dr !intneriptiun Truna'. t'ir;d- Genoulr•s)'. ^1J:q tlting)I 'Chc ort:im ItV:\.I'rnm Inharnm musnievirus c:ul Ile Iran.l:dbd in crll free sp>.Irun mmlr f}nm rclicldurylc.or wheat geran, and :dsu i.nadt• living untyltw uflhc frog Xrvlnrm<lnrtr•. In ditr.-cs Ihc muu prudutl. i;1 puly)xplidr wilh n mul nt nf 1111(Ilkl 'I'his rtpn t nl. lr m. I rtiunuf 1 r:. ,r/ the viriun:It:NA, whlth h t. a mr I.wl ol`9. 2 X III' . lurpn.mgly, there: is nn synlhcsis uf ennt protl•in, nnd the 1dP,(Nh) d:rhon pnlypeptidr, whinc currespunds in rrnt^ madee in inl'rnlvd plhtltt cells, doesnut contaiu rithnr n whole ur.a.lmrtral co:uprnti•ilit sequonce:. '['hrse capfs. sliow,thnl lht• ItNA presenl intlte intactt virus does uat nonurallvnel: as a mrssrngerr furr cuatt pmteiul synl:hesinc llowever, planls infi•ctt•d witll uuhact•u mavaic virnx's contain a luwmnl, wt: ItN.1 I'15f1.1101t dnhnnsl that can, be' translated rRir.ientlv inl'n cont prntrio hnlh in, vilrno mtd in' noc\1cs. Thia ltNAis not presentt in uninfi•rled planls• Thus„ lobncsn musair virus eom prolrin is nonnally synthesizedd bvtranslatiim of a Ibww mol, wt., mRNr1 that is made iuside the' infected cell• and not hyv direct translation of the coat't protcin, gt•ne in t:lie virihu fiNA.itself. 85: •130Gns Assessment of tlrr hazard to the public Grom, anti-stn0ic hru.hcs eonlainingpolonion.210 in the?orm of ceramic rnicrospllcres. Il'i•hh:. C:. A. M.; Wilkins, R,..'f.;Pdrixno, A. D. (National Radiological Irrntectiuu. Ilnard,.. H;+rwril/l)itlcntiQxun- Hnnl.). :\'n!L.Kndiirl. l'rol. Buard,.((!: K.l„ [Nrp.[ 11r;, NRI'li }23G, 19 pp. 'I'hee ha::vd of rrePir irl antli.lntlc hrnshes uSnd in industrytu the;:enrral public in. )iu;;land was assessed. The -1"1'u, in the furln of ceramir mierosplit•res• in untistatir hrusiteswas not cum:idered a signifirant fiazard to tile putilic, although the brushh has, been. hmmed frunnlhe pulrlic. m.arket. 85: t32f.,in Ucnof aninhihilotr iu the kinetic'determFnation of Rincoso. withh a centrifugal analyzer hy thee glucoso drhydroptytasc reaction. Lutz: R. A. (lab. Dr.. Otto Lutz A.-G., 1A'itdrrthur,. tip~itz.). Clio• C'lrem: (iFinrron-,in/rm, N: C.1: 19.rf 2°.(fi)', ®?E+I@:ngP Acompetitlve inhl6ilor, •Ic thiocvanalr, w;t> mddrd to tihe a.sa7sgstom for the detn nt'' glucusr•.. 1 bc adtht.uf the in6ibitur improvcd the. Iiueatity of tlie reaction considerably.;, but, the shelFlifh of the reagmtt ia. reduced. 85: •151G~d Crorntation nf drnxvPrtcetosazine and itsG-isomer byU:e brow.ning ro:tction he•t.vet•n fructose and ammtmimn. formnte. 7'suchida, Iiirum:bu; 'fachrb;ina; tihicrn: K azunori;lytamura, azunori; Knrmnn; Uasahi:o. (Nae.:\gric., Kul:r Univ:, 6uhc, Japan). Agric. 1iio1. C'hem.• 19i6,. 921-5 (L•'ng), 1qeNjptnefnclrtonrMrz t'ni `cHwH),CHrON,Pr-H N It•fl•M•.N r •ICnfONI,aCIIrOHi ` 2 (u-nrnfrnru 1^',.f I frrnh drrrrtluftl)-5-fnrrv:hrn--n ,T- 4 rrrlndurl-lr(iflpArnrn./drwlrmfsaziilrU.[Ii.lllfl-I:{-3]atld. 2 (n nrnlirnn~) ,1,! ,irr'rdnr(rnlt(,nMll b 1'n-CnUrrn.~' " t';r frJnln~r~~Nrta))l~rv:nt 11 aorner IIL (.p;S11G-Il)-S] htrve hren i-ul,lyd Irum llir• hrwm:' mi.at. al' u-JYlrofnar. [.r7:.18-r] u:J:.\H., lurnmro1 111 i,9-Y]. J,nrri:dly, 1 wns oblainr t tn t e:,neidrrtl I hr;licirld, lint'.. II' a r. t.-rr,n•d unly in a r'r•ry It ci,IJ. Ih t! nartiun ul u-r,•dlao.• (.~tl-!ID-7J'. nnd. Nllr fnrui t.e: un tht -" ntr:rrv. 1 Faruual was prrvlumucunlv flrnned•, tun r I lh,•.r c mn I tr:. :d:v drpcndeut ,n the tunou. uf IhtsNtir Lrnn u, : ud und r al p•ol liatn r•..ndn/nn.. the yir)dx uf r eumn'J:. :mlounlvd tu u.idp.17'g!e ui [Jir wriz-in:d.stu!ans. 00009997 975
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0 ANNOUNCFAAENTS MERTINGS'AND COURSES MFAC In A/ddLGn:rd Ormhrr,tfnninq.. The .1.,.,riaiim ofOlLri:rli,tu:a,vti~-nl Clremists(AOAC)will Ibhl iI:.GUIIr Annnnl tlr^riae Ort. 151,21, 1!R6 0l the \Inrriml Iintel'. Twin IhirLrs,. B•a+drlncmn, DC. About 1YID Irp:dntoU reiro:iruand rrxvehrra frrrnr. Mvrrnmrnl, indneln-, and'arnr4mir in Knrth Am^ri:a ond P•nral'+' arr ra- W pmlml to ntlr:ull TLey will prc:n•nt npI•mimnldl',. 240 Mpmro on nr,I, trv•hniaun: mrlbmb: and in-. - .tnmremnlioofur annljafa or foods; drupe,.prxti-. ' ridrs, tozmetin, foleneie.m.terinl4heeaedmn rub,Innreqfrede, fcrt8irere, and otlur, ma,erids ro- .' 41M to nzriralture nnd.puWie.hr:dth sod wxlfnrc: . Threeaymp:rwe md2.warkshope are ¢IledWed 'b.lnke.plnre duriup.tbe 1-0ayeouveol!on: - A n-mprimo an Ihe: Camputeritod ACtamated : Rulnrnt Anrdyeie laf/ontory w'ill be held l1i'ednes- -day., fAaulmr 2% 1916. Nike.J:. Deutxh, US. Food nod Drug Adminfetrntiom Wabingbn, DC, bk rhnirmae. Thn. Incux will he on taud'.l npplien. 'lionx Abior lol:irr of dimaaion wilf inclmle .•wlyli,vl luboramy teehniqun snrh u Sau-litplid . drmmatopnrphyend.l:ido-locvnre liquid.chroma• tnplaphy; rue..of compura•ricarirun fnr.dctl•nniningr rirtnry inlakep.tvmlmtrr pra•dirliou of' nutrient mnlrol iuiaod'.profrmin[: eoel eRmli.-eoesr znd qtnqify mntrol.ond 44:dlty. emurm,re (complete s.baldh: primld belon): AFy,nprv3am cn Fomneir F.'ienm uJl be held 'Duexler, Oct: 10. 1950. Rirh.rd. I.. Umndle; Hr:reau of Aholiul, ToFmrro aml Firomm41)cyzrt- aent of'the Trensun: Kanhinaton;71C, u d,a(r: mao. AJoinOBympurium of the &rrivty of CAsmetu Clwmizts and ISt-.AOACwill Iakc plarc on hfon-. dAy. OcL 1S, 19TG. J/rrtio UrCnnhp,. hlalmetrom. CLr+niml Cn., LWdrn, tJ, is rh..itmno. . A/I1G^ i.nyrc fl:mmmnerarlr?• ltbrkrhoy m, dnrtM hy Cnm>a Irvc. of Nrn 11,din, 11-I, nNl hehcid Tum!qy.y erenin¢, Oct. 19. An Automated An:d..is \ForF.liul• nm by Trrl:nimn Industrial fi?'New4 TarrHnwn, N Y, wdbbr lirld 15'edoesLy, er.nlnp, 0e. 20. - Immn/lsrrly brfnre tbe AOAC mretinG; on OeL 16 nnd 17, the -tn:rriran Clmmiiil 8orirly (AC3) will hald e mnrre an "anlrinp PaoLlrmr. with dlalron. Liquid Chrmm,Ilomplly" cnnducled by Du/",m dr• \i.wun k CaC nnd' l.lupd It. gnrdrq. Trdinirnn. Inenunemts Cnrp- Plm. n, pnAilrm.,rimlrA mum¢ ie de. rismrl L,. rhrmi.l- ri14 ezprrir•are inn high- pmunmGplid rlnnmammmla:y, For mRlstration oriu0:nvarinn, wrilr nr r:Jl ]lnparlrnmr of F•du- ~nllmcd -4liritiiw, ,tfh; 1155 1,,11 , ~r Y1P, 1Pe.h, iupon. DC'LYIO:VS (:0!'Fi2-IS6a, The Irn ie. $Itr5bm m rmnIb,v, SttO (ar. Al3 mnnhere, and~ inrhrdn ul,•rthm.k. A m:mp:rinn wRl Lr hrld \thndnc'enine-Odl IS;nI G:pG 1•.ur.tn br fnllnrr,I b?t!u~Ilsrrey lV. \\'ilr,r l.amlart el 7:1G p.m..l4nlrrlvinmrnt wdP luyw 'idn,l I.r Thr l.nmr UNlhenx in.n :Ima- ral trdmn tn tl,oPS,L.TI:ri:irl:brhr uf Ihebme yllrl xill hn Ihrprr.rwalinn nf1Lr.{tiilrv Aw-a'. In \Tnlhr'A. Irou.•, J6„>.mlh.rn Cr¢Lmal Ilb. rnnJr Lahnnlurin, OS'. I?ry:.rluonr nf Aerieul-brr,, for bie urieiual r.warcb an m.Tl'^I eM dfnbain: Nr•erlr. 40 Sru:r odl rsLibit.ll.:- Inu,t Inbarnmrv nprlpn,na nnd nn.lAu+. Ibeial:num wdl [;4r. phirr fmm 1 p.rn..<nnd:ry, (I,r. 1: Ihrvneb l'hmr day memmq (All al: I:r uualumi/. rr l: L.r ope,Lprr EI0/,n J:• -.li,r.J!1 iM•vr:o-d p.a..n• rm inritl.d lo.aurnd' h„r fnnbr :uf.nnm- tino , mevr I•nr9:r /t: 1'.u:anur+.r; Ju.IC. IL,.M0. Ilrnlnnnn FJ.v,klmnlnb..n. lYmMlmtnn. DC. 111011- VOL, 6, N0, 17, SEPTEMBER 17, 1976' ,1feHlnrts and i., mpo.ih The:lnlemetlnnnl l'uiun ofPnrr and Applird Chemistry(ICI•AC) l:ar-sdmduled ttc fnllo.nq meelinK. fdr197G nnd 197: IUPAC-1U4iQ4TSynqnatum. an A'r!renrrs in 8lnnkinn of Fdods-14'.imw; Pulan:t-9ePlenncer &10, 19 0 lIf' Intetoatiannl. gymPSSium on hfycamdar in FoodatuQs-Paria, Fnoee-SCplembcr 16-1d;. 3070 .. Bympoaum on Clinical Chemietry end Chemical Toxieoloey of Toxir. \letnl.-hfoutr. Carltr, hloneco-\Iarrh 3-.i, 1977 Intermtional Sympnairm on hlicrnehnmiral Tech- . oitluee-Uavae, Fwitzerlnnd-\lay Zl-:T, 19)7' ' Foriurtln•r infarmntiirn on the meelinn,.wrilu: 'ILRAC, Iiank Conrt Chamben, 2-3 Puund'R's.., Cndry Ceulre, Oaford OX1 35'$ UK. The Intemntion.l OTanirntion fnr8tandardire- liom (ISO)) hea sheduled lhe: follawinC mectrup, in 1976: 8pites and Condimcnu. TC 3f/SC.7-Ceners- - Seplcmher 68 Tn, TC'.31,'3O.8-(lcnera: Srptrmbrr9-10 Milk I:nd \IIIk produrt; TC 3i/aC!5-Berlin- Qh Qprzler (Datee tobc ennuanced) nnvcmber 8.12 ... FL•o-dsy uorAshop an the lun9 anA thr ar.vimnnu:nl. 5ponsorN tly Tho JahnS Ilo.llkins. Onireni/y Sc4oulaf llrirse anJ I le:d14: II :INmorq h10: Crnlut .t Dt.. V. l.i lY(:mp, A"I[ialo Dirro lor /orC'unannin^ };luselion,'Ifie Jallms, llnpklm Cmra.-ly Sel.oal af Ilyi++rc. ::nd I'nblic. Ilc+liA. Fro:n IUi!{, 61f \. 1V6Ve Si., F:doimorr, 311) 21IU5 U01) 955- 3961..ho fee.publishrJ. 00010024 1002 k., J
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~3 ,,`?, ""''~"~"° I-CAak,y'~' ~ ~~~,.., .~""fEr~~~' ~ c:~ - 71B3TRIjCTS' 85:.d1G12j Sepnr'alinmof Nrhetcropolycyc3ic aromatic hy= droearlmns frnm poCycy'c'honnnnatic hydrocnrhons. T;cparation, L)'.complesy chronultngntphy. Kliir,isch; 11.. J; Fux., Ii. (F'orschungsinsl.. Cigarettenind. e.V:, 1lamburg, Ger,). J: Chrumofngr. 197fi, 1'2012), 489'4 (Ger)+Acidic and basic. ~ t 11 N°contg;, heteltrpolucyclic arum. hydrocarbons (aza PAH) weresepde from polvcyotic amm. hydrocarbons (l'AH') . Ly' chrbunadrz on cvlumv of AgNO.rimpre.naled silica gel. The compds. weree dis:nd.md' in. 1% R1eCN', in n-CsHtr and placed onn the calLntn.. Gininn.u•ilh the same solvent eluted the I'A71 but not.thu aza, PAFI, which formed complexes nn Ilrecnlumn but cuulitd bee eluled suLsequentlyv as a group with ClteCll. ' By this methnd,., the.l'AH anthrurrnr [1:'.0-1'2-7], hcnznln[pvrene (1) [li0-a2'-8] pt•rrfcnv [19N'-55-0]• and t•urnnena• 1191-I17-I ] weresrpd. as a. rnuP from the az•1 3'AFl ncridinr (It) [2G0 91 4], ncritipne' ~9^--RI-9]', curbn¢tdr. [RG-71-tbL, ! ^-hunzncridme [22.5-1'1-6].. 1._+s,6-rGhrnzcarbo,ulF [207-8:1-I], and dibenzola,h/nrridine[C!G_aG-8]. . Ni: A31'!7u Iiiuloeic:d applit•nUonslofscarcninF.s elecnronn micru.eupyl: smnple prcpxraliirn nnd qunnl itati~nn. Cnlcmnn, •lltlna.. It. INcdl Cenll, 4hivm l1'uchcslvr, liurhn.vlt•q. N. S.F. YrnrlL •ti'rannutl•'-6/r•cfrun bfirrnec.:!1J7fi, d91-:i!7' (1•:ugl~, liditvd In• Guldarin, •firseplr I.; Yakuwilz,. Ilurvcy, 1'll:num: New Yrrrk, Ni,Y. A revicw with 611 rcfs,. . G••57077m: (,.a;-ltqmd 'nG.IcIS.m .Ir•ynpha dsnV!!licstinml totSestudy. of ch(nlenl oil. I)i 1,rrcm: \nl.... .r I,tt r-rti;. Arnnltlo: SitlnP~ri; &r6rrlo llnsl.i (.hetn. An'd., iiitiv: 1tuua, I'un:e, Italv). Atln- Cnno. Nac.rJlii FS-~rnc; 5ur 17rrir. :1cr:tm: 1975, 6-7, 3-19'(! al'. t7«+ 'nl rltl chr urate nf n acrsl O^cnr•t„ trrpenes n.+c ad rrrod nul t im t criunm 1' -ed ritiih graphiledCbhtckmr.tLlicdxrth0 ir r r;-SI'-Illal nILn6 ti iliu:; palymcr cnnt/6 acidit tumttr,n;J t,t mp.: HUtulu n liint+ urc gia•cn, witich' n•r.rce marketlly. ddirrcal Irnm th ru r hlainrd hv 'stnrllar'gas-Iiq- chrarn:do!;h utnChrt•:wsnrlr W ptu. 37c 51'-IU:RI, G+t~ -solid cllrt mztt . 7~ b1m' Lt71U~.?~luwm l 4.1.C, laccmrp,rnnut of gcaphited CC binrkIrlu many of which cuuld I:rirlcnti6,d. An:d. ti:ncv tterc imotcncd bythe. uxc of 11 in1tcnd uf N as a!arrfcr gns. 'Che tltcory uf gss-liq.-solidcLronmtur;. is.discusecrL. 85: SI51^-s Effects (if eytochrnmr P'AIF'.utdr Jill intLtcvrs nn micrnnumFil drmcl~hyhtilrnvttnihc dt•.mtth,lt+c cctl.ily.. nnd lhe txp.lcitynf I"aFAnd uurru.nmrs:in acl •.alr utm;:= thyJntUO.alnutrtlo n.nrulqltu l unurplm I Ll , I'luttreµ F• Garrn..C..1. ( lt Sinai Sclt \l,d (ib I m+ ^tw c6, Ncw 1 ork. N. S.) . Slrrrnr: lA. . 1 1(,, :~'1 I! 1: . 1!: v.). rYn phrn bnrbrrn!' ( u Ill-7]..J nurnvrciro7nnlhrr'n :Ind :Ic0ur IY.r! [11(44~-hJ: 11 in r..isrlhIrallrthr irliai.s uflivrr ntiao<urrud dirmlHslmlru.vnnnrrr •l,•mrf/et unr ('111,3,-:fl-.I I in C5: m',cr and' t/u.utpauilr uf Ihnnticru, nm, lu...ai.atr di/nrbta'iu rr.rumr. (h! i3 9] In t inul :rn •liud,u uulurlinn LVy pht n d•t,bn.d u r- tli+4. nt IIIIA/-nliorv. lmf a r n i.n w:m a h~ss rft..tlre. indurer m this.=tt:lin Ih:m rn Ilx..(:, u,i, . anal me:dni.liul:mlhrcur e:rs fmnplatrl¢ im~l'tvetiar. Ilalh,di:u~•.thvl= mtrn.:uniu:~ JrrurllirlLtiun nnti nuot:r!:onr.is arrrn.- nrhihilyd 6vlhe•.':rddnv ut ~I(I`i_,i :\ ur Len.•ul,tllrcrrnv tn,llhe 1,•arlruu ntixls: VOL. 6, RIo, 17, SePT Fr mER 17, ].S7u' 8fn 43287w A' new method fnr sitnullanenus deterntination of a rrducing, end group and cmnpunenl hexoses in olirto=. 6auclrarfdes hy t:as chromalui:r:qNtv-m:tss speclroscopy. Karnei, Akirn; Ym:hi::umi. \ka.hi, Shuzn; KuKahe, I(oshiro (Fac. Ph:trm., hlciioUniv, Na;;tm'n, JapanL Chem. - Plmrnt. Uu1f•' 076. 24(5), )i103-1U (F:np). Simulcanctas detn. of a reducinl;end hcvose and tlir nmLu relins u1 cumpnnent, hexoses of -troli:;us1ccH r ido (rnnt m•Innosc hc sc, and (nr)) galurloac) cut Ite achli.vrd liv m. IruSmrnlt wrthi gas rhrnmala„mrx speclnutrpy'(t,C..,s). in. amjun.tinniaidt a multiple-iun dehrctor. In thk procoduro;.l...raw-1 na:idicr,accharidc was rractud wi!n NaIY•Ht in =NfnU lirr 2 hr in a ar:datl ttlhc. and excecc N;dlait v;a, tii•strosed By aridn..r[Uowes 1-\S. Ucut[rariun. a;ts Aftcr In'dmh',ii• rcdn. be i:nl4ar, and t•illirucoucctvlation.. the .amplr w;n aMhzed bv GC-\15. Hcducing-cnd hexosc xn; identifiru hy, dcp;, the r:nius ufpcak hci_hts at rnte li-IBand,Gt6; the rnultmratiln ot' fhae contpnncat 6exoses were dctdi by comparingpeak hci;thlswith calihrulion curves ot'stds. ' h5::lti7lr.p 1•.misaiun ,tu.ll.absurfniun of IiRht... Fundamentals of utbtnrtc aL,orplinn spcctrumclry, tihimnr.o, .Ytitsuyushi (Fne. fimt., Toktn ffciv:. lcric. T'eduml., 1(oc.Pn,i, Jnjmn). L'tu¢,M b:rr:lq•u17ia, 2a151, Y55-71 (•fapanl. A reeicwwitlt12 refs,.. ' S.'lSuno-a 85:1G97Ru lsiquid.d chrnmatographic analysis in wnter pollutitm'. Suact• lnrin H.; 5ow4n<ki..P..:1ward J! . tlicp. Cllem. ' F:nviron. Eng. Sci., flrexcl l'iniv:.. Philhdelphiai ha.h. Cilnimntogr. .fnnl: 6no;rnn... L^i7. 4"1-b3 It'.ncl.. ii,'ited Ly Groh. Roht•rtl.. Uekher: Ncw. Yr:rk, •"1.. Y". The cnve:s aie useuf lijchrnnmme. as:n cnffectinn.melhod mtd n, a sepn, mrthoo.andd the s}'fll`llt,bc fl:iJ;.ilic+.lrnn ot urg,Inti~S. Infiiluinl! In:::romuf.- org. au,.ls: IipidF. :naiuzs.:uninn rsid:, I:ePlida=_..protchu,.Cn¢vmr•s, c.vi'~olicdtlle Lu h. ul ! r tres, lu ^~,:ulfol•m nrls pusticiJes. pnla'.hLrinnleI'hi.r.,~n t .hrtcolenn: pru:iuas,pttyc.)'t•iich)'dro= carLnns. nhntal.,,~nti darvria•uts. L;ir iitls. 8itJ•iJrflh PrncvsceunlrolLyrnmpuler'-armriew;.llallirld. J M. Ili+h.•r I'rotr: Ifquip. 1 d!. 1liiidlnue`llenl', 1•:utl.l. Clrrm. f ny U.anrlonl 1J. f, "fl-t 1-1-1 IFin.l . A reclraa,.cilh 28 rcft 'I'he oPPli.tums :rnd bt•nr!lls nf campineruuntrul ul' ehc•m: I:roresses are drsrribreL 1c la•wmetLud§. ui tnmpuLo conlrul (e.g.. npon and rlu.edi lut,p: ennlrol, styw•nti:d or un-oaf contrall„data ecqui.,iliun, rtc are disct.=-sed. 85: tl'./Gln 9umr prulrlrms of', flamr.lt•ss rnrthuds fu alnmic rtlisorptfon sprctrusrnpc. 'foda.>huru: Unkn~s, 1'uk:ko ID.p. Agrir. ('Letn., lltii•. 'I'„kpu. .fapun/. Dunk„~lG~rd;1'n /!175, '?JU), I:iq LCt 61:rpmt. Acrrie•.rv:illr f.i rrlt S. Fujirda f 85:~4?9aSR 'twlptolirri:rcnlardirleroir~nt,vludibs. Jf. Clffurn unutl.c: L:•:Idrnrrl'orl'-f111lpprLemcrnvironment.. frmn ut.tl:m 11, rirt ulzr dicLrr e+in slnrlt~r sr qy .. U.rn ..on• lolm it:add rurh I lSinr.. 6 IPntL, (.u,•niL,~r,. f.iirdrq. Rnberl I,: Riinn,nl rt I:,Iltttrrl' Ui rl>si, t'.rC ('Li~utc, It ,har7; I I n q I.. I' I1Y p('ham ~t nliird l'nit'.. Sur tnrd.. Crh1.1. 1' •t,e t'ln•rr .1rc19r1 1.11_I:IU i 1110 rqwt~Jtu~ ( Ili Itun-tnrinnnu•m, ot 1 u,:f• I('I:)1'I l alurl-mnt 1' r:dl.in llrir uxldv.d 11'~.I~~rruaiilm.r nn :utd ndurrd I 1(/'alrlt- u:r. Iqn, durwlrnlctl talh (A1FI11 tttr :u,.nf /'ll 1 p) lh. reihr,~d..tutc+ nl Ihr •q I,uu tcrrr ludii•d ;n I I.~ r! !,r v ucrr.rll rrM-mWw r~Inir n„I tho Inl:mg a v t.,pu,.dr~u, r n n:L.mucr.. I'rt•nuus. \ha ).:udivs uu rrldL.~d hr h..l~.iu ~utd ev.durrJ +('ll I'..I:,uIrr.c intp:inrtl d Ihr prr "tn r cf .in sci.ri' ILi.dati• ii,:.md. '17i••rrG,u~. c„ntr.lrcln Iltr cnnclu.i,acm.i,-Lni li..ru prrt-i.~twrho.lm slurirr. nn i 1'U. Il.l. tMan:lntlc th.n 1''I'Il,tl.u h:r. a IlVinl.nr• hqund. 00010001 979
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ABSTRACTS &n419"-5J Mclairoliles:of;Fphrnvl-5-methrl-I,°:f-otadiaxolc(I'DSOI in rals. dogs, and mice. ScbiPkedantz, Paul: . ll•; Sk!6danuwxki, Mart9ia, A.; Zaletel. John; Starmor, Rohert. S.; htinnemeyer, HarryJ.. (Lnrillard Res. Cent., Crecnsboro;N. C:).r J: Agric. Pood Chem.f97G, 24(4), 876-81 (F.ng).. M s & ' nr~ (/Fa." ''' . . Dlttabnlitts oC3-pheny!-5-mefkyl-1Z4-oradiazole.(I) [I198-98-1], , a potential tobacco additive.. wereisolated, from the physiol. fluids of rats,.dogs,.and mice afteroral Il administration. I.was met9bolizedby hydroxylnlion at the Para Ph and the Me R osilions. Also, the 1tepositronwas.the site oC attachmento['-acelylcysteine Ind'orm the.mercapturic.acid dEriv., [59aG7-49-3].. Urine contained the glueuronide and sulfate conjugates of thehvdtoxylated materials in addn.. too the h7drdxylated' materialstfremselves. The mercapturicc acid glutathionyl precursor 159.567_(7-41 .-as the major metaholite in ran hile:. Metaholitesof1-5-"C were distributed' in the rat as follows: urine, 4870; feces. 23%; C02 inhreath, 13%; intestines, 3%; and other body tissues, 5% of thee original PASO dose. 85.427GSs Purificalion and charnctcrizalinnof a.sugar-= unspecifie mrch•n.r fronv tobacco strnpension cullures. JBnski, Alviit M. lNurth D.rkuta.Stale l:niv„ I-l N. Uak.l. 1975. 1'!8S pp. (1•:ngl: Acnik \crux, llnic. llirrulihus• Ann Arboq Mirh:, Order Nu. 76 I:I,,5pi. Frum.!)iax: Afaefr. fnf. ft 1946. :IGp13. I'1. 11,lR Y8: , . Ynsushi: ICuni+hi,. B8:4'LYI''> <".nl'.lus mducer. Alascui, Susumu 1u„anumn 1 in: r, 11in~mi ,Ivn sbl (\i uuzrn Od' Cu,. l..r:.) /:Pan..Knku rfM15,t71 ((I(.jS1i:111M)1 .alarl9iG, wesrlprcq~dUndth•2 hlc-tdp iudrIcaccuc.nudll(l)'ornclLdL:trIuui~dao1C For exnmple; Nirntimml fubat•um mtd t/r.e:n anfinnwere a0turrd an thr (.insmniorrSk,Hrpls.medium nddrd aitllI nt.10 r; I() 4, 10 s, anrl IO+tbi. No cnllu. n'as pnKlucrd' Gnrn O. snficn, whrrens. t•nlius of' /V, trrbooum w:res pruduoe+l in the hns adNrdd with 10 t-i(1'':SF 1.liolh callusrx.,uf M'icutieom nud On:a wcree prnducednn litrmediitm contg. indule-:!-aeclic ncid'nr'S chlorophenoxyacetic aeiil. Y.. Nunnkutt•a 85: d6_01z Acylphenoxypropanesulfonic acid sw.eetcningnFCnts. Farkas, Lurand; Nogrudi, niiiraly; 1't7leRe1, 'podor•.. Antus, Santlur; Cutuecen, A/;nes (Chuwin Gvrn;yszer es. Vr/•veswi 'I'crmekrk Cyurafit.) Ilung. '1'cljesIO"j[H (CI., COiC), 29Dec 1075,. Appf. I,:1:8i 19 Feb 197.1; 23 ppr, 4atcHl Ut aC+ II II 1 f. n-natSleHrh ont 11,.. a=H (Acylphennxv)prupanesulfonic acitisI(Rtl = hte• F:t;:1:0 group in 4_.or o puvutnJ and.,dts t\,i, IC N11dlwcrt prt.pd. I:yredn:.of the rurn pt.:diuH ah•dlont•.s (hmmv• llll4-prutttbitg nroups),.u[ by rratui.n,a.lt tvrih pn.panv.ultr nc. tll9)'.ur 3' hvr prup:mt^ndlunic. acid orr vahs. Cumpns. eont ~. u;Ul-Ilii.rtaL I wore swect Gt,~ sitie tastcr. 'flur.. ;'.;1-Illlqil,if>C(J61e in aq. N+Je(:Oslsl . lorntAl IH at U°.'I'ho-mixl..u•as stirrrd 2 hr nt u" n:td 15 minn at I('o°nnd then aciditit•d to l:ive 7C'io thr Na snlt uf' 'L;) tll(DI11(1„~It'f!:Ia1Wr.l1L•CU}Ic. Cnndrn.:rtinn uf: the httlvr urrtulriirn.nir tirriv:.aitlr i>avaniitiu in.ti\' \idlH d8.hr,il :9°' 1-av.e ti2'~ th corrc, p mdm;; t I:ar nr )vasail t-m It m c:rtalylic hydrut,t.n nim I:ave C. vU;o 1.1H. -\ir, ttd'.iu 4. ll urLnul. '1'. %ttllllrcll VOLt, 6, 110. 17, SEPTEMBER 17, 1976 • 85: •If•OG3f tl-IIcoxv-13•l1-dihvdroprnstnElandin-9:-ketuls• Schauh, Ifobert. E.; Fihyd, Middleton H., Jr.; N'ciss, Martin Joseph (American Cyanamitl Co.) U.~i, 3;932„163 (Ch 260-~340-7;.C07U), 13 Jan 19:fi, Appl. 475.479. 03 Jun 1874;43 PP:~ Fourtcenn titiee compds.. I(It. = 11; 61c; R: = IIE, rlq. Z= CHi bCOrN H:cwcntar. 2' OCH2CHc0, OCH6IcCH:O, OCH:Ctl .OCI4:CHvS, O(C)iz):A, O(CIiMeL0. OCH(C'11.C9CHiO!. SCHtCH:y), useful as bronchodilators and ast:astric acid-seeretion inhibitors, were prepd. from mixed Me and Rl'2-a•pcinpcntanonecarbnxylates by etd. reactions; -70precursors and anaiugouss compds.. were also . prond, 85:.45480c ComParativeevaluationorlhe.timih>offertilizer applications to tobacco on soils of the liuhan piedmont.. Alekhin; S. N. (Vses. Nauchnn-Issled. Inst. 'l:,b. Slakhorki,.. ICrnsnndar, USSR). A,ro/:himiya 1976. (I), ^':-8 (Hu.cs).. N cunrpact chernurem, dark-{;rac fhresOsteppe; and brown-forestloanrv sanrJvsoils, aplit zI1Pl:crainn af fi.'rtillcors had uu advantape overonce applierl ti-}'-li mtes(IiO:;•/1;111.31:yjhz)„ Ott theIst 2 saill lvpt•s apidirxliarr uC/ P16 duriny nutu:nrt plowinG antl of N dttdu; sprina culti..:tiunr.avr thchest rrsuhsand'.un the hrnwn-furc.t soil apphratiou nf' all 3 elements during spring cultikl thc soil was preicrablc• 8R, 1'!1.19r in t•itro nvsnoinlinn u( T\I1' il.'\ (rngmrnts ' wilh,•I I.l lrurniu ('ui1y.II f ntrd.C I n:ru..IJ.1•..:. IIir11,, I con (I 1ib. 1 im " Ins9t Ili I\Ld Crllu un. tiI'rash-,urg, Tr:m<tnplinn I/r:rnsl. lu;J li/u<m•r:l, 19fi~r`(1:1 til•'uc)./'4 r ~irw virns wilh Inrcfs,.mt Ihv protcin-li[~rl inta.ractinn ol' luhacen mosaic ('I'FiV). 85: 4•i1Gdc '1'hu strucfure-Instc telaliuus oC.aslrartvl.dipeptidc. esters. Arivu,lti, 1'asuo: (Cent. Res, Lab., Ajin.:n;utu Cu., Inc.,.. Kawasaki, .In)mn). :1;lriel liioL. ('ht•m. 1076, 983-92(1?ng), '1'hc ntol. features rommon to sweet'-tasting dipepfidc Corn at, - H.i.Hnr ' .. cc r . NH t. n'~X.ar=,rmlr nYd•°p°C41° uCS111unVl,al~ Nr..caHr LaQe hvarun>•on:< ruuettr°.nt ' Pr 11, nr=fnoll nro.r°pnoelc a°lt111u.°rp rrrlrny~nLic.luCfrulu.nr.nr~N esters nrne descrihed', The mrd. frmares ofzwoet'f arnino aeidss were rcwrcrnncd bv Ihe Gis.hrr prnjvctii.n fl+rmul:u nnd swect )rlidrs utirrcl:ur ra the vwtt.t .mrinoo ati I Ihruugh Vtbr •rhrr prnp•rlii,n tLrnmlaa oC. tlr. {aPtidrs. 11 wus ounclird(d lhnf n pr•ptiJe is mw'ei whrn it t:tkts the firrruula 1, whcrvss when it t:,kes Ihe lunnula II1 it is unt .wrrl.. It wns uiso rnnrlhdcd thut a atllhir.dhr;~ sltr titi in 1..1 Losidr> Ilrt PnsndLlrJ Al1-1)sy+trm in n•a.cet mul. is nrressan• lirr un irnense su•retne<l pi,tinry. 11hr. Inriuun utl Il:e sitr in Iln• mul. relutivc to the AI4 It srst,•nt i. irnpunain„u.. well as Llir sIl:,pp nnd: sizc of this sdIln:nis Iho :tirl I iu ling siti:- t rn.ulcretF tu pnrtriipalr rn bsdrupll :bii iurrcnrt.... tsith n niniil tr h;nd'.ing site Itrt tflP t'6[/• terepli:r. I11, rt^.0.tat 'N'CeUtl'18 is uh.•d. u•ht•n these ret,uirenlr nl, nre .n t,a ied. 00009995 973
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~my~~~~~~~'~~ Yfc,n,.~ 1 B B ~.`N3Y 6./ ABSTRACTS 8•5:43718g Prepxration and properties of partially.puri0icd ptthnona:ry eYlochrome. p-4500 fromi rahhtts \rinc, 1•imc.[: Philpnt„ Richard \I. (Nall. In i, 1{rrvirun.. He dth Sci., Nal[. Inst Health, Itesoarch: Trinn; le Park, N.. C.). J. Sful. Chcm- 197fi, 251(11)., J'-'iY-•?0 .(F:ug).Cy'tnchrome 1" •lir0: 1111 frum rabbit pulmonary microsomes rvas purificd: -02-fold. The purifn. method invulved solubilirnion,. of microsomes' usingNa. cholate and recovery of I in:the ppi- fcrmcd benveen 25: to42°ksaln: of the digestedd microsomes uith: (NI I._1,S04 in thua abarnce - ofFlycerol. Further purif»,was achieved by.chrnmaln;y nn DIsAE-cellulnse and hydroxylapatite. Partialih purified. prepns: enntg. <7.4 nmoles of IjmF of prntein were essentially free of. NADPH~cytOChrome c reductaseactivityandcylochrume bsandP' 420. However, epoxide hedrasec was copurdied'wirh. I. 17:e CO-difference speetrum ut tiithionite-reduced purified' 1 showed theexpecled'e peak at 4•i0 nm. Hhwe'er, the magmiude of: . the peak was' dependent on added microsumallirnd liaction in the assay medium. Pitrified'pulmmnary I formed lypical lypes I and 11 subslrate difference.spectra with benzphetamine antf pyridine, resp. Na.dodecyl sulfale-fel electrophtrresisof partia!lypuritied I Kavc?major handswhen'slained with Cuumassie.litue.. '1•he faster mm'ing.hand'which contained peroxidase activilg, had an esid. mol. wts of 49.000. 'fhe I fr.rctrun,, when cornhined'wilh soluhilized pulmonary microsomal r9rlDPli-cylnchromec.redUctase and lipid fractions,wacactive in lhe O~decthylatiun of 7-t•,th= oxrcamnarirnand the N-demethy9ntiun of henzphetmnine. 85: 4:5012b'. Thc dt•tuvmiuation ofdichlirrvos in milk byy using classical and' squarc-wave pnlarocraphr, llavidek, diri; Seiferp. Josef; Dnleznluca,. %e!era (Puc. l:'ond •I',.:hnal., Praguehtst..Cben.'1•echnui., Pr;Pre, Caech:), 3filc.rrtcixscrn~cha/t 1076, 31(L), 267 -70 (F:in;): The indimct pol:uor, E mc•lhud 1br the dctn. of dichlnrt•ns [02-73-71Lwas:npplied lu miilcsamplr•s: :.tilk wrs purified nn a cn[wnn n19 sdlrt eeli and.d quriwxaline I~uunm[d nfter nik. h}drolyai: of dichlarvos snd suhsc quert amdr t.+.Gen with o-phcnyluntdi tmine. wa detd• by cl.rs rcal a,1111 h•r)i sq-uale polaror. l t t thea elar r.,tl mctlrudi ti e. u nvv w'orx 0.15 ppm, rclalicc demtien and rtcncry ere'o.. liv sqe wave pn!am;. it waspossih/e to dct. 0.2 vK'-dichlurva;.iit to nillsoln; and in a~purified milk sample a quantity cmreapoudiug to-0.I ppnt dichlorvns: -85:d1fl0''u. Evidence for the Intolsunenl of cxtochrome. P-fuO m tednctiiurof htneulalptrulz l.5-oxrdc by rral.lirrr microsmncs,. Knto„It,l lu.walu.h• Pubraga, I.,\yurhi.H'.. (hiuji>atcxltes. Lrtb., Idu,liau•n i'hann. Co. Lid., O>:tkn• Inpsnl. 1Luchcrn• Ilioplqa. Res• Commtur. 197G, i0(3L 6y1-7 (15ng). ~.. 0 / Unn;n[plpve.nc 4.i nnde (I) [1rW'1-/7-3] ttt, rcduredl tobtn:u(alPvr rn• [111 2 bJ iu utr r I r rat littr nu .rn,umv9. irl thc• prt ".uttul •\.-Illl If [7.{-.u b]. NunrncvuncnrhtC by Lnilyd nu......... rrc. wr' utplr;:il lt• Itedn,1 wnn, rrot nhsd: in1 mi..ruaonue ti'om nrxhunt I:rt.litrr.. n:hi,h hate lou r.^nr)irum.r 1' 1.5(/ [rJU4' I'll r ut.nt<, uud thrv rrdn. rate intn'crtl tcithL n8r•. Ih r rhi. ..-r dierta.cd Int'U.. bul ' mrn r.rd. hp ph.nulrxrh.t:d :md :, mcthcldndnnlhmuc, whu.h nhu iucrvused tllu rvtnrhrmne I' Iol) eunl'.rnc 131\ an] mr l:ylcinln,.en •:timulr4d I r,,br, Lul the Um dLniuu waa 'Ih li.hrd' Lv C11. Ilimrtb~l.aoilinc A' uxidr•, ttur.mudr N -oside:l cu:d aumene LeJFuprroxr.L:. nlurh intrr.trl 'suh rcducrd c'au,:iirnmo 1" Gb11, drrcc:ncd' I rrdn., :m,I51<F :t_.', A:.IimnLuNd ii. 'ti.r:r rr'ults. su;;I;rnP ILat I rr,ln: L..cs1•tl1'scd Lhrun;;!t Ihc n.dur:d lurm u(: r?t.rhrume I' 1 .11. . VaLr G, 1 do r 1•7, SEPTcIDeR 17, L'7u 8s42:(f1r1 Side chun'hrd'roxvlations in' bto.ynthesis of chulic au1 'Phe ' anrl '!6-lltalrovylalion of i,i-choles= tune-1, 7. I2ir-Iriol bv. rvrranstttulr.d systunts front rat liver microsumes. lijorkhem, In; em:tr• llaniclsson• Henm 1Sikval[. Kjt91''(Uep. Clbt. Ohem.•. lluddin tli .p., Hud ifn e. Swcd..). J. fJinf. Cliem. 197G251(1I), :I { r ) (Kng):. Hydr xylatinmin the25tir and '!Gth position of S~t-rholo-l:me-fln,;n,l"n-tnoi. was studied nnh reronslrtuted evstem.s trunt rat liver mirrosnmes ennsisting of partmllypurified a)9r,t1 romel' 450. K:\I11'lIn'tn= chrome 1 150 reducta e vphruphnlipid. and anh \UL I-1-;:enerat.ing svstem. Nir sitle-charn hcdrocvlsbnnwas nbsd_ wren rvtnrhrume l; 450'uas mnitled. 1\ Ith.(\11:J S0: fractianated c}fuchrnme. P 430, ?5-and 21i-lq'drux>'Intion was slimulated S- tu-8-fuld by addn'. of Nr\Dl'li-cglocflrume.P4511 reductuse. N1 itlrsuhtilisin-= treated cvtochrome P 150 nn alhtosl abs: requiremen0 for N AIJRH-cylochronteP 450 reducti e was oblid. Omissiom of lipid'did.not reduco-.the rate of h>drocylhtiorr.. Centnf•rGatinmof the cytochrome P 450 prepn..at 1000:0 X p,for 1 hr just bcinre incuhation markedlyd tncreased lip,ddependency., A signitieant differe•.ncee between 25- and 21i-hvdrox9'lalion w•asobsds nllh respect to.sub trate.satn: 1•he.stimu!amry etfect nfphenobarbiial treatmeur.on >5-M.drox4lation.ann tFeihhihitory ef:'c•cn uf t.his . trealtrnenton 2ti:-hvdroxplatimnwereassncde with IEe cvtorhrome P.5I1 tnction: The use:of increasing amts. o Na chulhte in the soluhilizatibn of cptochrome P 4irOiresulted in.a Fradua[ decrease of2u-hpdroxylase nctivitrand agraduaiincrease of2fi-hcdrnxylase activilv. '1•he. 22 h.d'rosylase activities were scpel. p=rtia6 by chrmmmlng: nf' subtilisin-trented cytochrnme P 4F0 tracliun' on DE.1F: rellulosc:. '1•he questinn ol' whenher rtiffercnt snecies of cctuchrumc: P 4u(1 are involved in 25- and 26' hpdruxy'ihtinni is discussed... . . 85: 4 I5G2h AIetabolirinteraction.s in industrial toxicaiogy: enzymr inducliun and mliibition. Gotti; \1. Brirhenli, F. (Ist. t\lcd. I,nv., lbrrv: Pndaso, Padora. lt~lv) dfnd. 6ao. C97G, 6r(11, Ii(1 tlttl). Areview tcithS7ru- nftlte.melabe and tnelabuhc iiurr-•tctruns of carin 1. Icpesof toxic sub,lances(f?exlfoidev, solvcnts, metals„ arum I:vdrocarL•ons,, dru);s, etc.)') wlthh respect p> theinductiort arrdl inhibition uff euzymes, esp. liver micrnsomaf cuzymus. 85: tOR69h Dcpresninn oi thc htrpatnc cptochrornc P'-7i0 monn-o ttcn•lsc sy ttncbvadnrrmtercd Irlarrne 12.7-bis= '2-(diethvluui.nulethn q.~iluun n J-onc drhtdrachloridcl. ltenlmt, 1i..1ti: klcmmlm^• Giihrlt.J. ICnll. \I.•d:.JCi.. Univ. Ii:inn;sota. Ititinneapuiis. llinu.l. llrn¢' Sfntab Ui.pux. 19'rG. 4(3),.223-51 (lmg), 'I•he oral administration off the antiviral ElrNCNrcMr.a cdnCNrNtrr ~ 1 nLcnt filorr nr HC1. (1) [27> H G9 1]( r0 m~/iat f rr 1 datc) to rats cau cd Ir tni hepltic micn m d erliy)rn rplrrrrc A(le= mc(ltvln r[ tll 74-1) feo Qhh..r m ncdrnc~lu c[rRA-.ir=9J and mriLnt )r.6rur1 [.11117-vu lll lclivilri of tt I1 .rnd 2' e,.rc:p \!itrr~nonrd I al uf n't'rh mrV 1't1' (0tt45-JI-2[ nndiN>i/l!!1-rvrur/uo•m cr'adurrrr [,111.1a-(Id 1Lwrrr.l,...errd by 40 an I0 hut' lucl: ol r ct .ehnnnr h,•md NAUI l_ o)toclir...... t rcducLr. r n r r rir r,d undt.mgt•d. d0, r,r .ur,•Ie oral (lu-c of I 1 h rniy6;;) a lo>s w.IS';L ol thc'micrm:rnm.d relntlrtnmc• P-.160 r,na. _ ,q1q lhr• rthfLuurirlhnc :W_drnuthvLr.r arlivitv wnys uhsd. wrlLin "-I hr: rrtvwe.ry nvu t•umplrlo cvrlihin K lu 11) days. Ilmub:u6ital slropirq; timra aml hl„oxl li•rrls wrrr rlrt:rtt•d nfbrl'iuduuni^ir.,liuwl_n nr:,/1:ny:fL::/n:ls~ 11rt.1 d.rc.).. Irt vitro 1 zhrr.vr m d mr iuhiLitomrlbrt eu.N n ..umal dru, rnrcrb: nufdid it nllFrl Ihu ry9,-,hr„rm• P-.li-u.cuutrnt .d'IIIL•.Itlirrn,ucllez. •Vhe rrrlenl' im~urp„r;niun nt 6;nninul+l I ~I •vulmic acid iutn ty'lut'hrome Ir 4i,t1 w:,.; m,t:,l,t,..l,~r[ hy i. 00009999 977
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I _NEW LITERATURE BOOKS PYRETHROiDS' Tha third mue of valume 7of Pminde Scienre Inrludes twelve. pper. from a srmposlum nn..the cnemmry, G«hemnrry endImstricmal auion or natural ana aYmM1eaaPYrctMada A[Itl m. part orYM1e IUPAC.ThiN Internatwn.l Cunjreu..on Pesticide . Chemnrry. MeBMkI, 1974. The.ropia eoeered lecludethe srruarunl and physkal'apecta af CyrHhrYln cbem.rrry, {ne mnder or'. p/qtode(GmpO]itiml. relatlbmhips Cetvaem.ehemmal smutwre, phPicalIproperties alb biolbaicat actieitr: detain aff new r,mthetl[c pYrethroid! Yralvding thom.iacking a qcmpropant rmaum' embling she mtuN pyreeMrms reriulq.cne mmae orscuon.of mrethraidt, imeractienr between the tial4picansti.r:Tof iwment forme of synthetic qrethroidr. and'r6e denbpmt t efroisbnp to pARNrads in.InsenR ' Or6er paperr,in the nme issue cover the detnduion M the herbi[ide meuibusin In ndd snd nmplb.stared ar-30'C, dnvibntion o1 Vhora.e and are 'deri.a••,.er, in Yirln faba ralae.ing mot eptakes orf thee mraauuEa. m e.bomm end hu. a/, the /b.cricide ttlaeophas in rau. meatur.menr al herbicido-.epr.y deporiu on fubage by. lluorescer.ce and pestiade resistance In Triarnsrsdn raqrariaua. - eapke of thh issue areavailable, price Ls.OG (USAand Canada:5r7.50)ipan4ee,frum9leck..e/l 9aennOc Publi[arions, OsnqMead. OafondOX10EL, England. The subrzrtatlun fx. Volume J(6 bsuml is {JOAO:(USA.and Canada 5/05.00). MOM= 0 =sMCM, EA , PUBLISNED BY G.:Y SOCIETY OF CHEMICAL INDUSTRY NONClNEARprmvammin 5f9i7'6 ! [editedby ktihard'.~'. Cottle and'.C. E. Lemke]', Providencn : American.Slathematical. Society. 1976•. vii. 200 p.. . iIL : 27 cm. (SIAM- AMS proceedings; v. 9) 'Based on lectures delivered at Ihe.: Symposium on' \onlinear. Proeramming~held' \larch 23-21. 1975:.as part oPf the American. SfatEematical Socfety's annual! New York' hlactinB""Proceedingr of a. Symposium in Applsd. Mathematics nfIhe.. American MathemaucaliSocinv. and4he SocictYz for lnduslrial and Applied' \lathematies. Includes biblineuphical refcrenc[s. (T57.8.\66 75-75a71 ISigN. 0-g318-1595'-4 : 3J12 . A. Nonlinrar Prqenrnrnine-Conrrrscrt l. Cottle; Riahard. ll. Lcnr.r• Ciriian E- 11T.. Sy-mpasium on 1'onGineuP1ner.vnnrine. Neu• Yod',. /975. LV. rtm{•rraan .ILrhrnwnul J(h•ri•0'.. V. Si•riesr Sorri-fr 1Lr. Indvsrrial and ;Ipplied. ALP6rnrerics.'SI:I;tl-A•ffSprnmdMgs, t S KILLIAN, Riy.A.658.3 Human rrsnum• mmerernr•nr : an ROI' approach f. Ray A- Aillian. \cw' S'ork :•a)1:1C0\1. e1976, viii, 232 p„ : ill. ; '7cm. Includcs biblio npli al refcrulces-j11F55J9:Kd78J. 76• 705g StilI\ (1.glJa-SJ1J I ..II 45 J:Pcrsonnrl mnna.enrt•n[ C Tide. VOL, 6! N0, 17, SEPTEMBER 17, 1976 AOAC PuG5lhea EPA Wariride fo.mulattane 6fennal The AOAC lise.uli(•dulyd' publication ofthe EPA. Alanuaf nf. Chemicnf arelAadr.. Jor Pnt;cidus end.Leeicea fon Jn1Y 1, 10776. . The manuwl, cmo-piledlhy rhhe Eirvnnnmrntal Pmt[cgion AReoef. (EPA) ud Stntc Iahomloarn. will indudearer. 3o0carr[ntle uwd mm6ag+fornaalvaine rommm- [Id pmliude (o.nndanan.-.ov[riaR'. errmirid.., fsmeindn, herbiuaMe,isa[clirirles.amg rml[nticidea -by m[an. a1 cas-limrid, Lhin.la>w, end hiph-pra- sure. lirtuid diromatoemph,v, fafrared, ultraviblet, and.atnmic abearptioao-spectromopy, and elisiul chnniral prortdur[s. Tlie 1n0o-pn[r;. lout••l.ef vnlum[. eponeared jointly by Ihe F-PA, the Amoriationaf Amerinn Pesticide Control Olhriala endd tlm AOAC, .ri6 iorlade eurh.sprrinl fentuma ns poniride..gonnu- lahan. bfuhupraldra, . uwr•r aee iadea, and mere.dban 350 inJividud infre.Rd spectrt of peali-. ride compounds. The manusl is ivtendrd for ux[ u e aupplrmeot to the.lRth. editinn (19Ta1 of the AOAC OpScinl Mefhnd. oJAnnfpaa. Siure the number of ofb:ial methods applicable to peslieida formulations ie limited, thevew$PA mnnnl maknn.ailrtb7r the ana151i[ul.procrdurre }rrrently.used by EPA..nd SlatrL.baratorin.in enfurrias8tete aud Federal environmental law.. The mnnnal is. eeaRsble fromm the AOA[7C at a' eael.of 535Af1 per eopry plue 5]:00 for postne[ nad huMlinP. Orders mny bea•nt ml AOaC, 11. SiO, Benjemiu Franklin Stet(on,. Washington, DC 20044. /NDUSTRIAL pnllutinn 614.7 tOnfral m{•a(nrOnttnP k ins(rumantariunproccedingsof aa sneeialtyy cunference.glten at New JcrseyInstiiute of TttM(dneq, Ncuark; New Jersey. March 22:23, 1276 { eJrtrd bv Paul N. ChcmmisinnfL Westport, Cun. : Tcuh'numiu Pub. Co., 0970. viii,. 317.p. : ;. 28 cm. "Sponsnrcd by: N6w Jersey Inslitute of . Technoingy, Dept. nfCicil.. & Envirann:cntal Enginc<rin$ ... (and oihcrs)" !nclndhc bibliographical references. fTDl7?.5.15~+J 7,9• 43003'I56\ 0-877/i2-136•1 : 35.00 J. Pnllutinn-.Yfrxwrrnrenr--Can,zrcssn. f, C6crcrrrisinnr7: Paul .\'.fL .Ycn• lortrv lnstimtt of Tnhnalu-,y. Depf.' of Ciil k& fiu'iinnnrrnrsl - Bngincering: A'07' of nrrr mind./ 309.1'73'092 (cpited b)J Dxle Tarnowieski, in enoperation wuh Carla (Ir.nlhard .. (rt aI.J.. \ew. Yurk..: AAIACO\L:c19.6: ::8 p.: i:1.:29.cm. Cimsists of ans(vcrstn a sllrvcy condurtcd hv Amenuaq ' Managcmcnl'. .lbxnciauuns. [IIN5@\6a3J 76- 2038 ISIIN'0-8I;15J18-S : 9:95 J. 1•i»lcd Staras-5ix'Ltl tvrnJir6rn(-Nd(A L' B4fn:C3,(/I)rn {rill{'Y•SlJI f ItUrU'[Y 7: ~n{•i:d prMlrrus J.1 lu+rn'and nr{ -(:m:rd'Strua:a.f: 7irnrnui:(.(i~ p:dr. 11 (1;1n6.vJ,. (jrlx /!f.' Anuni:m .Ifarclgrrnrmrt.tid~ranims 00010030 100E' 0
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ABSTRACT S ABSTRACTS 85:3d51-'y htodificrttion of cellulose hydratefibcr by erosslinkin);. ICtner-hl lk . h. 'L.: Ixshchinen A. U.: Grishina. Irf. S:; Unlubyntntkova„ NE.. (U1"iRl: Klrirn. VrrloHno 1976. (2),.fi7-9(Rass). An.inarease in crease resistance nnd a decrease in shrinkage of relfulo.cee hydrate (1) (11097-73-71 fibers is obtained by cruss;utkmg., with dimethxfolcfh.Lncurea (Il) [l36••83 r] •Ind h1pCl a.scrossllnkinK agent andeatalyst, resp. - frhidified I fd3ers, obtained at In ch. cnncnn,.. of rea,entein the Gn ish suhl., contained' S2U!k 11. The tcnsile.strent,th at breakaf I fibers. showed a max. depcndence on the If content. The crosslinked I fibers.had a low swellinF deeree in H,O. The pH had.nn effect.on tfletensile strength of I fibers.nndioptimum properlieswcre olitained' at pH value.e of the finishingsolns. 7.2-7.5. ' ' - 85: 40A011 New schemes of commutation oCchromatographiccolumns. Chizhkov. V: 1'.; Vushina. 0.. A,. llnst. UrF:.Chem.,. idusrow,. USSR6. Zh. d'naL.Khim: 197G, 31(1);.16-22 (Russ).. To decrease the time reqcired forr aa series of Kas chromatog.. analv.es by Cuttittg downn on. the flushingg time between samples„ 3 columnn commutation schemess witlva nonhented valve were.e cxamd.: a scheme for direct and reverse eulumn flushing; aschemea of subsequent and parallel column. flushinK:and; a.a eirculal'iun scheme. The reasons for appearance..uf fulse peskss during the circulation scheme.in chrnmauograms w•ere.fimnd andi. methodss fur.climihating these peakss were uF ested. 'Lhee application of the~e circulation scheme was illustrated byisotupey ana1. of CcHS.with.a flame ionization detector. The direct; andi reverse.flushings were used inn the anal..of a miat. of hydrocarbons. C. Weiner 85iA70t5q The synthesis..of aa cleavnble and hydrophillc euss-hnl.ing.renµ•nt. Sdtrainm..lians.I., 1 ueif r.'I'humas(Aln- Strul turt r.eh 1!itax-i'Iane.6 lnst.RieKhe m\i ntinsricd,. (,vr.). Nhpl,e-,Sr,lrrs %. Yb~ssnA: Chene. LI,G• •3,eG1), 47i-9'. (P:r.R). nht)Ctalll( li (:11_•VC'R ( li. SSCII I I{(1Y111'cClfzC'f:= NI19UMh lI lCl II'.1 uas.. prep'L.In Lrt amenCe f E 11 Cl{CN wlth~ I10CIiMai tiSClli(:II.UH in -l0'ti140H to give tlic nitrile which. was hvdinlvzed e:i/h IICI in 64e0lG i1-NC0CHR11:@)ICII_•1a0= CII:CFIiCOKH; /'!1) e:c:::lsns prcl+el. The crteas-linking nbillties.ofl!, 11 antFdimrtl-cl suh.nrra•. ~I;-. were cump.uul u~ulg Rl\AA pnly.nu rnse, rnd Oln„emate ,leltydr.(;ennse, wilh I.rivIng,lLe besCt results. 85: 3tI82Jp 'Phe.e vapor.phase mngneticc circular dichroism spectrum ofIhe. `A„ -:Arexcitation of FlFoxal: Linder, Robert E.; 8arth., Cuenter;.. 9urmenherg. Iddward;. Dierassi, Carl; Seamans„ Uocdi htoscowitz. Albert (Dcp. Chem.,. Stanford Univ., Stanfi,rd. Calif,l. Cbem. Phy.r.. Lelt. 1976, 39((91, .111-I6.. (Enk). The vapnr phase macnctic CI)D snectruma of the 52U nm hand system ot Flvoxa6 is reported. 'fhe vibrat.ibnal anal. of this spectrum, and itss temp:. dependence, extend and ronfirm,the assri:nnirnrs made hv.l), A. Rntnsavnndy his collaborators Irmn magnetic rotatinn.nndcmission data. 85:3680"_F Process forr rerlucinif nitrogen oxide emissionn frnm auto:nobilorxhnusts. fkukrr./:onr:;e..Ed~.t':ud; Jnland', Mark L. (hhmsauto.Cu:) IS[il. I'.-12a',tRl (Cl. 4:111ti). 15 Peli 1970.. .Sppl. 13 .1ll15/7Q, 23. \far 1'J7 ~1; 28pp. N oxide [1110-0-97.-1)) emisxiun frnm avlumubile exhuustt systemss was rcdurcd.d bv rwminvtlee cuniut•.. ult +tv:, mr a rirlt rnixt. anduddh,g snpplemeuml.air to pruvidv:w O.cunlrnl.uf <.1 2 eul. •i~hefure pl,.un: I bl. •;.Ifes ovcr a ca1 tll. t'collry 0.001 uall!/9 wt. 70 1(h (e1tIn.IG-Gl t•tuled un a prrrtlnm d SI:•0', suppnrt laYered nilln 1.. 15.71 w'l. P:Irls h+(SIIII 112 11) md, optinnnlly; Pp or I lr. 1 he . enL•dyst prnnwted N uadc redo. Uy. C(7o and I i in the.exhau.te uliil.tlimit.ing NH:, prndn. to etUO'ppm: Several delnilyd rsmnpli, were girt•n: . Vf)l . 6'., Nl1. 1]~,~ ~FP'RFMRFP' 17, 1976 1 85:4038.h Determination of suhmicrog•ramamountsof mercury imvariuus matmcesby flameless asomio-fluoresccnce spectrornetry. CavaJlt 1,. Rossil G. (Clu:m. Uiv., Eumtom-CCR, Varese, Italy). Analvst (Lnndun) 197G, 101(1201), 27.-7 (Eng). Solid samples (~•1011-2(10 mF)'were oxidized in a.Pt boat in a..stremn of 0, the combustion gases passed over hot Pt wires to aid oxidn. and condensed in a liq. N trap, the condensate was , warmed to room temp., dissol:edd in 10!7 HivO-i . andd the Hg extd. by the Sn1113) redn-aeratmn..proceduren and amalcamtned with Au. The.amalgam was heated2:5 min at 70U° in a.tubular oven.thentlle lig vapor flushed instantaneousl4inro.a windowless fluorescence cell by Ar and the intensityat 25:i.5 nm measured. The.calibratiomgraph was.linear atl0.5-100 ng and.the detection limit: was-0:0:3 ng. Relative std. deviation for 10 detns. of 20 ng Hg ass aq. xld. suln. was 4,5%. Ooodd agreement with NBS values j for detn. of H; .,in orchard.,leaves and!enallwas obtained. 85:34610u Vapor' phase process for cellulose fabrics. Shelton. Thnmas S': (AIcL"raw-F.disnn Co.) U.S. 3,951',595 (Cl. 8-) I6_4; DJOP.II'S/611. '10Apr 1976, App1.48i.7:31, 10dul 1974; 3 pp.. Vapor phase, crosslinking oE cotton and cotton blended fabrics in a closed chamher with H~CHU, steam•. and S0e.for crease.retention is under hetter.cuntitol by spet•i;ically.delaying discharging.g the catalctic SUr gas into the charnber untib40-0090 HCHO concn. in the chamiter has been reachedl Thus, itra 1000 cu. ft.. chamberholding, 1"oU 65:35 cuttunn birnd work shirts or pants;. 6 lb paraformaldehydee was introduced together with steam. After a 90 vec deisy. 20 cu. ft. SCr was discharged into the chamber (the .cteamm discharge was terminated for 5-15 sec. after the initial S0s discharge.and cunticucd'to llte.shut.off.of SOrb 85: 40:1^-Gx 'fhermal methuds in.analytical chemistry.. DUval,. C. (Lab,Rech: Micro,mnl, C?]H6'I'.uis, 1°r)... C'nmpr..inul.. Chcm. 1976, . 7, 1-20:i(Bm;)Ldittd!8y Svcitln. C. F.Isevier.., Amsterdam, Neth. Therntugravimetrie anal, and DTAa arr. reviewed.wilh 15 refs. . 86cN0323u Atomic.c absorption epectrnmetry, a revieww of modern inslrurncntati~on and techniques. Stone, R.. G; FVarren, J (Lab.. Cuv. Chem,, Dep. Trade ind., London;Engl.): Mist. Rep. - Lob. Com. Cliem. (G. 13:) 1973, .22, 29pP. (EnF). A. reviesv, with 63 refs. of at. absorption spectronletree app...lechnic~ues;.and.appliuatiuns inthranaln of inurg: and'orgd solids: aq. so ne., and.trnced elenteun'detns;. 8.5:.3G971p Introdue:tiore to nnalyses or osyFendcmandn organic carbon, nitrogen and suspended mattcr: mcans and goa.l's fur tLe research, lijonedali Itnkan.(Swed. 11'iter Air Pullut. Ites. ISab., 5tockkulm, Swrd.)- FAp Fish. Tccn..Pon. 1975, FIH1/'I'1'3i., '1:1-4(1 (F;ng). The rcvic•.r unvrre collsrtiun nf samples uf water and tvaste tvater, drtn. of ROU, COD, and total 0 demand and.of total org. C: suspended matter, and N cumpds. S,.13. Sent 81i:.4.3RaGr IliFhly, concentrnted oztracts of Dnlmatiun p)'rethrujo. Atjusurmnn;, pfa.umi Il/ainippun .li.chuFiku 6•n.,. Lhl.3 •/aWUe..linkui' 70'..IS,t"a (CI'I. XOINU/Otil. 26 Apr 1976,, AppL 7 A/1If1,liN2, 17 Oi:l I!1;.1; 2 pp:. Flu.crr..nf Onlmnrirue prn•rbqrm. wrrc. rxtd. witle luwer Itvdrurnrhons ondd thrn tli.r't(l.,, y;ielding the rrude rtl. I'vn911rin (lt was extd. frnrn Ilte rrurleext. with :t-10 p:ulsut 61vCN. clulled In•IowO° Ip ramm•e insnl. sub>tnucesmld rundtmu•J Imgivu.Ihe ronod. ecl. '1'hc ext. cmllain.d (o F.SF of 1• ,ex eompered scillt a0iJa':c of I in exls. oht:eincd by taiaih;, uu.Ih,~is. 'lhus• LtNI g crudc ext. of 1). prrrthnun (pltrity. ' -).d3':r) was slirare) :1 hr wilh. SIN) ml Mr("N nndkrp6ut.-e fbr IS hr. '1'hv.supernnlmtt'wasfillered andd cundnnsrd at rrdnu I pressure.to.o give 41.U7. g cunctl.. ext. ennlc:Jl!1,;{7;'n IS in.97.E19o rccover,v,. S. Cakvi

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