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Lorillard

Awareness Bulletin

Date: 19760319/P
Length: 63 pages
00009152-00009214
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Author
Anthony, A.
Bingaman, D.P.
Richmond, F.
Scott, S.
Skladanowski, L.
Characteristic
MINI, MINIMUM CODING
Site
G31
Date Loaded
13 Jul 1999
Litigation
Fali/Produced
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R1-001
Area
LIBRARY/AWARENESS BULLETINS
Type
NELE, NEWSLETTER
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ywf13c00

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Page 1: ywf13c00
A Division of Loew's Theatres, Inc. Research Ccntr•L'ibrary .. ' 420 English St..Greensbolo, N. C. 27420:. . Cable Atldress:tLorfllaraP . . .. . NEW TOqK'-OFFICi200 L.42wa ST. . NEWS BRIEFS CONTENTS IL.' SPECIAL,FEATURES FOR COMPANY U ON Y 11I. ABSTRACTS FRQM CURRENT LITERATURE IV. • ANNOUNCEMEIJTS. V. NEW LITERATURE ' PDBLISHER' i f' LORZLLARD " F 'EDITORIAL STAFF FlKSTID E% ' AODREE ANTHONY.,. EDITOR . FRANCESRICHNOND; COMPILER ~. D. P. BINGAMAM SARI. SCOTT. . LARRY SXLADANOWSRI COVER: TOBACCOPLANT.WITH FLOWERS DON.REDMOND'. . _._.... ....-._»~___. _ .,': _._...... `V°L, 6,. No. 6, MARCH 19, 1976 • • -- _-. . t---- :--- - .,
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" SPECIAL FEATURES T.ItL i--cn.p ari.ona if /A. rMslsanbsre O(wera Numbn• p®tier nu d'f ifmtn Wswn. . . . Imdlsted•Wnd 15 ~ b.. 0:34~0.16 . Irndi.bd,. . .~ 15 .. '} 0.ms0.o' . . IsndiLtad.bund' Ib ~ 0.6t0:2 -- , _IeaWiaud. u ~~ ,~~3 0.2*0.12 - ~~ In.duted-nrnd IS ~ '. 21 1df0.31 Inadi.ud 16 . 7 . 0.4730.18 ••.V.L- s.aLWr. WLL H-.i.. . . . .-. i / vl. c• bucd on the binomial dtstnbution w'as nnied'out A similar kighh leceloi'l statistical signsficmte (P=0-006) xas' again obtaine& Eor, the data at 32 weeloby this --- singlatail test (uble 2). '. 'C'he obsers•cd difference cannot b'einterpreted as an additis< tumorigenic e(fen ot'f two carcinogens because ' IwW tumorss were seen.a+a the vme period o['f time in ntsgi.en similarr treatmenti withcigarette tar alone (xe ' footnote b, table l}.Aats are alread••known to be rela- 'tirelr resistant.to the production oB'skin mmon by thet eucinos,•enie "tari• (and to.o the pol,rcys:lic hydrocarbon . . ... . nrcinUCeni) (6). and this.' further supports the condu. sion thatthe..cigarette sar.had a tumoapromoting effect ,. . . in the prescnt study.in combination with ioni:ingirradi- ation. . . . ' VoLa 6, A, 6, P1aacH 19; 1976 . .. p . F: .. (nurm.l . '~~ (bioomial dhtnbuucoi ~ dslnbur.wn,. .aioela'tail/' ain8l~nJ/ 0~:05~-~ ~ . 0.0! 0.001 . O.ON) . . . - .~..~ :~t.l...'REfERENCEB ' , . . . ., (I) Iy.oi' FE J., IAnnr JW. S.mr EN:. et al: Nanaity 01 ' uranlum minsn in relatioe to raliation vposure. baN! .. mckm(ninS.niL'tiFarene smuking-1959 rtlruuElr Srpum~. ~ ..-.bcr IS67. Hnlch Phr. 1a 5J.1-57a. 19rA (2) Gttaaae. A: The RarenoP,en,c.asuritr.oc dPrelse rabsrco. - tar.GnarRelai510.5U.19ia.. -- (3f \Ax Mmnru 01_ 5naa A, Sw.r. A: et d`. The mmor-promorin8 ar•..m ol.1 tuhamu kat and ro6awa: rmotr mn- denvtn J]al Gruer Inst N:5143%: 19G6 (Q 1'.a Dte¢n 8l 9..a AL A.n C. .t al: GrPerte .moka . aminegnesi.oimpnnanx.d tumar prammen J \.dGn~ . ' aerlnnl: -M:-71$.19Y1 ' (5) Wrc..nrn EL Horrsr.s Dx Toh.am and 'One.amSn. o-.. dupt 6. RevTnrk, Aaademla Prca 1961, pp 1]9-I/,-. • (e) Buranwat b Grdnoqenrn. and mnmrprrtlqvieiL fn A•G' . qnee in Cancer R«arcb /Lrttmmin Jr. NfdUew A, p1..1:. _ sel IL New yor1, AcaUemie..Pmr, 19i4:.pp 1"9-ITS.
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r Fos.:.s rox.1976'. 4/J THE JOUIINAL nF' PHAR.MACOLOGY ANI7 EXPERIMENTAL ri'HL'RAPLUTICS - Abstractsin.EngGsh VOL. 19'6; NO. S JANUIaf:Y 1976 ,.r EQeet. of Nieutine on Rebound Earitalion of Guinea•Pix Small Inttatine;. J. D:. ... .6lbod. R. A. Roan~and hf. ti..JerYson~ ..................... ......................... ' Schvvcizcrische !'"'edizinische BIRITrs 'IHIT , MEJ','~°'yi! CAL jGUi~,~AL ,. ' . Abstracts~~in,Eni4ish - VOL. S NU..6007 FEbRUr1fiY 2Si 1976 ' f~nn\Iwa uble. R.rwrb... me.w./Je 1 xwmnu 1 ~'xrn, n's~rx..u n.w~iu.., lmu ev.be.. C 8 No. 7956 WochenschrifY Multilingual Jbunnal-Each Abstractt in-EngOish and tltc Languaga of thc Articlc . VOL. f(i6 NO. '8' FEBRUARY 21 1976 Silicosis; rMroniS bronchitis and stnoking liabits; P lodrr„ IV.' 1Yiis1, A-ill QGldntmut -- ---~ ~~ ~ ~i LONDON SATURDAM1' 11 FERRUARt' 1976: Ph870 . . ~-. Abstractsin'Engitsh ~.-- ns IJ M.Iee..I W lr\ .. . O.'. NW'Gronb D.P.CV.q..aaaPrdA~IS'GnL.r.r4t..a.GEO.uN.r..4.MAlmebr '.
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MICROSOMAL N-OXIDIATION OF THE ~HEPATOCARCINOGEN N-METHYL-4-': AMINOAZOBENZENE AND THE REACTIVITY OF N-HYDROXY-N-METHYL-4-AMINOAZO- , BENZENEI . CANCER RESEARCH .. March 1976, Vol. 36,. p. 1196-1206 s'Fred Fe Kadlubar,, James A. Miller ~et al .<..., - :c, . ~`' The N-oxidation of the hepatocarcmogen N•methyl-l- -~! - Ominoazobenzerse (MABt.was catalyzed by hepatic mmrG- ~ 0 . ..••.... i. . ......_r .__ _ ._" ._ __' _ pendent reaetion..The initial N•oxidalion produch.N-hy- Oroxy-N-memyl-<-aminozzobenzene (N-HD-M'ABL was read- ' ', Ily, oxidized toa second produet.thar yielde0'.N-hydroxy-+ : , . aminoazobenzene upon subsequem acid treatment. The ~ ' teeandary'N-oxidalion product may be formed nonenzy- .. . . metioally and.is presumed to be N-HO+MAB.N.oxide or its - dehydrated derivative. N-/p•phenyiaiophenyl)mtrone. Un- - der: the same conditions. MAB was also oxidativelyNbe- atkylated. 10 1-ammoazobenzene.. which was. N.oxldlzed'to ' N-hydroxy-4-aminoazobenlene. Unlike the latter reactions, the microsomal N-oaidation ofMAB was independent ot Gylochrom9 P-A5g. as shown by its lack of: sensitivity to ' inhibitionby2•/(2,e41ichloro•6-onenyqphenoxyiemylamine. '-and its inability to uliRZe cumeoe hydroperaxide ireplacaof reduced'pyridine nucieotides and".oxygen. The N-oxklatron OfMABwasalso'eatalyeedlbythe~purifiedmicrosomalflavo- protein mixed-funchon amme exndaseof' Ziegler etal. The poncarcinogenic dye,N-elhyts-aminoazobenzenewas me- Lboli:ed. similarly to.MAB. For maleanimals the hepatic '' levels of MAB W.oxidase activity were in the order: ral > hamster, guineapig'> mouse, rabbit. Little or no MAB'N• oxrdase activHywaspresent in several e.trahepabc rat'tia- . . ~ asrea .. .. .. .,. .. - A TOTALLY AUTOMATED GC SYSTEM FOR COy CH4, AND TOTAL HYDROCARBON ANALYSIS - By Charles A. Burgett andLouis E. Green AMERICAN LABORATORY'. February 1976 . .. .. Vo1e 8, no. 2, p. 79 T il1 ANALYSIS OF TOTAL HYDROCAROONS lessmelh! aneand'.ca.bummonoxideAas . leen widespread interest by botb- Industrialand''l aovemmenlali agen- eies'.in Ihe pastdecade.Ctassically, ibe analysis ofcarbon monoxidee has been performed by nondis• - . , perriw:,infrared , andlBanreiuniza- .. . . llms ps <hromatogtaphylus been thee method uf choice fdr wsalhydmcarbons and nwthane. WOL. 6,' r10, 61 MARCH 191 1976 THE USE', OF A PROGRAMMP.BLE CALCULATOR'IN ATOMIC ABSORPTION'ANALYSIS AMERICAN LABORAmORY March 1976, Vol. 8, no. 3 p., 81 . M: F., Bancroft, P. Moran, et al T HF. DATA HAVDI ING prubfem m Oame atunn k absorption anal.u isqma si:nple, cumpared. so th t d b ' a presente y. many olhcr rypes of analytical inslrumentatiun. In most analyses, nnly'one. -element is: detcrmincdl at >2 tinm: and'd eadt tample. " 'absorbt a certain umounl of ntonne$rumaric IicbL The e logarithm ufthat absurptiwciscumpared to Ihal'.uf a known. standard,, and Ihe analytical result iithen presented.. o8nwiit digits, direnlv in cuncenlutiun... The- sli;lrtt amuwn uf inlcrnal .r•mpulatiun dtal is requiied cuuld b'rhandled quite adruuatdy even by .. _ prehistoric vacuumtubeinstrmlunts.. FLAVORS AND NONALCOHOLIC BEVERAGES GAS-LIQUID'CHROMATOGRAPHIC DETERMINAT'ION'OF CAPSAICIN Joseph J. DIC'eceo JOURNAL OF THE ASSOCIATION.OF _ OFFICIAL:ANALYTICAL CHEMISTS s Jan. 1976, Vol. 59',. no. 1 p, 1 .. .• A efmplkand er..m rhod he.: 6. devebped for tho-eunrii ti.dnerminaaun ol`. • eap.Jcin In r.IniFum rpieei and their aks rdnu,Up.eld es..rred .ith .r.r.nm. and aep.nred fmm inrrrferins .ul.uenre.• . ine',.w eai..red dumin. eeton,n. The eulYnn'tr f,r.s dm.d .ah.ennne• .nd rhenthes.n-iein I. eamed :ith areswm-nwrh.nal-..rer (73+23+ 2). T7re e.p•.idn f. su.nrimr.d h[xe••lwryld d.mm.rnanpl..,.u.ine a /:eMr.a 2n)bTednn solumn and' Pinerine . Im.rnd •tend.rd• 8e.ulra e.n be rxle,.lsrdle. Pe ernr eq,.ai.m se Seu.ille Ynit. .Hern.er, Of',uld.d renweie Mreard 1017e.
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ABSTRACTS ANNALS OF THE NEW YORK.' ACADEMY OF SCIENCES ' Thc.covccdurouf lhis journal docsnol corrcspund tothc xtualdatcwf publication. VOL. 258 S&TeNBFE: 30 1975 sS:CUNE)Co\FT6tElVCr ON Vfl•AMfN C• . Vitamin C andlCi&arcttc Smokers. Dy~Unrsrt.PeureTlea { Cardiovaucular Researcn .I . Abstnotsinl~slish . .... . _ VOL. 10 NO. 1 JA.'ntU1FtRY ,SV7fi ` Failuraof carbun mmtoxideto indhce . myoeardial I infarction.in chateslcrol-fcd cynomolgus.monkcys/;Nacara ' fasritularis): Al: B. ,Nnlfn.1w, P: - . AlrtaruAllu, D. S. Dirinelva,. J: Jlrrralfi, A. J:.Pduncr, /ff,.J. !lill, and IV:.P. MrNulry . .. . . . . . . . . . WoL, 6, iVor 6, PiARCH 19, 1 1976 O 8 0
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HIGH PRESSURE LIQUID..:. _:;CHROMATOGRAPHI'C SEPARATION - OF 10 BENZO(a) PYRENE PHENOLS'. AND:THE IDENTIFICATION OF ;,'C- 1-PHENOL AND 7-PHENOL AS NEW METABOLITES CANCER RESEARCH March 1976, Vol. '36 p, 922-92b ,..rn, rt James K. Selkirk et al l .• _.... i ~ . . . '•The separalion of t9n isomerirbenzo(a)pyrene phenols has been accomplished by thee use oLhigh-pressure liquid ehromatography milking'a newlydeveioped recycling tech. nrque ane.new.commn ana SOlvenr sysrems., . ' . Using this new system and comparing the metabolites Obtained'.with aulheniic stantlards. we haveisolaled 1-ny- droxybenzq(a)pyrene and 7•hyEroxybenzo(a)pyrene and Wentilied themas metabolites totmed"by'rat'.bver micro• - . somes..In.previouslyreportedcnromalographic systems. i ,. ' the: newmetabotiles migrated with anottrer metatioiRe. 3• ,I hydroxybanzo(a)pyrene. ' ' . ANALYTICAL BIOCHEMISTRY Janaury 1976 ~Vo]l. 70, no. ' 1, p. 287 ; . . . .. . . . . . ., , .. _ ..,q'; A Simple Economical Buffer System for Amino Acid Analysis' -' The elution positions of amino acids from the sulfbnaled resins of amino aeid analyzers is:afunction of'multiple factors'including eolummlcmpera- ture, flow'rate and bun'er compusition'.(1). Fully'automatedanalyaen principally umploy threre or four butfersfor discontinuous oestcpwisc tlution of Ilic amino acidss from the column, and buff'cr preparation consti• . tlltesa majormaintenance function involving time and effort. Commercial buffereoncentratcs are avail:rbfe at fixed.pH:and salt concenlrationtrom severNcompanies,and tfieir use for large numbers of analyses.represents . rsignificant' operating cost: 771ee bufferr system described in Table t is sihtple to prepare;is more flexibie for individual analytical.necds anctis inexpensive. VOL. 6, rVot 6. MARCH'19', 1976 DIMETHYL SULFOXIDE'-INDUCED ENHANCEMENT OF 7~12- - - DIMTHEYLBEtdZ[~~a] ) ANTHRACENE METHAROLISM AND DNA BINDING IN DIFFERENTIATING MOUSE EPIDERMAL CELL CULTURES CANCER RESEARCH Marc , oI. 36, p:. 947-951 Stuart H.'Yuspa, Henry Hennings et al .. :. ~ Mcuse eprderma/ cells In primaryculture mfferentiate rapidly over a 2-week period1 leadingrto keralimzalioroand sloughing of mosbof the piated. cells. Cell replication was . parlially synchronized in mese cultures with peaks of DNA' ,. thi syness at the 2nd andisih day. The ability of.epidErmal sallslb.metabolize7,f2-dimethylbenz(a]anthracenoand!Ihes subsequent binding. of activated.producls to epidermal DNA was a function of the.tulture I lme. Constilubve andd induced . levels oLaryl hydrocarbon hydroaylase rncells culturedfor Wdayswere hai6ol those incells grown for 3 days..Lrke-wise. 7,12-dimelhylbenz/a)anlliracene binding toeprdermalDNA was Iwo• to faurfolfl lower in 10-day.than3daycul-•tures. This decrease in metabolism and bindrng.between 3- dayand.lg-day cullures.couldbe eliminated by'the ihclu- sibn of 1.25% dimethyl sulfoxide in Ihe,culture medium during the entire culture.period.. , . . ANALYTICAL BIOCHEMISTRY . January 1976 Vol. 70, no. 1, p. 167' Rapid Analysis of Discrete Samples: The Use of . ~Nonsegmented, Continuous Ffow'' . •, KENT K. STEWART,r GANY R. REECHEA ir .. . ANDP. E. HAMEe - • Prorrin Nnrnrion !'aenrurorr. Nwriu,m rmrirmn• Arriru/rumt.RnrcrcA 5e!~ire.. Unitrd Srara Dcpannarnt rl AR•w'rraum, R.~Inr~i9n dfercnrnd 207p] und r crupF'rrlyd enhwor,.ry: rhe Camrxir 9nrrirxrlon of was6inrrru... . . .. . lym7ii.gree,D.C.SptU9 - Yxeivad Janu.ry ",.1975: accepted Auaust a, 1915 7fie pdnc'edes and.dcsign nf s hiea sped dimremumpkc analYxr arc pre-a:eted. The analTaer.was Opcnled al raies uptu i:a eampdes ttr Iwurwirh tetumtu bmelins betacn samples. N'hen typsidsrandaNS wxre.analYard,. toelhcicnu of variauan oflns rhm 1%werr amimd. - ~ ~ ~ .m ~
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A,BST. ./ t\/  S • Ja.nef a['Cbremorueroaap, 117.f1976)421J27~ - © EhevbrSeinsi4Publ&hina Company, Arrnterdam-Primed In The Netherlands VOL. 6. No. 6. MARCH ]i9, 1976 ,, 317 =s ~y F.: :.. . CHROM.7761 . Atyuefull-lengththermostatingwaterjacketforSwagcla.k.terminatedhigh• : • pressure liquid chromatography coiumns. „ _ ,. ,, t .. ..,'s,;,,,,,,;,,,,,,t.: vl..mn . . . .. . . . .. .. ~ 6uRrare a/~MObvkul CArmfrrrre~ Udma/rl al CAemiial ERimrr/4, 9201 ~~ Pn:p[m (HsuynPl. . (Recxi.tQ &ptembv ilyd, 1975) ~ . . ~ ~ . thermostatic control with am,oven or watcrjacket is.currently employed in commer• , eiallyy available LIPLCay'stemr. Apart from a very few carefully designed (although usuallyy complicated) waterqacket systemst, most systems gire inadequateJhermo> .. smticcontrol of the full lenglhof the.column, and their design is also rathercomples. A rclhtisdy simple jacket system has recently' been describcdb for jacketting long, wrrow-horc, coiled ian-ecchxvge.columns. ' use.of chemically bonded phaseialsoealls for eicvated.colummtemperaturesd and . . pressureliquidchromatographytHPLCJenlumnsiswellknown,a[lhoughinpractice it hfrequenUy'orerlookedl Somctimes. Ihe resolution between two compounds can .. e'hangee by as much as 12', for a..l' change incolumnmmperature'. The widespread ' Tha theoretical signiRcanaee of the adequate.thermostatic controfl or high- ls.rnalo/tYronnrerrapbY:1:17'(1976).269-278: ' Q Ehevier SNanrifiaPublishinpCcmpury, Amundam-Prinrcd in The Nnher/ands .. RIROM.576S• THEPREPARATION„PROPERTIES. A ND 3OM E.APPLICATIONS.OFT3OND- ED ]ON-EXCHANGE PACKINGS BASED ON MICROPARTICULATE SILICA- GEL FOR: HIGH-PERFORMANCE LIQUIDCHROMATOGRAPHK . . O: B. CO4, C: R. L'OSCOMBE, M.l. SLUCI/LC. K. SUGDEN and l. A~. UPFIELD~. L'aboraoayoIrbe Gbrernmrn' Carmfr/, Cem.nll.Hoau, S/an./orASVen, fowLw SEl 9.VQ (Grrw~ Drllnpl. ' , . . . ~ fRettbedSeptember2ath, 19731~. SUM.NARY • Tbe preparation of h'igNxRicicncy iomexchange collumnpackings based on silicagel:.ofi-pm particle siee.was investigated. Stmngration, strong anion and sreakk cation exchangers.having efreiencics of up to ]S'.0U0 plamsprr metre has'e been.syn-tlicsired. Thispaper describCs':Ihe preparation of U¢se materialq tNe elTccis o( tNC rari- ation of openting.paranseRrs on the separation of nueleosidcs'using qhe'.strong ration, exchange6 and the use of the:.ion-c.achangr.nsatcrials in a numbtr eflchromatographit' applications of interestt tothis'.laboratory: -~....~..-. .. ...... . _ . . . ,. - . . . .. . ... .. l, . ._ir' r•r , .. ~ .
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. ABSTPA.CTS METALS AND OTHER ELEMENTS ;.DETERMINAITON METHYL MERCURY IN FISH BY FLAMELESS'ATOMIC ABSORPTION SPECTROSCOPY AND COMPARISON WITH AN ACID HTOD FOR TOTAL ' G ' ME DIGESTION -.MERCURY q_ J. L. Kacpr.zak'& R. Chvojka ,.'.JOURNAL OF THE',ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS. ', 'Jam.'197'6. Vol. 59- nn_ 1 I1-+. P. 1S3 ,, V,,. ., Amerhod for Ilra eancurrenl detemdrulion ef Inclhyl me.eury and. iiwrFenie wneuey by . ' 4nleleu awnk ahwrption M•~TM~Iry (AAl7 . .: \n deev:bed" aiRp-w.en remple. nfjuwnile ' tr4d:aurlin fwh,wenenel.erd furinura•nie fald In.rhyt .n'rtuey, aml eolnl nureur,, wa. 1aakulrted fiy eddilim, ufdte 2 nilue., Trru•n- .. • di7vby of IM1e melhod rm <aimaed w he 0:0:9, . ag ter Innra.me mereuq e a V.vDa'. Ye e . aMlqh' rnercn.7. The dettt[hmlimill uf' Ihe - alHhad wuebnut 0.02as innraank mrmuq - ' ee omlhyl nu.eury, und dm eenf uhbe.lmd'nd ; waa found not lo e.rerdl IV„ fur .amplee di•paxthm nu rhr nh.orbanre gh(ng Jwm 10r4 . . uale. femplr. fronl Ihn w n D.h w. .' : alyaedey e emnnnnly nrol+rd gamdm. RAS % . melhodfnrthr'deanmhmtia ofrwulm ~. N'hemrhhe mull. r..r aud mrrroq from Ihr2 .ethudY Yem +wri„[irallr mn,pared, u.iny. e p.ircd Pte.r,thr diffrrs.,,e hrtw,xn the rr.uha ' ebwinM hy dle 2 nnrhud. wos fu.nd w be ' h.rigni6eanl ao d'le.935. ronfidineelesTL •~ DETERMINATION OF'HEAVY METALS IN SEAWATER AND! MARINE ORGAN'ISMS' BY'FLAMELESS'ATOMIC ABSORPTION SPECTROPHOTOMETRY ` .1. ATTEMPTS TO OBTAIN IMPROVED REPRODUCIBILITY BY A CONTROL OF'GAS MOVEMENTS'IN THE GRAPHITE TUBE ATOMIZER Dr. K. R. Sperling , • ATOMIC ABSORPTION NEWSLETTER . Jan. - Feb., 1976 .,..1_1. ' Vole 15, no. 1, pe 1 Theeensiriv7tp and reproducibility of'f meaeurtmenb using Bamelesa aromiec absorptiun epecrrophutometry' depends. slgnificanrly upun Ille matrix a1 the .. umple. Fureign auhstancea.cen uuse. an additional delhy in theunmiration ' proaa.7Lis in lurn can lead.ro an in•ercmrd variability in the de,uuction ol' the etamie cloud in the graphile tube,. :which markedly Ies.caa the o.erall.re• produaihiliry nf. tlle mee•uremrm+.. Wi1H IheItGA•7J, an atwmprwas made ' to wls'e Ihia pruhlem.by minimhingIhe' ' themisl shrgsiama.aol thce graphile . , telli.. Neverthrlrss, thee atnmic rlnud ' lemled In hr e-spelicd' frmn the mbe ' dming ile actu+l Inrmafiun.. tlm,: de- ' ' qea.ingthe xnailirilry. In,rhe presenl pap.c an IIGA• 1 Lraphil. Fun.are i. empldyed,.an emirelYn w prin,riple ie de..+ibrd in wblrh a sinclernd,d quuru window rell i. urd [n obwin a mnrc re~ • prmhmiblo formatinnund dirtru,tvm nf thee etumir rloudwilhin the mearoring ' beam .... . . . THE'INFLUENCEIOF RETINYL ACETATE ON THE POSTINITIlATION PHASE OF PRENEOPLASTIC LUNG NODULES IN RATS CANCER RESEARCH ' March 1976, Vol. 36, p. 996-1002 P. Nettesheim,. M. Virginia Cone et al The elfectsof retinyl acetate (RAl.on the development of Carcmogen-induced metaplashc:lungnodules were investi- gated. Four mg of 3-melhylcholantnrene were administered intnuxheally,tof3gd rats maintained on avitamin A-heeOiet and.receiuing31 A nmolas'Of RA perweeh,Dy inlragas-b¢ rnlubation. At 3. S, and'.10'.we0ks aller rntralracheali aMsldla0pn ot'3-methylchnlanthrene: one.groupof 2arats'4 tach was slarted on a weekly dose 01 31.41h) nmotes ol' RA: aControl group was Conhnued onthe low-RA oose. Filly+twowe0/e3o after 3•methylcholanthrene in(getion, Ihee inci0encee of' metaplashc lung nodules.was foundl lobe.3;h in theCombrned Aigh-RA-Opsegroupsl as compareo with l2e. In . _the Iow-RA-dbse'.group. It is therefore concluded thatRA' has a Lgnnhcanl efle0l',on the poflmroahon pnasa of pra- rNoplashc lung nodules rn rats. , :VOLr 6 . No. 6, MARCH 191, 1976
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ABSTRACTS : 84i.59552u Pyrimidinones and hydroay~ pyrimfdines. Lipinski, Christopher A:•Stam,.JohmG.; DeAngeiis, Cerald O.t Hess, Hans J• E: (PFiser Inc.); U.S. 3,92^-,345. (CI. 424-251F A61'K , . ,-AOIN), 25 Nov 1975,, _AppL.194,006„ 29, Oct1971;' 6 pp. Thirteenyyrimidinones I(Rt - Me, Rr = CI, Rz - H 2= 0) , and 8hydrozypyrimidines 11 (R4 =Cl, H,.F, MeO,.Me;RS = H, Me, CI) useful as bronchodilatore and (or) peptic ulcer inhibiton, ' wereprepdL, e.g,py ~ treating p-KOCRH4CI-H20 at.90-100° with -. CICHaCH(OEt)z, adding p.CICsH,OCHxCH(OEt)i to DitIF-POCb reegent, and cyclizing the lblesNCH:C(OCeH.CI-p)CHO with •NaOEt-urea to give.I (RL = Rs= H, Rz = Cl, Z=©). II. (RA _ Cl, Rs H) was similarly prepd. from CICHzCO=Et and p-NaOCeH.CIi treating_p-C1CsH.OCHiCOtEt with Na and . ~ MeOvCH,cyclizingNaOCH:C(OCsH,CI-p)CO2ElwithNaOble-= .thioureay and desulfurizing 5-(p-chlorophenoxy)-2-thiouracil ,, withBaney Ni. I gave 22-90% protection imguinea pigs against ,~histamine-2HC1 and II gave23-929u protection. li (Rt = H) - , inhibited.gastric secretion 31-69% imaats. 84h 55327b Pyrcthrrrtd' synergistic insecticides. Hirano, , Masachika; Ohno„ Isao : lakeda. Hisami. (Sumitomo Chemical : Co., LtdU Japan..Kokat 75 58r37 (CL A01N), 21 May 1975. :APpI. 73. 109,9b6, 28.Sep 1973;, 6 pp. The pyrethroid.compd.:I cxzozC-z-r-ex=a~r.. . ~ M • and organophosphorus insecticidess are synergistic Thus. I:0~3, . Sumithion [122-14-5] 27, and diatomaceous earth~97'partsare mixed. TRe rice insect Nephelettu: cincticeps. (resistant.strain against organophosphorus and carbamatee insecticides) was dusted with the above powder at.300 g/are:. AII insects were ` killed within 24 hq whereasindividual application of I and Sumithinnkilled90and~17%,resp. . 84t59548x N-cynlwalkyl and N-cyeloalkylalkyl.Isatoie anhydrides. Hardtmann, Goetz E: (Sandoz-Wander, Inc.) U.S, 3,919,210~ (CIl 260-244A; C07D). 11 Nov 1975. Apps. g28;757, 28 May 1969;. 10 pp. Continuation in:-part of U S: .3J187;559•. TAe.quinazolmones I(R Rr = H,CI. Me; Rt = Me; t a w m Et, PhCHz,.substituted benryl, cycloalkylmeth)-li Phi 4-FCcH.tn ~ 1-3) (r•45 compds.). possessing bronchodilating. hypotensive, antidepressant, central nervous avetem. stimulant,. and tranquilizing activities, were.prepd, by NaOH catalyzed cyclocondensntion, of the isatoic anhydrides II with IIf. Alternately. I IR' = Ch. R{ a H, Rs~. Me, n. a t) was prepd. by, chlorination-cycliratfon of 6-chloro-l-methvl-2-1(2-hydroxyethyUamino[-4-quinazolinone. :VoLt 6, Nor 6, IMARCH 19; 1976 a* N ~~ ~ 'r ~ x-•tc Ja ws x xxMCHZ1 840.587t9b Cyclopentane derivatives Caton Michael P I: ., , . ; Coffee; Edwardi C. J 1Catkins, Cordoe L. (May artdBaker , Ltd.)Ger. Offen. 2,502,919' (CL C07C, A6PK), 31 Jul 1975, :~ Britu Appl. 3730/74„ 26. Jan 197a;63pp. Cyclbpentanone - derivs•'I; R= H or Ac: X= CHtCH or CH•CHr YI = CO , , CH(OH), or CMe(OH); Rr = Pr, Ph, cydohexv4 CHiOPh, CHzCH7OEt, CHMA+ CH:Bu, CHIIcBu: CHBuCH;CHrPh,. or ,(CHi)iaPh] were prepd. tiyknown methods; dosages w'ere given lor thee use of I as bronchodilators hypntensives and'd hypocho:= lesteremics„and for inhibiting gastnc Juwcesecretion, stimulating eontractionsofthe uterus, andcontrollingthes menstrual cycle. In an example, 7-f(tetrahvdro-2A-pyran 2-yl)oxy]heptanal was ~repd: in 2 steps from h0(CH2)6CN and reacted with 1-marp- '- aiolmocy•clopentene, hydroivzed, and treated with. HOCSIeaCN to .~ -.yive 1. (R = H, XYR!' = CN),. whichh was convertedd to itsi cyclic ethylene acetall the CN group was converted into a.CHO. group .- by redn. end hydrelvsis. and the aldehyde.underwent the Wittig reaction with BuCH\icCOCH:PPhn to give, after hydFolysis. I lR = H, X=CH:CH, Y = CO,.Rt = CHMeBuY. 84::36489bClassiGcation and action mechanism of bro= nchodilators. Advenier,. C.; Bmcsier, J. R(Unite Biomed. •Cordeliers,. Leb, Pharmacol., Paris, Fr.)• J. PharmacolL Gin. - '-1974. 1(2),.92-110 (Fr). A review with 120.refs. ""'84:'38490g Physiological' and therapeutic aspects of br= ~onchadilators. Orehek, J.; Gayrardi P.; Grimaud, Ch:; •Charpin, J. (Clin. Pneumo-Phtisiol., Hop. Sainte-hlarguerite, Marseille,. Fr.)- J. Pharmacof• Clin. 1974, 1(2), 120-4 (Fr). A review with 10:rets• - 84:53876fEffect of cocaine on the responses of the ` differcntlyinnervated laryngeal and bronchial endsof the 6uinea pig trachea in vitro:to clinically uscdbronchodilutars. Jones,. ThomasA.; Hnmiitom Johm T.;. Lefcoe. Neville M. - (Pulm: Unit, Victoria Hosp., London, Ont.): Can. J. Ptiysiol. -PharmacoL. 19751 53(5), 810-15 (Eng). Log dose-response lines xo~/y Grcxrtaiom.r~ . ~ ... xa~ CH were obtained fordl-isoprenaline (I) [149-53-I]. 1-adrenaline (ADR) [51 41-J11.I-norodrenaline(NOR)j51-11-2].anlbtXamof . (SALB9 [18559-94-9],.and.orciprenaline I•586-[I6-1] unisolated uinea pigtracheal chains prePd from both the larngeal IL) and chial (B)) ends of the trachea. Responses, were obtained in the absence and presence of the nptaket blocker. cocainr [60-36-2] (0.67 and 6.7 aM)which markedlypotentiated responses to NOR and ADR but failedto significnntlyalter responses to I and SALB on L prepns. The degree of r tenttation ohtainedl on B Prepns:, was significantly less for OR,and ADR and was not significant forthe.otheragents. In addn., ezpta. were carried out on tracheal chains which aeveloped their normal tone in the: absencee of carbachoL and also on prepns• obtained from,5-hydroxydopamine treated animals. The 1 resent findings, based on selbctivepotentmtion of NOR and DR,, support evidence.lhat the degree of'adrenergic.'unnervation to the guinea pig:tractiea is greater at the laryngeal'end,and the results obtained with.h cocaine strengthen the.argument.that.it . has a pre-synaptic aitrof action. 000091 70
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SCREENING HIETHOD FOR THE DETECTION OF' AFLATOXIN, --, OCHRATOXIN, ZEARALENONE,`- _ PENICILLIC ACID, AND CITRININ . ' -• - °- " - D. Mr Wilson., W. He Tabor, and,Me Wr Trucksess - Journal of The.AOAC a - Jane 19'76', Vol. 59, no. 1 ~ 125 7 ' p . A' nwdl8easiun ( tbe nOirLl melhod for ,,. a .d,rnaxinr.and ..r.ernin; melbna t. afennne. aseto=in: and .ra,ratpxin;ade hea ,.._;~ . . ..,a ~. . end' e.pended to inrlude e16i4in and p 4 Ik acid. lfie method uree O.i<Y phoaph<rie ac J- ''°9 1!~- the extracl 1e d ided: aM elu1N fepm 2 01 mnm m om.,dee nuanlit;d.e thin la.er chro- _ r-- - ~ . mmpe.phi< QLG) melbod foe atluoxin and .. .' aehnto.dn i and dried' beem.. Afiamxin mld' ceerdenoneere rlmed fnmm onr rolumn , mld ochnmxin.. penki0ie aeid, and dvinin from Ihe rnher.Ochretoxin Areenw.ii•A sre'.Iuw (SO°° ) Inyeanma.2ear.4nune,l'enicillie.acid. and,Ntrinin wers que0lati•clY'rr:.ws'rrcd f.om soen'and beanss eennlenuoe.and funnirilliescld were rerurrred from Iw'.nule tiut rilrinin' oa not•8emnf TLCeolyenu wece used'to aew^te Inserfereneem. . A PUFF-AVERAGZNG'ANALYTICAL. CIGARETTE SMOKING DEVICE TOBACCO INTERNATIONAL' Feb. 20, 1976,, Vol. 178 no. 4, p. 49 . A. D.Horton, R. F. Apple, A. S.. Meyer & Me R. Guerin Amimpuyerl 6.pM IsuNayererint anarytknl el,rte0e 1mcFiry de+ice haYbvn /abricat,tl.and lesVd /m ml:Ndll11 by romparinp Ine data oWamed /lvn.il .'An tbose'oEminN tnrn slandard an alyCUl m_thrU« T'+e malenaf obconsin¢lion is prnuarilY Tellon ' tommin'ijelc[s(3e1 II/P•,'nY reacti%t fl:qFeGprlaldnenl). T/lif de- eice is nemned tno smuae sepu.mti.my v.c•qa.rus nlan, pun numAr nMIp inlSc't an abpvW el tM:ayer;Fd smoYninlo any r Isl 'bt analytical a.rvice or :nlo a ecld trap. Uiails nf eansnbc~ lion rna conwlrle circnil aia¢mms ase. slwre:. WoL, 6. No a 6, MkRCH 19, 1976 AUTOMATED GEL PERMEATION `" CHRONATOGRAPHIC CLEANUP '.. .;' ": OF ANIMAL APaD PLANT E3a'TRACTS' _ `''FOR PESTICIDE RESIDUE DETERMINATION L. D. Johnson, R. H. Waltz, '" J. P. Ussary, and F. E. Kaiser a::.l , ., . .. .. JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS Jan. ^1976,. Vol. 59„ no.. :1 ..... ;,:, Apldi.minnr uf an Impnnl•d ,eb+ullent F ~' 'tem for rleanup uf Ire.nkide ro.idnea by r 1 . e I.. ' In:mesnn duom.mprupb• (CP(--)) w<n' in- :.,G9C'- -. l.aiemed. 17btinn elur.rmri/nic. uarnp Ilro- .... .. .. . sr Hn.d. ?\-3 pel and e lulurnrvnlnl'. ac 1 t t.r :. ;. (1+3) rlnf.:.u «ol.rnl .en artrnnn:N for 16 ..rah • •, . .•.... -• .... . • noniunie ehlorinuud Drsiridn. 3 pnl.rLluc •~ ~ med LipbmYla (1'C.11e). 14 rhlnrolrlrrnpsY b- ,./ ., bieide earrs. and 7 urpmophuadmle Inreai- .-, ride...nul npallrrn.fnr.:rerblweand. ,al /Ipidr: sl. sod'ud.Ahunlilai.e.r n e. of thc prairidr. .Adrs+d. No liquid- fiqnid Imniliuninp..rleenup.arn• vev. "uirrd wilb u: p Irr of u,1 dd.u:mN p-tlriJ. ..::yb. nmlrir.tlntY fa'C rlr.nur wa. uv ' quirrd6n tbr nnninnio r1:bMnmN V^liridc., P(-u.,n:la pra.mqa,nrl'limr Iw.aridr.r.ia,:r. in eblrkrrr mut lurke. fnl tar..nrn ry:- t.rr nna' n:m :, t,h:.ln:n.rrir arlrn::.. . -rd In Ibr cu• rbr:rrr:aloRnp4ii mmb.d fro Iln ro y:nli:e pr-ti+id, . S::mlao untuinine :qn lo 0.5 n Iipid r::rlr n n• ,.r'd rt Ihr rate nf + 341-10 n •ilblin• nntnmmNlrY.- one l .n14.ui1• v.ilrnt',.Rrn:nrrnl'.wilb te Wn Y' f... .«oplyd..uuu:nal punilinnine nmlh- ndr nd..rre arbi...d ish sipnilirent .. ,. of InnI, Lslwr and' d,rmi.ala DIRECT GAS CHROt']ATOGRAPHIC DETERI4INATION OF' CATECHOL IN CIGARETTE SMOKE TOBACCO INTERNATIONAL Feb. 20, 1976, Vol. 178 noe 4, p.. 44 .. Me R. Guerin and.G. Olerich atcebnl ean br detmmined a, w trhnelnyl.Rr ei.ether in totnl exrtieulabmaller 1Tr"R1 bYdi:eel bsehmmolocraubie analysis.of pyridine eslraBs. Tne pmcedurc is'IYPicaLY'eeecurrd wiln e' mecl.inn o! J-4V. relatiye slandard dcsiauw+: Pw. nen- tucFY Ru(urnr< IIRILC'racttc war laund tuocl:vcr 0:19 mlll: f.''an•s a/.catrcnM percy,arette 40.44 wcd6nt'pereenbM o/ TFSSI. Tne rnuca:,¢rean:r eateehns autiw:.Y' bY. Ovetunq IWVCCoo tnen butlry tonarco was con&mna. Thr nrrwaWUrenromiseslo allow tnc aimunancous dctornanalion pl'nicnlinoalW plycerul:
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AY1/LJ' S B 6AE TW' ABSTRACTS Jmnvl.f'Chmmmmarµ.6Y, 117 f1916173-J6 ' "- " ~ q.flxrinScienhfrc Puqithina CmnPanY, Amuerdam-Prinkd in The Nahedands CNROM:1637. DUAL. ELL3CTROCHEhfICAL DETECTOR FOR. LIQUIDCHROhtATO- ORAPHY. ..,~ CLEROYBLANK DrPwMUwre~ChrnJrrrl. rlNkrrlrl <fOlfu.Wnb,. Npmnn.OLk- 7.1069:f US:.1.1 1FUsercreivedlune:14th„ 1973;.r<r'u<d' InanusrriM reaeised Au[ust IStly.1975)' ..-. :9'.- . ... "., d-ffi SUMMARY ..h+ . oCcertain.speoits Aforeover, only those compounds which, displayclectroaclisity - (oxidation nr reduulirmj al Ihe ellofeRfblemial(sJmre delcclCdl ' - Twodistinclii'emodesofoperutionareavallable:with,thedualdet<uor. For' compounds nhich overlaR.chrommographically, but have dilierin_ eleclruchumical formal potentials. Ihc'.syslem olkrs an instrumental scparalion. Far routine in- ` 9estiEalions, thc syslemprovidessigniGcant lime redoctions widwut causinF prnpnr- ' tionale Illerease5 ill COSI. - • " Scltclivi/y; sensitivily;.andwideidynamic mnge are all'-0ispla.'cd bylhe dual efectrochenlical detector for usewithfiquid'.chromalocraphy, Exhibiting.a linear ranpt of.about.l0', itt is; nt the samt time, capable of sensing sub-picomole.quantiii<s Aarm7rlChr.vnmufraqbn 111 (1976) :'9-31' rCEluvRrScicmlBCPUbliihiitaCOrnp+ny.Anstcrdam-Prin¢d.inTheNe+Bar6nds„ ,. , . ,... .,.. .. .. .. . CHROM-a631' ,• . . .. . . ~ . . . . , . . CONCENTRATION TECHNIQUE FORDETER64INAT~ION OF AIR POL- LUTANTS AT SUB-MICRO LEVEL . .. . . : A NEW TECHNIQUE FOR CONCENTRATION 017 CAROON~M'ONOXfDE ANIL KUMARA/IOSI[.OWARIKA PRASAD.RAIWAR, PANKAJ KRISHNA. BANDYOPADIIYAYavd SALIL t:.LMAR,G11OS11 Cmnvrlf'mrurlS.rurch SmrA.n. &.r.n AuuJ: Df/oMuJ, DtAwll.ufiul'(FIM nsei•xd hhy =1rd, 1975; reviaJimanuscrint received. Annna IR+h, 1975). The adeantnges, scope'and limitations of a slcp.wise techniqne.for eoncen- tralinp'.permanent pa+<s..panicululy'carbon, nronn.ide; up Is.2pA) linws heferc yas d+ronratographie, sCectropholorntrric.or tnuss spuctromeviedeterminminn:rrcde- reribedc fRtrrmin:uiun ul:Iess.thau 0.01 ppm.of carbon monoaidehas bcen carried' oul. wilhan error of 1.10'. by u.inFthisprc-concunralion teelmique..fullonod by ps.chrunwtnFmphy;:wilb calal3tic cwnvcrsion ul' Ihe cub'sn monoside inlo methane before Oam<iomatinn detectiim- Ihe system u.ed without Irre<onccnfratinn could Rol dcletl ksnuhaw Ilppinuof enbon monoaide.. SWIhrARY .VOLr 6, lVOr_ 6, MARCH 19, 1976 e 4 S
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ABSTRACTS ABSTRACTS, - .~. PRESERVATI'VESI AND~ 4RTIFICIAL SWEETNERS DETERMINATION'OF SACCHARIN, SODIUM',BENZ'OATE, AND •CAFFEZNE IN BEVERAGES BY REVERSE PHASE HIGH-PRESSURE LIQUID CHROMATOGRAPHY . )~ 51`' . :34 Dan,S. Smyly, Betsy B.'Wood- ward, and.Edzvard C. Conrad . JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICALCHEMISTS' Jan. 1976, Vol. 59, no. 1,,- _ pe 14 A w.eru• Idu*e hirl.q.nuure Iiquid. rhrn• , nalnPaqhic nvlhod h.Pr.aentrd fiu the NmuF-...... :YnroYr ar)ur.tmne vra ue1'qminamm nf e.o . eh.rin, eWium lu•noa, and eanilne in m0 -d'rink... (ruHjusr , fruit. eurkta:6,4 fruit punrirr.• ruRrr,, and arli0ei.1 ..nvmer eanrrn• - tnn•.• Ue'.rhonno-d -dt drink., frui/ PunrhrM1 . and. arrl/ield a..wrnn r nrrmran. an in- ./Lbd d:.erls inn. d.e el mrnaruuruph. F'ruiljhi- and mffrc ...Iminns rryub.• frOmtiun . Ihnmuh . 0.15 1. m Ixur nx•mhr.ne frltrr, yrinr In Ini-li..n• F.nrVlr.. • •luud'& frum e,.. unudm•ac/('.n rdun.n winr S).IerieL arr0. ridandam 9unmirarvi wiW nr ulfrr.inht dFo-rw:,1hr rc.uh.uf'.a,.ilarin,.ndiunm In..- awre. and eaR.in- deo-mdnalinm in 31 vdr -drink. (npmendna 11 ,n nnr,elnn•r..d 20. n»w..)s.efruh)oi ,rRuO.,andnund,r..r. 7 mlrr.rc.o and s.niit ull r...etr,er .n Irmr. areyrn•.em,.l- b.v.ue.nore.ir.af'ur, rharin• ndium Inmmaq and naRrine lmm~ mft. drinA6 an• 99•0,.99.3• and i 100.2%, mqnv•' IGely. PLANTS DETERMINATION OF. TOTAL NITROGEN IN PLANT TISSUE, ,USING A BLOCK DIGESTOR ; : Robert A. Isaac and Wm, ;• C. Johnson JOURNAL OF THE ASSOCIATION OF OFFICIAL CHEMISTS . Jan. 1976,, Vol., 5.9, no. 1. p. 98 ..1,, - The devnmii,afnnvf totaf nitroat•n Inqdem. .. :SII- c... • . - Ilr4ne. n.inc a Tvehniien IlUitll diFe•ror nru• I elded une, nf rhe Lee,.analuiul rw11 fnrQqrl- ..... - dahlldim.linn, The mahnd ii rq0d.nd Ipreci.e. ..r.. ..- .-. and uti0ro- thrn inlnmm Idwr.mq pnm. for' ... . audr ulx•rmi.~nu.The aumxmi. found iadetrr• .... mirred u.h,lt Ihnamumatd rominunu.. Oa. .. nerOwdd,¢z o1', a,. Am.A,ulyrar. Cn la 300. ... . , .am01e•/d:y nn> In• erul,rredl.iJ.....indr •..• .. lem. llrrmrry uf add.d nirwunr ue. 10UB=_ a.17.'• (Snnnad..m nilh tOMT n,rlhnd'..2:019, ae, ued:Arrnore nf O.OZC:, niln.urn rOr e r~+~ ~ ,tira.vue.•. . . ' MYTOXINS RESOLUTION OF AFLATOXINS: B1, B2, G1 and G2 BY HIGH PRESSURE LIQUID CHROMATOGRAPHY W. A. Pons, Jr. Journal of the AOAC Jan. 1976, Vol. 59 nae 1 p. 101. Anafoane rere comrind> -d.rd a. atum prake in. he nrder 0,-1/;.G,-Gr hY Il:eh-L.e.• .ure liquid d,rourmneruP/lY nm,..nurtl~N•rtiide (10 yn.) Pur,.u. .iGre ed'.avlu in 7-13 . ' (Or throuuh G_) by . .nu•r-.aturmrv/ rhlbrn- /am,<>dulv.anr+relonllMile elwinn nrhenl (25}7•3}1.0)• idr. deteaionhY uhru.idel e8.urlwnee au 360 u x Th. r.•larien.ldp.lx•. t.een Peak tieluhl and'.d unr :niroted..n lin r •er a 3-10U nR ran{e for eedr nllmu.in. Delhr<.oml..n,rimeh end Pr•k hein/.l. a hirLly. rryndru•ild., muh:ple inlnn,•nrnf mie.dlatandaNL ySine nn•Il:.irnl. eli.arietinn Lfr: M•:r ef 1.0-1-V o(rerrntb.n li.ne) and (Vrak hei.bt) 1or. Ure J'..D.m.7n.. f/.rrrrhm whh. nuwn IMakhriahl• sn/r.a.,of Ll (IIrS~ Li (0:),J.: (G,)• andJ•1 (f:.),..Ilnrin.detm:u.r uf.1-2 n[..uf.arh anatnaa:. .
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. , f ABSTRACTS ,,- INFORi•fATIDN THEORY APPLIED TO SELECTION'.OF PEAKS. FOR.RETRIEVAL ..OF MASS SPECTRA ' ANALYTICAL,CHEMISTRY March 1976, Vol. 48,. no:., 3, p. 595' Geert van Marlen & Auke Dijkstra. Orus7np,Shannon'sformufa, amounlsol Inforrnatbn have , '- been ealcufaled /orldenti/icalion of binary coded lowreso- , ' Wlienmssspeclrsbyrebieva6 Whem:a~thresholdof19o.of . Fo basepeak.IS used for.lhe decision abeul Ihe pmsence -- ., ; arabsenee of a peak, these binaryy codedlmass.spectra ... , yfeldanamounlol4nfbrmalionofbpproximalcly-00:bils.lllle found that. /nea ibrary of ea: 10'000 nrss speetra,, a fcl of -~:a 120 prescleclod mass vafues In the ranye 1-a00 eonla&1s _. tke tolai' hdormatien: mpy.Ihe nonselected nwsses do nol .. aupplyanyaddlllonallnformation, _ . ~.. ._ _.. VoLa 6, No. 6, MARCH 19,. 1976 . ANALYTIC7YL BIOCHENISTRY January 1976 +i Vol. 70, no, 1, p, 290 Improved''Techniquesfor Scoring'.TLC Plates ., . ... . . ...:.. ~. .,..1; . The scoring or thin layer plales prior Itsdevefopmenf prevents19teral spreading of chromatographing compounds;.oblique /low, of'solventsf and :, faeililates the use ofd'ual beam.densiiomelel:'s. However, an "edge effect" ' hasplaguedchromalograpFers:whohavelriedscoringthinlayerplatesinto ?separale lancs(1-3).'fhe edge effect. as used here refers to the abnormal ~: solventBowadjacentlothescorelines..ltesolutionofthesamplemixlureis ~ frequently unsalisfaclorydue to dislortion uf the bands'. Chipped edges on ° seored lihess also have been eiledl as the cause'of errulic results' in quantitative measurements.. Hirsch (.1) suggested that chipping could he ' minimitcd b,vrepeated scoring with light pressure:.ln the eourse of studies on identiffing and quantifying amino acids ikbeans, we.hase.pbserved the edge effect and the chipped edges omscore'lines. This paper desc.'bes leehniqpes devised to ovesome these problems. _ ' . AN ALL-PURPOSE INJECTION " .SYSTEM FOR GAS CIiROMtITOGRAPIiIC' ANALYSES OF'BIOLOGICAL SAMPLES •. JOURNAL OF CIIROI•]ATOGRAPHY .,,,`r-enruary 197'6, hol.1?, no. 2 p. 67 r J. Karlsen,& Knut,Einar Rasmussen " ' _.t .•., A sarsatOn Injection syvtem /or•lhn dheel INreduetloo-el samplns Intuthe.0as oluomalopmph fGGI Is doscribod. Sewoi'yoera ol o.porionce In bialOplcsl and.Chnrm.coulical ehomistry hare lod to the:cnnslrvcll<n and Irnel modiflcalion of this dorlcs: Np modlllcallon of Ineln/ocdon poRol Itre GC BINDING OF' [3H] BL'`NZO(a) PYRENE TO DNA IN'CULTURES HUMAN BRONCHUSl CANCER RESEARCH March.1976, Vol. 36,, p. 1011-10.18' Curtis C. Harris, Arthur L. Frank' et al The studies reported here demonstrate some of thelac tots allecling the bindingpf benzo(a)py.eno-(BPI Immacro- moloeules In cultured:human bronchial mucosa. Bronchial specimens'were oblained at either slrrgery.or"Immedmle" aulopsylrom patients with and without lung cancer. Grossly nprmal-appearing pieceSs of bronchus were oullured in a ehemicallydefined medium. i.e.. CMOI 10L6.medium con- talning 1 yg insulin per ml, 0.1 pg protinyl ae0ialo-per rnl. 0.1 pg hydrocorlisone hemisucunateper m1; 2 mul-glula- mine. 100:units.PCnrellin 6Per nd..and 100 rrg slrePromycm por ml. Aflcr 7'days: ex0lantcullures were exposedd to (rH16P, usuallyfot 24 hr-and Ihen bmding tolotal cellular macromoleculOS'S was studled by auloraalography. and binding to DNA was.measura`d lollowmg Isolalrom.ol DhA lrom brpnchiaFl mucosal cells. The extent of bindrnqg ol [aIQDP was dependent on nose of BP. Irnglh of <xpCsurc 10 ['H/BP, and tcmlwrature. Oy aueorddlography, bronchial epollClial ce lls bound more.l'l/jOPlham.slromal bbroblasts. Both 7.0-bendollavone and butylmed Iiydmxyloluen0 4o- ppated to:reduce Ihe ICre/ of RHIpP bound to DNA. white nicotlne.apparently did notdltetlhe level o/ binding. These studles demonslrale.lhal the broncnmllmucosa. an rmpor- tanlbuman cancer Ltrgll trSSUC, h3s Ihe cnpablhty to form ~ metabelrlesofDPwhqhbmdlo.maeromolecules+ncludmg DNA. In adddmn; 7,8-benral/avonc and bulylaled hydroxy- tolueOo6 both known to alter 11,0 mrcrosomal' metabolism Uf • BPi reduce Ihp:levul of ('HIBP bound to DNA.
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ABSTRACTS TECHNICAL COMMUNICATIONS SUBSTITUTION OF CUPRIE SULFATE'FOR `MERCURIC OXIDE AS CATALYST FOR THE KJEL,FOSS INSTRUMENT ' " L. Ie. 'Wall, Sr: and C. W. Gehrke _ .. t-i=:7 i~ zt. , . . JOURNAL OF THE ASSOCIATION OF - -OFFICIAL ANALYTICAL CHEMISTS Jan. 1976, Vol. 59, no., 1•' pe 219 '. - nd Owfnm -~~ A mAl.ra af eulr4 eulfnt ' dinxideend'auprie.wlfere.June.er<natumed . . oponibin eatdr+tot,r replLce memuric ezide Ii.rhe derennF,mtun of µrvuinnirmeen, uunrt tM Bjel-Fou eummaudIn.vument.d It n.e .eee.e.rr, tomodifr the.innrument in Incre.se the dieeaion rimem frdm 6 to .hnm OSm n to z'hieea amrptebie. Inoteini nirmurn . reco.er, rh eutnic eulf.re a. the cetdrst. An esperl- mental' r.n,Ai'e .et ob. oltroµen-emurinine r+I/a .' and Amerleen.Aewuerinn af Feed fnntrol Offi- ' elale chrck feed .emVh. ere sn.lYred uill. the Kjrl'-Fn.. in.nm„rnr to k. .yndurd n- Giturariun nid'r memrio ncida-e and us modifrrd nbb eunrir >ulfae .. th4. entet..e T.e s..u¢e - prr eem nnm,rn...undurd'dea+tiun;.nnd rde- ' Iiir xaudani de.iallun dth m.nvrir u.id-.nd . fupriz•ulfam.ere 10.37'end 10.36,0.0J0..ud 11.012. nnd' 0:.i3 and 0.36. mlaTti.dK The euhaimriun uf eutn. ,adfarr fur urie . axWe le fr..ihl.•, and irliminarrt therrc ua- nf the twtemidluallnt.uu, nwm,r.. , ATOMIC ABSORPTIONI.NEWSLETTER' ; Jan.. -- Fefi.., 1976 - Vol. 15, no. 1, p: 7 PRESSURE MOUNTS FOR TOXIC SUBSTANCES BILL C & E,NEWS . March 15, 1976 Vol. 54, no. 11 p. 23 ~ ... ., EPA„OSH'A, other federal agencies concerned withregulation of toxic ehemlcalsare'.touting need 4orr control legislation With passage ef taxk suhstanres cuntrol'. 1lFiklalinn furnsecahle thi:.vearfm ttie. 6rsl time since its inimductiun in 10 "1. it. - appears that federal agencies eoncerned' vitkregrdatih,q:noxicchemiiaL arevnek. ing a rnncertedellurtllo Rive thn Ic;;isla-tiun an added push. In remnt x eeta, np-peals hxve hcen mede hv lhe sdmlo{a-tmtur of the Enrimnmenml I'r,nertinnA,enc3, Ruur11E.1'iain. betnre.thz tia- llunal Press Club, bypssialont sceretary, of Labnr.and Onupatiimal Szft•tv &Heallh Administratinn hond Slurlnn Curn at a hianuf:mtarinR Chemista Ass<riatiun lun<hmn, and hy , the lChiteHm,uCrwncil on Enuirnmm~nal Qualitq in hr dxnh annual report to Prenidnn Pord and tu Cnngrnss on the state uf.the GS, rnvi- n,nmentilnuludlng air, wateq and turic p.llutonts, among others). ANIATOMIC ABSORPTION (iI6LIOGRAPHYFOR'J4ALY-OECEfrSBER.1975 ,.. $abinn,$Inuin.and DinneAl. Lalurence The PrrkiirEliner Corpnrntiom Nnru•a1k, Connecticut 00.56 The biblioFrnphv liaed below haa been eempiletl fortlmaonveniencwof our readkrs. Copier o/'the arfidra-ore rm[ amA' abtefrom Prrkin-Efines.' Perkindilmernlli supply eopin.of arlirles ahleh n'ere putiliahed in the Atumic Rbr.orptum Neuateter: ondanme aclectrd uli8b Irom other aourceaa'o determine,which reprinls are evailable,please write lotlte AdverlisinBDcpartment, request- . inRbrocliure A'A•J'JY; Ta:hnique:and Applicatiooe.ofAtomie Absorption. :VOLr 6. 140., 6, MARCH 19, 1976 r x
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REPRINTSIIN,LIBRARY FERGUSON, LLOYD N'.""". ;r Journal of Chemical Educhtion 1975, 52,, 688-694' 68&p. ALMQVIST, SVEN-OLOF AASEN, ARNE J. KIMLAND, BJARNE, ENZELL,. CURT R. Acta Chemica Scnadivavica 25 1971 pp;, 3L86 ff ,.':i'~S Wierzba, M. Kozinska, Z. Biuletyn Centralnego Laboratorium Pr.zemyslu Tytoniowego 1974, 3/4, 45-5I6 69 0 2 Wittkopp, R. W. Minerals SCience and Engr. 3 1971 pp.26-32 6901 Wiley, R. H. Chemical Reviews:" 1945, 37, 401-442 CANCER. HOW CAN CHEMIST HELP? +1-methyl Long Range The Meth _ I ..,.. 4 Spin Cotrpling in Aromatic Com- pounds THE EFFECT OF FILLING TOBACCO WITH DIETHYLENE GLYCOL ON THE SENSORY QUALITY AND CERTAIN PHYSICAL PROPERTIES Energy dispersive X-ray analysis. I THE CHEMISTRY OF THE. OXAZOLES .
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BRIEF'COMMUNICATZON': TUMOR-PROMOTING ACTIVITY OF' CIGARETTE TAR' IN RAT - SKIN EXPOSED TO IRRADIATION JOURNAL OF THE NATIONAL `' CANCER INSTITUTE Feb. 1976, 'Vol. 56, no. p. 429-430 - j11M6M8[-A Oussfeld Inereaa. (M_ .006) In the numterof ddntumnrs IndisW a7 besa iradlalion was damanstratediIn ots after suAaea applkationa tf o[aretta tar. The a0sat ap. jurad dJe to ammor-prumM.:n` aenetry,of the rigaratla rar ramer tnm to an Wditiw nrmorfaanie NNet af thatwa nansss.-J NaU Cancarlnat.S6:.429-430..1976: IMing.a study to.determine.whether ioniring.irradia- tinn may synergjke with certain enrironmr:ntal avrcino- Sersa(I), an experintenrwas undermken to seeiT cigarette tar'had a 4umor-promotinge8cetinthe skin of'.rats al- .. readyy erzposed u, irndiatiom Tumor-promoting actirity of cigarette tar clearly hasIleen, dessmnstmted fn mite -- after'treatmeni of the skiYs wirh, othertumor-initiating _ageno such as beum(a]p)renr. (_). and 7.IYdimethyl- bena(ajanthracene (),a):. the nuudaer of animals with . akin tumors warsignificanfly greuterafter the combinr.d treatments.than alter'trearment withdtcse.nrcinogens in the absence of tlic tar. Theevidence presentl:d t¢re indic-tes.that cigarette tar. )nomotes in a hke fashion the development of irradiatiursdnduced tumors Thirty malcrats oftite Charics River CD'saaim(outD hred albino) were uwd. 3t'.the t.im¢uCirradiation, the animals were 63.da}s old, whids.correspond.4o the begin.- ning (anagen) of'the third.hairgrowrla cycle:A 8arsource of stronciumAf1 titanate (140 mCi) pro- - tided a dose rate oFf about i01/rads of Iseta vdiation(minute acthe surfaceof the skin+Skin tumors were ih- dtsced wids.a single dose of l'.,6UU'radvadministered to an area,.5%.3'.em, on the dorsum of.an anssthetizak shaved animal. . . . Cigarette ta, wms prepared from US. blended ciga- Rttes (Orchard Park'Latioratories, N:Y:)- receired from sheA supplier ons drrira ami ntined'i with acetone on a 10 : wy:ul b+sik ~[mh supplv o( nr w:n obmincd oncc a month. Apprucimatels 0:13 V tar was painmd arer dte irradiated area dsree tisnesa wcrk. Fiflenmof.thr3U rats were painted with the cigaretse tar, beginning 8.wnks a[ter tne umutanon. RESULTS ANO mISCUS5ION ' _ The gross appearance of most of the irradiation-induccd tumors resembled', .. that: of wartlike or kenta acantlioma-likc.growths (6g. I). A tumor was.rcconkd when't it Isad reached at Icast 1 mm indiamcter and Isad . persisted for. 15'5 days. Tumors of thee irndiateJaarrerf group ssare,.on'the avrnge-,larger than those of'.the ir, radiated qroup,. andd a few' of themm hadd regressed to ~ ulceration. The sutietinl significance of the difference was as- :essed in two ways (5). The.first usok.iutoaccount the , number oLtumor-bearing astinuls. A single-tail tcst baud . on a contingency table and the Fisher exact proUibility' test showed' that thee difference in nuntiscrs of minulsin the two groups was on.the liordcrline oC,sussiniul:f significance at the two earlier periods, of obscrvation (taAle.1). For dte data at 52 weeks, an alternatise analp.is:.. ..-eomparingonlranimals w'ith, multiple tumors, yiclu:d a, umilar level of statistical significance (P-0.01); . . The second approach considered the numsserh of m,mors!animal. The ratio of the difference of.the ntcanrdividM hythe sc of thediderencee indicated a.sicnifi.anta yield (P-0.(Nfl) in thr nurnbcr of tumurs in ncc'; Gtoupaat 32 sveeks:.withprohablesignifinnre at Ihetw'o, c:rdler' - periods (table ?): Tbe ralidi is of' this anals'siswas.deter mined with evidence of iudcpcrtdcnreprosided'. by a~ dosc..fit (P'=0.135) to a Poieson diitribution-whichtvn-.- finns the assumption that the tumors alreadvfdrmed did. ' nut markedly influence thee formationn of new tnnmrs:, However- since the obser.'ed data.involse emall nundrcre' of tumorr.(N<28). and the use of large sample approxi- ' mations may be yuenioned. an exactL probability test'. r aereirN June 9..1975; xapud SeptemEer 16. 1975. a6inlnrr and Ilealth ph»lo DhiJUn. AtomlcEncra) o(LanmlrIlm.mO Chalk Rirvr. Onouo. Cauala. at am rrvrdul ra.Dr: R. >[ Ilulfunl /or eaamimiion nr the alnistinl tn"I'.meno aml pm of,ihe r.an h/nnmul ralcula.danv I alo .Aank.Dr. H. a,!\arom4eiorhn ail¢irmad .hec manurc.ipr. Tuae• 15eamsenta. N.atnherr, of na Nnmbeool nH with 'lumurs Rel.dve frequeuq Yl [rtwliaed-tund ia 0 7 ro [n.d'uud s . a, [rrWutnl-wad 41 s [trYli.w la 3 a.57 7.° frrWutM-tanerl 1S ItrwluwJ IS 2.25 P rN.Y.e. woL....taa~...Y..m~raYnutma/rrAYY~It• /w~W.M~rauw.YepnrYWrlwN.e.prn.rrYYY!•na n.~ W rurxr w W,,..r~. • 1vwJr.rY. VOL. s, 140, 6, MARCH Ig'. 19 76 0.08 0.66 0:°J
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.ABSTRAC TS ABSTRACTS INHIBITION OF TWO-STAGE CARCTNOGENESIS IN MOUSE SKIN WITH'B.IS(2-CHLOROETHYL) SULFIDEI CANCER RESEARCH t.,., . _ '. March 1976, Vol. 36, g. 1023-1025 Benjamin L. Van Duuren & ALvin Segal /CP/Ha.Swiss mice„30 temales/group; were given a sXn+ gbappiication of 200 pg 7,t2-dimethylbenzfa)anrhracene: lolbwetl 2 weeks later by three limes weekly applicationsnl phorbol rnyrislate acetate IPMA), 2..5 Mg/applipalion. in the " aceompanyinginhibilion espenmenls. sulfur mustard(SM; bs(2~chloroetnyi)sultida/ was applied at a dose oP20 wgh appiication during the promotionpnase, eilher on tnesame day as PMA, i.e:. three.limes weekly, onOn alternatedayst . f.a., twice w6ekly..The experiments wereeontinued,tpr 385. ''. days. Thrconlrallgroup; i.e... without SM, resulted io2Tof . 30 mice with a total o1281 papil'omas. Sisleenof~these micee also bore squamous cell carcinomas. In the two groups also -raceivrng SM, two or three times weekly. 2oi 30 and 110130 mice, respeelivelg borepapiilomas. Carcinomas were not observed in these groups. The inflammatory response of ; mouseskintoC'.ecombinrd.treatmentsatSMandPMAwas ' no greater than with PMA albne. . DEVICE FOR THEP.MALLY=INDUCED VAPOR PHASE TRANSFER OF ADSORBED ORGANICS. DIRECTLY.FROM'AN.ADSORBENT TO A GAS. CHROMATOGRAPH-MASS SPECTROMETER ANALYTICAL CHEMISTRY March 1976,. Vol. 48, no.. 3; p. 481 W. V. Ligon, Jr. & R. L.. Johnson, Jr. A davke h descrlbed which providesasanple means./ar aranslerring volatiles.adsorbed on a substrate Iromlhe sub• -~ - strata to a:gas chromalograph-mass apeclrometm.A.diw ' . mssbn ol the design and an evaluation o11he.perlommncs ' - N lerms ol:et/iciency and reproducibility am provided..A lael el the upper molecular weight limit for effeclivalYansfer fa described ICr a panicular cambinalioU ot lempaulurl, ' adsorbenl,andsampte. VoLa 6. NOa 6,. MARCH 19, 1976 . CARCONOGENESIS BY CARBAMIC ACID ESTERS AND THEIR' BINDING TO'DNA CANCER RESEARCH March.1976, Vol. 36 6 .' p. 1101-1107 A. W. Pound & T. A.. Lawson The tumor-initisting potency of Ihree simple alkyl carba, - - rnatesandmono-N-subslduledethyllcarbamateswasesam- -' ined in Hall strain mice. Thebintling ofi"C-labeletlcarba- ..,. ~ mateslo DNA was.measuredin Crackenbush mice. . ., Ethyl carbamate.was the most potenl carcinogen for.the. . epidermis, liver, and lung, foliowedlby'us N-aikyl deriva-... tivos. Methyl carbamate was without cllecl but n-propyl and' ~n-butyl were possible carcinogens. The ethyl esters bound: to a greater exten: to DNA rniijer and skin Iharvthe methyl. "' n-propyl, and n-butyl esters and.only.thisbrnding pers,sted. " A preliminary applica:ion of crotonmil increased thePele r •:+7~: -' Cf'akin tumors butJ not o/ liver Or lung tumors. It also in- ' --ereased meDinding ol the alkyllcarbamates Io.DNA in skin. ,. q . the increaseDeing grealest with ethyl carbamate. The bind- ... • _ ' Ingpersisledlongenntreatedlhanrn.non-crolonoil-Ireated .mice. .. . " MICROCOMPUTER SYSTEM FOR ANALYSIS AND CONTROL OF MULTIPLE GAS CHROMATROGRAPHS By G. Mario Bobba and Lee F..Donaghey AMERICAN LAI30RATORY ,; February 1976 : Vol. 8, no. 2,p. 27 The aulhurs have retxntlyJe- ....,~ veloped, . and tested. t mierocom- puter systern for, gas chromalo- gnpby wirh, snunnalicc realaimc sampling, data redbction, and mn- lrut foatures.° This article describes an extension of.. the single sas,. chmmutogmphy eomrollcr with substantial improvemcntt uf tllnl sydem su as.lo makc ptu_qhle.rlse simultnneous.conlrul.anA ieaHtime analysis: o(f monyy gas chroman. `raplss. Thee newmicnwomputer systcm is IiipJdy umuwutisn wnlr mediunr.ized,.mulliuscr systnnf:' New sultwarc, al Ille cx<cutireiNxl nf cantrol, is. Jescribed lor the performance• of tinx-slsaring opera- eions of the. micmcnmputer, and ausmcnled h.vdwam ~omrymcnH are presented which nuke prsuble the multiplexing of micrucumpmter programs betwecnn manygas uhru matnglaphs.
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REPRINTS IN LIBRARY Geisler, Jan' $zot,. 2bj,qnj,ex Chemia Analityczna 196Z', 12, 427-4'29' 6892 _ Lowenstein, J. M. Methods in Enzymology., 1969, 13, 513-516 easIT Reinart, A. Nesbitt, J. M.. Journal of Dairy Science. 1957, 40, 1!645-1646 6904 • , . Wollman, H. Pohloudek-Fabini, R. Pharmazie 16 - 1961 pp. 548-58 6'8J{p Van Den Berg, U. Hommes, F. A. Clinica Chimica Acta 1974,. 51, 225-232 VoL. 6, No, 6, MARCH 19,y 1916 EFFECT OF'ETHYLENEDIAMINETETRA- :ACETIC ACID ON THE COLORIMETRIC DETERMINATION OF CITRATES IN'BONE ''CHEMICAL METHODS FOR CITRATE AND' 1~ ACONITATE ._..~^~.Cf.;a+a .....;[. MODIFICATION OF THE METHOD OF SAFFRAN AND DENSTEDT FOR CITRATE IN MILK, , CHEMISTRY AND PHYSIOLOGY OF' SOME METABOLICALLY IMPORTANT ACIDS. X. INVESTIGATIONS PERTAIN- ING TO'THE ELABORATION AND ANALYTICAL DExERMINATION'.OF ORGANIC ACIDS IN PLANT MATERIAL A RAPID AND SENSITIVE MIiTHOD~ FOR THE DETERMINATION OF SHORT CHAIN FATTY: ACIDS IN SERUM Q. O O CD F+ CD
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r 'AQSTRACTS ABSTRACTS ' -nc . - µi:':iR84tv rr-(Ara[kYlaminomethv11-3.formamido-4'-h,v? ?t~' droxybenryl ulcoholi: hhuas•r, Knushr„ Murtknmi;.Masuo; '` " 7 daha.ht hrnu• Mnse linshiyasu' I6His:tdtr lapan...Kokai 7a,111;(1.1h (C1 C117C,AGtK), ttl'Sep.IJ7:i, Ap,d 7119;214, 18 " Bt•Ir 1974; . 8 pp:.. Title ai'Cs. 1(11 =H, lower alkyl, It. _phenyl . ~:.~ ti ~, t rro--~n+OMOC.NrNNCnwlcnrtpRr 'j' • . ., .R,'t e .k, . _ r ..., . ".. .,n.:,,, -,•a.: n m e ~., :%rat"S }{p] 'NCONN, ZtHjMR•CnMe:CN~~~n' ~.q0+'1 - u :'.ay J .. ... c~i]l : . ~ _": - . . l .. i ^~ L'.; ~L ly nni f It or without OH Imver a1kyL nr Inn•er alkoxys ubstituents, morphuhnn; n= 1'21 wereprepd• bt hvdn>Fenafinn.nf benzyl-= tr'' p'~-"prutected derivs. II (R'. R+ _H~ 1'hCN ..Z = C0, CHOH,,but Z CO when Itx_R+ = H; R! = phenyl with or without OH, r' PhCH:O; lower alkyl. or lower alkoxy suhstituents, morpholino). '"-1 were broncFmlilatnrs. Thus. 2.2 g 11 (K? _R4 =Ph(1H+, Z= CHOH. R.= H.,n = 2, R) = 3,4-dimethox;phenyl), prepd: from 4-henzy4nxy-3,nitm-u-bromoacetopLenoneand.N-benzyi-3-(3,? '4-di!methoxyphenyq-1~methvlp nopylamine in 4 steps, was ' hydrogenated n•ith~Pd-Cin EtOH to.give.l.4 g.101 .= li, n= 2, ~ . . ru.:i „qi.. .. . ' 84:5533+Jg Environmcntallysafe phosphinc-rclcasing fumigantt Kapp. )Volfgang;. Neubeckur, Fredegar; Brehm, Hans 1'. (Dcutsche6esellschaft fuer Schaedin sbeknempfunPm.h.H:) Gcr. Oflen, 2,414,518 1 (CL AOIN)., 0'2 l]cV 1975, Appr. P24, 14 548.0-41, 20 Mar 1974; 23 pp'.. Fumigant cmupns, eontg.PHarreleasing muterials.and oxidizing agents,ara packaged. in pouches.made ofnPHa- and water-permeable polymers- After - use,, the residual materials are inacuvatedbyd immersion of theT. ouches into water, thus eliminatin6an, encrrontnentall hazard.hus, the.pol.tc•ute(chinride). [900'-8G-2] pouch is filledw•ith - pAostoxin ['0859-73-8] and ehromwmlVA oxide [1333-82-0], and.issutured with a pol) ;(t^ny(alc:) [9002-89.5] yarn. R"-= 3,4'-dimetlioxyphenyll, which n•as t•om'erted to semifumarate. . Among 8.more I semifmnarates prepd; were (It, n, and Rz given): ;Me; 1. Ph; H, ?, p-tolyl; H;.2, morphohnn; HI 1, 3;4-dimethoxyphenyl. 84: 89528n Arylpyrirnidines, inhibitorsof platelet aggregation and! 8ronchodilators. Deh Angelis, Geraldl G.: Hess; Hans Jt E. (Pfizer Inc.) U.S. 3,905,042 (CI. 424'1l3 3,889,288. AppL 78;21G, 05 Oct.1970; 27 pp. Divisiom of (D.S About 100 py'rimidlnes L.IR = Ph, p-CiCcl1.,.2o-furyl, 2-, lhicnyl, "3-HrNCcHt, etc., R! = H. Me,.Et, Pr; R'-''= F.txN. MeNH, Bu:N, I-pynrnlidinyl;. piperidino; etc.) were propd• by'substttulion of 1 (R = C1)or treating.chlnrnhenmlhicnotrx'rimid;nesw•ithaminea `lnllowed by deavin.:. 'Chns. NCCH (.LkEt was treated with . 1'hAi;tlir and the IfaNCPh:CHCO":Et cyclirrd with HCONH6 to give 1. (R= Ph, [t' = 11. It2 =-0l l),., which was chlonin:ded with POCIi and treated with Rt_N)f tu give 1(R = Ph, R' - H, R='= EI:N): At. 10 4 p 11 Ilt = 1'h... Iit = H, Rr= Et:NI inhibited in vitropl:rtelrt' aggreeatinns hy99%a• At 600 mK/kgi. (It = 3•O:NCsH., Rf = 11, 12-'= RtcN) gave. 20% protecttorvagainst i gs. hisparnine induced lirunch,x•unstrictinn imguinen p VOL. 6. No, 6, MARCH 19b 1976 .., .:. :... ~ r .~:. ~ . ' ..~~.;,. ,-1. Matsumoto~ , ......c ......_. . 84: 58744w. 45.10,13-Prostatetracnmc acid derivnttve?. [`mhbe, Pterre; Frted, Juhn H Guzman. Angel (Syntez (U S.A.). Inc.) . U.S. 3,873n98ICIi 2G0 1GSU; C'07c) 25 Mar 1975,Appl. ' 377,108, 0GJu1197a; 25pp• Ali6mcprustal:landins(Iand!Ililt ri 5 H, Cix alkyl, salt mnret..'.fit,.It- II. ISt, hte, 1'r Rs= 011. ifidhifid OH Hh M P RRt " estcre or etere, 114 =te,r; nr'= 0; a = 2-9) were prepd. via \Viltig reactions of the aldchyda group in , 111, lirnwed by reaction of 4-pentvn t-ol with the resulting - lactuneand conversion of the rosultmgacelylmtic pnistaglandina aat C_CarfCHiJ:Crlrn (cN2)P Mr fo.I and II: A variety of standard proceduresfor prostaglandin synthesis were utilized, includin,P, enzymatic estcr-hydrolyses; . proteeGve-group.chem., isomer sepns. etc. Iland II have physiol• activities similar to natural prostaglandins,. e.g., as ovariam cycle- regulators, bronchi dilatars;.antilivper:ensives, and sedatives. 84: 39G63c Promising pyrethroid and organophosphate .~ i~nsecticideswith low mammaGan tocicity.. Sullivan. W. N.; . Schechter, M. S.;. Cawley,.B. M.; hennedy, JI (Agric. Environ. Qual. Inst., ARS; Bel(svdte; Md.). 4fm ; Cn+mrt., C'hem;. Spec. 197.5, 51(10). 44-6 (Eng). FMIG'3J>97 Pm-plienoxy'benzyl-cfs,= Imnx-(t)-(?:2-dichlnruvmyD+2,2dimethvlcycloprupnnecarhoxylats..152645-53-1] NltUC 147[51877-7AM], S.259.9 [2f,ut12-80-2], - rexmethrin [10453-8G-81•SAN!'.l97[O-[G-ethosy 2-(1-methy1= ".eth'•1)-4-pynmidinylilQ.U-dimethl•]~thnsphorothiiunte [38-60-63-81 ., and Si7N 1 2011 in aerosol nr ust lurmulatronscontroll de .. houseflies, mosquitoes, cockroaches and other insects.:The • compdst have Inwmmnmalian toxicity. 84:5873flb. 15-Substituted 9-ozoprostadicnoates. Roussel-= UCLAB Fr. Demandc 2,255,888 ''. ICI. A61K, C0-vC),. 25 Jul 1975,. Appl: 74 00,044, 02 Jan 1974; 12 pp. The Grignard Mr Ca}Me'~. ~ u. a I 11) reaction of a mixt. of the 5:9;13-prosta6rienoale. (1) and its 8,8,13-lriene ismner with, hlcl andCII'-:CHlir gave the res't~• . 15-substituted 9-uxuprostadienoaates(11, R. = Alo; CHx:CH) i which showed hypotensive, bronchudilatur, and.iteum-contraeting activity. . .. R4 -na . .~ .. " .~_ . .. .J R°
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'_ABSTRACTS REPRINTS IN LIBRARY ` Sekhon, I@. S. Ahuja, Sandhu, R. S. >.,,. Tndian Journal of Nutrition „.::.and Dieterics - ;1970, 7, 243-246 690 3 iWogrinz, A. ` , Monatshefte fur Chemie , 24, 245-25Q; 1903 (i905 Egli, R.H. COFFEE CHEMICAL COMPOSITION OF RAW AND - ROASTED PEANUTS ;_. . .. , ,. , NOTATION OF ISOPROPYL AND DIMETHYL OXYBUTYRIC'ACID: .. .. .. ..... .... '.; ii .`.':. . . . .... -. .Woodman, J. & Giddey, A. CARBOXYLIC ACIDS OF BREWED International Colloquium . on the Chemistry of Coffee 3d', Trieste, 1967-Proceed.1968 g90(S Yamashita,YM.' Journal of Organic Chemistry 23 (1958) . 68ei7 Frazeur,. D. R. Jourhal of Dairg Science 1961, 44., 1638-1643 VOC, 6, IVo, 6, MARCH 19, 19T6 SYNTHESIS OF CERTAIN HYDROXY CARBOXYLIC ACIDS RELATED TO: ISOCITRIC.ACID. METHOD FOR DETERMINATION OF CITRIC AND LACTIC ACIDS IN DAIRY PRODUCTS 1 O.• 0 O . ~D O O
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ABSTR.AC' 1 S REPRINTS IN,LIBRARY 6883' ALMQVIST, SVEN-OLOF ENZELL, C.R. WEHRLI, F.W. - ,Carbon-13 NMR Studies of Labdane Diterpenoids .;..:... Acta Chemica Scandinavica 29 1975 pp 695-702 HOffmann, D. Vais, J. t American Health Foundationr White, J. C. D. Davies, D. T. ""a.; -.. .. Journal of Dairy Research 1963, 30, 171-189 : .. a' QUANT•ITATIVE DETERMINATION OF CARCINOGENIC VOLATILE N - :WITROSAMINES INiUNAGED CIGARETTE .SMOKE THE DETERM'INATION CITRIC ACID IN MILK AND MILK SERA OBTAINING QUANTITATIVE INPORMATZON FROM AN'SEM EQUIPPED WITH AN ENERGY-DISPEIZSIVE X-RAY ANALYZER .. Scanning Electron Microscopy: Systems and Applications O 8 1973, 238-241 G C0 ~ (1879 O ACETO,, MARIO D. Pharmacology 13 1975' pp 458-64 WOL, 6. NO. 6, MARCH 1'9. 1976 The Antinicotinic Effects of' Drugs. with Clinically Useful Sedative Antianxiety.Proper.ties
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-ARSTRACTS ABSTRACTS , , . ... ,:5~. ' .. 84: 5,it93c~ Itcevaluatinn of the oPticaU titrations of the J30.."and 455 pm chromopAnres,uf ethvl usocymidecomp]exes of ' mamtnalianhcpaticcyUxiirnmcl' t.0. Pets,tch,J; hlannoring.,. „ G. J• (Albert Einstein Culli. Med Yeshiva Univ., Btonx N, `Y.). Mof: Pharrnucnf. 1975. 11(0), 818-23 (Eng)i. Acomputational meth,d is presented from which one may calc. the_e plf forthe pH-induced spectral changes of.ehe 4a0- and 4fs5-nm~: ',. ehrumaphnres of Et isocyamde complexes of rat7liver microsomall 'eylochromeP450:. For lhee rat liver cemee protein from controll ., and phenobarbital- or 3-methylchoianlhrene-treated auimals,. ':j:the K for the loss of the 430 am absorption was equal tolhe. ,- pl< Por the.gain of thoA55nm absorption, establishing that the 2'.• ~: ehromophores are in pH equil. with one anotherinall 3 prepns• : r;This equil. was maintained even when the change in pH'.occurred -r after the add'n. of Et isocyanide. Apparently, the appearance of 430 nmabsorption after the.addne of Et.tsocyanide.to reduced -;: eylochrome P4500 does not necessarily reptesent conversion of thrs cytochrome to cytachromc P420. :1 84: 55101y Ring- and. N-hydroxyloiion of 2-acetamidnf- ; luorene.by rat liver reconstituted cytochronte P 450 enayme syslem. Lotlikar,PrabhakarD.; Zaleski, Kathleen (Sch. Med., TempleUniv:, Pbiladelphia: Pa.). Biochem. J:. 1975. 150(3). .661-4 (Eng). CytochromeP-4a0[9035-51~2] and NdDPII-= ' hdt [9023 034] fti eytocrome c reucase.-racons were both s.. required forop timum N-and rmg-hydtoxylationof'2-ucetam= -. idolhrarenei53:-9G-3]I, in a reconstitute& enzyme system from. , rat.liver microsomal fractions.from both coptrol andi3-methy= Icholanthrene [56-49:-5]-pretreated (100. mg/kg, i.pJrats• Hydroxylation activity was detd. by the source of the cytochrome P-450fraction; that from prelrentedLanimals was several times ~: more active than that from controls. and'4haCrn the reconstituted - systemss wass greater than that in the resp. whole microsomal 'fractions. ' .. ., - , 84: 5550Jg Ligand binding.oforfianicsulfidestomicrosomal e~•lochromc P 450: Naslainzcyk Wolfgang: Ruf, ilansN.; Ullrich, Volker (Ihp• Phssiul. Chem UrnvS:nrllndJ. Saarbrucvken, • Ger•): Eur.J:.Bfarhrm: IN75,. GO(t) Li15-20. li ngl: Octyl b'te, Bu Me . and pcntamcthylenc sulfide reactedd with 50% of oxidiacdcytochrome 1' •I50 inliver micrnsotnesfrnm phennbar= bilal-pretreated rats by fnrmatiomof optical difference spectra with, maxima at' 4:1:i nrn and 552 nm anll concw mlan0 shifts in the electron pnramat,netic resonance spectrurn.. Itedn: h,v NA~DPH or No..dilhinmtc.yrelded ati,urGahsnrptiun.lamd,at 4-19 nmvrnd a.and' It hundv at 57anm and 545nm„resp: •fheJiimnd metyrapnne and tbesuhst.rnle a oxt.•tnc cnmprlitrvtdy'inhibited the formation of lhe.e diflbrenn..speclr,r ouJ penlnmelhvlrne sulfide was a strong.compelitive tnlubitnrr of the (/dealky!atiun of 7elhnxyrcmmaoin. Thus, thrre is a diirck.li;;nnd hindiug nf theatdfrdes Incylurhrnmo I' 45U withcuncomitmu..hineking.ot thehydruphuliie sule4retc. binding site. Wune sulfidrs,didm4 interact ax.licandsbut as sutrrtrales, in rariatiun. huwever, with thcwmrce of mirnvcr,mes: 84: 39527m Hepatotoxicityof vinyl ehloaide and 1,1-diehl= .- oroethylene. Rate of mixed.function axidase.system. Reynolds, Edward S.; Moslen,. Mary T.; Szabu, Sandor; Jaeger. ... Rudolph J.; Murphy, Sheldon D: (Dep. Pathol., Peter Bent . Brigham Hosp., Boston, Mass.). Am. J: Pathof• 1975„ 81(l). 219-36 VEhg):. CHz:CHCL [75-01-4], an occupational carcinogen, produced acutetiver injury in rats pretreated with phenobarbirnl `50-06-6]I or ArodHfor 125•! [11097-69-1].. Injury appeared reiated to morphol. changes imthe endoplasmic reticulum. The degree of injury, as indicatadi by elevation of serum enzymes derived from ttre liver, wascorrelaled.with the magnitudeof : induction of pKochrom.eP-450 [9035-51 :] andits-redn.d by . NADPH 53-57-6]. Hepatic inluryf'olluwing, exposure to CHx:CCI} f 75-35_4]' differed significantly from that caused by CHzCHCland appeared to involve plasma membranes, mitnchondria, and, chromatin without', affecting, thee endoplsmic reticulum. Inductinnof cytochrome P-450 appears too protect against :CHzCCIz but not CHs:CHCI. . „ - , . t 84: 392lI6f Effectof aromatic nitro compounds on oxidative metabolism by cytoehrome P-450 dependent enzymea. . Sternson, Larry A:;. Gammans, Richard E. (Sch..Pharm., Uhiv: •Gear$ia,. Athens; Ga.). J. bfed: Chem. 1976, 19(D, 17a-7(Eng), Nitrobenzene [98-95-31„ p-nrtrobenzoare [62-23-7]i . 2-mtro(luorene [607-57-8] and'1-nitronaphtJtolene [581-89-5'' , . inhibited theaxidm.o( type 11 substrates(andine[62-53-31 and zozazofamine. [61-80-3]) by cytochrome P-450 dependent. . enzymess in liver microsomes, butt the arom: nitro compds. did.d notaffecttheoxidativemetab, of.type.I compd§:Ipuxobarbitat'. 156-29-11 and nminopyrene [58-15-1]): Hihetics, ofthe-f inhibition indicated a nonlinear noncompetitivee effect„ usually' indicative of a mixed mechanism of interaction withthemicrosomal drug-metabolizing enzvmes•. 84:..555I9r Heterogeneity of.cytochromaP-450 in rat liver mierosomes: selecti~ve interaction of inetyrapane and ST.F 525-A with different fractions of mierosorrtal cytochrome P-450. Grasdalen„ Hans[ Backstrom, Danl. Eriksson, L. $, Goran; Ehrenberg, Anders; Moldcus, Peter; Von Bahr, Stockhofln ~rSwed.j: SFEBS Getl t1it1975a 60(21~t29i 9 c(En ). diph nyvaterate (I)aand mely'raponea(II)ereact seteetlvely2 with~ dif(erent.fractions o0 liver micrasomal cyKochrome P 450 (I1I).. • The reactions are independent of each other, strongly indicatingn thee presence uf?2 Jbrms of thee bemoprotetn. Phenoharbitol. treatment of rats induces the formation of a.form of III which binds11 lightly and onlpt to a much lesser extent.eomhines with I. 111 can be further divided'intoo subfractions w•hichdiffer in theirbindingr specificity for li lidncaine, and camphor• The relative amts. of these subfractions are also altered bypretreatment of animals with~ phenobarbiloli C 8 C CO ImA
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E__:ABSTRACI"S _ REPRINTS IN LIBRARY ,6'88g BURCKHALTER, J. H. SHORT, J. H. t :, Journal of Organio Chem. 23 1958 pp. 1281-128'6 . 6884 Braun,. Ludwig Monatshefte fur Chemie p. 207-224 , v. 17, 1896 6389 Grob, K',. Chromdtographia. 1975, 8, 423-433 6894 Roboz, J.. Colloque Bogota' 1973', 6, 8:1-88 r VoL, 6, No. 6, MARCH 19, 1976 Synthesis of'Nicotine Analogs• THE EFFECT OF ISOBUTYRALDEHYDE ON MALONIC AND CYANIC ACID :'..,:. . ' r« . , _ -:;-~ THE GLASS'CAPILLARY COLUMN IN GAS CHROMATOGRAPHY..A TOOL AND A .TECHNIQUE CONBINED~GAS!CHROMATOGRAPHY-HIGH RESOLUTION MASS SPECTROMETRY FOR IDENTIFICATION AND STRUCTURE ELUCIDATION OF ORGANIC COMPOUNDS IN NATURAL PRODUCT RESEARCH,
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Almqvist, Sven Olof Andersson,, Rolf Shahab, Yousif'. ' Olsson,. Kjell Acta Chemica Scandinavica 1972, 2'6, 3378-33'80 ABSTRACTS REPRINTS IN:.LIBRARY ' ee's~ Lanzillotti,, H. .Wayte, A. R. Beitrage Zur Tabakforschung 1975, 1-23 888 2 , .- Pr©~,~ AFGHAN, BADAR K. LEUNG, RICKY RYAN,,~ JAMES F. :Water Resea=ch 8 1974 pp. ' 0897 Tso, T.C. Andersen,. R.A.. 'ONE DIMENSIONAL GAS CONCENTRATION PROFILES WITHIN A BURNING CIGARETTE DURING A PUFF r LANTHANIDE-INDUCED PMR CfIEMICAL SHIFTS IN TRIGLYCERIDES 78I9-9'5'. AUTOMATED FLUOROMETRIC METHOD FOR DETERMINATION FOR CITRIC ACID IN SEWAGE AND SE~- AGE AND SEWAGE'EFFLUENTS TOBACCO Encyclopedia of. Industrial Chemical v. 19 1971 p. 133-160 VoL, 6, 1Vo, 6. 1hnRCH 1!9, 1976 Analysis S O ~G. O C3 . 4
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• ABSTRAC i S %'+ ~;.'83: 49835z L8;9.6-Tcttnh-vdro-l,9-<tiimrthyl-2,6'-dloxopurin= ' ~ ~2`r7.-ocetate of.2-((2-dimethy:amimoethyP)(p-mrthaxyOenzyl)c - `-'.minb]pyrrdi'ne. Laborntorios Made S: A, Span. 3'J9;671 (CI. C07D), 16 Nov 1974, AppG 11 Feb 1972; 5 pp. The title d U) [57989 74':-I] w ~tY" eom d b th r cti f l 2 -t 3 t= •- p - as prep . e ea on o , ,G e l -~ arah dro-I 3-dimetkyt-2,6-dioxopunhc-7-acetic acid with, 2-((= ~2-dimethylamihoethyq(p-methox)benzSqamino]pyridihe QIII ? • rand was useful as an anttkiistaminic, bronchodilator, . diuretic, and 'b5 wrdtosGmulane.. •. -- 1 tr't ,r. t r avYiaB9 . 84:49R91x ISronchodilhtnr eompnsition. Comer, WilliamT,; (Mcad.lohnzonandCo-). U.S. 3,919,424 (Ch <'424 916; A61KA ILNov'1975;Appt 22<J;202, 16Fcb 1972; . 4 pp- Division of. U.S., 3,801,631. 8runchuddntur crompns; contg: a ... .S~ L.N WrsarNN- v'YMIeMICNrNNCMerCMrR, 1 lY.i ,. 10 '..: 1 SJ:.n..{'{l:. ~,I f:: t'y, MJ9184 (1) or itssalts '(e g-• f HCI(Il) [t8241 28-Oh 1 tuEhionate [52159-t7-i]] were.pre{•d h•tvinX.2 20 mcP./kg daily .' dosage and possessing analgeslcand anorezigemc activity. Thus, ..:J a capsule formulation consistedi ]I 0:5_and lactose 159!5' g with each capsule havinq.0.5 mg.f1,. 84: 49R74m F:nlhal'.pimctricand Hcennumetric detnrminat.inn of somcnitrugcn-wnt,tming basca's and'physioluGicntly active alkaloids. linrk li S.:Crrme J. (Dep. ChumAppI: Chem:, Unn Salfnrd S:dfnrd/LanaEnXl.)-. Pruc•. Suc. AnaC • 'C'hcnn1972, 9(9),.1h9.91 (lrnti) livcntythrwnitrngenuus [ bases (primnry, secondary, tertiivy,.and yuaternary) includinp4 pIrvsiul. actice.alkalnid, were anzh•r.ed br. pptg,.thrbasewitha -.known and excess amt- of. Noletraphenylbnron and detg. the excesalVa tetrap6enylhoron by measuring the heatt release upon addn.. of KCI to farm Ktetraphenyibormr. All compdk,& were deld.. in the range 0.03 x10s to 0•7X' 10.1 moles with results wilhim1S% off thcor:. value. The std- dbvialion of the method ' was 0.27 mg. . ' . ~.84:'.5B757qAbsolule con~finuratiun of (+1-trams:-chrys:r=~ . nthenric acid. Crystal strneturc nnalysis of ap-brmnonnilide , derivatira. Camerun \,Fnrl es: Fcrguwm Ger r U l4onnnwa,v, Christine (Chem. Dtp. Chutt6lt loe, Gl.utaw,. Snrt:). J,. -' Chcm, Sue, Pbnkim Tronv, 2 IJ. n, (14);1507. 8 (EnX), Ve Mc MeeCsCNAaM 1, a.aM tti. My -a/ctny v. Thr abe. vonfiguration of (+) rrmnJirpannthrmio etid 11) was emdirmod as Ili,lR 1•v a:1 dim, n iunal x r,rv mvd. of t'he. D-brmmonndldc 11 ustn:; Iii1v,N,ts mmntalous di.slM•rsfim melhorl. VOL. 6. irlar 6, MARCH119, 1976 I84!54200t Effect of the variation of bibod p1Ion the bronehodilator effects of saf:butamol in cats. Tran,Mrs. hL• A. (Lab. Yhysioll. Appl. Pharnmcoh, Tuulouse, Fr.). 7herapie . "1975„ 30(4), 565-71: (Fr). In anesthetized' cats,, metabolic'c or respiratoryalkalosisy enhanced the bronchodilalorr activity' of sufbutamol' (I) [1R559-94-9] while acidosis decreasess it. Propranofof L515-66-6J inhibited the effect of alkalasts ;, .s .,.: , , •84: 58751w 15-Cyclobutyl pirostaglandin analogs. Kurono, ~' 6fesayasu; Nakai, Hisao; Muryobayashi„ Takashi(Ono . Pharmaceutical. Co, Ltd.) Ccr. Offen. 2,510;8i18 (CL C07CD, . r-C08B; A611i). 18 Step 1945; Japan. App1. 74 2$Sa4. 14 Mar .-' 1974; 97 pp. Approx. 70 16:16-propanoprnstaglandin analogs :. and intermediates were prepd, bv the Wittig reaction of --.(Me0)fP(O)CH2COR. (R = 1-Ca-e-a[kylcyclobutyU with cyclo= - pentanecarbnxaldehyde or 2-cyclopentene-1-carboxaldehyde derivs:. Thegastric juice secretion-inhlhiting and bronchodilator properties of. the products madee them useful in the treatment of stomach ulcers and astNma: ... .loa:.rr•. u • .. . : .. '84: 53709d Aiiway resistance or peak expiratory Do+v-volume ' loopss for thc pharmacological investigation of bronclwdhatiugdrugs: Cnmaud, Ch.; Vanuxem. P.; Jelpierre, S.; Oroliek, J.;. Coutant, P. (Lab, Explor. Fonct. Recpir., llop. Salvator,Marseille, Fr.).. J. PhannacoL Cfin.. 1977: 1(2), 111-19 (Fi•),. Imbcalthy volunteers, inhalin~ SGH 1000 [222i4-24-6] (120 Ng) or satturamof [1S3a9-9:-97(fJ00 w;) de:rca;^d air•ra,y resistance(HAw) and increased max. expiratory flow Ih1EF):. Nocorrelation „ was obsd. between thevarihbles measured. lttw appcarsto be , the better methortforstudying the effects of'bronchotlilaton. 84: 42181t. ltapid stcam distillation method for estimation ofavailable:nitrogen in soils: lrutnavaru), M. R. Srinrvasan, -- T. R.; Morachan, Y. B. (Uep. Agron.. Tamil Nadu 4~ric: Univ.,. Coimbature, India). Madras dSric. J. 1975, 61(91, 6.15-18 (Eng)• Steam distn. method off detg. available Y[77'27-37-9[ with 5gm of air-dried soil is described using alk. permanganate soln. Thee distn. methud, is rapid, accurate, precise,, and - economical., . . .. 84: 58911y llydroxy[-substitutcd: 2-cliloro.n(tcrt-ti}jtvl= nminomclltyllbcnzylalcohols.. Yuzuru. Y•nruamotoc IiidCO. Katu: 5aktc, Kurata; Uanmori, \rhidc IH'oknriku Pharmaceutical Cu_, Gd.) Ccr:.Offen + 31,3~17 ICI. COTC, 1611U, 27 Nnv 1975. .JJapan. App1. 7453;903, 16 Mnv 19;4; 8 pp;. '1'heaimtzyl • M06 CNa11q6NrNMCNar' I ale.cicri.s. f(3-;4-„ or 5-011) were prepd. bv the oxidn, of C1fHOlCclliAc with SeOr toCl(1101C.;61aCOCHf~, whirh reacted~rith Me;,C1Fl_and Nirfllh to give the desired.pruduct. I were . uneful'.as brnurhntlilators Itm.d:ltal.
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:~ 84: 57l56s Do caebonylamino browning reactions occur in :, viva Dilthrd.Cura 1; Tappel. Al L. (Dtp• traid Sci. Technol.. ' ' d ( .. Univ. California, Da.is, GdiL). J: Agric. Fnnhem.. 1976. •• 2A(7); 74-7 (F•ng)• Investigations by. Ruorrxente. measurcmentss of carbimylamine browning prtalutts in viro.,mdo studies nf the. rfateuf exugennuslvpnxlucerlgluc+nu-glycine browned prudurts -.injected ihtn or fed'.tn r:rtawere dnnc. M+clcl systems of phyainl• 'cuncns off amino acids and carbohydrates at pH 7.35 undergu. .brnwning,al 37 and 500 with fiurnation of uv aInnrliing ,cnmpds.. -.-and campds, with tlunrc•scence s'uwuaC characteristics of. 't aar&mvlamine Schiff bases. Similar Iluuruphnres werenot. ~deteeled: in dialyzatesuf fresh or incubated humani plasma.. --. Fluorescent browned gfuuose[5p-99:-7) glyrine. [56-40-6] mixtc fed to rats via a gastric needle were not detected in - plasma or urine 3Ar after dosage:. (t+Cl labeled gtucose-glycine ~ browned productss were efficiently removed via the. urine• an sv. -~-of8a:7%.oftheinjectedlabel.lieingremnvedIry48.hr• Allhough. ' ditidhtid f thf Dut . tto,rec' evence wasonneore presence oruescen. ' carbonylamine browned products invivo, their formation was~ not - ' di -sproven: e 84: 49976w Apparent density determinationn of porous materials by powder pycuornetry. Korta, Andrzej; Klinik, . Jerzy (Sch. Min. Metal., Inst. Energochem. Phys. Chem. .* Sorbents, Krakow;, Pol.). Chem. Anal. (Wnrsaw). t9751 20(51, .7079-84' (Poll- Zn dust was used instead of Hg as a mediunrfor ', detg. apparent.dp of porous materials. The method..did not need ~ initial degassing of samples andi permitted lhee detn. of the .apparent.d.of~arains<0.5~mm.~. , .., ,. •. AJanowski 9t 57313t Charactcristics of a fermentatlon process and 8 - thecontrol.of interrelatcd.variables:. Shu. Ping (Rachelle Lab,, Inc., l:ongReach,. Calif.)• Ferment. TechnoL Tod'a.~,. ~Proc. Int, Ferment. Symp., 4th 1972, 183-6 (Eng). Edited by. Terui, Gyoxo. SOc. Ferment. Technal.,. Jpn.: i3saka, Japan. A review with 8 refs. 85j Recent developments in thee documentation of 84: 42 5 - spectrochemical.data.Jones. It N.(Div:.Chem., Netl: Res,. Counc.. Canada, Ottawa. Onl.):. Gener., (7bmpii., Ettn!•, Dixseminarion. Data Sci: Tcchnot:, Proc. Inl. CODATA Conf.,, 4lh 1974 ' fPu:x 1975), 104-8 (Eng). Edited by Dreyfus, Betrand. Pcrgamnn:. Oxford, EnghA discussion um the, documentation of irspertra data ispresented: ,. . 84:42080r Automation of - uronic acid determinatioa by thecarbazolo method. Applicationn topectic substances.. Thibault, J:. F.: Robin. J'. P.. (Stn: Biochim. Physicochim,. Cereales, ]nst. NatC Rech. A ron., Macsy,Fr.): Ann. Technol.. Agric. I97S 24(t). 99-110(r), The method of hlcComb; E•A., andMtReady, R:Mi (1952) for detg. uronic.acids by conversion to.5-formyifuroic acid which condenses with carbazole, to form a.a purple complex with absorption max. at.520-30 mn wasadapted to.automated detn. with an.Auto-Analyzer: Pectins were detd.. by preliminarv hydrolysis, with H2SOt after nonautumatedd deesterification. The sensitivity of the method. was. 2 ag/mI„ better than was obtained, manually. Ten samples could be detd./hr after preliminary deesteritication. The. method' wass adaptable to Setn. of pectic substancess sepd. by collrmn, chromatog, . . VoL. 6, iVor. 6, MARCH 19, 1976 84:'599711c Volatile heterneyclic compnunds•in the reactiun ` of glyoxal with glycine. Velice.k, •/nn; IOa,idek, •lir4 Cuhruva. Jana; Kubclka„ Vladimir (Dep. rrasl Chem. AnnL, Chem, Tech: Univ:, Prague. Czech.). J: Agric: Food Chrm: 1974, . : 24(11, 3-7' (Eng). The basic fraction of thrvnlalilcsfrom an equimolar glyuxal-glyeine mixt: hcntcd' under re0ux for 44 hr wn: separated by gaschromatog Carb+m ls wtre • t d t th i : y com cr o o e r ;~ 2,4-dinitrnphenylhydranmcs andiscparatcd Iby.lhim layer ehrmqano;. - Individ l uo a+mponents were isoltdlld b ae nnr anavzey ma.. Kpectn,metry, uv; visible, and ir speclrumt•trr. I'yrazine, 116. .. 'l,5-dimethyl, 2,6-dimethyl6 trimttlnlpyraxine an& 2 rruli : py . aldehyde were identified. CH,O' . was fmmd as the nnlv carlxmyl' groupconqG reacti IIzNChXl1Od un product.: w•ac.ynthc~ixr end the formation mechanism of pyrazines and pyvule wn. presented. " :,'r.. .,+• .... ...... ....• ,.. . .84: 58520vReduction of acrolein to nllyl alcohol by exchange of hydrogen with cyclohexanol in gas phase on a magncs6unt '6xidee catalyst. Gajewski. Franciszek; Rakoczy. Jan, (inst. ."Chem: Technoll Org., Politech, Krakow, Krakow, PUI.1: Pr_em. .. ChemI975, 54l7)',.391-3(Pal). Thecatalyst•w'as.placed in a ;.z quartztube, and at.300-428' was fed' aL.a rate of 11.7 mole/hr, 'witha mixt contg. acrolein (1) and cyclohexanol (11)' in a molar ratio of 1:3, 1:4, and 1:5. At 400" the conversion of 11 was 13.5. 19.6, and 15.3%, resp. Thecataly.t activity as.well as selectivity decreased as the reaction timeelapsed, due wpolymn: of allvl alc. and I on the catalyst surface.. Thermodn. data for ttie reaction was given. - - A 1V. Jackowski " 84: 49513t ChcmistrySafetyManual,.1975/7G. (Sicherheit:fi6el ., Chemic, I975/76) Roth,. H.; Ruth, . L. (Verlag Modurne Ind.: ;Munich, GerJ,. 1.9751 224 pp:, ' . 84'. 42047k Factors determiningehequality of gelled products. Segal, B.. (Rom.).. lnf/uenta Prm•esclor Tehnol. Culitutii Prod. Aliment.. 1974, 1, 205-22 (Rom). Ed! Teh.: Bucharest, Rom. A review with 6 refs. on chem. compn. and' characteristicss of nectin f9000-69-5]gds 84: 57971f Information theory. and lts use to analytical ehemistry. Fitzgerald, J. J.; Winefordner, J. D.. (Dep. Chem., Univ.. Florida, Gainesville. Fla.). Rro. Anaf.. Chem:. 1975, 2(4), 299-316 (Engl. Information theory, and math. equationsOor information as relevant to.anal. chem., is presented. . 84:.42098x Delciminatiou of'residues of carboxylie acids (mainly galacturanic acid) and their dcgrceof estcrification .Ih industoial', . pectins by colloid titration svithCaftb9oc. Mizote, Atsunubu; OdaRiri. Hiroyuki; Toei, Kyoji; Tanaka. Kazuko (Sansho Co. Lld,,: Osaka. Japan). Anakxt (London) 1975, 100(1196),822-6 (Eng)•. Using,added nitrosodiprnpylamine as an internal. std., the sample in. hexanewas sepdt into, 2 fractions on a column consistingof.3g basic A1~0a, activig• [l, 3 `neutral AIz0i, activity Ifl, and 11 g anhyd. Na_SOr which had tieen prewashed! in E120-pentane (1:1) before bakinp at 200-20° the fractions were sep. oxidized, . w•irh9 ml CFzCO_H and 8: ml 50%Hz0i, then the final concentrate impentane was added too freshly prePd. AL,0i.calumn and eluted.successively.w•ith 5,.25, and 80%ht20 in pentane and finally 100% EtsO: Theeluate was collected in 5 nil fractions w•hich.h were sep: analyzed. Specific nitramines were found inspecific eluate fractions. When a nitraminee was detected by gaschromatog: electron capture a further gas-chromatog. step was carried out onn an electrolvtic cond. detector. The procedure minimizes interference and increases specificity to 5 pglkg• ° 00009174
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ABSTRACTS 'ABSTRACTS- NATURE ' -''March 11, 1976 °' Vo1. 260, no 5547 I p.134 i Infh3enee of magnesium on nickel toxicity j= ~Tlrz inRUelae of cakbsmin amdiorating hnvy mnaLte Icily ,.;j. Waardsplanls-swell'.known-Thepossibililythacmagnestum _; mlElit possm siiniluryropenies, if trsa ksser extcnl. has been ' Iagely ignoredby aolagists.ahAnugh there arnindicanom. ~.) .. I in elu literaturrthat such is the case'-l We here reaffirm the ' , _ , eRect,andpuintoutitsecnlogRatsigni6cance: -~^+m~~.' ` We investigated the growth ofoals (isvrna saHro t•. var.~• ` Sehm) over a wide range of'nickel,and, nugnesiumconcea- trations in water eulture. W2e herc repon' in detail one of our ... " experina:nls in whRh:oalg were grown at',masnesium kseh of " 1.25,.23:5.g and 7.3'msl combincd vrilh nickcllat 0 and 13: . . >. p-0:m. The oatssvcre.pregerminalasd and tramferred as seed- : . bngsto containns fOkd with Ib.l or cullurc solutions..The tulture mlwium.cemaincd, in addition lothe esperimentaAy. 'y varitJ Ihels or Mg50, and Ni(NOaL. I mM' NH,H.pO., ,'.6 mM KNOe• 0:3 mht Ca(`IO,)r,. 7mMl NaSO'„ 0-f mM NaCI, and, asmrcronalrients; 90 pM KaFtEDTA, 46'. pM _H9O„ 9.1 pM MnSO., 0.76' pkt znSO„ 0.32 pM CuSO:, -9.1 pks (N11,I.Mb;O;,. The pH ws adjusted to 5.2 at each '° wecklychanBeofeuhwesolution. . , . ~':V .1~~;.;::'l+. a EVALUATION OF' VITAMIN A ANALOGS' IN' ..MODULATING'EPITHELIAL DIFFERENfPIATiON' OF 13-DAY CHICK,EMBRYO METATARSAL SKIN' CANCER RESEARCH March:1976, Vol. 36, p. 964-9'7'2 Lee.J. Wikoff, John C« Peckham et a1 Seventeen vitamin A'compounds were:evaluated in organ culture for. activity imaltering: epHhelial differenhatlon of melalarsal'skin explants from 13-day+old chick embryos. , The explants kerahniaed in 6IIp.B days and. wlien cultured in the presenceof p.retinoiC acid fRAl::innibition ofkeratiniza- tion occurred and.a mucousmetaplasia developed.. Acyelopenlenyl analog of' retinolcc acid was approxi- matesy t0-lold more ellectlv9 mamRA inprooucingmucous metaplaaiY. Six other analogs exhibited aboutt the same activlty as. M','trimethylmethoxyphenyl analogof retinolc ;" aclo,. n-relinoic'scid. 13ds•retmotc acidl.methyl retinoate, ethyl relinoate. and N-elhylfelinamide:.The Icflowing 5 vb lamin A compounds were about.one-ICunh astffectlve as RAthe tnmethylmethoxyphenyl analog ol ethylietmamlae: the phenyl,analop of rebnmc old. I/ie, tnmllhYlmetnCxy phenyl analog of ethyl relmoate.. p-retLnyl acetate, and retrnol. The turyl analog nl'.rchnplC acid and N.N-dlelhyl- rettnamide were,approximately one-lenlh and nne-hlteenth less ellectne ihan RA in, InlMblting keralrflQal,bn. The analog, narotmyl acelate. was about one-hundredttt as eflecove:as RA and Ine'Dyndyl analog o/iretlnorc acid 12.5.a10• ul did noeinh+bd'keranmzavon. Since ma propaety of altering epilhelial differentiation mrybe alundamental raguirement fortheprophylams and/or treatment of mallgnant epthehm:leslons-thisaystam can be used to determine whesbesthe new synthetic analogeof Yitamin A are acliin in modulating >pilhetul dillarenpahon. :WoL, 6, NOe 6, MA'RCK 19, 1976 ACCURATE TEMPERATURE CONTROL ,IN'FLAMELESS ATOMIC ABSORPTION AMP:1t1CAN LANVRA77VHY March 1976, Vol. &, no. 3 pe 59 L .B: R. Culver & D. E. Shrader T HE USE of graphi2 fumace atnmirsrs for routine atomic absorption analyusof trace met. al h i d . s. as ncrease enormuusly during Ihe past Few years. Several types of furnace atumizasare cumnter- . u. Y a.audma. ... : . , Oae o0thes< devices 6 the Varian-Techlron carbon sod' atomizer (CRA): Tiu:. CRA modcl 63 h.ssbeen. Javailable and extensively used for over four. years. ~ Althougli.tlie CRA hassevenCadvannges'becausc.uf its . design, some pmbkms havebacn encountered over the . - yearswith Ihis's device and otlmr lypesof grapltitc , f A' urnaces.ccumle Iemp:rature control of graphite. ' furnaces whilc drying;aslting and atum¢ing a minplc is . essential for rcliabie,.mproducibk results. Because of'. this fael,anewapproach fohaccurately controlling thee lemperaturee program ~of the CRA has been developed., ANALYTICAL BIOCHEMISTRY January 1976 Vol. 70, no. 1, p. 181 . Automated Determination of Proteolytio Enzymes and of Amino Nitrogen by Use of Trinitgobenzene- sulfonic Acid G A. ADAMS, T. C. Ro.asERTS, AND K..C• BUTLER.. .. Nasioeat £oed Reswrch 7mHrerr, Covncff f ScienriFr mtd sMuniol Rerre¢AL t.O.. Bua .I93:. Prernnn. pN11, SuurA Afn'ru .. , Rer<ived Febnrary 3.. 1975; accepted'Suly 161 1973 ' Pmtanlytk enzyme..,re asrayed using N,N•dimethyl cascia as'.a suMtnte• The enrymes am dctcrmincd in a komoseneous.ysrem, byy meamrine free amino grooq released. Pmlrulyuc aeti.ilpn.eapresxd in aylcim e9uivakms. Amino nilruacn it iSSayN usina an acCClsaakd reaction Mitn 2-J,a-NnilrP lenrenesul6nie'acid under alka/me cundilmnc. Thehnal reactwn prosucr is a aulfae adduet or she Inninophenylmed amine Weupend itsabsurbance al a9 nm k emasured. Tlhee pmcedure can a1G, le u.edfar tltsc direct drlerminatton cf.solulie amino eitmgrn in the range of 25-]30 amokumh - ,.. •.. O ., 0 40
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; ABSTRAChS ASSTRACTS'. ' 1r, '84r.575g2e Flaa•oring'agent. Wrnter. blax; Gautschi Fritz; . . Flament Ivon; Stnlq btax; Guldman I vi 51 Fi , r ng Q rmenich et .,.. f Cie:)'U:S: 3,917,87t ICL 426:-5.76,.A'~LY, 04 Nov1975•. AppL {.452.,342,. 30 Apr 1965; 44 pp. Ba•nzofuran-2-afdeh5'de(1) 1.L a.R!LR•.. n. R•Ye.si.R . . r-. [126.5-16-1], 2-acetv(benzu/uran (III [1646- ~•~ . . 2fi-0], tind 7 mr= rhyfbrnzoJuran-2 o(di ([IF! [57N97-70-8] at 5 X'Ill s 5 X t0= g/1. are flavor agenl.randl llavar IrXdifiers for coffee artd :' food. Fur example, I at 10=gJf. gave ai tnnkalxan liketl:nur ~. W aewgar wiln.•.11 at 4 X'.10 a g/I! imparted a hitter-almnnd, lluwer ~ mRe to arffee,.. and Ill at 15'X 10-1 g/L gavee a bitter, rarthy . tasle: W cuffee., . . . l ot..: i: (Y: . 6 I t~f:. C!1 r 1 } . -^86:42253z Flavoring agent.~ Winter, Max; Gautschi, Faitz; Flament, lvon: Stoll. Max: Goldman, Irving M. (Firmenich et ,i... Cie.) U.S. 3,917,872(CL 426-537: A23L), 01 Nov 1975, AppL 452,342, 30 Apr L9E5; 2Tpp, . Pyrazine trompds of the generd N (CRr)et(0)R -formuk 1, where RIieH.or Me and.n is oor 1, may.be.used in - . small amts. W.improve the flavor of coffee. Preferred for this purpose ere 2-/ormylp,vrazine. [575g-66-51, 2-acetylpyrazine . [22047-25:-2],and:L'ecetany/pyrazine [!6784-62-91. ._ " .. 84:...4;_438y Taste-madifp•ingcompositian. Ilhn•try. Itohert. J.p Fennell, tohn. H. (Mirlin tnqt) U.S. 7,9'SU,NfS (V1. 421~-175 A61K), liff Nov' 191 Attpl, r!i!>.41. 15 Apr 1970: 8 pp, Division of U.S. t•8'4. )S). A'A laae mndifrinF dry. Imwd. onnc: is prepd, frnm. Synsnpah,m dufrifinam.berrit•.s and furmulated into chewahle talileta. F'in.exmnplc, rifk llerrues are eleaned• de itted. wa+hnd in F.tOH Ht47 4:);11• and the meat olurriedandpspray:-d:ied to give a(traderwith. 1-3% HA, 40% protein• and "-5:h car)mhvdratew•hich is stnhlP for 211 year and may be formulaledinto.cheuable tablets. . 84:49721m Clary'eaP.ePralnction i'n,the southeastern Uoited States. f•effin;:well, John C.; Stallinea, John W.t Seller. Franklin. 0.; Lloyd. Robert A.: KmN. ~ ~ n Tnt. CnnAr. Ill. J. Hey•nos ToIS: Co.,. Wmrtun Selem, ' &aent. Oila, II'up.l. 6th 1974. 3. ll pP. (Kug). Allured PuWi Cotp.: Oak i'ark, 11k Cumpda• found furthe: Ist nmcin clary. sage.include trans-6-terp ineof. [7299-41-4] terprnen-4-ot [562-74-0], n-terpinene 1.99-b6-5 , d-gurjunenc [173M14-.5:5-31 and yi,caeyophy!lenefpuude ID. ,I1t39 79-6]l The cultrvntion of elnry sage and, nnrz prod~n. of the.uil for perfumes, and fluvms is diuussed~• - 84i :12255b Flavor coinpositions basedion 25.5-trimethythe= ,. - pta-2;6'-dicnallaad its utotals. Uietrich, Paull. •fhomax„Alinrv F: ClintonWillinm I': l'arlimenL'fhamns H... lCeneral Foods ' . Corp.F U S 3.922.310 (('.I. 2fA fA1H; Cu7CL 2.5' Nov t975. . App1.297•103, 1'l'Oct19r1.4'pp:.2,55-.Trimerhyfhepta Yb~-diennt .- (IY [52912-16-01' or its aceta'a may be used In.n small amta. to import a woody notcW.col'fee -flavored GxRls. I'.was prepd:, in an . example by heating 76 ml 0.5M' 2.5.5-trimethylhepta-2,ti-diene in RtOH W.::rl)° and then adiling 45 ml f1.2nSf Set}i in F:IOFI rwer ,`. a Imriud uf 15 min in an N.uttn. ''he.mrsL wasn.drd..fihrnd, " addilddII1 b n ennc.. to ye I and its QIIIIesp,mnlF Jc. was .elx..y "disln. Itoast coffee ext., conig. IS :r//'6 ctlffee'sole mdlds, Was itht I Widtldfe Ilt treated w sufficien.gve a wuy, nauru aenv,rr.a' ~ ~.1.15% . coffee solids in~, aq. w,ln. Thiw~wr..~fnsze or pray~drie to d ., give acoffee prepn. with enhanced wrxdy Oavor:, . b;.'rn,: (. ,.. . .- 84:.438t8iSpiran derivatives. Renold Walter Skorianetz , , , Werner; Sehulte-Elte; Karl Hi; Ohlbff. Guenther (Firmenich S. A.) Ger..Offen: 2,504,614 (Cl. C07D,.A61K), 14 Aug1975, i S A LL 88 7 w ss pp 3 / 4 04Feb1974;45pp Thtitl(1) ,..eesplran. ~ • .,, ~ . ... .~ . . .. . . :): .. .. nNCNrCNM.OM I Yi - . It ai Mi 111 ~ d inefdb use prumes an flavoring mmpns:,: w•asotained aa 4 L somembyf 11idf1II (X bd)d dehydration o,, oxnt o =ou an •~ LiAIH4 redn: of. Ill', (X =~ 0). Ct-.4 acidi esterss of II were also ' ~.. nr.nd.. "... ., . - 84: 42157w. Evaluation of. the quality of cinnamon by gaf chromatographic separation of the..essentiaLoilk. Zuercher, . K.; " Hudurn; H.; 5trark. Ch: ('Lentrallab.•, Qrop ScSweizt Basel,Swita.L Mitt. Gch. 1'cbrn.vnu)trlunters. Hsq.. 1974', 65(4), 4411-52~ (1%erL. The en+enti:d mla were .epd. in a special _a'rp; from different cinnamnn u/mplos by.teamdistn. and then .. ehrnmutng. Cnmparing.,thnir rcte.ntibn times with thrne of pure . subatances and ul'a miulet mfxt. Ix•rmitird the.e identilicakibn of ...manyy peaks. So nalled nature identical• synth. a•iummmon s arumnswere testrd in Ilike manner, whn.e ehrnnmatogramx .. dmtninrd fewrr'oeaksand duto-werv h.rcumplicated Ih:ur the .. esaentiul uilsiauSnrd l'runt nutur:d ciituarnmt.. Nunignif:irant arnnectinn wasfUulnl In'twePn.. gas l•hra111at,M. reRrd(R, nf the stenmn distd. r+emnli:d. uilsnnd the results ot' smell or taste evalualinn nf rinnnman. . F: E. Gansel 84: 4n-239z Chewing.gum and other ornllvusablev prdlucts eontalnmga flavar composition. htnrmn; Umn Hoero: Frank IL (IuternatLonnl FlAvors ind Fraprantr.,,inc.)lf ti' t 926,X99 (C1. 426-3 .A°-3(;1.). 18 Nnv. 1975, yPp1 5.14•94.,• 15 Oct 1974i 30 pp.. Flavoring mnterials are prepd for.tuein chewing~ um, chewing tobacco, ehewable tatdetx, or toot.hpa:as. "1'heae materials may bee mmcon(ined' or phva. enlrnppedin varims edible matrixes and releasedslnwh• dlurtna.ehcwinp,. For example, aaherrv tlavnrinym agent oontainsm ru;:,mrd f97-53-0~] 1.75, rinnamaldehydr [ III4-55-'1] 4.5t1• ani.qci,arrtn/r.[1:1:11-)L't-5] 6.25, anisnhlcli,dr [t'13-I1-5]9.2i,.Et ennnlhnte [IU6=3U- ]9 12:5, benzy! acetate (140 11 41 IS i. aanJfin [t•I T7 5] 25.0, EtMtPh glvcidate [7, 87 8] 25', Rthutyrale 11h ,4 4197?.5;. am,vl b'utyratr - [540-II(-1)i -d), tblunldrlrcdr f'13.N~7R a]~ 1251 •benzaldehvde [II60-52-7] 558,.and F.tOIi e10, p,rl.c,bv wu. wasuseed either directly or ph)x entrapped in an edible gel to.provideelow-release flavor: . _ .
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:;,, , 84: 42240t Low calorie sweetening eomposition. Glicksman,. , Martint SWankier,. Bartley N. (Generat. Foods Corp.) U.S. ~ -3.922„169 (CL 426-548: A23L1, 25 Nov197& AppL 55,561,16 ,'dul 1970; 3 pp. Continuation-in-partt of U.S. 3,761,288.. :,A readily sol.. lowcalorie sugar substitute is prepd. bydrying a- solaa of an edtbleorge acid and aa sweet-tasting dtpeptide. Thus, 3 g citric acid. [77-92-9], and 1'g aspartniphenylalaninr. ,..[13433-09-5]iwere dissolved in 50 ml waterand allowed to dry -at ambient conditions.for 2 days. The.dhvmaterial wascrushed, and a 0.5 gsampleg was added to 2(10 mlxater at 40°F,.where it . dissolved in 55 see:. Astmilar solh. of dipeptide and citric acid was freeze dried to.yield a hygr~oscn ic prnvder.which dissolved in water in aa matter of second.v. 1'hedissoh•ed material had a sweet,:slightlyaciditaste.. . 84:39363e. Effects of' densturants on the sweet-tasting F rutein monellin. Morris, James A.7 Cagan, Robert Hi Monell Chem. Senses Cenl, Univ: Pennsvlvania; Philadelphia,. ~Pa). Proc. Soc. Ezp: BiaL Aded. 1975, 150(2); 265-70 (Eng): _, Monellia treated with6/Yf guanidine-HCI [50-01-1] or B:lf'urea .[57,13-6] at acid'. pH retained all'~ its sweetness after removal of ~the denaturation agent.by dialysis,, but urea.treatment,at neutral ' pHd iibl lft ThH causesomerreverseoss o sweeness.e• pH maintained duringg dialysiss did not affect sweetness: Pptn,. of monellin was least under acid conditions, and pptd, protein wasnodonger sweet. Gel filtration chromatog. shuwed.anaggregated protein in which the single sulfhydryl group had apparently been oxidized. The tertiary structuree seemsto: be important in thee ability of monellin to elicit a sweet sensationj 57434h @uantitative: determination of saccharin in . food products by ultraviolet ipectrophotometry, Hussein, Mamoun M.; Jacin, Harry;. Rodriguez; FrancisB.. (Life Savers, Food Chem. 197,6, 24(ih Agrie d YJ N . , - Ine:, Port CMester, . . 36r40~ .(Eng): In the detn..of saccharin [81-07-2 m chewinggom and other food products, saccharin isisolated'byentg:.theactdtGedisample saln, with CHCIa. The residue, after evaporation. of the CHCIs:is dissolved in 136Na:COs and ahsurbance isdetd_d atY35 and 244 nm; the.latterwavelength absorhance,is to eorrect. for any possibleinterference: Recoveries were 83-113%.. Analyses of'comf products of various~brands gave 90-105% of.. . label daim.. 84: 55278m InsecGieidni activity of sbme synthetic pyrethroids agains0 mosquitoes and flies. Harlbw, 4'; Hadaway, A. B. (l-enL Oversens'.1'eat' Rus.,. le+ndun; Eng1J. PANS. 1975. . 21(:1), •CCL8 1'F:ug):. The insecticidal thuentev of trtrametfuirt (1) .(7698-12-01 and resmethrin (11) `10453-%6.8]iand their derivn. was studied in tholah,,, on Annphrfes stephensi,. Glussina aaRLFnr,.and StbnWl%': 2afCitrnn.Y, Cis lumlera MerP, mnrc to+icthnn trnns mnmers: The replacementuf side-charn Me •n'ups in 'theactd moietyby halogens also iner.used tuzin v.. AGeranons of the ale, component gave variablee results 'Fests_ were eunductedon persivtenceat the site of application usm, A. afephensi, I[,, which isphnli,dl5radeds was nntt persistent; however,.substitutionwith 3-phem+xyLun.ryl„as in phrnnlhnn [2g002-80-2[ imjunved light stnbility:. but not tothe extent reqpired for field spraying: Replacemen4.ofthelight-senxitive ehrysanlhemic.acid component of,phennthrin byy the -: "-dichlurnvinyl anolog gave a persistemt ester which was lung-lastutgand had greatly increased tuxicitv_. ,VoLr 6, No. 6, MARCH 19, 1976 . 84: 54937p Glycagenn content, glveolytle and respiratory activity, and A'fP. ADP, andi A31Pconocntrations im rat. brain followingtrichlorphon (Diptcrcx) intozication: Sikorska6 " .M.; Biczowa, B.; Bicz, 1W; Skunicczna, M. (Inst. Biupharm.,,. Med: Acad.,. K'arsaw, Pul.). NeevopatnL Puf. 1975,. 13(3-41',.. ' 447-54 (Eng).The major glucose metabaliec pathways of brain cerebral hemisphere were studied Gdlnwine short-term and chronicintoxication!with trichloorphun (1/'[5'.-68-6],a phosphoorg. insecticide. Three groups of rats were studied: (1) those administered'a single do.sage.of 110. ur 50% LD:v1: 1?): animaLss . administeredi the same d6sage, but for a perio& of 14' daysF (3) ' animalss administered a. 2%. LD;.. of I for 90 days. Cerebral - glycogen [9005-79-2]', significantly incrrased in thebrainr of goups !ad thi ic ptioal th rn 2;snrease wasrotwrnl toe dosage ; given. At the highest'~ dosage (507 LDr.).. the increases - amountedl to 32 and 54%. resp, Group 33 rats showed a 14% increasein glycogen. Glyculylic activity was~ nnlv slightly increased and ADf" [58=64-0] and A.SYI' QGI' 198] h•velswere~,.unchanged under all exptl. conditions; huwever A3l [:.0-6a-5]I increased. A dosage of509n. LUw wasnecec.arv for a sli):htt increase in ATP in.then graupI cxpts. Grnup' ammalashuxed .incsea.ves.in ATP levels at 111 and 1 i.o 1!.Iku and ),rnup.:fanim,ds. '.. showed increasedi . A'I'1' Irrels fulli.wing chronic. hw Ik,w Ircrl . intoxication with I.. I isprubahlymeudcdiztd ludi(hlurww mul' . it iss probably thislatter cumpd. whichi is respunsHdi• Ge ahe -toxireffcctsobsd ... .. . .... .. . . .. . .. '- 84: 55336d Long-lasting insecticido activity of' pyrethroid 'fumigants. Takei, Yasuharu (Fumakilla, Ltd.) ,Papan.Kokai 75,142,728 (CL AOllN), 17 Nov 1975, Appl. 74 51,237, 10 May 1974; 6 pp. . Surface-active agents. added to pyrethroid tr Vw wv fara~arr. I fumigants prolonged theinsecticidal activity.. Thus.,a pulp pLhte .3,5 x 2.2 X 0.27 cm). was impregnated with allefhrin (1) It584-79-2] 70.and dioctyt sulfosuccitmta. [2373-23-1] 35 mg in exane. When.theplatewas heated at 165-701, the amtss of the insecticidee released into: the air fur 0-3,. 3-6, and 6-9. E•tr were 40.0, 25.1, andi 15.9%,, zesp._ 84:55031a. Activities ofsome esterases of'thr cntt brain after intoxication bv the orxanoplrosphorus insecticides diehlbrvosand triehlorphon. Pachenka. ,I Sulim+i. A:; Ziolkuwcka G: Ilnst Htuphnrm., A0.d Arnd; \Warsaw,. Pull. Nrurnpntnl. I4d, 1975, I¢(t-4). t, r('' (Enc)A single oral administration eddichhneu (1)[6+ 7T7] at'u0% LD,atu rats decreased the brain levels nfof] phn.plmtant' (90111-78'-9) aeidPhu.phnrasr ('J061-77-H].and arrWrhtdm<uerrn.+r I9tl1111-81-Ij by 45. ib and 58%. resp, 'fhesamc trratment wtthh tridifnrphan (fll (S".6tl-6]' decreased the. acetyichulinesterave, activity hy 74%. but had no effect om the 3'phnsphatn ec: Repented admini.stratinn of Iat 50% LDs, fur 14 days, producedla 25%% decrease of-acid phnphatase activlty, a W.^% decreaxee of acetylcholinesterase activity, but hndno effect an alk. phosplmtuse activity. Similarly, repeated treatment with 111 produced a 70% decrease in, acetylcholmesterase activity and a 10% . increase in alk. phosphatase.activity.whereas the acid phosphatase activity rematnedunchanped. Thus. I or 11 intoxication nut only inhibited the acetvlcholinesterase activity, but also affected the activity of'.phosphetasea 00009168
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f PESTICIDES ABSTRACTS .• Nou. 1975, Vol. 8, no. 11 ~ .TS2757. Hinderer. R. K. (llair. Maryland. College ~ Park-MD6.AmmpnHe<.9udynfenymeatllvHiecand. ~1-'tylnclfrome P-45B'levek nflvarious lissues of the nl and ' Japanese qua0 nilh respect to Iheir melubolism~arueveraf . .. ~. peatkidts. biar. Aharr. fnl'. 7N?I: SbSB: 1975~~. . .. -~. F-nzYmeactivilicsandcytoehromeP-d[OleveliwErr .- kund'.to vary betw_een tiswe fntaiuns and' between ani-- ' tBehlorhenzonitrik)wereappliedannuallyfor5.yearstnan apple.orchsrd. The.nurltlier of brambles rRUbm sp:7 and'- ' Virgininclemalis(Ct•marisrirglnionu.L.)pWnlsjncreased ;. with tcrhacil usage<.Bramble pspuWliuns increased with ~ Ihe high rale of dichlbbenil and goldenrod tSrJidegn sp.j, '= increased at the lownte. Themajor vegetation on:plots, . receiving amitrole (3-amino-r•Hianslcy, warant ahered I ; '.' Btsm Itral of a mowed check. However. amilrole reduced . gro!sthof shallow planled.lrees:.Rostemergenn applica- tions of paraquat (I.I'-dimeshylj.0~-hipyndinium ion) ' four limes during each growing seasnn resulted.im murre' ' bare sml than was in the mowedchecksanhexnd of thi' ' fifth growing seuson: Yieldsof appla:weroAlghcr io-.the•. - aimazinc.tcrbacil.anddichlobeniNlrealedplutsthaninihc. ' moued.checks. Simazine.and Iurbac'd residues did noll - • accumulatr:inlhe.upper60cmofmildtmngthesmdy':asBghtaecumulatinnofdiehlnbenilappearedtonecurinlhe '..surfa.-e0tu15-cm.(Authurabvtrsetby, permission) - METHOD FOR OBTAINING SPECTRA FROM SUB-MILLIGRAM.QUANTITIESI' INICONfPINUOUS WAVE NUCLEAR MAGNETIC RESONANCE SPECTROMETRY ANALYTICAL CHEMISTRY_ . : March 1976, Vol. 48, no. 3, p. 629 Johnnie L. Stewart & William L. Clapp Mebhods.for tFa use of microcells in nuclear magnetic eeaonanceapeetrometryINMR1 have been reported pre- y vioualy byVarian AssoeintesApplications Laharatory, (dl. These metiwd.-& reyuire.transfer oCtlse sample from a cul- feclinn device to a mierocell. Bince the major objertive:of micro N6IIt.analyreis is to obtain mesimom'signl-to-noise from a given amount of aamp&. Iheprublems of sample transfer, cleanirry;, Blling, and positioning, of micrncells must Ire nvercn.rve if signilicant imprmxmenu ere to lae re- alisedi This aid describn tfie?abricalinn and'use of a micrrwell r thatoverromesahese probkms,.By heat eeaiing a gas chrn- ' mawgrnphie collectinn tubu:and tss.ing a propedy sleeved turbine, micro samples may he run in the.e cullecliumtuhn with sn inneasein sigsul-lu-nuluotbs and'repruducibili- ty. VOL. 6, r1o, 6, MARCH 19, 1976 t ANALYTZCAL,BIOCHEMISTRY January 1976 ` , Vol. 70,, no. 1, p. 208 A.Simple Procedure for the Assay of'Low Levels of Aryl .. Hydrocarbon Hydroxylase Activity bySelective: '' . Adsorption on Polyethylene, . . .. . . . .• ROBERT NILSSON, ELISABETH PETERSON, AND G'.USTANDALLNER . _ Deparra.reu4 9brlvmlmvundRudinbinA,RT. U:ii.vr.ir.o/Srurfbvlm: . . nndDeparrmrnr IPardslnRparSrhboubrrtHMPUaI, . Karonnskn Inanruhr.5raihrdnr. S4edrn - - ' Received April ;9; 1975; attrpted )uly 16, 1975 - 4 . The,uae of solid pdyer5ylene to xlcctivelY adsarb Rpophiiie suMUnps from •aqueuussolutionscon!aiNngtheirmirepolarmeubuliusprovidesrhebasisfma verysimple.and somitivrasaYof arYl'hydnrnbun hydrosylau aniviiy in . ' 1!iolnricalmaterial:AfterincubaJonafvarww.ati..usormimsnnwlprcpanriam ..(n prcaenrrof Iobdrd naphrhalenr and an NAD1'H}<nerimg.syaem:.lhe unchanardhydrorarbon is removed quanumJvelv by +haking the mn!ure in polvethylcne mbes:aod ther metabotlres arewb!eq9endynaawud by v:rnrlllroan , roun!ing. Thls method care be eslrnded. lu awY tNeM biuWplai uaidaiiw of wbuances Ske 6enrpyrcneif the hyldroayBied produab arc fitu cosjugaad with glucumnic acid. . .r. , . . HIGH-PRECISION ANALYSES BY. ATOMIC'ABSORPTIONI AMERICAN LABORATORY March 1976, Vol. 8, no'. 3 p. 49 F. J. Fernandez & J. D. Kerber M ANY USfRSof alumic,absorption equipment are oflen raquiredito pcrlunnn high-precision analyses on bolh major and'd minor conslito- . ' ents in Ibe samc samplc. The objcclive of this paper is ' tofocuson instrument considerations.for optimizing . peecision, w'illu particular ensphasis un appliraliuns . invohing.dctenninatinns at luebicomartration Ievcls. Areas of invesligalion inr:(rdc effect of si,qnal inlegru. Bon, peecision vs absorbancc level. olslinmm working f ouges, and cafibration teclwiques utilieing.mnlNple standards. Tm sludy. both precision and arruncy. variousNBS slandard refcrencc ml<rials were anom lyaed fur a variety of asajonelcncnls.
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__ .:,&iS5110k Assnciationofsalmoncllamutantswi'thgermfiree Sitifidbl to(retcct rats.especc.mn carcinogens as mutagens. Imrry A.;'Q:arter, John H.; Suderlwrg• Frances Rl; Wheeler , r•~-Coldman, ]'eter (Hsrs•ard Med Sch.. 1letlt IsraelHospr, `' e•"Fkulon, Ma.c.).Prae. NntL Arad Sri. el; S:.A. 1975i •r2llll). -4607-11 (h:n1r•). An ncsuen. of the hixtidine auxntro'rhof S. -fyplumttrium Istrnin.•I..A151pqwithin lhegostrnlnlestinal, trnct.of lUlitid dri "tlttetwi.ae germl}re.Jpra6ve-uwey. rnts was ntanunt,ung ' peritds of observation laynug as'.longas 7, months. The bacteria ¢_i. l II ~fn-' V v ~ ~NOr, were found at~levels >l0i/gin the forestumachand at.levels >l0s/g in the lower bowel and intAe leces. Onlyn approx. 104 '_bacteria/g.were.found in the posterior stomach and in the..upper ;'.smalh intestine. The, assoca. of Salmonella mutants was : maintained when the bacterial assocn. wass increased by the '' addn..of other bacteria eharacteristic.of the gastrointestinal flora. ' Carcinogenic amines,.which caused straim'PA1538to retrrt to 'histidine' independence in Ames' invitro assays,increased the f ih fh fd S _ anm o revertantam teeces wene,toafntonella-assucd. eats: . In conarast, the na of rerertuntsirn the feces did not increase when the rats were fed structurally relaledrompdsd w•hich.are not mutagenic to the bacteria in vitro and forwiiich . no evidence of' carcihogenicityy exists. Sacrifice of rats after feeding the carcinogen 1-nitro/luorene (I), [607-57-8] indicated ~,. that the no. of'revertantsis increased in the cecumand colon as well as in, the feces.. TAee apparenu proximityof the bacterial ., -mut•rgenia.response-toc thelocaGon of the tumor responsee in the srolonsuegestedthatthe.ratassocd.xithtinehistidineausotroph may provide a useful modelforr further.r investigation of the possible assocn. between baeterial mutagenesisaud carcinogenesis within the: gastrointestinal tract Lt addnn with this model it may be possible toevaluateselectikelyo the effectsofs various constituents of the flora on~the activation of compds. provoking the revertant response. ... .. r I . - . 84: 39560s Carcinogenic N-NitrosoCompounds-Aclion• Synthesis;Determination: (Proceedings:of tlte IsIS>'mposium, 25 Octobcr. 19731. (Kantserogennye N-Niiroto.cuedineniya-Deistvie. Sintez, 0predelenie. [Naterialyt-go Simpoziuma 25 Oktyabrya 1973[): lioo-na, G.; Editor. (Inst. Eksp. Klin. Med.,. \4in. 2dravookhr, ~•at. SSR: Tallin,. Est.. SS12). 1973. 96pp: rubie 0.45. . . , . . . -84:'63958j T•.ffect.of benzo(a)p3'rcne induction of liver and lung metnbolism in ad]uvaut'-diseased rats: Carlson,.Richard P•; Ciaccio, Edward 1. (Dep,.1'hannacol„ Hahnemann Med. Coll. Ho.cp., Philadelphia. Pa.). Riockem. Pharmacol. 1975;. 24(20), 1893-5(Eng), . Rat liver arylhydrocarbon. hydrozvlase. (1) [9037-52-91 activity, a specific microsornal drue-metabu[izingsystem (MDhIS) enzyme, was elevated 4'-foldwithin 2ldays off benzo(o(Pyrt•ne(11). 650-32-8] (25mg/kgJ5 i.p.). administration, but fell to control levelss by 9daynfter fl administration. Incontrast, lung I activityy was elevated 9-fol& 2 days after II treatment and remained elevated7or >14 day lf treatment alsoprotectedlzata against the impairment ofhtDMS.by adjuvant disease in both tissues, withdhe protective eff'eet Aein greater in lung. The development of paw edcma was unaffecte by 11 . 11, therefore, did not act as an inducer fnr detuxification mechanisms of ad'uvanq even thuughit prevented'' the deterioration of apecific exOrahepalic MD81S enzymes.. VoLr 6, iVor 6, MARCH 19, 1976 86:4938Jiffuman. health effects ofair pollutants. 111. Two-hour exposure to ozonealone and in combination w•ith olherpollutant gnscx. HackneyrJatk D.; Linn, William S.; LaW, David Karuza. Sarunas K.; Greenberg. Hnw•ard- .. $uckley, Ranrmt D.; Pederscn, E: Eugene (Knviium Health Iab., Rancho. bros Amigos Hasp.• Downcy: Calif.). Arch. .~ Enuiron. Health. 1,975, 30(8), 385 90 (P:ng) }idulp male volunteers were exposed to:O3. [10028 15-6] a00.^ r.0.37„or 0+50 :. ppni, and to O.r in combinationwith NOa[1010'S 3A-0) and CO .`670-08-0], withsecondaryh stresses of heat, intennittent.light . t, exercise; anch repeated.exposure.. Fewimportant physiol. changes o-.::.•and only mild symptoms were found with 0.25 ppm O). with t1:95 ;.ppm 03 plus 0.30 ppm. NOz, or when 30 ppm. CO was added to .. the latter mixt. With.0.37 ppm~Or, more symptoms.were present ' and some subiecta devdloocd decreased pulmonarv function. At >~0.50 ppm Os, most subjects had symptoms andabout half showed substantial pulmonary function decrement. In reactive .;' eubjects exposed oa 2 successive days,, changes usuallywere :.; greaterthe 2ndld day, indicating that effects o8 successive ML Dilli ,., exposures were cumulative. .,. I /,;....,.rtg. / ~ .... - . ... .. .. • 84:305I6g 1[olc of some atmospheric pollutantsin the genesis o6lungtumors caused by a chemical carci,nogen. - SkvortsnvaN. N.; Osintseva, V. P.; Pushkina, N: N.; Yysochina1. V: (lnsl, Obshch. Kommunal'n: Grgim S in .„ ys a Sr Moscow, USSR). 4'upr ltiopl..Gc:ryaz.OkruafioyushrheiCheF. •edy KahLrerngennymt Ve.hehe,YCami 1977.. 61-4 /Russ). I Inhalation of.0.4 mg/ms phenof [109-95-?1 stimulafed carcinugenesisprduced in rals by inlratrarheali instillaGuns of 5 mg drses of Senzno [a~PYrene (11 I50-32-8], esp. when 3months of I instillatoonspreceded a a mnntB phenul inlialuliun. Slimulntun of.glyrnlyxisby p>hennl arld I w+u~ esp. pranounced in the offspriua. ot unimaLv expnsed tu phenul mfd.1.. 84: 39537q. Comparison~of the mutagenic:effcct of carcinogens and their noncarcinogenic analogs. Avertsev, Sl A. (US5R). ` iSb. Robot). fn-T Tsttol..A+Y SSSR. 1974. (16), 108-9 (Russ). FromReJ Zh., i?iof. Khim.:1975,.Abstr. No. 18FIfi79: Title only translatedi . :.>.s. •w:-".''.... t. . 84: 54832a Determination ofcnvironmental carcinugens in cancer epidentiolog3' studies. Riigovski, P. (Lynns, Ft.). Eksp. Kl+n: Onl:oi. 1975, 2, 5-I6 (Russ). A review with 49 refs. . , . , . 84: 39515f Modifyint; effect.uG water-soluble shale phenute on cancinogenesis.. Mirme• H. (Inst Eksp. Klin: Med.., . Tallinn, USSRh Vopr. !ro/il..7,a„ryaz. Okruzhayu.nccheiClief: SredyKantserngonntmf Veshchesthami 1972, I6-18 (Russ). Edited by Shabad, L M•. 'Valgus': Tallinn,. USSR. Total' phenolk fromwaste waters of a sllale processing plant; applied to mouseskrn e0 daya after applicatinmof.a subcarcinogenicdose of benzo(a) yrenelff (50~32-8]I(0.;16mg/Ynuuse)•nuseddevelnpment ofmainP malignant neoplasms in 48.6% of the mice. Oranol. (5-methyIresorcinoDlll) [50J-15-4] isolated from the phenuls was moderatelv cocarcinogenic. 000091 M 8 ' . . Etlned:byShabad•L.M. 'Val¢us': Tallinn.USSR_ C..nr;,.,,,.,,.
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ABSTRAC TS ABSTRACTS ~' "'84i 49740q Perfume compositions and pcr4rmedartiel'es `~ containing dialkyll and alkyleac acelalb of 2- and 3-phenyl ' pc ntenals• Schreiber, 4Villiam~ L: Vock. Monfred; Hall, John - B.; Shuster,.Edward J.; Quinn; Afton D. (International Flavors '"and'.Fragrances) U:S 3;92.".,237 (CL252-522;AG(J;CIiB),. 25- Nov1975., Appl. 276,922, 01.Aug 1972; 14 pp. Perfumearoma '~augmenting cornpns: containi acemis of 2- or 3-phenvi entenal. Thus 3-phenyl-4-pentennl [939-2[-91is areated withh1e0H xr~' and.a small amt• of AcCI catalyst to give 3-phenyl-4-pentenai ,,~~... dimethyh acetal (1) [51758-21-5]. A perfume compn, was •s •. . prepd. contg. a no. of perfirme ineredients, Land 3~-phenyl-?-pentenel •r v~.drmethyHocetal (tl), [51758-22-G]:. [imports, a green,.balsamic, <- einnamon-like. topnote and 111 imports a green, rosy character to . r.r 1, 1 . the~topnote of lhe~fragrance. .., .... r.!,;; ...1:.,,t '.84: 421g7c Gas-liquid: chror~rratograph~ic dctcrmir•ation of • -.: aaccharinin foods.as an N-methyF derivative. Nagai, Isamu; -':~ Oka. Hideo; Tasaka; Miwako; Oka,.Arata(YamagpchiTrefect. I Res. Inst. Health, Yamaguchil Japan). 5i.rci KngaRu 1975, 2616 (l): Ahdatit - 21(5),-.apannew metvm method for gas n ~ . chrom:ntrg: (6C) dcln. of soc•rJmrin[81- in fntals aas 074] established. Saccharin u•as extd. frnm sample with KtAcOand converted'to N-Methylsnccharin by reacting with (Meh.504 in - atr.tnncat rnnm temp shaking fnr 10; min. Afthr decnmpn. of- (MehSOt witH5U7c NaO}%L N-Methyisaccharia.was.detd..by'GC with a flameionizntiom detector. 1'hereaction prmiuvtt was mnfrrmed hymassmtd irrspectra. The N-M'ethylsaccharin pield was 90 G:-'Jfi.GEe and therewveryof saccharin added to foods was 77.3-94.39d. N. Tanahashi -' f4r,42035c Natural and synthetic sweetners.' Alternatives . too sucrose. blar(eusson, liaj. (F'orskningslah.. Svenska Sockerfabr. Ali• Arlov, Swed.). Kem: Tid.Hr. 1975, SS(11). 8U•L, 65(Swed). A review•.with nn.refso of the sweet tastemnd .• lll B PO tvnBu•lic nnt n:a.urn zoarele•nrn. ...ryL I4r 42087y Gas chromatographm.determmatton ot saccharin after methylationn with~ diazomethane. Unterkalt, Bernard ' (Fachbereich Pharm. Lebensmittelchem., Univ. Marhurg/Lahn, 'Marburg, Ger.):. &Lebensm.-Unters. Forsrh• .1975, 159(3), 161-4 (Ger). Saccharin [81-07-2] u•asdetds by gas chromatog. --aftermethylatmn with diazomethane [33-1-88-3]. The.reaction . products included N-mcthrlsacdrarin [(5I4g 99-4], and the O-methyl ether (~1871'9-14-G as well as methozymrbonyi@enzen= esuffonamrde.[57G83-71-3]'~yringfissiom , -. . . • , ' . ... :. i ,.,.~.. . . ... . i 8t:5978(ly Sesquittrpene dcrinrtr'res.' Schulle-Elte,. Karl H.r Jaycux Michcl: Ohkdl, Cuonther (Firmcnoch~S. A.). Cer. Offnn. ?,J.1a021 ICl (•tbC,A•d[3L,..~G1K). l1Sep.1975, Sedss' .,Appl. 319G/7•1, 07 htar 1974; 17 pp. The formates.Iand 1 1 (9.7 ncA C19 ID Me K) were ohtained hy treating 10 g 9S% rnryr,johyllenew•itlilltgIl(•11_i'.(, fland 11 hadia w.u,rtv,alnr.useful,in prrfume ormlPr.` 84:'.574JSk Sugar determination by the anthrone method. Cerning-fleroard. Jutta (;tn. Hnxturn. Phys.-CHim. Cereades. Inst. Nall Rech: Agron Massy. Fr):.. Cereal (•hrm. 1975. 52(6), 8i7 bU (Kng). Utiir(, freczu drnd potatues and corn, the - sum.of the sugars detrl. individnally by enzymic methuds (glucose, sucrrx:e,.and rattiuose) audd mthranee prnceduree at :dt" ,(fruetose): using the same sugars a..aldc.,.w:~s in clnse agreement withtbtal sugarscstds by dle anthrune methud and expresvcd in terms of glucose. Using horse bean and horsebean Ilbur and glucose as std., the valuefur total sugars was considerabtyrlower than the sum of the individual sugars. When lutalsugars were directly detd. Hy anthrnnee and e.presxdd in terms of rdfim/sc, the valuafor total sugars was much closer to the sum of the - - ` idiidlldd Ffhfl nvuay.ety su.;ars;.•xamm.m o te reaction o equa quantities of various sugars with anthrone reagent (heating, 12 mrn in a boiling water bath) showed absorbancee values decreased in thee order sucrose > glucose > raffinase>fructose > ' btechyose.,. _ . . . . _.. A,. M..Briant. 84:53G12m Food flavormg 2-ethn:lidenc-3'-alkcnals and iatermediates. Schreiber, \4:rlhamL.; Pittet;Alm10. (InternutinnaC. '~Flavors and Fragrances Inc) U.S. 3,922,309(Cl. 2G(F6011t;.C07C), 251 Nov 1975. AppL, 383,579. 30 Jul 1973; 8 pp:. ,RsCHC14zC3C}[ (R = H or Me)reaeted with !41g or with BuLi„ then with (Rt0)zCHCN (RI = Me or EtP to give R_C1iC}IaCP= CCOCHIORI)2. which mrdenrent the SL'ittigg reaction with MeCkIIPPha; the. Wiltig pruducts: were hydrolcaed and partiallykydmgena[ed tao give slercoismners ol H;Ct.ICH:{;ILCHC(:= CHMe)CHO (1): I(R.= H) ) had a floral, sligMlyrucumber-likefragrance, while 1.(R = Me).greaWy enhance(I anorange Ilavoring.g miat. 84:5758tgComposition ofOragrantf substances with a strawberry scent. Khveca,A..4(u: Litvinaua,l;.1.: Gornnxtaeva, A. A.; 7.ueva, A. V.;. ti++gdnnov, I(. A.; Slullna, Il. F.IAII'-Uninn Scientific-Research Institute (if Srnlhetic.and Natural Perfumesl Clllr, A2;ill. 25 Aug 1975,. APpI.• SSIIt 481637 (CI U ., : .., ' 1,975;843;12'Dec 197:1! From. fJtFrytiyo, L•nbret.,. Prom. 'CJbrazfsy, Tocarn•vc ZnaAr1975, 02(31). 87.. For obtatning'.g a seent close to nalurat striwhr roy and (orr increasing its strength, diixnprnrylncetone (10'91 7(1-5] U. r-SAI, caunnrih [91-G1-5) (05-2:0), dlphenyl oxrdl• [101-87-8] Ill > .1.U), mel7r>1'~alcnraprnate. aeetate l I 0-10); ~ n eth 1c snlicvlntelt(~ 0 r fa),cclhyl pcinnarnate --(3 0-0:5), ethy4 laurate. (20 0~22 O), isoamyl valerocapruate (L3.0-2G.0),isoamy'I.acetate.('4,0-27.5.wt.9a). 84: 5SGIlk. Alkenals end intermediates. Schreiher, 1V,t'llia:n L•; PLLtrt Alan O. (hnrrn, iannl Flhcors.and I rn~,rmuc3Inc.) U S, 3.9'U;7:,; (Cl.. -i,o-. tu..At ('dW). l8 Nov 1975., Appl. 383,579, 3(f .lul 1970; 8' pp.. trrrns;rix-(U, frnns,trmrs•, and cis,ris~2ctF•clide.ne-3hesenal,and2ethyJidene ti metltyl ris= 3-heptennl,*usefvd nr fiacurinp a ge nls.. genls. were prepd. Thus. Et\1trHr was heatedi with. Rtl':Zllih rlher at reliur and the product (wilhout isul:ttiun) Irrated with (Nli•0)cCHCV nnd then and hydrnly>cd:tu gir~r IitC:CCil(11(U\lai.- 111). IU w•as treated with Pb,P:t'HXIc Inbtmud ht- reactuon of Phop`litlir in Cr.llk with BuLI in hexnne)tn give htC:CC,(:CH,h1c)CH(031e)e(icomer mixt.),, which was Mdrohred, and thee resulting aldehyde hydrogenated over Lindlnr rnt:dyst to give 1.. Orange ilavor fummlatinncontg. I avs given. 00009167 290
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8t:40139t Peroxidases from cell suspension culture, Z .Properties of peroxidases fromtobaccoeetl'suspension , Hideaki; Noguchi; Masao(Cent Kes. lcst - Shinshi .culture , . ., •=Japan Tob. and Salt Public Corp., Yokohama. Japan). ".Phytoehemiatry 1975, 14(10).2141-4 (Ehg). An enzyme prepn. -fromsuspensiom-cultured tobacco cells nxidized indoleacetate /I) I in the presence of added mfacwrs• Mnt+and 2,4-lichlorophenol. ' showed 2'. pH optima fdrr thee oxidn: at pH. 4.5 and 5:5. ' Effet•ta of various phenolic compds~. and metal ions on I oxidese The properties of 7 peroxidasefractions ' activity were examd' • 7epd, bycolumnchmmatogy onDF.AE-cellulose.and CM-Sephadex, The peroxidases were differentt in relattve :' trompared were • . . activky toward o-dfanisidine and guaiacol. All the peroxidases - ~ .~ptalvzedI oxidn. in.thepresence of'added cofactora The pH •, •:optimaforguaiacolperoxidn.were.vervsimilaramongtheseven Th diffe d e rent h. were .. Isozymes„ but the optima for' I oxr ... . --- , u.__ ..u ....,,- -•.,,at58 6„t ' tha cationic isozymes showed'opttmapH.4.5. Witfiguafscol t as H'donor. an anionic peroxidase (A-1) and a, cationie -peroxidase (C-4) were very'different in HiOx aoncn. requirements for their' Pefoxtdase A-1 was aotiveat a~wide.range of activity . , 'H_4e concns.. whde' peroxidase C-4 shtnvedl a more restricted "HsOa requirement. Ge1.Gltratian and pdvacrylamide gel studies ~ indicated that the a cationic peroxidases have the same mol. wt . l 1 . ~~ ' ~ 1 f ) ., J~1l. ...... ...ta..-,• ...L'. .. . . .. . _ . .;.r,. . '. N4:.S5262b Effectivnese oftfranulated.insecticides against thee aphids on tobacco. Dunko, Jan (Vysk. Ustav'Pabakoveho Priem., Bab, Czech:). dkrochemta 1975, 15(9); 280-2. (Slu). :-The yield of tobacco treated fnr control uf Myr.apersirae with enulac 20 kg10°r Temik [t16-OG-3[, 40kg L'0%. Solaircz ~f 298-04-4], on 20 kg1070. Furadam 11563-66-2]yha, irtcreased - bv11.8, 10, and 3.6%. resp. Furadin nndlNiran (56-38-2] were ' tfm.mosteffeutivcof 8 inscelieidc.v Irsterl acnittgt tfie,soil pests: . 84:55239z Effect of diphenamide on weed control and , tobacco seedling production in Maryland. Hoyert;J.H: (E~f~ Pub lin Ta a«o' 117123).0140-1L 1975„Al9n'51 2v. n '..Diphenandd [957-51-71 at 2. 4,. 6, and 8 lbs/acre applied preemergence controlledgrassesd and some broadleaf weeds in tobswu.'Ibbaaoaeedlingsurvivalwavgreaterindiphenamid-treated lots~ at all rates than .in. control plots; however,, at 66 and 8 Pba/ane diphenamid' caused stunting and abnormallyy shaped •' kaves.im1i of 3:.)'ears of thee tests. . 84i.40925w Liquid suspcnsion cuYture oP tobacco cclls• Kato, K. . Matsumoto„'1'.: Koiwail.A.; Mizusaki. S.: Nishida,. Noguchi; M.; Tamaki. E_ (Cent. Res. Inst.. Jepan Monop. Corp., Yokohama,Japan). Ferment. TechnoC.Today, Pror. lht. Ferment. Symp., 4th 1972. 689-95 (Fhgij Editedd by T6rui. Gyozo. Sac:. FermentTechnol., Jpn.: Osaka, Japan.. Of the eallusess induced in >40 species of 6icotiona:t that induced trnm. N. tabacum var BY-2 was most proliferative in cell suspension culture without kinetin and myornositnl. Jnn the medium. Cell"Powth was markedly enhanced bw mcreasing the morg, phosphate m,the medium. In cellatuitured' wtth, 2:4-D mcutine, w•asnut detected,. hut aoprectable amts: of ealteoylputresnne. p-coume= roylputrescine; and feruloylputresme were present. The:formation of nicotine in the cultured cells appeared& to be represse& at and after the methylation uff putrescme• In a_0-1. semicontinuous culture ofBY-2 cells the yielda of cells were 120-30 g(drywL)9 pet.day, -- . . . ...- _ ~ , --_. .,..._._. . VOLa 6, H01 6. MARCH J19, .•1.976 '° -84:39587f Protein syntliesis'requirement for the'cytokitiln effect upon tobacco cel!I division... Jouanneau, J. P.. (Lab: Biochim. Fonct. Plant., Cent. Univ. Luminv, Marseille; Fr.). . - Esp. Cell Res.. 1975, 91(U, 184-90: (Eng)• In tobacca cell itihidiiii suspensons,..proen syntess an mtotc actvty were inhibited p-fluorophenylafanine (1) [60-17-3] or5-methyltrvptophan (11) [154-06-3].. After inhibition by [, when the mitotic activity recovered in the presence of'phenylalunine. [63'-91-2] and easeinn hydrolysate, the time tahle' of themitotic phasea was ' permanently'y alted Th ihibitifffeily Ire.enng effects o 11 were ectve o:reversed by tryptophan [73-22-3] addn. to the medium. ,r Therefore fI was selected for' reversible protein synthesis ,itthibition in partially synchronized cell suspensions. When 0: eymkinin was added in a culture where protein synthesis was -.r iahibited by [I,. no mitosis was obsd: afterr the cellss were ~~ transferred to a hormone-free medium and protein synthesis ~ restored by'tryptophan. Cytokinin required protein synthesism .-orderr to restore: mitosis. The' effectt of the protein synthesis .. -' inhibiGon by 11 upon the metab. of N<-benzvlndenme[1214-39-7] , was investigated: the intracellular cuncn. of this cytokinin was -`not altered, whereas the metabolic pool of its derivs.. w•as.quant .. .,, ., . . .. . _,_ . ........., _ 84:5G521x![igh affinity~receptorfor fndoleacetic acid in cultured tobacco pith explants. Oostrom, H.: Van Loopik-= .. Detmers, M. A.;, Libbenga, K. B: /Dep. Plnnt Murphngen:, Rijksuniv. Leiden, Leiden:Neth.)! FEBS Gett. 1975. 59(2), ;,19L1-7(Eng). Studier.with cultured tobacco (white Burley) pith •explants cfearlr indicated the presence of a receptor for :",indoleacetic acidYin the cytosoli Tne.specif;city'of this receptor ', remains too he detd., but since the assocn. const. ~vas high ' : (10B/M) thbidiill bifi .,e.nnga• probablye:veryspecc. 84:40849a Tissue culture of a tobacco'albiho mutant. Sehaeffer G. N'.:' Menser,. H.. A., Jr.. (A12S,.. Beltsville,. hid.l. Ciop Sci. 1975, I5(5), 728-30'(Enc). The'.tissue culture ~rowth• of tobacco chlorophy0 deficient'albtno' mutants was stualedin relation to hormone requirements. The yellowheterozygote '(Su/su) exhibitedan atypical glycolate metab.charaeterized by a higher photorespiratory rate cotnparedwith.thee greenhouse .- hemnzygote recessive',(sulsu). The albmo had a strong requirement - for IAAandi responded linearly overa 1000-fold concn. gradient. ' Tissue cultures of the.homozygous dominant genotype grew well under low lighcl or in thee absence of light. Thus, the lethal albino QSu/SuF can be grown adequately as tissue' culturess in defrned medium contg. 1AA but still maintain the chlorophyll . .. deficiency. . . . _ . ,. .. . • 84: 42481x67ineral'. nutrition of cultured chloroph ~llous eells of tobacco. II. Effectsof nitrogendpota~siuma ealcium/(~61-calcilum),., ehlorideion., and sodium in the mediam onceld growth loshiila• Fumttake;'. Nnmura,.Chivorit Nemoto, Shinichi (Dep Agric:,. Tamagawa Univ.,. Kanaaawa, Japan). TnmaFawmUm„aau NuFakubu kenk'_vu Hokoku197i4• 14, 1-10 (En;t)• The cell frEabiiitv was not inlluenced by Ca 7440-70-2]/I~'M-Cal values of 0001-1.0 in media~ of, N 7727-37-9]/KI7J40-09 /1 = 2'.5 at •;M~ = 40 and'.8t1, hut was prumuted by a higher N/'k of 4.4 in media of Ca/("%T-Ca) - 1.0. The h1g [7439-9a 41iab.nrplion was.auntrolled~by the ratio Mg/Ca.tn the medium while the Ca absorption was not. . Chlnrophyll h1gICA-hIF)was-. not proportiunaV to the total <tg `T~-Mgf cuntent in the cells. Ch-Ma and Ch-MidT-Ste were higheat on media.of Ca/( SI-Ca) =0.1. Cl _<5 mequiv/1. had --little.effecton the cell.growth and friability. Na• <10 mequiv/I, had no harmful effect.un the ce11'cunditiun. . H..Ckhiai
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` : ABSTBACTS : --- ----~-----..._ : ABSTRACTS : 84: 57774u 3oi1 and plant.faclors inllucneing.acenmulatfon ef dYy matte" in 6urley labacco in soil'made acid °,.... C bfertilixcrs., Sims, J.. L: Atkinson, W:, 0. (Agron. Dep., tn, Ky.).~ tr` ~'` x ~ nkA el ' 775-ng),e 8 fi d pti.as to elucidate factors (E '-r Influencing dry matter accumulation in tobacco(Nicotiana -taabacum cv. Burley 21)growing' in soil whose acidity was Increased by fertilizer. Relatively la rveamts. of commercial "fertilizers commonlyare added to.soil in.burley tobacco prodn. - and knowledge of the etYectsoL such addhs: on dry matter aeeumulationmayn lead to increased yields of euredi leaf and , improved uaabilityof cigarette smoke. Samples of soil and plant ""- material a•eree obtained at vnryingdates during the growing - dhillldilH ll ; seaxon an were cemcay anayze.. Varying su peves "~ wbtid'fliiof N NHNOef 0 ere oanerom appcatns o as+.at rates o, `. 90,. 180, and 8fi0 kg, N/hm The addn. of N, fertilizer to Maury "" . silt loam~l w.il with an initial pH of 6.2 'signiGcantlv increased ` t+"'exrhangeahle:Mh [7419-9G-5].anddiv~reasedsnilpH.exchanceable Ca~ r74Y0-70-2], and cnncns. of avadahle. MoOi = ~11259-8fi-9] '; t' and N~POu[ilJmi6'-20-1]. Ezchangeable Mk. and li were little affected by N' fertilizerr at onv sampldate. Much of the _ ;_decrease in exchaneeableCa mav be attrttuned mdeachine with NC>., by exeessivereinltalle early in the season. .hlvidence - idld dlfii5i NH ilfild .ncnle snnteeayy o nlrlcatun ofdn pntrerlize , al tBe 3fi0kg N rate. N fertikzation of tobacarinereased concus. !uf Mn in leaves, Ihtt.levels were notjutlgedGi beexca.•ssivetiu `i';; nunnal growlh. Atendi•ncv existedfnr conrnsq nf Ca and Mg , t. .•[7ta9-95-J] wrbr.divrw<ed by N at a0day.ufter Iran.pbuning .; and conrns. were near. defiriemy harls fbr, Caw at this date. . althnugh excAunxeable soil (Ja levels exeecderl l:dki ppm.. In ~ i~.enntra.st, at 77 davs and at harvest, N fertilizer sieni6eantlr. . Inereasea' plant ¢mmcnr. ot C:d and Mg. Mn ttutens.. in leaces - ~' from hN plnts werr mIv20 fdt% of those in 81nts unft•rtdizrdd with Nl Concnv. uf badh 2 in levesfrom fertilized plut.weres near deficiency levels tur most nf the crowin eaenn. The data suggested interaction of MoOr z and hlu.,and uf Mn with ( a and, ]v(g within the plant Correlation and ret,rc+sinnn annl,v>es -• revealed significant relations nf soil'.measurementh neeutransplanting -and'drymaLLer at JudavsancU of plant constitucntxs and. dry matterat all dates. Results indicated the depression ofdrywtf by N fertilizer noted previously duringg early growth was the~dtrect or indirect resultof't fertilizer-induced snil acidity. 84: S6681z f;enatypicxesponse of burley tobacco (Nicotiana , -• tabacum) to air-curing detached I'eaves.: Gupton,. C: L. - (South. Reg.,ARS, Greeneville, Tenn.). Agron. J: 1973, 65(5), 801-4 (Ena): TMe differential response of.diverse.burley genotypes when tne leaf was cured! detacned from the.stalk was studied.relative to the prodn. of cultivars-w•hose mech.-harvested -, h:af posusses.the normal characteristicsof burley tobacco. Ten- ._ 6urky tabacco cultivars and. breedin8lines tnat' diCfered from each other in plant type. were grown in aspltt-plot design with aenotypes ass whole: pluts and' methods of curtngg assubpluts. - TheT methods of curing, eonsisted'of conventionall air-curing on theatalk and air-curing leaves that,had been detachedCrom.the stalk and strung onsticks: Yield and grade index were detd. for thecurcd.leafof each treatment The leaf web n•as.sampled,and analyzed for percentage N,.a-amino N. water-soL acids,. pH, . percentage ash, K;O,. nicotine„ nornicotine, and cnntent of citric artd.malicacids. Yield. pH, water sol. acids;percentageN and a-amino N were higher, for detached than forr stalk-cured leaves. No significane differences existed between curing methods for precentage KaO, nicotine, or nornicutine. Leaves cured.detached ` were.lower in ashh an& im gradeindex than thosee cured tonventionally. Certain genotypos,.such as.Va 509. produced touch more accoptabletubacco from the standpoint of both visual and chem. characteristics than others when the leaves were cured detached. Pntgressmaybe expected in breedingfor aulti'varsthat produce burley. tobacco that is acceptablre when it is cured detached from tfiesmik. WoLr 6, Nor 6, MARCH 19, 1976 .`84:.59779y Chemical study ofYlurhy loburcaflavor (Ni= .~eotianaa tabneum). Vll. Identiifieatinn und. synlhrsls of twelve irregular Ierpt.noids% nJated to snlrnnnr. including 7,8-d.ioxabicyclul3:2 ilocl:mcand lJ diuxabitvrlnlJ..l;tlnnnune derivatives.. Demole, Eduuard, Drmnle,{i.tde (lii•s. Lab., Firmenieh S. A., t0eneva, Swnz.t. Hidn, f him. Arrn 1975, '58(7), 1867-tl0. (Eng). 1-VI. MeCOCHXH'•CHICH67es)CH:= r `'CHCMevOH; MeCH(OH)CH_CH4`•H(CH1fez)CH:CHCHMeOH. -~ MeCOCHzCHsCH(CHMe21CH:CHCH.titeOH: \teCOCH_('H:CH(=~ CHMez)CH2CH2CH~MeOH, and HOC}ieCHXH(CHMe:)CH:= '~ CHCMe:CH2~,were: isolated fron. Burley.tobacco..their structures ~ detd. bysynthesis~from norsoianadione and~.MeCOCH.CH:CH(=~ -^ CHMezICHO~, andd their relative conGguratiune~ and biogenetic - --'routes dtiscussed: . .. . . . . . . 84:56358g Chemistry of burlcy tobacco.flavor (Nicutiana tabacum). Novel constituents and newer syntheses. Demole, . Edward P. (Firmenich S. A., Geneva, Switz.): lnhCon6r. .Essent. Oils, IYap.], 6Ui 1971, 154. 11 pp:(Eng). Allured Publ. Corp.: Oak Park, III. Areview: 84: 40709d Originrof tobacco. Biochemiba] studies. Kawa- 'shima, Nbbumaro(Cent_ Res. InsL, Japan Monnp+ Corp.. Tokyo, Japan). Kagaku To Seibutsu 1975, 1'3110),.675-80 (Japan).. A review with~ 21 refs. onn thee chemotaxonom~' of the genus.Nieatiana. . T.Tsu1i _- 84: 54885v. Wcatberrlcck.onaobacco Ieaves,, XIX: Si:recning . of chemicals forcont!rol of ozone in]ury to tobacco. Fukuda, Michio; Kisaki. Takurol Koiwai..Akira7 Kitano, Hiroshi; Shinohara, 7•ushikiyo; Tanaka. Yukihisa (Okavama Tob. Exp6 Stn.,Okayama., Japan).. Okayamu TabakoShikenjo Hokoku 1975, 35, 75-85, (Japan). Effects, of systemic t fungicides, methylenedioxvphenvl derivs:. and some insecticide eynernistss on Oi [I0028-IS-61 injury to tobaccoo were detd. Benzimidazole (H [5l 17~2], rncthtl?-benzimidazolc rarbamate [10605-2t-7~].(hiobendozulettJ8-79.4],thio p'hanate [2756J-[16-9[, methyl thin hanate[2350J-05-S) and benomyt lhiaphannte 57986-53 5~and oxathunsfrnrboan [n237-68-t1 and.o:yrarboxtn 5259-881]I inhibited Os injury when applied as soil drench or oiinrfy. Foliar application off methvlenedloxvpnenyl derivs. also protected tobacco from the Oi injury: Inseeticide synertsls. auchas mynslirin [G07-940], svneptrin-500 [13358-I1'-7], SKF 525A' [62-68-0], MGK 26•1 j112-48-i],.S-•f21 [P17-90-2] were.alsoe[(ective. H..Ochiai 00009162
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e r 1 S W ~'Itl~ `LORILLAP.D :;ULD ~SUST SAYS FIRt+I SOUGHT . SEXY J1•TAGE ae~ ~`'GREENSBORO DAILY. NEi S ~Nlarch 12,',1976 f lor c t Ifi t eo ;tpam ttilh a~l of n y heart, ar l had gnc~ ttat corrpnt a lot ot det ~~ ~on: `I na~art~ upany pe s~+~:irstdc oul. ~-;~'?_ ~ ~~.~}r~ite> P t'rr, adcd.sh tas nuft `$ttt r louur.j"~ ,is , of thc Lenaa d uga-~'-' We e pi•tnf in ({ ecm om Shehc' etec her-~'' .br a t~6' oiu ra1 at the' {q] }.{,FOrkC 1tC oiflresof orlllarC ad87ston . ' ai`t"o~ LoCtsa 7h~tres,lnc bccau n yl e dtd not ~ tc`t 1 n.ss Pons`an s< t~ 4t.e>b~ ~ ~n'ca t n g• 1 g her de- : ~ M pu ' oa fr,r pu, t3 c u c m t.d of t''e'.. ,sut,',~" ~~ic Ti;c: a'n ; 5e comp rcs:'is a ecrafied y pnfe~= o a tan ~r aev c rs o she ~~i rc~µb ~:r,,e1 bnr~ s se ret „y n: lhe ica r` C~i.entii <i e is e?p~ ~~L as a hi _t fo~ ^-? #~t, ! o:d Cc~n .E II~r ali; Is_„'r.~.t S;GO ': t. ~id as r: a::a: scraces cooo- . at Io,riler.3 sv':en >he svns fired Jan. ';-~ 31. I;-a ..lcs,'snc .cp' alto a question, she s+a; _ ;;auare ' oMc !ir,; uas gomo ori .n tte icay :~. •'t of 1a;isffs at'tSc plzn[~ incolting marbe .`+s I;°mam' as 30 cmplo,es. '1Lcn, shc uas askcd, -._\rhaLis the basis for her al.'c;utioc ttat the ~ Y:~' cnmpacy was sc:king to p:cscnt e a'yocn -% , tm.lge:" ~ - :"11•cII,.I'm goingby our den;tnert Itd ~-~ :~goingby_thefinancial sert:cesdepartntent.'. _ -Ttere. ur're eight peoplt: in tlhere The two „' oldest people weredisntusea• FV. Ai. 9S cllrraa -aadFrances P. Pons.ssece'botheszr 59.'fhe ~othecpersoddismissed was the pcrsoi mtn a the least scmortty."-. 'Thcn. prodded b,v hcr olsn attorn }~hc cs- `~' 'pressed a belieP,that the desire to pr<~cnl a ; .. .oungimageoflhci•onpaayledtocxr.~t:~ees. -.shuwering.attention on younger women, and - resulted iu her tiein- "slereJ}p:d'" at a;e SC as an -oid-iu!tioned, straight.l.wy ~'.Ifbsc did she catne to fo~el'sheh..d been so cLrssified'' ~-. Shr.sald "'Lbe five clerks in my arca'wcre': :~ very young, very zesy, very ccte. They _^ dressed vqry. mod and cery..wefL, and thcy ., I ,l r - wc ~.ii I.:~,ndsshenlhemenc~me`_,• do~ i;: ~, ;. cspccrall~; thcre µowd ' = bP tafk. T r~~tsomd ;m ttb~lunch.andl-° s r r mut ~ t w, s po:nt that I was~' - ~£ e.cluded. , ~'-M ,,~r r~S'° ~'~ orc da} one ot the gtrls.fdt }.rnd'o .;, ., S+ ba9 about it and she:sud tseJl;how about ~' - ltilrs: Pons and theman lno ved sald let n ~'Rellrnan ta e care of h c And it hu 'my" i LN Jeelings, because'titr ltcli nan i had _- worked for blm all' thoce years andi he had"''' n.:cr touctied me.I had neserr touched h.m N' zrl we had never engaged tn anykmdof ami-~ : < uovsr/ ~~A „~ T , ," :1n;1 t.ha[ u..s jus'. ~l..d, of ~a pattcrl,hat i ,, cc ein edrp;c wm.ng dossnfrom New lor.c j an1 two or thrce from around the plant, th<y . ~is<dldJ ha.e all this talk . 'Yuu~~would go nut in the halls, ar j hcy . ttould.be cuddled up in a ccrer son t+`cre ~ ' talking and ]aubh.ng. *' It tsan sery, apparent lhal I.tvas o d T^er,tliat I was-eot.'tncluded in thc~e -~*'i things„nordid I have any desire to be 4'. tncluded, because I cur'sider mv;cll to be alady, I was brought up:`7n*an e a +r4; '.schcn business was bustness: and I n rd "itvery' difficult to adjust to this." 1, '--Onn redirect queationin;. the ~- bripzny attorneys asked forr more~ details. 'R"ell; "stie replicd thcre i,be =+;~,.;hvo or th:ee girls aroucd 'theoesk:dis- ;' ,.cussing business and one ofthe lce ~ -presidentsout of New 1 or1. wo_td cm e ' ,, in andi the nest.lliiag ynn kro•: they ~. -xould.:.one girli.woui 1 behotd:ag a m,. "' `tel ke-vupi ..dangiingg it. And thcy would be making remarks aboutthe rco.r.s.ar.d >~ < ;`nea, that roomi rcall.y lsn't good, `/ ~~ Did she call such ina:d<rta to the at ,i fentibo-or her superior, SCcfl:nan' 4 a
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~ it. A $-1\0, : F ~p1icJ, .Jir.Wdlman. xasr amare i 1 i1 And "urll, il tcashis bosi, ;" tqo:" Ac4, .t .-d, how camyou call it iks to the attenh n~ t their boss when he . a"js one of the ofhctals who was rl~fm:olced F The lanye , askt ] if she felt such mci- ' dcnts had any,thing to do xilh her firing. 1 Yes.,she rcplied, "Ldid.not fit the med Lnage that seei•led to be what'they were . 9 going for by retaining all the young rcute. 23 and.,".4 ycar,olds -,,.,'; ~y -+5ho added, "To retain ono oi the t uls ~ they tranferred her into a secretary s 1_7 fobandshe couldnrt even type a letter r~ i,~It ++as quite ajoke-" But; shesald the :. ~" .-company would not consider retalmng -.~ ~,j~her, even in a:lesser position. r t~~xTlie trumatic'notit:e that she was ,' firedl she said, came from a vice presl ;; v 'dent,a"'1Ir.:Peterson,°:out.ofthei\ew ~a York offices who read a letter that stat ;; r~ id her i+-ork ++as being "reassiEned, re . d)>tnbuted, son)cth)ng.of'.that n.tturc . "Thcre-was noo conversation she `said. "Ile.read the:letter: It was like+ou were being read your rights. Ikuas +ery "trold, very inlwmane, and there aas no tiargaining, lhcrr was no talking, there ~.was no hwnanity shown. It was just very cold and vcry...just like aniceberg.' J' .Ifcr lawyer„ who saysl he hears the same typc of' complaint irom~ older ++rorkers in many business places asAed tho companyy to rbinstatc.llrs: Pons ; When'lhe colnpany declined, the law .` 'ver senttherequircd notic¢:to the US '. acpartment of Labor of his intent to file ~" ,suit.on'her bchalf undcrthe',Age Dls- ;enioinafiun in EmpluymcnC.A'ct :' Ultim Iteh;~ Ihe filcd lhclc`Vvsuit undu .t66acf mUS..Middlt-ButrictCourtdt `- -;'Crcensboru. It:ask-v-tliecourt tu-order ,'91er reinstatement to the job: and'that* ' the company'be directed not to again ;: discriminate against.her.because of her .. age. ~ ~0~e 6. ?No. 6, MARCH 19, 1976 ~~ m t:ATURE March 4r 1976 Vol.''260,"no.'',5546 P• 49 ~ ~ .~'4.... Mediation of retinoic acid-induccd w growth and anti-tumour acttvity ' ~rtaws~ A (rcnnul) is'a nutnent~essennal for ns{on c'h d. growthl mproduclion and pmperdi4ercnuuticm uf'epiihelul A8 tusuel:.Some rctinal is oxldised.to rctinat acid Uitamin A r acid) la. vtvo but if an arrmal is, pro.ided with Tetinou: acid in place of dictaryretmo4 it ean.only parually'sabsts- .tute for the mnstng retinol vision' and rerro,luction are E v s,+ tmpaiiM'. Sporn er al." baa¢ described two qitemi for evaluating the ocu ity:of reunal, retinote actd and 1heR i"~ analogues in urro..One measures the ahd q of such irom poundt to promotegrowth by determining RV A, Qp1A and -^+ (~ protein levels after addition of'the tencompound.to epider ~ mal cen cultures derived from newtiom mouse'skin; the ~ - other meamres abdity toceverse meuplaua of the<pithehal ~+ . ttlls of lrachea expl5nted to organ eulture from siWmin A CdEficient hanrscers. Retinoic acid is acti.e in both, systems- ": rn addition;, retinoic acid and an aromatic analogue of N.~? .~the acid have.bcen shownito,recerse metaplasia.of mause . °`. '1kin induced by application of carcinogenic drugrs and 1- ~e.pressed as papillomass and lumoun'. The molecular i meeAanism(3) by which relinoic ac_id or..'mtinrsl cantrol ~ -~growth and dlflerentiation- aswell as{.Ihe mechanism of ~ their carclnosutic aliilily, is still unknown but may invohe roq. the specific eytoplasmte bindingprotefns we haredlscovered \~ - far retinol and retinoic.+cid. The cellular rerinol-binding . protein bindsretinol invuro' and inrnd• is present m ~ ~ man) tissues, and exhibits binding afhniues ror eis isomers r~4 yr?~ :of'retinal which M1trellel the gmwth-pramoting aetiviYyof n ~these isomerss in the whole animal'- The cellularretinme 5- aeid-Bindingprotein hinds retinoic acid in rirro with high .- rnecificiqand is presenrin normal rat and human'organs" ass well as a.me human caneen". The twn rrotcinc hase ~` ~,been separated phyaicallyand purified IoMfold fromnt ~tesus'. There has also been a prellminary report of a retinmc acid binding. protein in embryonic chick sAin f~ tn our imestigations into the mechanismH) of anion of ..tctinot and retinoic acid we have examinrd newhurn moum ~akin, hamster trachea, and cM1emiaally induced papillomas ; of mouse skin for'Ihe presence'.of the cellular ret{noic and '' binding prouin. In addition, usmg extractsof mrwuskln ~~ `` p.pillumas. human breast tumnur, and a tAlg1-fold purified ~' nreparaltort fromm ral tevtis as xourcesfor the bindingg pro- tein, we hase examin<d', its rclatisee affinity for some ring .y 1 analogues d relinoic acid IFig. It. In all cases we find that Y~S the bindingg charactcrlstics nf the protein towards the v.analoguea -orrelate wiih the activitYnf thecompnunds in : the aava.w mme.nT Spnrn er af a, well a witb report d , -` Iwnour-inhiAningaclisilY 64 Y .a.~! .e
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ABSTRACTS ABSTRACTS. i 84: 55244% Effects of 2-chlbroethylpfiosphonie acid (CEPAi• m~•- at: 54079x Evidence fbr ucorttral locus for the stimulus dl t><effect of ni l t b (Ni i t b )~ d d h ih ''' b n o aceo cat ana a acum a cure etac c cot on ur cy e: tirhecht NIllik .t•r,. Martin.;. ,enc,.Peter (nep, • ''-from'the stalk: Gupton,. C• L; Nichols, ®• C• (ARS,. 1'barunauL Univ. Nelboarnc•, I ukville„ Ana,l. h.5rr: J. .. '"Grecneville, Tenn.): Afiron• J. 1973; 65(G), 1006-7 (Eng).`Pfturmacul. l975,. 31(U. GS-73 " (hng), In rats afte th r ; ptiysioL immatureburley-~ tbbaccoo prior to. harvest and curin~ ,i ~ ~ N . detached from the stalkk to alleviate this immaturity. 1(I50 •r ~~ °,_` ~ r'.. . e I-~ 2-CAloroethytphoxphontc: actd(U~ [I6G72-87-0J was ap hedd to: '+ - 1 . , . .., ,. .. . mg/plant) was applied 2wreeksafter topping and4 days prior to ha:vest. After rurmp,; yteld and grade index were detd•, and, leaves weree analpzed: The methodl of curing' significantly, • • . , . .;aa .. "affectedd vmdee index. percent total N, percentt a-amtno N, percent nicotine, and pH. I'treatment effects were statistically- sign~ificant for percent total 9; percent a-aminoN;.and percent. ". ash. The level of each of these' constituents was significantly' closer to that of stalk-cured'd tobacco after Ieaves.euredldetacAed. + "flk hd bttdh 1: Thltidit rom the staaeen.reae witese resus.ncae, - i~ that somee important chem, cnnstituentsand phys. charaeteristia:. h-"aremodified in a desirable direction byF treatments. However ; - . :- there may bee detrimental effects,, such asoR-flavor of the •.i'j• "- smoke, assocd. with li treatments which wouldipreclude using the~ .._. .: them. ... ~ .. . ' . . . , . . . ~: ,>. . .~84: SGGLc Pyrofysis of ehitin. potential tobacco extender. ScMlotzhauer;11'illiam S.; Chortyk. Orestes.T.; Austin, PaulIt. ..(Tub. Lab, AftS. Athens, Ga.). J. Agric.. Food Chem. 1976,. •.24(1), 177-80. (Eng). Chitimn and tobacco were. pyrolyzed sep. d iditd idetilditi Th pyrolyxnleswere ann amx. unernca conons.e. fractionatedand analyzed for neulrals; bases, and Except for acidic products, produces carbnxylicc acids . _ much smaller quannties.of pyrulytic prrdurtz than tnbacro and .' indifferent rntins.. Ch+tosan was also pyrolyzed to.deto the effect ~ of dearety!ation un: the carboxylic nctdl profile' of the chitin -' 'pv rolyzntc. It wasroncluded that both,chitin and,chitosan could ecume suitable tohaccoextenden __ , . ,. . ..,, ", R ..84t54891u Effects of oxoneair pollution on nitrogen constituents, pli•.. and watcrsoluble ash of afr-cured'tohacco leaves. blenser; H...A.; Chaplin; J..F. (Beltsville Agric. Res:.Cent.; ARS. Reltsyille, Nd,):Tob. Sri• 1975, 19, 115-18(Eng). Pub. in Tubacco;,15, (191, 70-3. Weather fleck caused bvOs (10028-15-6J air pollution decreused the alkaloid, sol. IV[7727-37-9), and nitrate [1J797-55-8]icontents'of Gcld-grownn tobacco(,Vuotionarabacuml leaves, and increased the protein N levet. 03 fumil•,ation of tobaccoin environmental chambers' decreased the Coliar nicotine'[54-11-5J and water-soL. ash . content, and raised.the fuliar pH. : Sit 56G97] Plasticizcr blends for tnbacco smoke filter rods and' filter rods bonded by such blends. h7orie• GeruldP.; " Slnan, ('ephas H. Def,Puhl.,.U. S. Pht, Off..'1" 9J0;(IIIG (CI. 1$1-167;.:12ab). 04 Nm•1955. Appl: 47.5,144;. 91 May 1974;. 6 p't 9'he prepn.. d pb,.,licixrr hlrud' fur bnnding lohaccn smake f,ltcr r+wls.formttl frum cellulose nrel:ucdiihmwnln and cumprising ^•4U-709o: (wk) triucetm and. ^•a0-G0'ie(wt.) . ut' a luw, vnpnr : pressnre'esterselected frnm amnng.triethy9 ritrute, acetyltrict= hyICltrate,, lrimetbylul propane triaeetale. 2 2:4'-trimcthyl-l,3~= prnt:umdiul diitcetuacerate. mid 1,3Ifntanediut:diacrluarelnte3 is dcseribcd. Tlir nml. of Wend upplied tu the filaments is -6 2l1"/cA uf their tvt•, preferahly 6 11%. In nn rxaomple, f,lter rtals were prepd. from tow ron14. cellulnsc acetate. tiep, srctinns of Ilie Inw were spread and *pr:nvd x-ith numnf'Ihc blendkuf trianetin. 1'he. Imvw,ndr,twn tlqou,;lnmhollow tube and t.hrn alluurd tucure(ben,me tir,n): Che firnmess'of.lhe. bnndrd rods wns eomparcd wilb thal uf rods .pracod with Irin(ctin' ninun ur - with onuof Ilre high Ik,iling e•len. In alll cases thee blend produced Grtnrods in. 1 Itr. (rigid in,"_ hr); VoLr"6, No, 6, MARCH 19, 1976 Urtt{nnnfnirnlinrU)[51'11 r] 1 entramrint th ( li , u en nr nr . correct rnt nf a'C-maze resullwi in termination of a U.titirA,sh,ck. .,.When s;tline was ndiuimntercd, entranree inln.Ihenppryite arat ~ a ws rewarded hyy lermination nf shnck. A h'ir,'h level, of'. discrimination between Cnnd salinewas oblained and the degree " of diiitihd d scrrnnaon was us. tnoccreace as the I^ngthuf tiiaeperiud betveen I admin:strr.tinn and the.lestofdiscrin,iration ., wasincreased.. This declinee inn discriminat,on war closely , correlated with. thedecli•te in brain levels of 1in thee cortex r. ,-.sugt.estingthat the stimulus effect of f is directly related to the eoncn, of ] in the cortex. .. ,. .~ . I5'. .. ,i.:e l. , "84::40945c Scparatiomof lipids fromtobaceo. Fiore,.Joseph V. (AMF Inc.) Gce. Often. 2,i1.0;t1:e (C). A2-IR), 11 Sep 1975, I3riL'. Appl. 10,470/74, 08.?llar 1974; 15 pp. Extn. of dry -; tobacco with suitable azeotropic misrs", nf a lower hydrocarbon :~ and a lower alcoholl removedl snme 8090% of. total lipids and - relatively little of desirable cnmpnnents. Ale. content was .. •• 15-30% (max. 50) by vol. as in hexane: isoPrOH 8020. Solvent •' couldhavee up to•12'7: Hx00 if no. phasee sepn. resultcd. • . ...eaoy' W A Pbd 84: 59820e Ramanand'infrared spectra of nicotine. Aslnnian, Dimitrina; Lautie, Alain;. Mankai, Chedli; NalkansK It1inko (Lab. Phys. Solides„ Univ. Paris VI. Paris, Ft.). J..Chiin. P1q:r. '- Phyx: Chim. l3io!• 1975, 72(9), 10fi2•8 VFr). The Raman.and ir spectra of nicotine and itsmono- anddiprotnnated derivs, hada no. of vibrations whichh were attributed to the pyridine and pyrrnlidinerings: The spectralvariation..between Iand: .I.HCI, the mostt active biolog. Inrmin aq- snln., weree dueto the - pyrrolidinrring:. A comparisumof the spectra of monnprntonated -~1 andacetylcholine sbmes thatthe pos. N of the mol. is the most sensitive to changesin.the phys.,state. 84: 55137q AcOion of nicotinron chick embryo heart,ccUls cultivatedl in vitro. Peirone; S. (Inst: Anat; Anim. Dornest;, " Univ, Torino, Turin, Italy). J.. Submicrosc. Cytol: 1978, 610Y, 339-52 (Eng). , Nicotine (I) [57-11 SJ (!1.23' mAf - 615: pAf), f -when incubated with chicken-emhryo heart for.. 2'-66 hr caused -extensive dnmage: to sume urganrlles„esp• qm Chlgil¢nmplex mtd the mitocbnndria.. bllecaron microscupic and cinemicnre. studies revealed'that I caused n progressivc dilation ufthe cistcrnae of the Colgi cornplex; and lhee ntitnchondria. Vacuoleswere evident by 30min after contact'with: a; nfter:t hr the vatvulesocatpied a wide area of tlice rytuplasnt. SigniGcana fragmenlauun of the rnitucbundria occurred with grnduall decrease in size. Thcse micrnscodral Iesionswererevened to.a large extent by washing , and incuLatimt with fresh 1-iree.ndtlme nsediumi .
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; ABSTRACTS ABSTRACTS 84: 422,Wa Aroma composition for food and loliacco: Flament. -~- Ivon (Firmenich S. A.)Sw•iss 568.722 (CI. A236, A24B); 14' _ Nov1975, App1.3396/71, 09.Mar'1971;' 4pp. Tliiazolidineaof >t n Nu ~ -r ~~ formula~~ I, where R'~ is H, a Cr-Cs hydmavbon; or an aram., group, arc used at'0.1-10p pm as aruma.addilivesn for feed, Ond,. . or tobacao. Thus: to udns, of NaCI 0L ur a cnm. vegetahle. protein hydrulyntte 1% were addedl a soln. of 5~ pyraxine. ' aromatizing agents in propyleneglyrnl. 0.01% and I! of the 'kdkw:inG'1 prep,vhhm Idrdinr ['d1ud1-Ill.tl],2i.wrpa+f{vlthiazrdidine . ~2•f0.i0-11-1 ]:1 hnr.fthlacotidinr (2illtt%-50-2J, or.2 isabutyfth= mralidtne [69fi-70-8/ at 5 ppm by wt tu pruduceorganolepticee l ii( mRdf (mdfit) amm•t-taite evauallnr r~eat-nut. nlm; slure: acra.atc1, . grain (harelnutor mcat aftertatcte);or chornlhtP resp. . r ' 1t ~}IG}1 Y1.ISN 1 n ('n" . t rovJ . ~ ! krti" c~ii~ I, .. ~,r,. :i . 84: 39555u Effects of tobaccoand tobaceo smokeconstitticnts <' on oelli . multip lication in vitro. Pilotti, Ake; Ancker, liJss; -: Arrhenius;. Erik; Entell, Curt (Wallenberg. Lab.,. Stockholm - Univ:, Stockholm, Swed.). . Toxicofogy 1975, 5(U, 49-62 t- 4~(Eng). The inhibitory eflect of 256'tobacco.and tobacco.smoke _'r eonstituents on, the growth of ascites sarcoma BP8'cell , eultures '(asa measure or toxicity) was measured at toncns. of 0001-1 ~-mM, The effect of' penetration.distribution, and microsomal :. metab• of the cnmpds, was not taken into~ account., Unsatd. :ddehydes and ketones„phenula, and indblea were the most toxic ' '~eompds: The good correlation obsd. between function groups , ~.. and toxicity permitted prediction of the toxicity for a compd: of known structure wttliin.the range of.functionalilies studied. 84i 40915t Role of color in theformatian of quality of tobacco of theorientaLtype. Belyakova, Z: P;D'yachkin, 1. ' 14 Burlakina, A. V:. (USSRh 3-1 Vscs. biokhnn. s'ezd; 1974. ~Ref..nauch.savbshch, 1974,. (2),233 (Russ)FromRe).2h., Rio1:.Khim. 1975, Abstr. No. 11F3174: Title only [rans]ated.. 84:409I6u ESR studies ofcii.aret tobaeco,-smoke, and ashas. Scott, T. W:; Chu, K. C.; Venugapatan, M. (Phys.-Chem. Leb., West Illinois Univ:, Macomb, 111.1., Naturmisaenacha/ten . ' 1975l62(11),532-& (Eng). ESR studiess of the ash, smoke, and - tobacco,of cigareta revealed the presence of manganese. It 'ppeen, that all ofthe.manganese found in tobacco is not of plmtt origin; a significant amt is rontributed by chems.used in dusting tobacco plants. However, it, ianot certatm that the -' volatilization ofthesexhemf is the.source of manganesein:cigaret .. smoke. . . . _ . . .., _. ,; .. . .. 1 ..._ . .... 84e 40738n Determinatibnof cadmiurwin tobacco by atomic absorplion spectrophotometry. Windemann; Helena; Mueller, U.(Kantonales Lab. Lebensm. Trinkwasserkontrolle. Bem, Switz.). Mitt. Geb. 6ebensmitteluntera. Hvg. 1975, . 66(aD, 64-73 (Ger). Because of interferencex. Sdtfferent eshing methods were studied (dryashingima Pt crucible at --500°, dry ashing in a low temp plasma vessel in a frcon-0atream, wet ashing with HNOrH_•O±, wet ashing with HNOn-HzSOa-HzOt, wet ashing with HCIOJ:. While dry ashing at 5000 resulted in . Cd1osses, thelnw temp...plasma methtdcompared well with the results obtained by the wet ashing methods. Cd was detd. either directly inthessh suln. or in the methyl-twlbutylIketone.ext, of . the Cd-dithizone com lez. The Cd contents of various cigaret tobaccos are tabulatedP TbeCd content of ^•1.4 ag per cigaret agreed with most literature referenres• .. .. E• ¢.Gensel VOL, 6, Nor. 6, MARCH 19. 1976 I 84: 407271t Purifying tobacco smoke of carciuogenie pol= ycyc lic aromatic hydrocarbonuFedorchenko, L M.; Kuchkovskii, B. S». Pugin. V: S.; Komienko,. P..A.: Lunin,.L. S.: Palyura. A. (USSR). Visn. Akad. Nouk Ukr. RSR 19751 (9), 70~2 ~ M . . (Ukzain).. Cigaret smokee temp. (measured'', . after leaving the 'dgaret filter tip) at the beginning of smoking did not depend on 'the heat condiof the fdterasthe 1st prutionsof tobacco smoke werem cooled to the ambient temp: by the penetration. through tobacco layer.. At the end of cigaret smoking, smoke temp. was dependent onthe filter material and wass higher by 9-li° from peper or. cellulose acetate filters than frommetallie filters :lsintered Fe or Cu powders) and benru(alPyrene concn. insmoke ' from.metallic filters wasup to4-foldlower, .. •A: Mrskos t g4:56679e Determination ofgold and arsenic in Indian , tobacco leaves. Purkayastha,. H C.t Bhattacharyya,D: K. ,. 'Nucli Chem. Div., Saha Inst:Nucl. Phys. Calcutta. India)= -~. Radiochem. Rnd/nanoL. Lrttl 1975, 2361], 43I-li fEng). Two rvarieties of.lndian Tobacco]eaves were analysed for Au and . As by neutron activation. Nlmttona rustica variety from North Bengal contained 3, X I0-1 ppmof Au and 4.0x 10 3 ppm of Ae .. and the N: tabaccum variety from. Andhra Pradeshh contained 1.26 X 10-t ppm.Au and 5.1 X 103 ppm As. resp. Unlfkethose . in other countries Indian tohacco.Ieaves were enriched inn the Au content and depletedin the As content. The soil~ of North .. Bengal waa.richer in Au than the soil of Andhra..Pradesh,and the ' •.• amt.,of As in both soils wasphysiul insignificant: . . ,.. 84; 5667:Sd Chemistry of tobnceo constituents. Oxidation of a-ionone and the acid-catalyzedrcarrangement.uf 6-keto-,.-ionono. Davis, Daniel L.; Dtc:crnl• Kcnncth L.;: Jurd. Leonard (M1YRRI., Altti, Berkeley, ([alif.):.. J, .4Erir. ~Airal (hem: 1976, 2401, 187 9 9: (Rn•). Abu:.vnthetict,vpesy"nthe.is , fram.4-f2.fi,6-trimelhyl C cyclu~jexr.n t yh:-A liuten.2-une - (n-innone).ufsumeofthecyrlicerr,npd) whichuccttr, in.tubacrnr d and uthu.r slxcit•s has bcun inccsug,ntd,Okidn.. of a1iunmu• gaveb•keto-a-innone:4-kettrit-ionnne,anrldheG+luutncunstituent, ~ JI-mnono epoxide. In aq-org. acidv: 5-ketn rr iunune cyclizes tn 4,4.7-trimethyl-3,4-dihydro-2PI/1) nnphthalennne,, wiiiih nn redn. and dehydration yielded annthernatural pruductt of tobacco, 1,2-dihydro-1,1,fi:-trimethyln:r,:)ltkalenc. Air oxidn. of ; 4,4,7-trimethyl-I1A-dlhydro'->(lfl)-naphtha!enune gave 4A,7-= - trimethyl t 4-dih}•dro 1 hydroxy-I'naphthalcnune which has . ..not hcen desrrihed previously. . _ , 84: 40918w Chemical propertics of tobacco leaves as affected ..by carbon.dioxidedevictdon and light intensity:. Rager, C. Ilavid,. Jr.: Weeks. W. W.; Downs, R. J.;. Juhnson, W.. H. (Agric: Exp, . Sln., North. Carolina State Univ.. Raleigh, N. C:). A4ron: J: 1973, 65(6).,988'-92 (Eng).. Flue-cured tobacco (Nieatianatabacum) rapidl9 depleted C(L+from a 400 ppm ambient level of 200 ppm: W hen compared with plants grown to maturity in an atmosphere continually adjusted tothe 400 ppm levell by supplementary COz uhem. a.5aya of leaf constituents indicated lesser effects off the. COidepletion than anticipated. The eontents ofstarch, sol. carbohydrates, and polyphenolics weremeagerly depressed ih a COrdepleted atmosphcre. A redn. in light-tntensity below.322 hectolx had a greater effect on accumulation of these compds. than did CO2 depletinn. The COr depletion did afl'ectthe compn..of the soi. cnrhuhydtate fraction ]n leaf tissue. The COL and light treabnentsin this6 expa were tuntinued until an advanced stage of leaf senescence. Both C0r depletion and reduced light intensities prolonged the growth perial of leavee befnrethe:onset.of senescence.
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Dur. al r.rp...t: Call-Ne. LIBRARY - LORILLAM RESEARCH CENTER POBI 21533 GREENSBORO;: NC 27420 Furuwol . .. . - AulSor (ar yariadleai Gtla.at.und ysm) LU. (.rith outhor 6 Pcy. (ar p.rlodical cNd.e) (1nd..di5an, plcc.6 dclo) 11Ih(. odition only Y.ri6.d in (er .ourc. o( n!.r.nc.) ma.drevlarlny ple¢a..upplT ahLUe41m . aHatd ccpr a coa dc.. nor .:c..d S Da'. ol r.-.nL Coa.::a - LIBRARY LORILLARD RESEARCH CENTER POB 21688 GREENSBORO, NC 27420 Furus.o! .`dulhor (cr podediedltitli.,.nl. and yaar slataa D.pL. - ~Slelua ~ - ~ D.p6 ~~ 'REQtlEST SEQUEST, EU.(withaulhor6'Pa7.rlu[p.riodievl'articlht)(Iod.adltioa.pinc.6dam) .aThia.di4cnon:y V.rili.d la (arsoures of t.br.aa.) - - - ~ . H aaa•drevla8ary pl.a...uppiy alfivaGim LjHand coPy.H coa do.s aol soe.d S LIBRARY LORILLARD RESEARCH CENTER. POB 21688 8! GREENSBORO, NC 27420 TWY (.ilh~auhox,6 po9..lor p.tladienl.a+lldo.) (IncL edition. Plaeo 6 do1.) Vorilled ia (or.auma of rom..nca)'. - R aaa.envlalinq,.ploa.o mp91y' 064aoGlm a~,liard topy.Il cost da.. nol o.a.d S; VoL, 6. 0o,,. 6, MaRCi-i 19, 1976 . .. . . - . .._ -. ..'W^~r ..4 ~'~h/'.
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.' 84:.4Rrrb7t (Fplinrization theoryop preparative production 'rale in open. tubular gas chrnmalnraphy, licrys;' T S ; . . -Smuls, T.. W.;Dc Clerk K. 1Dcp Phvs. Chern., Univ. Pretoria, .'Pretnria S. Afr.): Srr Sci. 1975, IM•0, 471!87 (Eng). ~' Itruviuuslyderiued equntrons relalingthe.DrrHhtg rate tn operating ~ prtiihlid .annfeersn prepnratve crumnury;: amm appe liropen tuhulnr columns. '1'he pnsln:.nte i.n tintrtihn of 14 variablrs , '-oll extrpt5 uf which can.be regardedias panmeLers with value, ',=frxed at representative Ievels, and.can be interpreted formally as r:a hypersurface in6-dimensional space: The max: prodn.rateis :. _analtzed' forr those cases im which lhe column rndius r, cnd .. pressure p area given ana mee column length t is. acpenaent, rr :endl are given and p is dependent,. and.f and'.p are given and!rr ~ ie dependent. _ _ 84i',5E03Gt Precofumtt for high performance liqpid chr= I iomatography:, Paehia, Lawrence A.; Kissineer, PeterT.. (Dep. rf-.Chem., Purdue Uiuv., West Lafayette, Indiana): Anaf.,Chem. 1976, 48(U,. 237 (Eng). A. precolumn of simple desigm, is -.:;described for use with com. liq. ehromatag. fittings. The short ~ ,,;J, .(1-2lcra), easily replaceableprerolumnis intended toprotect expensivee highh performance anal. columns when samples of biol. `, origin areatudted. . . , , . . ~ 84:52967z Mass apeclrogrephs.and runcollector systents. [ Bingham; Richard A. (Associated Electrical.lndustries Ltd.). , Brit.. 1,412,8d9(CL.H01'JI, 05.Nov197.5. Appl. t7,589/~73, 12 '.Apr. 1973; 7 pp. lon bcamssUikeparallelw•irrs fh lhe focal _. planee of the spectrographand the emitted secondary electrons are captured byscintillators, each one disposed and charged toattraM only' electrons from a specific wire: E ach scihtillatur has an assocd. wave guide;, photomultiplier, and display device. The ion collector wires intercept ions of a sin-de mass-charge ratio.. ~.,84: 53595p Opcn~splitconnection of glass capilihry.columns . to msssa spectrometers. Hennebcrg, Dit Henriehs, U.; ' Schomburg, G. (r'Max-Planek-Inst, Kohlenforsch;, Muelheim, - Ccn): Chromatogropiria 1975, 8(9), 449-51! (Eng). An open .. eplit-type.conneclion is described with a Pt eapillary as the inlet hne tu themass.speetrometer. This connection device:is suited . Lo various types. of. culumns,, but esp, for gless capillaries. , Advantages of thee open splitt are: a rather high yieidt high flexibility with regard to eolumn paramelers;; andi uptimal "reliabiiity„because the npen split requrresno vacuum-tight seal of the column to.the spectrometer and nospecial gcumetry of the column end. An addnL feature,is.the possibility oGsuppressing vcrylarge.(solvent) peaks:. . ,. ^ . , ~ 84: 53J7fa Preconennlrtnlion of certain anions using rcngents Immobilized via sil.lnlion. l:eydon, Dunaid' Il;C.uttrell„ G: Howard; Nunidez. William K.;. 8'crho, Dennis.B. (Dep. Chem:, Univ:.Genrgia; Athens. Gn.).Anal..C'hnm. 197G;. 45(1)„67-70 (b%nr.ls Functional groups were nttnclied to the surface of eontrnlieti-pore glncshends via silhintinn renctiins. Oxynnions suchac arsenate. dichromnle, selenate, molybdate. tungstate, and vanadate present nt the ng/mt concn. level can, be recovered by osing contrulled-poregiustreated with N-d-nminonthyl-7-ami= noprupyltrimethnxysilane (Dnw-Cotning.Z-G020): The recoveries were investigated asa function of time and pH. Byplaring 1110 mg of thee treated glass headsin a small coluntn and pumping test solns. through the column at 50'ml/min,.an av. recovery'of 103fkwas obsd. fur:l.5 ng/misolasd of selenate. NoL. 6, iVo, 6. MARCM 19, 1976 - 84:57575gDetector for liquid chromatography. Liteanu, !`Candin; Nascu. Iforea; Popescu; lonel C. (Universitatea , -•IIabes-Balyai") P.om. $7;J18(CI: G01n), 10 Jut 1074, Appl. '67,067; 28 May 1971; 2pp.. A detector for liq,, chromatog. employs a membrane electrode havingg as sensitive area a-'^ AgxS:Ag• selective ceramic disk held in place by a Plexiglass holder, withgrounding.and ref Pt electrodes and with a.deliverv channel Perpendicular.tolhe electrode and the outlet channel tangential to the sensitivee surface. The detector has a, simple 'solid, eonstruction withh reduced dead . vul. and background l noise, `high sensitivity, The de;ector permits. measurements without --...arnplitication and is sensitive to iuns such as Ag+, Hg•, Cu2+, Cl`, '` Bt-, f-,SCN-, CN~, COir.-ar04s', Cr0'.r-. - J. A. Russu, 84:53590h, Other heterocyclic compounds Davidek, J:; " Janda; M.; Stibor, h(Dep. Food Sci. Anal., Prague Inst Chem. . Technol., Prague, Czech,). J. Chromatogr. Cibr. 1975, 3(Liq. Column Chramatognh 895-926 (Eng). The use of.liq.roolumn .~. ckromatog: forr thesepne of y-pyrone~e derivs., anthocyans, :a0atoxins, and mycotoxinss and'other compds. contg. . heterocyclic . OI suchas porphyrins and related compds:, indoles,.pyridine and ..'; related compds.,. polynuclear azaheterocyclics, and complex mixts: of heterocyclic compds. is reviewed with many refs. . „+ .. ' 84:5:f59Gq Origiriation„developmcnt,.and potentialities of.glass~capillarycolumns. Desty, D: 1{. IBc: Pet. Itc.. Cent., "~ Sunhury on Thames/hiiiidlescx, Rngl.). ChromntuprapKia.. '- 1975, 8(9)' 452-5(I•:npl. '1'he dcvrlopment nnd, perfircmmnce uf.. :' eapillary drnwiny' machinrsmtd. diffiadties af atatiupcapillaries,- with thin stable fihns of involatile nrg:liqs. are discus.ud,Ncw'. ahapes for. eapillaries: are suggested, Ilat' rather than the usual .round columns, nonuniform crinkled columns, and specislly shapedd regular. eores,. which may he drawn rntoo thee tubes. ' Anodized alumina wire cores scem para.icularlyattractive.for this . purpose. High-spt•edgas chrumatog: is reviewed. -. 84:5G112q Rapid determin:rt'ron of cadmium in biological tissuesby nticrosamphag-CUp atomic absorplion spectrUmetry. Jackson, hennetk\S,; hfitchell,. Dougla.(L ('Div. Lab. Ites.,. New York State Dep. Health, Albany, N. S`.). Aimt. Chim.. Arfa 1975. LU(1) 39°d5 tFn;,l. A,nutru.unplin cup methnd, of at..a6xorpuun spxtn metrt was a rpl;.dw thtdrtne of Cd in brul.lissucu b.truplepra.pn:.mtolret~ hunmrxniziq; aknnwn wt. of the tiavuewith a knuwnvaL t,f w•ater; pijtcttiirg n suitablediln,l of the homngenate nun a mu.r.,smnpbug :rup and dryirtK:Aq etrhbratiun ctds, were u.d Seusilr.ilv, lim rr rmpe, nndrr•pnalhcihility were ndtqu-ttt fitr tht.s tpplicatiun Lhe melhad .. issunplrnndqu;rk. . . . ... 84: 40JG0h Separation of synthetic mixtures of sugat4'and . of sugars in body. fluids with a high-resolution carbohydrate analyzer. Voelter, lti'olfgang; Rauer,. Hermann (Chem. Inst.., Univ.Tucbingen, Tucbingen. Ger.). C/in.Cherrr..(Winston-Salem, N: C.)' 1975, 21(13), 1882-6 (Eng)i By useof a specially designed gradient~generatingsystem af anion-exchange resins of 10-20:nm particlediame and of an orcinol sola.in cnncd. H2SO< (4I g/literl as detection reagent, a mixt. uf'.. 16 carbol.:drates can beesepde in < 4hr. Thelintit.nf detection formostsuhgars is 0.1-2.0nmule. The detection reagent is stablee for months and does not become colored. The reagent mixes with, the column effiuent in an exothermicreactiun and allowsuse of relatively short mixingg coils. The anal4zeris appropriate:for investigating body fluids rapidl4and with hiehsensitivrt9.
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-ABSTRACi S - 84e63976c: Fracture morlee determinations by' scanning 'lrsolectron microscopy- Sasaki;.G., Yokota, M. J. (Lawrence .P!'r~) BerkelcyLab., Univ:California. Berkeley. 'Calif). AfetaUogrnphy 7975„ 8(31, 265-8. (Eng). A method of surfacee prepn. is described' for the titlee process. A small portion of the fractured ~ rpecimen is removed so the fracturee surface: is at an ohtuse anKle ~' ~:'(- 120°) with respect to the surface taM be polished. The -^ specimens were then mountedin lransoptic powder so that the fracture surface..isprolecled and a polished surface-roughlx ~t'~~r+--normal to it can he prepd. It is then possiblee to free the ~~" a imenn by breaking opem the mount without use: of aa eoMent scanning electron.micruscupe was.used uith secondaryrelectron V'1'emission and with thespecimeni tilted to obtain optimumfocus 6t-land contrast nnbothn the fracture and etched surfaces. Examn. _;J`;6 of the intersection of the fracture:surtace and the polished-etched aurface shuwed'the exact fracture path with~ respect to the .~; r0h•microstructure.. Scannin°g micrographs of an8'e-12% Nii alloy "r-r•is[56668-89-4] produced tythis.technique areprosented and - . ~ discussed. . . . . • ~ ., ~- ~ . D. K. Dygas -t..-84: 615960Continnoui process for mahiuq fibrous cellulosee c acetate filter material. Caputi,.Art]mr, Jr.; Wun^;.Thomas C: ' S: (Gallo; E. and J., Winery) Sl African 74 0t,747(Cl. E'?9j);. ;'24 Jun 1975, US Appt- 408.296, . 23 Oct 1973; lN pp. -: One gal: of'3%: cellulose acetate (1) (9001-35-7) snln.infi.c^C0: , was pumped at roomtemp.m and 2.6 ft/secc rate rnto.a glass tee;. elurried witb FL0 at 680 having 1.tiSftJsec :lowrate.(Hr0-solm .--ratio-15:1), sheared! with a 3500'rpm0 centrifugal pump.w•ith"blade: impellers, and drained on: a 60-100 mesh screen to give. ~ fluffy 1, with which white wine was filtered to give a clearhlt.rate ' . wilhturbidity<0.1ppmSiOa. Seluw4.6A.ft/secH201 flowrnte; and at IixO temp. <30° and >60° II frbersn wereobtained which provided poor filterina.media. ~ .- , ' . _ SJ: 6U:i88s Micruporous cellulusae acetnte Rlms, Matsui, Trishihiku:. Mmmibe:, tieiirhi: (itxlb, Kenji (Asaki Chemical '' ]ndustry Co., Ltd.) Jap:m. Kokni'. 7:S,I3G 1•ilC ((:I...IXt8;11, 'wl Oct 1975, Appl. 74 42;877. 17 Apr 1974; d)pp. 19cndin0'.a Inict. - enntg. 3-40 wL % relful(Mearetatete) ['JpOt.-33-7] (-062.57. acetylated)' in m good srd4ent. e.(, h1eaC0, wnh<2110. wt.°k. " (lktsed on Me_CO) h1i•C111 [67-56-I].(puur suli.rnt), _<21I0wt. °/° (based nn 1) CaClr [100f1 i2-Jl or \lg(')- [u8fi411-3], and 60-120 wt. '7s (basrd nn h1oeC01. IiuOli'. [71-36'-31, aq. rarcharnso (I1) . [id-A. 4]. cdh)•fl ether QI(lt-.9-71,CsHs ' [7I-43-2]', cydulrexnnr,l [I IIS-93'.Ul, dibut.-! phtlialntr [6J 74-21, or Tctrnlin [119-fi.l'-2], I'orming shrels Ir..m the rr<ultingblcnds followed by'crxlgulatiun in dryire-hlcOll at-90 tu:+I0°guve mlcrupurous fihns,. uscful liu filters. 'llhus,. 100 : g 1(Sd% - acetylatrdl) and 811 g CaCli and Mc COblh1, Is1r0111 2t10; nndd a mixt(contK. It.and 11akat,1:1 wt.ratiu) l:dl.ml were miirrd. A . film.formed'm frnm the resulliul: mist. was rnagul:und ina hath conig. dry ice-htrOH uU -7G"to give a micrapurnus filmwilh pure diam.,1.2.u lfrantd and 1.°_.u tbuckJ'unti pue cnntent'Rd9a:, cnntparcd w.ith(Ia15 11r.()0 M) and 6Y'9for% alilm prapd.. from a aimilar.t•otnpn.w•ithouL:IL _ _ VOL. 6. Nor 6, MARCH,19, 1976 84: G1769p Temperntnrevnri~ation n•ithin acignrette ' . • ha ;d'eombustion coal duringIhc smoking.g cycle. Raker, R.. R• 1;•r cACmupvRes..Drv, Cent., 6r. Am. Tob. Co. Ltd.. Soulhampton, . r:En&IJ. High Temp, &i: 1975, 7(3F, 236-47 (F.nc). The " ..vartaLons.of the'tempe distributions of both the gas and solid phases within the combustion coal of a burmngg cigaret w•cre • . detd.,asthe.puff:andlsmoulderperiodspmg~tv. Themelsuremcnts were made using a thermocouple and mt infrared-transmitting t.e. .fiberoptic.. During the interpuff smotddor period,, nearr thermal „tt -, eluill between the 2 phases is attained throughout the cnal. The !n: highest temps:: (780-90°)occur in the. center of thee coal. -: However, during the puff the 22 phases have very different't temp. -- : ;distribulions nea thff thllhhh Bre surace oe coa, atoue tey ore il i i h m ar6 n t i s e centrah regions. (at •V850")L The highest't salid r.phasetemp. (-900°) occurs:atthe coal periphere) ju.a.in front of.the paper burn line, presumably where the air influx into the ': coal isgreatcst. The.gas.tempe in the same region is relatively i.e eool (varying between 605 and 770° as thee puff progresses). ' 84: 61G39wWater content of sugar, Schneider. Ferdinand; -- Rmmerich, Albert: Ticmanis, Uldis (Iirsl. Lnndwirtsch. Ti•chnnl. Tech. Univ. tirnunsr.hweis. Sraunachwetg. Gec). ischer tilnr• 1 he -0.0U1!Y.) nith, thine of modifiedl Karl F modified hnrf-Fischer litrn. nmli the rtcuum dr.tn, methud of Hill nndDohhs 11J38Ygnve widely divrr¢iugresults. Detns wilh. • ('uCe and various M'drides:weream.ucaro•ssful. 84:6163fit A spcclroplrotumetdc method for Quantitativeenalysis of sugar mixtures containing known sugars. Lo. S,. M.; Garccau;,J. J.. (Eng. Dep., Univ: Quebec,. Three Riirers„ Que.). Cr,n. J. Chem. Eng. 1975, 53(5), 585-6 l11 Individual sugar concns. ranging from 255 to 1M7 ne/inl, tm specially prepd. ntists.. eontg. mnnnose (1)'[34iS-2S-J]nnd xvtose (11) [36-66-G]; urabinosr(fill [1J7-81'-9], glucose (IV)" and Fl,.and.1, 11, 111, and IV could he estd. with a mean abs. relative error of less than 1.5*7 , 14r,:•, and l0.^n,.resp., ' usingaspectrophotometrdc method baced.on anthmne-carbohcdrate ' reactions. The suggested metltod,required simple audiinexpensive '-anal. instruments; and less time to completee thee anal. with ': acceptable accuracy than for.chromatogr methods. , 84: 6078Jc No]yetitYli•uoblendi mieropnrousmoldings for filterinG: mnterials. Dnigo, l'ukitaka;. Cotu, Yur.uru; Nngno, 7.enji (SOmarMftp Ctr•, Lld.) Japnn. Kokai 7J,I:11,G65s.(CI. ' C05J, 13011))', 14! Nov 1975; APPI 71 511,U9~1, 02 Msv 1974; 5 pP. Pafyrthydrne (1)[9002-NP-1] (av. mnL wt. _>l0 X lOp)) powder is mixed wilh'an innrg. fnnming agent and a synthetic resin powder, filled in a mold, and sintrre+d nL ".5U° to give a microporous(pore size 5-]nU p), muldmg, usrful nsOltering materials. TLus,..I (d. 0:9J K/ml, nt.p: av. mnl..wt. Z!7A u' 104 '. w'nsrnixud with pulriinide pox•der (equnl mnt. tn 1) nnd.. 30"/e. (hnscd nn (he3nlal rr.ins) NHdI01Ut [IinGG-til-I)i filled in a moldl and sintered nlfur2.5 min, crndad„and releascd tngive: a micruporous (pore sire IUp) muldcdl pruduct with vnid'd cuntent J'.1Vo,. After the putt has ended, the 2 phases throughout the coal attain .. ouasithermal.c(luii. withinabout4 sec- . 60G 15 IOerl. 'I'he detn. nf the moisture '` 2urker 1975 28(11) , , rontentt of sucrose (1) [r7-50'-1] by the supan. of U1eUK~ '`,[SGS-33'-8] and EtOAc Ildl-78'-G] wah H'.O af f.rn.Me:SO and " pltiLt litlt: ur:orefd ngreement nenuurlcrn. gave re?n t (Within ' ' ;
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^ABSTRACI"S ABSTRACTS' i( -,ANALYTICALBIOCHEMISTRY ''J'anuary 1976 Vol. 70, no.1, p. 224 , ~ Analysis of Aftefnaria MetabDlites I vby High,-pressure Liquid Chromatography° ,;-i, IieavMSctrs......Y.......f e aa.....e -1c - -CS", OaircdSraresOrpanmenrufAgdi'uharc•Ajnr.hwalRrarmrhSrnicr;NorfA ' CrnlralReyae• lili Coffrlrr Avrnnr..Naaharraa• Kanras ddSOI ' ~ Reesired5/ay3.191AaccepedAugust20.19f5 A high.pressus.liquid chronutr,nphic. (HPLC) mdhnd is' descnbed for andysisofAfwrmrdametalpNreslnerainsurrhumandineulmnsoU/rernoriaan 7 graim.ThemeuEu[imrwerceamcredfmmlMsampkwithmmhanolinabkndan °" ... Ammoniumwlfamsnlutwnvu:rddrdm.ponionufthemeth.nnlexsraet.andtbe. ' l i - .«su r na.adyueous.aMse was paniunneJ.hrat wi1M1 hewne m.rtmove oil'and.piynwnts.ndlsenwilM1melhyknrMlwkNOeuruuhemelalolitrs.A'anvallsilka gelcMUmnraw,ualH'u.WUndeanenraatsfunher.xletabuliusweresepaated with Fonsil 11 ar LrrMa,-SIL eWumns fy eitherin.mmm-htrahydrofumn -' 1THF1 or Ixwlcum elhcr-THF. with solvrnr prneramrninr. and delecreed by= ' simullaneommnnimrinr of fluoreseenec and )]a.nm ausorbanee. quantiusiun M! ~ •Imnarinl moaumeshYl ethcr. alremanoli and Wenuene wu usually', based om ' fluore.cence: kn, than 100 ppb uf.each cnmpound snuld be dnected. Other r..mesabumesart.meminnedd!MieflY.. -. . ." .... . ...'••~ EFFECTS OF N-ACETOXY-2-ACETYLAMINO- FLUORENE'AND N-METHYL-N-NITRtr-N- NITROSOGUANIDIDE ON NUCLEAR DNA SYNTHESIS IN RAT'LIVER' CANCER RESEARCH -March 1976, . Vol. 36, p. 1'041-1048. Gai1 J. Guzzo & Robert I. Glazer A system for Ihestud9 of DNA synthesis in isolated nuclei ia oescribed for sham and regenerating rat9ive,c The system has been charaelersred wHhrespecl' to nuclearr purity, <on- dil/ons, tor optimum incorporation of' /5-merhylr'. ' 'Hlthymidinetriphospha'e. time courseof Incorpora5on• produet analysisAy neulral and alkahnea,snrosegradienlse and the effect of esogonou^.ly addBd.DNA. No difference m the basal level el'activnywasdelxled belweennucler pre- pared Irom normal or regeneratinginer when isolaled 24 hr a!lE0 Operation. However. exogenous:aallvated ~DNApreler-enlially stimulated 15-mPthyl-'Hlthymidme.lnpnosphale sn- Corrarahon in nuclei Imm regenerating hver, Activated DNA: - CausP.d to react with tbe carcmogen NOceloxy-2-aCatylaml-' rqlluorenewas a.less eflCctiwe pnmer-lemplatn in tnrs.sys- lem and decreasCE Ina dose-dependentlfashion the+nror•- porat/en ol' 15-merhyl•'Hhhymldine. Ir'phosphale1e. below, basal levels in nuclenlrom Bolh normal andIreg2neralsng'i nver:ThecarcinogenN-melnYhN'-nero-N-mtrosoguanioiner . had.no inhibitory effect when assayed in thO!fasman. VOL. 6, 140 e 6, MaRCH 19, 1976' . . . ... .. .. . n .,. ... NATUREI - . March 11, 1976 Vol. 260,.no. 5547 p.. 146 Isolalion of a subpopulation ofladhcrcnt pcritoneal cells Irith anti-ftpnlaur.tctivily W[ have relsorted Ihat.adliercnt pcritoneal eells.from,normal miccalimulalcsfnlsc grontharmaniymplsnmx:fn rfrro; while , adherent pcritomral cclls from miee iisjl•clediwnh Dacille -Caldlenclucrin f ISCCH were far less stimulaloepl The Ia11er . sure ocenlp eyrostmic when tested on L979cclls'n as well as on seseral other adherent librobla.succ mallgnanl'.t targets (un• . puhlishcdL lhis leads:us to:speculate rhat adherunt murinee raYilonealarlls consist nf al kost t¢n suhpnpulutions• one that' -" trndstontinmlaloandonelhac®ndsminhibittheprolifemtbn. . ormsc.•Iqihk• target cdls. According lo ahis sicw: infcetion or. the rnou,ce uilh IIC'G might kad to inersnscd numbersr. " eclisity of'the'cymsl:uic sullropnWliun at Ihee expeme of the a6mul:nnry wbP`pul:uion. Wee havonnu-isolaud an adhcrcnti . <stclasc-pmilivc, poody phaeocytir nwunnuckar perituneal " eell' wilh. Pnsent lumour.inhibitory capacity, which mayy represent tlsa penul:ned!cyloslatiesubpupulalion.. Cells wcm washcd front the umlimu6md pcriwncal cavilles ofD0.A/2orCDPISniceorirosnae_e-nsatchcdmicclauceks Nterinlrxlxrimncal i'nj[etion of lo' ciable:ItCG!ol'the Yhipps orPastcurslrains(Trudexu Nos f0;9or 101I1:.Thcallswere. _ waslydand'alloscedmadhcreloplulkJ5mmdislmsilialcnnf for 2-l h in RP?Illfdtlwilh 2g7;:fnclalialfs;rwo.TheJ6/tla. .,s'ere:themrinsed vi_rurously.in beaken of'sahnc, leaving cllswlsich ,srro cs.scntially all csscrasc pnsilidc'. Slartk granulasynTUfed frumlhc secds of Armrrnorlmvnarharr swre addedtofie monnlayers in eondilinns leuliilc to maa'rlsol nha}acyoie uptuAe, as:defined for Ihcse'ecll prcp:vasious.in pmliminary . experiments with "C-acet}I-I:d+clled yrunulas by r.wthods's described pres•iouslys'. Au the condusiom of the ptmgoc:'Iie period, tlse dishes were agaimavshcd vigorousfyy in sixbeaakers ofsaline. . . NATURE Feb. 26, 1976 Vol. 259, no. 5545, p., 671 Carcinogenic nitrosamides and cell cultures Tue au5lnitrn.amidlc clhylhitrosnurca (CNG1and'1 methyi. Oino,nurca fSfNUI'are Intlentcarcinogcnr in a variety of animals. Rats, especiallv, provide a useful eaperimental syssem since a sinele.dnse administered at the Rrinatal a5e Can IKtumnrigenic and in certain strains the nitmsamides mthcu;.eonditiimrare relativclpsile specificim:llat they produce a high proportiun, of neural.tumnurts-s...Although tbere IYinaun rarely.hccume cfinicauy aPparenl before.sie mnnths. Ihc .hort term effects of nitru•amidea have been fludied.hnth in rirrn nnd in rirn ih an attempt lo.elucidale Ihnnncugcnic mechonirnc Thns.hislnlogical.examihntion of Ii4su.•s frnm ral, rcccntly trcaled wilh nhrovmides has reseuledia toxic envcl on diridins cell,' while the use of ~ cell:rnllure, ha,ahuwn an effect on DNA synthtais and the O eesll cyclo`. It has been assumed Ihao In'th the earcin oo- genkstv and Ihe,,hnrt termeRects ocenr ar a rrsuls of the Q alkylainn of macrnmolecules, in parlicula,rDNA!: Earlier ~ rcpurl..enncemcd the nalure of the.e c 6 hcmically modified ~ uas"" whercas more recently Ilu lurnoser of such hases has hecume theincuc.of atlcntinn°'". We precent evidence ~ that thc ahon'.term dfectr.ean he explained hv,an aloer- N nalive mechanism to the' alkylalion nf cellular' macro- mnleculn; cYanale inn, are.shown lo bea Pnducrof SINU and ER(J hreakdown and it is the cyanale inn whichis rcsfsonsihle fur shnrt lermm eQeclsand: e9tulmticitf: . 1
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'ABSTRACTS ABSTR74CTS 84:53598sDirectsampleintroduction of high boiling -"eompounds onto, glasscapibinry colhmns. Comparisonn of :manYal'andautomatic sampling. Cramers, C. A.;, Vermeer,, E: A. (Dep. Instrum, Anal., Eindhoven Univ. Technol Eindhoven, Netha• Chromotogmphia 1975; 8(9); 479 81 '(Eng). 6'he performance of 2 systems for the direct.introductton high boiling compds. onto glass capillary columnsi for gas i t d f' l i l d f S H d nvest ga e cons e amp es s o .- romatogr are comparo e ` hydrocarbons andl steroids. The moving needle system, (a manuel version, Van don. llerg. P., bt: J., 1972) gives a relative std, deviatiomof'-2.5f9n. A Pye Auto.Solids injector modified _ for. capillhry gas chromatog. has a very large dead vol. since the "use.of sample holders prevents the direct.coupling:of this system to a capillary column. After introductiomof a sample holtler the ;, solid samplee evaps. slowly and thesamplee compds. ara apread throughout a large vol. of carrierr gas;, this badly effects theresoludan obtainable. To overcome this problem, the ovem of• thee ehromatographcontaina a capillary p'recolumm (--S0 em long) which, during a sliortperiod after sample.ihtroduchonl ts. lluring this cooling period, tFiee sample. '-tru-~?r cooled.by a flow ofair.l r , tompds: are effectively trapped in theprccolumn. After 1 min,,, the,cooling medium is turned off; the precolumn rap:dly heatsin, -, thee column ovenr and~~ a sharp reinjection of the sample: occurs.. ' - The repeatability'(end.is.better titan 1.5%:. There:is.no loss of - ' dl ` resolution Both systems are compatible with isothermaJan .e. . programmed.operation. In both'versionsh the solvent does not . ' enter the.capillary.column to mt appreciable extent', ... . . S _... .• Y,~rut ~ ~, ... • ses of ~84:.49303z Automatie gaschromatngruphiu analy hvdFocnrbons at atmosphcric concentrations Ncndt; J. G.: . -Fmgin, H.; Shikiya, J. M. (California Air Resnur. Board, .. Sacramento, Cxlift).. Cun/. 6frfhuds Air Po/luf Ind. Ifyg:9fud, ' PlennrySes.v:, 13th 1972I (Puh. 1973),.. No. 11, 13 pp. lEnpl. - Air lnd.. Hyg. Lab. CelifL State Dcp. Public. Health: Berkeley, Calif. A review with 2 refs. The theory, maintenance, and use of ' a 5-eumponent,automatir.gaschrumatngraph isdescribed. . . . HL L..Dilling 84i 53591j IIflgH-specd liquid chrontatography ofalkaloids. Verpoorte, R; Ssxndsen, A.. BaerBeim: (l7ep. Pharmacognosy, Univ. Leyden,. Leiden,. Neth.). Pharm. Weehbl:.. 4975~ 110(42),. 1021-37. (Eng). A review with 69 rcfa . .' 84: 42592j Increasing.the accuracy'of gas chromatographie. .. analysis by.computertechnolog,v,. Brovtsina N B.;'Simonov,. M. Yu: (Nauchno-Issled. lnsu. Eksp. Med., Lentngrad,. USSR): ' Kibern. Vychisl. Tekh: 1974, . 25,74'-9 (Russ). Acomputer. program was,prepd for calcn: of the areaof 2 overla,.-ping peaks, in gas chromatog. analii with precision >LS% for each off lhe. componcnts. - .~~ 84:53g10qGas chromatography. Elution tempcrature,. .. speed of analysis,.and separation, efficiency as influenced . by rate oftemperaturef prot;rantmingg andd carrier gas velocityy in open tubular glass capillary.columns.Jmmings, , W. G.; Adam, S. (Fed. Res. Cent. Nutr.,. Kar4<ruhe, Ger.);. Anal. Hiochem. 1975, G9pUi.61-9 (I.ng):. Thee elution ten:ps: and degree of sepn. of a.model system series of pnraffinhydrocarbons werefnllowed' as functivis of therote of lemp:. programming and carrier gas~velocity.. Gtaphs arepresented thaf. permit individual.assessment.of tliesevariables: Lower clutiomm temps. Can be achieved hyy raising the carrier gas velocity or- Imvering, thee rate of'temp: programming. In glasscatnll:rry eolumns of rtormal dimeniiuns(U25-mm,i.d: X 50 m); the tonmer is'nrueh.s less eltcctive and, resulmiu low•ercolumn efGciency.. The elution Imnp: of n-penlndecane varied fromi 139 to 309°and lhe. sepn. efficiency oPf the column decreased by 50% nstheprogrunt rate varied from I to 32°Jmin at n const. pressure drop. A.simpllt:'ird glass inlet.splitter and const, pressure-drop deviceisalso described• VOL. 6. Nor 6, MAR cH 19', 1976 84: 53G0Gt Gae-liqpid chromatography-mass spectroinetry of inetlrytated'nnd dbuteriometbylated per-O-acatylaldonon= ._r itrifcsfrom n-mnnnuse. Seymour. Fred It.: Plattner,J1onald ll.; Slndky Mure,v E: (NItRL, AR3. Peoria, 111.).Cnrbolfyrh. . r;Rea. 1975 44(2), 181'~ 98: (I:ngh'fhe peracelylated aldononitrilis ~`of thetetra-, tri~-, and dimelhyl ethers of ts-mnnnopyrmrose were sepd. by gas-liq' chrumntm;., and analyzed by'mass speclrometry. _' Through introduetiono of CUtO gronps,, various fragment-iuns eonstituttng tlte mass spectra were identified and rrlated to the parent'mrthylnted sug;ustruclures. Alsoideutificd were several ' -'ehamctenslic series of fragment ions that are common to 2 or •' "moremethylaled ormannupyranosides;. Ass expected,, mass spectra of.f the n-mannnse dcriva. were identicnl-tu those reviously nbsd. for n-glucoscmelhylatede in the snmcttositiuns. -,- P)is-tinctive mnss spectra were also recorded fur all addnl. •" di-O-methy4u-mnnnn>e derivs: This infnrmation.n permits use of peraceN•lated'..nldononitrile derivs: in tnethyluliom frngmcntaliun °annl: of nltluhexnns.. .~u. ..,... . . ..~. _„ . ...... . ... , .... , . 84t42094y Determination of sugars and sugaralcohols in foodsbygas chromatograplty:. hvata, Yuzu; Sasaki. Yoshiyuki; Origuchi, Kazunori;. Kojima: Akira (Nikken Chem. Co., , Oomiya, Japan). IL'ippon Shohuhin: Kogyo GaF.kcir5hi'. 1973, ~ 20(2), 60-5: (Japan).. Suitable.cwnditions of prepg. the test salns. . weree described furvarrous foods: biscuits, chuculate. siaamed beans, Japanese bean jam, jam, lactic acid berernge, dry milk, and caramel. Sugars and sugar alcs. were trimellvylsilated or ecetylated and sepd. by gas chromntog., using SE-nO or, QF-1, resp. Analyses weree made.for a-glncose. [50-99-7], tr/ructose ;, [57-48-7j, suuruse[57~-50-1], serbuulf50 70 1], mnitose [69-79-lJ„ mannieof (,69-65:-8] and maltifof [a85-8S:-6). Special attention was paid forr anal of thc sample contg. sucroae andmaltttol with good results. The internal std. was 2 et'hylhexyl adipate. Sucrose and lactose could not be:sepol by this method. . .. .. .. ... .. S:.Kawamura 84:'.53460r Application of a microvolume sample ilniectorto atomic-absnrptiou analyses. litglis,.A. S;; Nichnlls, P. W. (Div. Protein Chmn., Ctil[10,. Parkvilla, Aus[ ), bfihrocheni.. Acta 1975, 2(8-5), 553-9 (Eng). For metal.dctns..in 50:-500-N1i vols. by at; absorption spectrometrya sample-injectinn.valve was'coupled too the ncbulizer of a premixed lim,inar-llow, burner.. For' b00-NI samplesconlg. 1-10 ppnr Cu the overaill relative. std. devintion.was 1.7% for readings from the penk-heihW. facility of a digital readout unit. Ca (2-6 ppm) was detd. with an: overall relative std. deviation of 4,1°k in 100'pfd samples whenan -' air-C2Hz2 flamewns used. Cormectinga pen-recorder. to the reatlout unit and measuring the peak heights from the recordings. fmprovedlthe reproducibility and the lincarity uf response. Phus En SU-pl samples 1-10 ppm Cu w•as.detd..withan overall relative std. deviationoC4.3^6. . 84: 5359®t General proccdure for preparing high resblution gL•rsscapillarycolnnrns. Gorctti;.G. G.;. Liberli;.A.; Nota„G. (Ist: Chim,Anal., Univ. Rome,. Rome, Ilaly).. Chrnmatographia 1975, 8(9), 486-9(f (Ehg), llllth-resolution glass capillary columns for gas chronmtuK. arc precoated, with graphitized carbon black (GCB), The precoating is carried oul by flowing through the capillary a colloidal suspensiun obtained hyrxposing a 17 GC:13 soln. in' CI1:CIr to mrultra-.unicgmmratur. After introduction ofthef suspension intoo the cnpillary and evapn; of thesolvenl; a GCIlI layer is obtained which slronaly adheres to thesurface and iss m,t removed by washinit with polar and nnnpolar solvents. After' wnshingthe praphite surface, a new atatiimaryphase is coated on it. A great variety of coluams of different pul,vity ran lie: prepd. such as SP 1000, APiezon, Carbuwax; SE. 300 andSE 52, and their almraderistta.are cv:duatcd:'1'he use of a colloid:d snln. prt•pd. by ultrasonic means can he extended also to the prepn,..of gas snliili colurnns,.
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,84:.42099d Autrimated total protein nitrogen method. Walll '[.arey L.;, Gehrke,. Charles Ik. (Exp.. Stn... Univ. hlissoun Columbia, 11IoJ~. J: Assoc. Ojf. Anal• Cherrt., 1975. -58(6) protein N A rapid automated method for total n°). 1221-6 lF . . -[7727-E7-91 iasbeen develn]ied. using the Technit•on AutoAnalyzer f withhlockdigestor. NHx[7664-41-TJ is detd. by the automated ' NHlilif40l/h Af -rsacyale _reactun att a rate o: Sampesrn.no. o. .- ___ _ _._1aa n 7: was used as.a digesGon accelerator.. A salt-acid ratio.of 1:1 and a block temp.. of 425° were chosen. The catalysts evaluatedi l.included HgO, CuSOu,SeO+. and TiOz/ChSOa. Max. N in the ' "`shortest time (30mtn) was achievedw-ith.HgO' [I2653-71-31 as the eatalyst- The results from. multiple analyses of 100 exptl - samples of different refractorinesss with the block digestot method, using HgOorCuSOras a catal}st• compared well, wtth the results: bythe official AOAC Fleldaht methud.. The. -' accuracy,.precision, economy, and savin°of space offered by the -••Missouri-Techmcon blixkd(gestor method make this an attractive ~'alternativee to classical Kjeldahl anal. for large nos. of total ~ ! protein. detns: in samples of ddEerentt refractoriness.,The. : m•:A'utoAnalyzer cartridge manifold'issimple and'reproducible in v=?i its performance, end a largee diln., of the sampleis made on dialysis which eliminatess the matrixeffectsx from the sample •digests. At least'Li0,samples.can be analyzedd in:9 hr witl 1 tnstrumenlataonsetupr •r „ .. ....,Y . . - 84: 394149 Toxicolbgy of nitric oxide (singPe-lime effect of . ~ high concentralionx) Guguwti, V: S, (OSSIU: Vopr. Gigu•ny 1'7fuda! l•rnJenrmn•o.. 1974, 147d,0ntuss). From Rr/: Gh., KGim: 1975, Abstr. No. 171fi96. Title anl4 trau>latcd. . ,~ ,. .. :. . . . :~..::,. . ;. ; '. ."-r: ---.....,,..;......, . =-&1: 56U90C Rapid method for the deternrinntion of foliar ~nitrogcn Vaids, Pedru;: liudri;;uez: Carlos 1V:; Amural•. Arturn: (F,tc. Clena•.•, Univ. Habana: Hmana. Cuiia).. Cirncins,. --Sc•r• J' 1974, 117. l7'p'>7 lSpant. i•eal o-mnplea were digested iil HzSO4 and their N detd. by visual comparivm after nel:slerb.aliun: HI: 493J 9tu -Elintinatinp errorsfn chnnrituminescence nitrogen. ~'r•tidr.(NO,) ditcrmination in. aulomobile exhaust. Turner;. '-' Grurge S. (Iierkmm ht,rrum. hu F'tdlertorr. Calif.). SlF iTrrlnl'np.i 1971. 711(l.t•21,.i.pp. (LuK).991eprniblesources• • of error are.dtvvussed in the dcln. of NCl [101'.UL-43 9) and NOs'[IIa10'!-.11' OJ u] autunmliveexh:maI,.u(. tumltg thc enn.l. vol. ' -~s:nnplin•• li•st pruredure lhcdernl He (.ter. ao, (2281,22.15.5 (Nnv:. ..!S.1t/i15). ....._ ,..,..., ..i( r :.-.(:.A.iiurkhvd. 8-1:5Z7166~ Determi.natioaof~lotnl'soil nitrogen and orTanicc carbuti from certaii. infrared peal s off ir cur.esof soifs., Ali, Sharafat 5rn-astasn, P. C.; Sin h 0. P.:. De S: K. (Dep:. -' Chetn:, l/nn.. All.thabad, .Yllahabadlndia). J, ],tdiorc.CGcm.. Sot•. 1975, 52(0). 828-30Odng1. Fifty soil samplesfromditYerent regions of India have been collected and.their ir curves. ' were obsd. by iClLir-mull technique using [ erkin-Elmer Spect? -. rophotometcrq 137. The depth (1/~loi values of each it absnrptiom eak verecilyde and correlated with the values of.tolal'.soil N Pr 727-37-91~and C[71-IO a l'~0] .ep` Generally. Si OH tbonded and unbnndcd tvater-pe-ik) Si-OH (ibsarbed watcr-penk):Si-6~ (silica-peak);, Si-H (p11-pcak) and SirC (C-peak) belonging to' dilYtrent it regions bave been,found.to showtheir correlation, (both positivelc or ne^,atirely) with the values oC total soil N nnd ' C./tegressi,in (straight Iine) equationsweres also obtitincdd betweet the: I/lo values andthe N and C percent values,.wh{ch, _ may be used for routine anal...of.these 2 soil constituents. Vou r 6. iVo r 6,. MARCx 19, 1976 . . _..~.~ . }.. . ;xl 88: 57705x Formaldehydee titration ntethod for lhe dr•le= ,g. rmination oDamntoniacall nitrogen in phosphate gertilir.crs. An,aneyulu 1. S. It. (Coromandel 1 ert Ltd., Vwakh putuam, India). J. Aanuc. 0(/: AnaG f'htm. 075. 54(61. 1194 0(O:ngl.. : •-. . The present HCF1O tilrn.melhntl, applicable to NHr10iand . . I!NH4)zSOe samples, was.impruved fur. the anal. of amm mi.leal N. ..-[7727-37-9]1 in phnsphale Icrliliiers. Samples of 14-.ta-1 i' and 28.28-0fcrtilizerswere analyzed b,v the improved HCHOlhrn. methodiandaheresults were compared with the hleklahl distn: methodi The liCHOO methnd is nI!Plicahlo fnr 14-:15 14 and . c..~. f28 -28-0'fertilir.er samplea• provided the initial pFPof'the sample. -.adil. is adjusledllo PII 7.7 prior to Ihcaddn. uflreulyd F10II0. ;- rilit. For the anal. (ff samplesrnf plt rsphale ferullrers--ofIhe :• .salne-grade;e the iminuted I-IC1B0 ntethnd utlers a distinct. ,•1' •-, advantage over tllc hjcidahl methud and can be used fur the. ,. ., mpid anal. of nroamss control sample.,., . ° : 84: 57707a Determination of easily hydrul)reed nitrogen in soils. Rurubchenku:.Yu.'1'. (Nnin.hm I><Inl..tilant. Uwncn. Bulol, Sarnv, USSR). Aprrrk6imiyn 1975. (11d.11188 (t(usk A 5 g sieved soil sample wa> pLtredd in a 250~m1 Kj4ldahl.ll•ixk and 25 ml water was added. Then 78 drops ofmaeAine nil Ito prevent fuamiug), and 2.55 ml hON NaUll were added and the mixt. wass disld: into 100 nil 2"k boric acid. Thelatter was titrated.wilh.aniindicatar with lf.U^-.V'H_SO°. Fur peat hu, suils. only 2.g samples wereusedp and 5 ml IN NaOH uasadded. The results, correlatedl well with those uf'the Cornf(eldd mcthud [ur ! detg: easilyhydrolyzed.N [7727-37-9] in.suils• nowcommonly -84: A0371v Study and deaclnpnnenl.nf calalysls fnr remon•inq - nitrogen oxrdesns a, prrt'of reso(rta.c, trcycli.nl, technoloKy., Wnlanabc Shuji(Ustk(, h!uuic. Ir(h Itrs. In l Osaka. -fap:m). N.nnn Orubr A'rnxhu. 1975. 4!('1).. 121 r (.latlnnl. Ezpt.a. were carried oul.hr a Ilnww rr.dtod undcr conditions of, ' e.g;, space velucil,v' of 111.7n0J11W. hr (,: altlL pre..sure, 2111) LrFI° '~ catnlyst vol. of _1i:4 nrl: and feed gas rontK:8(1095t1 ppmSO ; 1100 ppm NO ft0t03-11 91,1"+k0pl!m ivi.6, 5?2' S1L '0 0, lo° . HeCI, and N Il•alnnccl (.dalkstsIrsted were mainly \i(,, .,j7~1a9-98-7]'-contR. catalysta.because nflheir high SO: reuist:mre:.. 1Jleir actisil.iesdid nut dearc•ue after 30 hr runs at.18t1fLppm. SO_. The amL nf.Nlh u eil was 52 the stuichinmetric amt. and that exhausted ti•ns 0 pptn. '17re rnncn. if NOz in theireatcd gas. . was 2fi.8pprn at 200°' and 0ppm at 3500. In the pxesence of Ol,. . the sclectivitg(if'the reaction was inrru.taed. 1'..Hayakaua 84:57.550t Nitrate and nitrite in hordicultural product.s: IV. Changes in fhe mtratc: contenb ofcelery during. storlge. H Ir.hkrmi '.Imamide• I:akuhisal O•ata. IQuti(asu(Unrv. Osaka Prefect., Sakm.lapna). Nippon ~~u1..uLm Go!!oi-Shr. 1973• v0('9421_5 (Japan). Green cclcrycontalned more nitratd in petioles than velluw, celery. Nitrate emrtent was lower.In the inner petinle than in the outer prdiules. Itwas higher in the upper petiules near dte firinodc and in Iltc butt than in Ihe.centere nll the pcu iles It unshighcr in the v,lscularr bundle than in parenchcmatous• tissue. Cclery was packed in perforated pnlyelhylene bags and'slored at l. fi,.andi 10°.. Nitrale content of Lhe petinlcs gradunlly decreased during. storage at each temp. The decrease was cnnsiderablc.., wlten the quality uf, ccelery was markedly lou•eredl No nitrite was deterted. duriitg slbraK& S. 1Wwalntlr:L 00009173
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~-x"--i 84: 42[g6e Relation af chemical constitucntsto the taste green tea liquors.. Nakagawa, Muui•y'uki; Ishima,. Nodo .-(Nad. lies. Inst. Tea, Kanava. Japan). Nippon Shokuhm t r'-. Kogyo G6kkoi-Shi'. 1973, 20(4), 119-25 (Japan). The liqunrs.of ' 1+: various green tea sampleswere.subjected to both chem•anal• and -'s•^^` sensual evaluations. Chem. constituents analyrzed weree tannin, eaffeine; sol. matter,. fTeeredUcinge su;aqcatechins. (epicatechin ~• ".'gallate,epicateehin.epigallocatechin gallate',and epigallocatnchin), '~id thiad g3ti amino acs (arginine, aspartic acid,canne,nuamc al't' acidh N, ppt: with EtOH,. and. Ravonols.. Thee correlation ~ betweenchem, constituents and:sensory evaluationwas dependent -",`, ^''on the kind of tea.samples and on thepanels,'Ghis correlation ~ foiid [5gOR2]l; ad tenin but twaspos:r amno acs, caffeine--n.n,, ' f 28 kidf dbtit It vras.neg:or sugar amongnsomesc:green.ea: was - pos. onlyfor t-arginine[7•1-79-3), but.was neg. fer tannin and catfeineamong 200 kiqds of green tea of domestic and foreign origins by the other group of.panels. Thus tha.relation.between ' htittdr quadratic rather . cem: consuens an palatability was moe: .~~than linean~ .The~ palatability was~~ more~'e affectedd by' the '; interaction of various constituents rather'than by any single one. ,.(;toi t„ I ,;J 5,. Kawamura i[, ~~: t f ^ t , i : " :e n, : Vdee ~ .. t ~,r,.,._. l.lr.~. ;' 84: 53932w Vasopressih release by nicotine. Site of'nclion• ''Bisset, G. W.;, Feldberg;W.; Guertzenstem, P G.; Itivh.r a Silva,.h1., Jr. (Dep. Pharmacol., St. Thomas's Hosp: h(cd. Sc,i:, ';`Iqndon , Engl.). Br. J. Pkarnmcnl. 1975„ 54(41 403-i4, (I•:ng). '-Injection'of nicotine(I) [54-11-51 (0.5-1 mg) into a laternl or hl l i h nra t c h.a•,: or 4h[rd cerebrall ventricle ofcats anesthetized w linjectionn of I(0.25.-2 mg) into the.subarachnuid space.llirou!:h the cistuaa nagua• or topical administration of I(b0 agY tn. the ventral surface of the brain stem produced a relensr of oasopressin [I1000 17-2] without oxy[onn [o0.5f,-6] iido _ '` venous blond.. 1 acted on the ventral surface of the brain stvm .: by activating systemsa•hich controlled the release of vasuprvssin •in response to changes in blood vol. or distribuliun: " •g•fi 573t7x Bouquet of beer. Konovalov, KL('Rolgarskue . Pivo", Bolgary, USSRI. Fermrnln. Spirt. Prum-st'• 1975, (8). 15-17' (Russ). A review w•ith.11 refs: of compds. responsible.for -'~ organolevtic properties of beer. taste. and odor threshold: in '- relation to tftem. structure, and synergism,. antagpnism, and inbibitiombelween the compds• in taste tests• °- - tDli5757f,f Retention of!volatile flavors inifood. 1. Flavor --r retentionin drit•& solutions of carbohl'dr:rtesSugiSawa• 14iroxhi; Aobas'aehi,.NnYiuyukit Sakngami, Akto. (La ma Univ.• K:q:awa• Jhpanl. Nippon Nhn/mhin AaRro (inkkni 9hr197:5. 2111H)•.:IG1 8 6lapanl. Volatile flavor [vnqrds. are ul'tcn retained in the dried carlwhy.Gntes in r'uantilics greater thnnrspeatc•d on the hasi.: nf v:qNU Irresvur eliaractvriaias. 'I'hc mmlvl s>•stcm anlsivtttl nl '1'rompnurrtts (or 1. wnh i•lwrruf [ di-Af-:rJ) uf w tti r, c vb, Mdrate tn ••11rrn.c [fill 91. r], m dh. r• sucrose. f~[vi~fun m [:19ti-117-i[ mnlturf,xfnn [!Ill.i/l tl I] (dcxlruxe " eqmv. ?ltL onguot nroaii• ['lOllll./ll .,jl, and or*, volatile - tsmipds. (I l hulcr:n. Ql/l.i-:il-J} \h(lll [br r0 1]{ 1•:(t11i1 .l Ir-5] I rlll.l[il' 't hJ. Itn()11 [rl 'HC-Y] or tWr'fiu(1l1 r4'1:11]I LhtroLrul/ ranlenl dlr.rlr.urdrvnl wt+dt4tl. Ity f•u rhrom ni,,. 'Fhe rvlrnliou.i I inl ddrs was mtlnt•nced byy a - no. uf fartr,r., iucludin,i the rcLuilr vuGdilitrof'v vacbh vulalili tYUUpd. md its.drffh.run tuvfl: Surrr n[5T'-511-1] ur mnlf-rnr -. -[69-70-4]1 colns-. rclained larger qu udntes nf'f roLUiles Ihnn the stdes, of pnly act h.lndt I ht vol u ilr s n t•iinrd wcre 9i .ta:i uf Ft bulyralc ,md 165 Nr oof d's% in Iln 4 unupo~tl' Ilt mtxt "I•6e obxl. vulalde rete•ulion. sh„wrd 1h.t the 4rctn:wba of micriliir ~ eolluid andlmirrore,^,iun fnr'entra'rpinA vnlalileswerc murl, rnure impurlantthun'thr• vynil. uf gas-liq, or ditlirsii,n cun.iJi•niii,m ut thevolatile• S:. Kunnntun vOLr 6, Nor s, MARCH ];9,. 1976 . .,..g4:42?39(' 3-Fory'l thiocsters In impnrt mrnlyaroma and taste. Kven. 1Yilbaun .I.; Hrmsnhn, Ilowardi II . 1r.: hlnyerx, H Pr nard-Prnard d.; KarolL Elirrberh A. (Inlt•rnnlir n.d Flavurc nnd ' Fragrances bu ) : U.S. :t,917,A6n (C1 I'ti fa7r. A.al.l• Ot Nov 1197.5, ApplIffir451• 07 Aug 197:1 19 Iqr. ('ontinunt:i.m in pnrt .. of U.S. d,tlrJ,7JG Flavoring agents of Lw fnrmula1 where K+'= 1. I 0. "scoa' i . ~.._.'~ ...-.~...1'. , xr. . ._....._. ~`R~J. . .- c , . . _ . t ' 1a'J , :.it ,.,,.alkyl or alkenyl or furyl, thienyh,tnlir~l, phenelhyl.or Ph andR: Ra = Itt = hie or H were prepd. 2•5-f)imrfhJ-:ft/iioacetyl . '. Juran. (11) [55704-22-2] (11, _It' FF, = Me end R+ = 11) was .; prepd. by n.lluxing 225 ml isoprupenyl acetate (I111' with 0.5 ml ..cnncd. 11eS0, and a soln nf 25g 3finoocctyf-Y•5-krvrnrdinne [5367U-5Y-3] ih. 25 nil lI'I. This snln• was adilydover 20 min and the refluxing continued for an addnl. 20 min. As the snln. eooledd to room temp•~ 10 gNaH(;(1:w•as added and. the Ill was removed in vacuo. Benzene (50 ml/ was added and themixt. -?::•) lransferred to asepg:a funnel. Waler (10 ml)', was added and ..iwhenC(T_evofution stopped the aq. Iayeraas.5[pd. I~he org. -r phase'was cuned. in vacuo'tn give 22.2 g nf a brnwnuil: this was distd. to give 11, ba:xs 47-48'.ll'hen lf was added toa.Ravor "--'formulation it imparted aa distincl rnnsl meat chcuacter and a .:: sliahtnultynnte.whtch.can.beassocdlwithroastnte.rrFravvt r' . ,' . r :. , - t .: 84•.575R'If Flavoring •16cnls. Rrnkrs, Peter• Tamclyna, )nzrf CGCCh 1 u,R54 ((,I A231), IS hi tv 1976 A]+pl. 1211/71, • 18 felr 1971; 3 pp. Compds.. twnl'g; aldrnse:puamdinc'ur urea and aminn.aeid residucx gicc (in thaating'wilhan aq. amino acid Rrdn, rnndensatiim products whicb imprnvrthe taste of meat and vt•gelables:. F: g, al.I:Sanixl5 nCkeratin Ipdrohaxde,A+lurncarFamidr .[24:N5-R7-5], and NaCI in aq. sulno was adlustcd~ to pH 5.5• relluxed 3 hr, evapd. at 00° an& drmd at.80°: 1'he product hnd the taste and-flavorof ruastedlmeat• L..1. Uclianrk . 84:421G0s Chemicat components and taste aft green 4ea. Nakagawa, Munevuki(Tea.Trchnol. Div., Natl. Rec: InsLL Tea, Japan). JNItQ. 1975.. 9(a). 156-60(Grgl. The taste of green . tea infusiom is cnnstiuued of 4tasle elements: bitterness (b), , astringency (n)', brothy taste (bt) and sweetness (s). A std. .. method of infusing tea for theseusory test consistedd of adding ... 180 nil hot Hs0'to 3 gg green tea leaves alluwiitc the infusion to stand for 55 min and then removing'g the residue. Takiin; this infusion concn.. as 1;L dilterentt conens., 4/9 tt+9i4 were~prepde and cnncns. 1 to 2f(f showed the highest palatabilityy and t6rs was highly correlated with 81' Addn. of lhcamne (J081-61G] caused an' increase ip bN and palanbility. Na, glutamate (L12-.17-21 and sucrose [;.7-:i0-1] tncreatt•dd bt and s with. a decrease in 6, a, and paLuahility: fea infusions were onalyzed byv liq, eitrumatng. un .xphadex G-ra: ai.d sepd• into. 5 ftacliuns and radt fraction was analyzed for snl. matter,. sul. N, ca/Jcine [5N-03-27• ammoacidAo tannin, and reducing sugars:. Recoveryy rates of sul. components were s90`Z„except forr tannin. It was detd. that bb and a were limited to fractions contg. tannin. prumipallycatechin [lif-23-4 andl7okofbtand>wrrefuund In fractions contgw ammn acids and redueing sugars, In nnn earher.expt: young.shoots harvested at 1st.pluckiug gave a better• tasting.lca than matutre roots and shuwed a highcarrefatinn with ' aminu ecids.andcaffriioe• Addnli.tests showed that the relation betwcen them. contpunentss and tastevaried• altbrmr,h a hiph- oatcchinh content always causes a hard taste and infusimr cuntlitrnns can detinitely affect the taste. •
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ABS1R6`-'!C9 J 84: 39869z Cytocbrome I/450associated with free polysomc : ; : i 7ractions. Craft, John A.; C"orper, Michael B',. Shcphnrd, Elizabeth A.; Rabin: Brian ft '(llep. Binchem . Univ. Call. •_Itrnulnn• London, hneli)'. F8/is'Lru• 1975 59(2); 225-9 (EngfThe content of,cytpchroqle•P45U (1) in, the-free pnl'vsome .`liver'x rs studrtd'todetd if thepresence of I was fmctinn of rat ._ . ; d rOntaminatlnn' (1ym4ntlVdne'.. ElettrOn mrcroi,cr)py of the L Ue n ~-freepnlysnme fracliiuni demunstrated' the presence of huth lpi cnet hn ru ~ srae vKc.e Tcpopn but tht•.. pre+enceof I w+..elenriy - . lhis fractian was Inw , ,:,;,demonslrated- Thespeerfrc cnntentul' I (exVrc.w:diin termsnf nrallcled n li f ' rios mr o p I fuund in the free IMoIvsomc +. ph(a.pbulijnd PI flrhnharhilal h ntoninh mmrn ~ t_.It 91re lower Icw 1 hf'mtmhr:mr1 + in n,ulruls atment as x•ell n . . e f_..vdihalnimls wrurtfh•cled in a . uwt i¢emae)p. '/(m•ecI enntcnl.in the frtc po(1'sume, frarliunl I'he runla•ntcof retaf mirnrwnnul rniHnrs in thix.freoisd,vs,)m(• frurti(mcwhen ~lxprrssrvil in lorms of ph,Mplr.dip.d wt rt , snniGir nr lhusee fnund bj t l - cr eK hb fliWhu Inr puIvsnnu~. xrve su in lo.m/mr.urcraruns.c ' u-h-Adioni much nf the Incmbnumus 'to a'Lnd bunvmit d: cenlril enntnmination wnseliminated, yiekling a polvsnme frnctiun' in ~' whii•h Iaudd'.nut lie deteclyd. 1!tollttrlnarV resrllla.with rabbit ' ba-o -liverr prepns. were similar. Thus, I fuund in,thefree fxdvsume .,,. na"~ fractiuns is Prubablyy ncrur•d. wrth mrmbr umusrnnt )mmatron. . _. . .__ . . .t. . .. ~ . . / o.,I~ -~a 39a33k Effect,of chrysotile-asbesios.dust on benzo[a= .' )nyrene tnduced caretnogenesrs's im rat lungs. SuLk,R:; Vosamae A(UStiR) Yrnfrseional'nvi Rah 1974. 51-5. (Russ). -]+rom Re/ Zh., Khrm 497a Abstr: No. 171620. Title only ;.translated.... .. ,,.,.. .. . ' - .i:?r.:. .. . ' 83: 55131h Seleclivityof ar,vl hydrocarbon hydroxylase induction after3'-methalcltolanthrane pretrcatment5 Klceberg;. '.U.; Barth, A.; Rot(i d;: Klinpcr.lV•l:arge, E. (Inst..Pharmac•o6.Toxicol.•, brmdrich-Schdl r Univ., Jena, E. Ger:).. " Ada Gro1, Med.. Ger. 1975,. 3S(10):.1701-5 (Eng). 3-Mefhyfb A lecture on gas chromato.., particularly its principles, detectors, column packings, samp!epretreatment, and.quantd anal. -- . A. Matukuma - Tokyo, Japan). Taisha 1974, P1(5), 1151-61 (Japan). _ .84:.55995t Fundamental aperation of instruments; IV. Gas chromatograpkl 6liyazala Hiroshi (N'ippon Kayaku Co., l eholanflrrenr (1) [50-49 51 Injeclad i.p. into rats (L,1f), or IOOl mB/kg) causedthi,~,hlt .cloctive.lnductiort of aryl hvdrocarbomn hy(irnaylacc (EC )l7 1-f1) J901r.S0-u7 in the liver, thee ihdurlion effert being greater m)d la tinglunger as the dose wass increaced. Similar re.uits x•ere.ub d in the kiiirey: '1•Ite: other , biuchem. parameters studied (.urcuoate'd:h;~~drn.eenase (ECf.3!+9•]) (!)0u'!.0! '.1 and glucu..e Gf,hnsphntuse ('EC 3.L3.9); [9001-39-3 1 were nnt influenced by' I, nnt wore any morphul., allcrntinnx,n the livar nb.d. rwsn afA the higliest conalrs,of L..1 77here!ore;.the 1•-mediatedaryl hydnxarbnnihydtuxyfi)se indurlian is npparenl'ly a..suitnhle rnouel for thcexanme of dosedependont' inducer-inhihitarinteractions inn the.intact.animal. , VaLr' 6, 140, 6, MARCH I'9, 1976 ""g4:33506sEvaluntion of.the aclivil ofdru g enzymes by various in vivo paramctcrs. HilUebrandl, Az1G.p ' Rootv L; Sperk,.M. pnst'. IJin. Pharmacol., Freie Univ. Berlin, Berlibl. Ger.).. Guzz: Sanit., 1975, 46(3-5), 73-8 (ital). ~~ZU l 5 i r rt ' e,, -0 rn o t ~ Oral administration of 300 mg phenobarbital Q) [50-06-G]/day' for 14 days to healthy mem increased theurihary ercretion of - 69-hydroxycortisoI ando-glucaric ncid, decreased the plasma Iralf-lifeofaminnpyrihe after amoral dose: andihcreased plasma ., Y-glutamyl, transpepl.idaseactivity, all indicating induction of;: microsomal!dkug-metabolizing enzymes. Theretvas a signiGcant .. r~~!u: correlation between theeffects oG I on o-glucaric acid excretiom .er and aminopyrinehalf-life. Each of the. 4 tests however, ie. •.,: considered to be individually of diagnositc value im evalirating: - ;:t induction of mierosomal enzymes. Administration of clemastine. • i :I5686-51-8], on thee other handi failed tocause enzyme. induction, aajudged brthe above paramerers. The description, . of this work is preceded by^ a discussion of theIrmitatfons of r methods'.designed to prcdict:drua'.me69bt ratesin humans•.esp. [ ~ ~ f 450 - with respectt to~ detn. o( cytoc:ome~ F~ in liver biapay' -. samnles. ~ , . .. . . ' 84: 5720?v in4talation.ancsthetres. andcytochromo P 450 '. deper.dentt rcactior.ss in rat liver microsnmes Ilnlothan e .. '. and hepa.tic microsonral P 450. Commcnts: Hevnolils, .. ' Edward S, (Pcir,r&ent Brigham iiasp., Buston, hfass.):. Anexthesmlogy 1975,. 43(6).697 ' (1-:ngI. A polemlc. In eontcnst to tlle resulLs nled bc Hallen and Jn mvnn(1bid; 197,5, 43i 3440), there were striking decreases in liver mirrosomd evtuchrume . P d90 [901r il-2) cuntentc immodrnrlv and. 2 hr aftera 5-hr Ihhnlal.iun uf' 0.85% halothanc Ilal 6,.-7j in rats pretrcated with a pctent inducer of the mixed fanction oxidnse system, Aroclur 1954 (1511ymolex bygavaGe lur • duysl:. . . 84: 53772u' Mechanism of induction of hepatic microsomnl . drug-metabnlizingcnzymesg by a, series ofbarbiturates: loamrides, Costas; Parke; Dennis V: (Dep. Hiochem., Univ, Surrevi. Guildford, Engl.). J. Phnrm. Pharmacot. 1975, 27(10), 739-46 (Eng). Of 6 barbiturates tested those with low rates of 0 1.a•Pn,Fe•Er , n • a•CHMeCH}Me .,a1rEr. 111. a•a" OHrCH:CH2 metab., andd long, plasmn: half-lives (e-g. Phcnnbnrbitnne (1) 150-06-61 and pentubnrbitone (II) (i7-33-0]). x•ere the most pntent inducers nf hepatic microsoma( drut-metabnlizing enzymes. The most Lrotent barbiturates interacted with c}fodlromeP45Q 90..5-51?J. su6gesti, that they actt hy strbstratee induction. urbitur•ues contg. an allvl group.. e.6• affobnrbirone(111) u3 43-7), had a x•eaker rndirciirg eltect than espected• possiblyecause thexdertroy rvtochrome 1 a,i11. '1'he relutit•ely highpntency of LhiopentorlP [71~73-81 (h•rll-life 0.3 hr) was prohnhly due to its metnh. to 11 /half-IifeI.Albr). 1lorbilnnc (57-44-3jdidnotraixc)tochnm1e1M5t1'.Ievelsbut,induceddmg-melaholizing1 en2ymcs tau similar extent as I,.prubably because it incrensedNADI'Cd. cytochromec reductase activity'and cytochrome bat levels. • QQQ09179.
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-r,;, :.&L'578?f,n Uptake and removal of ni~trogen,. phosphorus, ,~ and; polassium by'tobacco plants delrending: on snil fiertility - and npplrcation o0 complex fertilizers. %mnanuv,. 1'. li. IlS.SIt). 7r .4:erh: Fd brs, fd-rn. f'urlu•nordue 1971, . 121 4 -r c r_IliuYa. Edited hy 6uumov, I1:.61: li.d. 'Elm': Baku,. USSR. ,.. For lu/Klh•of Ilky kg tech. m:LLure tul•acrw Iraves, tuhactvrplanta Kruwn un nn alluvinl. muul ,w;. sirnm•mcalranvms ,u,ill utiliivd murc•. N, P, amli K: xhur eumplea' fertilizcrs than when aingle fertilixern.werenppliivl Phe highla N; I', and Kuptake liy ~Johaccn on Ihatt s,il'l type was, ohsrl: when nitruammuphoska- rt1. l,F ' ..' 1{'J - ry:-'84:.39117aEffecf of orane and suifur dioxrde: singly and '"ilminophnska, and diauunnnitruphaska terliluers wrrc aPl'lit•u• uoncdnarenus meadow fnrest WIl&. thl•e iu,Che.Gt rurlnenl r°O n '.1 anvmld:rLnn by', tuhatt n pl mtc nvv. rdrut when KN(1,. amrnuplnnk,u K ' ranteut I ° and diammnnun,phosk r tertihrx•rs were applied.he q°of tnbacco was hlghl^d whenn nitrnirh rka. nitnwummophu.ka, 'tKNOS. ammaphuska, and diammnmtrnph/iska fertilizers were ~ • ~ a. tV,s ~ . ''~ . ~ applied. I •' r In combination on.pfant grow•th. Imt,ey'. Uavtd 0.; Rernert, • rot. Agency, Richard A. (Natl. Ecol. lmh Fitsirun. 1 . Con'allis„ Oreg,h Errorrnn.. Puf/nt 1975, 91^-), 117-2•5' IEnpt'. ,.rq. i:/'lants were exposed to Oa [10u2ri 1, 6] and SOe [74J6-09-51 nnglyor incnmbinatiun to examine: the efft•ctsuf gasmixtss on .' plant growth. Chronic expsuresuf inbaero (Nirotinnc tabacum) ^, to these mixts. resulted in gww•tfi retins. fmm the mix treatment. ;;;equal to the additive effect af the siu•le gases. Chruniu. . exposures of alfalfa (A'fedrragu snlirust resubed in growtA redns.. „ frum' the mixed treatment' that were less than the adtiitive. -~-effectss of the single gases. Jingle acute expusuress of radish. •' (Rophanus.satii!us) toOs and(urd SUsresulted in growth.h eedns. in thee mix. treatment no different frumm theeffectsof the. . individual gases. None of the gasmixtss caused'a greater growthh redn. than would be expected from the additive effectss of the single gases. This is.in,eontrast u•ith foliar injury, where gasg mixts. frequently cause more foliar injury than lhe sum of the. _ individual pallutants - . - . . _ _ . „ , . 84: 46944bTreating smoking materials. Mergens. William Jy Newmark, Harold L. (Hnffmann-LaRoche, F., und. Co., A.-G.l Ger. Offen. 2b506,100~ (Cl. A24B); 21 Aug 1925, US ' AppL 442;99Q, 15 Fe 1974: 166 pp.. Equimolar mixts. of' , ascorbic or erythmbic.acid with..their corresponding salts (such. . as Na):were added totubacco to lower the NOr and.nitrosaminecontenrs of the. smoke. The addm was e:g. aspnwder or aq. - sotn., at 1-4' % by wf. of tobacco. Thus, the addn. of 12: mg off an equimolar ascorbic acid-Naa.ceorbatpmixt..to.the tobacco contained in 1 cigarct, decreased the N02 content of the smoke by 42-62%~ . W. A. Peabody ~84:'40865b Productron~ ofP.NA and coat protein of a . wild-type isolate and a temperaturc-sensitive mutant of eowpea chl!orotic mottle.vinls in eowpea leaves and tobacco protoplasts. Oawson, J. IL 0:; Mutoyoshi,. F; Watt3;, J. W.; .~ Bancroft J. B: (Johrn. ]nnes Inst., Colney Lane,Norwich, E11904 . d: Ocn. llrroi• 1975,. 29,. Pt. 1,.. 99~-107 (Eng). -' Tke . multiplication of a temp -sensitive(ts) mtuant.t of cowpea . ehlurulic mottle virus(CCSiV) I in tobacco. protoplrsta has been exemd, The resultsweres similar to those obtained'd with intacG cowpen plants.. No intact virus was producedd above 33:5°', and • ao coat protein;.eithersol• or insol., was detected in lhe.absence - af inlact virus, ItNA of the tsmutant, however, was synthesized at 35". Virus particles made at 25° were degraded in vivo when tke infected prutoplasts weresuhsequentlycultured at 35°• RNA~of ts CL•JIV was appnrently enca•es•Jatrd'~& much moree often than ItNA-.e of'wild:-ype.(wtl CCAI~' in doubly infected. protonlasts cultured at either 25 or 35'. VoLr' 6, iVo r 6, MARu 19, 1976 .'a,.. .. . .. ~ . "~ 84: 56585w. Nitrogen mctabolism in plunfce1lt suspension r~ cultures. 1. Effect of aminu ccidv on grnwth: lif•hrr•nd. r~ Jur:ef{ Matelec, Richard 1.. lHadass,lh \bvl.tich.• 19i•hrew Univ., •-•Jerusalem,.Israel). klantl'hysinf. 1975, fAi15! 584 9 (Engl. -'~r i;~ Certain nmihn acids inhibited growth nf whauo. (vicremna i`tabacum), tomato (Gycnprrsicnn r.rrufentum) carrot (flnrnvs rarolh): and soybean (Glycirrr mox) cell culturrs when NO., or -urea were the N sources liut not when NIh•is the N xrmrt•e. -'~-Tkese aminn acids also) inhihileddcvclopmcntd of uitrnte~ ?'reducWsc activity (1iC LIi.6.l). in lobaccu.:mdtonmto culturrs. ••Threonine, the most inhibitury mnim, acid, also inhibited NO:, '~uptakq in tnbacco rell.. Arl:inine, and u,mrl other amino nci<is, nbnlished the inhibitron /dterJs caused hy olher nminno acids. t' ;'71hus, amiiw acids inhrbnt n.imilnuun uf inlran.lhdar NH.• into ammn aads in cells gruwn on NO:r or urt•t ' :;, ; .. .: t,,.y~;: . . .•%f ..i.. .. "84:54728w OcuteriumisotopecffectsinNicotianatabacum. Can J Bot. (Chem. UtvhsuArgonne tNatl. Lab c, Argonne, ; IK~ tz,c '0 `'53(19), 21'28-A3' (Ehg). Growth ofN. tabacumj?inntsin the ' `presence of 70% deuterium oride. [7789-20-0f resul3ed in- '/" ~`eomrolete inhibitinnuf flowerir.^:and decrease of the tenninal wt. .'.rof pjants tm7.5% of.control. Extensive lunf necrosis was.ubsds at • lhe higher a11i0 conens. The heavy water treatment also decreased the ninotine[54-I1i-5] content of the leaves, increased transpiration rates,. and decreased fractionation of C tsntupesrn.phutosynthriv. 84:58G58w 2 hiclhvl 4-pentenoic acid ester fragrance.' . Hall, John B.; Tseng Ching 1'.; Vock. Manfred. H.; Vinals, '. Joaquin; Shuster, Y.duard J. (lnte•national Flavors and Fiagrances Inc-) U.& 3907,718. (Cl 2u2-522;.A61K), 23 Sep 1975, Appl. 490;718, 22 Ju1i197a; 12 pp. Alivale:.reacted with EtC(OEt)s and H3P0, to give. CH I.HCI{:CH\1eC0:Et (1) hi h w c was transesterified to CH::CH[,HeC111feC0 R(11:, R. _ CH!Cl{t\lez, hexyU; I andi ft demonstratedd e•tectivcness as flavoring additives for food andi tobacco and as cosmetic ' additives in soaps and:perfumes.. _ . "84:42071pPesticidc residues in food ofplant origirr:. Bressau, G.. Qr\•laxVon Pettenknfer-Insl., Bundesgesundheitsamt. : Berlin, Ger.). Mrtt: BmL ltuadesanst.. Land- Porstwirtsch.,. ~~Berlin-fJah?em 1975. 165;82-94 (Ger). Arcviewwith36refs: -" on the. occurrence of insecticideresidues in tobacco-o and plant-derived foods, andd international legislation concerning therr restriction.. 84: SGG50y Analysis.ortlle.monopuenolic.lYaction of-tobacco, smoke eor densates by a conr4,in•ttion of chromatographic metlwds. Malaterre. \t , Lohoac, J Sellicr, N.; Guiuehon, G: (Lnb. Chim. Annl. Phys, Ec. pulylech.,, P'alniseau, Fr:F. Chromatrrgrnpltia1975 6(11),.621-8 Ibr). Mmmphenulswere isolated fram tobacco srnnke condensates by thin-lLyerchrematngr on I(ieselgeLG using a.3:1 mlxt. of cycluhexane and 1it0Ac. The monophenulic Bactinn w•ass recuveredfrum the support and analyred, hy. gas chrunwtug. on a capolary column. 'I'he yield was 80 % for3,4,5-trimethylphcnnl and 657fur 2:9.5-trimcthy9F>henol. The cnnan. detd. fur phennl..(p+m) cresld and 2,6-dimetf:vlplienul were 6:0, 3.0, and0:5I pg/mg nf condensate rasp. Numerous ather alkyi phenuls were identiRed: . - 00009161
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SOUTHEASTERN. SECTION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH - ..;, , .-.... ..,;e . .:.> . ~~.. , The Southeastern Section of the American Assouatmn for Cancen Research ;(SECRA( will meetbn October 7 end a 1976 at the SheraloroB II H ~ mor t l + ri e o e in Allanla, i'Georgia. The.mae0ng wilPencompass Dlenary sessions with scientific presentetrons ; bymembersand3workshops.•'MembraneASceptors:""Regulationof.^.eneESpres- F sion,"~and "Chemloal Carcinogenesis.l'ForturtherinroFinauon, cantect tde Program Chairman, Dr: Edward Bresnick. Cnairman oLNe Department of Cellularand Mulecu far8lalogy, Medical College of Ceorgia, Augusta, Georgia 30902 r~. ._: .f .. . . .. . ~t - PERSONNEL LS I 11 • - J~.Ln, . ..<A.;.c I Ltirilldrd has restructured andircaligned~responsibil- - . nimponsits Advertising and Brand ManagemenCDc- . .. partment:. ..CharlesIV. Toli has becnpromoted totlienew position of Director of Marketing Scrvices,M with rn- .. sponsibilities including coordinating all cigarette brand media, promotion and research activitics,man: .. aging.allcigars.and chewing tobaccos, and directing . - . special eorporate projects, ' P. Ron.. Cutronec ha.becn- promoted to Group Brand Munager, responsible for thesnpurvision of both~Max.and L.-T:,Browocigarelte.brands. I . . GeorgeTelford Itiaslecn promoted to BI'andMon- .ager-True. ...... v ~:,:., ..-. .~-:. ..::~,... • OMher brand assignments include Valerie Fried- -, rrrmr, Senior Brand Manager-KenC. Joseph Gior-`' ' dano, Brand Managcr-NCwport: RnsmllCnyclle,.`- .- Brand Manager-L. T. Brown;: VValler. L-mcaster, - Brand Manager-Old Gol'dand Zack: Sam ttidgnay, - Brandbtanager-Max: `.I . .:-:-.,:•.... . . .. ..,. VoLr 6, ' NOr 6 MAncM 19 1976 , . LITERATURE SEARCHES LS# 55 FATE OF NICOTINE IN BODY LS# 155 - , ; . , . -. ,NICOTINE; ADDITION TO~ TOBACCO, USES, SOURCES -PATENTS, SYNTHESIS . ti -328 S
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ABSTRACTS ; PESTICIDES ABSTRACTS Nov. 197'5, Vol. 8, no. 11 ~y 75.2179- Lench. R. E-; Pease: H. L. (E: 1:.du Pom de Nemounand Co.. Wilmington. DE). Lannale-mehom)/. D1'r Anulyriral merh'ndn/w prsricidesand planrRwn'rh regulnlon. Vuf. Vf!- ThinJnyer and N9eiJ e'hrunrusnp: rophy rrnd unafyses of praridJes q:intrrnaAnnul impsr• ,'.s tbncr. J. Shermnand G. Zweig. FAs:. Academic Piess,. . -New•'York. 1973..p.331'.338.1.3referroces) . `- Lannale: toxic to imects both by direcl contact and ,;ittgestiunI is pmtrtuladyy useful in commercial plants of aweel curn. tomarucs- p-xaluh. eabb:rge. cauli0us.er.. bnxenli. headlettuced and tobacco. The acute nal luxicity. .: LD!0 for the male rat is17 mg'kg; female.rat. 24 mtckg. d^. Lannalemelhumyl insecticuieiscommerciallyavuilaFle in Ilrr United States, as a water-ssdublee prrwder comaining ;: 90'A aclivc ingredicn[. The.in.eauule is also prepared. for . i:.foreignmarke/s.asaa%Em1uMe.puwrlerandu!!mwe11+ 'a:yble IVwd.-rr for appficaliun in wa[er sPrays: F'ur frmrula- _ :- 4un analy.ir9he sampk.is diluled with talrahydtnfuran , Jnd ancdyzed.byliyuidchromasugmphy+ ucing an ul- •• 4aviotet absurptinn delictur. Elaclrunir'ilrlcgrmion is 'I . psed7omcasura• peak arua. Acatanilide is used as an inter- _ nal scandard- For rexidue aoalysis melhumyl msidlms are,e dcxcrmincd by Ihe.gas chrunsulugraphic mca.urcvwnt of the volzlile. mure stable hydroxamle: methyl-N- hydroxylhiweelimidate. Sfethumyl is eatracnJ from the subslmte by an organic sdvent anJ'suhse9lscnt alkaline hydruly.ix yiclds the hyJroaamate- Intermediate xnlvent/ panilinning cleannpsmps are needed to minimize possible rnlerferingcompuunds. 76-2g0S. Zweig.G.lSherma.J.(LifeSii. Div..:5y'racurp Univ: Res. Corp.. Syracuw: NYI. Pynethrins./-9: Annlrfil eaf inelrlrnJs fen prstirides, unJ phmFgr'u•'sh, reXUfrrt.rrr. VrJ.I'h GasrbrnnrumRwplrirenul,rsia. G, Zweigand Ji. Sherma: Eds.- Academic Prrss. New York.19T-f p. <61-., a70.113 references) ' ~ Methods are.recommended forihe formulatiumamf residue analysis od'pYrelhnns. The acliveinCrcJienb imeommercial mixtures of pyr<thrins-.pipemnyl butuxidc . fPBO1: and mmtylbicyduhcp:ene diorhoximide tNOB DI') are measured simuhaneously by gas chmmatokraphy after eleanupon FloJsil[oremovenil-basNmateriulsandn[her w6slaneesthal would.olherwise.interfere wiM thre analysis up,the NOHU compuncnl oflhe feumulatiun. A. - Varian Aerograph'.Series I200'chromalugraph equipped with a 0ame iunization detectnr was used w'itbtwo"k %. • a.gin:spiralborosilicategkrssedumnscontaining34&and . !!T SE-30 silicunr. rcspectivdy-coated onChrumusorbW. With tkism<thods individual penicide components presenl in amounts ranging from.0.05-!dlnxan be.mea- sureJ accurately. Pyrelhnn residues are extracled from meat and lissue samples with permleum elher and frofn milk wi[h elhes-pr[roleumetherm after which the exlractss are panilioned belween aeetonitdlc and petroleum ether m remove much of the axtracmdlfat. Chromatography ahrou:hFlmisil separates the pyrtlhrim~fmm chlorinaled pesticides and final cleanup is.bynhto-laycrchrummog. raphy Wilh delerminatinn by deelron capture gar ehromaingraphy on a IIA Xt ih: eolumnparked wilh17e QF-f pl4s 1^rc. Epun IOOt.on.Acropaka301.76g0.mcJi:. Recovenes in milkmnged from 30`7c at the 0.0]'ppm level 1oRAkat the 0.1 ppm levell senshivity is 0.05ppmon a wbolle-mJk basis. - 7S2gAk Leary.l. B. (Chevron Chem: Co., Richmond. CA). O[Ihene. JN: Anufyffcul mrrhndr f ir pesf:rider.and . plrMrgrnnth.regufhmrz.Vnl.VfJ:Tliin-feyrrandfi9uid ' a•hwmnrngrnphy und onnfysrr v./ prreiriJra rrJ inrrrnc.. rlonuf.l impuqnarv J. Sherma and G. Zweig, Eds.. Academic Prrss-New YorkJ973. rr. t63-169. ss l.r.r....s ' Wrlhene: an mganophosphoms compound with re- - i s dual systamatie activit iRNihid y:seecve aganst apS sev.. , '. eral spe'cies nr armyworms:,bagw'orms. cabbage looper... . diemundhacMmmh: impnned tahbageuronn, .bdlwurm., . lace hugs. leef minera lygus bugs.leulhnppea; eutworms s - thrips. and Oluh. rfra. Acule oral_LDyO of Iechnical.Or-., km:Ja.Aculeoml!LDSU7Urmice.is3o1'mg'kg.Forfor- _.mulationanalysislhesamnleisextracred'urdBundwirA- . .r ...,5.'. ne: yanoaru smuunn In melh)'lene chlonde and _ anelyzcdhygaschromaingraPhy.usingathcrmalcnnduc- _ , -[4il i t wry detca Rmidf Ohd ibli ocucx onene anlsmemole 01 -. ORTHO9u0Rareextracledw'ilhethylaretateandinterrer-._.. :~': r... ............._ ___ . .. . , -__.. . _...._ .....-_.`-- . ~ selumn. The reaiiluoismeasurcd by.progmmmedrempera- ~ - ' furt GCusing a th<rminnic Jeleaor. . , .,, .. „ ,. 7547A9, Zweig-G:; Sherma.l.lLifeSci. Div:. Symcuse. Univ. Res. Corp..,Syracuse. NY). DJ'lox. JNr Analitirnl mrrhodsfiu pr:ni<'iJ~r aad pfunr gron ih regrdufurr. Vrd, Vt. Gu.o'cbrr.nruf..prnpdir nnnlyais. G. Zweig and J. Shrrma- EJs„ Academic Press..Nlw York. 1972, p. 387- 392. (g rnferenceq. - Prncedures for the formulation andaesiJue analysis, ofdYlnx (vichlnrfonl urc dcscribedi Dylox powJer furmu- Itlion is extracted with ethyl acctme and analyzed by gas, ehroma/ography onas N 4 mm i'J. Pyrex glass column Parcked.uith 25% Carbowas.i0lf~on 80 90 mesh Anakron ADS. The method iseensitlve tug.01 ygunda precisionof Ilxe' hasbeen oblained fonseveral commereial furmula-. tions. Dylus residuesare eafrncled frum alfalfa wilh sul- fur'u• acid. subjected.to wuter-e[her partilion. and deter- mihcd hyy thermionic'. flame ionization gas,chrumamg- ruphY. The 6 fl k ItC in. Msronilicale glass cnlumn is packed: . with 16% xF-1190' on 50-A0 mesh ac.itl-washed Chromosurh W-Thesensilivity nflhe methud is ahout 0,02 ppm:mdRecnveries range frnm 79:RO7 Inn0.1 ppm Dyb% and.frum 10]-IUSSg for. C.S ppm Uylnx: Nonc nf 49 regie- aered phnspAnruspeslicidcsinterfercd with Ihe.procedure. For the analysiiof Dylox in toils-Ihe residue isearaeled with ch7orofurm. concenlrated. and injeeled inlothe ch'fumatugraph.wi0mul cleannp. CnOOnseed samples are EMnded with cblursdurm andlheDylox isextracled from Skelly sulve B with water. The pevicidc isthen panitioned inla=chlorofnrm. thcsulvcnteraporatcd, and a portion iNecti•d linm Ihc gas chmmatogreph-
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W, M tr uro EWS •BRIEF C& e,aaf..p nt 4~`r a'y ~ 4-.e . tE NIWS',~r , Jar, ., F`eb. `23, "1976 IvVol 54, 'ho 1 8 ~ ~ a; ? Health hazard alert for chetrlicals eyed c~ p~j-e F[c '~• . ' M theitst of suspected chemtcal.~ urunogen< tn thewrork place ~} ~ 1 grows-. sn dt~es lhe need It ,1.eep awrkerx-and employers abreast of a a,1he iatest ,nfurmatiun.on the safety': _ ~ - uf the ehe•ruea,s,they wtrk with. ~3-Y~Jdeea'. nn how to _ g i abnut tlas were `}y, plentiful le t w•eek et.the first pub,~ W[ meermg of .the Latu nal Re-~ ~.. ~tearch.CounulsfledghngCommit-. ~ t}~Ce nn gublrc Information in the t~ r Pre entinn of Occupational t.aneer. -: ~~y' later this year+th¢ <umm,ttee~ ; g~t~s'will.be recommending W the Occu ~ +dpatiunal Rafely& Healtn Adminis- ~, ktration and the National Cancer In- ;~ t atitute gutdebne> for what mfurma- , 1~,tbn on cancer ifsks shnol& be ; -•' provided to .iiemplovers 'and 'y j trnplu}ees as well as how end to il ~ whomlt ahould be presented ' ^:n'. :. `-v!>C\Yhat information to include in a°-~ ?iafet> - alert s3slem'is,a nia or prnh- " J ..`~lem:biust speakers ealledi fnr.in- ` sluding unpuhhshed riskk data'in the scatem.. since publication in a ~,, referred journal nften.n follows cum•' ~.`qletion of a stud.v B}•morethan a '.v[ah B11t',`_aa mmmillee membrl• i)r. Paul F.•SChil.e of John Hnpkins ~, _Universitn pomts.nut, warning too y - often aht ut chemirala that turn out ~, to he hannte.+avill redbce the effec- ~'. twenes nff the proR+nm. One s}•s-" ,,tem. lS .hite. says: miKfit be to color ~r artie all chemicalk fnr differentlev- el.nl'certair.lr,ali.n•t the risk. -' ti: Thefirst zlep in any svstem is tn r~r`„(}¢II wtnkers.lhe nnmes , of.the t•om. ".;punds ihes wi.rk wilh sbys Jle-~, phenW,dkruftheilil Chemiral& ', Atumir 11 t rkers `,nirniatiunnl , '~-l6niim. He call, fnr immedint4 idem Y~ '-vhruion br w6uerie nnme nl: illl pl ~.trnd.nsmed rhrmirnls in the work ~j p[ace.. Others ah:o are cumvnx6l • with'the qtn•nliun of unAnnwn expti- ~ Z- -ture' w dan-enm+ ohemical. in -'; Jtradenamed pradurh.. The\ati,ma{ Jnstitute for'f)mtpmii mF Saiet7 8, •~-;;Heolth purs•e}nNl afkglI work plmres I -'_ ru 1974 and faund that .I/aoaiM• of•~ the suhstanre..wurkers urei•elurcrd j ~~- :. to are Iradrmtmrd pr,dmlx Gn 1.'=whii+hilhe.nca-,ni,al hqlretiiinqs and~ : '. their mncentraiinns arr nor readi:v' :, n•ail:dile. : NlilSl I pre.~•ntlr, i. i,.. --- JtrackinK dnwnn the nmtptm.-nu of ~ -.lhe.r pratiuotsA lu find tnii M'hich ' `chemii•al.ur,rker.ammt..t'.eslwrwwl ' En in variuus iirdu+trii•s..\nd l'un- ~` greae mas. (-it hmkingintn Ihe ctli+cL -, ui trader tmtdpndu[I ut wdrk¢r -Wfrlylalerthtsvear. 4, ' ' 'iar...:d r tormsdon that Is nnt ber.kedl up hy regulatinm mnlrnl-~t ~.bnq ¢xpasure is Lkel}'to h•nr htllr"` on employees,.{sa}c Barrv.~~[ ', 'Cantlerllan`,4fin environment9l cun-)2 ' euhant. He cited efforts to tnfnrrn'~ / ^ automnbiie mechanics of lhe.dan-: y -i~~ - ger of nsbestns expasure (rom ?i h nte linings. •Followup studies'" f und 'ont• ,about -.-5% of the ~' iemyl,veea aonpted safenwnrk pro-'q '° cedurr aft<rthehazardwarnings.O.' NC/STRC TEChN C11L $(iL TTN :r Feb.'1976, ho 58 Ttem 5804_ ~.r et~ fyy~..}+~~ I•tem 5811 d ,. 4 WR '}L}nu? ';1, Y f i " t 7- \ .:.Yr~ _.~~ '' y ily 5 a3 ~T If :.. "7fr.%'Q'! . R~aA,,.' ~'Lw ''dl+.~,ft r~R F .,. 5'C In _'tiuaercusjtoxtc and hazardo,is wastes arel beiing generated and .fmprop-,_; erly•treated/disposed of,by industrialSources £'r-arr:a'ri~ Tecnn.~;aea Trect.r.ent' of:Ileaard_ua'waatee was.undertaken to fdentif.,and recomrend '.;promis:ing wastetreatment technologies fheuse of which.would Tinlmize -=thegrowing threat to_public health'and env:iiorlmentall quality ra '" ,.rture searches, site visits, anif personal`aommunications'wtth e.cperts in `-: the field provided the basis for identifying needed treatment 'cechnolo- -~gies in this National Environnenral Research Center paper N75 1'45, ~ `~iovember 1974...45p . .-.. , . >Z%' . EVC2u¢tion of ,,a..ards -Associati3 sn.th S~Z': + u!,QeoLCe.,-,.e •hazardsassociated with munlclpal solid waste/seua esl dg ~su i g u e ar mna ! aiLad.and.^Avalwated^- ;..T,he occurrence and_ survrval of,'pathogenshyara ..process are described -:It is_concludedthat a-properlyecompostedVsolid " ---' ..,.,r=.,oy~ .e ,a ,~~~~ruototugrcaity aceept- °.able as a soil''l conditioner for gardens, farms, and lawns, or forfill!ing'-. " areas of ~- erosion. N75-32641, April. 1975, 56p• ty, r p ,. . t ~ ....... . .. .. .... _. ...... -.,, _ e ~ .i_r . } :V S' tF. s6M
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BOOK BEUxEWS On-line colnhuting "Lolxnarary On-Cinr C'.unfnnine: An Irllp+drn'(nnr hr &rs•i,u•ers md . rhysiri.rrn Uy 1.. F-_ ifrignell and' P. M. RIn.Jcs I'p..xa.297; tlntam+BOnal Tcsrh,wks: Lcirillun Ru,,,ard, Sep. temher 1975.) [g:73. .: - 71us': Lnkk setr mn to intrmluce ' engineenandphyxicisls m un-line comp.ting. The..ulhors wisd, uin- Rne themalhcs moslly. eo generalitie.s .' hotlat the same time Ihere is suhicienl depth of'desailf too make Ihis' hookk or . aeal ux topcrsons entering this Nm- .x piex. and rapidyy developing fieW.. Tscn early chaplersinlroduce the ~~ ~r:reader to the hasic elcmcnls uG both hanlwan:m and soflware, asrumingg a ' level M knowledge usuzlly gainedd in nunt cnurses in enpinecring or. . ~ ph).ics-a gaed stzrlingpointg slut.ilt fa in geltiag to grips wilhIhe real ' profilnn-hardware-suftwnre inmr- . actinn-Ihat the~ authors exceq wilhtheir ahilitgto ddiueate and explain the ssenli:& features.of interfucing.: " Afarryeompiexdcsign, features of - hothhardwarch and software are lxpiiiincd, with a' Ineidily wlsieh. ls . . krtlLrefre.hin3'.and ivatructice. - `. . The nuWurs decoso,a I.uge.section of their book 10 a much neSl<eted suhjecl-Ihe comr9ucnccs of inter- fa inp the real eonlinuuus< wurM to Ihee di.crelivd sorld of thae digilal Computer: 'fhee reader is inlnduted ver,r Sently to Iheoriesofsamplingand.digi®16itering. There ara, howeser. nnr or two sprpricing nmissions.. There Is an dnence of detailed commcnl on, for example, eilhe* the influence of operalingsyslems on reabtimee mspunse, or on modcrnprogramminglechni9ues which are important for mcmun•slarsedminicomputers, fuch as suhrouline fe-cntruney. On the hardscare side the ubiquitous asyn- chronous se.rfal line unit is not menlioned: On Ihc whoie..finwxver. thiss is an escellenl hook and anyone Manningfo "go on-linc"w'i'A cenainlc find,il', . of great henefit. Researchworkersand enginecrs airendycsperienccd in on-line compmingw'ill'Cadg sectinns. whichh make intercNing and .alunblenading. P..P..Ki1sS V©L, 6. WOa 6. MARCH 19, 1976 Analysing metal compounds ~ Mars Sprammrrp~ n/ Merd~ Cnm- . rmmdc Edited hy. J. planlamfitma Pp: 297, fEuttcrworth: London and Boston, hiasochusetts, 1975.) n:p: Tsla first'four chapters of the hook deal with Ihe..lheoryof man speetros nletq'. instrumentation and teefl+ niyues. The next five chapters arr . concerned with specificc groups of metal compnunds;, whercas theIast -' chapter discu.aes analytical aspects .of the massspeclrometry of metal ehdates: Finally, an appendix Pvcs.• table of' nusiidic masses~ andabundanees of the naturally oocurring isompra There are over 400 rcfer ences, man)-of which oocur in the literature or the pass decade or so;, illustralinp the rapid growth of inorganic' masrs speesromctry during. . the pcriod. Thcrem are a fcw, minor crilieisms of the hook;. In Ihee first place it is aurprising that in a cnmprchcnsive resiewofIhe energeuct oP molecular.. Innisalion, noo mentiJn itmadf of the electrnn monnchromamr of Lna- Ing: which pmeidcs.Vhe mosl aeeurale. ~ melhod of dcteimininS ionisalion and appearance polentials by mass speclrometry, Again the classical' eyuation, kf£i=uffE-8J!£)"' isuscd in discussing rragmenlalioni Cinelic; in spite of the facl, that it. Is known loo be an exlremely bad approximation. On the positive side- references arem made too studies of negalive ions, which are becoming inereasingly imporltnt. Withia the confines of production frnm lypcsnipt, the hook is""well produced. It should berome an essen- lial addition to the.lihrary or anyone working in ihe- ficlds covercd. Allan hfaeeop s
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: 84: 39889f Complex formatton between carbon monoxide . " "~-' 84: 50302ellUagnctic nnd infrarcd sludyogenrbnn munoxidc . s~ertrometry (MBRS).. Fremk measured as.a function of temp., . em. ToksyknL 197a„ 813), 368-7d (Pol): Levelss of ' the desorptioni activation energyand pre-exponentiali function carbonylhemaglubins: in hlbod'.drippibgs frum the lungs of human . were deW: The resultsagree.with thoseirotn flash desorption(Jl corpses correlated well with levels m cardiac blood. L:evcls in the I« Falconer and R. T. Madix;.1975). An advantage.of',S1BRSfore braimand spleen were usually lon•er: Orean samplesmay thushe studying adsorption and desorption kinetics is that desorption useful imI toxicol. anal. of CO [630-08'-D] poisoning in the rates can be studied at lmv surface eoverages (0'-- I0*s)'so,that absence of blood samples. mmplications.obsd_in flash desorption can be avoided. . . . . . .. . . . '- used asrefs for the anali of protein in milk„was the:object of a. •onlymetabolic reactior.swere.produced by FCaI at 54, (vs: no •;, comparative study' between different labs. The distribution of. reaction for 20% FCl2 or mixts.), girtng a slight hvperglyeemia the results allowed,anestimation of the reliability of the methnd. .. with hyperlactacidemia. In prolon^ed exposure expts. (2 hr/day" (accuracy, precision, objectivity)as wellas.ofthel importance of: • for 15'days), onlv FCII at59o proTucedmetabultc modifications. " the.test conditions in each lab. E. E:.Gansel .' those: modiGcations's being quickly reversed after inhalation . . .. .. . .:.....:. . ... _ ,-:..;..,,.,,. ., . . - - - ceased. - -' 8A:50206b ~Iolecularbeamrelaxation.spectrometry(M611S)'' ' measurement ofthedesorptioarate constant for carbon. monoxide onn nieke1(110): Helms. C. R, Madix, It. J., . 84:39400q Carbony]hemoglobin distributionn in various ._ (Stanford Electron: l.ab:. Stanford Univ., Sttanford, Calif.6 organs off the human cor S . Surj, Scf: 1975, 52(M1)r 677-80(Eng). 'Fhe desorption rate. .. (yakl. Med. Sadowe psc. Troj,•tnowska, Miecz ~slawa k for CO on Ni(It0) was studied by mnl. beam.relaxatton Ck L. Akad. ,\ied... l.ublin, Pul.):. Bromatoi ` tonat •84i42082t Com arisonbetween.laboratoriesoftheKjeldalil. ~t, rabbtt, and dag. Peulet, G;, Ronan, G.,, , a, , P ....Toulouse, P.; Dassonville, J. (Lab, phlsiol. btcd U.E:R: 1fed. method applied to total nitrogen determination in milu.. Pharm., Rennes, FiJ. Toxicol. Appl. Pharrnarol: 1975, 3412), . Bosseq.J.; Steiger,. G. (Stn. Fed. Rech. Laitieres, Lieliefeld-H.ern„ -197-203 (Engl. TheflunrocarbonsFCII' [75'-69-J] and FC12 Switz.l Mitl. Geb. L'eberssmitteluntecs. Xyg, 1974. 65(ll,. (75-71-8 1 were inhaled by the: test.animais either alonee in air or 470-5 (Frl. The Kjeldahl method of N(7727-37~-9] detn., often • tombine as 50/50 or 10/90 mixts. In single exposure expts., the ; apnmoddted stateinc pable of CO btnding.. u.i~:.t, .~- .. 84:54989g Fluorocarbons and general metabolism iin the V'dI E• ; when 1 ts etther tn.a htgh'spmatate or tn astructurallymoddredi - trenslnted .t•a. " -, ! .• form• Apparently,, during redn:, suchh a structurally modifed' :form of I occurs as an intermediate which slowly relaxess to a . •. ~t . . -~• before the low-spin form,Thus, compleaatiomoflCO only occurs~'From Ref.. Zh:. Hhint. 1975, Abate. No. 17Iti83• 'L'itle uuy . In tAese samples, hiBh-spin oxidized I disappearedi ~"Bkeperim: ln-7`GipruuRlr•Rnrma+h1977; (1D1! 227-Al (Itusst. oxidized I off romplex formed was proportional to the amt., of.-I (~UtiSHI. Sh.. Tr: tinrnennd: N., f.. Ihockt.-Ar,rmtrukt... I :, dhe, amt . .i amt of complex formed decreased wtth mcreasrng time I'ag'. c s• Ing. . between the beginning'.of redn. and~CO.addm, and asymptotically t ;. r,car ',epproached a level equal to~o that of the conen. of'.I high-spinI ', olttdtud1. When samples contg: equil. mixts. of oxidized and.. ''t}f: 49469h Polhuion of lhe atmo.phrre by curhom monoxide reduced I were subjected too simultaneous redn. and CO addrt.,. and ways of reducing it. I(iuo„k. K. 1..; Vaikuvskii, V.. 4 s a a '! However, if CO were added'~during:the redn. of oxidized I, muchI .. e angu r cun guraUOn wherc CO is.bridxcd"over $ Nt -mme carhonyleytochrome c was formed. During such.expts:, the stoms. The ratio uE the 2configurations changes with temp. . HL S hl' ht a g sorp ton >an . at .105 t 20 etn- I to the hr.ear ivr-l G -.I rapidly bouad CO (orming; carbanylcytochrome q thee amt. of '. oonfiguration and bands at.19:10 f 5 cmt to the thermodynamieally . whlch was directly pro rttonal.l to the amt. of' high-spin L, - I more t Gl l f o ttor oxt tze orm uun B mcreasedfrumI.2 to 1.8 between -78 and 200 whik remainin; -atrength~, Part.of the low-spinoxidixed orm.of I waa converted - consh The ii spectra at varimus temps. are mte:pretrd bv "to the Aigh-spin state. After redh: of these prepns., the reduced. "~ relatin b CI d• ~' rome e ec of CO on Nt catalysts.deposited on SiOn was atuthed.betu'ern.-79 •.. nder steady-atste conditions at pHl 4-9• neitherr the reduttd -and 100°, G r~• f I b d CO' At H<y or' at hi h ionic y ir and magnetic saln: metlicdx• 1 he ratiuNi, C 0 'd' d I The electronic configuration andthe conformattonal statee of " ^Acad: (1) n essarv forits reaction with CO were studied Sri.,SrcC 1975, 28I(I S),G07-10 (F4L Thechemisarption Burbaev, D. Sh.;Vanih, A. F. (lnst.Chem. Ph}x., Moscow,. Joaehim; trrimet, Muhe1;', IGdwnn Iran A.;M,rtin, F;uy A. ""USSRI. Mo(. Biol: (Moseoul 1975, 9(6). 934-40(Russ).. •-~ (lnst. Itech. Cotnl., Villrurbnnne, Fr•): C, R. NcNd 8,wnrra - aadl oytochromee c. Belovolova. GV; Blyumenfel'd', L A.;: -- -" ehemixorplionan niticn .upported nirkel cntaiyaw Anw,r rc 84:51975x hlechanisms ofoxygemdelivery to the.tissues inn individuals with chronic low-grade carbon ntonoxide exposure Goldstetn H D.; Gnldrmg; K. MAmpnw4i, K L. htich: Med NcwYurk Ilmv., New York: N. Y)U: S'.. NT1S,. frd! Rrp. 1975,PR'L4dl.r.t,. 21 'rpj . (Ring). Avail. N I'IS1 p'.omOuu: Rcp:.Annnuncr. Ltdez (fl: S 1 1975. 75(2>)58. This study --evaluated 2 parameters related to blurnt 0(7rN2'-i4-71~dclivery inn employees of the '1'riGnrottRh Hnd„e and lunpcl Autltiaity ehronically exposed to automobile exhmtst: red hkwd cell'i mMhemoglobin levels and red bh,nd ccll '1;J-dtpljo.sphoclvcrrlr oeid' [138-8h-8' levels. A slight but statistteallp signit7c:mr elevation in metfimrq;lulrin levels was noted. In addn:. a trend Gnvards increases in red cell2Sl-diphosphuglyceric acid..cnncnsd w•as discernible. Cigarette smokingg appears tu arntributee to Gnth of these findings. No.evidence of an elevation in hematocrit levels war.obsdl, g4:,55067s Fate of fluorocarbons in the dog andirrabbit after inhalation. Paulet,.G.;. Lanoe I.h Thus, A.;: foulouse, P.; Dassonville, J. flab'Phvsiol. lledl, U.E.R. Med. Pharm.., Rennes, Fr.). Toxic•nL Appl. Pharmncot: 1975, 34(2). 204-13 (Eng). FC17 [75-69-3].and FC/2(75-77-81 when inhaled:in concns. varyingg frnmiq to Sa and from 0 to 5090,, resp:, rapidly diflused into the blond: cerebrospinal fluid, urine, and bile, where a balaneed.condttion was quickly established. The concn. depended on thecunrne inhaledd and the.conditions underr which this inhalation took place (11 gasor a mixt. of the 2).. Appearance (1 minl.o(these gases in the ccrebro.spinal fluid was.quite rapid, thus explainingthetr actiumnn the central nen•uus s>xtcm, The elimination of these gasesfrum, thc body was cumplete& 20-50 min after freshiair was reinhaled. 'fhiselimination tnaokplace primarily (98`l0) through the pulmunary systequ Bile and urine eonstituted onlra minor pathway nf excreuon.. QUU091"72 . vOL, 6, No. 6, MARCw 19, 1976
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d 84:133S2k Synthesis of.Co-Ct. homologs of btphenyl and .- i rdiphcnvlmcthaae as ehromatugraphic' standards. - Krnr. ^; ru Jost.i;: Popl, h1iiant Hala. Slavvj; Moseeckq, Jrn ()~p. Pet, ;„ Technol. Petrochem:, Inst. Chem. Technok, • P4ague, Czech )• Sb. Vys. Sg. Chem.-Techno/, Praze„Technof. Prtfiu1973, D29, - 4966 (E): th Gbif RNiCI (R1) .-ng Usingeomerg reacton o•- =ary . pitharomh hydrocarbens; the Nurtz-Fittig method and'other. . Drocedures,3isomeric.bleCaH~Ph,12isomericdimethylbi)rhen}Is, :9isomeric EtCsHtPh, Ph_CHs,and.4: isomeric methyldrphenv= _ ~'Iinethanes weree prepdi The reaction products,, which usually erized Ni~„~tent oon and riellati epamis: of therindt idualbisomers~deThe pddful itltd inh ,cep. contps. were use asnerna ss. gas cromatog. .y . :.84:535747'ADparatus for- tieatment o[ analogiodata , {•:espccially for gas-phase. chromatographyr Blitzsch R; , Coustre,A.; Collicr J:C (LignesTolegraphiquesetTelephoniques) , . rr•:,BA C 820,107 (Cl. GOIn)i 18Jan 1973;Fr. App1 7335,70I, O5Oct 1975: 29 nn. - An aou. is descrihed- fnr ororestinet ea° `.84:56010q Portable laboratory~ forr rapidd detection of ,..,. Y.,: alkalbidss in fresh, . plant parts under field conditions by' . . thin-layer microchrumatagraphy. Stefanuv, Zln. (Nauchnoiuhd': .khim: Farm. Inst., Solia. Dul>.)• Farrnalsi •a(So/ia)' 1975,. . 25(2); 47 5J IIAdg).. The tit~e Job: was developed for the. ..-~:, detection of alkaloids in the field and for the'semi-quant detm known alkaloids. The tot.il'.w4l of the portable systenr is -5' i!,,_ kg, and 90 samples r.mbe analyzed, with a'total run timeof 30. ., r mrn fur a series of tnvesttgation: -®4: 46594j. SamPlcd-dataproportionnl'.eontrol of a flow-fo= rced.tubular reactor. 1ludmrnsan: Rajakkannu; Couitlianowr, Donald R(Dep: Chem: Eng:, Drexel Lniv., Philadelphia, Pa:). -" Ind. Eng.'C1iem.,.Proccss Des. Dee. 19T6, 15(1), 141-4 (Cvng), Though conrinuous, proportional: feedback conuol'wf an isothermal _ tubular. reactorr is always stable, sampled-data, proportional - control'can make thee system output oscillate indefinitely. .'-'Through anal. and simul.tlion it is shown tliatt for any feedback gain,.tliere is a magnitude.of stcpchan^r in inlat concn. tliatcant eausee the system output to oscillate indefinitely,. .. °$4: 44S43r Noloof polymersAape inithe GPCIgcl'Permration chromatogrnpbs'I separation mecbanisnr. Comparativc studyof nRid.rndlikc polp(butvlnocyanatc)l flexiblocoil polystRrcre: nnd SItS ~stYruur--hut~dii~nc-siyrmua block 'copolymcr, .nnd rigid vphcrclil:r randumly branched polyst= "yrenc: Ambluthlichacllt (Univ-Akron AkrnnOhio): 1975. S5G,pp. (b,n„1.Avad. XeroxUmr lkticrofilms; Ann Arhnr,. '. Mich:, Ordar No: 75:-23,973, From Diss:dbsar. Inr; f] 1975.,. 30(5), 2218. 84: 419JSt Effect uf pruductsof the sugar-nmrinc reaetionon Ihrqunlity of color used in thrbrandi'e induMr-v: Ni;nrov, I. A.;', ISerruuuv, A. A: Lomirmdc, V. N.; Skripnik, A.. Yu: (lhst. Riukhim: im., Sakha, Mu.rnw. USSR). Vtrrodt•f: Vinugrad. JSS/t,1975 (8), 51-2 (Itius),. l)uringhoating of sucrose to 1Mlt -9f1°~ furr. 10 1?0 min, pHH derrcascdd fram 0.8 to 2.6'6 and a nu. of cul6tile ICl-C01 and nonrulntilh (Lirtaric, midnnic,, and surcinirl acids, rarhuuyi cnmluls. Ifurfurol, CIIr6.,CHI:d:HO„ acetont, isu6ulyraldehydcll; andi IAO'H were fonned. Iht Ihee presence of 1f.P5`h nmiuoo arid, the reaction rnte incrensed niany-firW and hii;her, alcs: were alsufurmrd... 7•he praduets may alfect taare when used as a coloring agvnt for brandy:. VnLr 6, 110. 6, MA'RCH 19, 1976 '-enromatog: analog signals . which.senses the time at which lhe , "' max. signal'occurs and measures the area.underthesignal peak "minus.the background area.. :.-, 1 11 -. . " - "r- ru 84t• 40417d Quantitative determination ofsugnrs ictfaclory - - ,;.tproducts by gnschromatography using open tubular . eolumns. Ntuuk;U.; Iteardon,1'..J (Sugar h7illmgHcs. Inst.,. Durban, S Afr ). Proe Anmr. Cort r J..A/r. Sucor TeehnoL 1975, 49, 94-8' (Eng). (:fucuu (1) [50-99 7J,. Jructose,. "„,IIH. [57-48-7],. sucrose (IlU (;i7-50-1)„ snd kesln.ca in ';,.,,;.molasscs, juices mtd Vlll' sugar of sugar manuf were det<L as .. . trimet0ylsdyl detivs. bygas ehromatog. on open tubular cnlunms. The std. deviotionsof the cliromuu+K. anal• of.molas.sesuecre0.3f for 1, 0.37 for 11 end O.OG for I[i. 'l'hcadvantogcsof usingthese. columnswere also discussed 8i: 502fi7x Gel-pcrmcatinn cbrnmatogr.tphy uf sillvr solul7t ions in surf;rct:mis.. Ne+tcruv, V. V.; Bulhnikii, It. 6.;' -Kuknluva, 1i 1.;: Neladnv„ 1'., !'.; 'llrhnnd. S. I-. frnstQ=tu Vbsokumnl.Snrdin:. Lenm„rad, 1IS51U. Ifoffntda.'/.h. 1975,. 1184 6(Itu.s). Gel pcrmcatinn: chrnmalb;;. wa, used fur the 1sC time for anal. nf sulns. contg. iuns and rulli,idnl partirlea, " The colloidal enntrnll inan aq. xditu nl' nuniunirr surfartant after its.spnntnucnu. disoln:m Ilus suln- is 5/.'I•he elruiun curecs' for imtic :mdd enll iidal Ag werr mmlyuc,dlysepd•t the mean aiv.o "" of colloidal particles is 7 X 10? nn. .. 84:55985r Analytical systems and analytical melhods. ". bascd''l upon APf (atmosphericc pressure ionvation) mass` ;lispectrometry. Horning 6.an,C.; Carralh D. 1: Dnd.c, i.;: aegele, K• D.; Horning.. Majoric G.; Stillwelli R, N. Unst. ~"Lipid Rcs•,. Baylor Coll \led., Houston, Tex.). Set,. Approuch s GasChronmtoer-.Sluss Spcclrom. Lab.11cd., Car.f. 1974 (Pub. I975). 84-105 (L'-ng): Edited by h1elrille,. Robert S:; '' Dobson,.Vivian F. U. S. Dep: Heallh„Educ. Welfare, Nath Inst. Health: Bethesda, A1dl Areriew with 12 refs. describingg the API spectrometric system for usein binl. and clin. nnaL . 84: A673°_cPurifying. gas, mikttrres. Tsitiushvrlt, G'. Vl;.. Andrunikash%dt, 1'. G.; Sabelashvilr Sh. D.; Lrowdr.c,.S. L:;: Vasil'ov, S. Z.; I(al'tsevN' V.; llctUchevskii., V. 1, Lipkind, B. - A;Maergotill etal USS.ii.487,993(CL.B01d). 1.5Sep. 1975, Appli L 94(1~A59, 27Jun 1973. From Othrvtiyo, Izobret:, .Prom..Obrn tsy, Tarmrnve Znahi 197552(3a), 13. Areolith w•itfithe cmnpn. (0.G5-0.72)CdOd021-0:3)D+a:O•(0,15-0.2)Ca0•:\IzOo•(=2:4'--3.0):•SiO,,is used to.remove CO mare completely from gases lhan do otherzeotites while"also removing HzO and COr. .. 84t53597r ltolc.ofwall-coatcdcapillnrycolumnsinGC-hiSe tgas clrromatography-mass spcctromctry.j tcclmiqucs. Egem,. J (Res. Dev: Dep., LKII Produktcr AD, lirontma, Swcd.): ~ Chromatographia'. 1975, 9(9)' 1d6-62 01ug). '1'In• ccusitivity off a<apillhry column gas.chrmnatug,-mass speatromctr}, connegtiom. wasstudred with respect tu low~ statronary phase biced,, highefficiency, and low sample capacity of w;tli-cotted capillary Q. columns. Dirertt coupling, audd connuclion via a 2 singe jet (QZ separator, were compnred, and theinertiress of thc slainless.ateli interface, in.relatiun to chulhsterul, n•asdested. . ~. %1 84: 55987s Application of intrgratcd gnschrmnntographie and ntass speclrunietric metltods in tleo identification off urinary cunstituents r.ul:rled by liquid chr+nnatography.. - hiFochek, Juhn E(OakHldgr Natl. ]ab., Oak.Rid;;c, 'Penn.). Scfl AppruneRr.v. Gas Chrumnto;r.-Afass Spettrnm. Lab. AL•d:, CanJ. 1974 (1'ub. 19-ro1, I0ti-31(1 u):I:dited by hfelcille,. Ruberl Sl: Di,hean, Vivian F. U. S. Del). Health„ Educ.. SS'elfare.. Nad. Inst. Iieallh: liethesda, D7d. A reviewwith 18 refd. describing thee use.ofg:rs rhrmmrtug, (GC), mass spectrametry'(61S), and cntq>IerhGC115,. Sornc ehanruteri,tii•s oftrimethyl-sdyl-de.rivatvcd! urinary runju;:,dcs are Preaenled also that providhciuvsia compd. rdcntiiirntmn: Finally, tiic identifiuniou. ,. procedtncs are tued to det. the idantilyof 2',urinary metabolitcs.
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:r r S:BfRIEF Na:: INK BLP~:EEN CADICER, ` xQUA1uIT a,.;GFt WATER EYED ,sGreensboro`Daily News ~° ' b ` -]10 ''1976 '' "A2 ' P FWAS1iINGTON - The quality of the'natiort s air and,water ' '°'ta improving but there is increasing,evidence that human cancer r?' Is caused in large part by chemical!substances in food, drink -:3 and, air, the President's Council on Environmental Qualitysald *~ Friday-,4.4C ~r16 ~S°_'s tr~E ~ Tfie council also wamed that the estraction of'oil from ' shale in meet growing needs for fuel may have an enormous vironmental rice"tag in.companson with more conventional ,methods e~Fo Administration tus supported'ahale oil praduc- , lion;: but Cangress,tumed down'.the most recent admwstraCron s proposal to 6nance its devetopmenti ~y,'i~~ p F The thst ehapter of the council s 763•page:rnpozt is devoted t to the concerns about carcinogens (cancer<ausmg substance5) ;`fhe ieprirR cites W rld Healih Orga~t~oa udy ttiat es ~imated 60 to 99 per cent of a4 cancer is related to environmen '_talifactors '_'They include,: among others, thedargecomponent ofl'ung cancer attributable tacigarette smoking, exposures lo chemicals in the workplace "and cancers from natuml agentr suoh'as solar andcosmlc radiation, natural asbestos and a[Ia auu (a class of chemtcals secreted by some molds)';~; ~. ~The ieport nates Iha [here~has been a`sfeady ulcrease in { „'the'..number of.chemical compounds but that'' "we knowvery i• little about the possible health consequences of ttlese new com pounds t" r,_- rr~~a ti x. t Other govemment stu~dies recently have eited ponuse liiks s'- between human cancer and exposure to asbestos vmpl chloride gas and other chemicals The Enviionmental Proteotion Agency,.prodded by re- search from the nonproft'' public interestgraup, ihe Environ y'r,'mentalDefelueFVnd,foundthatpossiblechemtcalcarcinogens • minute amounts were 'ubiquitous In the nauon s drinking -ewatersystems ~~ 't:The eouncul said r The adverseeffects from some (chemt ca[ ~eompounds)) make it. inereasingly probable that chemical contaminants in our'environmental have become a.signclcant `r `~'determinant of:human health.and life expectancy." „,~~i ~".' In reviewing cuirent. technology idnew energy sources, the -y. - council said the most promising appears to be:the use ot solar ; energy the sun'sravs to power heating and cooling planta ,; ~ ':forbuildtngs ~v`tk„S' 1':',~'-The production of syntheUc tuelssaises a number of en.i- ronmental question„the council said. Nocommeraial-size syn- - •" thetic fuel~ operationl has, . yet been tried,, but the council has ^~ mad'e some estimates of what.itwould take to recover oillfrom ; shale in the:amounts needed irtthe ear2990- e~~,~,~~4.. K wf A, ::.,5<.f OL : a. 1. J 'I~0 ^+ts±xar~. r-str~m srz=x» ,, MARCH'I'9,''197 wvw;ispf~" N V "Solid wastes (residue).would be almost nine times theto= '{ '=..1a1 U.S. residential and commercial -.i5-"vollune In 197J;"the-. ,~ councilsaid..The daily'waterrequirement oC417million gallons.- .?jto recover oil from shale is"enough.to.supply the daily-6ouse-' . ,-hold needs of the entire population of the Washmgton, D.C.,_, ~. metropolitan a.ea " the report.satd r ~~ ~ ~ , . - .<;i~ z. C-1- -,. . .. - ,~„ ,a'm,u,,~Improved teehniques 'ot. reco' venng crude'oiP, according to,; ~,. " , the council may present a very favorable potential when com-, • . pared with alternatives for producing synthetic fiquidifuelssuch ''af .-_ hale od ;~,'q~, y~~~; - ' John Fogarty, a spokesman tor the i'ouncil, saidlthat~- If cumment did not mean the council Is criticizing the President's'V~ , +', support of shale oil productioni ~~. ~~~a>It's our job to raise environmental questions when we (ind ' tfi ^~",~'~ them„' he sald."It's-up to the Congress and the President to weigh'this information most positive aspects of the report are . In the areas of a` `watanand air.pollution ;j Between1979.and1974,The.councilsaid,.particulatematter,;i, ~'per cent~carbon p onoxide has decr ased112 per centranLehy f3 i1s ha e declined about 5 per cent. 25 TV"C' I 'liT 'e+ s.~'lu 't `~ . Q'e~ny~~~p~~ * C&E NEWS Feb. 23, .1976 ; Vol. 54,_`no 8. P9 ' .• A patenrbill, S:.2255; approvedearlier this.momh by ` the Senate Judiciary. Comminee, allows ehallenges " z{_`to a patent's validity at anyt!ma during the life of the '.-patent, but not before 12 months after Issuance:. Yi•~~Y~i,. Laboratory and medieal use of raddlpSactlveimalerlalc '"6 nat adequately conlrolled, according.to the Gen- erallAccounting Office.'Intiscall197d, GAO sa -~~ ys .- ~ ~ federal Inspectors lountl more than 2000 .~olationa among"" Y ~. ~.among academic, medical,. and industrial usersot ~. i such materials and more than halt of 7he violations "'were-malor enough to Aave actuallyor potentially ' ",iesulteCin rad/ation.e.posure toindlviduals or in re: ' ~,kaseof,radlation mexeessof'permisslble,limils." ° The vlolalions Involvedi among nther things;,e.ceed• ' ~ +,~Ing. permissibledoses,levels, and <oncentrations:at ?+adroactive nuterials' and failure to measure radia- :-non levels V { K t ~ 1 Y CA 0 9 S
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, NEW LITERATURE BOOK REVIEWS Polychlo eoaromatics PulyNdemwrvmarie Conrp.nnnlz EdilcJ by gl. SuschiVky pp- viiii6/7. (l'lannm: ficw York and,Lon-don,. 1975.).592: '_ Mrasnt readen will find this' bnnk or greatest interest it they reud hrsl the qsl ehaptcq which iis a eumprehensivc. . and s.timulatingsurs'ey M Pd3chluro• aromatic and -IIctCRqrOmntll' CIrnH pounds of industrial impurtancq, by-' M. 8. Green of ICI Nond Uisision: ' Dssecticidts,.lungicidesi.herAicldes andi 'othent are.e eosered together withh eertain polymers and djtstulrs: Thismalerial gives special point to lhr'e egrlier chaplcrs;. -- In the firse of'these, Balks!tr and'. 1:_LAlirellu provide n kngthy acs-ouncuf -'.aromalic and alkaromatio thbra . earEnm which Is:ckar,.mmprchcntive and well orgaoised. Iet contains very intereNinS material on rekvant ! radicals. reactisac and.inert, and on. ear&minm ions and carhanions. IY irfnllmvcd by sinri!ar chapten.on puly--ehlmohelernaromatk compuunds andd an polcchluroaryl derisatiics of metakand' melalloidshg IBdon unJ Suschitrkyand hy:'Chi.en and \Vake-fnld. respecliscly: The range of helerocyelic corn- pounds coured is wkle, inclmliny mninlj-) mono- and Id-cyclic cam- pounds containing nne on r+o hetero- awms (nitrogcn;pc, ycn and..ulphur)'. Sin!ihsrly, the cusemg.of ineuJs and metailoiJsis cnrssprehcn.isec with major emplsusiss on alkali metalx ' stroup~Il mcl•ds, and group gJfA and. IV:\.clemcnlc particularly silicon. The inlrin.ic ehemical interest' altacheJ to all lhe,r c.xnpunnds lies in unuttrmpt IormdreUZnd their un- usual pro{urtia•airs terms of Iheeumulutisue eleatronic efftcts uf the chlorine sulssti:uenP and a•sMrt.P'nd- ing s!eric etrcesa. Some progreas, in thisdirretim has. hern madc Tho - book has a Iraditiunui 'prcpsraliun and prnpertiei Bacour. hul isra mine ot infurnsation, indicativc ufr snany problems ncaWinge furthcr racara9i. The hsukik evll cun.c•i.rJanJ well • prsduced.unaeancchapterbusafull set of'.n•fcrcnces.'fhcra• ua!as a.atis- fuctun ntnlmr and •ulsjvcl inJes. Il fs. huwner, eunw.h:rt.speciali:ed fur • nuM olgaaie thcnsi.u. Nes.Ilhclhs they are all in 14ofc•.we Suwhivk)'b dcht, for mnkinC' asailahle so cun- stnivntl, a taa unwsmt W uwiul and inleruslingg infprm:niou. N. It. CTtnpmm~ VoLa 6. No. 6, MaRCM 19, 1976 ... Faryebprd'u of Ihr. Nlktleide Valumea IuidI lBy. llDnea. S. GLASSY (ICI.Orpsnik,Divisiun Lld-). PIlnum Publishiag Curp;, Ne. York, N.Y. 1975: 1423 pp. 5g5:00. - - This.wurk Bcornp&IC in awe volumcs, in,whRh it cevcrs alka, laids frmmabrasine in xp'gadenine The substances are listed in ab. phahaical ardn,.with abom'rvo roahrcccompuunds to a psgr-.. The empirical and nruemral farmuln avd Ihe me4ing point are=. given, follosd. by a diaaunike paaaSraph of cemmenu onnhc eo-eurrence, eharacserieatbq sfxcial properties and nemions, and relarian toosher alkalolds.ln this «spect if differs frnm lhs forsnat . sf the nccmly publishcd ••tlandl.ook afN.wrally Occurdng Campnundx" by DevonScutt;.which does not oonuin diacuruve aqt i l' th lk l id or a r s a o / volumeof thii .urk' ist to- h .ye.appcar,ew, .. ever). The "Encyclnpedia" alse givesreferences, in many sases eeveral peralkabid, and in sume cases many, keyed as to synthesis, . erynal nructure: uc.. where peninent. ' Benusewfthe.elphabedcarrangement,therearc.naindeaes d- , . Wough a fnrmula indlrmight have bcen vaefal. IPwouW alsu have . been helpful to lnnw.when tha Iiieralure eovengc of IhisrapiAly, - advancingilck <caed. Ne.ertheless, ir is an nbviuusly useful wtuk nfrefn2nec, the reault efa great deal uf tedinus wori, andiiueems. . wremfind.firmplaseamangthcarganicehemisu"rcfnenoer<. , wufcc- BOOI.S RECEIVED AUTHOR: MANN TITLE: TOBACCO: THE ANTS AND THE ELEPHANTS PUBLISHER: OLYMPUS, 1975 AUTHOR: NCSU TITLE: N'. C. AGRICULTURAL CHEMICALS MANUAL PUBLISHER': NCSU , 1976, AUTHOR: NONE TITLE: INDEX OF PATENTS 1973 - PT'. 1 (PATENTEES) PUBLISHER: USDC, 1974 AUTIIOR: PHILLIPS TITLE: NOTARY PUBLIC GUIDEBOOK 3rd. ed. PUBLISHER: INSTITUTE OF GOVE RNI';ENT ,. 1965 c (G W ;
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NEW LITERATURE BOOK REVIEWS..,_ pradk:al5eanning Eleefron'Microsco- py. Jtneph a. Claltlstein anM Narvey Yak. nwhx, Eds. xvui + 582 paces. f9enan publishinp0orp., 227 West 17th St,-. New York, N. Y. 10011. 1975. $49.; g Reviewed Qv L. S. BirA.t:.Ynvo/ Re- a(arch Lodorotory, N'ashington, D.C: 20375 Thia is ennutr,tanding huok Arom' Qvenl viewpointa and should becomee theatandard teslfor scanning elet+tron microscopy.(SE!11)and iefeetronm probe sli¢raanaly3u ( EP\IA) Ilahorr• toriea andacadrmic inacitutiuns. AI: though the chapters are authured by difl'erent individuals, the editurs have managed!to melrl,them ~ihto axmouth toherent presentatlon. Four of the especinlly sntisfying characteristics araan expert comparison and evalua-tion of rompetitice techniques, liberal meuf numerical examples in the equations, many-practinf applications W illlutrale:the mncepts being de- seribcd, end n writinp-stple which islucld throughoutsn that it is a plea. ture rather ths.r.a struggle to read. The book delil•ers fir more than the title promisea because altof the theory as well as the practice is expounded in. sufficient detail for eventhemost crit- h:al reader. Theory blends in with practical esamples so that the reader neverhas to read verv.farw•ithout knowing how• the equations and con- tepts are used. In organization thero.aro 14 khap- ters beginning with an introductiun w•hiehdescribes the evolutionnf'.the. SEhf end F.P)IA. Chapters 2-1 ds aeribe the electron optics and the in. teraction with tNe sM<imen to fnrm images Chapter 5 eunrs a variety of tontrast mechanisms which ean be med in specific applications (these specializedtechniquesperhapsshould. 'have cnme later.in the book): Chapters 8-8 are on specimen preparation, Fray emission messurements; and the enalyde of thin films Chapters 0 and 10 preeent schemes fooquantitative . (a-rey) enalysis. Chapter 11 should be especially-tueful to beginners in the field becau.ee it dr.:cribesa woek•a-dayy approach tu.problem snlcina-Chapten 12 enumeratn the difficulties and ap- pronch farapecial samples, i.e..low EZ elements inhomogeneitiea, ihtcrfac<s, thin films, and valeneeeffects.llinlilg- iesl applicatinnsnre tvnsidered.in a separate chapter; IS, which 1¢this re. viewer seemed Inckinq in slw'cific ex- arnplea. The ionmicroprobe is trutef prnperly s a distinct instrument in'Chupter 14. VoLr, 6, IVor 6, MARCH 1911 1976 Thereare exceptionally few nita to pick at, but lhey are pcrhaps worth brief inention. The absorption coeffi- ' eienls referrnced inChapter.l, page 80, are outdatcd and far leae accurute than tnday's standard tables from Liv- 'e ermoreorKaman\adeur..31on1eCarbdiay.ramafnrelectrunpmhsare repeated uudoly in several places, ' notably.ChaptersJandB.Channcling' ' Bdescribedatwhat'willsermunnec- esaary length W manyy readers in- Chaprer5. Figure 26 on pa;e 293 ia~ Iround tu be mnfusingto most readers - becauve xpeciGe abscissa values repre-, aentdifferentyfi,donenerqiesfnrmeh, . -atrveplbtted;thedescriptlnnofthe .: fgure iscnmpletely.inadequate.IJo `~ mention is made of the powerful elec- ' ~ ~ tron transportprngram developed by " D: 6. Cirown; hia n:ethod ispnbably ' the:most.usefulwaytecheckonthe 'adequacyof ZAF calculations in new . kinds of samplrs and's generally far Itssmatlyto run thandlnnte Carlo ealeulatimis. 1. spi te:of admonitinns on specimen prnparatioo in Chapter l4,theincaperiencedlanalyst.may.re- • qpiremnrewarningsaboutattempting quanlitativre enalr:is on rough speci. rnms in the SEhI. All in all, howes'ar, the.book is trulva landmark in the SEM and.EP\1A fields and should be rewarding reading for novias and cz- •,pertsalike. • Ezperimental ILung. Cancer: Careinn, genesis and Hioassas. Eberhard Karbe and James F. Park. eds. 611 pp-Springnr-Verlag,19i5. $:74,90. An Internatiirnal Symlwsium an $es- piFatury. Careinogene.iswxa held"in June I9i4,iAleatqe, R'ashingrun. The authnrs and the National Cances:'In.ti. tute aretn be.congralWated fnr holding lhis timely.cunfer<nre, for finding the: right balance hetween midel smdies and applied res.arch. andfur publish. 1hg the pneeedings in leas than nine muntbs- Thefive chapters are min, eerned with mvthrxls;.multifscl.nial as-peetf nf leFhlratnlV Hlelnt//~enPala. In- hxlarion rsfx•rimema with tobm<u. smnke, rudinlinn carcimu;enesis; and ini vitru re.piratory careiniµenecis. If une. 'tus to fault the puhlii•atinn. it would Ee for Ihe incomplete and not updated ref- erence la.rls ufses•nralpapers.'1•hr.l.nk is recummendrd for scientistsinter- ested in /x-cuputiunnl and ens-iionmen- tal hea lt hand lex prrimenm l cs rninugen- ous.-.f)irlrich 1/ufJmann nnd l:rnsr 4 Wyndre, Arnrricun Hralth Fbundnr/on, Nem York ~ rt fJ
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NEW LITERATURE BOOK RavaMIs - . Ea/racpenA:hromalography.JoumalM CMomalographg {Ibrarg, Val. 2, T. - &atm end.G. Chersini: EdS. av9 + 565 pages. American Elsevier PublhShinp ,' Co;. Int., 52. VandarbiK Ava.. Now York, N.Y. 1p01y:1975, $54.25 Reeiriued by Lloy'd R: Snyder; Tech. ' . niton InatrumenlCnrp., Taerytouns.. N.Y.70.591 -- . This book dealcwith the separation - ". ofinorgenicaalionsbyuaenf.reverse- ' _ phase liquid-liquid partition chmma• - tography.in columns. Liquid mm- .. ple:ibgegentsnfvarioustypes(iom exchangers, chefeting egentsf are used . - a stationary phasea. The principal application of this technique.ie furthe asaay ofTadioactive mixtures arising . Ineithert8eatomicenergyindiutryor othennuclear chemistry. resea.ch. . '" ThefirstHve<hapters,Chapurlg -' Ichelating agents), and Chapter 93. , . (porous plastic supporta).are general In nature and cover such tnpicsis 'lheory, cormlation of extraction with ' exlracliunchramatograp8y,efperi-mental techniques, stationary phsses,. . andinertsupparts:Cnmpletenes.sim - the cmerage of the+elevant literatura is ssident here, as elsewhere ih the book. There is theusuate distinction - hetween culumn dynamics (N values): and equilihria (D valuesl: The discus- sfon of colomn d,namiss ie often dis- appointinp.inthelightofadvancesunre 197 0. The critical eole of sug- nantd mobile-phase effects:is omitted I entirely, the discussion of eolumn efG, eiency.aa adunclion of extraction ki. net ira is nftln cnefusinR. end iplate . height(N) velues are geneiall¢ qunted: srithrwt specifying particle size or Oownte. \evertheless,the.overalitreat, ment'iz probably adequate for extrac- tion cNomatography, which rdies oP" selectivitymore than column efficien-' ey fdr its relative success. Thediacus+don of equilibrium aspects is generallyy more cpmplete, although7 would hav. liked less emphasis nn the demonstra-tion Ihat slnic and :ehromatogrsphle distribution coefficients (D values)) should he identicnf in equisalentes- tractiun qstems. There is alsuJittle efior[here to genecaliee and rational- ise sepuration seletlivlly in tenns of such m,dern concepts aa the hard/su8Intrraatinn of acidt and bases. Chapters 6-8 cover the'.sepvation of actiuides, lnnthnnides, and other (lesa imprutant) species. Numerous sprcifir applicntiuns and icsamples rt< pruvided-and I suspect that une can find ahnost any se'parntiun ofi.interest hare Inr eliewhere, in the buokl.4.'hap: ters 9- 10. end 12 cnncern generat areas of applicnlion.of zstractionchrmnatog{ephy:analyxi.ofGssion VOLrI 6. I1Oe 6. MARCH I9'. 1976, products, radiotoxicoingicaf usays of Yrine; and the conecntration of trace metals for subsequent analvsis by other metliads. These six ehapten stand out as well-written,ueful, and clear. Chapter1t is a nicely.done end uee.fuI discussian iof the use dlaminar (te.,.paper, TLC)'.methods to guide the design of succeraful column sepa, ntions hfanyy useful figures summr ri¢e the srlectivityoffered by differentt stationary phases and mobile pheses:.. The book oondudes.with an eahaus- l'Ive bibliography of 629 relevant pub-. lintions lhrough esrly 1973, plus ta-Wes which detail the separations de-scribedinthesearticlee.. ' Workers involved with the anahsis of mixtums of cations, espeaailyy ra-dinaelive rolutionss should 6nd this bookquite useful..Its main virtue is the completeness with which it. cacets the prior literature.and the msnyspe- elfic separrrtimn described in the test,. ih figures, and.in lables There.it fre-quent duplicstionof the same materi- d in di fferenrchapters, but lhis:is an eapected limitation ofedlted books today. The hook also suffers from its predominantl} nnn.Englishspeaking authnrs,.inlhxtseveaalchapleteare dif6cult lo read-and:.parl,care often uncleer erenaftcr e second reading. It helpsin know in odvahcelhe meaning of severai ponIv chosen words: "hlla-lar" (pomuvl, "Co4talef' IF•I-F). . "paragraph^'(ectinn)- lu:neme a few. RrsdOr. whoare new tn the field will be frustrated hc ocnsinnal undefined ternssand perticulurh"hp.rampantpb, hres'iatiuns le.¢., N7r1'A, TOPO). The latter, hnwever, are listed in full un page 531, This b.akis generally.well prurluced, with few.typographiralln-_ srsn. Nltural Products Chemiary. Volume2 Ediled by K. NAKSURN/, T~ Goro. S. Iro; S. XATOai..nd S. uozoe. Academic Pre.ss, New1'arL, N.Y. 1975 (publiihed .Imuluneously by KodanAia &iantific LId. Tbkyn). v+yge pp. Vplume I of rhii wark was rcemtl4 re.kwrd. Thrsixxhaprer. in this volume cumpluethe mvcrage of Ihe sublect according la thase elauifiealionr. Fuuy Aeid Uerivari.es and RcWt<d Com. , pounds: Suyars; Carbv,rumatic and Rcb.dlCumtawnd.; Alka- leids; Nnn-alkabidal \ivuFCn CnmpwnJs; Aspeusof Natunl ProdunsPhauchemisuy, Thea m contmucs to uc tu bndgc theiz aapbctween wurEs on pcneral org.mc chondryand advm<ed© treauses. The wttihn uyk givesnio+r'uf rhe rs.entlallinfmmatiu On in rformtWl mrkes fur yurck.iaual nxugmnon. 7'hc orderly ar-Q rangemem of the enuiais suffrcienr for ea.y ratneval- Eul it ,.(z supplementcdby.mdee:, . N N ~
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I~EW LITERATURE $OOK'REVIEW$ , Electron.bUerophohe Analys)s. S. J. ' " R:.Reed. d00pp. Cambridge Cniver- • tityPress,.1B7.i. S965Q Reed'a text is a welcome addition to: , the severaPlaooks msw nsilnble mt the. .. thear- and practice nfbleatnns micro- prohe ani 1s prov(des a well+uga-i niud xummary id the assentials of elec-tmn uptiu and X-ray Iheor-v.. The eoven%o of \-ra,vtheury in-tltsdes a shrrt appendixon the oriKinn nsdi properliesaf the characlerislie, X-ny apectra aa well as diseusshm.in . the.text of X-ray Reneralion, matrix cf- -faata in seulids, diffraetion.,and detee- tiun:. The preasentaliun strikeaag•ad " . halhnx6elweenrthetheoreticalandlhe - practical conatraihts nn oplimumper- ,foemance of electron scanning ssxtems, ' X-ray diffraction spectrometers, pro- .. portional'cwnlera: and lithium drifted sil4ondetectorsalwrgwithtAciiassoci- aled counting electronics. Chapters on practical correction procedures: yuanti- .. lative analysis with a oondispersive de- , letlor,end)ightelementandithin.61m . ', analysis provide hotha good introduc- tion to these topics andlpractical guid- ance for amlysis. A final chapter on ap- plicatiunsiliusbates the impact that ele[tmn miaroprnbe analysishas had on material seience; petrohtgy,.aad to a_,. lesser eatenr un biulogical and medical . rawtrch. 7-he electron miiroprobe hexhecome a workhorse.inclrument fsr the charae- teriratmn, of solid materiels un a.mi- ernmeler sale. The comhinotion of ,, light opticnl, eleetronsaeanning- and .X-ray'capakbilitiesrruke it a dynamic analytical'l tuol which can be used to toakeimmediate un-line.correlktion of texturea and,compo.itiuns. Reeause of this, the electron microprohe, like.the light microsaope, is'most effective when used directly by arexearch scientist who Is both knowledgeable about hia own re- Jearchh problem and sufilaently cnnver- eant.wfth the theory and operation of ' lheelectron microprobe to take advan- tage of itsextrarudinary andytiul eapubililiesi . Reed's book is an excellentintroduc- tionand cancise, aummsrv which will aenr as a good tutor far the investigator who.could makr use uf.thisaraly[icol technipuee eitherron aneletlroa micro- probe or scanninx electron microscope. Thebonk mixht be morecomp)ete with a discusxi.m o/ aumroaed eleclrommi- eruprobe anulysisand a mure etmnsive list nfarferentes; but these nmissinnsdo nnt seriouslyy detract from its usefui- mss. Its nrganiralion, mnthrdj of pre- Rntathm, and style af.lllustratlnn are partirubnl)• well suited asa general text fin n.forrmaltrmrse in the tlwnrv and practike n( eletlmn miemprnhe aual¢. sis.-!'uulR!. )Neib/en- Gadngy end Ceoph2xire, Uniivrsityo/blinnrsota VoLr 6, 11oti 6, MARCH 19, 1976 Smrirriruf PrvdirrruoArmly.efa Ry 3. Aitchiwm and 1. R. Runsmnrc. Pp ' -- xi12T). (Camhridge Univcrsity:. . Cumhridgc, Wndon:. Mew. \"orkand Mallwurnc, September 1975.) fg:SD. ' O'.vc of Ihe movt imMrtael M^hlemru ib applied statistics is that of pre- dietinc- on theba.isrd a numlxr of ohscrvatinns; what.a future obseeva-lion willi hmklike.. In its simplcst. , fnfnt. a:. l;.... J. are n I0ali5atiunf . of a random: eariable-what can hnadd abmn s..,?IAllhough swdyof lhee problem gtws.haek toLaNace and hiss law of'succcssion, it donsnol occupy 'rpromincnt position in moicrn. ' semislical thinking. This isa pitY in. view of the importance and frepucntt occurrence ofthe pmhlem. Tfie pre-^ lenl book is a serious and successfulaltempt to rcmod).this situation:.The. introductoryy chapter contains' sumc excellent esamples and later chaplersdeal with applications m sampling lOSpe<tion, regulatiim, optimisation, calibration, diagnosis and treatment -ailocation. Throughout the lwok,. and . - particularly in, . these chapters, the Iheor)1 is intimatcly relatedd to practice . and nunaritial esampleri are given . - iheommendahle detail. The authors hase had to rnukr.an agonising.de- - cisien about the mathematical Icvcl of , the honk What they have chosen too do'o is to lhrnw Ihc'reader in at lhee dcep end sfter the gentle ihvo- . ' ducmry chapter. He is sharply. 5mmcr4edin awhoie series of tlistri- h'utinns, andwithout someexprience of probability disttihutions hee will .certainly be lost. The authors easa his wayby felland intclligent tahvla• lion of the distributions and by very. clear writing. Within the Iimits of' siae they could hardly have duhe .. better. The phi/osuphY of the hook iss lirydy Ra.esian. although there'-arr. fome dn'.utions in.chaplen 5 and 6;. but I think tl¢reader will be so con- vincedby the good. sound common senee and prsati:alrclmunce of tbe examplevlhat he udl x'areely realise. that a seriutu loust is at slake: This book is an im;+srtanP comributiuo ao the statistical lilerature. U: \'. Wndlry p el ..
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''Organih syntheses ~ Vdume54 editor R~~ E Ireland Pp xi ~-- 156 ~ ~. ChfeAunr. Iolw. 6'IMy aM Sws t5-90' ' The latest issue in thisSeriesmaintains the . high standardestablish<d by preceding 'yplusncs.. Twr:nlynwo indepcndcntly checked synfheses are descibed in the ' astomaryy style. In addrdon, a Ihf of _Ynchecked preparations fhtlart have'e beun . rce<ived.durin9 the preceding yuar is in. dssded. A developntmn of the-traditional' , practice of Organic SYnthcses' is the intru- "'duoion in this vWunse of asxounN of -. mulfiatagesynthesn:TMse.serveiuem+ phasisc the advances, made in dcvising ,. ekpim and practicable~pronvlores for the. " ' prepa!]tion of argYna: comrrounES Mnichl - - .; rmtil fairly ream tirrres- were either in- aecessible or at kastdifTicultm prepare in : quantlly, .. ' . . Several syniheusare described Rral Providee a eomparisunn betaeen alternative methuds for accumpli.hing:.a similar lrunw ' formation...Foreumplc, froditfercnt Pro- .s uduresnare gisen for the formation or It benaylind•ole and, of gemnylbhloride. An .. Imsmting cm.^.parist,mn of three of the ' secent adlptiomof IheC7aisen reuranpe ` ment on the same substrate n presented in ' Illee preparations . of .Y,A'-slimethyi-5gtho- . Iesb3-ene-5-acelamide.: et1Ul-S,i~hoi '1enr:-5-acelale„ and S,^.chukst-3-enc,3- - aeetaldehyde. For the: utility of the pro- - - adure itttlf, asl well. as for c+omparieon'with Previouslyy presented s/ntheses. the, preparation and'd use of lriflatesin thre symhesis-of eyelobutanone is included. . Carbonyl alkylation and condensation, mactiom me alwaysof prime value in. synthesis. Examples of Ibese maedonns de-lailed in volume 54 includce the formation .. of e-anisaWehydc:.u 4.4dimerhyt-2osa- aoline, 2;2:dimethyl-3-phcnylpropionaldc- hyde via alkylaiion o0 fhce magnesfotm ' amine sal4 and MrroA-hydroey-3•ptlenyl- 2-heptanone via a directed aldol condensa- 'rion; Symhesesof some macrocydic struetums ([fSJinnulcnq 16mNhanp[lo]annulenq ' and 1,100.d1eracyclo0ctademne) am de. - t<ribcd. The utility ofsulpFur-cnmaining ra - agmts In synthesis iiwell illustmted by several oflhe cxpcrimcrosdeiailad, i.e:. tlmprepamtian.ofrrurnJ-hydrosy-2-hcxe-nel via 1,3-bislmclhylthiutallyllithium. a procedurefor NO formation uf syNopro- pyWibhenylstdphoniumlluoroborate, and examples':of the use of Irimeth3lcnc :difbio- losYlate and elhylesndithliuosylate asa blocking 5toupt. Other procedures representouive of'alky% latkm reaaionsand arommzitytound'.out a volume uf tcstcd ey+rrimenfal prpucdurcs of`emralruluef yrOOrcrrmJ' Heterocycti e. eo m po und s pyridine andd derivatives Volume 14, Para7 Sugplemental 1975' editor R AAbramovilchPp xvi + 451 CAicGrsrer. Jelnr IPiIeX d'S'onr Lof 1:21 The Neissbarger - Taylor seric.is of Areat importance to heterocyclK chemiVfry in providingaulhoritativeaceounsaofvunous divisinnt or the subfect: Pyridinc chumistrywas eovered' in four vNumecpublbhcd im . . 19604: dre:book under revie.rreprescnis thr,6rst of fourdorthcr volume, designed . to utdatu this treatment and bring the . ' literature <overape'.up lo:at least 1970. TThe present bookconmins fisurchapten: ' -Pmpr:rticsand ReactiomufPjridines' 135 pp by' R. A. Abramovitah and G. M. Singer;'Properties and Reactions of Parti- allp Reduced PyriJines" 46pp by Rl EI Lyle;: •Synihciie:and Natural.Sourccs of the Pyridihe Ring' IISpp by N. S. Soodman, 1. O. Haarhornc. P,.x. hlbsci+ antonio, andA. LY. Sihwn; and 6ns8w . -Quamrnnry Pyridinium CumpOund.1122pp by O. It. Rodlg.. The prescnt bouk is to:be «cammended: ~ the varioustopics are well dealt uhHr an extensice conurnislu each <heGter s.ucll as the subject index enablesindi4ldual topias.tn bereadlly'located. The tablesare w<II'set nul, and dbnul atempr. 10 be Wmo eomprchcmive fa criiicismihat can bemadc.. ' of some volumcs:in tlfn serievr: The trear-ment isowdcrn and the book.is.very frce'e from orrars.lu few mmaih::C - 0 mhsing:g on a dbrmula on I• 91; the middle paragraphh on P34g isincorrect, the rs•aetions un' simple additionsl. . The edilor must be cmomcndqd far having:g brought this revision to a very succcssfW conduvinn: this book will be ' needed in chemistry libraries f6r a lang lime, A''k'Atn.itcar Hiph-SpaeE Llquid,Chromategraphy. Peter M. Rajosanyi and Elisabeth Rajcsanyl. vi + 203.pages3 fuarcellOek- ker, Inc;.170 fA:M.soa AveL New'York;. N: Y. 10016. 1975. S 15.50 Thismonograp7i un iiiph-speed liq- uid chromatography, written byl4n Hungnrinn nutlmrs, i.c limited toe dia- ' eussiun of liquid-liquid partition chro- matopuphyand liquid-solid adsorp- tiun chmmam,c,ruphv, The thtee chap.tors of the book denlwith(1) an esnm- hulion of Ihcuretical.hasis;/91a Fstia- factory instrmnentation aystem. and (Zi expericncein npplicatihn nflhe s,vstem: All nf tlwxc t npi<s are treatedwith a virw towxrd rvducinp analysia, time and improving separation err- cienty: This book i:a pood quality off- set copy oftypewtitten text f
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NEW L6TERATURE, BOORS b1DVAArCE9in " 574.1'91'05 biaph~sict~Baltimore; Unis'ersilyl'ark Press. • Vol. 19'S, is nox• availa6lc for 19.30. ISBN p-8391-010J-XA.C. card no.: 76',P1g663: . . aADVAhrCFSid r c:l c 301.15082,i- eapcrirnental socialpsychnlogy. New. York, AcadcmicPras. Vol. 9, Equity Theary: Toward a General t Thcnry of Social Inlcnction, 1976, is now , - available for 16.50. ISBN 042,015209-6: LC. card na:, 6423452. , .. _ . " 1 : 1.OTT. John N. A., 1943. '311.8!24 " A sn+nning Nnvsn nria•rnsmpc stmJp of grcrn. ' ~- Pl+nts. / John N. A. Lou. St; Louis :~. btnsbv. I -• 1976.. D..cm. Includes bihlinrrxnhical rcScrcnces ' and',indceJQA677.L68 75d9863ISB?f 0.8016. '=1 3033-9 : I I 93 pbk.: 7. 0 . . ~ 1. Bnnrny AnslnmJ'-Atfa.ns. 2. Uhraslnrclorc k% , (Bn)l;c1Y Adaef.f'J. SranningeJcamn ~ ' nni'nucr9te. 1 Tttlc. : Prcpmd Gunr CLP. ' NEIYYorkLibrz7 -'1 023'.9 . Association. Personnel A'dminislration Cnmmittee. Oulline af a personnd n1anitition and po/ic¢manru! / prepared . tiythe Pcrsonncl Adminislration C'ontmiltee of the Naw•. York Lbmry Association. New York: NYIA. (19751 12 p: 29.cm. [7.G82.N4.i819i5J 76-350008 2.00 J. CiDrvy pcaonnc/ man.+;ement. I. Tit/r. COWLES,.Laurence 621.3X15'3'0J22~ G- Sourn•ho.ok of modern traaastor e+icuicc LLaurcnce G. Cowks.. Ebglcwnad. Ct"dfs;. NJ:. :Prcnticc-Hall, c1975. p, cm. Includes indaa•. Bbliography:: p. [TR781L9:C688]. 75-30748' . ISB\0-13-823s~19-1 : 16.95 L Trarrcistor circuits. 1 Title. ' Prepared from CiliP. I .YANNARELLA. Phlip rl: . 016.5'US' f1..A (inrcrnnrar.r .u-i.•ntiLn and' M•hrundp'tiraiier[c~' / he Pliilip A. Yannahdla avd Rm: Alwii )lcun'hciq.N.J. : S:artiinw 1976:. y.. cm. Inchn~•a indnm:. J%'J07.17nJ IQL:B.SI. 75-3X7JU ISI15 UXII18!1/5Xti-9: 10.00'f, Si•i.•rnr-PavLnln;rlr--BrblinerupAr-I:niiln lirtf. t~ hthm 5 J-CornJi wl'-.:Uiblinpf.rP.Sy _• f.ninnYists. 1'C.rnl c.r' f nnmC'nncd Sran~f 4. Amrripn p•riwb?:r1.c-Nrhlinrr.rpSJ'-iiritmhits. !'Aluri. RiutpriN+tnhJr. Jl Ttle. • . Prepared fr.rm C.LI'i • . • K01.11101iF'. li:ra l 547.082 Alaurili ; 1894'r Tinb.w• m aurl,Iricalchrnriapr New 1'ork.. N'iley. Pt. I• vnl. I.I,.csiitcd by I. \11 knl:hmT and Philip 1. Elviu. with the as.nun:e of Lrusai R. Sandul• is now. as ailabtc fbr. 39 ~0. ISG1 O+J 21-J996htr. B.C.card nn.: 59.12J39. - .. JOHNSON;.Rodiwy D•. , , 658.4'03. 1932- . Quantitatire (rrhninucs Bu busir.rs.sdceisinnr L- Rodncy DJulmsoon:. Bcrnard K. Siikin. Englcwood CIIT' N1. : Pr.nti¢-IIhIL..~1976' P. cm. /11D69 UJJ63JJ5-318J5 ISBN 0-1.1-7J6990; X : 13.95 L Daisinn-making-:11a(hcma(ia+JmtN•l.a 1.' .. Oper.ctionsrr.rrarch.~ 2~ Burincrr-Q+L+ pracssinP. I. Si.din, &•mard' R... 1949- joint authnr./! Tirl•. . - Prepared rromiC].P. AGEE, Marvin H., 1931- . 658.4'033. Qruntirarisrana/3xislor msnasenrcnt d.cisionsL hfarv:n H'. Ageo: Robert E. 'fa)lor• Paul E: Torgcrscn. Engl6wood CEOs; N.1.: Prentice-Hall, c1976, p. cm. Includes.h:blioeravliics and indcx.. fHD20.J.A3J 75-38585' ISO?i 0-13•7J6511-FF. c. '2.95 1. brdusttiaAman,agement-:SAthrmmica/'nmdels.. l. Tav/or,. Robert Edn'ar4' joinr authnr. 11.. Torgarsen..PaulE.: jointamhnr 111 Titlc. Prepared from CJ:P. . • IASERspn'trnnnprnf 335.5'd atornsandmu!n•ufes edit.•d by I'J. Ma;nn•r ; with contributinns by'F. A: Blum ... (i•t al). Berlin :\ew 1.uk : SpringerCCrlag. 147j. p. cm. fTopicsin apflied'd phlvo ; s. 21 In:hWa biblinttaphical rcfuumcs aud mdca. 'OC'i51L}k37j 75-3;61aIiBX 0-3X7-073LJX : 38.00 l. lascr spr.lrminpr. ' :Homrc np.:utr.r. ; Sfnlecut.v epr."rm. / IlLther•. /fi rhrrt. Mt;c. 11 Blunx Fred:I.. 111+vPrcparcd frnm C.I.p. HER'fZBERG, Robcrtr 770'.28Edward, 1905- Photo darkrrrrnn guide / by' Robert Iienrberg. 51h cd, Gardcn Ciiy N.Y. : Amphntn• c1975:. 128 p. : ill. ;I20 cm. Origirullj• publlshcd in 1967 by Chiknn Bonk Co:. Philuddphia. fndudcsindce. CTR2X7.114' . 1975J 75-3i2956ISBV 0•8174~11-18•8 :.2.751. Pho+r•araphy--Prorrerfng I.Tr'r@: SIACKEI', Sflchacl C... 5?J.8'7519J:, hrntnI ncryvr rlrnu~h' hir./ueirnl mrnihn. ncs : am imegmted l::cumtical approv:h .' Slii•A:icl C.. \tackcy. 15ahn ; \'ew Ynrk: Springenl`e:lag;. 1975. ca. ]a0 p:: ill.: 25 cn. (I.cclarcnnics.in. Aiomaihamni ; 7) Il hingrnpLy:. g{'2•)].VO. ~Ufi~09.111~ s~3592311 f< pbk.: 10 A J. BLduFt..aPrr.r,+qyrt-3f.r:hrm:niul mn,A•k ~. lferuhianrs /llnL~pJ/-.Ilathcrnatiral rmrJile J; Title. ll. Jcrirs. BRIiCH• rdh"ard.Pranz. 65814 Leopold..ed. 77re princi'rl.•s and prae•tire of nevi,xrcrnenr / edited bt• G., F. L. Itrech. 3d ed. London : New York.: Longman. 1975. 1081 p. : ill. ;.26 cm. Includes index. Bihlingraphy: p. 1067. IIJ31.6733 1901 73•85699ISBN 0-3g2+45039-r • 39.50 r J. Jirdtutrial rnanayrment. 1 Title. • r• a
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W LITERAl"URE BOOKS ENVIRONMENTAL 344'.73'046 ,rStudies' Bwrd Commiuee: on PrimiPlcss of ,' Dccision Making (ar Rcgulating, Chemscalsin ~r the Environment. -I .'- lkridan maling fot rcgulating cAsmicals iir the ' --mcirnnmenl : a repon. I prepared by the - Committoeon Principles of Decision Making ror .. Regulating Chcmiealsin Ihe Enrnonment, . `. Environmental Studies Board. Commission on . C. Natural Resources. National. Research CounciL ., N9shington :Natinnal Academyof Sciences. ~1975: ia, 232p • 23'.cm. Includcs tiiblin8rapIsical references. [KF3958.E5] 75.29655 ISBN 0-309- . B2401-3.p6k.:12.75 - 6 CAemica/t-Law andlegislnion-Unlted .. . bYatex I- Enuimnmcnra/ kw-United States. I• - ' 0'DO\NELL.leery, 1934- . 1 " i ' 510 -Beeinning tn'Lr'nrcnl. nralhercxica / Jcrr>~ O'[Jonncll: Rots•n. Va..: Rcctun Pnb. Gr, c1976W 1 . p rm. Includes index. [QA39.2103] 75 33801 ISBN'..0-87909-074-X:'12-93. .._ . •. l. Ayathcmatics-1961• L- Tilla . Paparcd frum C[.8.. . f •T&E ndio amareurr "~ `: 621.38411 - •Lxsndbook. Newington, Conn.. American Radio Relay League. - - ' Tho-53rd. edition. 1976. by the headquarters staR of the American Radio RclayLeague is'as•ailable for 10.00; 6:00(pbk.) L.C. card no: 41-3345. SIMMONS. Donald M. 5 19.76 A'onlinean pnlema:ming for operanmrs restarch L Donald 51. S;mmnns. L•nglcwood. Cliffs. \.J- v Prenticedlall. <1976, p_ em: ff57.8:555] 75- 37509 ISBh 0-13:623397-R'.: 111.95 . " 1..A'on/innr prrrenmming. C.Title. Prepared from C.I.P... LIiEWELI-1'N. Robcrt W. ' 658.Jf03 Intimnatinn srvrrnc/ Robert W: Lkwrlltn: Englrrr.W('liffi; \.1. ; Prrntice-fialL 0976. p. ' em: Includes hihengmphi,-c ff38.6-L5g) 75- c0223 ISBN 0-I3-~hJtY7-5.; !~AS h ,\f:m.vc.•mrnt inlumanim.qxrcme I Titlr- ` Preparnl frum C.I.P. BATTELLE'Instilute 541'.395 hfaterials'. Science Colloquia. 9th, Gsewd, Switzadand, 1974. • 7Tep h3sital Cssis lvh~•frrucennonc s•'rtiA'sis': Bauellc Institum. \ImerialsS<iens•e. Cnl4iquia, Gsmad, Sriticrland. Sept. 2•6, 197{. r Robert.l: laffee; chairman : edited by Edmund Drauglis.. Roberl I. JiOec. Vew 1'ork: Plenum Press, e1976; p em Includes indesess (0D'-05.037 1974 I. 75 41-f27 ISBN 0.306 3091 b2: 45:00 1. Pimbns Cmr•s.c~c f.HIIce: Rrbsrt Gax,. 19/7+1)- Dnru Hc fdnrnnd. /9i1-lll: BsrlrUe Afemorial lnsritmr.' (irlurnbus. Ohio..1 L" Tirle.. Prepared from C.I.P. •ORGA.VIC cln'tnmir 517.3 t6aprstnl data, )4eu• Ynrk,'1\'ile . LC.eard no.: 60.164:M, Vn!. Il, 1969'[c:I975 rsnuw.acsirshlc fur 42.00, ISO\ 0-471• 63802. . ~ t VOL. 6. Noa 6.. MARCH 19, 1976 WIIC'1111.11\ Llri<h E . 658~.8~ 4Luluint murvs+uenrrm mdlin.vttimal'fitnrs.:' the cmmuour pacLaped gmulc industry /'L'Irich ' E. l5}cchnsmn \cr Yurk : Pmcgcs'. 11176. p,, cos (Pra r r. .pw:d studicain mtcruniunal tunnmms +n 1 ctcrdnpw ntl BibliLtrafl s: p. ' 5.1I5.13 tt c31976]75 1'J831 ISff\. 0-275- . 9/9:1t50 .. N 1. 3J.rrArrinc nxvnan•nrrn6 ?• lntxnatsmal' Au.in.}.. <nr q rr:ec L Tide. .. . ~ . Prep:rrs•d I'r'esu ( .I.1'. 'THEEnalma 574 1'925: . ~~ New-Yurk.Acadamic~Press. - ~ ' The 3rd cd, 1975.. Voll. 122 oxidation-redu,-ri,.n .. rart u, tlectron trannrcr (11) Qxygcnaccs , , Qxidases (f), editcdd bv Paul D. eoccr_ is~ • pn1x yµLL-1lY'rlliX.. L-C. -` card no.: 75-117107. . . . MATIIEAfAT1fAL 6t8.3'01'84 - nJoddin(, for .ater pollufion.conlrnl pnursses / editcdby Thomas Sf. Kcinatli;. Vastin P. Wanielista, .1nm Arbor Ylibls. : Ann Arb'nr. Seicnee Publishers. c1973 riii, 446 p. : ill. ; 24 '. em, . Includes biblingrnphiwl refcrencesand. . Index. ['FD7s5:hf36] 74-14428 ISBN 0-250+ 10077:4 : 20.00 1. Stu:pe-PuriBcatiun-.llnthenruinl mndela' .. L Acinsrh; Thumas.SLN. 11 anirlista. ,11anw P. MODERNlluorescrn:e 543'.085 spectrascapy / edited by E: L Wehry: tiewYork :Plcnum Press.. c1916-p- cm. (hlidcrn analytical chcmistr)) Invludes bibliog raphical references and indexec [QD96'.P56516] 73-13627ISBti 0-306~33903-X (c•.~I) :2150 (v: 1) 1: F7uoresecna•e spcctroscr~py. 1.- Spedtomrtq;: F7uoresccnca.L Ili•bp; E. L, l9l1=' Prepared frcrn CI:P. ~ eVF,THODS in cell 574.g7'01g biolnsJ-. Nen•. York. Arudcmic-0ress. Vol. 12, 1975, isasailabla for28.00. ISBN 0-12- 564112-5. LC. card no.: 64-14230.~ A Biuhopst'sguide. 574.1'92'028'to 1~rincrpk•s' and techniques of prartr.vl' blrk'lIr`rlll.fflN / editcd by Bryan L. B'illiams and; Ktiih Wilsim. \ew York.: American lihesicr Pub. Co., c1975. xxi, 256p. : ill. ;.22 cm. (A .. Srrirsof student Iexts imn contemporary bucd(,•z) f. Title on sPine: Principl<s and teehniquasof' practical bmehumistry. Ir.dudis biblinrmp!,lers and index- [QI'519.7.1356 1975] 74-15516ISBN0 444-19529 7 9.95 1- Biri/nJcalchunlsrrr-Techniqne L. ll'i/lianss:. 8rs.rn 1. O 111/..on, J:birh. 19i6-Ilk Tirle: Prinoiples and techniques of pracnial brA•hemisr.q: , ePROGRtSS in nudeic 574-196arid resevn-h' andd molecu/at br'olncy: h'ew, Ynrk;As•adesnie Press. Vol. 16. 1976, cditrd by Waldo E: Cohn; ua.ailablc for 23.50. ISB9' 0-12-5J0016-0: LC•. card no.: 63-15847;. , I
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• . lfc+. Sprrr.om.r~ Sympo.iow, To Be Ndd , /. Bddum. .. S:XCt . The fimt Inhmzhunnl 8rml.ramm on Qu t', Ivive-0Iwn SPa'tromar' wiil he held at thr Sr.ve - Cnirrmity ofChent,.Andrntimaedreel, YaWera- ' .tnat9, 9000 Ccnt, Brlgium, on Joue:Iy ead.18, IVr'6. Ltu oryanired in mniunaien wilhJhe Inttr- ' Jidv.,5 -neliannlSympoeium'. onAl.v Srycrrometryin Drug Metabalhro ta'.tekc plarain ]lilAn, IWy, . y J40.231076 4.une.. .e1, .., .. ^.{ The O'mpo,ium sitl bede.wtcd to eppliretiaoa .. of qruntiuliwmare ePatrometry. wirh, nupMeie an mtdind, yharmoa•utiral. nnd biorhrmi+al pmh- t 4ms. Plennq` 4rtnrn eoll br Pn.v.m,d hy C, C. - Sw'MIPy, Alrehigea Stare rnireali,r, and II. Adler- 'erente, IInirnaity of.IG6inki.'pao ntLer.ldeanry ; krlurcn hace not yetlbreorhonrn:. -r!••!- A6nnrta nre brine mnyn,.l for nnrrribnlW ' pal'en; whirhnili t:o Lhnitnl tn is mire fur pre- or,tallan- An.orieinnl.:mdS Pixmv.q~in.of enoh '•- aWtmat minP. Ik mlimina1l by frbnmrvI, 10;8, " In Profrx.or Dr. A. 1)n Lrcahnr. l.d.,nuurin eonr - . ~ Slniu~d,r Bi..U.m/r-rn ronr I:Iini.,iie ,1nn11":r•, A.adn u~L %irlrnho Rlil"aunic.a.l4il Conl, - . ~W, Uc~Pin1N:,:m. 11,9000 Cent, ILIv6,m, t t .'-,AOAC ro. Hefd 1976 SpNcr{p'arAr6ep end • ' rrVrrinreen/erenee . ,.. . . ~,! The A®nrintion of OQrGI I Analytical Chemisu -:.tM hnld.rregional Spneg Burkrhopund',Trein- r'lag:Couleretrce ftir 2rfida5a,.Mhy 10-12. 19:6, LL ',the'Exeeulitt Toner len, Deoser,.CO. The aer -.~aiaae are being plnnned to.pmvide expert traioing :; In a eumbr of annlYlinal prohlem errae.ond lo. . dbwparticipation byathndee.: Clyde )i Jonre, Chief Cheminl, Colon,do Deryrtment of Agrieul-. tun,.Denver, ie eoerdiuetinelhe planning.af t6e 1, -7Te Seientifie Pmsnm Commitp.e, ehaieed by =:1Leadore.0. Mr•igtp, hn ucangMithe hi6ouin6 . •; xaiou with thc penon(e) vamrd cnonlinaIing euhaeedon: . .`~w." . (1)'. MycNrmn Aanfyn.-A. E: PahLnd, FDA, W4i DCMd170 nogtbo,t.y 10 m 11. 8:30 ant-: r:89rm; M.y. 1$ 6:90. am-L2:00 noon: fh:NiQ/i~Prewura Ei9aid. Ckrmmtupmpky: ~. ': Pkwro mrd.Anniicn!(one-W: R: Bonto]an; EPA. - I &Ib.ille; MD;. May 10, 6:3e0 onrR30 pm. A'- "iid sperid HPLC couree for enel.auo of pence - farmWetiom.illi be held nt.the Denver Federd -:~:,G`zler fae the 6rat 18: mlurating partieipante. .. '"l"'Cnot.et W.R.Ik:ntcyen /ardetaib (60USN-4"l+b). :(8).6frodudioa /o 6fedrvrh<mimf Anrtlyfind ,, Teehni4vo-R. Oetrn»ung. C^Ibrado Sta1e Cne- rnait,y, Denrcr,CO; blay D, 8:90 em-190 pm. '(QAd Mlinfk CtBd .mnn:a(eay.. :ompner-n.re Daln. AeOpuiline tad ReMM ' Cenemlem-L. -t Hrrnh'leton and It. Collier, Pordue Lniversity, "" . W..LfayeUe, IN; hlny10, 9t00 am,12:80 noon (d'ucr®an) and 1f:0U noon-1:J8pm (Mmon- atnt'iao):.May 11r.8:80 em-4:30 pm (deoromlre- liaa); sad M.y 12, 8:30 arn-12:80 nooo. Lpenil : d:cu.ion). . ' - (3) Statietiee!' TsoAniynee:,Oeneml rheorq.end. APpBcnriane tno the Alnp,.dar. Perlilinr: Check Samyle Pmpmm-E. Clocker. Coneuhirnt, Clenele,. MD;.May 10. 8:70 am-1:20 Vm (Itt'enal themy);, Mey 11, 8:J0 em-1:a0.pm, and May 12. 8:30 am- ~ 12:00.nnon ( Mn6mdm 15o4mm). fe) Jlic!nrwpx-W.C:.Ma{Srone,.MeCrope In-. atfhnc, Cldcago., IL; May 10,.9:p0. am-1::30 pm, , lluethe./uren.ie rie®ti:U; May 11, 9:0pem-8:70 pm(for themvironmcutol xientitQ.. . (7) Aenlyeu o), DrvyRaidaa._,L CDnrey; USDA. Wesldnrtom DC;bfay1p, 8:30 am-1:70 . pm (in nniroal tibua);. C:.E. Juax C,olorado- . DeVarlment.of Aaricnlturq Iknvey.CO; 1luy 11„ 8:30 emi pm (in animd feeda). (A) NWnlioent Annlyeiu n! An::i,nl Pvde- Q W. )i.x.eltia; USDA, Peoria, fl:; May 12,. '8:70.am-12:00nam. ' (0) Pnnicufn/e. .tlntllr Related lu FiBA in -/eed.-7'. M. Drirkry, Jh, nnt~ W. Y:. Eiirntirra; FDA, lt-nxhin6tnn. Dtl;. htay12. 8:30 am-12:00 tooo; For. nddilimuL infurmerionmthe tedminl pm- ' gmm;. mnterl T:.0. hlriRax,. Pronmm Chnitmao, \atinnnl IF6rht Inrniizarinn Crurer, t:P.\, D,•nrer - Fe,lrr.l Cenorr-Roildin6 33. I7enerr;.CD et1a.5 (J6JrxJi-I(ipU. Farr ronmreanations: eon1..1 the. Eateutive Tn.n lon. 1NU6 Cunle St. Drnerr,. CO. SOMQ " 113031571-0.160). R7ir C,.nfemmx arll I,e.ol.e_ Iu anynne riehiee lesUrmL and .uemkve rney dtematr fmm.one. .a.un m anothar if ,hoirnh..Reei.rratinn .ill be 6undi:y Mtemam andevening,d hlay, e. LOb• The ,-lee.illbeS10.00: ' . Chromatography,'76 The 111h International Symposium en Advan•,es in Chroma- . lography will be held November 1.4, 1976, al the.5heraton- - Houstcn Hote/, Houston. Texas. Thescopeof the meeting ' will covcrpapers and iriformal discossienigroups byout- " 8landing researcners from throughout the wedd in all betCs o6.chromatograpny: There.witl also be an exhibition of the IBtest.Ylstrumentalion and books- Participation in the Sym- posium will,be:on the basis ol invited.papers as well as un- g0liciled contribuBons. Authors desiring to.present papers musl: submi1.500+word abstracts by April 1, 1976. The deadlme for receipt of rnanuscriptsof aceepledd paperr is June 1, 1976:.Program and legistralion lorms will.be avail- able in June. All mrrespondence concerning the sympo- grum should be direcled lo Professor A- Zlalkis, Chemislry Departmenl, Universily u/ Houslon, Houston, Texas 77f1(M.
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