Tobacco Documents Online

w~,.% • • • d' ' 8 I~ t yea'r~_tn~ • [I ii i i i ~H~ 5~OLIGI~ff ~tI~a dala~4~Lon Inla~4~Lon o. - | .. - _ "° " o . ee "4-- °. .:d" ...... "d't- ~'~ ...... ~c~ =,~ ~ (~ ,~) (~) =5o ~t ~ (~o ~) (~) ,.~e lovest ome~zstl~=/n the etmsld~ found to be ~ to .~t~ ~, .1~ (v/~) ~ ~.~ ~,,~, .~ 2o ~ (4). ~,~, In z~tn 81~ ooauzz~ vlt~Lu 4 ~tee at 20-~0," ~ v~Lthln 1 ~Lz.~o ~t • ~at (~) ~ aloe 8u~=nbed vLthtn a fw =L-n~w /n sn atao~lw~ the deliberate L~lat£on o~ £mon ];=olm~e, ln~l~tn5 TC~K, t=m ~ ~,c, (o). Sta~eo trl~h aloe, :ate, :rabbles, ~-wdnoa piss, ~ ~ :oni~ have shmm that ~ Is toxl¢ to the narvou~, msFLmtoz:r and ca~t~c- qst~ (4,6). s~t~m or ~t~on ~e ~osm~ve nn'~mLs, v:l.th lou of :ea'lmm, tzmo~, ~ breath.t~, W]WtmLiae, area eezaJ~ azzhT'U~la. Death mmm to be due either 'to ms~zsto~ o: mzd/~ faLl:m, o: • omb~na~Lm of both ((;). ~a Ls ~e4 to be yell tolus'ted by =at ~ (~) although In am st~r repasted to~l~l appllmtl~ of the ~ z~sulted In • ~oool Ls ~Te~ L'~ • mho~ dL~e onto hunn~ s]~bz ~t¢!: ~y len~ 0 0 C~

-S- cans of Lllm omtmt eoum An ~ lsm been et-tTtbu~ed to TC~q used as • Im~J~l]aat An oomuoJal deodomat (11). m~ amain ~'~ .... ".." ...... ---- Fd£d ~tlou of t~ q~tm, IVSmsmm~ aaa laaz',m~Lon zmmlted ~ the apmT/~ of ~ faro the e~e at zsbbllm bat them om~=~zl ~o vss no'.~t vt~h c~t,:Lcm of 10'/,, ,,,, lz:'ltat4on ooc~:ze4 a'c • eouce=l:~.on o/" 1',~ (1). G~r~h, food conmm~Aon, ~'tnalysJ.s and ~.~enatclo.~j were 'unn£foctcxt Ln .--~..tc b:- 4=t1:, ,2.,:coo of up ~o 1/0 of 'the o~1 LD.~O o£ 5 nl/k~ An ]J.qutd pn~-n£fLn did no~ :em~.~ in azr,/' ovt~lc~.c.~ "" !£':~." ~=~,-e (~). Ca~Lmm: e:cj~u_,:o at ~0o0 ~ (0.~:') ~ur ~0 cla~, or nmeet,~ mmo,,~ o~ ~o25o ~ (~.o~,:) ~o= ~ ~=/~, ~ ~w~/~.- for ~ ~eok~ lxeedam~L no visible :lcna of to~J.otty in :at,:, ~ .~..~-, iaonkeys o= ~ (1~). ~ t,~ze vo~ no Id-,~-~e O/'.%ct: an -"~';£'~1, tx~ v~ht, ]~..emtolo;l~t In, Lie, ]j.ve: end.s and ~'unctAon o= t..c ~;~'oc: or .~Lst;o~a~l,~lc:~Loal ]~l/ottz~ o£ m~c:: o~-m~ An m~r o£ these speoAm. The onlM sA~lflcant cban~e ~a an elevated ser~ urea level £o~ in dogz (I~). 5ex~: u:ea levels z~asAned vAthAn nezasl 1J~ts An a late= 12-o~th st=~ In vhlch (l~ ve=e ex~s~ ~st1~, to • lz~lx~llar-% con~Ltnt~ 24.~ ~ (14).

-6- ffemmml oe~e~ an4 ~ vaeuolat£ea ia the bmsla, ew~sem sa4 oe4em ~ ~e ~ ~ ~ hsamto~o~es~ Aa =ate veze a~mA~Ate4 So expommm o1" 12000 ~ (1.2~ ~, 4 ~/~a~ to: 10 a~, (15). ~=~, An aa eszlAe: s~ ao ~st~lo~lesl ttadlnp ~ =oI~-~e4 at 4~vj~e U~at ~,vel o£ ezlmm~ :-tl, ~ ~, or care (16). Pu.lammW i.~z, ttatLon oeem,:~ la a£oe ezpoee4 'to 10000 Plm (1~") cc.ntimAous3~, re= 24 ~ (17). , CcmGu'U.cn and baeaor=b,~,es '..'e=c f~=~. i:~ the l~m,-~, o1" ~ Ides e~mained 8 ~ ax'tez a 2-hm~ ~Mo ~c~~ e~£eeta o£ ~ lz~slatAm a:e s~e~£es ]3~a~hooonst~Lc~Lon ~=, "oecn =ogo~te~L in nice and rats a~ e:.:-pc..m~c o£ 1~,: sad 2..r.,' of ~.'C".: .-c:~cct£vo1¥. '..'.~.c:cav ~mnohod1~t£on oc~ t~ =c~-'.:o:'. .', .-~ucticn L~ Im/:OnL~- cornice occ~ L-. =~,en~=, but not 1,-. t:.e ~e- ::'.:- t::o =er~':~j. t:~-'o:::old level ~.r 2.~',: An :o(lonts, dc:.-. ~s1~Lz~tA~ vu rle~re::e.,. ~t ~'," in I~o aoa~ e~a lO. An "~he 2'C31! e,-r.e~e vL-'£o~ ~a~xAc oL'~ecte o~ the c~ovascuAa_~ ~,~t~ mice ex~se~ So ae:~ee~ of ~ bug +.ac~~ etch_-: ~-- a.-'~e=t!:eti=,~ ~to, ~Lee, 4op an~ ~. Zn addAt£~ tlmz~e a~e obse:vatA~ shovh~ that tnlmlatlon o~ ~" cau=ec h~mtensAon, 4eg~essLon o~ ~oc~-~l eo~c:ac~ilA~y and ~az~a~ ~~tas An ~ese ~es.. Xa ~te ~ conc~t~sti~m~ vb~ch ~ to effect th~ ta~uanc£=g =espAzltAon. ~ =eve'A-se As 'M=ue :Lu cloCJ a~" -..onk:n~ ~s have bee~ ebee~ st leve~a ae ].au as 0.~'~ C r~. c.J- r~_

-7- Dop and aoal~s a1~aa= to be ao~ mmnltA~ to t~ :etwltlvl~j cf the "~e:.-t .-my ~ t~ess~t by taJeol~on of eplne.~, or .-m~cn ~loa=e o£ endo~ eld~. In add~tAor~ ~po~a n~l :'~.'U~pnea m~ £nd~r~t~v ~ the se~AtAvity ~:£ -~.:o .~:t to tho ef£ects o£ ~4 as, £o~ e:=~ple, a Nco~szy ef~eGt of co~ ~mla sa~ o~Ltac ~ci:. "~irensloc~oW, ~-e~e bloeka4e ~d anaes~eala d~p'.~=s '~tm cens£t£vli-~ o£ the ~ to ~Ci.1.X (1~). ~zSA ~o=o= ~ 1~2 and ~2~ q~/4=-y dld not ~ ~ Az~c£'c::co Ln .=:le o= ferule :Aee (20). In s .~:011~1 ~ An ~,~c:...':1o_~_ :: :Ask £~; l~to .Aovelold~ tu~uA= ~ ..... '- ..o_.~ ;=overtime" ~,~--. ....... ,~ ~.n~c~tn;i.- : ~" c~-¢~.nocm~Ac !~tenc;r. ~:o ~tAon ~" .... :~..~ poo: --~_~v~l Imm ..'i:'c-: Ln ll:c .~-~, _,~,-~.-,c-~._: Chrc~to Amnla~ of lOGO0 ]~a (~,~') Im'~t~ no cl~._t- -,,-': :1-..ic~l c~a~ ~ ~'.o (2). dad not :m~l m~r e~£~e~oe of ~:o:oa=~l tmmw fo=uat:Lcm An f~e mlce exposed ~or 22 aoa'Um to 242, ~ ::: "~--./d~j ~'-_.c,~ an ao:osol ~ co~alal~ 2~ ~'~I, 43.~/.--~ooa 12 (~Aehloz~tl- .~J,~e~-lethem), ~ ]Pzeo= 114 (cLtcklozoto'~=.t'luozmrl;tmne) and 1.1~ ~ (~.~om~=ou~r~~) (~4). *mmme, 0 o ~jn --.j

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t -9- /~ of the sab,lecta ~ct ctmmZop ms~,/.m'bz~ sAma and ~ and eaoh e-J~bi~ed • bApbu~ z.ed~MA~ An ez;d~to~ flew =ate (Z.~). YolXovAnC a ~ expoe~ +hem-o ~ a ~msi~or/ ~ach~ vi~b ~Lve ~ 'hmvu An 2 o.f "the ,-,,.~.~ec:: (3o).7 ~_., ~n c~-,lier ~ (]1) no effeet on ~.~_~ ,n~- founa a, rlac o~n~lo o~po.-u~e~ to an a1~o eooo~tlon o£ up to 1000 Pl~ (0.7,.) for up *.o ~ "~ar=. .';o_- ::o~ a.~- other, untovaze, p.~C~Lolo~ical effects noted an tho ~ctAo:'. o~ t'~ heart, lw~: :.= ~..--:cc: ~/:tc=. -'_ _ ".:--.::: ~-'.:"c ~ a n]~L.':~ ~'c.'.3~.c i:: c"-~',I/,.£;'a ~'u,-~:;Acn (]1), ".- ~::::.-..io~,c::Ac ~£~'c~t: ~ ~ou~l Ln 10 :~:tAcn;: ",~.*,.. ~::':~:..---tc--d~Z :~Tc,:"A~ .~eCu~;-,-~'" ...... " .....b_~',,,chol~]J=o~1" " (ta.-c:::v .':=" ~. 1J ..-':~'::", ,, :~:-~c~= 1-~.,• :..: -, ;c." ". ~ :','~;x~11:~; ~.:,'tlL--'e C,~.,~,: '~S.:., .'~ :':-.~.:. 12) Jn 8-bo~ exJx,~ tc al~w~Lm~el:r 1000 ~ ~a= .~c'~c- ",~ Za~la~loa of ~ ~ ~mpeX3a~s A~ a ~o~t fo: ~m do=th of a 4-yoa~ old who oc)An,-mod in a batl~oeu ~ ]he hnd c=@'tiod t~ ccnt~t8 o~ t'-.~ :p:~" (~). Ik~.lucA~ti ~o== duo to the 1.~£on of l~Olm].lant f~om a ~e contaL~ ~L'FJK and ~.-~on 12 ~ve been reported, but nooa ~ ~:it~. ~ec= 12 al~ (y~). b C r~ t.r r~

- 10- L 3w~en ~at!~ ~ue to ~ ~oXAbqn~to abu,~ of ae~sc~. l~opellan~ o oni.~rodL, An hA~ co=o~tzn'~:lLa,~. L'z'on a ]pO.~io ()9), ~na smto.~cJ.~.= .~vo ~.~.~ no amt~cel cl~.e a= :o tlm .~:; ,i~os not ~ec~o~c cn .~u=~ ~ 1~1~ cl~"au~', =o,-~. cf -;" .c:e .~:" ':c--~..--.::"_": ~" "-, t..::, ._~,..'~'~ .... " :: (c:.,!~~.~.z.,': ::,~) ~.z=.:':" ",_,.: (:':). Xn l~bo~oW anlmls, M2M ~Ls o£ lo~ aeuto, eubs~r~ 8n~ ~c ~oxlc£ty ~.~.ho~ e~~ is by Lnha~ o~ v~a ~ o~1 z'ou":e. S~ptom of scm'l~e ~,',t, ozJ~t.tan ~ ]m~mmXve ~=cos:Ls, lou or zetlsxss, t~m~s, s:xt ~ ~t/a, C1~1 e~mm- ~e. Ja~sl ezper/J~s n~oet that enox~ or 1~-e~s~.~ to ~Mf. ~d3at tl~o a~o slpe~tos ~Ltt~ ~n t~ tox:L~tql/a~ ;wo£;IL~ of ~ ~o a(~yo~o o££oet8 harem ~oen obeeL-n~ at the Tier o£ ~o Mm/a am~ e~ tbo anAn~ qooAoe ~t ~. c P~j u'~ (_N Q

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