Pruhs, D.; Reininghaus, Wolf; Romer, E.; Schnell, P.; Speck, M.; Teredesai, A.
This document is 143 pages long, but the operative information is contained within the first 20 pages or so.
This is yet another scientific report generated for Philip Morris by INBIFO on the effects of secondhand smoke exposure. The date of this report is unclear, but it references another study that was done at INBIFO in 1982, which places it after that date. It also states the date the "test substances" (cigarettes) were received at INBIFO (15 October 1982), placing the report near and after that date. This report, like the others done on this topic, was forwarded to Dr. Ragnar Rylander, who worked on contract to the Philip Morris tobacco company.
In this experiment, one batch of rats were made to breathe various concentrations of secondhand smoke (given in a single "acute exposure" of 7 hours) and other rats were similarly exposed only to ammonia vapor. The objective was to "establish a dose-response relationship for the irritative capacity of sidestream cigarette smoke in comparison to pure ammonia vapor, which is supposed to be 1 of the main irritative factors in sidestream smoke."
The "Conclusions" section of the report states that diluted secondhand tobacco smoke is ten times more irritating than ammonia vapor alone:
"Inhalation of diluted sidestream smoke leads to strong short and long-term irritation...By and large, diluted sidestream smoke is 10 times more irritative than one would predict from its ammonia concentration."
The report concludes that "Ammonia is not the only irritative factor responsible for the relatively (as compared to mainstream smoke) high irritative capacity of sidestream smoke." It obligingly lists a few of the other chemicals in secondhand smoke which may be the cause of this high irritative capacity, specifically formaldehyde and acreolin which "seem to play an important role as far as the irritative capacity of sidestream smoke in concerned."
Page 21 of the report (Bates No. 2501592215) states the "test substances" used. The "cigarette code" is 2R1 and is a "standard reference" cigarette supplied by the Philip Morris. While no brand name is mentioned, the report does state that the 4,600 cigarettes used in the experiment arrived packed in "cartons with 200 cigarettes [of] 10 packages with 20 cigarettes/package," which is the same type of packaging used with their commercial brands.
The report indicates that by 1983 PM was in possession of detailed information describing the higher irritative characteristics of diluted secondhand smoke as compared to mainstream smoke.