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among brands varied somewhat with attribute (cf. eye vs nose irritation). Nevertheless, one trend stood out; the ultraslim brand "- Capri consistently fell below the others at both rates of smoking. Within a brand, the attributes of eye irritation and throat irritation consistently had approximately the same intensity, whereas nose irritation and odor had higher intensity. This pattern held true across brands, even though the absolute differed (see Figs. 7 to10). The averages shown in the figures fail to depict the dynamic nature of the irritation and odor responses. Figure 11 displays eye irritation from Capri and Dotal over the 3-rain periods of judging when the smoking rate equalled 10 cig per hr. Two trends emerged: 1) irritation increased over the 3 rain of exposure, and 2) irritation increased from round to round with the larger increase occurring from the first to the second round. Figures 12 through 16 reveal that the same trend held for Marlboro and Virginia Slims and for nose and throat irritation as well as for eye irritation. Odor intensity showed less of a tendency to increase over the 3 rain of exposure, but still tended to increase from round to round (Figs. 17 and 18). ~.; What held for the smoking rate of 10 cig per hr also generally held for the rate of 15 cig per hr, though somewhat less uniformly (Figs. 19 to 26). The data at 15 cig per hr departed from monotonicity more frequently, but still encouraged the conc!usion that irritation and odor increased over time both within and between rounds. The increases in irritation and odor during and between rounds of judging most likely represented the action of two processes, one sensory and one physical. The tendency for irritation to increase over time during continuous exposures to low level irritants is well established as a property of the common chemical sense (Cometto- Muniz and Cain, 1984; Cain eta]., 1986; Cain et ai., 1987). We can accordingly attribute the increases during a round to this process. The finding that increases in odor were less prominent and systematic reinforces such a conclusion. The increases across rounds, however, may require a physical explanation. Although we had anticipated that the gaseous constituents would have reached steady state after an hour, small increases generally continued to occur thereafter. Such increases, despite their small size, mw have led to the round-to-round increments in c23 Q tj1 U'l P~ co cr~ ClibPDF - www.fastio.com

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Z'.1.gur e 12 I81 EYE - Marlboro I0 clg/hr 16 $ ~2 . '2 0 1 2 3 t;me (mtn) -~ uuxll -" zud2 16" 15" 14" m c m I¢ l 12- Ii 0 EYE- Virginia Sllms 10 cig/hr 1 2 3 time (rain) -.- mun£2 -a- zoun~ :! amm, h C~ u'l -,< ClibPDF - V'G',J'JVV.fas~[io.coI]]