Industry-Provided Depositions
Project 6900 Physiological Studies (Semi Annual)
Abstract
Project 6900, Physiological Studies. Reports results of several sets of animal studies, examining effect of smoke inhalation and of skin painting. Finds, in primate inhalation study, that only two of the smoking monkeys survived, and that the others are pressured to have died from carbon monoxide poisoning, which was found to be in high saturation in the surviving animals; notes monkeys smoked 35 cigarettes per day for nine months, the equivalent of 30 packs per day for a man.
Fields
- Notes
Original document code was 2958.
- Minor Subject
- Cigarette -additives
- Health and Medical Research -animal studies
- Health and Medical Research -diseases and conditions --cancer ---lung
- Health and Medical Research -diseases and conditions --respiratory disease ---chronic bronchitis
- Health and Medical Research -diseases and conditions --respiratory disease --emphysema
- Product -testing
- Tar
- Tobacco Industry -research
- Health and Medical Research -animal studies
- Site
- Minnesota litigation
- Author
- Type
- Chart/Graph
- Report- Scientific
- Major Subject
- Health and Medical Research
- Product
Document Images
TKBLE iIl
Brand
Ma~r~boro 85
Commander
PhS!ip Morris Filter
Tr~p,!e Filter
Mean Reduction in
Respiratory Rate
25.891 ~
~. ~4~ L
12.297~
Two, meansv~-i~o~'~--~ in, the same bracket are
not s~gnificantly differen,t from each other
a~t %he 5~$ level.
- I0 -
TABLE IV
Treatment
]oncentration
Mean
Variance
Pyrene
I" '
o o.I O.oll
12.066.1311.2]
13.355.6 26.~8
0.001
L6.19
Skin Thickness (arbitrary scale)
Urethane
15.117.945.122.74
Methylcholan~hrent
0 0.I 0.010.001
8.0! 7.7('6.0i6.95
4.2
4,4~
0.71
o.1
4.513.7 .84
2.7fio.413.93
B(a) P
o O.l o.o~o.oot
~.i~ 18,61~.359.47
I. 92 ~9.0"141 1.5~.. 67
Diemthyl-
nitrosamine *
o o.I o.o1D,oo]
7,2:7.358.1~7.75
I. 6~ 2. 684.0f~3.16
Sebacious Glands ~number
Treatment
Concentration
%
Mean
Variance
0 0,1
6.885.26
1.711.33
Py~ene
0,0] 0,00
1.88 3.15
1.3~ i.78
Urethane
0
1.75
0.I
6.7(
2.2(
Me thylcholanthr en~i
*
~..O!O,OO] o o.1 o.o~lo.9q..~ o
6.38'5.88 .i~0.26.9.2:8.7([~.71 5.89
1.18[.79 4.931. i~ 1.8_~i.00 1.02,
B(a)P
o.1
6.225.7~5.92
[.35,3.910.77
B(a)~
0 O.E 0.010.00t;
8.831 8.458.2~7.80
"
Dime£hyl,
nitrosam~ne *
0 O. 1 ~0.01
2.3~1.9~5.78
3.001
7.77
1.8~
* = False negative
Group
Control
M
d~
TABLE V
Skin Thickness
Treatments
Uns tretched
Treatments
Stretched
2 applications .~ applicatio~ 2 applications
8.08 : 7.34 7.33 8.60 3.98 5.66 4,77
.12 .47 .12 .25 .59 1.53 1.21
18.17 15.99 7.07
9.79 10.78 12,96
7.94 ]0.02 4.19
• 42 .98 .2~
7,43 8. ~ 5,50
.20 .86 .73
1 application
3.85
.17
4.47
.51
4.92
.91
3.90
.29
Number of Sebaceous Glands
Treatments
Unstretched
Treatments
Stretched
2 applications i application 2 applications 1
application
Grou~
Control M 6.81
~e .21
6,76 6,76 7.35
.29 .29 .42
3.66 4.10
1.17 1.82
6.82 6.66
1.0~ .06
6.55 6.10
.i0 .06
- 12 -
mean value
variance of mean value
5.32 5.62 6.36 6.12
.14 .59 .25 .83
3.39 4.18
.61 ,82
5,73 5.74
.26 .ii
6.28 6.52
.06 1.35
Physiological Studies
Luchs inger
996
DATE LOANED
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