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CJP/JP/4BM 31stOctobe~ 1988 A PRESENTATION BY ARIA GREEN'S RESTAURANT, LONDON 25THOCTOBER 1988 Author: C.Jo Proctor T PUrl~ose of Meeting As far as we can gather, the purpose of this meeting was to Inform the UK industry about the Philip Morris Initiative of setting up a group of scientists tn the UK that will comment on ETS Issues. That the meeting was designed to cull financial SUppOrt was denied, though it was made clear that contributions would be accepted. Attendees BAT (Dr. Boyse and myself), Gallaher (Neimes), Rothmans (Frost and Brown) and Imperial (Sadler and another) all sent representatives. R.J. Reynolds had some five members present, three from the US, two from Germany (several of these having worked on the toxicological side of the Premier development). Galsch (PH), as sponsor, also attended, as did Charles Lister (Covington and Burllng)o ARIA ARIA is the Association for Research on Indoor Air. Its principal members are Francis Roe, George Leslie and Frank Luneu, each of whom gave a short presentation prior to dinner. R_~ defined the purpose and structure of ARIA and Introduced Leslie as a toxicologist and Lunau as an occupational hygienist. He stressed at length that the t6 Individuals currently operating for ARIA were totally independent and that there was to be no formal contact between the individuals (not to be termed consultants) and the industry. C~ C~ ~0 J~ Oo BATCo document for Legal Services • Health Canada 1 December 2000

F T Leslie Is the co-ordinator of ARIA. other PM Initiatives. The structure at present is: He described how ARIA fitted into Zndustry (PM) Covington + Burltng Nordic Centre for ARZA Canada France + Others Environmental to be Health and 0rganised Human Toxicology (Schwartz e¢ at., US) The French group, to consist of around ten members, is practically In place. It was suggested that the position of Covington and Burlington allows the members of each group to remain independent of the industry, though all know that it is tobacco money that is funding the exercise. The 16 members of ARIA have been selected from many scientific disciplines, though there Is still an absence of a clinical SDokesPerson. Their role Is to be active In learned societies, to attend relevant meetings as observers or contributors and to provide reports on Interesting papers (though primarily for circulation within ARIA). Leslie would not Identify any of the members of ARIA apart from those present. The group are still very much In a learning phase and the only real activity at present Is the production of two books - one on Indoor Air Quality and one on ETS (based on dosimetry and social Issues). (Incidentally, Leslie said the IAQ book was so good that they could readily choose their publishers.) Apart from this, the group will continue to meet twice a year, dates of 9-1Oth March 1989 (Broadway) and September 1989 (Touraine, France, where the French group will also attend) being planned. These meetings are multi-disciplinary and are closed. It Is still being discussed as to whether the Group will undertake some research (as might be suggested by their title), but Roe suggested that much of what would be useful would be large, long-term end expensive. It was also emphasissd that the Group was not designed such that its members would act as exl~ert witnesses, Luneu has some input Into the British Occupational Hygienists' Society and will be involved in a special Interest group of that Society on IAQ. This may be useful if discussions lead to European standards for ventilation after 1992, particularly since French restrictions on public smoking are heavily based upon whether a particular environment has adecluate ventilation, C~ ~O J~ "O BATCo document for Legal Services • Health Canada 1 December 2000

Conclusions Z believe that the concept of a multi-disciplinary group that can "speak up" In learned societies or at meetings Is a good one. However, neither Leslie nor Lunau Inspire me with any particular confidence that the concept will have serious impact In the next few years. Horeover, this meeting was more of a statement of work rather than a progress rel~or¢. C.J. PROCTOR J:b C3 C~ ~O J~ 0 BATCo document for Legal Services • Health Canada 1 December 2000

B.A.T {U.K. and Export} Limited RESEARCH It, DEVELOPMENT CENTRE SO~TH AUPTON ENGLAND TO Mr. A.L Heard Millbank ~F PDCKJW46M FROM Mr. P.D. Case DATE 24th October 1988 Sidestream/ETS_ Subje_(;tive Characteristics of UItm Sllm Products r Alan, Sometime ago you asked for comments on our intemal work on the sidostream and ETS subjective assessment of Capri against Marlboro Box, Doral Lights and Virginia Slims and how this related to the work reported by Professor Cain. Essentially the R&D work was carried out in both cubicles and rooms in a paired comparison mode. In the room studies subjects were asked to comment on the pemeived subjective characteristics at both 30 seconds and 5 minutes after being brought in contact with the smoke, whilst the cubicle assessment is made after 30 seconds. You have previously been sent all the individual scores from these tests, and in the table appended the tests are recorded along with the number of subjective parameters that are statistically lower for Capri at the 95% confidence level or better. In terms of Cain's work I strongly suspect, due to his single room facility, that the results are based upon monadic evaluation. However he does make the following statement (relating to the subjective parameters assessed) in his draft paper which again I believe you have "Nevertheless, one trend stood out; the ultraslim brand Capri consistently fell below the others at both rates of smoking'. However there is no way of assessing on the basis of the data submitted in his paper as to whether or not the differences between Capri and the other brands are statistically signilicanlly different. I have checked with Bill Deines if any further data analysis has been carried out by Cain on the raw data used in his draft paper, essentially none has been done and none has been requested. P D Case cc" Mr K.J.H. MacLean Dr. T. Hirji Mr. J.A. Luke C~ P.,. Lrl BATCo document for Legal Services : Health Canada 1 December 2000

STATISTICAL,LY ~IGNI~CANT DIFF_F__E_R_I~NCES BETWEEN CAPRi AND 3 OTHER _ • ,UFPRODUqTS NATURE OF TEST ....... Capri vs Marlboro Box : Cubicle Capri vs Madboro Box : Room 30 secs Capd vs Marlboro Box : Room 5 rains Capfl vs Virginia Slims : Cubicle Capri vs Virginia Slims : Room 30 secs Capri vs Virginia Slims : Room 5 rains Capd v~ Dotal Lights : Cubicle Capri vs Dorai Lights : Room 30 secs Capri vs Ooral Lights : Room 5 mfns NUMBER OF PARAMETERS STATISTICALLY LOWER FOR CAPRI 8 out of 8 3 out of 8 3 out of 8 6 out of 8 6 out of 8 6 out of 8 5 out of 8 3 out of 8 4 out of 8 J~ C3 ,,43 U~ Crl P~ BATCo document for Legal Services : Health Canada 1 December 2000