Tobacco Documents Online

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Vanguard-a discovery that elimhates the 3 agents cigarettes l/nked to and Heart Diseases: NO Tobacco Tars.-..NO Nicotine, more imporUnt Ar Il C! In the ~ five years l~xhaps you have read articles like: "Cancer by the C,~on", "Csn the Poison in Ci~rerr~es he Av~d~T', "N~ ~ne...~e Smoke~' Enid", ~E~z Ca~ ~-Causin~ ~emi~I Subs~n~ in T~ If ~, you ~ ~ow that t~e is s ~ ~ ~n ~e de~ of ~, h~ ~ ~d ~he i~id~ of lu~ ~. All ~kers, and ~u~rly hm~ ~ok~s, ~ve a ~her mo~li~ ~han non-~ok~ ~ ~en~sm s~ib~ th~ ~ ~e pr~ of ~ba~o ~rs and fine in ci~. Ye~ ~mos~ eve~ ~me one m~i~l author- ky ~blish~ a li~ ~tw~n to~ s~ ~r, or ~n ni~zine and ~rdi~ v~u~ ~) ~iments... another f~ion s~ up and d~ ~he pr~f is no~ ~si~iv~ Bu~ this much ~ ~own for sure: 1. The more you smoke, the ~r~er the probability of your contrac~in~ lung 2. Tob~ ~m ~ve r~uk~ in ~c~ when applied ~ ~n of Shills. 3. Nicofi~ (an albion) is ~ ~bit ~rug. It a~avat~ ~rdiova~ul~r ~ilmen~ (h~ ~fi~). A ~ Canc~-Ca~g A~ent a~u~ ~e ~er of ar~nic in ~bly ~; ~ r~ ~ Y~r ~ recognized as carcinogenic (cancer-e~using) I cork or cellulose.., whether i~'~ a single fllr~er to m~ or a dual filter, or other =ick device~, i~ U~l~ke your present ci~r~reue, Vanguard do anything more than reduce • mere fraction ha~ ab~olumly ~ arsenic. of dangerous substance~ pre~ent in the smoke Fi~ De Not Eliminate Tobacco Tars, of your c~garet-~e. ~qicotfme or Arsenic Three Agents Known To B~ Harmful im No ffl~er on any cigaret~e can protect you Cigarette~ Have Been Taken eomple~ely. Whether that ~ter use~ charcoal Out of Vanguard ! So why rake a chance: Smoke Vanguard and Laboratory Tes~ Prove en~oy pure smoking pleasure un~ainr~d by ~ig~re~ Fatal te Animal~ thee three harmful agents-tobacco ~ but Vanguards Are Not! nicotine and arsenic. The secret of Vanguard (no tobacco tar~ Sixty yo~ug ~lult rat~, evenly divide~l a~ to sex, no nicotine and no arsenic) k "F~ril~" were ~ivi~e~ into ~wo groups. Each ~rroup wa~ i~ in~ravenotmly ~h • f~')~ ~ilu~ion of blended ~ormula of scientifically proce~ed ~ materials (a ~us~er~ion of ~r~pped ~moke natural from Vanguardz ~nd from ~ ~ing ~l~er-zip ci&~ret~e~ Ra~ were obse~wed ~or signs and What's more, Vanguard's amazing fiker ~/mlW~m~ of poi~omng over a period of two dOeS not bare to block ou~ anyzhing. Van- weeks. V~,g,~rd ~ ~light brie~ incr~se followed by g~£rd's tiRer is ~here jtm~ W give you norm~ rs~e of respiration. No o~her signs of clcart, parZicle-free smoke you like. sympton~ o~ poisoning. Le~ling Fil~er Cigarette -- sligh~ brief increase • How does V~ngu~rd ~e? A new, ~ ~ollowed by profound depression and in ~orne in- I clean ~avor. smm~e~ l~-rmanene arrest of re~ph~ion, cysn- ~i~, a~l muscle we~.kness. Onsee of ~ymp~r~ t • Aztd wh~t o~ ir~ aro~a .~ ~t's di~eremL Do~; ~ m@id (within ~ mimne). Anim~l~ th~ f~iled t expe~ a ~tcoo ~x~e./~. Smo~e • pa~k-a wh0~ ~ ,m,,ive died ~urin~ course of injection or wizhim ~ minute of injector, i pack. Give your~lf a chance. Le•dimg Filter Cig&ret~e Vanguard ~ • Remember... it's no~ t;,zt you smoke, i~'~ Do_.._~* ~ Dos.._..~° Mon~ity I w~at you ~rnoke. l.O Z o~ of 10 LO ~one , ~ ~ o.~ of ;0 ~.~ none i • For the first time in your life, smoke ~.o 7 o~ .f ~0 z.o none ~though the to~. effect of cigarette ~,~oke c~n. i • Smoke Vanguard. m~ ke ~m~ exxr~pol~ ~o man, it m~t ~ ~ _~ • moke ~ citrate, contain* ~u~mg W~t~a g~ter ~tential toxicity Z~n ~ *p~l~,~d ~t~O~, ,~rvey, ~ ~ ~ s~ *f V~ar~ with ~ri~s ~en~ ' ~~l~r~A~~w~ ~n. O~a~ Dr~v*. ~aysbere. ~ I~ New Y~r~

Cancer Society Applauds Vanguar : (.finley. ho~pi~ and pa~i~-n~ ~u~erin~ c~nc~r, e~rdio-v~u~af and Brigh~'s d~'~' wired and phon~ ~he manufacturers o~ Van- At that time .Xlr. MeF.ord IL Runyan, Ex~cu- Vsce-Presldent o~ the ~eHc~ Cancer ~- c~ety issu~ ~he fvHowln{ sta~men~: "~e American Cancer S~[ety ~lieves t~at smoking of ci~arett~ ~ ~he chief caur~ ~or ~!arming r~ in ]un~ caner tn Lhe last ~wen~y year~ The Vang,Jz., : ~n h~*.eres:ing reflection of the Public's cone: .... ,'er smoking the familiar tobacco cigarette..~:~,--~pts to produce a smoke are to be ~ ;r~ " ,¢ , ".'ed. However. it will not be possible to mak~ .,,. cstlma~e of the s~fety of +,his or ~ny other .... ~ ",,noking product without extensive observa~:''" ~'~ +.ests.'"

~v~on ~he ~ day, and ~he nex~ ~ch w~s gone Lhe ~nd ~o~ "~ ~b~e ~ ~'~t~ " :~ one ~l~ ~ a~t ~ ~o r~lMe for ~ad-~w~d salty ~ ~u~m~ of w~k. He ~y, ~at ear~n p~ have ~c'n hea~ "in-~,~e~ at~m~t ~ d~ a ~m-~f~t u~ ~ ~h *~elo~t ~e~t~ ~e~ y~ leave v~- Ban~b h~ a~u~M a ~,~re f~t pXant Bay Sho~, N.Y., which once w~ o~r~d by a ~bacco ~n- a r~ for ~ ~n~t~: "~ C~a-Coh te~l Business Week r. YoUr "~an~ar~ £~s far ~vond the various ~e-n~tln~ ~ divulge what it d~ ~n~in." "B~n~b ~on~ an inde~ndent rose.oh agency ¢~ ~rld't to~ ~. r~ t~ pmuct ~mou~n a rat test. zne agen~ ~ven out ~f la ra~- di~ Cr~ ~- ~,,;x.~*~-, ~ ....... ¢ n~,.. sa~ oc va~ ~~ ~i s~ ~), ~£ ~ ~ ~- ,~ ~ of t~ ~t I He "s e to b y V gu d re er u an ar . . ~ Food Fair. Safew~y - ~ck - ~- K~ Ku~ - ht~~-~~'s-Pe~ ~v~-~-Key ~-~ ~ ~ ~ - T~ C~. ~s. Wake~. ~~. ~ ~- ~y~ ~~ ~ ~ o~ ~I ~

January 6, ~966 Dr. W. M. Bright Re: A Process for the Elimination of Carcinogenic Properties of 3:4 - benzo - pyren in Cigarette Tobacco" An application for a German patent on the above process has been registered at the Geman Patent Office, Munich, Germany, under the number B 82 871 IV a/79c. The inventor is Dr. Max Bindlg. He has done research on cancer and is the Chief Hedlcal Doctor of the Medlcal Institute "Perclval- . Pott-Statlon" in Munich, Germany. In the practice of the invention, t~o pounds of an organic substance (unidentified) is added to about 333,000 grams of tobacco for manufacture into cigarettes (rate of application is about 0.3Z). As reported in Tabacologia 18 (No. 9) 25 (1962) aroma of the tobacco (presumably aroma of smoke upon smoking the tobacco) is not affected. It is claimed that the presence of the organic substance in the tobacco prevents the formation of 3,4-benzpyrene (same as 3:4 - benzo - pyren) during smoking. It is conceivable that the above conclusion may have been reached in good faith by the inventor with the analytical method he had available when his experiments were conducted. However, if the experiment and the analysis were repeated by us at this time, it is believed that only a moderate reduction, if any, of 3,4-benzpyrene would be observed. The following factorshave been considered in coming to this conclusion: I. Analytical Metho~ Considerable work has been done both here and in Europe on the development of a reli.able ~nalytical procedure for 3,4-benzpyrene in cigarette smoke. To our knowledge, all methods in use, as late as about six months ago have been extremely cumbersome and time consuming. Host of the methods rec the smoking of about 3,000 cigarettes and in no case less than 100 ci Accuracy of any of the methods was unsatisfactory. For exsmple, analysis may have showed a yield of 3,4-benzpyrene of 3 pg/100 cigarettes on one lot and 1.5 pg/100 cigarettes on a subsequent lot of cigarettes in the same experiment. It is conceivable that in making the analyses for Dr. Biudi~, the analyst might have obtained the value of 1.5 pg/lO0 cigarettes on the control and 0 pg/100 cigarettes on the test, whereas the actual values should have b~en 3 pg and 1.5 pg respectively. Nonetheless, Dr. Bindig could have logically concluded that the 3,4-benzpyrene had been eliminated. In no case have we been able to completely eliminate the 3,4-benzpyrene in our experiments with additives. We contend that many of the exaggerated claims which have been made by various investigators regarding reduction of 3,4-benzpyrene are attributable to unreliable analytical procedures. 2. Types of Additives None of the organic additives has reduced 3,4-benzpyrene in our experiments. Reduction has been achieved with inorganic additives, but never complete elimination. Three types of inorganlc additives are discussed below.

2 Classes of Inorganic Additives (a) Oxidizing Agents Cupric nitrate, potassium nitrate, magnesimnnitrate, aluminum perchlorate and others, have reduced 3,4-benzpyrene and other polycyclic hydrocarbons. However, the nitrates resulted in formation of toxic oxides of nitrogen. These additives are therefore deemed undesirable. (b) Sulfam£c Acid and Anmonlum Sulf~mate Moderate reduction of 3,4-benzpyrene has been achieved by the addition of these materials; however, flavor of smoke is adversely affected. (c) Aluminum Oxide Trihydrate The addition of 25Z by weight of the above reduces 3,4-benzpyrene by about 25Z. Reduction is attributable to lowering of burning temperature. It is believed that formation of 3,4-benzpyrene is one of the fundamental reactions in the smoking process. The prevention of formation of the material would therefore require a very substantial change in the smoking process. It is highly unlikely that this change can be brought about by an organic substance. I have discussed the patent with Dr. Teague,~He w~"~ot able to envisage an organic material that would reduce 3,4-benzpyrene in smoke. Extraction Procedures 3,4-Benzpyrene in smoke has been reduced by extraction of tobacco prior to smoking. The extraction (with hexane, ether, chloroform) removes long-chaln aliphatlc hydrocarbons (C15 through C33), sterols and solanesol, which are believed to be the main precursors of 3,4-benzpyrene. The mechanism of formation of 3,4-benzpyrene fro~ these precursors.ls believed to be a series of cyclizations, dealkylations and dehydrogenations. One would expect that oxidizing agents (i.e. KN03, and others) would affect these reactions. The effect of the anmoni~m sulfamate is obscure although i~could act as a burning retardant. A lowering of the burning temperature would be expected to affect these reactions and it is not surprising therefore to find that al~nina trihydrate reduces 3,4-benzpyrene. However, it is difficult to vis- ualize how an organic substance could affect these reactions. In v~ew of the above, I seriously question the validity of the Bindig patent and do not reconmend that we express any interest in it. Horeover, it should be recognized that the presence of a substantial smount of a foreign organic material in tobacco (0.3~) would likely produce appreciable amounts of new smoke components which might possess undesirable physiological properties.

The cancer researcher and chie£ medkcal do, cot o~ the medical institute "P.ercival-Pott-$tacion" l~unich, Germany has developed a:method which makes . it possible to render benzpyrene~ the cancer producing substance in tobacco,.+ =ed~cal.c'ongress (unknown) and in addition told ~s ~o~e detail~ during an Sn~crview £u Hunich. Accordiu$~y, through chemical and technical method~ possible to el~ninate the cancer producing benzpy~ene. Dr. Biudig . ~old us that a method has been developed in the Hun£ch institute £u ~h£ch ~hey eliminate thi~ danger through structural modification of t~e benzpyrene, the aroma o£ the tobacco £~ in no way ln£1ueneed., 12130/65

M E M 0 R A N D U M This memoraudum relates briefly the past hlstoryoof the ne -' got~atlons which were carried, forward over a period of three~ months between, BARON MAXIMILIAN DE CLARA,Mr. LOUIS BECK and Associates on the one (US) hand" and GLOBE-MONTAN G.m.b.H. on the other (German) hand. These negotiations were exclusively concerned wit.h the purchase . of the world rights (exclusive of West-Germany) for a new German invention registered at the German Paten't Office (Munlch,Germany). under the number B 82 871 IV a / 79. c in respect to " A process for the elimination of the carcinogenic properties of 3:4 benzo pyren in clgarettetobacco." These ne~otlations were successfully concluded on November 18th, 1965: . • ' H~Is~ory: .During Summer of 1965 Baron de Clara was made aware of the' - •existence of the new German process by one of the partners • ..... of GLOBE-MONTAN G.m.b.H. Baron de Clara subsequently in - ' • .i.~. . formed Mr. Louis Beck of the" developments and it was then .. .... :-':. . decided considering the importance of the new Invention ." if it checked out right to open negotiations for the ..... '. purchase of the world rights exclusive of West-Germany.. : • . " A considerable amount of valuable information was sub - .. ~ . sequently forwarded by GLO=~E-.MONTAN~.G,~t~h.H~. ~o~New ~ork which removed practically any doubt.the US-Group m~ght " ~-- ~ have had regaling the valldit~ of the German claims as .... . to the efficiency and economy of the new. process.It was'. .. therefore• ~eclded by the US-Group to..go to Germany to flnal'Ize-the negotiations on the spot. ., US-Group: Mr. Louis Beck,Baron Maximilian de Clara,Mr.D. Thomas, . .,, Mr. Charles Roche and Mr.. D. Halperin. .... . Mr. Louis Beck ~. Mr. Beck is an attorney-at-law with off~ ~t • " " .-. ~ .... ~..515 Madison Avenue,New York City,N.Y.He "~ ~ne . ,. • :-~.~:;..".~.. treasurer of the Democratic Party of the State . '~~ . .~ ~~..~.::. ~..~".: ..",~..:: of New York and a member of the ~esldent's Club, ,.-. -" .~ ~: ".~>~:~..In Washin~ton,D.C.Ee has been highly reco~ended : ..~'... • ". " "-...~. by the Vice-President-of the USA,H.Humphrey,(see ...>....:. ~;.~ letter of Mr. H~phrey to the US-~bassador McGhee . .-...: according to wire information received from the ~' :.'"" :. ~ .... ~a~lin National ~ is In the medl/~ seven . . ~ron,Eaxlmillan,,~e'~ Clar~:. Baron de Clara Is. ~ officer and director " ' ....... """.. ~>.~Ge~n:to~coo deaI'was tha~ of a."Finder"