Tobacco Documents Online

3.;,.T.. ~, & D, CQ:".~Z.RENCE - .~:;O.~:72_~,%~ October 24 :o 27 1967. Present: Dr. S. I. Green Sir Charles Ellis Dr. D. G. Felton Dr. R. B. Gtifflth Mr. L. C. LaporCe Dr. R. A. Sanford Dr. F. Seehofer Mr. H. E. So.off Mr. R. S. Wade Conclusion a.t3.d Recommend-3tlons = , . The maLn conclusions are as follows: e Company scientists should be fully involved in the formulation of company policy in the field of smoking and health. . 6. Smoking is now irreversibly associated with health. More legislation and governmental control can be expeczed. Lessons can be learnt from the Strickman affair applicable over a wide range of activity. Some attempt Jhould be made to establish the optimal levels of nicotine for smokers, to develop low T,P,M. normal nicotine cigarettes, low T.P.M. low nicotine cigarettes, predominantly health-orientated cigarettes and to consider more radical approaches to smoking devices and non-inhalable cigarettes. Montreal and Hamburg will seek approval to develop a cigarette made predominantly of locally produced reconstituted tobacco. Southampton will develop a cigarette incorporating all factors considered of importance la blo-assay and aim to have it tested biologically. e Biotes%ing of Company products should be liraited to products believed to be completely developed to a viable saleable proposition. ..=...a. O

- 2 - Q . I0. II. 12. 13. The Companies of the G~'oup ace generally weak and ,n~lnerable in the development of conventional ci~'~ret:es. We should examine the a.opltcatton of scien:ific work to these problems. The closest working rel.~tionshlps with those e.m, ployed in marketing should be established. Knowledge of the technical details of how people smoke could be of great value. The attention of microbiologists w~.thin the Group should be drawn to the possibility of the necessity for microbiological production control. The I00 mm._cigarette is probably in entirely the wrong direction. It could, however, provide an opportunity to introduce extra long filters. It was conctuded that members had found the conference useful although the criticism was expressed that there had been insufficient detailed co-ordination of work progra mines. There should be further conferences of this nature and the majority present thought that the next meeting should be within the next six or seven months. CZD CZ>

- 3 - 1. C, b Cec;ives of t~e.Cor~ere..nce Dr. Green outlined the objectives of the conJerence as follows: a) b) To -. :~ine the research and development ec'.tv[t7 relevanL to the Companies of the Group. To ',den~Jfy the main assumptions implicit tn present actlvtties. c) To identify the maLn objectives of research and development and to recom,'~, end any desirabIe changes in objectives or procedure. He pointed out that the objectives were yew broad and should be construed to include other research cent.~es such as Harrogate. Although add~.tlonal topics could arise ~rom t:me to time, two major themes had been Isolated, namely smok'.ng and health and product development. 2. The meeting approved the agenda structure, after a "= short discussion. 3. Assumotlons Constderable discussion took place on the assumptions made by R, & D. scientists and these were listed without any attempt to justify them or to agree on their covertness at this time. as: Of the assumptions listed, the main ones were Identified Research can be profitable. b) c) There is a m~nimum necessacy Level of ulcotlne. Smoking Is a hablt a~ributable to n~cottne, The form o~ nicotine affects the race of absorptlon by the smoker. Smoking and health problems are susceptible to a research solut¢on. d) e) If there is no inhaling, there is no lung cancer or respiratory disease. Smoking has both physiological and psychological effects.

- 4 - O --I g) h) There will be more gove.,~.,..ent involvement in :he tobacco :ndus:cy in the future. ,~omo-n,/ ncn--..edlcal scientists are capable o£ making judgements on health matters. Selective :iltrat!on of non-volatile =atertaIs is possible (i.e., aerosol particles are chemically inhomogeneous). i) Smoking and health matters cannot be entirely handled by legal and politlcal moves. 4. The Presen'. En-:i.-onment A nu.-.~er o: factors were listed as being "~hose affecting R. & D. activity but over which we have little or no control. The me,lot ones were as foll.~ws: a} Le.,'~_[ and oo!i'~:cal =re_~su:es The meeting heard summaries of the American, Canadian and German positions and %*late unanimous in reaching =he conclusion that the technical position on smoking and health is hecon~ng increasingly complex and that the companies' scientists should be fully involved in the formula- tion of company policy in the --'ield of smoking and health. Sir Charles said that in his opinion, 1:he industry should atter'.,pt to seize the initiative by some positive action. A number of suggestions were considered and it was felt generally that some attempt should be made at the appropriate time to bring together the £ndust.-y scientists in the U.S. in order to explore possible action in this field. Dr. Griffith cited examples of the U.K, and especially Germany. It was also agreed that company scientls:s can provide a positive approach in contacts with public authorities. It was agreed that smoking is likely to be associated with health continuously in the future and that it was not a passing phase. !t was likely, moreover, that tobacco would be involved in legislaclon of a food and drug administration nature in respect both of product and of manufacture. The German situation regarding pesticide on tobacco's indicative CZD <Zz)

- 5 - "Ib b) c) o.~ :~is trend a!though tobacco ~n Germany a~re3dy comes under the .~ood Iaws. The meeting d~cussed Amcel's smok%ng mate.-'.al S.V. and I.-..petlai Developments. The position may be reached within a Fear o: sO where Celanese Corporation of America may attemp: to exert, pressure through the public authorities to get their pzoduc~ incorporated into cigarettes. In chis connection, it was considered that the presen¢ arrangements were satisfactoc7. The present arrangement |s that B.A.T. (A~illbank) ere in touch wlth Amce! and have a rela~ionshlp which Is 'warm' but llmlted to supplier and possible consumer. R. & D.E. ate testing SIV~ materLals a~.d Amcel undertake ~o keep us fully ~.nfon.,ed and not to disclose publicly without prior consultation. There were reports that Amcel had recently made a "technologlcal break- through", and if this were the case, both Germany and Canada wlshed ¢o receive samples through ~V.iilbank when these become available. Germany would also l~ke a small quantiW of the curren~ product. In the case of Imperial Developments the problems of communication were clarlfied. Because of the A.M. & F. license to I.T.Co. (G.B. & I.), Dr. Green undertook to get further clarification with respect to the provision of information to Br~.stol of new developments on PCL in Canada and America. External Research -m.,'osrammes It was agreed that such programmes as ~hose at the U.-.'~vers'.ty of ,~entuc~" and at the Environmental Health Unl¢ a~ Research Triangle, N.C. (.~o~In) will influence company research" programmes and may also have other effects. For example, the fact that they will of necessity, publish their resul:s should le~d to a reconslderatlon of our own policy on publlsh~ng arid it was agreed that where results which we had obtained were l~keI7 to be covered by such publications, we ourselves sho-~d publish ~irst. ~t was also agreed that we should co-operate in such programmes CD <ZD