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i ° TOBACCO RESEARCH Telephone : O1 - 828 20-1.1 TelccJrams: l~bcom.London, 5.W~. 1. COUNCIL G|¢n House. S~acj }'lace, London, S.W, 1. CONFIDE NTIAL Dr. R. Comber. 16th February, 1971. /I ,1 Dear Sir, S.B.S.G. Letter No. 148 I have pleasure tn enclosing copies of the following papers :- Application for an extension of their Research Grant from Dr. A.E. Williams and Prof. H. Smith of the University of Birmingham (J 203) o Progress Report for the period June 1970 - December 1970 from Miss Diana S, Davis and Dr. A.E. Williams (J 204). , Addition to the Hyperplasia Progress Report from Dr. R.F. Davies (J 21,1). Yours faithfully, D.H. Beese, Secretary. Encs. ~XD ~O

% TOBACCO RESEARCH Telephone: O1-828 2041 Telz ~eams: Tobcom. I.ondon. S.W. 1. CONFIDENTIAL Dr. H. Comber, COUNCIL Glen Hous~. S)ng Placc, London 0 S.%V, t. 4th February, 1971. f Dear Sir, S. B. S.G. Letter No. 147 Combined S. B. S. G./S. M. S.G. Meeting I should like to confirm that the combined meeting arranged for 10th February has been cancelled. Next S. B.S.G. Meeting The next S.B.S.G. meeting will be at 11 a.m. on Tuesday, 9flt February at Glen House. Luncheon will be available. The following papers are enclosed for consideration at the meeting :- , 2. Age nda Item Agenda (J 174) p Paper by P.N. Lee and J.A. O'Neill on the effect both of time and of dose applied on the turnout incidence rate in skin ~l~JntJng experiments with Benzypyrene (J 173). 4 (n Yours faithfully, D.H. Beese, Secretary. E ncs. CD CD

I L TOBACCO RESEARCH Te.]e-phone : Ol" 82B 2041 Tzlegr~ms: Tobcom.London, 5.W'.I. COUNCIL Glen House. Slug Place. London, SAV. I. CONFIDENTIAL Dr. R. Comber 2rid February, 1971. Dear Sir, S. B. S.G. Letter No. 146 Next Meeting The next meeting of the Skin Bio-Assay Study Group will be at 11 a.m. on Tuesday, 9th February at Glen House. Luncheon will be available. An Agenda for the meeting wiU be circu.lated later. Copies of the following papers are enclosed for consideration:- . 2. Harrogate Hyperplasia Progress Report, February 1971 (J 130) Harrogate Tlssue Culture Progress Report, February 1971 (J 131) 3. Final Analysis of Experiment 1. I. 7.4. (J 151) / Encs. Yours faithfully, D.H. Beese, Secretary. CZD cZD cZZ) J

• o TOBACCO RESEARCH Telrpho.e : 01- 828 2041 "Felzgz.am.1: Tobcom.London. S~.I. CONFIDENTIAL Dr. R. Comber. COUNCIL Glen House, Slog Place. London. S.'V~: 1. 18th December, 1970. Dear Sir, Next Meeting S.B.S.G. Letter No. 145 I should like to confirm that the meeting arranged for 12th January, has been cancelled. There will be a meeting of the S. B. S.G. on Tuesday, 9th February at 11 a.m., and ou Wednesday, 10th February at 11 a.m. a combined meeting of the S. B.S.G. and S. M. S.G. Paper for information : Analysis of Harrogate I.C.I. mouse experiments by four-methods. (H 1698). Yours faithfully, D.H. Beese, Secretary. Enc. O F~

• TOBACCO RESEARCH. "re~pho.c : Ol - 828 2041 "l'elcgr.m~: Tobcom. Lol*do.. 5)A:l COUNCIL Glcn }lou.-¢c, Stag l'lacc. London. Sit" I. CONFIDENTIAL Dr. R. Comber 26th November, 1970. Dear Sir, S. B. S.G.I.e.ttnr No. 144 I have pleasure in enclosing a copy of note~ dated 5fi~ Novembe.r by the Director on a meeting with Drs. C. Izard and C. Lib~rman of S.E.I.T.A. on 29th October (It 1494). Yours faithfully, D.H. Beese, Secretary. / I Enc, 0 cZ~ c:Z)

TOBACCO RESEARCH Telcphonc : OI - 82/3 2041 Telc,jr(m~ : Tobeo,*. London. S.W. 1. CONFIDENTIAL Dr. R. Comber, COUNCIL Glen Ilousc. Stag Place. London. S.W.t. 3rd November, 1970. Dear Sir, S. B.S.G. Letter No. 143 I have pleasure in enclosing copies of the following papers :- 1. Minutes of the S. B. S.G. meeting held on Wednesday, 14th October (H 1467). 2. Paper on the relevance of T. P.M. Yields and Sldn Painting (H 1478). Paper by Dr. R, F. Dav~s et al I am pleased to inform you that the paper (H 923) "Pulmonary adenomata induced by carcinogen treatment in organ culture. Irufluence of increasing amounts of carcinogen" by R.F. Davies, I.R. Major and Elizabeth R. Aberdeen has been accepted for publication in the British # Journal of Cancer. I will let you know as soon as we know in which issue it will appear. Yours faithfully, D.H. Beese, Secretary. mucs. CD O

• . TOBACCO RESEARCH TeJ~phone : 01- 828 204t Tele91-ums: Tobcom, London. S.W 1. COUNCIL Glen House, Slag Placc, London, S.1,~. 1. CONFIDENTIAL Dr. R. Comber. 23rd October, 19"/0. Dear Sir, S.B.S.G. Letter No. 142 I have pleasure in enclosing copies of the followirg papers :- i. Paper dated 19th October from the Imperial Tobacco Group Ltd., on the Drikold versus impact/on traps : Mouse Skin Painting Results (H 1430). 2. Notes dated 20th October from Dr. R.F. Davies on the International Symposium held in St. Lukes Hospital, Chicago, front 15th - 17th October, 1970 (H 1431). Yours faithfully, D.H. Beese, Secretary. t ,/ Encs. .,,..,a. 0 U~

TOBACCO RESEARCH Telephone : O| - 828 2041 Teleg2,ems : Tobcom..Lo-don. S.WA. CONFIDEhrrIA L Dr. R. Comber COUNCIL Glen House. Sta9 Place, London, S.%~,: I. 8th October, 1970. Dear Sir, S. B. S.G. Letter No. 141 Next Meetin~ The next meeting of the S. B. S.G. will be at 11.00 a.m. on Wednesday, 14th October at Glen House. Luncheon will be available. Copies of the following papers are enclosed for consideration:- ° 2. , Agenda (H 1367). Set of Tables (H 1363) bringing up to date the information contained in document H 1166. Notes dated 14th July by the Director on a discussion with Dr. R.S. Doll ou Wednesday, ! 8th July? 1970 (H 1013). Paper dated 3rd March by Dr. R, F, Davies on the study of changes in platelet behaviour in the cat ~" 323). Yours faith~lly, D.H. Beese, Secretary. Agenda Item 5 (a) 8 11 a EDcS. ~rl 0

• .° TOBACCO RESEARCH "rch,pho~,c: Ol- 828 204! TeJc~jvL[m~ "]'obcom, Lond~.,n. SW.I CONFIDENTIAL Dr. R. Comber COUNCIL Glen tlou~c. S~ag Ptacr. London, SA%'. 1 7th October, 1970. t I °, Dear Sir, S. B. S.G. Letter No. 140 I have pleasure in enclosing copies of the following papers: 1. Pzper by Dr. K. Rothwell on Experiments 1.1.3.20 to 1.1.3.22 (H 1166) 2. Paper dated 1Sth September from Mr. W.S. Paige on Dose Levels in Mouse Skin Painting Experiments (It 1319) 3. Progress Report from Dr. R.F. Davies on the Organ Culture Department at Harrogate (H 1357) 4. Progress Report by Dr. R.F. Davies on Cell Kinetics (H 1358) Yours faith~ully, D.H. Beese, Secretary. EIICS. 0 L~ L.N (..3"I 0

TOBACCO RESEARCH "l.'elepbonc: Ol-B28 2041. "I'cic~rl.n.s. Toheon:.Lomh,n.. S.W~I. COUNCIL Glen Hou.qe, Stag l)l~cc. Loi~dot~. S.V~: 1. C ONFIDENTIAL Dr. R. Comber. 25th September, 1970. Dear Sir, S.D.S.G. Letter No. 139 I havc pleasure in enclosing a COl))' of the Final Analysis of Experiment 1.].3.]3. Fractions C.G.J.L.N. (H 1178). Yours fa ithful]y, D.H. Becse, Secretary. ERIC. t L~ 0

TOBACCO RESEARCH Tz/tphone : 01- 828 2041 "I'~c 9z"am.s: Tobc~om. ,L,o.clo a. S.'W. 1. CONFIDENTIAL Dr. R. Comber .° b • .. COUNCIL Olzn House, Stag Placz, London, S,%K I. 19th August, 1970. Dear SLr, S.B.S.G. Letter No. 138 I have pleasure in enclosing copies of the following papers:- , Paper from Dr. J.H. Chesterfield entitled "The Drikold versus impaction traps: mouse skin painting results" (H 1160) . Membership of the T. R.C. Committees and Study Groups as at 3rd August, 1970 (H 1020) Yours faithfully, D.H. Beese, Secretary. EIICS. I / I w CD CD

o TOBACCO RESEARCH Telephone : 01" 828 2041 Telegrams: Tobcom.io~aon. S.W.I. CQUNCIL Glen Hour~. Slag Flacn, London, S.W. 1, CONFIDENTIAL Dr. R. Comber. 23rd July, 1970. Dear Sir, S.B.S.G. Letter No. 137 I have pleasure in enclosing copies of the following papers :- 1. Trans]aUon of fl}e Report (H 712) dated April 1970 from SEITA (H 1034). 2. Note oldted 22nd Jtdy on Study Group Representation (H zo35). Yours faithfully, D.H. Beese, Secretary. ]~nes. O I o

TOBACCO RESEARCH Telvpho.e: O1- 828 2041 Telcg,~.m: ]~bcom. I~.I,dot,. S.~q I COUNCIL Glen l{ousc, Slag Pluc¢, London, S.W.t. CONFIDENTIAL Dr. R. Comber 17thJuly, 1970. Dear Sir, S.B.S.G. Letter No. 136 I have pleasure in enclosing copies of the followin~ papers :- 1. Note dated 15th July on the Chairmanship of Study Groups (B 1019) 2. Final Analysis for Experiment 1.1.7.2. Standard Tobacco Comparisoa (H 1015). Yours faithfully, D.H. Beese, Secretary. ,/ Enos. C:) ....,a. J N

TOBACCO RESEARCH T,,Ivl,ho,'-c : 01- 828 .°0-1-I "}'cL.,j,-u.~s: Tot)co,.. Lo.do.. SW. I. COUNCIL G)en ]louse, Slag Placc, ].oizdon, S.W.I. CONFIDENTIAL Dr.R. Comber 14th July, 1970, ! Dear Sir, S.B.S.G. Letter No. 135 I have pleasure in enclosing copies of the following papers :- 1. Report on the visitof Dr. B.R. Davis tothe U.S.A., May 1970 (H 990). 2. Paper dated 10th July from Mr. P.N. Lee oa the Correct Evaluation of Palhologies Detectable only at DeatS" (H 997). Yours faithfully, D.H. Beese, Secretary. EI~CS. CD t.,4 t.n ~m

| ° t, TOBACCO RESEARCH Trh-phnne: 01- 8o8 2041 Tcl¢grums: Tobeom. LoMon. SW.I. COUNCIL Glen House. Stag Place. London. SA~ [. CONFIDENTIAL Dr. 1t. Comber. 8th July, 1970. / Dear Sir, S. B.S.G. Letter No. 134 I have pleasure in enclosing copies of the following papers :- ~t Paper by Dr. R.F. Davies et al entitled "Pulmonary Adenomata induced by Carcinogen Treatment in Organ Culture. Influence of increasing amounts of Carcinogen" (H 9233. Dr. Davies proposes to submit this paper to the British Journal of Cancer for publication. 2. Final Analysis of Experiment I. I. 3.12. Fractions G. H. J.K.L. (H 969). Yours faithfully, D.H. Beese, Secretary. o:" f EII~. C

TOBACCO RESEARCH TelZl:4'mne: O! - 828 2041 Te.Jecj~mnm- Tobcom..London. $.~l~J. COUNCIL Glen House, Stag Placc. London, S.V,: 1. CONFIDENTIAL Dr. E. Comber. 16th Juue, 1970. Dear Sir, S. B.S.G. Letter No. 133 I have pleasure in euclosing copies of the followiug papers .- I° 1 l~aper, with translation, entitled "Some mathematical considerations on the isolation of carciuogeuic substances H in cigarette smoke" by Jurueu Misfeld aud Jurgeu Timm (H 7s6). Report to the T.R.C. for the period December 1969 - June 1970 from Prof. H. Sndth of the University of Birmingham (H 863). Yours faithfully, D.H. Beese, Secretary. ~llcs. O t./,J J~

TOBACCO RESEARCH T,'lq,h.r,e: 01-1:128 204.1 'J'clr ~ L',,Im~ : Tobcom..London. S-W. 1 COUNCIL SI(1g l'hlcc, Lol).dolL S.W. 1, CONFIDENTIAL Dr. R. Comber. 21st May, 1970. Dear Sir, S. B. S.G. Letter No. 132 I have pleasure in enclosing the following papers :- 1. Minutes of the 21st meeting of the S. B.S.G. held on Thursday, 23rd April (H 655). 2. Paper by Mr. P.N. Lee on Tumorigenic Ratios (H 766). Yom's faithfully, D.H. Beese, Secretary. Encs.

TOBACCO RESEARCH Telcphonc: 01 - 828 2041 Tclegrums: Tobcom. London. S.W.I. CONFIDENTIA L Dr. R. Comber. COUNCIL Glen House, Sl~x9 Place, London, S.W.I. 15th May, 1970. Dear Sir, S.B.S.G. Letter No. 131 I have pleasure in enclosing a copy of a Confidential Report dated April, 1970 from SEITA (H 712) Yours faithfully, D.H. Beese, Secretary. EDC: t / # 0 0 O~

.. ,. i, TOBACCO RESEARCH TeJL'phonc : 01 - 828 -o041 l'eJeg~-omJ: Tobcom, Londov, S.~,~. I. CONFIDEN3~A L Dr: R. Comber COUNCIL Glea House, Slag Place. London, S.'~V. I. 16th April, 19/0. Dear Sir, S. B. S.G. Letter No. 130 ] have pleastu-e in enclosing a copy of a paper dated 14th April from Dr. K. Rothwell on the Proposed Skin Bioassay Programme for consideration at the S. B. S.G. meeting on Thursday, 23rd April under Agenda Item 8 (H 592) Yours faithfully, D.H. Beese, Secretary. EXit. /I t c=D CD

TOBACCO RESEARCH "J'.-k.pho.r: OI - 828 2041 "/~K',JV..,L~: ]'~b'o,z,.Lu,,(Io,[, S]'V. 1. CONFIDENTIAL Dr. R. Comber COUNCIL Glc,, l l,,(tse. Sln q Place. l.(Jn, Ion. S.W. ! 14th April, 1970. DeP.r Sir, S.B.S.G. Letter No. 129 I have pleasure h~ enc]osJng further papers for consideration at the S. B. S.G. meeting on Thursday, 23rd April:- A~enda Item . Mouse Transplant Project Prog-ress Report, April 1970 (H 580) , The Theoretical Implications of the Short Term Epidermal Hyperplasia Test from Mr. I.R. Major (H 579) o Hyperplasia Investigations - Progress Report, April 1970 (H 581) Yours faithfully, D.H. Beese, Secretary. Enes. ED Lrl CXD

,. • TOBACCO RESEARCH Telcphonc: 01-828 2041 T~.lcgs-nms: Tobcom.La.do.. 5.~r 1. COUNCIL GJen H,usc. SJug Placc, London. S.%~. 1. CONFIDENTIAL Dr. R. Comber 13th April, 1970. Dear Sir, Next Meedng S.B.S.G. Letter No. 128 The next meeting of the S. B. S.O. will be at 9.30 a.m. on Thursday, 23rd April at the Harrogate Laboratories. . 2. Copies of the following papers are enclosed for consideration:- Agenda (I-{.5,54) Harrogate Quarterly Progress Report (H 517) Agenda Item 9 Yours faithful/y, D.H. Beese, Secretary. I F / Enc s. O CD ~4D

TOBACCO RESEARCH Tel.-j,ho.c : Ol - 02~3 ~0-~! TeIe tu~ll~ : Tobco, n, Lo.dv.. S W. I. COUNCIL Glcu llo~se. Slag Pluc.c. Lm~don, SA~: 1. 9th April, 1970. CONFIDENTIA L Dr. R. Comber Dear Sir, S.B.S.G, Letter No. 127 I have pleasure in enclosing a copy of a letter dated 26th February to the Director from Herrn. A. Musil with attached Report on the "Animal Experiments with fl~e Smoke Cmxlensate of a Cigarette Tobacco after Various Treatments" (g 433). This Report has not yet been published therefore members are requested to treat it with confidence. Yours faithfully, D.H. Beese, Secretary. :E pc. O O rk.) ¢::D

°. o° TOBACCO RESEARCH Telephone: 01-828 2041 Tele.g,.ams: Tobcom.London. S.W.I. CONFIDENTIAL Dr. R. Comber COUNCIL Glen lloasc, Slog Place, London, S.%%: 1, 23rd March, 1970. /" it Dear Sir, E.C. Letter No. 751 T.S.C. Letter No. 831 S.B.S.G. Letter No. 126 7 am enclosing copies of Mr. Matchett's le~er of ]9th March in which it is regrethflly announced that Dr. ~Iacrne is resiguia~ from Carreras as from 31st July. (H 444). I have informed Carreras that I am sure the Executive Committee will welcome Dr. Wflli,'uns' attendance at the Technical and Scientific Committee and Sldn Bio-Assay Study Group meetings and tlmt Sir Charles Ellis as Chairman of T.S.C. will equally welcome it. Yours faithfully, Philip Rogers, Chairman. Enc. r,O

TOBACCO RESEARCH Telephone : Ol" 828 204.1 Teleg,.an~ : "[obcom., Londo,l. S~4,~. I. CONFIDENTIA L Dr. R. Comber. COUNCIL Glen House, Slag Place, London, S.~: I, 25th February, 1970. Dear Sir, S.B.S.G. Letter No. 125 I have plea::ure in enclosing copies of the following papers:- I, Paper dated _~,r(l February from Mr. P.N. Lee entitled "Multiple Tumours and Regressions (H 276) Reports by the Director to T. S. C. and Study Groups on the American Cancer Society beagle study (H 211, H 23S and H 268) Yours faithfully, D.H. Beese, Secretary. ! Enos. , ¢./,d r~ r,o

• • TOBACCO RESEARCH Telephone~ 01- 8,28 2041 Tele 9~ems: Tobeom. London. S W. 1 , COUNCIL Glen House, Sla9 Place. London, S.W. 1. COITF/DENTIAL Dr. R. Comber. 21st August, 1969. / f Dear Sir, S.B.S.G. Letter No. 112 Copies of the following papers are enclosed :- . 'A Study of the Effects of Altering the Tar/Nicotine Ratio in Experimental Tobacco Carcinogenesis' by. Dr.R.F. Davies and Dr. J.K. Whitehead (G 1153) (G 756 revised). . Notes dated 19th August by the Director on Recent Trends in the Mouse Skin Tumorigenicity of Cigarette Smoke Coudensate lu the U.K. and U. S.A. (G 1155). 1 Notes dated 19th August by the Director on Comparison of British and German Mouse Skin Painting Results (G 1156). Yours faithfully, D.H. Beese. Secretary. Sncs. cZ~

TOBACCO RESEARCH Tdephone : 01- 828 204.1 Telcgram-~; Tobcom. Lo.do.. S.W.I. COUNCIL Glen House. Slag Place, London, S.W.I. CONFIDENTIAL 7th August, 1969. Dr. R. Comber. Dear Sir, S.B.S.G. Letter No. 111 Copies of the following papers are enclosed:- I. Percentages of tumour bearing animals on fresh smoke - a comparison of Harrogate and Hamburg results (G 1088). 2. Paper from Mr. P.N. Lee entitled "A Comparison of the T.R.C. Standard Cigarettes T.4 and T.29". (G 1089). Yours faithfully, D.H, Beese, Secretary. ~DCS. 0

• ° ,, TOBACCO RESEARCH TeL-phonc : 01- 828 2041 Telegl.oms: Tobcom. London. S%~.I. COUNCIL Glen Ilouse, Stag Pluce, London, S.1*,: I. CONF]DENTIAL 6th August, 1969. Dr. R. Comber. Dear Sir, Io * S.B.S.G. Letter No. 110 Copies of the following papers are enclosed:- Paper dated 5th August by Mr. P.N. Lee on Comparative tumourigenicity of the four dosing regimes (G 1111). Corrections to the translations of the three reports from the Wissensehaftliche Forschungsstelle (G 1101). Yours faithfully, D.H. Beese, Secretary. r ! E nos. "-.4

TOBACCO RESEARCH Tc.kT,honc : O1 " 828 204,1 Tclcg,.ams: Tobcom. Londoz:, S~tt. I. COL~FIDENTIA L Dr. R. Comber. COUNCIL Glen House, Slag Place, I.ondon, S.W. 1 1st August, 1969. Dear Sir, S.B.S.G. Letter No. 109 Copios of the following papers are enclosed:- i. Minutes of the 18th Meeting of the Skin Bio-assRy Stud)' Gruup held on Tuesday, 22rid July (O 1081) 2. Note dated 31st July by the Secretary on Study Group Represent.~tion (G 1090) 3. Extract from D-Mark, July 19.69 pp. 13-16 entitled" "Fear Has Gone Up In Smoke" (G 1093) 4. Extract from D-Mark, July 1969, pp. 45-48 entitled "DM Purchasing guide. Everything about quality and prices" (G 1094) $ Yours faithfully, D.H. Beese, Secretary. Encs: 0 L.,4 m Ln L,,I CID

.° "b ° ° TOBACCO RESEARCH Telcphone : 0!- 828 2041 Tide qrum$ : Tobcom, London. S.'W.I, COUNCIL Glen llouse• Slug Place• ]~ndon, SA~ I. COI~FIDE NTL%L Dr. R. Comber. 28f3 July, 1969. /- Dear Sir, S.B.S.G. Letter No. 108. Enclosed are paris 2 and 3 of the Report from fi~e Ins~t~t der Wissenschaftlichen Forchungsstclle im Verband der Cigarettenindustrie, Hamburg (G 1038 and G 1039). Yours faithfully, D.H. Beese. Secretary. I' / En0s° O ,,O

TOBACCO RESEARCH TclcFho.c : OI - 82[:} 2041 ~1-" 9r.ms: Tobeom. London, 5.W, 1 COUNCIL Glen House, S~a9 Place. London. S.~V: I. CONFIDENTIAL Dr. R. Comber (Research and Development Est.) 22nd July, 1969. Dear Sir, S. B. S.G. Letter No. 107. Copies of the following papers are enclosed :- 1. Press release dated 24th June from the ForschtugsstcUe, HambulN on the results of their first long-term mouse painting experiment (G 1043). 2. Press Cutting from Bild Zeitung dsted 25th June on the research at Hamburg (G 1042). 3. Press Cuzting from the Hamburger Morgenpost dated 25th June on the research at Hamburg. (0 1044). Yours faithfully, , D.H. Beese. Secret~ry. Encs. C:D

-, -. .° TOBACCO RESEARCH COUNCIL Telephone: OI- B28 2041 TeJegr,~r~ ~ Tobcom. London. S.W. 1. Gle- HoQ$c. S~a9 Placc. London, S.W.I. coNFIDENTIAL Dr. 11. Comber, (Research and Development Establishment) 16th July, 1969 f- Dear Sir, Next Meeting S.B.S.G. Le~er No. 106 The next meeting of the S.B.S.O. will be at 11.00 a.m. on Tuesday, 22rid July at Glen House. Luncheon will be available. Enclosed for consideration at the Meetl~ is a copy of the Agenda (G 1019) / # J Eno, ~, Yours faithfully, D.H. Beese Secretary.

• • | TOBACCO RESEARCH Td~phm~e : 01 - {}28 2041 "rz/eg~lms: Tobeom. Londo,. 5.W. 1. CONFIDENTIAL Dr. R. Comber. COUNCIL Glen Hou.~. Stog Place, London. S.W.I. 15th July, 1969. / .° Dear Sir, S.B.S.G. Letter No. 105 Copies of the following papers are enclosed :- . Smoke Condensate Fract/onation Charts and .~,[ousc Painting Reference Numbers. (G 907) (replacing F 781 as modified by F 891). . Report from the Institut der Wissenschaftlichen Forschungsstellc im Verband der CL~aret~.enindusta-ic, Hamburg. Part 1 Experimental Investigations into the Tumour-Producing Effect of Cigarette SmoI~e Condonsates on the Sldn of the Mouse (G 982). Parts 2 aud 3 of tlus paper will be circulated as soon as" they have been translated. . Notes dated 10th July by the Director on Discussions in Germany on the 8th and 9th Ju/y, 1969 (G 1005). 4~e , Tissue Culture Progress Report July, 1969 by Mrs. rE. R. Sproull (G 1006). Hyperplasia Investigations Progress Report, July 1969 from Mr. I.R. Major (G 1007). Paper dated 14th July from Dr. R.F. Davies on proposed Mouse Skin Painting E~TJeriments to start in October, 1969. (G ~008). Yours hithfuny, D.H. Beese. Secretary. Encs. O r~O

• t "' • r | ' TOBACCO RESEARCH "l'cl,'ph,,i~,-. Ol-llt2G 2041 'releUt.ume. Tobe.,m. Lo,,ton. SW 1. CONFIDENTXA L Dr. R. Comber. COUNCIL G|cn Hutlse, Slag l'lacc, Lo,,([(,,,. S.W I 25th June, 1969 Dear Sir, S. B. S.G. Le~er No. 194 A copy of the followir~ paper is enclosed:- Correction to G 866 - Summary of the Final Analysis of all Experiments completed to Decemhc,: i968 (G 904) EIIc. Yours faithfully, D.H. Beese Secretary. /r I .--.A O E~ t.,4 w Q,4 Q,4

TOBACCO RESEARCH Telephone : 01 - 82B 20.-1.1 Telegran~. Tobcom. Lo,,do,. 5.W.I. COUNCIL Glen House. StQ9 Place, London. S.W.I. CONFIDENTIAL Dr. R. Comber. 17th June, 1969 Dear Sir, S. B.S.G. Letter No. !03 Copies of the following papers are enclosed:- l. Letter dated 10th June to the Director from Dr. F.J.C. Roe with corrections to his paper on T2/T3 Condensate Carcinogenicity Comparison Test (G 852) 2. Notes byDr. R.F. Davies onDr. F.J.C. Roe's paper (G 740), and G 834 (G 865) 3. Letter dated 12th June to the Director from P. Vesperini (G 863) 4. Summary of the Final Analysis of all Experiments compl,ted to December 1968 (G 866) , Yours faithfully, D.H. Beese Secretary. Enc8. O O

TOBACCO RESEARCH Telephone : O! - 828 2041 Tele 9,.an~: ~obeom, London. 5.W. 1. COUNCIL Glen HOUSe, Slag Place, London, S.V,: I. CONFIDENTIAL Dr. R. Comber. llth June, 1939 Dear Sir, S. B.S.G. Letter No. 102 Next Meeting The next meeting of the Skin Bio-assay Study G roup has been arranged for 11.0 a.m. on Tuesday, 22nd Juiy, 1969, at Glen House. Paper for information Enclosed is a copy of notes dated 6th June, 1969, by the Director on G 740, Dr. F.J.C. Roe's paper (G 834). Yours faithfully, D.H. Beese. Secretary. f I Eric. C)

TOBACCO RESEARCH l'eh'l,hnne O! " 8-o(3 .°04"1 Tclcsr.ms Tob,-om. io.duu. S W' I CONFIDE NTIA I, Dr. ft. Comber COUNCIL Glen lh,u.~c. SIo.q l'lucc. J,oltdon..~ W I. 6th June, 1969 Dear Sir, S.B.S.G. Letter No. 101 Copies of the following papers ~re enclosed:- , A Study of the Effects of Altering the Tar/Nicotine Ratio h; Experimental Tobacco Carcinogenesis, by Dr. P.. F. Davics and Dr. J.K. Whitehead, G 756 (Revision of G 616) 2. Final Analysis of Experiment I. 1.9.3. (G 76]) 3. Final Analysis of Experiment 1.1.9.4. (G 798) . Report to the T. R. C. December 1968 - June 1969 from Diana S. Davis r s, and A.E. Williams, Birmingham University, on .Methcd., for the imrcAucti~n of Biologically Active .Material kuto ~nd onto the surfaces of AnLnm! Ce!ls(G 80~ 5. Testing Scheme for Agriculturg.1 Chemicals The atfached 0aper is a re-draft by Dr. R.F. D~vies of the skm-bioaasay section of th~ Guidance Notes on techniques for testing agricult, aral chemicals. Yours faithfully, D. It. Beese. See retary. Encs. CD 0 £Jl C~

°. TOBACCO RESEARCH Telephone : Ol- 028 2041 Teleol.am.s: Tobeom.London. SW1. COUNCIL Glen House. Slag Place. London. S.W. 1. CONFIDE NTIA L Dr.. D. G.I. Felton 6th June, 1969 $ ! Dear Sir, T. S.C. Letter No. 733 S. B. S.G. Letter .Co. 100 Skin-Bioassav Research Conference I have to advise you that the Technical and Scientific Con;mit~.Pe has decided to postpone the Skin-Bio~ssay Research Conference :vh!ch had been arranged for Thursday, 12th Jm~e, ].969 at these (,ffices. The conference will be re-arranged after the SkJn-Bioassay Study Group has had an opportm~ity of reviewing the Harrogatc research programme and has formulated its recommendations for consideration at ti~e Colzference. The Chairman of S.B.S.G. would be pleased if member eompa_n.ies would mtbmit their comments on the Harrogate skin-bioassay researci~ programme and facilities without delay to this office as previously arranged. The attached paper (G 806) has been prepared by Gallaher Ltd as their contribution to the discussion. Yours faithfully, D.H. Beese, Secretary. Eric. O w

• t ! J TOBACCO RESEARCH "]\:Jcpho,c : O1 - U;28 20-1-1 "rcl,,9~.o,,,s; Tobeom. London. S.W. 1. CONFIDENTIAL Dr. R. Comber COUNCIL Glen llousc. Slag Placc. Loi,doa, S.%%: I. 20th February, 1970 Dear Sir, S. B. S.G. Letter No. 124 I have pleasure in enclosing a letter dated 27th January to the Director from Dr. R. Schlenker with attached interim report on the 2nd German long term sldn painting experiment (H 213). This information is confidential until the experiment is completed. Yours faithfully, D.H. Beese Secretary. Enc. 0 c~

,. TOBACCO RESEARCH Telephone : 01- 828 2041 Telegrams: Tobcom.London. SW.1. CONFIDENTIA L Dr. R. Comber. COUNCIL Glen House, Slag Place, London, S.%V. I. 23rd January, 1970 Dear Sir, S.B.S.G. Letter No. 123 I have pleasure in enclosing copies of the following papers:- . Minutes of the 20th Meeting of the S. B. S.G. held on Thursday, 15th January (H 131) 2. Report dated 19th January from Dr. R.F. Davies on a meeting of Pathologists held at the Harrogate Laboratories on 13th and 14th January (H 114) 3. Letter dated 17th December 1969 to the Director from Mr. Vesperini with attached original and translation of a report on the Effects of Acrolein on Vegetable Cells (H 121). Will Members please note that this document is confidential until published. ! Paper for publication We are advised that the paper by Mr. I.R. Major on "Correlation of initial changes in tlle mouse epidermal cell population with two stage carcinogenesis - a quantitative study" (G 1173) has been accepted for publication in the British Journal of Cancer. Yours faRhfully, D.H. Beese, Secretary. Encs. O CD t.,4 t.,4

r. °" ,/ TOBACCO RESEARCH COUNCIL Telephone: 01" 028 2041 "l'clcgr~r~: Tobcom. London• 5.~. 1. Glen House, Slag Place, London, S.~¥. 1. 12th January. 1970. CONFIDENTIAL Dr. R. Comber. Dear Sir, S.B.S.G. Letter No. 122 Next Meetin,~ The next meeting of the S.B.S.G. will be at 11,00 a.m. on Thursday 15th January at Glen House. Luncheon will be available. Copies of the following papers are enclosed for consideration :- Agenda Item 1. Agenda (H 54) . Paper dated 1st Janu2ry from Dr. R.F. Davies on The Biological testing of Condensate from the Harrogate Impaction Trap Instant Condensate Machine (H 27). Paper for Information :- 6 Note dated 5th January on Study Group Representation (I-I 16). f Yours faithfully, D.H. Beese, Secretary. EnoS.

TOBACCO RESEARCH TehT)hone : OI- 826 2041 Tzlc grams: Tobcorn. Londo.. 5.W. 1. CONFIDENTIAL Dr. R. Comber COUNCIL Gle,, House, Slag Plocc. London, S.%%: 1. 2rid January, 1970 Dear Sir, S. B.S.G. Letter No. 121 I have pleasure in enclosing copies of the followL~ p~pers:- • I. Paper. by Dr. R.F. Davies entitled "Tumorigenicity of very fresh tobacco smoke condensate to mouse skin" (G 1718) 2. Hyperplasia Investigations Progress Report- January, 1970 from Mr. I.R. Major (G 1732) 3. Tissue .Culture Progress Report for December, 1969 (G 1733) Yours faithfully, D.H. Beese Secretary. t Encs. C:D C:D 0-,

• I ,o TOBACCO RESEARCH "l'd~Dhone : OI - B~8 .nO4! l;clc ~runL,~ : Tobcom. Londo.. S.W 1. COb'FIDE NTIA L Dr. It. Comber COUNCIL Glen House• Slag Place, London, S.W. 1. 16th December, 1969 Dear Sir, S. B. S.G. Letter No. 120 I have pleasure in enclosing a copy of a final draft of the paper by Drs. F.J.C. Roe and R. Peto entRled "Comparative Carclnogenicity for Mouse-Sldn of Smoke Condensate prepared from the same Tobacco cured by Two Processes" (G 1595) Yours faithfully, D.H. Beese Secretary. Enc. / / m (ZD rk.)

.° TOBACCO RESEARCH "I'ch'l',h,',r~c. 01" 82F3 204I "]'clcg,'un,-~ Tobc,',m. Lo.do.. 53¢. 1, COUNCIL GI(n House. S~a9 Place. London, SAq: I. CONFIDENTIAL Dr. R. Comber 12th November, 1969. r / Dear Sir, S.B.S.G. Letter No. 119 Copies of the following papers are enclosed :- 1. Letter dated 16th October from the Huntingdon Research Ccnt~'e (G 1405). 2. Note dated 10th November by the Secretary on the Imperial Tobacco Group representation on T. R.C. Committees and Study G~roups (G 1522). Yours faithfully, D.H. Beese. Secretary. ENOS. CZ) r,,o (3o

TOBACCO RESEARCH Telephone : OI - 828 .°041 Tel,~ ~l.,ms: Tobc ore. Lu,don. S.W" 1. CC)hTIDE h~i'IA L Dr. R. Comber COUNCIL Glen Housc. 51~ Place. Lonclov.. S.1V. 1 9th October, 1969 Dc.Lr Sir, S.B.S.G. Letter No. 118 Copies of the following papers are enclosed:- 1. Minutes of the 19th Meeting of the S. B. S.G. held on Wednesday, 1st October (G 1364) 2. Paper dated 29th September from Mr. P. N, Lee on An evaluation of Hamburg results and a comparison with similar Harrcgate experiments (G 1338) J °.' Y Encs, Yours falthfully, D.H. BEESE Secretary. ~w C~ C~

TOBACCO RESEARCH Te~Thone : 01- 828 2041 TeJcgrmr~: Tobcom, Lor~ou. S.%V:I. CONFIDENTL%L Dr. R. Comber COUNCIL Gler~ HoUSe, Slag Flace, London, S.W. 1. 18th September, 1969 Dear Sir, S.E.S.G. Letter No. 117 Next Meeting The next meeting of the S. B. S.G. will be at 9.30 a.m. on Wednesday, 1st October at the H.~rrogate Laboratories. Copies of the following papers are enclosed for consideration:- , 2. Agenda (G 1276) Proposed Amendments to the Minutes (G 1081) of the 18th Meeting of the S.B.S.G. (G 1275) Notes dated 16th September by the Secretary on Unive~.'sity of Kentucky Cigarette Samples (G 1269) Yours faJthfully, D.H. BEESE Secretary. Agenda Item 2 , Encs. N.,.e, 0 CD (.71 0

L TOBACCO RESEARCH Tdeplmne: 0|- 828 2041 Telegrams: Tobcom. London, 5~" I. COUNCIL Glen House. Slag Place, London. S.W.I. CONFIDENTIAL Dr. R. Comber. l£th September, 1969. Dear Sir, S.B,S.G. Letter No. 116 Copies of the following l~pers are enclosed :- lo Paler dated 9th September by Mr. P.N. Lee entitled "Is RelaUve Tumorigeu/ci~: the same as Relative Carcinogenicit'~' (G 1240). 0 Paper dated 9th September by Mr. P.N. Lee entitled "Couclusious reached by Lee standardisiu~ P, oers T2/T3 results" (G L?.,il). o Paper dated 9th September by Dr. Whitehe:d, Dr. Davies and Mr. P. ~N. Lee entitled "Future Mouse Skin PRinting Experiments" (G 1242). Yours faithfully, D.H. Beese. Secretary. Encs. O L/,4

.° ° . .~ ,.° TOBACCO RESEARCH Telephone: 01- 828 °041 Tele 9ran*-,: Tobcom. London. S~: I. COUNCIL Glea Housc, Slag Placc, London, S.V%'. I. CONFIDENTIAL Dr. R. Comber lOth September, 1969 t f oo Dear Sir, S.B.S.G. Letter No. 115 Copies of the following papers are enclosed:- 1. Notes dated 4th September by the Director on Dr. Roe's Paper - Age Standardised Percentages of Turnout Bearing Animals {G 1212) 2. Paper, with translation, extracted from Experientla, 15th July, 1969, 2_55, 714-$, entitled The Effect of Benzp)Tene, cigarette smoke condensate and passive smoking on the formation of ZoxRzolami,lhydrox?4ase, by W. Dontenwill et al. (G 1224) 3. Amendment to Doc,.unent G 681 (G 1231) , Yours iRith~ully, D.H. BEESE Secretary. Encs. 0 L~

Z • ° TOBACCO RESEARCH T~c-p},one : 01 - 828 2041 T©le 9earn., : Tobco,n. London. S.~' 1. COUNCIL Glen House. Slag Piece, London. S,~Ar. 1. CONFIDENTIAL Dr. R. Comber 3rd September, 1969 Dear Sir, S. B.S.G. Letter No. 114 Copies of the following papers are enclosed:- I. Notes dated 27th August by the Director on a discussion with Dr. F.J.C. Roe on 26th August (G 1192) 2. Note dated 2nd September by the Director (G ] 199) concerning the paper by Lee and Timm G 1179. Yours faithfully, D.H. BEESE Secretary. Enos. C C

° .° TOBACCO RESEARCH TzI~plmne : Ol - 828 20~1 Telegvoms: Tobcom. London, S.~V. I. COUNCIL Glen llousc. Slag Ploce. London, S.'~r. 1. CONFIDE NTTA L Dr. R. Comber. 26th August, 1969 f" Dear Sir, S. B. S.G. Letter No. 113 Copies of the following papers are enclosed:- 1, Comparison of British and German Mouse Skin Painting Results by Mr. P.N. Lee and Mr. J. Timm (G 1172) . Notes dated 25th August by the Director on the above paper (G 1179) 3~ Paper entitled "Correlation of Initial Changes in the Mouse Epidermal Cell Population with Two Stage Carcinogenesis - A Quantitative Study" by Mr. l.R. Major (G 1173). This paper is for submission to the British Journal of Cancer. . Paper by the Director on Recent Trends in Mouse Skin Tumorigenicity of Cigarette Smoke Condensate in the U.K. and U.S.A. (G 1175) (revision of G 1155). Yours falthfully, D.H. BEESE Secretary. En0s, ' 0 0 J~ °

TOBACCO RESEARCH T~e : 01-828 20,41 Tel. 9s.omo: Tobeam. london. S.W. 1. COU NCI L (~¢n ]['][OtUNt, ~ag Placz. London. $.~. 1. CONFIDENTIAL Dr. R. Comber 21stMay, 1969. Dear Sir, S.B.S.G. Letter No. 99 Encs: Copies of the followin~ papers are enclose&- 1. Ftnal Analysis of Experiment 1.1.11.2. (G 726) w 34 D Final Analysts of Experiment 1.1.1.6. (G 739.) Addendum to G 681, Final Analysts of Experiment 1.1.7.1. (G 733) Letter dated 6th May to the Director from Dr. F.J.C. Roe with attached draft of the main T2/T3 condensate comparison test, prgpared for publication in the British Journal of Cancer (G 740) Yours fatthfully, D.H. Beeee, Secretary. CO

• . TOBACCO RESEARCH COUNCIL Ttl,cl~e,e 01-828 2041 Td*gl.e~: To~om. Lo~lon, S.W. I Gle~ House. Slag Pi=cc, London. S.W.I. CONFIDENTIA L Dr. R. Comber I3th May, 1969. Dear Sir, S. B.S.G. Letter No. 98 Copies of the following papers are enclosed:- 1. Fiv.al Aualysis of Experiment 1.1.7.1 (G 681). 2. FinaI Analysis of Experiment 1.I.1.3 (G 700). 3. Final Analysis of Experiment 1.1.1.7 (G 701). Yours faithfully, D.H. BEESE, Secretary. ! / l EllcS. C:) O

TOBACCO RESEARCH T~e" 01-828 204I Tcbg,Nmu: Tol~cm.~o,-. S.W.I. COUNCIL G|¢n Hour, 51a9 Place, London. S.W.I. CONFIDENTIAL Dr. R, Comber 2ndMay, 1969 f Dear Sir, S. B. S.G. Letter - No. 97 Copies of the following papers are enclosed:- Io Paper dated 22nd April by the Director on Recent Information about Smoke Carclnogenicity (G 638) J A Study of the Effects of Altering the Tar/Nicotlne Ratio in Experimental Tobacco Carcinogenesis by Dr. R.F. Davies and Dr. J.K. Whitehead (G 616) (G 523 revised). Following the comments made by T. S.C. at its meeting on let M~.y a third draft of this paper will be prepared. t o "The Mouse g~tn Carcinogen/city of Cigarette Smoke Condensate: Fractton~ted by SoLvent Part[tton Methods" by Dr. J.K. Whitehead and Dr. K. Rothwe11, amendments to G 441 (G 613) F Report on EnvLronmentai Carcinogenesis: Threshold Concentrations of Carcinogens and Cocarelnogens by Eula Blnglmm and Hans L. Falk (G 598). Members will note that this paper has not yet been published ahd is therefore confidential. o Fins/Analysis of Experiment 1.1.3.8. (G 628) 6, Final AnRlysls of Experiment 1,2.1.1. (G 629) 1 Final Analysis of Experiment 1.2. I. 2. (G 630) Enos. Yours faithfully, D.H. Beese Secretary. 0 0 0

., TOBACCO RESEARCH T~kpkaQe: 01425 2041 Tel=~,e=aJ: Tobeem, l,o~loa. S.W.I. COUNCIL Glel 'J~oQN ,, Stag Plaez, London. S.W. 1. CONFIDENTIAL Dr. R Comber. 23rd April, 1969. Dear Sir, S.B.S.G. Letter No. 96 C.S.G. Letter No. 194 /I l Testing scheme for Agricultural Chemicals The Chairman of the Agricultural Chemicals Study Group has asked if S. B. S.G. and C. S.G. couki take an early opportunity to examine the "Guidance Notes ou Techniques recommended for use in the Bio-assay of Tobacco Smoke Coudeusates" (]3 93 enclosed) with a view to bringing it up-to-date and in line with the 3rd Edition of the T.A.C. testing scheme for agricultural chemicals (G 586 enclosed). It would be appreciated if, when the respective Study Groups have considered this matteT, their proposals could be forwarded to Glen House. Yours faithfully, D.H. BEESE, Secretary. Ir.ncs.

TOBACCO RESEARCH T~6:01-828 2041 T,z.le 9s'ama: Tobeom. Loudon. S.W.1. COUNCIL G|zil HOQ.~, Slag Place, London. S.W.I. CONFIDENTIA L Dr. R. Comber, lSth April, 1969 Dear Sir, S. B. S.G. Letter - No. 95 T. S.C. Letter - No. 717 SkJn-Bioassay Research Conference It is now proposed that the Joint meeting of T.S.C. and S.B,S.G. to review the Harrogate skln-Bloassay research programme should be held at Glen House at 10.30 a.m. on Thursday, 12th June, 1969. It would be appreciated if any contributions for the conference from member companies could be received at this office by not later than Friday, 30th May. Enclosed are three documents, G 581, G 576 and G 577, which are relevant to the above conference. ! Yours faithfully, D.H. Beese Secretary. EDC$. O r~D

TOBACCO RESEARCH T,.tq~:~me- 01-82S 2041 Tds g'em~: Tobee~. LeaJoa. S.W. 1. COUNCIL G~¢8 Ho~s~ 0 Sta9 PlacE, London, S.W.l. CONFIDENTIAL Dr. R. Comber 15th April, 1969• / ? Dear Sir, S.B.S.G. Letter- No. 94 Skin Bto-assay Research Conference As a result of the illness of Dr. R.F. Davies, tt has now been decided to postpone the skin bio-assay research conference which was to have been held on Wednesday, 23rd April. Members will be advised of the new date for the meeting as soon as it has been fixed. Papers for Publication:- lo Paper suitable for publication in the British Journal of Cancer by Dr. R.F. Davies and Dr. J.K, Whitehead entitled "A Study of the Effect of altering the Tar/Nicotine Ratio in Experimental Tobacco Carcinogensts" (G 523) Re Paper written up in a form of a letter to Nature by Dr. R.F. Davies entitled 'q~unortgenicity of fresh Tobacco Smoke Condensate to Mouse ~Lu" (G 524) The authors would be grateful to receive any comments and suggestions for amendment from members. Papers for Information:- 3. Final Analysis of Experiment I. 1.9.1. (G 563) e E~os. Notes and comments on some aspects of the work of the T.R.C. by Prof. W.V. Mayneord. (G 564) Yours faithfully, D.H. Beeee Secretary __.b C t.,-

° TOBACCO RESEARCH T~ee : 01-828 2041 T,,.Izgs.,ama- Tol~eom. London, S W. 1. COUNCIL GJcD Houge, Stag Placz, London, S.W.I. CONF[DENT[A L Dr. R. Comber. 1st April, 1969. Dear Sir, S.B.S.G. Letter- No. 93 Enclosed Is a draft 3rd edition of the T.A. C, testing scheme (G 503). Yours faithfully, D.H. Beese, Secretary. Enc: O t.n J~

°, TOBACCO RESEARCH Te~,pb~ne: 01-828 2041 Tzlzg'ean~: Tol~om, Loudon. S.W.1. COUNCIL Glen Hour. Slag Place, London, S.W.t. C ONFID ENTIA L 28th March, ]969. Dr. R. Comber, Dear Sir, Secretary's Letter- S.B.S.G. 92 Copies of the following papers are enclosed:- 1. Minutes of the 17th meeting of the Skin Bio--assay Study Group held on 20th March (G 490). 2. Paper by Drs. J.K. Whitehead and K. Rothwell entitled 'q'he Mouse Skin Carcinogenicity of Cigarette Smoke Condensate: Fractionated by Solvent Partition Methods" (G 441). It is proposed to Bubn%tt this paper to the British Journal of Cancer. Dr. Whitehead would be grateful to receive any comments and suggestions for amendments from members. Yours faithfully, H.B. Grice Sec retary. t I Encs. C C

TOBACCO RESEARCH Tek.ph~z : 01-828 2041 Tzl=~: Tobeom.London. S.W-I. COUNCIL G|eD House. S~acj Placz, London. S.W. |. CONFIDE NTIA L 17th March, 1969. Dr. R. Comber, Dear Sir, Secretary's Letter - S.B.S.G. 91 Skin Bio-assay Research Conference A joint conference of members of T.S.C. and S.B.S.G. has been provisionally arranged for 10.30 a.m. on Wednesday, 23rd April, 1969 at Glen House. The purpose of the conference is to review the skin btoassay research programme at Harrogate. .,' Dr. R.M. Macrae has suggested that, in order to derive the greatest benefit from this meeting, member companies should be asked for a comprehensive statement of where they feel the main emphasis of skin bloassay work at Harrogate should be directed. It would be appreciated, therefore, if any contributions from member companies could be sent to this office by Friday, 11th April. t Papers for consideration at the S.B.S.G. meettn~ on Thursday, 20th March:- Agenda...Item ~o Mouse Transplant Project, Progress Report for March, 1969 from Mr. I.R. Major (G 412) 1 Hyperplasia Investigations, Progress Rel~brt for March 1969 from Mr. I.R. Major (G 411) Encs: Yours faithfully, H.B. Grice Secretary. O C=D CY,,

o TOBACCO RESEARCH T,k'pl*~e : 01428 2041 T~ltol~mm: Tobit. London, S.W.I. COUNCIL Glen Houl~, Slag Place, London, S.W. 1. CONFIDENTIAL Dr. R. Comber, 13th March, 1969. ,,/ t Dear Sir, Secretary's Letter- S.B.S.G. 90 Next Meeting The next meeting of the Skin Bto-assay Study Group will be held at 11.00 a.m. on Thursday, 20th March at Glen House. Luncheon will be available. An Agenda (G 398) is enclosed, together with the following supporting papers:- . o . Ai~enda Item Papers by Drs. R.F. Davies and J.K. Whitehead concerning proposed mouse skin painting experiments for May, 1969. (G 368) 5 Progress Reports on extra-mural research, December 1968 (G 133) 8 A Survey of standard carcinogen experiments (O 3~6) 11 Summary from Mr. P.N. Lee of Monthly Report 111/1969 (G 401) 11 Yours faithfully, H.B. Grice Secretary. Encs. CD 0 -..4

. .° TOBACCO RESEARCH Tzicpbcme- 01-828 2041 Tde~: Toi~om. London. S .W'. 1. COUNCIL Glen House, SI~j Placz, London. S.W. 1. / CONFIDENTIAL Dr. R. Comber. 27th February, 1969. Dear Sir, Secretary's Letter - S. B.S.G. 89 Copies of the following papers are enclosed:- 1. Summary of Final Analyses of all Experiments finished before December 1968 - Conclusions based on Final Results for all T tnnour Bearing Animals Standardised (G 175). 2. Letter dated 6th February to the Director from Dr. M. Friedman concerning the Type B Smoking Engine (G 225). Yours faithfully, H.B. Grice Secretary. Encs. CD t.P4 M (..rl co

o. TOBACCO RESEARCH Telephone: 01-828 204I Tdegs.ms~: Tobeom.Londo-. S W1. COUNCIL Glen House. Stag Place, london. S.W.I. CONFID E NTLA L 5th February, 1969. Dr. R. Comber, I I Dear Sir, Secretary's Letter- S.B.S.G. 88 Copies of the following papers are enclosed:- I. The new version of the Cigar Paper by Drs. Day &~,, Davies with revised page Ii inserted (G 155) 2. Extract from a letter to the Secretary from the Chairman of the Skin ]3io-Assay Study Group (G 156). This adds to and replaces G 136 circulated with S. B. S.G. 87. 3. Final Analysis of Experiment I. 1.9. I. (G 161) Yours faithfully, : H.B. Grice Secretary. El~CS: O CZD

° TOBACCO RESEARCH T~z: 01-825 2041 T,.lzg,u,,,,,. Tobeoa,.I,,oudo,. S.W.. 1. COUNCIL G]e~ Hour, Stag Place, London. S.W. 1. CONFIDENTIAL 29tb January, 1969. Dr. R. Comber. Dear Sir, Secretary's Letter- S. B.S.G. 87 Copies of the foUowing papers are enclosed:- 1. Final Analysis of Experimeut 1.1.6.1. (G 125). 2. Ftnal Analysis of Experiment 1.1.9.2. (G 126). 3. Extract from a letter to the Chairman of the S.B.S.G. from Dr. R.F. Davies (G 136). • ,' Yours faithfully, H.B. Grtce Secretary. EIICS. t 0 0 w cr~ o

TOBACCO RESEARCH Tei,rpi~:me : 01"828 2041 TeJeg~m~: To~om.Lon,Jon. S WI COUNCIL G]~n HOUS4~. Stag ]>lace, London, S V~. J. CONFIDENTIAL Dr. R. Comber. 22rid January, 1969. Dear Sir, Secretary's Letter - S. B.S.G. 86 Copies of the following papers are enclosed:- 1. Membership of the Tobacco Research Council (at 15th January 1969) (G 70). 2. Final Analysis of Experiment 1.1.6.3. 'fLow Tar Trial" (G 88). 3. Flnal'-Analysis of Experiments 1.1.1.4., 1.1.1.5., 1.1.2.3., 1.1.8.1. (G 86). Yours fatthfully, H.B. Grice Secretary. / t EIIcs. t.,rt

TOBACCO RESEARCH T.~ho.e: 01-828 2041 TzlzgmmJ: Tob~,,-,.London. S.W.I. COUNCIL G]GB HOHge. Sing Place, London. S.W. 1. CONFIDENTIAL Dr. R. Comber. 15th January, 1969. Dear Sir, _S .~. retary's Letter- S.B.S.G. Copies of the following papers are enclosed:- I. 2. . 85 Codification of Experimental Products as at 6th January 1969 (G 16) Final Analysis of Experiment 1.1.4.2. "Anticarcinogenic Action of Nicotine - 2" (G 49) Final Analysis of Experiment 1.1.11.1. "German Condensates°' (G 57). Yours faithfully, H.B. Grice Secretary. Enos. M C~ O'-

TOBACCO RESEARCH T,4fl~e : 01-828 2041 Tde~-asna: Tobcom. London. S.'W.1. COUNCIL Glen Houl~, Slug Place. London. S.W. 1. CONFIDENTIAL Dr. R. Comber, Dear Sir, Secretary's Letter- S.B.S.G. 84 Copies of the following papers are enclosed:- 31st December, 1968. . o Minutes of the 16th meeting of the S.B.S.G. held on Thursday, 19th December (F 1619). Addendum t~ F 1581, tabled at the meeting on 19th December, (F 1609). Yours falthhflly, H.B. GRICE, Secretary. j' ! EIICB. ! C C t_r CT

.° TOBACCO RESEARCH Telephone : 01-828 2041 Tzlz 9".aura • Tobcmn. Loudou, S.W. 1. COUNCI L ~|eQ HOU~t, Slag Placz, London. S.W. 1. CONFIDENTIAL Dr. R. Comber. 16th December, 1968. Dear Sir, Secretary's Letter - S. B. S.G. 83 Copies of the following papers are enclosed for consideration at the S. B.S.G. meeting on Thursday, 19th December:- Agen& Item 1. Paper dated 9th December by Mr. I.R. Major on Mouse Transplant Project Progress Report (F 1567) 8 2. Progress Report for December 1968 from Mr. I.R. Major on Hyperplasia InvestigationS(F 1566) 9 3. Report dated 6th December from Dr. C.I. Ayres to the Tobacco Research Council on Skin-Thickening Test (F:I560) 9 For information Encs. . Paper by A.E. Williams on Methods for the Induction of Biologically Active Materials into or onto the surfaces of Animal Cells (F 1568) Report on the Mechanism of Carcinogenesis by the Neutral Fraction of Cigarette Smoke Condensate, from Dr. F.J.C. Roe and Dr. R. Peto (F 1557). Yours faithfully, H.B. Grice Secretary. , C) O tjJ

TOBACCO RESEARCH Te.lrpbo~e : 01-828 2041 T,.lcgeoms: Tobeo,,,,,. London. 5W.I. COUNCIL GJ£11 ]'~OUll4m, Slag Place, London. S.W.I. CONFIDENTIAL llth December. 1968. Dr. R. Comber, J iJ Dear Sir, Secretar~,'s Letter- 5.B.S.G. 82 Next Meeting The next meeting of the S.B.S.G. will be at 11.00 a.m. on Wednesday, 19tb December at Glen House. Luncheon will be avail able. Copies of the following papers are enclosed:- A[~enda Item i. Agenda (F 1550) 2. Final Analyses Fraction Experiments 1.1.3.1- 1.1.3.7. (F 1531) 3. : Final Analysis Experiment 1.1.4.1. "Anticarcinogenic Action of Nicotine" (F 1532) 4. Summary of Monthly Report XII/1968 (F 1551) 10 10 10 Yours sincerely, H.B. Grice Secretary. Enos. 0 C~ t.n O~

6 TOBACCO RESEARCH COUNCIL TeTcphone: TATE GALLERY ~o40 re/csrom,: TOBCOM, LONDON, 5.W.,. GLEN HOUSE, STAG PLACE, LONDON, S.W.i. 6th July, 1965, CONFIDENTIAL Dr. l.W. Hughes. Dear Dr. Hughes, Secretary's Letter - B.A.S.@. ~ I confirm that the following papers were sent to you yestarday unde~ the above Seeretary's Letter Number, and are far use ct the farthccming meeting:- (I) Note I~ Dr. Da~ on the Perugia Cezaeerence, (c 882). (2) Note by Drs. Tughan and Linasey on inhalation work by ~attelle, (C 875). (3) N@te by the Director on the instant oondenaate machine of ~.A.T. Hamburg, (C 7(~). (Z~) Letter from Nrs. Flaks, (C 870). Yours sincerely, S. F. Wilkins, for Secretary.

w" TOBACCO RESEARCH T, zizplsouz" 01-828 2041 Tziz~.,mu: Tobco~, Lo~o.. S.W. 1. COUNCIL G|e[~ House, S~acj Place, London. S.W. 1. 22rid November. 1968. CONFIDENTIAL Dr. R. Comber, Dear Sir, Secretary's Letter - S.B.S.G. 80 Copies of the following papers are enclosed:- i. Notes on the joint meeting of the Skin Bioassay Study Group and Statistical Study Group held on IZth November. (F 1420) . Relevance of extra-mural research projects to T. S. C. and Study Groups at 1st October, 1968 (F 1419). Yours faithfully, H.B. Grice Sec retary. J t / / Enos. ~J~ C~

TOBACCO RESEARCH T.k'pb~e : 01-828 2041 Tz.leg'ran~: Tobem., London, S.W.I. COUNCI L Glen House. Slag Place, London, S.W'. I. CONFIDENTIAL Dr. R. Comber, 14th November, 1968. Dear Sir, Secretary's Letter- S.B.S.G. 79 Copies of the following papers are enclosed:- 1. A Study of the Comparative Carcinogenicity of Cigarette and Cigar Smoke Condensate on Mouse Skin, by Dr. R.F. Davies and Dr. T.D. Day (F 1310). The paper was considered by T.S.C. on 7th November and will be considered by the E.C. on . 20th November. 2. List of reprints of papers received from Wissenscaftliche Forschungsstelle(F 1377). Yours flithfully, H.B. Grice Secretary. EDCB. C~ co

TOBACCO RESEARCH T~z: 01-828 2041 T..leg.ami: Tobeom, London, S.W, I. COUNCIL Glen Hoall4~, Slag PIacz, London. S.W.I. CONFIDENTIAL Dr. R. Comber, 30th October, 1968. lI /' Dear Sir, Secretary's Letter- S.S.G. 226 S.B.S.G. 78 The postponed joint meeting of the S. B, S.G. and S. S.G. has now been arranged for Tuesday, 12th November at 11.00 a.m. at these offices. Luncheon will be avaUable. The terms of reference for the meeting have been circulated (F 814). I now enclose the following papers for consideration at the meeting:- o Paper by Mr. P.N. Lee on the re-analysls of the main HarrogKte experiment at 48,64,80, 96,112 and 128 weeks qn standardised data (F 1321) . Note on screening tests for Agricultural Chemicals (F 1015) I Yours faithfully, H. B. Grlce, Secretary. Enos: C~ (_rl

• • t o, , . ' . • . -. •, o" , TOBACCO RESEARCH COUNCIL T~e: 01-828 2041 TalcS: Tobeem.Lo=Jon. S.W.I. Gten House. Sta9 Ptar.~, London, S.W. I. CONFIDENTIAL Dr. R. Comber. 18th October, 1968. ,/ I' Dear Sir, Secretary's Letter- S.B.S.G. 77 Coptes of the following papers are enclosed:- 1. Codification of Experimental Products as at 3rd October 1968 (F 1158) 2. Notes dated 7th October by the Director on a meet~ on 7th October to discuss Lysosomes (F 1215) Yours faithfully, H.B. Grice, Secretary. Encs:

TOBACCO RESEARCH T,d~phone: 01-828 2041 T,,h~g,~m=: Toheo~. Lo~ou, S.W. 1 COUNCIL Glen House. Slag Place. London, S.W~. 1. 2rid October, 1968. Dear Sir, S_ec. retary's Letter- S.B.S.G. 76 Copies of the following papers are enclosed:- I. Minutes of the 15th meeting of the S.B.S.G. held on Tuesday 24th September (F 1132). 2. A synopsis of alternations made to the paper "A study of the c olnparative earcinogenicity of cigarette and cigar smoke condensate on mouse skin" (F 941) (F 1146). , t Completed version of the above mentioned report by Dr. R.F. Davies andDr. T.D. Day (F 1147). Yours faithfully, H.B. Grice Secretary. EQCB. C C

° TOBACCO RESEARCH Telephone: 01-828 2041 T~l.~-lm.: Tobe--,.LozMon. 5.%.I. COU NCI L Glen HO¢IIN~, Slag Place, London, S.W.I. CONFIDENTIAL 17th September, 1968. Dr. R. Comber, // I Dear Sir, Secretary's Letter - S.B.S.G. 75 Next Meeting The next meeting of the S.B.S.G. will be at 11.00 a.m. on Tuesday 24th September at Glen House. Luncheon will be available. Copies of the following papers are enclosed for consideration:- i. 2. . . Agenda Rem 8 9 Agenda (F 1066) Tissue Culture Progress Report for September 1968 from Miss Yates (F 1081) Hyperplasia Investigation Progress Report for September 1968 from Mr. I.R. Major (F 1082) Paper by J.V. Frei and P. Stephens on 'Prhe Correlation of Promotion of Tumour Growth and of Induction of Hyperplasia in Epidermal Two-Stage Carcinogenesis" ( F 579) Yours faithluUy, H.B. Grice Secretary. 13 (f) EQcs. O C~

.o TOBACCO RESEARCH Telrphone : 01-828 2041 Tel-, ~: Tobeom. London. S.W.I. COUNCIL Glen House, Slag Placz. London. S:W. 1. lOth September, 1968. CONFIDENTIAL Dr. R. Comber, Dear Sir, Secretary's Letter - S. B.S.G. 74 Copies of the following papers are enclosed:- i. . Paper dated 23rd August from Imperial with proposals for research on Comparison of Tobacco Growths (F 964). Paper dated 27th August from Mr. W.S. Paige on Harrogate Mouse Skin Experiment Age Standardlsation (F 1013), Yours faithfully, H.B. Grice Secretary. Encs. O C~

TOBACCO RESEARCH T~hone : 01-828 2041 T,,.I e ~: Tobecm. Lom:lon. S .'~. 1. COU NCI L ~-~en ]['~Oqg4~. S~ag Placz. London, S.W. 1. CONFIDENTIAL Dr. R. Comber. 30th August, 1968. Dear Sir, Secretary's Letter - S. B. S.G. 73 Joint Meeting of S.B.S.G. and S.S.G. I have to advise you that the Statistical Study Group have asked that the Joint meeting of S. S.G. and S. B. S.G. on Tuesday, 10th September should be postponed until Mr. P.N. Lee has completed an age-standardised analysis of the main Harrog.ate experiment at the four time periods 80, 104, 116 and 128 weeks. A new date for the me~tlng will be arranged as soon as possible. Papers for Information 1. Paper by Drs. R.F. Davies and T.D. Day entitled "A study of the Comparative Carcinogenlclty of cigarette and cigar smoke condensate on mouse skin" (F 941) D Paper dated 28th August by Dr. J.K. Whitehead on the loss o~ biological activity in the maln "fractionatlon scheme (F 988) Encs: Yours faithfully, H.B. Grice, , o - ,. , ...; -. ,". .- , ~ .

TOBACCO RESEARCH T, depbone: 01-828 2041 TH* ~" Tobcom. I on, ton. S.W. 1. COUNCIL GIe. House. ~a9 Place, London. S.W. 1. CONFIDENTIAL 15th August, 1968. Dr. R. Comber, Dear Sir, Secretary's Letter - S. B. S.G. 72 Copies of the following papers are enclosed:- 1. Note dated 5th August from Dr. K. Rothwell with attached chart of Smoke Condensate Fractionation Schemes (F 891) This is a revised version of F 781. 2. Paper by Dr. Robin Davies on the possible use of the rabbit in ~kin painting experiments (F 913). Yours faithfully, H.B. Grice Secretary. Encs. CD "-,,u

TOBACCO RESEARCH T~e: 01-828 2041 Te.I. 9'eemw: Tolbeom. Lomdon. $.W. 1. COUNCIL Glen Hough, Slag Place, London. S.W 1. CONFIDENTIA L Dr. 1t. Comber. • xi August, 1968. Dear Sir, Secretary's Letter- S.B.S.G. 71 A copy of the following paper is enclosed :- / ¢ t 1. Note by Dr. H. Gaiseh to the Chairman of S. B.S.G. - July 1968 (F 859). ./ It has been decided that the joint meeting of the S.S.G. and S. B.S.G. to consider the termination and design of biological experiments (see Terms of 11eference F 814) will be held at these offices at 10.45 a.m. on Tue~lay, 10th September, 1968. Yours faithfully, H.B. G111CE, Secretary. Enc. O

TOBACCO RESEARCH Telephone: 01-825 2041 Tz].e 9'~am, s: Tobeom.London. S.W.1. COUNCIL Glen House, SZag Place. London, S.W. 1. C ONFIDENTIA L Dr. R. Comber, 29th July, 1968. Dear Sir, Secretary's Letter- S.B.S.G. 70 Copies of the following papers are enclosed:- 1. Figure 1 of document F 763, circulated with Secretary's Letter S.B.S.G. 67. 2. Paper dated 19th July from Mr. P.N. Lee entitled "A Further Estimate of the Proportion of the Tumorigenicity of Cigarette Smoke Condensate caused by its Benzpyrene Content" (F 837) 3. Paper dated 26th July from Mr. P.N. iee entitled "Analyses of the Main Experiment 1.1.1.1. at 80, 104, 116 and 128 weeks'(F 843) Yours faithfully, H.B. Grlce, : Secretary. Encs. M C~ (Jl

B • s TOBACCO RESEARCH COUNCIL Tckphone : 01-828 2041 TdegPoms: Tobeom. London. S ~ I Glen Hour, $Ia9 Place, London. S.W.I. CONFIDENTIAL 22rid July, 1968. Dr. R. Comber, Dear Sir, Secretary's Letter - S.B.S.G. 69 Copies of the following papers are enclosed:- 1. Codification of Experimental Products at at 19th July 1968 (F 808) 2. Revised Terms of Reference for a Joint meeting ofthe S.B.S.G. and S.S.G. (F 814) Yours fa/thfu~y, H.B. Gr/ce, Sec~dtary. Encs: t t I 2 / m 0 CD t.,4 t.m "-,4 (DO

TOBACCO RESEARCH Teledyne: 01-828 2041 Td,9~-m~: Tobcom.Lo~lon. S.~. 1- COUNCIL G]e.IB House, Sla9 Placz, London. S.W !, CONFIDENTIAL Dr. R. Comber, 17th July, 1968. Dear Sir, Secretaryts Letter- S.B.S.G. 68 Copies of the following papers are enclosed:- 1. Chart of Smoke Condensate Fracttonation Schemes at BarroEate (F 781) Amendment to the Minutes uf the 14th Meeting of the S. B. S.G. document F 687 (F 785). o, Yours faithfully, H.B. Grice, Secretary. EDcs. BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Te.k, phone: 01-828 2041 Te.I, ¢Se~m~: Tobeom. Lom:l on. S .W. 1. G|el~ House. Slag Place, London. S.W.I. CONFIDENTIAL 10th July, 1968. Dr. R. Comber, Dear Sir, Secretary's Letter - S.B.S.G. 67 Copies of the following papers are enclosed:- 1. Terms of Reference for a jo'.mt meeting between S.B.S.G. and S.S.G. (F 754) 2. Paper from Mr. P. Cross on Analysis of Skin • ~" Painting Experiments (F 763) Yours falthh~y, H.B. Gr~ne Secretary. / 0 / / EncB: a O OD O BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH Tekpbone : 01-828 2041 Talzgr.am=: Tobe~.London. 5.W.1. COUNCIL GJem HOU~o Sta9 Place, London. S.W. 1. CONFIDENTIA L Dr. R. Comber . 28th June, 1968. Dear Sir, Secretary,s Letter- S.B.S.G. 66 Copies of the following papers are enclosed:- I, Notes by Mr. W.S. Paige on a visit on May 29th to the Chester Beatty Cancer Research ]~mtltute to discuss with Dr. F.J.C. Roe the analysis of the Planning Committee Experiment ~ F 715) o Preliminary report dated 26th June by Dr. R.F. Davies on the Cigar Experiment (F 717) ! Yours fLtthfully, H.B. Grioe, Secretary. Ellcs: U- O= m BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH T=i=pi==ae : 01o$28 2041 T,.legt.a=w: Tobeom, London, S.W.I. COUNCIL Glzn House, Slag Placz, London. S.W.I. CONFIDENTIAL 24th June, 1968. Dr. R. Comber, / t Dear Sir, Secretary's Letter - S. B,S.G. 65 Copies of the following papers are enclosed:- 1. Minutes of the 14th meeting of the S.B.S.G. held on Wednesday 12th june (F 687) 2. Terms of Reference for the Technical and Scientific Committee (F 694) (F 588 revised) 3. Terms of Reference for all Study Groups (F 695) Yours faithfully, H.B. Grtce Secretary. EDCS. <:D CD t~ m tJ'l CO BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH T.~phonz 01-828 2041 1"-1- 9,emM : Tobeom. London. S.W.I. COUNCIL GJ£1~ House, Slag Place. London. $3~. 1. CONFIDENTIAL Dr. R. Comber. 18th June, 1968. Dear Sir, .Secretary's Letter - S.B.S.G. 64 Copies of the following papers are enclosed:- 1. Paper dated llth April from Mr. W.S. Paige on Harrogate Mouse Skin Experiments Age Standardisation (F 419) 2. Paper dated 25th April from Mr. P. Cross on Harrogate Mouse Skin Experiments Age Standardisation (F 457) 3. Paper dated 22rid April from Mr. P.N. Lee on Harrogate Mouse Skin Experiments Age Standardisation (F 521) 4. Memorandum dated 4th June to Dr. D.G. Felton from Dr. R. Comber of B-A.T. concerning age standardisation experiments (F 624) 5. l~aper dated 28th May on Statistical analysis of mouse skin painting results with special reference to age standardisation (F 589) Yours faithfuUy, H.B. Grice Secretary. Enos. O CD Co BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tzlzpiwne : 01-828 2041 T, r i,9,rams: Tobeom.London. S WI. G|en Hou~, Slag Place. London. S.W.I. CONFIDENTIAL Dr. R. Comber, 5th June, 1968. / t /" Dear Sir, Secretary's Letter- S.B.S.G. 63 Next Meeting The next meeting of the S.B.S.G. at the Harrogate Laboratories. Copies of the following papers are enclosed for consideration:- . 2. . will be at 9.30 a.m. on Wednesday, 12th June .Agenda Item 12 13 Encs. Agenda (F 616) Terms of Reference of the Technical and Scientific Committee: and all Study Groups (F 588) Report to the T.R.C. from Prof. H. Smith on Methods for the hrtrcduction of Biologically Active Materials into or onto the Surfaces of Animal Cells (F 610). Yours faithfully, H.B. Grlce, Secretary. O L~ BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T~q~mnz: 01-828 2041 T,,,lz~: Tobeom. Lo~on. S W. I. G~Cn HoEIs4~, Slag Place, London. S.W.I. CONFIDENTIA L Dr. R. Comber, 27th May, 1968. Dear Sir, Secretary's Letter- S.B.S.G. 62 Copies of the foUowtng papers are enclosed:- . Paper dated 22nd May from Mr. I.R. Major on Hyperplasia Investigations Progress Report, June 1968 (F 561). ° Paper dated 22nd May from Mr. I.R. Major on Tissue Transplant Investigations Progress Report ~ June 1968 (F 562). . Paper dated 22nd May from Miss S. Yates on Tissue Culture Progress Report - June 1968 (F 563). Enos. Yours faithfully, H.B. Grice, Secretary. C:D tJ'1 C3D t./1 BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telephone : 01-828 2041 Tel+ 9~ams ~ Tobeom. Lond on. S.W. 1. Glen Hour° ~og PIoc¢, London. S.W. 1. CONFIDENTIAL Dr. R. Comber, 7th May, 1968. Dear Dr. Comber, Secretary's Letter- S.B.S.G. 61 Copies of the following papers are enclosech- 1. Paper dated 25th April from Gallaher Ltd., on Analysis of Mouse Painting Experiments (F 456). 2. Paper dated 3rd May by the Director on Planning Committee Experiment - Analysis of Skin Painting Tests (F 481). 3. Paper from Mr. P.N. Lee on Main Experiment Tumour Sites (F 494). / / Yours sincerely, S. Byrd (Mrs) for Secretary. Enos. C~ C~ CO C~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tzlzpboee: 01-828 2041 T,.] egs.aaw: Tobcom. London. S.W.I. G~e~ 'Hous4~, Slag Place. London, S.W.I. CONFIDENTIAL 22nd April, 1968. Dr. R. Comber, [ / / Dear Dr. Comber, ..Secretary's Letter - S.B.S.G. 60 Copies of the following papers are enclosed:- lo Note dated 9th April by the Director on Re-orEanisatton of Technical and Scientific Committee and of Study Groups (F 413) t 3, Comlzleted HarroEate Skin Painting Experiments Actual Percentages of Tumour-BeartnE Animals (T.B.A.) (F 426) A note by Sir Charles Ellis on a method used to form an early estimate of the probable outcome of a bio-assay experiment (F 431) Yours sincerely, S. Byrd (Mrs) for Secretary. EDCS. I O CD t.n CO BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T=k3~=oae : 01-828 2041 Tdeff~=~: Tobeom, LozKlon. S,W. 1, Slag Pla~, London, S.W.I. CONFIDENTIAL 9th April, 1968. Dr. R. Comber, Dear Dr. Comber, Secretary's Letter- S.B.S.G. 59 A copy of the following paper is enclosed:- Completed Harrogate Skin Painting Experiments, Age-Standardised and Actual Percentages of Tumour-Bearlng Animals (T. B.A. ) (F 294). Yours sincerely, .. s. Byrd (Mrs.) for Secretary. E~. 0 0 t.n CxD CO BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T~e : 01-828 2041 T,.lz 9,.onw- Tobe-,-,, Loudou. S.W 1. G|tn ]['~OtlS4~ Slag Place. London. S.W. 1. CONFIDENTIAL 20th March, 1968. Dr. R. Comber, Dear Dr. Comber, Secretary's Letter - S.B.S.G. 58 A copy of the Minutes of the I3th meeting of the Skin Bio-Assay Study Group held on 13th March is enclosed (F 295) Yours sincerely, S. Byrd (Mrs) for Secretary. Enc: / t m CD O CO BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tzk, pho=e: 01-828 2041 Tdeg~.m~: Tobeom. London. S.W.I. CONFIDENTIAL GI~ Hour, Slag Place. London. S.W. 1. 7th March, 1968. Dr. R. Comber, Dear Dr. Comber, Secretary's Letter- S.B.S.G. 57 I Next Meeting The next meeting of the S.B.S.G. will be at 11 a.m. on Wednesday 13th March at Glen House. Luncheon will be available. Copies of the following papers are enclosed for consideration:- i. Agencl- (F 2,48) 2. ° Paper dated 5th January from Dr. A.J. Ltndsey on Reporting of Cigarette Smoke Analysis (F 45) Paper dated 15th February from Mr. P.N. Lee on The Cigar Experiment i. 1.8.2. (F 170) Agenda Item 10 10 Encs. Yours sincerely. S. Byrd ~Mre) for Secretary. d CD C~ 0 BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Te~n,e: 01-828 2041 Tzle~msw Tobe~,Londou. S Wl (~tn Hou54~, Stag Placz, London. S.W.t. CONFIDENTIAL 6th March. 1968. Dr. R. Comber. I" ° / Dear Dr. Comber, Secretary's Letter- $.B.S.G. 56 Copies of the following papers are enclosed:- 1. Report dated 29th February from Miss S. Yates on Tissue Culture, December 1967-February 1968 (F 219) 2. Progress report, March 1968 from Mr. I.R. Major on Hyperplasia Investigations (F 220) Yours sincerely, S. Byrd (Mrs.) for Secretary. Encs. BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T~ephoge." 01-828 2041 T~s~: Tobeom. Lo~lon. S.WI. GIzD Houge, Stag Placz. London. S.W. 1. CONFIDENTIAL Dr. R. Comber, 25th January, 1968. Dear Dr. Comber, Secretary's Letter - S. B.S. G 55 A copy of the following paper Ls enclosed:- Paper dated 19th January on Lung Cancer and Cigar Smoking that has been referred to the Executive Committee by T. S.C. (F 64 (F 27 Revised). Yours sincerely, S. Byrd (Mrs.) for Secretary. Eric, CD CD ,.O r~O BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tekphone: 01-828 2041 Tele ~r~ms: Tol~om, London. S.W. 1. (~eB HOUSl4~, Slag Place. London. S+W. I, CONFIDENTIAL 19th December, 1967. Dr. R. Comber, Dear Dr, Comber, Secretary's Letter - S. B. S.G. 54 Copies of the following papers are enclosed:- 1. Minutes of the 12th Meeting of the S. B. S.G. held on Thursday 7th December (E 1660) 2. Paper from Carreras Ltd. on Microbiological Content of Tobacco Smoke (E 1662) Yours sincerely, / ~.p.s. Sy~d (Mrs) for Secretary. EIIcs. CD 0 BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tck'phon® : 01-828 2041 Te~.9~m: Tobcom, London. 5.W.I. Glen House. Slag Place, London. S.W.I. CONFIDENTIAL 29th November, 1967. DR. R. Comber, /' Dear Dr. Comber, Secretary's Letter - S. B. S.G. 52 Next Meeting The next meeting of the S.B.S.G. will be held at 11.00 a.m. on Thursday 7th December at Gallaher Ltd., Granite House. Copies of the following papers are enclosed for consideration:- Agenda Item i. Agenda (E 1505) 2. Extract from Progress Report for October 1967 (E 1349) from the T. R.C. Laboratories Harrcgate (~ 1510) 5 3. Note dated 22nd November from Dr. R.F. Davies requesting authorization for purchase of mouse boxes (E 1491) 6 4. Paper from T. R.C. Laboratories on Capillary Press Experiment (E 1504) 7 5. Letter dated 29th August to Dr. Lindsey from Dr. H. Gaisch (E 1506) 10 6. Extract from Notes on Agenda (E 1280) of the 118th meeting of the E.C. held on Thursday 5th October (E 1507) 12 7. Paper dated 18th October on Harrogate Research Programme Proposals (E 1341) 12 Cont'd ... CD O --q. ,,D BATCo document for Legal Services : Health Canada 17 May 1999

, -2- Paper dated 3rd November by the Director on objectives of current and proposed product research at Harrogate (E 1393) Agenda Item 12 Yours sincerely, S. Byrd (Mrs) for Secretary. Enos. .7 i I CD 0 t.n ~D t.F BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH T,J~pho.z: 01-828 2041 T,..I~ 9',emJ: Tobeom. London. S.W. 1. COUNCIL Slag Placz. London. S.W. 1. CONFIDENTIAL 23rd November, 1967. Dr. R. Comber, Dear E]lc. Dr. Comber, Secretary's Letter - S. B. S.G. 51 Enclosed is a further report, dated 1st November, from Mr. P.N. Lee, on the four dosing regimes (E 1397). Yours sincerely, °, S. Byrd (Mrs.) for Secretary. t.j'l cr',, BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T~lqphone : 01-828 2041 Tcl~gl.am=: Tol~om, Lo~lon. S WI Gle8 House, ~ag Place, London. S.W. |. CONFIDENTIAL 1st November, 1967. Dr. R. Comber, Dear Dr. Comber. Secretary's Letter- S.B.S.G. 50 Next Meetin~. The next meeting of the S. B. S.G. will be held at 11 a.m. on Thursday, 7th December at Gallaher Ltd, Granite House. The Committee room at Glen House w~ll be in use by the Executive Committee at this time, and the.,Secretary is therefore grateful to Gallaher Ltd for their kind offer of hospitality. Copies of the following papers are enclosed:- 1. Paper by P.W. Brown and C.A. Fowler on the Toxicity of Tobacco Smoke Solutions to Proteus vulga.ris (E 1300) 2. Paper by, P.N. Lee on An Approximate estimate of the proportion of the tumorigenicity of cigarette smoke condensate caused by Benzpyrene content (E 1375). 3. Memorandum d~.ed 25th October from Dr. B.R. Davis on a visit to Hamburg (E 13 78). Yours sincerely, S. Byrd (Mrs) for Secretary. Enc s cZD w BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telephone : Tah~ Galler,tj 2,O41 Telegrurns: Tobeom. London. S.W.I. Glen },iOUlNe. Slag Pl,'.ce. London. S.W.I. c 01~ID~TIAL 28th July, 1967. Dr. R. Comber. Dear Dr. Comber, Secretary's Letter - S.B.$.@. ]~7 Copies ~ the following papers ere enclosed:- I. Co~icatimm of Experimental Products as at PJ+th July, 1967 (E 96A) 2. Miautes ~ the llth Meetiag of the S.B.S.G. hela on Tuesday 18th July (E 979) ~eurs slmcerely, s s~a (~,) for Secretary. hCa. / t 0 CD t.n ,-0 CO BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Telephone : To.tcGaUcr.tj Z041 Tele91~mm: Tobeom. London. S.WI COU NCI L Stag Place. London. S.W.I. lath July, 1967. Dear Dr. Comber, Secretaz~'s Letter - S.B.S.G. ~6 Next Meeting The next meeting of the Skin Bioassay Study Group on Tuesday, 18th July will now be held at Gallaher Ltd., Cannon Street, not at Glen House as previously arrange~. Copies of the following papers are encloee~:- 1. Paper entitle~ "Daily Skin-Painting Experiments" from Mr. P.N. Lee (E 890) 2. Notes iated 12th July 1967 by the Director on a meeting with Prof. R.D. Passey (E 902) To',~s sincerely, "f~ O l : s. s~( for Secretary. O O .....a. BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Te~l~e: T~GaI~ ~D4t Tzle~Is-mnm: Tobomn.LonJon. S.%~.1. C 0_RFID.~ IAL Dr. R. Comber. COUNCIL Stag Place, London. S.W. 1. 5th Ju~, 1967. I / Dear Dr. Comber, Secretaryls ~ette.r - S.B.S.G. ;+5 Next ~eet:ir~ Th9 next meeting of the S.B.S.G, will be held at 11 a.m. on ThursdAy, 18th July at Glen House, Luncheon will Be avail~ble. Copies of the following papers a~e enclcmed for oon~idsration:- Agenda Item t. Asen~ (~ 8~) 2. An Az~lyais by Mr. P.N. Lee of the StandArd Carcinogen Experiments 1.1.2.1. and 1.t.2.2. and Anomalies arising therefrom (2 865) 5 2- Paper entitled "Heasurements on puffs taken by human Smokers", by P.I. Adams, I.T. Co. Ltd. (E 7~1) 6 (a) ~. Paper entitled "Electron Spin Resonance-current Status" by Dr. R.F. Davies (E 840) 7 5. Extract from the ~iuutes of the 92nd Heeting of the T.S.C. (E 696) concernln8 Tobacco ~osaic Virus Skin Tests (E 856) 8 6. Extract from T.S.C. Minute- (2 696) concerning Tumour I>r~mot:~g effects of Cigarette Smoke Condensate (E 855) 9 7. Notes on Harrogate Capital Expenditure by Mr. D.R. Emery (2 860), with attached paper on Photo-micrographic equipment (E 8~9) 10 Packing of CIEarettes for Penar Tests:- Tins are no longer used and the cigarettes are now packed in 20's, put into 200 cartons, then in 6,000 boxesp ahrink-wrappe~ in polythene. s. (Mrs) for Secretary. Enos. O CD Cr~ O G BATCo document for Legal Services : Health Canada 17 May t999

TOBACCO RESEARCH Telephone: Tat'cGatl¢~ ZO41 Tel.,9~sm=: 3"ob©o~. Lo,don. S.W.I. COUNCIL G]en House 0 Stag Place, London. S.W. 1. CO~'IZ~f~IA~ 14.th June, 19(;7. Dr. R. Comber, Imar Dr. Comber, Secretary's Letter - S...B.S.@. Copies of the follow~ papers ars enclosed:- I. Extract fro= Journal of the National Cancer Institute voZuae 38 No. A (E 690). 2. An I.nte~.ia Report on the Differences between the ~our Dosing Reigt.=es byMr. P.N. Lee (E 738). ! I Yours sincerely, r~ s. syrs (ms) for Secretary. 0 s.mmD C~ 0 BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T,J~phone: Ta~ GaU~ 2041 Tellg~'mns: Tobcom. London. S.W~. 1. Glen House. Slag Place, London. S.W. 1. 23rd Msy, 1967. Dear Dr. Comber, SecretarT'e Letter - S.B.S.G. ~3 Copies of the following papers are enclosed:- 1, Notes by the Assistant Director on a Meetiz~ on Alkylating Substances held at Freiburg from Ath - 6th May (E 63A) 2. Minutes of the lOth Meeting of the S.B.S,G. held on Tuesday 9th May 19(;7 (E 65~.) Yours sincerely, s. Bm-a for Secretary. F~IM3I e CD O Qj~ Cr~ O P~D BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH Te~honz'. TateG~ P..041 TelegT~uz"." Tobeom. Lo~on. S.~.l. COU NCI L Glen 1-1ou.,e. Stag Place. London. S.M~. 1. 3rd May~ 1967. Dr. R. Comber. i I / Deer Dr. Comber, Next Meeting Secretary's Letter S.B.S.G. ~2 The next meeting of the S.B.S.G. will be held at 11 a.m. on Tuesday 9th May, at Glen House. Luncheon will be available. Copies of the following papers are enclosed for consideration:- Aienda Item 1. Agenda (E 553). ]~ctract from the Minutes of the 37th Meeting of the C.S.G. held on @th April (E 559). o Extract from the Minutes of the ~th Meeting of the T.S.C. held on 18th Januar~ (E 560). t0 s &o Six SElmA Reports of 1966 and Translations (~ 35o- R 3~6). 13 P a~er for Information Extract from Cancer Research dated March 1967 entitled "Penetration of (E~Za(~pyrene into the Skin of Mice with Inherited Cutaneous Abnormalities ~). Yours sincerely, ~c8. s. ~d (Mrs) for Secretary. ~j~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH Tak~e: Tal~G~l,=.~j 2041 Tzleg,,,asu : Tobco~.Londo-. S.W. 1. COUNCIL Glzm House, Stag Placz, London. S.W. 1. CO~"r~I~EZAL 21st April, 1967. Dr. R. Comber, Dear Dr. Comber, Secretary's Letter-S.B.S.G. At Copies of the followin6 papers are enclosed:- Letter dated 16th March, 1967 from Chairman of Stichting Sigarettenin~ustrie, enclosing application for patent from Dr. J. van Juls~ (E 329) o Notes by Dr.A.J. Lindsey dated l~PI;h April on a visit of the Skin Bioassay Study ~roup to the Wissenschaftliche Forchungsstelle im Verband Der Cigarettenindustrie, Hamburg on 1~th April, 1967 (E ~97) Yours sincerely, for Secretary. ENOS, O O t~4 J O BATCo document for Legal Services • Health Canada 17 May 1999

.... ~.j TOBACCO RESEARCH Tzlcgs.asm: Toi~mm. Lo~lom. S.W. 1. COUNCIL G~e.a Houle, ~a9 Place. London, S.W. 1. 1~th April, 1967. Dear Dr. Comber, Secretary's Letter - S.B.,,S.G.. 90 Copies of the following papers are enclose~:- 1. Report from Harrogate for March 1967 (E ~08) 2. Codification of Experimental Products as at 31st March 1967 (E ~.) / t ]RnCS: Yours sincerely, s. sy~d (Mr,) for Secretary. m O O tJ~ t~J Cr~ O BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH T=t=pl~=: 7a~ G°U=~ =O41 Telegram: Tobeom. LonJon. S W 1. COUNCIL C;]en HotJ~, Slug Place. London. S W 1 28¢h ]larch, 1967. Dr. R, Comber, DMrDr. Comber, $ecretarT'= Letter - S,B.S.G. 59 Next Meet:Lug It has been deo~dod t~t since there is ~nsu~icAent business to discuss on April 12th, the next mooting will ~e hol~ on Tuosday~y 9th. l~pers enalos,sd for, !nformat±on:- 1. P&p~r on ~ectron Sp~n Resonance, Pro6resa Report ZZ larch 1967, b7 z.~. Ma~or (s 333) 2. ~=tract from NAture dated 25th Xar=h 1967 on *.he "EfTeots of' Tobacoo Smoke on Lung Tissue &a neaaured by ~ectron Spin Resonance" (Z 357) 1routs ,inoar,~, for 8cetera.--y, ~r~cs: 0 BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH T, leFhone : Tare Gatler9 ZO4,I Teleej~-emm ~ Tobcom. London. S.'¢E. 1. COU NCi L (G|¢n House, Stag Prate, London. S.W. 1. C~F~qT-J~L 14.th March, 1967. Dr. -~. Comber. Dear Dr. Comber, Secretary's Letter- S.B.S.@. 3a I have pleasure in enclosing a copy of the Minutes of the ~th meeting of ~he Skin Bio-assay Stud~ &roup, held on 8th March, 1967. (E 2%). Yours sincerely, for Secretary. /I .0 ~C, O O m O BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH TeJ~phone: Ta~eGaller~ 2041 Tele~r~.u ~ Tobeom. London, S.W.I. COUNCIL GI¢- House. Slag Place, London. S.W.I. 1s¢ March, 1967. Dr. R. Comber, Dear Dr. Comber, Secretary's Letter - S.B.S.G. 32 The next S.B.S.G. meeting will be held st Glen House at 11 a.m. on Wednesday 8th March. Luncheon will be available. Copies of the following papers a~ e-close(1 for your consi~eration-- I. Agenda (E 253) A~enda Item 2. Paper on Mouse Paintiz~ experizents coaplete~ or ne.a~ng c~pletion st 1st March, 1967 (3 206) 8 3. Paper dated 13tJ~ January by Dr. A.J. Lindsey on The analysis of Mouse Skin Pai~¢i~ Experlaents Pa~r for Infor~tion:- Extract from Cancer EeBearch entitled The Reduction of the Tumorigenicity of Cigarette Smoke Condensate by Addition of Sodi~ Nitrate to Tobacco, by Hoffaan an~ ~r CE ~7) Yours sincere ~V, for 8e0retar'y. 0 BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Telephone : TotcGallcrxj 3041 T¢1¢ 9~r~: Tobeom. LonJon. S.W. 1. CO U NCI L G|en Hoctll4=, S~ag Placz. London. S.~. 1. 13th February', t %7. Dr. R. Comber, Dear Dr. Comber, SecretarT's Letter - S.B.S.G. 36 Copies of the followin~ papers are enclosed for your information:- I ) Report from Harrogate for January 1967 - Response to condensate - mice surviving an~ turnouts produced (E 159). 2) Amended Ninutes of the 8th S.B.S.G. meeting hold on January 12th (E 71 amended). 3) Note dated 10th February on allocation of mice for tb~ reconstituted sheet comparison experiments (E 183). .° Yours sincerely, S. Byrd ( for SecrsCary. / / / m CD 0 CD ~D BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH T~.l~e: To~ G~cj 2o41 T~.le g~-mm: To~. Lo~lon. S.W.I. C0HFIDE~TZAL Dr. ]t. Comber. COUNCIL G]eJ~ ]['louse, Slag P1ar.~, London. S.W.I. 2~-d ~anuaxT, 1967. ])eLl" ]ZI¢: Dr. Comber, Secretary's Letter - S.B, Sj.G. 35 I eaeloae the fol"lcmi~g paper for your information:- Minutes of the 8~h Skin Bio-assay 8tud~ Group Meeting hel~ on 12th Januaz-y, 1967 (~ 71) Tours aincerely, s. B~a Cur.) for Secretary. 0 m BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Tz, iz ~.uml: Tobcom. Londo,. S W. I. COUNCIL GIeD HouI~o Slag Placz, London, S.W. !. co~.~ Dr R. Comber. 5th January, 1967 / Dear Dr. Comber, Secretary's Letter - S.B.S.G, ~5, The next meeting of the Skin Bio-assay Study Group will be held at 11 a.m. on Thursday 12th January, at Glen House. Luncheon will be available. Copies of the following papers are enclosed for your consideration:- Azend~ Items 1. Agenda (E 21) e 3. Harro~ate Report for December 1966 (E 23) .f Extract from Minutes of the Statistical Sub-Committee meeting held on 7th December, (~ 25) 6 Report dated 3rd January, 1967 by Mr. I.R. Major on Electron Spin Resonance with copy of letter da~ed 2~rd December from Professor Commoner to Dr. Horsfield (E 24) 12 . Extract from Lancet, ~Ist December 1966 entitled "Mast cells and cancer in the skin of mice", by James F. Riley, (E 15) 13 ~nCS. Yours sincerely, s. B~a (~s) for Secz'etary. O O O', BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH TelepiKm¢: Tcd~Galle~ 2041 Tel¢~.mJ: To]~o~. London. 5.W.I. COU NCI L Glen l-loumeo Stag Placz. London. S.W.I. 28th ])ec~bez', 1966. Dr. R. Comber, Dear Dr. Comber, Secretary's Letter S..B.S.G. 33 A copy of a paper by the Assistant Director - Co~Lfication of experimental products, (D t575), is enclosed for your information. Yours sincerely, s. ~d (=rs.) -- for ~ecretary. Cr~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH Tclep~.e: TATE GALLERY 204., T.lcgr.m : TOBCOM. LONDON, S.W.I. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.L CO_NFZ~E~TZ~L Dr. R. Comber. 15th December, 1966. ! ; / DoI~ ~CS. Dr. Comber, Secretary's Letter. ,- B,B.B,C,. 32 Copies of the following papers are enclosed fc~ your information:- le 2~ w Minutes of the 7th Skin Bio-~ssay Study Group Meeting held on the 7th December (D 1558) Minutes ~ a meeting held on 24t~25th November at Glen House with Drs. Teber,Dontenwill and Ltp~ (D 15~o) Two sheets omitted from the ~arrogate Monthly Report for November (D 1515) which was tabled at the meeting held on 7th December. he Notes by the Assistant Directcr on a meeting on 12th December with Dr, T. Chouroulinkov concerning Research at VilleJuif (D 1567) B Extract from journal of the National Cancer Institute, November '1966 (I) 1568) Yours s~cerely, S. Byrd for Secretary. O O Cr~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tdep~r~: TATE GALLERY 1o4, Telegtan~: TOBCOM, LONDON, S.W, ,. GLEN HOUSE, STAG PLACE, LONDON, S.W.,. Ogm'ID~. 18t December, 1966. Dr. R. Comber, Dear Dr. Conber9 Secretary's Letter - S,B.S.G. 31 Copies of the followin8 papers are enclosed for your consideration at the next Skin Bio-assay Study Group Meetins:- le Supplementary Report by the Assistant Direc$or on the Tokyo Congress (D I~O) e o Progress Report by Mr. I.R. Kajor for December, 1966 on Electron Spln Resonance (D I~91) Report on E.S.R. of Rat Livers Treated with Butter Yellow from Dr. D.A. Horsfield (D 1A92) ~B Progress report far December 1966 by Mr. I.R. Major on Hyperplasia investigations (D 1493) ~e Report of a visit to Dr. A.F~ Powell at Mount Vernon ,Hospital on the Ist November by Nima S. Yates (D I;+9;+) Tours sincerely, s. Syrd (Mrs) for Seor etaA'y. IDCS. 0 0 o',, BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Ftlcp/umz. TATE GALLERY ze4.1 TelfSro,*,: TOBCOM, LONDON, $.W.z. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.,. Dr. R. Comber. 29~ Noveaber, 1966. Dear Dr. Comber, Seoret~/fe Letter - S,B.S.G. ~0 I co~¢~= that the next meet~a~g of the Skin Bio-aasay $t~l7 Group will be held at 9.30 a.a. on Wednesday, 7th Deo~mber at Harrogate. Copies of the follqrAng papers are enclosed for your consideration:- le 2. lgemda (D It~77) Letter dated ~th October fro= Dr. F.J.C. Roe with tables of the T~/T3 oarotuogeniotty cospariaon Tests (g 11~9) .AEenda item 10 Yours sincerely, for 8eoretaz7. 0 0 ¢.n BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO Tcltpho.t: TAT£ GALLERY 2o4t YelcSrast~ : TOBCOM, LONDON, S.W. ,. RESEARCH COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.l. 26th Octob.r, 1966. Dear Dr. Comber, Seoret ayy's Letter - S.B,S.@, 28 Copies of the follo~ing papers are enclosed for your information:- 1. Minutes of the 6th Skin Bio-assay Study @roup meeting held on 12th October (D 1309) 2. Notes ~ated 18th October by the Director on e Suggested mouse skin painting experinents, (D 1325) Note dato~ 19th October by the Secretary on P~pers for distribution (D 1312) Tours oinoere~, ," s. ~=~ (~a) / ' for Secretary. / IbnOS. L~ Cr~ BATCo document for Legal Services : Health Canada 17 May 1999

666£ ~elN LI. epeueo qJ, leeH : se0!~es leBe'l Joj ),ueLunoop o01v9 O0 m "-0 r,,,'D c~ q....,. "sm~ • ~e.zoeg .zo,; (,~) ~.~ .~ LG'Cezooul:e t,znoz uo t:Vwaczo,,,~ 'kO~T "(~9~t, (l) '.zoqo;oo q;;~t, ao 9u;Veoz "O*~'~'g eqo, ~e vpu~y ;rq; ,;o 9 WqT ,zepun aOTSU,ze~Traoo ..,co; '(0~-91,.'c.) eecT.£o, ;uo,zej.,~:p j:o zooosqo~ ~,z,; epsu eeo,.o,e.n~TO Jo~,seuopuoo .~o ~uT;ae; oq~. uo .mc~ld • ,To £~oo s 9=TioTouo m Z t2 'o'S'~'S .~ev;eq ;z0~n, vo*,oes '~CL=O~ "~<1 ,z.e([ "9%~ ~:eqo;oo qv9 • ~'~'S ' NOGNO"I '~3V~4 9v.tg '3SnOH 1,4a'I D • ",~'S 'NOONO'I 'laO3SO.L : sw~;,pl r~o[ A'tl3TIVD 3£¥/. : "u°'tJ)Pl "IIDNflOD HD}IV3~}I ODDYHO.L

TOBACCO RESEARCH COUNCIL / T~Jeph~a~: TATE GALLERY 2o41 Tekaeem : TOBCOM, LONDON, S.W.I. GLEN HOUSE, STAG PLACE, LONDON, S.W.t. IX-. R. Comber. 5th Octobtn', 1966. / ! Dear Dr. Co-bet, Se.cretaxT'8 Letter - S.B.S.;. 26 Next,, Meet ing Z have pleasure in enclosing the Aj:en, da (D 12~2) for the next $,B.S.G. Meeting to be held at 11 a.n. on Wednesday, 12th October at ~len House. Luncheon will be available, papers enclosed for consideration 1. Paper dated 16th September troR B-A.T. entitled 8odiuu filtrate loads& cigarettes, (D 1139) # Notes dated 3rd Oo¢ober by the Director concerning tobacco/air pollutant atudiea, (D 1238) 10 Paper for infornation The pape~by Dr. T.D. IbLy reportlnK the results of the first na£n ~rro~te EzWAahnt ha~ been approve& by the Exa~tive Cnaaittee an& 8ent to the ~ritiah Journal at Cancer to be oonai~ered for publication. Certain aaendaents ware made to D 113~, the last draft o~ ~he paper, an& copies of the aaended pages have been inoarpor&ted with D 1136 in this oi~ice, and I am now e,~closing the p~per (~ To~s sinoere~, s. s~a (~r~) ~'OX" Se (:x" eta.z'~r. 0 0 C~ ~0 BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH TelepI, m,e: TATE GALJ.ER¥ to41 TdeSrams : TOBCOM, LONDON, S.W.t. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.I. 2~ Sopt~ber, 1966. C ON'F ~El~l~ L~.T~ Dr. R. Comber. Des.r D~. Comber, Secretary's Letter - S.B.S.g. 25.+ Copies of the following papers are enclose~ for your information:- I • Notes dated 9th September by Dr. T.D. Day on the role of Condensation in the course of Chemical Carcinogenesis by Smoke, (D 1103) e Letter dated 19th September fro,,, Mr. W.$. Paige to the Director enclosing co~ente on the Day/ Paige paper, (D 1181) .; .~'A OS, + Yours sincerely, s. B~e (~e) for Secretary, w 0 0 LJJ Cr~ 0 BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO Tclcp~nt : TATE GALLERY 2o4z T*legroms: TOBCOM, LONDON, S.W. :. RESEARCH COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.I. CONF ZDEI4~ZAE 15th 8eptelber, 1966, Dr. R. Oowber. Dear Dr. Co~ber, Secretar7' s Letter - S.. B. S, G. 2~. I have pleasure in enclosing for your information a copy of the following:- 1 • Minutes of the 5th Meeting of the 8.3,S.@. held at 11.a.m, on 8th September,1966, at @len House• (D 1112). Yours sincerely, • for Secretary. / ~xl0. 0 CZD V~O BATCo document for Legal Services : Health Canada 17 May 1999

Z3 TOBACCO RESEARCH COUNCIL Telepke~: TATE GALLERY 204t 7eltSroms: TOBCOM, LONDON, S.W.=. GLEN HOUSE, STAG PLACE, LONDON, S.W.I. STRICTLY C01~FIIEI~IA~ Dr. R. Camber. 13th September, 1966. Dear Dr. Camber, Secretary's Letter S.S.C. 125 C.S.G. 85 R.S.G. 22 S.B.S.G. 23 1 I m I am enclosing a revised copy of the Day/Paige Paper (D 1057) for your infor~tion. I | ~0 Yours sCnoere3~, for Secretary. C~ C7~ BATCo document for Legal Services - Health Canada 17 May 1999

2l TOBACCO RESEARCH COUNCIL Telephone: TATE GALLERY 2o4, TcteSra~: TOBCOM, LONDON, S.W.I. GLEN HOUSE, STAG PLACE, LONDON, S.W.l. ~l 8ep~aber, 1966. Dr. ~. Comber. f / Dear Dr. Comber, 8eor~tarjr's Letter - S.B.8.&. 22 I hay8 pleuu.re in eaolosi~ oc~:l.os of the follo,,i~ Pal~rs fo~ oonsAderst£on at the aeeting of the Skin )io-~say Stud~ ;roup on 8th 8epteaber 1966:- ~. Paper 4ate~ 13th August oa B3"l:erplasia Zmmstiga~ions 2. Paper;dAted 18t 8epteaber on Electron 8pin bsonanoe b~ zr. z~ xajo~ (D 10As) 3. bpoz't ~te~ l st 8epteaber on Tissue Cu.l~e by ~,,. S. Tares (D 10~.9) Report dated 31st August on @ A 8 Eiorephotographio Equipment "by Dre J~(. Wh:Ltehoacl. CD 1050) 5. ~o~t ~ats~ ~lst August 1966 by Dr. ;.K. l~tteheaA on TestAn~ of ten.haste ~ T16 oi~ar~ttes CD to5~) ~. Notes by the Assistant DL~otor ~ Dr. ~ 1~tehea~ 4A~ea )1st ,A~gut on Testing of ~ba )Iolo~ioal Ao~Ivlty of 8exi-~olatiles in 24 bouP Co~enla~. (D I0~5) ~or Seo~tary. m CD BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tckpha~: TATE GALLEKY zo41 l'eitsrarns: TOBCOM, LONDON, S.W.l. GLEN HOUSE, STAG PLACE, LONDON, S.W.l. Joth Augm~, 1966. Dr. R. Comber, Dear Dr. Comber, 8ecre~azT"'s Letter - S.~.S.G. 21 I confirm that the next meeting of the Skin Bio-assay Study @roup will be hel~ at 11 a.~. on Thursday 8th Sep~e~erj 1966 at Glen House. Lm~cheon will be available. The Agen~ is enclosed, (D 1008). Yours sinoerQly, . s. ~ (~-s) for Seoretary. N O O cr~ BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Tdq~l~ac: TATE GALLERY 2o4.1 Tdesrams: TOBCOM, LONDON, S.W.I. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.i. CONFIDENTIAL Dr. R. Comber. Dear Dr. Comber, 10th August, 1966 Secretary's Letter - 8.BrS, G, 20 I have pleasure in enclosing for your information a copy of the report from Dr. T.D.Day for July, 1966 - Response to condensate - mice surviving and turnouts produced (D 961). / Enc. ! Yours sincerely for Secretary. CD Cr~ r~D Q~ BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tdcpboac: TATE GALLERY 2~.s TcleSraa. : TOBCOM, LONDON, S.W.I. GLEN HOUSE, STAG PLACE, LONDON, S.W.I. 29th July, 1966. CONFIDENTIAL ~r. R. Comber. Dear Dr. Comber, Secretary's Letter - S.B.S.~. 19 Copies of the following papers are enclosed fur your information:- i. eLFer ~ R.~. aAcharason ~ed 2~th ~ay, 1966 antltled " The 5urfaoe Tensic~ And Viscosity of Solutions of Smoke Condensate" (D 711) 2. Repart by Eastman on Biological and Chemical Studies of Cigarette Smoke Condensates (D 882). Members will note that T.R.C. is asked not to publish the report or refer to the research in publication. 3. Notes dated 21st July, 1966 by the Assistant Directer on Blend B and Folie B. (D 91 7)-- Yours sincerely, 3 S. ~yrd (~s~)" for Secretary. ~cs ° CD N cr~ cr~ BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Td~: TATE GALLERY 2-41 TdeSrQms: TOBCOM, LONDON, S.W.I. COUNCIL GLEN HOUSE,- STAG PLACE, LONDON, S.W.x. C O~ ~EFFJ:AL 22m:l 3uly, 1966 Dr. R. Comber. Dear Dr. Comber, Secretar:~'s Letter - S.B.S.G, 18 I am enclosing f~ your information a paper by Dr. T.D. Day an~ Mr. W.S. Paige on Carcinogenio Acti~ of Cigarette ~oke Condensate on io~, sk:m, (~ 886). Yours sincerely, . I ; f~ Secretary. 0 Cr~ r~D BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tdeptmae: TATE GALLERY 2041 Telesrem: TOBCOM, LONDON, S.W.l. CtYL~FI I~ITZAI., Dr. R. Comber. ~)oar GLEN HOUSE, STAG PLACE, LONDON, S.W.x. 13th July, i%6 Dr. Comber, Secretary' s Letter - $.B.S.G. 17 I am enclosing copies of the following papers for your information:- I. Minutes of the ~th Skin Bioassay Study . Group Meeting on 6th July, 1966, (D 863) 2. Membership List of Committees of T.R.C. at Ist July, 1966, (D 8AI). Yours sincerely, s. B~ (urs), for Secretary. 0 0 0% BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T¢lcpheee: TATE GALLERY.zo4.1 Tcl¢gra~a: TOBCOM, LONDON, S.W.l. GLEN HOUSE, STAG PLACE, LONDON, S.W.x. qo~n)m~z~ 1st July, 1966. Dr. R. Comber. Dear Dr. Comber, Secretary's Letter S.B.B.G, 16 I confirm that the next meeting of the Skin Bioassay Study Group will Be held at 11 a.m. on Wednesday, 6th July, 1966, at these ~$oea. Luncheon will be available. The following papers are enclose~ for consideration at the meeting:- : Agenda Items ,J f' I. Agenda, (D 827) 2. e Report on Hyperplasia work by Mr. I.R. Major, dated 29th June, 1964 (D 8~) ! Report on Tissue Culture by Hiss S.E. Yatee, dated 3Oth June, 1966, (D 825). Yours sincerely, S. Ryra, (~rs), for Secretary. Rn08. m O O L.,q C~ x,O BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telephe~: TATE GALLERY 2o+1 Ttltsr=~: TOBCOM, LONDON, S.W.z. GLEN HOUSE, STAG PLACE, LONDON,-S.W.l. l~th o,A~, 1966. Dear Dr. Comber, Secretar~'s.Lq~ter S.B.S.G. 15 I have pleasure in enclosing copies of the following papers for information:- / it 4" / ~OSe t0 J Minutes of the ~d Meeting of the S.B.S.G. on 9th June, 1966, (D 75o). Report from Dr. T.D. Day for May 1966 on Response to Condensate - Mice Surviving and ¢mnours Produeed~ (D 715). Yours sincerely, .Z4: 8.F. Wilkin ~, fcm Secretary. CD O ~J~ CY~ ~JJ BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tel~kea~: TATE GALLERY =o4t Tt/¢grems: TOBCOM, LONDON, S.W. =. GLEN HOUSE, STAG PLACE, LONDON, S.W.,. 3r~ J~e, 1966. Dr. R. Comber, Dear Dr. Comber, Secretary' s Letter S.B.S.@. 1;+ I have pleasure in enclosing two further l~pers for considaraCion at the S.B.S. @. meeting on 9th June: - 1) Note by Mr. I.L Major dated 2~ June 1966 on the Spare Mouse Po~lati: (D 706). 2) lqoCe by Mr. I.R. l~Jor dated Ist June 1966 on ~lectron Spin Resonance (D 705). Yours sincerely, 8.?. Wil~Jus, for SeoretazT. A~enaa I~u 9 1A O o o'x BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tel~lm.¢: TATE GALLERY 2e÷, Teiesremx: TOBCOM, LONDON, S.W.1. GLEN HOUSE, STAG PLACE, LONDON, S.W.t. De& r Dr. Coab~ . cre~ary' s ~etter - 8. B. S:_~. 13 I co,lira that the next aeetlng ~ the 8.B.8.~. will be hsla at II a.m. on Thursday, 9~h June, 1966 at these Offices. A llght luncheon will be served. The following ~pers for consideration at the aa. eting ars enclose~- 1. ,~.eJ (D 690). 2. Note by Dr. J.K. Whitehead dated 6th May, 1966 giving the report on progresa on the Instant c~a~ ~a~, (~ 6~). t / Yours sincerely, 8. F. W~d~e for So crstaxT. CD CD N BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH TelcpAeee: TATE GALLERY 2e41 Telteroms: TOBCOM, LONDON, S.W.,. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.t. 27~a. ]lay, 1966, Dear Dr. Comber, 8eorrt~rT~s I~M~r - 8.B.8.C,. 12 T ooxd~ ~ a report by Dr. A.J. Lix~Lsey on ~e secom~ draft of Dr. Day's paper was sent direct to Members by Dr. Lindsey, (D 613). I have pleasure in enclosing copies of the following papers for information:- 1. Note by the Assistant Di~ctor dated 2Ath May, 1966 on numbers of mice at Harrogate, (D fi58). 2. Note by Dr. J.K. Whitehead dated 20th May, 1~ on changes in dosing procedures for souse painting ezpez~eB~s, (D 667)° Tours siaoerel7, 8.F. ~Alkins, for Secretary. 'R]3,Ce. 0 0 O"x BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T,Jcp~M: TATE GALLFRY I~M~J Telrsmm: TOBCOM, LONDON, $.W.s. COFI~DEh'~I/E, GLEN HOUSE, STAG PLACE, LONDON, S.W.I. llth May, 1966, Dr. R. Comber. Dear Dr. Comber, Secretary's Letter - S.3.S.@. 11 Draft Report by Dr. T.D. Day We enclose with this letter a copy of the second draft (D 577) of Dr. Day's paper on the main experiment at Harrogate, including a statistical appendix by Mr. W.S. Paige. This will be discussed by the Technical Sub-Committee on Tuesday, 17th May, and since the work is the responsibility of the S.B.S.G., Dr. Lindsey would be grateful if you would read the report quickly and let him know by Friday or Monday whether you have any comments. Dr. Lindsey will then consider whether it will be necessary to hold an early special meeting of the S.B.S.G. to consider the report further. Also enclosed is a copy of a report from Dr. T.D. Day for April, 1966 on Response to Condensate - Mice Surviving and Ttuaours Produced, (D 602). Yours sincerely, S. F. Wllkins for Secretary. t CD 0 BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Td~: TATF GALLERY 2a+l T, Irg~,m: TOBCOM, LONDON, $.W. ,. GLEN HOUSE, STAG PLACE, LONDON, S.W.x. 26th April, 1966. CG~I~NTIAL Dr. R. Comber. Dear Dr. Comb ar, Secretary's Letter - S.3.S.G. 10 I have pleasure in enclosing copies of the following papers for information:- 1. Minutes of the 2nd Meeting of the S.B.S.@. on 9th April, 1966, (n ~.a). 2. Note by Dr. J.K. Whitehead giving the Smoking Schedule as at 14th April, 1966, (D 5~I). 3. Note by Dr. 3.K. Whitehea~ giving the Mouse Palntin~ Sctlecl'ml~-~ i~or April, 1966, (n 542). Yours slacereiy, S.F. Wilkins far Secretary. ~nOS. 0 0 BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telephone: TATF. GALLERY 2o4.1 TcleSram, : TOBCOM, LONDON, S.W.i. GLEN HOUSE, STAG PLACE, LONDON, S.W.:. CO~FI~ERTIAL l~.'~b April, 1966. Dr. R. C omb er. Dear Dr. Comber, Secreta~'s Letter - 8.B.S.G. The followir~ papers are for consideration at the next meeting of the S.B.S.G. on 19thApril, 1966:- A~nda item Io :,.. ~,~,. ~ 2, Q A copy of Dr. T.~Day's paper on the Harrogate results. (D ~93). Reference is made in this paper by Dr. Day to results produced by a computer. This section has not yet been prepared and to this extent the paper is incomplete. Statistics!Analysis o£ the First Harrogate Skin Painting Equipment prepared by Mr. W.8. Pai6e, (D ~7). The first draft of the T.R.C. Review of Activities, ~963-66, (n ~o). 4 5 / I" °, Yours sincerely, S.F. Wilkins, for Secretary. ~ncs ° 0 CD Cr~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telepl~ne: TATE GALLERY 2o,,I.J Telesrem,: TOHCOM. LONDON, S.W.I. GLEN HOUSE, STAG PLACE, LONDON, S.W.~. C ONFII~TIAL Dr. R. Ccmber. 13th April, 1966. Dear Or. :ozb~r P 3ecretar~'s Letter- $.B.S.G. 8 I confirm that the next meeting of the S.B.S.@. will be held at 11.a.m. on TuesdAy, 19th April, 1966 at these Offices. A light luncheon will be served. The following papers for consideration at the meeting are enclosed:- Other papers for the A~en~ - (D ~). 2. Note by Dr. 3.K. Whitehead dated lOth larch, 1966 on the Instant Condensate Machine, (D ~). 3. Note by the Director dated 9th February, 1966 on the allocation of January mice, (D 197). 4. Note by Dr. J.K. Whitehead dated @th Karch, 1966 on the Smoking Schedule, (D 326). 5. Copy of a letter to Dr. J.K. Whitehead dated 12th April, 1966 from Mr. W.S. Paige on April 1966 House Painting, (D ~$9). 6. Note by Hr. B. Moriarty of the Harrogate Unit dated 16thNmroh on the Cigarette Stock an~ Cold Store, (D~03). meeting will be sent later. Yours sincerely, JC, S.F. Wilkins for Secretary. Enca CX~ Cr~ BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Te/tp/mw: TATE GALLERY 2~i TeleSrams: TOBCOM, LONDON, S.W.~. GLEN HOUSE, STAG PLACE, LONDON, S.W.t. 7thApril, 1966. Dear Dr. Comber, Secre,taA'~'s Letter - S.3.S.;. 7 I have pleasure in enclosing a copy of the first dA-aft of the Appendix to the T.R.C. Review of Activities for 1963-66, (D A61). Yours slneere1~, 8. F. Irilkins for 8eere'~ary. ! °. • . -, "° . ::; .... "..-" -. . / • B 0 0 '41mmm.-- t.,,; O~ Co BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL TciclN~mc: TATE GALLERY 2e4J rel,6mm: TOBCOM, LONDON. $.W.I. GLEN HOUSE, STAG PLACE, LONDON, S,W.L _ i 25th Xar~h, 1966. Dr. R. Comber, Dear Dr, Comber, SecretarT's Letter - S.B.S.~.. 6. I have pleasure in enclcair~ copies of the following papers for information:- I. Note by Dr. J.L W~itehead dated 21st Maroh, 1966 entitleR "A preliminary assessment of the Mouse Painting Experiments now being undertaken of Smoke Condensate l'raetions", (D ~I 5) • 2. Paper By Mr. I.R. Major of the EazTogate Research Uni% ~ated ,~ 6th March, 1966 entitled "Pro schedule of the Low Term A~elng Xxperlae=t', (D 381). 3. Report receiver from the Trench To~aeoo Monopoly on resear@h carried out durin~ 1965 within the fraaew~k of taak~ eubsldisea by the S.E.I.T.A. un~Dr Prof. E. Truhautp (D ~o). f m Your, aln~ly, S.IP. T11klns f~ Seore~ary. ~nO8. 0 0 ~C BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH TelrpIN~r~: TATE GALLERY 2e4, Telcl~mt: TOBCOM, LONDON, $.WJ. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.,. 17th ~uPch, 1966. ! / Dear Dr. Comber, Secretar7' s Letter S.3,S.@. 5 I have pleasure in enclosing copies of the following papers for Infor=ation: - 1, Minutes of the 1st Meetin8 of the S.B.$.@. on 9th March, 1966(D 361)o 2. Report f~o~ Dr. TeD. Day for February 1966 on Response to Con~ens~tes - Mice Surviving and T~ou~s Produced (D 360). 3. Report from the Huntingdon Research Centre dsted 28th Yebruaryj 1966 on the Production Performance of Wlstar ra~s, received fro, the Hiddlesex Hospital (D 35~), Note by Dr. V.D, Tughan dated 11th Marchp 1966 on the Hyperpl~l& Test (D 371 ). 5. Copy of letter from Dr. T,D. Day dated 11~h Harchj 19(;6 to Dr. R.D. Carpenter of Philip MolTis L-.o. on the ~pe~luin Test (D 368). 6. Copy of a letter from Dr. T.D. Day ~ted 15t.h Haz'oh, 1966 ¢O the Assistant Direotor on spare mice at Harro6ate (D 377). t Yours sincerely, S.F. Wllkins, for 3eeretary. " ~"'::i:::::..~:':~ i.. ";::. " (.,N • .- ""-.-.: . :. ............. ~ ......... G,J • 0",, # • :,- .... ""° .... . " C:73 .. ." • • I BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL 7tJeph~; TATE GAU.ERY ~e41 TzleSm,,-- TOBCOM, LONDON, S.W.'. _C0~ZA~ GLEN HOUSE, STAG PLACE, LONDON, S.W.z. Ist laroh, 1966. Dr. R. Coaber, Dear Dr. Comber, Sep.reta~'s Letter ° S.B.S.G. ~s Z confira that the first meeti~ of the S.3.S.~. ~ be held at 11 a.a. on WeAnesday, 9th March, 1966 at these 0flUtes. A light luncheon will be available. The enclosed:- I. 2, foll~in~ Papers for oonsi~ration at the aeetin6 are Age (D 312). Note by Dr. J.K. Whitehead date~ l~th Jam~ary, 1~6 on the Instant CondBnsate Machine Refrigeration Unit, (D ~). Copy of a letter from Dr. P.I. I~y ~ato~ 21st 7ebruary, 1966 to Dr. A.J. LAn~sey on Cigarette Saaples for Skin P~i~, (D 310). Copy of a paper entitle~ "Oral, subcutaneous an~ intratraeheal adalniatratlon of earolnoge~Ic lactonsc an~ relate~ substanceat the intr~traoheal adainlstr&tlon of elgarette ~Lr in the ra~" by F. Diokeas et el, subaitte& to the British 3eurnal of Cancer and expected to be publlshe~ in ~une or September, ~966, (D 278). ~. Note by the Assistant Director on a aeetlng with Prof. Dickens an~ others on 2~1 ~ebz-ua~y~, 1~ st the CouPtau~A /nnti~rte Of Biochealstry, (D 29~). ~. Report reoeive~ f'roa the French Tobacco Monopo~T on research carried out durin~ 1~ entitl~A ~he Nitrogenous Heteroeyolie Co~pounda in Smoke CondensAte," (D 5~). 7. A report received froa Dr. F.J. Roe ~ted )1st JanuarT, 19{~6 on the Coapa.wieon ~or Oaroino~enioit7 on Mouse Skin of Con~enaate8 prepared ~ Air-G~re& tobacco oib~rette8 an~ Ylu~-Cur~d tobacco oisaret~es, (D ~0~). 'R1'10 8. Tou~s s£uoere~, 8.F. WA ikia~ gor Secretary, o - .- .- ~.."" - . : - : • .." C C t.. C c BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH Telepka.e: TATE GALLERY +o,4., TtJtgroBs: TOBCOM. LONDON, $.W.~. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.~. CONFIDENTIAL Dr. R. Comb er. llth February, 1966. Dear Dr. Comber, Secret&r~'s Letter - S.B.S.@. I have pleasure in enclosing a copy of the report from Dr. T.D. Day for January 1966 on Response to Con~ensates- Mice Survivin6 and Tumours Produced (D 219), Yours sincerely, S.F. Wilkins for Secretary. f I +o L.N Cr~ P~O BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO Td~koae: TATE GALLERY 2o4.1 Tclc6rams: TOBCOM, LONDON, S.W.I. CONFIDENTIAL RESEARCH COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.z. 21 st January, 1966. Dr. R. Comber. Dear Dr. Comber, Secretary's Letter S.B.S.G. 2 I have pleasure in enclosing copies of the following papers for information :- I) Note by the Research Department of B.A.T. dated 17th January, 1966 entitled "Comments on the Cigar Observation Study by Research Services Lta.", (D 123)./ 2) Extract from a letter to the Director dated 13th January, 1 966 from Dr. ~.F. Martian on his visit to Harrogate (D 121).J 3) Guidance Notes on Techniques Recommended for use in the Bio-assay of Tobacco Smoke Condensates, dated January, 1966, (D 93). f" ~) Report received from the French Tobacco Monopoly on research carried out during 1965 entitled "Health:Problems - Biological Tests", (D 58). Yours sincerely, S.F. Wilkina, for Secretary. Enos° 0 0 t.~ 0", BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL E Tdephor~: TATE GALLERY zo4t Tel=gTalu: TOBCOM, LONDON, S.W.,. GLEN HOUSE, STAG PLACE, LONDON, S.W.a. CO~I~RTIJL Dr. R. C crab er. 17th January, 1966. I / / Dear Dr. Comber, 8ecretarT's Letter - S.B.S.G. I I have pleasure in encloslng the followa~n8 papers for information:- 1. Minutes of the 12th Meeting/of the B.A.S.@. on 5th January, 1966, (D 7~) • 2. Note by Mr. Jo Wright dated 6th January, 1966 ca the Proposed Division of work between the SoB°$.@o and the a.s.~. (D ~9). / 3o Report from Dr. T.D. Day for December, 1965 on Response / to Condensates - Mice Survivi~ and Turnouts Produced, (D 71)." ~, Note by ~r= J. Wright of Carreras Research Division dated 7th Jauuary, 1966, entitled "The carcinogenicity of the known polycyclic aromatic hydrocarbon content of tobacco smoke," (D 81 ). / 5. Notes by Dr. A.J. Lin~sey dated 11th JanuazT, 1966 on a discussion ~th Dr. T.D. Day on the subject of Dr. Eaves' ~se~ch, (D 78).J 6. Note, showing nenbership of the variotm tom.trees of the Tob&oco Research Council as at Ist J6nuary, 1966, (D 56)." 7° Note by the Research Department of B-AcT° dated 12th January 1966 on the Preparation of Condensate with added ~ and ~ 30 for Hunting'don, (D 99). ~/ Yours sincerely, S.~. ~ilklns for 8ecre~r~r. Rnos. .=====b 0 0 La~ BATCo document for Legal Services • Health Canada 17 May 1999

C~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL GLEN HOUSE, Tel,grams: TOBCOM, LONDON, S.W.. LONDON, S.W.:. • "+":,+- -3 JAN1966 t 3 st Deoember, 1965. com~zDmn'z~ Dr. I.W. Hughes. Dear Dr. Hughes, .... . .... S_ecretar~ s Letter - B.A.S.&. 57 I have pleasure in enclosing further papers for consideration at the next B.A.S.@. meeting on 5th January, 1966:- /a I ~os: lo e Q ~e Note by Dr. T. D. Day dated 22nd December, 1965 on a visit to Prof. H.S~ith, (C 1659)./ Extract from a letter to the Assistant Director dated 22r~ December, 1965 from Prof. H. Smith, (C 1660):~/ Note by the Director dated 17th December, 1965 on Intra-Cellular Research Project, (C 1619).~/ Supplementary note on !ntra-Cellular Research Project dated 17th December, 1965, by the Director, (C 1618). / Yours sincerely, S. Y. Wilkins for Se cretar~. O Cr~ Cr~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tcltplm.e: TATE GALLERY 1o4' Telegr,~ms: TOBCOM, LONDON, S.W.z. CONFIDENTIAL Dr. I.W. Hughes, Dear Dr. Hu~hes, /~.u------- ' °.°,, Secretary's Letter B.A.S.G. 56 GLEN HOUSE, STAG PLACE, LONDON, S.W.I. 20th December, I~65. I have pleasure in enclosing the followinfi papers for information:- I) ~) Charts and tabulations of the results of the main Harrogate experiment prepared by Mr. D.H. Beese dated December, 1965, (c 16o~). Letter to the Director dated 1Oth December, 1965 f~om Dr. F.J.C. Roe, (C 16~3). 3) Letter to the Director dated 16th December, 1965 from Prof. R.D. Passey, (C 161~). Yours sincerely, I ., S.F. Wilkins, for Secretary. Enc s, (D w BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL / Tdcphoac: TATE GALLERY 2o4., Tdesraau: TOBCOM. LONDON, S.W.:. Dr. I " Hu~hes Research & Develo~m=.nt 1 / D E C 1965 .... o., ....... ,...,, .... , • - ,. 'o GLEN HOUSE, STAG PLACE, LONDON, S.W.t. 15th December, 1965. Dear Dr. Hughes, Secretary's LeTter - B.A.S.G. ~5 I confirm that the next meeting of the B.A.S.G. will be hel~ at 11.00.a.m. on Wednesday, January 5th, 1966 at these Offices• A light luncheon will be served. The fo2_lowing papers are enclosed:- For the meeting I) Agenda (C 1608)/ 2) Report from Dr. T.D. Day for November, 1965, on Response ~o oondenaazes-Mice Surviving and Turnouts produced (C 1~79)J 3) Addenda ~o Dr. T.D. Day's November reports, (C 1586)vt 4) Notes on Skin Painting Experiment by Carreras Research Division dated 9th December, 1965, (C 1591)J 5) Notes on the Carcinogenicity of the known polycyc!ic aromatic hy~ocarbon con~ent of tobacco smoke, by Carreras Research Division dated 8th December, 1965 (C 1598)~/ 6) Letter to ~he Secretary from the Battelle-lnstitut dated 2rid December, 1965, concerning Inhalation (C 156~)~/ Pa~er for Information 7) Note of Stock position of Cigarettes at Harrogate as at 30th November, 1965, (C 1541) Yours sincerely, S.I~. Wilkins, for Secretary. Enos. 0 CD CO BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH Te/ep.~at: TATE GALLERY 2041 T=lcSta~: TOBCOM. LONDON, S.W,I. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.[. CONFIDENTIAL Dr. I.W. Hughes. 2rid December, 1965. DearDr, Hughes, Secretary's Letter B.A.S.¢. 5A I have pleasure in enclosing the following papers for your information:- I) Note by Dr. T.D. Day dated 2@th November, 1965 on Progrese of Histology, (C 1515). 2) Note by Dr. T.D. Day dated 22nd November, 1965 on Animal Husbandry and Condensate Dosing, (C 15OO). ~~incerely, H.B. Grice, Secretary. i . F.J~C8. P ....... " to - Development -- 3 b F_ C 1965 ............... *--..o°..... ° ........... "°°°°°oee ".- .............. .°° ........ o O O BATCo document for Legal Services • Health Canada 17 May 1999

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TOBACCO Teltp~: TATE GALLERY 2o4.1 Iclrgra~: TOBCOM, LONDON, $.W.t. RESEARCH COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.l. 8~h November, 196.5. C ~YlIENTIAL Dr. I.W. Hughes, Dear Dr. Hughes, Becretar~'s Letter - B.A.S.G. ~2 I have pleasure in emclosring further papers for consiaeration at the meeting of the B.A.S.@. on 11th November, 1965, at the T.R.C. Laboratories, Harrogate:- Agenda Item le Report from Dr. T.D. Day for October, 1965 on response to condensates - mice survivi~ and tumours produced, (C I~30). Ca) 2. Letter to the Director date& 5th November, 1965 from Dr. C.M. Fletcher, (C I~27). 10 En~S. Yours sincerely, S.F. Wilklns for Secretary. Rese~rc~ & Development Rcvd~ -9 NOV196,5 A,.~ - ......................... ~'L t Lrl: ... .....*~..e....~.~. eeeo°e°°-o......oeet, File: C ¢,.,, L,,. BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tclcp&,a:: TATE GALLERY 2e41 Tdcyams : TOBCOM, LONDON, S.W.I. GO ~IDENTIAL Dr. I.W. Hughes. GLEN HOUSE, STAG PLACE, LONDON, S.W.I. 5t, h November, 3.965. /° I Dear Dr. Hughes, Secretary's Letter B.A.S.G. 51 I have pleasure in enclosing further papers for consideration at the meeting of the B.A.S.G. on 11th November, 1965, at the T.R.C. Laboratories, Harrogate :- Agenda item I) An amended report from Dr. T.D. Day for September, 1965, on response to condensates - mice surviving and turnouts produced, (C 1399). This replaces Document No. C 1345. 2) Correspondence between Mr. W.S. Paige and Dr. T.D. Day on "frequency of dosing", (C IA13). 3) Report by Dr. B.R. Davis on the Symposium on 1 Inhaled particles and Vapours at Cambridge in ! September, (C 4408). (b) @) Note by the Assistant Director on a meeting with Professor H. Smith, dated 2hi November, 1965, (C I~16). EriC3. 5) ~) 7) Note by the Assistant Director on a visit to the M.R.C.'s Pneumoconiosis Research Unit on 28th and 29th October, 1965, (C I~15). Notes on a meeting between the Director, Assistant Director and Professor R.D. Passey on 2nd November, 1965, (c I~Io). A ~ ~ f 10 Letter to the Director dated 29th October, 1965, from Dr. C.M. Fletcher, applying for a grant in aid of research, (C I~I@). Yours sincerely, S.F. Wilkins, for Seeretar~. I0 I''' ! [ 0 BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tdrgh~e: TATE GALLERY lo41 Telegram: TOBCOM, LONDON, S.W.:. GLEN HOUSE, STAG PLACE, LONDON, S.W.:. ist November, 1965. CO~!DENTXA~ Dr. I.'. Hughes. Dear 3r. Hughes, Secretary' s Letter - B.A.S.@. 50 I have pleasure in e~elosing a copy of the Agenda (C I~00), for the next =ee~ing of the B.A.S.G. on llth No~ember, 1965, at the Harrogate Research Unit. / Eric. ? Yours sincerely, S. F. Wilkins for Secretary. ,..P, ~ r>... ...... : -..- - 2 :',.OV ',755 m C C L~ (,.M BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Tdrpkaa¢: TATE GALLERY 2o41 TeltOr~raj: TOBCOM, LONDON, S.W.l. CONFIDENTIAL D~'. !.::. ?:uShes. i i i, I _ I I. a~yd.. I NOVi965 Ack. : .................................. ~n by: ............................... e~...°o°~e.°°l.op°*.°~*J°*~.°°°° File : ............................. GLEN HOUSE, STAG PLACE, LONDON, S.W.I. 2~ch October, 1965. Dear Lr. Eu~--.e~, Secretary's Letter B.A.S.G. k9 I confirm :ha~ the nex¢ meeting of the B.A.S.G. will be held at 9.30 a.m. on Thursday, 1~th November 1965, at the Harrogate Research Unit. An Agenda for the meeting will follow° The following papers are enclosed for information:- 2) 3) Interlm re~ort da~ed October 1965 on the main Harrogate ~periment, prepared by the Research Department of the Imperial Tobacc~ Company (C 1586). Charts prepared by Mr. D,H. Beese dated 15th October 1965 on the Harroga~e results (C 13~9). Le~er ¢o the As~ismant Director dated 15th October 1965 from Dr.~J,K~ Whitehead (C 1352). ~) Draft second edition of the Agricultural Chemical Testing Scheme (C 1324 revised). Yours sincerely, S.F. Nilkins, for Secretary. m~cs. O O Cr~ BATCo document for Legal Services : Health Canada 17 May 1999

J TOBACCO RESEARCH Tcltplmt~: TA'I"£ GALLERY 204, Ttlesroms : TOBCOM. LONDON, S.W. ,. COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.x. 18th October, 1965. CO~IDENTIAL Dr. 1.7¢. Hughes, Dear Dr. Hughes, Secretary's Letter - B.A.S.;. I have pleasure in enolosing the followlngpapers for your information:- le e ~e PAper by the Assistant Director dated 12th October, 1965, on the contents of the leotures delivered at The British Occupation&l~glene Society International Symposium on Inhaled Particles and Vapours, (C 1329) Note by the Assistant'Director dated 5th October, 1965 on The Zffects of Smoke Constituents and Aerosols of Condensate Fractions on the Clearance of Bacteria from the Respiratory Tract - A Possible New Bio-assay Report from Dr. T.D. Day for 8epteaber, 1965 on Response to Condensates - Mice Surviving and Tumours Produced, (C 13~5). P Yours sinoerely, 8. Y. Wilkins for Secretary. Encs, m C C p C~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Td~Fhar~: TATE GALLERY 2o41 TdcSrar.:: TOBCOM, LONDON, S.W.z. Resoa.r'.,;h +I,_ ~.._~. ..... :,at Re+++" ! 40~ +~5 Aek. • ..... Bee- ,'3" •. ....................... File: ......................... -j GLEN HOUSE, STAG PLACE, LONDON, S.W.l. 13th October, .1965. Dear Dr. Hughes, 8eoretarT's Letter - ~.~8.@. AT I bare pleasure in encloslng the followlug p&pers for your ix~ora&tton=- 1. Note by Dr. B.R. Davle aate~ 5th 0otober, 1965 on the straia~ of mioe to be used for inflation ex~rlaental worm on the Harris aloha, (C 1321). 2. Note by Dr. T.D. Day Rated 5tJ~ Ootober, 1965, on progress of Hietologioal worm in relation to the erperiaent, (C 1316). ~o Revisel note by the B-A.T. 0oapany dated 8tb 8epteaberp 1965 on saaples for Ciliaetaais Teatlng, (C 1178). Yours sinoerely, 8. Y. Wilkina for Seoretary. Ib, cul. CD CD Cr~ ~Jn C~ BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telepl~ne: TATE GALLERY le~,z Tele,gr,,m, : TOBCOM, LONDON. S.W.I. CO~FID~ZA L Dr. I. W. Eu~hes. Dear Dr. Hughe s, i i -Research & Development. R~_.:. | 7 5 E P 1965 A~ ..................... *.- S.'."" ~t: ................... .e°.o.. °..., I~! e'eee* qle- . .......................... Secretary's Letter B.A.S.G. ~6 GLEN HOUSE,. STAG PLACE, LONDON, S.W.,. 16th September, 1965. I have pleasure in enclosing the following papers for your information:- / ! I) 2) 3) Minutes of the IOth Meeting of the B.A.S.G. on Thursday, ~h September, 1965, (C 1191). Revised note by the Secretary dated lOth September, 1965 on =he Second Series of Tests on Maleic Hydra,ide, (C I121 revised). Note by the Secretary dated~J=September, 1965 on Use of Temporary Buildings at Harrogate, (C 1159). @) Note by the Director on a discussion with Dr. P.R. Peacock, on 25th August, 1965, (C i~9). 5) Note by the Director on a discussi6n with • Dr. P.M. Peacock, on 25th August, 1965, (C 1150). Yours sincereAy, S.F. Wilkins, for Secretary. ~n0st C C 0" BATCo document for Legal Services • Health Canada 17 May 1999

TOBACCO TdcpMnc: TATE GALLERY zo,,~ Telrsraz~: TOBCOM, LONDON, S.W.=. RESEARCH COUNCIL GLEN HOUSE, STAG PLACE, LONDON, S.W.t. 6th September, 1965. CONFIDENTIAL Dr. I.,%'. Hughes, Dear Mr. Hughes, Secretary's Letter B.A.S.G. AA I have pleasure in enclosing a copy of a paper by the Director and Assistant Director dated 6th September, 1965 on Research using Non-Human Primates which will be considered at the next meeting of the B~A.S.~o on Thursday, 9th September, 1965 (C 1105). Yours sincerely, / t EI~C a Research & "l)evel0pment -7 S£P1965 ~,~. o ...o... ~ °. °.. **~el4kJo I i i~.1,, • • - ........ o~ Q • *o ~ oo61 • .Q*Ioo IQ.o* iweol Filj.L .......................... |1 S.F. Wilkins, for Secretary. 0 Q~4 Cr~ CO BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL Telephone: TolcGalIeFg. 204! Telegrams." Tobcom. London. S VJ. h CONFI D~TIAL Dr. I.W. Hughes ,~esearch & Developm,,-.-,,' e~----U -3 $ E P 1%5 f,c~ : . ...... "- ----., ,o ,,.,.,.. ~." ......o° ......... o....,..°o° Glen House. Stag Place. London. S.W !. 2n~ September,1965. Dear Dr. Hughes, Secretary' s Letter B.A.S.G.~5. I have pleasure in enclosing the follcwing papers for the next meeting of the B.A.S.G. on Thursday, 9th September, 1965:- i) Note by the Director dated 2nd September, 1965 on Biological Experiments Using Cigar and Air-cured Tobacco, (C ll20). 2) Note by the Director dated 31st August, 1965 on Prof. Peacock's suggestion for inhalation research, (C lng). 3) Note by the Secretary dated 2nd September, 1965 on the second series of tests on maleic hydrazide, (C ll21). ~) Abstract of a paper to be read by Prof. R.D. Passey at the meeting of the British Association of Cancer Research to be held in Dublin on 22nd - 25th September, 1965 entitled "The Biological Effects of Cigar and Cigarette Smoke", (C lll6). 5) Note by the Secretary dated 31st August, 1965 on Duty-Free Tobaccos for Health Research , (C Ill2). Yours sincerely, S. F. Wilkins, for Secretary. ~C8. C C C~ Q.r- ~C BATCo document for Legal Services : Health Canada 17 May 1999

TOBACCO RESEARCH COUNCIL T¢lc, pbone: Tal'cGol|c~l. 204.1 T¢lccjrams : Tobcom.London.S.W I. Gten House, Stacj Place. Londoa. 5.W.I. C C?~ !DECRIAL Dr. I. W. Hughes. 26th August,1965. O~r.r Dr Hughes, S¢c__.r~t-.r_.__/C'~ L__£ct~cr B.A.~.G. ~2 ! corfirm th~.t thc next m-ctina cf th~ B. ~..~.G. ;,'ill bc h~id ut ~ " ~.h2 on Thurs&':y, 9th Scptczb~r 1969 ct th~sc offices. k li=ht lt-nch ;:ill bc scrv~d. i~na follo':in,7 p'pcrs "~ ~ncloac! for the z~eting:- I) ;~n~ ( c 1o99 ). 2) ~ot~ by the Assist-nt Dir:ctcr i:.tcd 16th Augus¢ 196.-', on the R~l~v'nc~ of :unimnl T~sz= to Hum:.n Smokinj "~d Lung C~mccr ( C lOi~ rcviz&d ). 3) Not: bS- !:~. D.H. B~ose i-t:~ 17th .iu~'ust 1965, on the Ci{-r Obscrv-tion Study ( C 1076 ), i) Copy of" ". lutz~r from th& 3~cr ~t-ry d-~tcd 26th August 1965, tc tha BaCzcli~ -nstitu:c on the Iriq'.ittion Experiments, ( C 110b. ). F~cs. Yours sinc~:'clE, ~. F. ~i!~ui~n s, for S c cr ~t.'/'y. . . oe ~t .el • ,.°° °.. e0~o~*°~ • ,-* C~

TOBACCO RESEARCH COUNCIL Telepbone.- Totc GaIle~j 2041 T¢legro.ms, Tobcom. London. S.3AT. I. Glen House. Stag ~ace, London. S.W. 1. C ONFIDE?~ Dr. I.:7. Hughes. 11th August, 1965 Dr. Hu£hes, I h~-w plcasurc in &ncloaing the following ps.pc;rs for your inf~mction: - I • me Note by Dr. T.D. Dzy on ". "¢isit :o Prof. F. Diek~ns ~-ncl Dr. H.E.H. Jones, 28th July, 1965, (C 993). Notc by Dr. ~K. Armit~gc on visit t6th~ Huntingdon Research Centre - 27th July, 1965 (C 988). o L~tter to th~ Sccr~t~ry 6~tcd 2Cth July, 1965 from Dr. H. Eder of thc Bnttcllo-InstiCu~. (C 1009). Note by 1~iss J. Tho.,,:r.s, d~tcd 3ri August, 1965 on Experiments to zscertain the dcgrcc of inbreeding of I.C.I. s~r~in mice ~nS skin @r~ting (C 1010). e L~tt~r to the Dirc=tor dated 3rd Au_~u~t, 1965 from or. (c 1o3o). 6o L~ttor to the Secrctr.ry dated 6th August, 1965 from K.H. Harper of the Huntir.g6on Rese~-reh C:-ntro on the 2na Seri~s of Malcic Hydrrozide Tests, (C 1029). 7o i | - I llesear¢ & I)e, slol~me~l Rcvd:___ 12 AU6 5 t,@-__.. ....................... Noto by tha Sccr_t-~y d~.t~d 30th July~ 1965 on th¢ H~-rogat~ Ruillin$ Fro zr~zzc, (C IIO0). Yours sincerely, S.F. Wilkins for S~cretary. o°..°.° °.....°~.." ,,., i E~es. CD O cr~

TOBACCO RESEARCH COUNCIL CONFIDENTIAL Telephone: Tats Gallce9 2041 TelegEums : Tobcom. London. S.9~. 1. . . ,-~-. [-~ Re~e~h a Development Re,,, 2 ; JUL 19~ Ack • .................... S~e~.___t,.': ................... Dr. I.W. Hughes Dear Dr. Hughes, • .,....lo......oo 1 Glen House. Stag Place. London. 5.W.I. 28th July, 1965 Secretary's Letter B.A.S.G. ~9 ! have pleasure in enclosing the following papers for your information : - I) Paper by Dr. T.D. Day on the International Conference on Lung Tumours in Animals - Perugia, 24th - 29th June 1965 (c 95~). 2) 3) ~) Note by Dr. T.D. Day on the Future of Inhalation Studies at Harrogate (C 957). Report on Visit by Dr. B.R. Davis to the Battelle Institute Frankfurt (C 961). Report by Dr. T.D. Day for June 1965 on the Response to Condensa~es - i~ice Surviving and Tumours Produced (C 928). 5) Copy of an article entitled "Some Unsolved Problems in Lung Cancer Etiology" by Dr. F.J.C. Roe and Margaret A. V~alte#s which appeared in Prog. exp. Tumor Res. vol. 6 (c 975). Yours sincerely, S.F. Wilkins for Secretary. Encs. 0 0 t.,4 L,,J 0", 0",, t.l,J

TOBACCO RESEARCH COUNCIL Telephone : T~te GulleP~j 2041 Telegrmas : Tobcom. London. S.W. 1. Glen House. Stag Place, London. S.W', 1. C 0h~ ~ :..'~TT ~L Dr. I.W. Hughes. 26th July 1965. Dear Dr. Hughes, Secretary's Letter - B.A.S.G. )8, I have pleasure ~n enclosing for your ir2ormation a translation of a Report, dated May 1965, on the Rosoarch carried out by the German Cigarette Industry, 1959 - 65, (C 925). Yours sincerely, S.F. V~ilkins For Secrstary. ".osesreh & Development 2 7 JUL 1965 ,~ck : ............................. See.,:. by: ........................... ==.°.,,=.eoo ,....°~. ,°. ...... File: ................................... -- ml _ 0 0

TOBACCO RESEARCH COUNCIL Telephoae : Tat• Galtev~l 204t Telegrams = Tobcom.Londou. S.W:. t. Olem Hour~. Stag Pqacc. Loadoa, S,W. 1. 21st July, 1965 CONFID~VI~AAL Dr. I.:~'. Hughes• Dear Dr. Hu~hes, Secreta~j's Letter - BASt ~7 I have pleasure in enclosing the following papers for your information:- (I) Minutes of the 9th Meeting o~ the B.A.S.G. held on 8th July, 1965 (C 931). (2) Note by the Director dated 3rd June, 1965, on Skin Fainting Experiments, (C 770), (3) Key to Code of T.R.C. Cigarettes-June 1965, (C 912). (A) Charts 0f percentages of Tumour Bearing Animals (C 932). ~cs • Yours sincerely, S.F. Wilkins. Pro" Secrctary. ~esearch & Development w 22 JULl%5 -,. .e e ea ;,~ .................. ~. I.-+,°°- ~ wl • ee, e.eeeI..we~eeBue**°a° I~o, ......... ~., °....°.°o.--' D C C

TOBACCO RESEARCH COUNCIL T<lrpko,¢: TATE GALLERY 2e4= Tclcsr=rm: TOBCOM, LONDON, S.W.l. GLEN HOUSE, STAG PLACE, LONDON, S.W.l. 6th July, 1965. CONFIDENTIAL Dr. I.W. Hughes. # Dear Dr. Hughes, Secretary's Letter - B.A.S.@. ~6 I confirm that the follow~g papers were sent to you yesterday under the above Secretary's Letter Number, and are far use a~ the forthcoming meeting:- (1) Note b~ Dr. Da~ on the Perugia Conference, (C 882). (2) Note by Drs. Tughan and Lindaey c~ inhalation work by Battelle, (C 875). (3) N@te by the Director on the instant oondenaate machine of B.A.T. Hamburg, (C 7~). (4) Letter from Mrs. Flake, (C 870)° Yours sincerely, 8. Y. Wilkina, for Secretary. Research & De Yel0;me.t ecve---L - 7 JUl, 1965 AC~ ," .,e .. ,.°..,~..°.,**.,., ~.., "'*''''' *etlee...o° a=*°'°-°e-e°ll...4,.•-o ~•'°*''* ...... °**,...e.•° .... (...- C..=

TOBACCO RESEARCH COUNCIL Tdepbone : Tote G~c~j 2041 Tctcgrams: Tobcom, Lo,do,.S.W.I. Glen House. Stag Pla~. Londou. $.W.t. 29th June, 1965o CONFIDENTIAL 3 Dr. I.W. Hugh, s. Dear Dr. Hughes, Secretary's Letter - B.A.S.G. ~ Next Meeting i confirm that the nex~ meeting of the B.A.S.G. will be at 10.30 a.m. on Thursday 8th July at these Offices. The provisional Agenda (C855) is enclosed, together with the following papers: - I. Notes on the special B.A.S.G. meeting in Harrogate on 31st May (C800). 2. Progress repcrt by Dr. RoJ.C. Harris (C783). 3. Correspondence with Battelle about examination of experimental animals (C817 and C85@). t A, Dr. Day's report for May (C801). 5. Charts by Dr. Day on tu~our ~-ie!ds at Harrogate (C808). Y°~~icerelY J H.B. GRICE Secretary. I Research & Development 30JUNP AcL ........................ ~.~, .~ ~v: ..................... ~°..oo°°o,°°°...oeo, • Fi!e: ........................... c~ (.a~J O'~

TOBACCO RESEARCH Tdelpbome: To.~ Golte~j 2041 Telegeoms ~ Tobeom. Londo=.S.W.1. COUNCIL Glen House. Slag Place. LoDdon, S.W. 1. 27th May, 1965. CONFIDENTIAL Dr. I. W. Hughes. DearDr- Hughes, Secretarv'z Letter - B.A.S.G. 5& ., b I have pleasure in enclosing the following papers for your information:- (l) (2) (5) Notes by the Director dated 21st May, 1965 on the completion of Phase ii of the expansion of Harrogate, (C 709). Letter to the Secretary dated 26th May, 1965 from Mr. K. H. Harper, Huntingdcn Research Centre, on the cc~ts of testing Ma!eic Hydrazide, (C 7Q~l). Aide-~lamoire on Inhalation Research dated 18th May, 1965, (C69!). Note by Dr. T.D. Day dated 20th May, 1965 om the Technical Staffing of the Histology Laboratory, (c 713). Enos: Yours sincerely, S. F. Wilkins for Secretary. " '& I Research, Develoome.t, ~:v~__~ 2 3 HAY 1965 :, Ack : ............................ ~--.~ ~..- . .................... I F;le: ................... 0 0 (..,,1 C~ 0", O0

TOBACCO RESEARCH COUNCIL Telephone : Talc GeLIitr~ 2041 T¢legvoJms : Tobcom, Londou, S.W.t. CONFIDENTIAL Dr. I. ;7. Hu~hes Dear Er. !'u~-hes, ~.~,:earch & Oeve!oome,t: 2 i MAY i965 ., .,, ......... °°°°, .... ,.~°,,o, .... °.o.,,°°~ L ~.~ ~.. ........... ..o .... , ...... ,o, Secreta~T' s Letter - B.A.S.G. Glen House. Stag Place, London. 5.W.t. 20th May, 1965. 33 I have pleasure in enclosing the following papers for your information:- (i) Minutes of the 8th Meeting of B.A.S.G. on 5th May, 1965, (c 676) (2) Letter to the Director dated 28th April, 1965 from Professor F. Dickens on Maleic Hydrazide, (C 625). (3) Note by Dr. B. R. Davis dated 12th ~ay, 1965 on the Utilisation of Animal House No.2, (C 67A). (4) Note by the Assistant Director on a discussion with Dr. E.L. Wynder on the l~th May, 1965, (C 689). (5) Letter to the Director dated Ath May, 1965 from the Secretary of the American Medical Association, (C 685). (6) Report by Dr. T. D. Day forApril, 1965 on Response to Condensates - Mice Surviving and Tumours Produced, ( C '671). (7) Amended Page to Document (C 506) - Dr. Day's Report for March, (C 658). (8) Article by F. G. Bock, et al, entitled "Carcinogenic Activity of Cigarette Smoke C~ndensate. lll. Biological Activity of Refined Tar from Several Types of Cigarettes", in the Journal of the National Cancer Institute - April, 1965, (C 652), (9) Note prepared by the Carreras Research Division on the Analyses of Harrogate Smoke Condensates from T.~. Cigarettes, (C 65A). Yours sincerely, $. F. Wilkins. for Secretary. C C C~ ~C

TOBACCO RESEARCH COUNCIL Telephone : T~Gollet.g 2041 Telegrams, Tobeom. London, S.W~. I. Glen House, Stag Place. Londou, S.W. 1. 30th April, 1965 C 0N-F I DENT IAL Dr. I.',". Hughes. Dear Dr. Hughes, Secretary's Letter B.A.S.G. ~2 I have pleasure in enclosing a copy of the Report of the ~epartmen~al Committee on Experiments on Animals, ~fnich ~:ill be discussed at the next meeting of ~he S~udy Group on ~ednesday, 5th May 1965. Yours faithfully, S.F. Wi!kins fo:" Secretar~ ! Encs. q ....... °'° .... "°""" t ooo...o-.' i0-. ..... i • .,. ....... .,--oo - . ...... . .... | 7 0

TOBACCO RESEARCH COUNCIL Telcpbonc; Tate Gcdlceg 204.1 Teleg,,mns, Tobcom. London. S.W. CORF IDE~rIAL Dr. I. i;'. Hughe -. Dear Zr. Hu hes, I, Research & Develooment Rcvd---'-L 30 APRI965 l'-c~. "= ............................ C,~* . r ~ .............. ,,.,,,o ,.,,,, ..... ,,,,,.,,,, F.:,'e : ........................... I i J Glen House. Stag Place. London. S.W.I. 29th April, 1965. ,Secretary's Letter B.A.S.G. ~I I confirm that the next meeting of the B.A.S.G. will be held at 11.00 a.m. on Wednesday 5th May 1965 at these offices. A light lunch will be served. The following papers are enclosed:- For the meeting:- I) Agenda (C 621). 2) No:e by Dr. T.D. Day dated 26th April 1965 on the Classifica- tion of Mouse Skin Tumours (C 601). 3) Note dated 29th March 1965 to the E.C. for Biological f Letter to Mr. D.A. Coulson Secretary of the T.A.C. on 5) on the Recommendations from T.S.C. Tests on MH and MH-30 (C &6~). dated 5th April 1965 from the Maleic Hydrazide (C 56&). Letter to the Secretary of the T.A.C. dated 16th April 1965 from Mr. D.A. Coulscn on Maleic Hydrazide (C 578). 6) 7) Note by Dr. T.D. Day dated 27th April 1965 on Inhalation Research (C 588). Note on a microscope for Dr. B.R. Davis (C 599). 8) Notes by the Assistant Director on a meeting between Prof. L.M. Lamerton and Dr. F.3.C. Roe, and the Director, Assistant Director and Dr. T.D. Day on qAth April 1965 (c 592). Cont'd .... I O O t.,4 Cr~ "-4

-2 - 97 ~:-~e "~-- "~-- ~.ssistant Dire~-tor dated 2qth April 1965 on ~j .... C.~r.~r..~ ~ for S.E.I.T.A. (C 619) Ez-r~_ct fr=m J~/&A, April 12th 1965, "Reduction of T" z~ri~:-ni:ity of Cigarette Smoke" by Dr. E.L. V~.der and Dr. D -off mann (C 620). For !z~"orzation:- I) Note on Lung Cancer in Experimental Animals (C ~g&). 2) Extract from the Imperial Cancer Research Fund Annual Report sz:d Accounts 196& (C 559). Ncte by Dr. ".D. Day dated 12th April 1965 on the visits cf the Dutch and ~h'ench parties to Harrog~t~ (C 570). ~.CS • Yours faithfully, S.F. Wilkins for Secretary. O CXD L,J u L,J Cr~ rxo

TOBACCO RESEARCH COUNCIL Telepbo.c : Tot~ Galle~j 20&I Telcg~.ams : Tobcom. London ;S~ .... _ ..... ; ..... 1 " ....... ,--m.~-..~- 6 J . . ° J ~ ,, , ! ~....~.- .., ............. CONFIDENTL~. • 9Qoo.o. ................... • ,-..mmw ~r. i. "". Hushe~. Glen House. Stag Place. London. S.W.I. 15th April, 1965. Dear 5r...u~he., Secretary' s Letter B.A.S.G. 30 I have pleasure in enclosing the following papers for your information:- le Testing of .Smoke Fractions: (a) Paper prepared by Dr. J.K. Whitehead dated Ist April, ~965 (c ~5). o (b) Letter to the Secretary dated 8th April, 1965 from Dr. J.K. Whitehead amend/ng the above paper (C 529). Note prepared by Dr. J.K. Whitehea~ dated 7th April, 1965 on Bulk Smoking of Small Ci6ars (C 518). Yours sincerely, S.F. WlLKINS for Secretar~r. ~ItOS° CZ~ .m=~V cr~ -~j

TOBACCO RESEARCH COUNCIL Trlzpboae : Talc Galle~j 2041 Telegrams ~ Tobcom. London. S.~r. 1. Glen House. Stag Place. London. S.W. h CONFIDENTIAL Dr. I.W. Hughes. 12th April, 1965. Dear Dr. Hu@es, Secretary' s Letter B.A.$.G. 2~ I have pleasure in enclosing the following papers for your information: i. Report by Dr. T.D. Day on Response to Condensates, Nice Surviving and Turnouts Produced for March 1965 (C 506). 2. Letter to the Director dated 26th March 1965 from Dr. E.L. Wrnder (C 502). 3. Amendments to Page 23 of Document B 1255, T.R.C. Review of Research Activities for 1963/6~ (C AlO). • Yours sincerely, $.F. WILKIN$ for Secretary. 1~Ttc s.

TOBACCO RE:SI=ARCH COUNCIL Tdq~one, Tm Galle~j 2041 T¢izgrams.. Tobeom. London. S.W.I. Olca Hour. Stacj l~.ace. Londoa. S.W. 1. c~rri D~;TI~ 5th April, 1965. Dr, I.W. Hughes. Dear Dr. Hughes, Secretary's Letter B.A.S.G. 28 I have pleasure in enclosing for your information the Minutes of the meeting of the B.A.S.G. held on Wednesday, lOth March 1965 (C Z~28). Yours sincerely, t .dc:. S.F. WILKINS for Secre tar~r. E~Ic. -6AP mS I AGk, +: ................................ " ~',--~..~-~+-: ......................... i I °o.°°°,- ..... . .. °°...,.,,Bt.| FII~ : ................ O CD u *,,.,,,j (,.J=l

TOBACCO RESEARCH COUNCIL Telepboae : Tate Galles..g 2041 T¢l,,'gs,mns = Tobeom. London. S.MK. 1. Glen House, S~ag Place. Lomdon, S.W. 1. CONFIDENTIAL Dr. I.W. Hughes. 5th March, 1965. Dear Dr. Hughes, Secretaqf's Letter B.A.S.G. 27 I have plezsure in enclosing the Agend~ (C~L6) for the next meeting of the B.A.S.G. at lO.O0 a.m. on Wednesday, lOth ~arch 1965 at the TRC Laboratories, Harrogate. The follo:',ing papers are also enclosed: 1. Report by Dr. T. D. Day on Response to Condenszte~, !~ice Surviving and Tumours Produced for February 1965 (C 3&O). So Letter to the Secreta<~ dated 22nd Febmaary 1965 from Dr. J.K. [-."hitehead giving an up-to-date smoking programme (C 280). 3. Note by the Secreta.--f dated 15th Februar-J 1965 cn a discussion uith Dr. Schwick of the Battelle Institute (C 2&5). &. Letter to the Director iated 23rd Febraa~- 1965 from Prof. W.V. /;:a3mecrd (C 296). o Un.cub!ishei p?.per by !~rs. A. Flax on "The Effect cf 9:10- dizetl~yl l:2-benzanthracene on Young }~'ice of Low ~nd High Cancer Strain" (C 321). 6. Paper _wrepared by Mr. ;.W. "~:oore entitled "Analysis of Smoke Condensate ,fror:l T.&. Filter Cigarettes" (C 3L~l). Encs. Yours sincerely, ........... ~ D..':!--" -~ ~-, -- .°,,g. = =..- - -; MAR i965 i /'"L ........................... ', .................... i ri!e • ....................... i S.F. ~.~I/CINS for Secretary/. C) (~ L.,4 .,....m Cr~

i °- TOBACCO RESEARCH COUNCIL Te..lepbonc : Tare Galleeg 204.1 T¢leg~s = Tobeom. London. S.W~. I. Glen House. Sl'ag Place. London. S.W. 1. 26th February, 1965. C ONF IDF~NT IAL Dr. I. :';. Hughes. Dear Dr. HuEhes, Se_'~.et~_rT, 's Letter B.A.S.G. 26 I have pleasure in enclosing a copy of an unpublished paper by Prof. F. Dickens and Dr. H.E.H. Jones entitled "Further Studies on the Cemcinogenic Action cf Certain L=czones and Related Substances in the Rat -_n.d Mouse" (C 195). We received this from Dr. £%itehead who worked with Prof. Dickens before he joined T.R.C. Your attention is drawn to the p.-mc.graph commencing in the middle of page 7 "A carcino~enLc property ....................... Under the conditions cf our experiment the free su'ost.-mce, maleic hydrazide, injected in an oil medi'~.m twice-weekly into r.~.ts, definitely behaves as a carcinogen (Tables i and If). " The Secretary has ".eked me to say that the mctter will be discussed at a meeting cf the Executive Committee on &th M~ch. Yours sincerely, S, F. Wilkins for Secretary. Enc. Research & Devel0.nment nl, i. 1 HARI%5 t.~l. .... ......., ..... o., "'°'°.°°-o-o.°o•°o~° z 0 (../,j CP~

°. TOBACCO RESEARCH COUNCIL Telephone: Tote Galle~j 2041 Telcgem~ns = Tobcom. London. S.W.I. Glen House, Stag Place. London, S.W. 1. CONFIDENTIAL Dr. I.W. Hughes. 17th February, 1965. Dear Dr. Hughes, Secretary's Letter B.A.S.G. 25 I have pleasure in enclosing the following papers for your information:- l* e a e Letter and its ap.oen~ices to Dr. F. Wecker of the Battelle institute dated 22nd January, 1965, from the Secretary (C 151). Translation of material issued by Dr. K.H. Weber at a Press Conference in Hamburg on llth January 1965 (C 202). Letter to the Director dated 1st February 1965 from Dr. T.D. Day (C 18~). Report by Dr. T.D. Day on Response to Condensates, Mice ~j.~~ Surviving and Tumours Produced for January 1965 (C 165). Observations on visit by Dr. B.R. Davis to the Laboratory iq.l.G~. of ProfeSsors C. & R. Leuchtenberger (C 233). Yours sincerely, Enc S • S.F. WILKINS for Secretary. 1 FEBI965 ,~,ck_...~ ........................ S~.I ~: : J=,41 J4 ~;~. -.a co

.o TOBACCO RESEARCH COUNCIL Tzlzl=bOa¢= TatcGa/les.9 204-1 Telzgm.' Tobcom. Loodon. S.~r.l. Gh~ Nous¢, Slug Place, Loudoa. S.W.t. C ONgl DENT I;~ Dr. l.W. Hughes 5th February 1965. Dear Dr. Hughes, Secretary's Letter B.A.S.G. 24 I have pleasure in ~nclosing the following papers for your information:- ~CS. 1. Letter and its enclosure to the Secretary dated 22nd January 1965 from Dr. T.D. Day (C 131). 2. Note by Dr. B.R. Davis dated 26th January 1965 on the "Investigations to b~ carried out in Temporary Hut No. 2" .i (c 3. Report by Mrs. P.A. Hutchinson dated 26th January 1965 on progress made in the Short Term Test for Carcinogenic Activity (C 155). i i , Re.~earch & O.,'veroom~,t- .... FEB ;%5 ...... * .... "°°'''°''''..,,oo "'''oo°°o.,.°o° ..... , i .....~'" ................ °°°"°°-°-° Yours sincerely, S.F. WILKINS fo_~r Secretar-j. 0 0

o. TOBACCO RESEARCH COUNCIL Teic,1>bone : Tare Galk, s-g 204t TelegFams : Tobeom. London. S.W.I. Glen House. Stag Place, London. S.W.I. CONFIDENTIAL Dr. I.W. Hughes. Dear Dr. Hughes, 21st January, 1965. Secretary's Letter B.A.S.G. 23 I have pleasure in enclosing the following papers for your information: I. Minutes of the 6th meeting of the B.A.S.G. on Thursday, 7th January 1965 (C 75). 2. Letter to the Director dated 12th January 1965 from Dr. W.W. Bates Jnr. of Liggett & Myers Tobacco Co. (C 85). 3. Letter to the Secretary dated 8th January 1965 from Dr. T.D. Day (C 55). ./ A. Letter to the Secretary dated 12th December 196& and its enclosures from Prof. A.N. Worden of the Huntingdon Research Centre (B 1253). 5. Paper showing Membership of the Committees of T.R.C. as at ist January 1965 (B 127@). Yours sincerely, S.F. Wilkins for Secretary. Encs. i_ "e'eI0 'e"i Research & 22 JAN 1965 __ File.. ..................... ~CD CO O

J I TOBACCO RESEARCH COUNCIL Telephone : Tare Gallevg 2041 Tdegra~s : Tobcom. London. S.W. 1. Glen House. Stag Place. London. S.W. 1. C0~IDEhTLIL ist J,~nu~-ry 1965. Dr. I.W. Hughes. Dear Dr. Hughes, Secr~tazT's Letter B.A.S.G. 22 i have pie:sure in enclosing the Agenda (C 9) for :h'- meeting of the Bio-assay STudy Group -_t II.3C a.z. on Thursday, 7th Jnnu:.rv 1965 at these • ;W~._, .& offices L lieht luncheon .... be provided. ~so e~lc!o s£.d "~ ~ "" ~o. your info~aticn are the following:- 1 A Trznsi"-tien froz the French of Document B ll&a - letter to the Chairman d-ted 9~h November 19(9+ -aft its enclosures from s.z.i._-.,,. (~ :!~7). 2. Letter to ~he Director d~ted l&th December 196& from Dr. F.J.C, Roe and its enclosures (B 1279). Letter to Dr ~ V;ecker of the Battelle Inz~itute dated 22nd December 1964 from :~r. J.G. Burgan (B 1276). ~. NotG prepared by 3-. J.K. ;~itohe.~-d on the Smoking Programme for the Experiz.enzs ~- .U'ro~-ess - 3Cth December _9-~i (C 1). • . ~:.~ Battell~ Institute on the 5 Letter frpm Dr F. ~ocker of ~"- Instant Condensaze Machine (C 2). Enos, | I J Yours sincerely, S.F. Wilkins for Secretary i .~°. ....... 0 CD L,4 cr~ Co J

TOBACCO RESEARCH Telephone: Tree Galle~j 2041 T¢lzgmm~, Tob©om. London. S.W. 1. COUNCIL Glen House. STag Place. London. S.W. 1. CO~ID~TL~L Dr. I.W. l~ghes. 21st December, !96~. Dear Dr. Hughes, Secretary's Lc~ter B.A.S.G. 21 The Director has 2sk=d m~ zo say thzt TRC hz~ to consider in the near future: (n) RequcsZ by R.C.P. Co~zittec for an up-to-date su.~mary of ±..C E~s~rch programme. (h) Request by French Tobacco Monopoly, unicr Exchange of Lct~crs, for ~ ~- up--o-~_.= surzary of TRC research prc~nczo, and for 2 mooting wioh the French to consilcr the possibility of co-ordin~=ing resenrch prcgr~_-c~es. (c) W~othcr c su_~mary of TRC research programme should be sent to other organiszticns with whom TRC h~s exchanged letters. It is therefore necessary to consider whether these requests should be mot ana, if so, ~h~.~ shoul~ bc szil in the summaries. As z source dccumen~ - i.e. 2 ~ocument from which nztcrizi could be drz'~.m 2~ thought fit - for use in consideration of these a~esti, ns, a review of TRC research Activities in !963-6& with 2 list of nli TRC rosearch projects nnd cxperLments (B 1255) is onc!osc~. Yours sincerely, S.F. Wilkins for Secretary mnc. _ _ _ ,, P, esearch'"& D=velo0ment - 2 5 .CTSL I ! O C C3C P~

TOBACCO RESEARCH Telephone : Ta~ GeJ~=~j 204.l Telegs-ams: Tobeom. Loudon,S.W'.l. COUNCIL Glen House. Stag Race. London. 5.W.t. CONFIDENTIAL Dr. l.W. Hu~hes. 18th December, 196J+. Dear Dr. Hughes, Secretary's Letter B,A.S,G. 20 I have p~easure in enclosing the fol!cwing papers for your information:- I. Minutes of the 5th Meeting of the Bio-assay Study ~roup on Thursday, lOth December 1964 (B 12~I). 2. A ~aper showing Membership of the Committee of the Tobacco Research Council as at ist December 19~+ (B 1231). Yours sincerely, S.F. WI'~(INS for Se cretary p,! ,search & ,Devet~:."rr~t " 2 3 .C g;4 : . !. I

TOBACCO RESEARCH Telephone : Tare Gcdle~j 2041 Telegr~rJ, Tobeom, London. S.W. 1. COUNCIL Gten House. Stag Place. London. S.W. 1. CONFIDENTIAL 7th December, 196~. Dr. l.W. Hughes. Dear Dr. Hughes, Secretary's Letter B.A.S.G. 19 I have pleasure in enclosing further papers for the meeting on Thursday, lOth December 1964, as under:- le Note by Dr. R.M. Macrae on 'Proposed Research by Mrs. A. Flake' (B 1223). e Note by Dr. J.K. Whitehead on the "Smoking Programme of the Smoke Production Sectiod'(B 1216). e ~8 Report by Dr. A.K. Armitage on "The Progress of the Goldhamer Technique" (B 1219). Paper by Dr. J.K. Whitehead on "The Biological Testing of Fractions from whole Smoke Condensate by mouse skin painting at Harrogate" (B 1218). Yours sincerely, S.F. Wilkin s for Seoretar~ ~cs. i ' ~zt" cC'~ ( , i_.. t $ ...... ......... TTTII Ti ! J 0

t TOBACCO RESEARCH COUNCIL Tctepbo,-.c: T~ Golle,.9 204I Tcte9~, Tobcom. I..~dou. S.W.t. Glen I-louse, Stag Place. Londo,,. S.W. 1. CONFiDENTJ_AL Dr. l.W. Hughes. 3rd December, 196~. Dear Dr. Hughes, Secretar~"s Letter B.A.S.G. 18 I have pleasure in enclosing a memorandum, entitled "Recommendations on the Main Experiments", by the Director for consideration by the Bio-assay Study Group, under item 5 of the agenda. (B !207), H.,. ~ GRICE Secretary. Enc. | ' t Research & [~e,,,,l,~.,.,..,t ! J s ...... -: ,- ~';4 0 J L.,,,J CO Q.F1

TOBACCO RESEARCH COUNCIL Tdel,bon¢= Tai'z Galltr9 204.1 Telzg,,axas = Tobcom. Londoa.S."N'. 1. Gl,mm Houl¢. Stag Place. Londo,',. S.W.I. C 0NF IDENT IAL Dr. I.w. Hughes 2nd December 196~ Dear Dr. ~ghee, ! SecretarY'S Letter - BASG 17 ! have pleasuru in enclosing the Agenda (B 120~) for the meeting of the Bio-assay Study GrouF to be held at 11.30 a.m. on Thursday, 10th December 196~ at Glen House, Stag Place, London. S.W.I. Also enclosed are the following papers fcr your information:- I) Minutes of the ~th Meeting held on 16th November 196~ (B 1203) 2) Paper on the Experimental Study of Carcinogenesis in the Lungs cf Animals, byDr. T.D. Day, dated 25th November 196k (B 1189). 3) Three charts on the Main ~arrogzte Experiment (B 1200). Copy of • letter to the Secretary from Dr. T.D. Day, dated 3Oth November 196k. (B 1202). 5) Explanatiod of T.R.C. Research Programme by the Director (B 11~6). .......... ": ..... ',-1.:" t ........... ~~ ~ - • "--'-mmm.mm ":'- 3 -,... t -:'~. {---_ • Yours sincerely, H.B. Grice Secretary. O cr~

TOBACCORESEARCH COUNCIL Telephone: Tale Galle~i 2041 Teleg~ms: Tobcom. london, S.W: 1. Glen Hous-, Slag Place. Loado,,. S.W. 1. 26th November, 196;+. c ONFIDEr~IAL Dr. I. W. ~ughes. Dear Dr. Hughes, Secretary's Letter B.A.S.G. 16 i confirm that it has now been agreed that the next meeting of the B!o-assay Study Group will be held in the London Offices of T.R.C. at 11.30 a.m. on Thursday, IOth December 196&. A light lunch will bc served. I enclose the following papers for your information:- I , A report by the Director on a discussion with Dr. F.J.C. Roe J A note by Dr. T.D. Day on th~ "Present and Potential ~ouse populatio~ at Harrogate and its distribution" (B 1152 revi~ed): , ~o A paper prepared by the British-American Tobacco Co., incorporating results obtained by m~mbers in testing the physical characteristics of U.S. commercial charcoal filters attazhed to r.& cigarettes (B 1153). Notes pr~par=d by Dr. R.~. ".~crae on his recent visit to the Hicrobiological Research Establishment, Porton (B 1177). ; _ Yours sincerely, : " :_ i .--.------------'------" ."- 2. ,.,,.,/..,:4 S. F. ¥.ilkins, " ........ for Secretary CED O CF~ (DO

TOBACCO RESEARCH COUNCIL Telepbon¢ : To.re G~lee9 204.1 Telegrams : Tobeom. Loudo.. S.W. 1. Glen Hour. Stag Place. Lon don, S.W. t. CONF!DENTT_AL Dr. I.W. Hughes, 12th November, 1964. Dear Dr. Hushes, Secretary's Letter B.A.S.G. 15 I have cleazure in enclosing the Agenda for the Meeting of the Bio-assay Study Group to be held at I1.30 a.m. on Monday, 16th November 196~, at thes~ offices (B ll21). A light lunch will be served. The follc;ing papers are al~o enclosed:- 1 • me 1 ~e e Nose by Dr. T.D. Day on "The ~xperimental Production of Lung Cancer in Animals by Cigarette Smoke Condensate" (B 1120), Note by the Director dated 4th ~|ovembcr on the possible use of Frimates in Inhalation ~zperiments (B 1088). Tzhles showin6 response to condensates during October 196~ (3 lllS) by Dr. T.D. Day. Copy of a letter Crom the Secretary to the Battelle institute Ltd., dated 5th October (B Ii28) and a quotation and description of a project on Inhalation from the Battelle Institute (B ii2&). Article in Nature Vol 20~ cf 7th November 196&, "Toxicity of %Whole Tobacco Tar", by ~rs. A. F!aks (B I127). i, i IResearch & Develo~.m,=.nt [ I ° Yours sincerely, S. F. WILKINS for Secretary Encs. t.P4 CXD CO

TOBACCO RESEARCH COUNCIL Te|epbo~¢ : Tare Gel|ePtj 2041 T¢legreu~s ; Tobeom. Londou.S.W[l. Glen House, Stag Place. London. 5.W. !. 11th November 196~. CONFIDENTIAL • .o Secretary's Letter - BASG. I,/+ The agenda and further supporting papers for the meeting of the B~G at 11.30 a.m. on Monday 16th November will be sent to you tomorrow, meanwhile I have pleasure in enclosing the following papers for your information:- Two extracts from a Report on Research into Smoking and Health in U.S.A. by the Chairman and the Director (B 1052) - (a) Discussion at Sloan-Kettering Institute (b) Discussion with Dr. Peter Bernfeld, Bio-Research Institute, Boston. 2) Copy of 196~ Review of TgC Research Activities. (B I050). 3) Paper by Dr. T.D. Day, dated Ath September 1964, on the Relevance of Bioassay of Tobacco Smoke and its Components to the problem of Smoking and Health in man (B 1031). A) Paper by Dr: T.D. Day, dated 15th October 1964, on Testin~ Nicotine as a possible Anti-Carcinogen (B I030). 5) Paper by D~. T.D. Day, dated l~th October i964, on a visit of Drc A. Baveley, Research Division, Philip Morris inc., Richmond, Virginia, (B I028). 6) Paper on a visit to Battelle Institute, Frankfurt/Main on October 23~a 1964 by ~r. J.G. Burgan (B 1075). 7) Copy of Application by Dr. Stephen Black for a grant to cover a light flicker experiment (B 1102) -i - ~j4 oO

87 9) 10)" Report of the work of Mrs. Flaks, Department of Cancer Research, University of Leeds, by Dr. T.D. Day (B 1029). Copy of letter to the Director, dated 5th November 1964, from Mr. W.H. Walton of the British Occupational Hygiene Society enclosing the Preliminary Announcement of the 2nd International Symposium on Inhaled Particles and Vapours (B 1106) Paper by the Director, dated 30th October 1964, on Flue-Cured/Air- Cured Fzrperiment. (B 1068). Yours sincersly, H.B. @rice Secretary. O L~ Cr~

• • t TOBACCO RESEARCH Tdepboae : T~tz Oallee.g 2041 Tell, Tobcom. Lonclou.S.W.l. COUNCIL GIz= Hous¢, Stag Place. Loudoa. S.W. L 16th October, 196~. C0NFIDENTZAL Dr. I.W. Sm~es. Dear Dr. ~e8, S~cro~ar~/'s Letter B.A.S.G. 13 A o~Ao.._n~ pzpors for your L-Iormation:- I ha,to pleasure in enclosi.ng the ~ ;" '-~ -" io A note hy the imperial Tobacco Co. on the Spoc~"ication of T.5. Cigarettes (B i022). 2. ~eport on his -isit to the S!oan-Kottering Institute on 25th September !96~ by ~. D. Thorowgood (B IOO0). 3. A reporz ,~tcd 7th October 196a hy Dr. T.D. Day (3 999). Tables sho~;ing response to condcnsates during August (B i0!i) and September 196/+ (B i001) by Dr. T.D. Day. Yours sincerely, for Secretary ~CSo P, ese~rch & Development [ 1 ? OCT Ig64 ~i': ......... , ....... ' • ..--. : ...... * .°.... ........., ....... . ........ . .... t CD Cr,

TOBACCO RESEARCH COUNCIL Tek,'phone. TuteGell~}.j 2041 Telzpvmn.s: Tobeom. London, S.W 1. Glen Hour, Slu9 Placc, Lom:lon. S.W. 1. CONFIDENTIAL 18th Septemcer 196A I Seoretar['s Letter - BASG 12 I have pleasure in enclosir~ the following papers for your information:- i. Minu%es of the 3rd Meeting of the Bicassay Study Group. (B 956) t Copy of a letter to the Secretary from Dr. T.D, Day dated 1Lth September 196&, answering points r~ised at the Bioassay Study Group Meeting held on Thursday 3rd September. (B 960) 5. Revised Charts of Tumour Bearing Mice. (B 961) Copy of z supplement to a proposal for research, from Prof. L.F. Lamerton and Dr. F.J.C. Roe dated September 196~ regarding the setting up of a "Unit for Inhalation Studies" (B 962) and an acknowledgement by the Secretary dated 16th September 1964 (B 968). ,J Research & Oeveloorner.t Rc.:d: 2. ~ SE P 1964 P.c:. ; .......... .~-:, !: . .................... o. ....... .... ........ ~;;~, , Note by Dr. A.S. Milton dated 15th September 196~ on his recent visit to Mr. R. Goldhamer. (B 965) Yours sincerely, S. F. Wilkins for Secretary w o t~ c%

TO BACCO RESEARCH COUNCIL CONFIDSNTI~L. "'" Dear 5~. Tel~l~.e : ToI~GaU~3 2o.i.1 Tele 91"0.,.s: Tobco-,. 1,o 2-~ =. S ~ ! r_!~. 13 S £ P 1964 .::_ .-... .... • 4oo~.~•...•ooo,.. ; t • .... ooop•°,., ....... ----, ~ :" Gi=e House. 5tagPlac¢, London, S.W.L. 15th September, 196&. I have pleasure in enclosing the following papers for your information:- i) Cogy of a letCer to the Secretary dated 19th August 1962 from Mr. B. ~riarzy on total stocks of cigarettes (B 866). 2) Confidential Interim Report dated !gth August 196& from Prof. F. Dic~cens (B 867). 5) "Final plan of the Neutral Fraction Experiments: ~Rce IC!/SPF" by Dr. F.J.C. Roe (B 953). &) Note by the Director dated ist September i~6~ on a discussion with Dr." Dontenwill (B 8~7). 5) Copy of Arzicle in Canad/an Medical AssoclaZion Journal of August 22nd 19~4 entitled "Safer Cigareztes" (B 901). 6) Report by the Director dated 3rd September 196~ on a discussion at German Forschungsstelle (B 911). 7) Paper by ~ynder, Goodman and Eoffman on Ciliatoxic Components in cigarette smoke (B 894). 8) Copy of l~ter and enclosure to the Secretary from Dr. H. Elmenhorst on Chemical Analysis of smoke congensates Blend B and Folie B. (B 93~). 9) Confidential Interim Report by Killer, Dukor and Grant for 1963/64 on "Immunology in relation to lymghocytic leukaemia and cancer in mice" (B 939). i0) Letter from the Secretary, dated 26th August 196&, to Dr. A.N. Worden, Huntingdon Research Centre, (B 878), and Dr. \:/orden's reply ~ated 12~h September 196~, (B 952). CD C~ ~4D

° o ~. -2- ll) Letter to the Secretary dated 2nd September 196@, from Dr. R. D. Passey enclosing article entitled "Biochemical Effects to Tobacco Smoke and Nicotine Inhalation" by Elson and Passey (8 932). Yours sincerely, o S. F. l.~ilkins, for Secretary. QJ~ Cr~

TOBACCO RESEARCH COUNCIL Telephone : Tale Galles-t:j 2041 Glen House. TelegPams: Tobcom. LoDdon. S.'~.I. . ~i Stag Place. [.-.,,. ~. & Oc._.o.m-nt ~ Lo,do=.S.W.t. ,...,.. . .! f" rG ! t 'i ................... ' ....... ~ 25th august, 196~. CONFIDENTI~ | ~" ~ '-- ................... ' / '~. Dear :_-r. "'.:_'h.,-~., ~ _ ., J Secre~Pz-j's !,=+.t ,r - B/=~['- i0 I enclose the Agenda for the Meetin~ of the Bioassay Study Group at 11.30 a.m. on Thursday 3rE September, (B 868). ~'-lso enclosed are the followin~ papers for your information:- i. Minutes of the 2nd M~eting o9 the BioJ)~ssay Study Group held on We~Inesdey, lSth July ]9~4. (B 752). 2. Report on a visit te the l~,%ttel]e Institute by Mr. J.G. Burgan cl~.t?d 10th bA~:~t !961~. (~ 821,), 3. Copy of letter to the Secretary from Prof. G.A.H. Buttle dated 7th August 19~ ~_nd article published in "The L~ucet" on rat exp=riments. (B 841). 4. Copy of dia~ams and photosr.~,ph of the Leuchtenberger Smoking Cha~3oer. (8851). ~. S~r of discussion between Dr. A.S. Milton and Prof. R.E. ~~~~ Gosselin on Ciliary Activity em~d Mucus Flow in Mammalian Respirate.~r Tract. (8855). 6. Visit to the Food and D~ag Research Laborator~-es Inc., Maspeth, New York, by Dr. A.S. Milton. (B 856). ~ ~5" 7. Visit to Ce!~nese Corporation of,,merdca, New Jersey, by Dr. ~ A.S. Milton to ~iscuss work on cilia with Dr. %~aller George (B857). ~~ 8. Recommendations for work to be carried out by T.R.C. on cilia by Dr. A.S. Milton. with Renort of ianerican Societies for Experimental ~o~o~. (B 8581. ~ 0. 9. Copy of letter to the Secretary from Dr. T.D. Day dated 13th August 1964 on Modifications to existing imimal House (B 835). " 1/I0" Paper by Dr" A'K" ~it'~g~ aate~ 2&th'~u~ust I~6i On HarrO~teCilia Progr~ (B 862). Y ours ~c er~ !y, H.B. G~LI CE Secretary. ~A~c s. O O ~4D

TOBACCO RESEARCH COUNCIL Telepboaz, Tree Go.lily 2041 Telcgeams, Tobeom.Ii ,_ana.~W.l. ~.~,,.'r-h ?. ~e'.'~'..~-'-~ CONF~ ~TLJ~ ~r. 1.7:. Hu~,',es ° GI~ Bourne. Stag Place, , "} London, S.W.I. 2.0th ..u~st 1962, i i . ° . .°o° ..... °.o ........ ..... • ..,eo. ........ • | I , ;'!s. J Dear _-:r. :-:u:.-',_-..~, i ................................ S~cz~t~'y's Lott~r -~" ~, I l~v~ plc-'~uru in unclosing th~ fullo~,-ing papers for your information:- 1. Report from Dr. T.D. Day for July (B 812) me Copy of letter to the Secretary from Mr. D. Thorowgood dato~ 30th July 196~ on his programme for proposed visit to J~crica (D 804) 3. Coi-y cf letter to thc Secrot~_~y from Mr. J.,',.. Gordon d~ted 6th August 196~ on T5 cigarettes (B 813) Confidential Interim Report .]=ted 10th August by Dr. F.J.C. Roe on Projects supported by the Council ('3 81L) Confidential Interim Report i~tad ..ugust 196~ by Dr. R.J.C. Harris on Smoke Inhalation Expcriments on Virus-lnfocted Mice (B 815) 6. Rc~ort by Dr. V.D. Tughan on a Visit to iluntingdon Rcsuarch Centr~ dated 7th ,~uGust 196~ (B 822) . Copy of l~ttor to th~ Secretary ~atod 12th J, ugust 1964 frumMrs. ,% Flake on progress of mouse ~xpu~m~nts (Z 831) . Copy uf ~rticle in Citizen - News, Los Jmgeles, &.-tud 15th June 1964 entitlu& "Tobccco Lllergy Suspcct in Stroke." (~ 799) Encls. Yuurs aincoz'ely, Meetings Secretary O ~O

TOBACCO RESEARCH -COUNCIL Tdepbone: Tat~Gmllcz.9 2041 Telzg~s : Tobcom, London, S W I. Glen House. Stag Place. London, S.W. 1. CO~,,~I]~ENTIt~L Dr. I.W. Hug2nes 31 st July i 96A. Dear Dr. Hughes, Secretarz's Letter -BASG 8. I have pleasure in enclosing the follo~ng papers for your information:- I) Statement for Background Information on "Enzymatic" Fermentation of Tobacco by the Director. (B.767) 2) Four graphs by Dr. T. D. Day showing tumour bearing mice. (B.783) 3) Note by Dr. H. R. Bentley on Proposals for Skin Painting Tests ~th condensates from Low Tar-Normal Nicotine cigarettes, agreed at a special meeting of T.S.C. members on 29th July 196~. (B.786). ! Paper by Mr. W. S. Paige date~ 17th July on Design of Bio-assay for LowTar- Normal Nicotine cigarett-~. (B.789) Yours sincerely, D, , ,n - Research & evelopm~ t. ____~ .................... i ....... .////;/;i/;/i / i/ I~.~t S. F. WILKES, ,,-~d" "t :',~,... Meetings Secretary. "---" u. ,:Jl3 1~I~ - ... : ~.. __.*.m .oo°~-o.~......,ee,~ .-~-'-..,,,e,,.o,~++o ...... ,~oe CD ,-,--,b ',0 ",U

,- ° . • " # TOBACCO RESEARCH COUNCIL Tdepbonz : Tale Gcsllcs-9 204.1 Tcleg,,~nns, Tobcom. London. S.W. 1. Ol-'- Ho~s¢. Stag Place, London. S.W.I. CONFIDENTIAL 21st july 19~+ Dr. I.W. Hughes Dear Dr. Hughes, Secret-~V's L~tter - ~"~SG i have pleasure in enclosing the following papers for your information:- I. Note on a project in Exfoliative C~olcgy of the respiratory system dated 13.7.6~ (B 715) 2. Note on a Pharmacological Progr~mme on Cilia by Dr. A.K. A~mitcgs (B 723) 3. Note on a discussion ~,~th Prof. R.D. Passey by the Director on 15th July 196~ (B 7~4) Asbestos: (a) Memorandum to the T.R.C. from Dr. F.J. Roe on Asbestos oxposure and Cancer (B 7~5) (b) Papers on ~bestozis ~nd Canc&r of the Lung 1959-196~ (B 7~) 5. ~xtrac2t from a discussion with Dr. F.J. Roe by the Dirmctor on 26th February 196~ (B 7~7) 6. List of proposed members of T.S.C. & Study Groups (B 599) & Researc.~ & DeveloDroent 24 JUL I964 [<': : ... . .~ • ,, .......... o,o,,,o,.o,, ncls. Yours sincure!y, S.F. Wilkins for Secretary o I cr~ C~D

TOBACCO RESEARCH Telzpbo~e, Tal~ Gctleeg 2041 Telcgt.cans, Tobcom. Londou.S.V~.L COUNCIL Ole~ Housz. Stag Place, Loadoa. $.~V. 1. Dr, I.W. Hughes, Dear Dr. Hughes, Secretary's Letter -BASG - 6 I enclose a paper by Dr. A. K. Armitage on a Pharmocological Programme on Cilia, for today's meeting. (B.723) ~Sth July, 196~. Yours sincerely, S. F. ~£LKINS, for ~ecretary. O CY~

TOBACCO RESEARCH COUNCIL Telephone : Tal~Galle~-tj 204l Telzg~ms : Tobcom. Londou. S.~. I. Gle~ House, Stag Place, London, S.W.t. CONFIDENTIAL. lath. July, 196~+. Dr. I.W. I4ughes. Dear Dr. Hughes, SecretarT's Letter - BASG 5 I have pleasure in enclosing copies of the following papers for the meeting on Wednesday, 15th. July. i. Agenda (B71K) 2. M~utes of ist. meeting on 18th. June. (B712) 3. Inhalation Studies - letter from Battelle of Frankfurt dated 6th.,July. (B697). Letter from Dr. F.J.C. Roe dated 8th. July. (B707). 5. Cytology Project - Two papers. (BTIS/BTI6). 6. Summary of T.R.C. Research (B713) 7. Dr. E.L. ~ynder - Three papers. (B696/B710/B720). 8. Five papers on matters arising mut of the Director's visits abroad. ~B533/BS~7/B588/B611/B613) Yours sincerely, S.F. Wilkins, for Secretary. Encls. 0 0 0

TOBACCO RESEARCH COUNCIL Tdel>hone : Tote Galieeg 2041 T¢legeams : Tobcom. London. S.W.t. Ol~ House, SCag Place. London. 5.W.I. CONFIDENTIAL Dr. I.w. Hughes { ; ! lOth July 196& Dear Dr. Hughes, Secr~tary'~ Letter - P#~ZG I wish to confix~ t~mt thu next meetin~ of tne Bioazsay Study Group will be held at 2.15 p.m. o~.l WedLesday l~th July 19&%. The a6ez,da ~.-ill follow. The following papers ~'e enclosed for your information:- le Four graphs by Dr. Day describing progz-ess of main mouse experiment (B 678) o Proposal from Institute of Cancer Research regar~ling the satting up of a "Uz~it for Lnhalation Studies" (B 688) 3~ Paper by Dr. Day on development of provision for Short- term Testing at Harrogate. (B 689) Encls. Yours sincerely S.F. Wilkins for Secretary res,,___V.h r:.- 14 L ;-/,J, [~" ~:~ : O O L/4 O

TOBACCO RESEARCH Telelpbone : Tak GallerN Z041 Telegrams = Tobeom, London. S.W. 1. COUNCIL Glc, n House. Stag Place. London. S.~V. I. Dr. I. W. Hughes. : 8th July 19~. Dear Dr Hugh~s, Secret~'s Letter - ~'~G 3 ,Dr. J. B~ffinger L copy of a iott~r t~ th~ B.M.J. by Dr. J. Bcffinger is ~nclose&. A reply, inte,~ied for circul~ti~n t~ selected scientists as back&Tuuuld i:~fo~ation, ~ud a covering l~ter to the scientists ~rc also cnclosea (B 691). The scientists selected would include members of the "Plannin~ Committee" and others who a~ leaders in the field of smoking and hu~'/th rose-rob. It is not proposed to publish tluis background state- ~er, t, .. If it becomes nuuessary to publish a reply tc Dr." Leffinger, a shorter documant would be prepared. ~mClS. Yours sincerely, S. F. Wilk~ns for Secretary. 9 JUL !%4 S?~_'I t:,' : ..................... .o.o•o.° .... ...o, ..~ ' File: .................... 0 0 £24 0

TOBACCO RESEARCH COUNCIL Telt-jpbonz : Tare Galleeg 2041 T¢legt-ams : Tobeom. London. S.W.I. CON ~-ID~¢TL'.T, Glen House. Stag Place. London. $.W. 1. 7th July 1964. Dear Dr. Hughes, 5io~,~say Stud.*., Grou;" -L(Lcttor LSG 2) I h~.ve ~lo=sure in anclosinc the following pc.pers for your informr.ticn: (I) L letter dates 19th June on the l,rogress of buildiruds ct Harrocatc (D618). (2) L lct¢~r and note cn Dr. Schicvelboin dated 17th June from Dr. ,~rmit~ge (B 622). (3) Note by Dr. Day dated Z5th June on the visit of Trcfosscr Krccht (363~). (~) Netc by the Director on ~- "discussion with Dr. F.J.C. koe on 26th June (b668). (5) Note by Dr. Day "~mim~-ls ~n ~-_~q, oriment - July 196&". (~ 675). (6) Letter to th~ Director fr~u Mr. D.A. Cculson dated ~mfi. July (Z 6"/6). (7) Letter to the Director frum Professor L. Haddow acted 3r~ July (r, 672). (8) Note by th? Director cn n iiscussion ~vith Dr. E.L. ~ynder on 6th July (~ 681). I i ~tll o~sJl Y~urs sin ccroly, S. F. Wilkins for Sccreta~{. o O

TOBACCO RESEARCH Telephone: Mc~ltair 3804. Telegram=: Tobcom. Wesdo. London COUNCIL 6 - I0 B~oQ S~et. Londo-. W. I. Dear Dr. H~es, ~st Meetin~ Bioassay Study Group - (Letter BeG I) I now have pleasure in enclosing the ager~ia for the meeting of the Bioassay Study Group at 10.50 a.m. on Thursday 18th Ju.~a at our new offices in Victoria: (Glen House, Stag Place, S.W.I.) Also enclosed are the following papers:- N,te on a discussion with Prof. O. Cunningham (~5~) 1 Note by Mr. Todd on a discussion with Sir Ernest Marsaen (B5kg) Q ~iote by Dr. Day on a discussion with Sir Ernest Marsden (B57~) Note of Bioassay Experiments in Progress (B576) 5. Report by Dr. Day for May (B577) ~La,~sincerely' H.B.G. Secretar~ L _ I Rc'~: . ~ ;..., ... 1 ..... t ~ ,j j;'! ."04 { ........... " " •"" " "" " "'i~- c> ......... ,.., ..... ,~ cp J~