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Anne Landman's Collection

Nicotine Patch Overview

Date: 19920400/DE
Length: 18 pages
2025497103-2025497120
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Abstract

By 1992 it was well established that cigarettes kill consumers. Yet even in face of conclusive evidence that its consumers were quite likely to suffer cruel and suffocating deaths, the Philip Morris Tobacco Company (PM) didn't want smokers to quit.

By 1992 a number of nicotine replacement therapies had entered the market. PM was clearly threatened by these "competitor" products which as they put it, would "accelerate decline of the cigarette industry" by "enhanc[ing] the success rate of quitters who permanently leave smoking." Moreover, PM kept track of what they termed the "Gross Industry Smoker Loss" they incurred due to the nicotine replacement products coming onto the market.

PM's recent advertisements portray the company as socially responsible: feeding the hungry, providing safe water to flood victims, supporting victims of domestic violence, helping educate the disadvantaged, etc. Perhaps a truly socially conscious company, however, would be just a little bit more receptive to the plight of their own consumers, the millions of addicted smokers out there who are desperately seeking ways to quit smoking and avert an early death?

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Nicotine Patch Overview

[from page two of the document]

CURRENT PERFORMANCE • Nicotine patch sales have exceeded initial expectations. 1992 estimated sales $600 - $800 million with some predicting results close to $880 million. 1993 figures to be $1 billion. • Strong demand fueled in part by heavy ad spending featuring TV and print. Magazine only spending was $18.5 million for category with about $3-$5 million for TV in January - March 1992. • Patch orders outstripping current capacity prompting plant expansion, new machine installation. • Profit margins estimated at 15% after taxes - roughly in line with cigarette industry. • Patch treatment per quitter is approximately $350.00.

[from page four of the document:] PATCH EFFECTIVENESS • Consumer endorsement high with 88% who would recommend to a friend. • Initial clinical results indicate that the nicotine patch was somewhat more effective against placebos. Success rates for nicotine patch 17%-36% vs placebos at 4%-26% in impacting smoking abstinence. • Some sort of behavior modification was administered during the clinical tests. ~Without some degree of psychological therapy, many experts warn that the nicotine patch is powerless. • Nicotine gum achieved comparable results visa vis placebos. Yet, treatment is often demanding. • Up to 30 sticks/day • Very gradual dose reduction • Required to keep product between cheek and gum

[from page 12 of the document]

IMPACT ON QUITTING

* Approximately 23% or 11.7 million smokers try to quit every year. 3.5 million claim to quit in the past year. 2.4 million stay quit for the year. * Nicotine patch could potentially accelerate decline of cigarette industry in several ways:

o Encourage more smokers to try to quit o Enable more triers to actually quit o Enhance success rate of quitters who permanently leave smoking

1992 QUITTING OVERVIEW [from page 18 of the document]

1992 QUITTING OVERVIEW Smokers (millions)

[chart contains information describing the millions of smokers who tried to quit in the past year, claimed to quit in the past year and "Gross industry Smoker Loss"

Company
Philip Morris - (soon to be known as Altria Group)
Author
Corporate Author Philip Morris (presumed)
Recipient
Philip Morris
Region
United States
Litigation
Stmn/Produced
Named Organization
Alza
American Cyanamid
Ciba Geigy
Cygnos Therapeutic
Elan
FDA, Food and Drug Administration
Kabi Pharmacia
Marion Merrell Dow
Roper, Roper Org
Warner Lambert
Type
SPCH, SPEECH, PRESENTATION
CHAR, CHART, GRAPH, TABLE, MAPS
Subject
nicotine patch
quitting

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Page 1: gmz88e00
NICOTINE PATCH OVERVIEW eoi4svszoz
Page 2: gmz88e00
CURRENT PERFORMANCE • Nicotine patch sales have exceeded initial expectations. 1992 estimated sales $600 - $800 million with some predicting results close to $880 million. 1993 figures to be $1 billion. • Strong demand fueled in part by heavy ad spending featuring TV and print. Magazine only spending was $18.5 million for category with about $3-$5 million for TV in January - March 1992. • Patch orders outstripping current capacity prompting plant expansion, new machine installation. • Profit margins estimated at 15% after taxes - roughly in line with cigarette industry. • Patch treatment per quitter is approximately $350.00. tdT4GVSZOz
Page 3: gmz88e00
COMpETITION • Habitrol • Ciba Geigy • 60% SOM * FDA approval 9/27/91 • Nicoderm • Alza/Marion Merrel Dow • 27% SOM • FDA approval 9/18/91 • Prostep • Elan/American Cyanimide • 13% SOM • FDA approval 1/28/92 • Nicotrol • Kabi Pharmacia/Warner Lambert/ Cygnos Therapeutic • Not in market SUTL6VSZOZ
Page 4: gmz88e00
PATCH EFFECTIVENESS • Consumer endorsement high with 88% who would recommend to a friend. • Initial clinical results indicate that the nicotine patch was somewhat more effective against placebos. Success rates for nicotine patch 17%-36% vs placebos at 4%-26% in impacting smoking abstinence. • Some sort of behavior modification was administered during the clinical tests. Without some degree of psychological therapy, many experts warn that the nicotine patch is powerless. • Nicotine gum achieved comparable results vis a vis placebos. Yet, treatment is often demanding. • Up to 30 sticks/day • Very gradual dose reduction • Required to keep product between cheek and gum 9nT46tszoz
Page 5: gmz88e00
40 35 c 25 J W Z_ 15 ~ 0 U 10 z - D.- I- o Cigarette' * 2 mg nicotine gums 0 2 I I I 4 6 8 TIME (min) L I0 12 W,
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2a25497108 r 20 HABITROL PATCH m V 5 0 . 0 0 10 . 20 IN . 30
Page 7: gmz88e00
185z 165 CigarE tte Plnsma nicotine ( nrnof/1) 145- y 125- 105~ 85~ . 65' 45-1 , 0 }0 . n" 2C 30 40 .50 f 0 T i:. e ( rnin ) NNS t Cigarette Nicotne gum l Avcral,e plasma nicotine conccntrationa of three suEyects after smokinr-a - ci~arcttc, takins~. nasal nicotinc solution (NNS), an.d chcw-ing nicotine gum. i)oscs of nicotine were 2 mg for nasaI nicotine solution and nicotine Fum ancl zvcris~cd 1•97 n:g (sce tcxt) for the cigarettc. Convcrsiorr:.. St :a trocliriarrnl ur.its--tiirntinc : I ntnal/1.;; U• 16 nglml.
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PATCH CLINICAL RESULTS Post Treatment Behavioral Objectively Patch Brand Duration % Abstain Therapy Validated Patch Placebo Habitrol 3 months 36 23 Yes No Nicoderm 6 months 31 8 Yes No Nicotrol* 1 year 17 4 Yes Yes Prostep *16 hour patch 1 year 26 26 Yes Yes ntZLGtSZOz
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POLACRILEX (NICOTINE GUM) CLINICAL RESULTS Post treatment Objectively Dose Tar et Duration % Abstain Validated Gum Placebo 2mg Low nicotine dependent 1 year 40 24 Yes 4mg High nicotine dependent 1 year 44 12 Yes t IY46bSZOz
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METHOD USED TO QUIT SMOKING PAST 3 MONTH QUITTERS Stopped All At Once Nicotine Patch Stopped Gradually Nicotine Gum Stopped Smoking Class Hypnosis SOURCE: Smoker Tracking Study 85 ® Jan/Feb , April ~ May z TzLsVszoz

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