Tobacco Documents Online

IC l ~"Jt~ON,41iL (:E)llili/k-A-J.,m~ O,]N SlilOirJ:NG. l[881JlE8 July 16, 1979 RUE MONTOYIm 10 BOX No. 2 1040 BRUSSEI.8 BELGIUM TEL : 811 91 10 TELEX : 24216 Mr. D.G. Felton Group Research i Development Centre Brltish-American Tobacco Company Ltd., Regents Park Road Southampton SO9 1PE England Dear Geoff, Thank you for your letter of 3rd July and your very kind assistance towards the setting up of the ICOSI library. We have just received the publication on your International Conference on Smoking Behaviour, which is a valuable contribution to out library. With kind regards, Yours sincerely, cc: Dr. M. Senkus | ; , I .~ -- L | J O O C~ C~ C-_D CD

6~3 :;F IV'.,TI.~ L PP~r E~: Dr. Dr. Dr. Dr. D~.. Dr. D. G. rol~on (~%T) C. ~. L. F~tc~att (CazT~r~z) F. G. Co].~y (R. J. R_~yncl,/~) H. Gaizch (Philip T~c.,T_is) K. A. I',e]oh (~:ec=tr"-) ~. 0. Fief& (G&llaher) Mr. 3..'~. =st (CaaTeras) Dr. ~..'. Ciapp (R. J. Reynol~.") Dr. ~".11 (re,Jr---a) ~. c. D. Drig~ (Gall~er) i. 2~ I£inute-- o£ mee~i~ in 6-¢l~-'b*tr~. • ~nese weze aff:~ed. Te_-~___.%s of Reference. \ ~ne Cha/msP.n re uorg+d on decisions zo&ched at the moetin~ of the Co,.,,~rnors of ICOSI on 12/I~%h September, and subsequently, in re~ard to the altered stFle and te~a_s of reference of ~e Group, nmaeiy, (a) that ~e Group woul~ now be styled "the Scientif,_". and Techni-=l ~dviSo~T Group", that its terms of reference would be "to advis.- th-. ~oard Of Governors el" ~e Exccutive Commits.so c-n amy t~chnical and scientific era.tier refezTed to it by oi%~er of these two bodies". T,'e Chairman explained the hack~zound to ~is revised style and teras of reference and summa~ised the reason un~ozlyir.E the T2LT~e technical and scientific issues which have been re/erred to the Group. S~oke Consti~uen%~ in Ambient A~,mospheres - Tecb.n/cal Anoects. Nemb~rs r-.~o_~te~ progress on this matter since the date of the last meeting as follows. BAT reported that, because of a change of policy, they will be carrying out no fumther wo.~ on ~e~.s,~ing nitros,jmine~- in -:mbient ~tmospheres. They also table~ a report on this topic ~y BZ3RA. /'" C) 0% Cr~ CD

-- 2 -- Philip Morris ~x't~ that £uzth~r work had indicated that the concentra- tions of nitrosamines in ambient at~onpheree reported by Brqmemann h~l been confirmed as being approximately correct. There v~re indications, however, that r itrosamines in atmospheres in which ci~nrottes were being" smoked might not have been £ormcd entirely during combustion, but might arise partly from secondary reactions between oxides of nitro&,en and constituents of the aerosul particle phase. Further work on this problem will continue. Carrezas/Rothman reported that plans for further work we-~e .suspended pending delivery of the ICOSI sampling device. Reemstma reported that they hoped to be able to deliver ICOSI sampling devices to members within the next 3 or 4 weeks, in addition to the sampler already available for Imperial. A report was tabled detailing measumements already carried out on ambient nicotine levels in smoking and non ~,.okLn~ environments. R. J. Reynolds _~ported that measurements of nitrosamines in "normal" air showed levels not d/seimilar to those reported in smokin~ environments. R JR will consider what further studies are needed when they hzve h~d delivery of the ICOSI sampler. No fltrther lCOSX-rolated work is planned with the S~anford sampling device. Gallaher reported that development of methodology for estimating NNN has com tinued. Imperial reported that no work had been commenced on measurir~ smoke " constituents in ambient atm+ospheres pending delivery of the ICOSI sampler. A literature review of tobacco - specific nitz~zamine~, was circulated. The Group noted no further progress had been made with methodology for measured particle matter in ambient atmosphere; this topic was not, however, regarded as deserving high priority. 4. The Relative lmoortanco of Tobacco Smoke and Other Sources of Volatile Nitrosamines in Ambient Atmosuheres. The Group noted, (a) *.he BI3P~ report from BAT and (b) a commentary by BuR on this topic, including an official report from the Environment Protection A4ency in U.S.A. After ~ull discussion it was a4~eed, (i) That the quantitative estimates of the contribution from ci~ette smoke sidestream to volatile nitzosamines in ambient air were essentially correct. (ii) That it could, therefore, not be disputed that ci~rette smoke si~- stream contributes nitroeamines to ambient air. (iii) That current evidence would sugEest that cigarette smoke is an important source, compared with other possible environmental sources, of volatile nitrosamines in ambient air. oel cD t,,-J C~ 0

e -3- (iv) TL~',t thv litcn.turu i~;.m which this ccnclusic.n iz h~.'ed ~:l~y not how~v,,r b~. r.-:li~b).c bccau::.~, (v) (vi) (viA) (a) .~::~.~ of it pre-dztoz ~.b" dcvolopucnt of moac~., arm.!yticc.l tcohni,.it~cs [or "~Z"CUI'-:k~" volati!,- ni tro~-'-a~incu, (b) the literaturu does not p~y =e~::d to all pot::nti~l sou--ces of 7ola~iln nltrcsa-ninus ~:d situ:,.ti~nz in whi:h contamination of atmozphcl, c-2 b~- t/iu,~ com~nz could -v_Ti::e; recent cvi,~ence ~uco-ests ',',hot there z~v be -many Dotc.~:ti.%lly impor~,t zcurcen of exposure of iz,(livid~Is to vo].atilo nitros,muines. The current evidence is insufficient to p~ovc whether or not th~ levels of nit..c=-_mine present in ambient atzoslaheros, arisin:-U from cic:,ret~e s.,.:okinC or oth~r nou,_~es, are haz--_ful. On the othex- ha.nd, there i~ cur. i~.iniy ~.~, c~:i~cnce th~.t thg.~e levels are h~..r:~luzs: and there is zc~o evidcy.cu ccnsiGzont %.,iL.h ~.e hypothesis ih~.t the)" may con~.titut9 a l,azami fro~ c~m.::er in nu.-..e-~ou:~ or&'~Lnc. That nothing is yct ~no~.m with any cectain%y about the ~clat£vc contributions to tb': total body buz~,en of nitrem-~ines from envi~or.~::nte,) and endogenous scuz~zes. That there are ex~ples ~ere legislation imm already been invoked to reduce enviro:men%~l exposure to nit_~osamlnes to levels ~ich, if attained, would in fa~t be lower th-~n those levels to which non smokers mi~:t be exp~e~ in environmcnts in which cigarettes were being smoked.= Hum-m Smo.~.-iz~ Cha_-v..~cteristics The Grou,n co.n=idoz~d how to resnond to the wish~ of the Governors to h~v~ further information on the way in which individuals smoke ci6mrettes. It was agreed, (1) That some methodolo~ for Anvestigatinghuman smoking habitm was already available. EAT h~ve develop?d appar=tus for measuring human smoking bohaviourand for reproducing thi~ experimentally by me~m of a puff duplicator. The apparatus required for this Farpose can be purch~ed from CGC Ltd., of O,eltenh~m at a cost of approx_i- mately £35,000. (ii) Gallaher reported that they have ordered this apparatus. That information acquired by this means would not provide £ru'orm~tion on the depth of i~alation of smoke constituents subsequent to the act of taking cigarette smoke into the mouth. Experimental approaches to this problem mi~t include, (a) linking ~formation acquired thzough the use of the smoking behaviouz monitor to mea=urements of cazboxyhaemoglobin, (b) similarly linkin~ infor=ation acquired with the smokJ~C behaviour monitor with measurements of eydmled carbon mor~xide, (c) measurements of concentrations of nicotine or its derivatives in the blood as an indicator of retention of particle phase. Accordingly, we recommend that ICOSI member companies separately, or through local Trade Association, might commission further work. 15.11.78. O O CD