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ftflONDAY, SEPTEMBER IS SYMPOSIUM 7-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM CELL BIOLOGY AND CANCER Chairman: John Carrns, M.D., Ph.D. London, United Kingdom EVOLUTION OF THE MALIGNANT PHENOTYPE IN AN EPITHELIAL CANCER AS SEEN IN THE CASE OF MOUSE MAMMARY Daniel Medina. Ph.D. Houston, TX SUPPRESSION OF MYELOID LEUKEMIC CELLS BY BIOLOGICAL REGULATORS Donald Metcati, M.D. Melbourne. Australia CELLULAR AND HOST ASPECTS OF TUMOR METASTASIS Garth L. Nitolson, Ph.D. Houston, TX HIGH EFFICIENCY, KINETICS AND NUMEROLOGY OF TRANSFORMATION BY RADIATION 1N VITRO Ann R. Kennedy. S.D. Boston, MA STATUS OF STUDIES ON THE EXACT PHENOTYPE OF CANCER CELLS Robert Poilack, Ph.D. New York, NY te- MONDAY SEPTEMBER 15 SYMPOSIUM 8-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM PREVENTION OF CARCINOGENESIS Charrman: Lee W. Wattenberg, M.D. Minneapolis, MN CHEMOPREVENTION OF NEOPLASIA WITH RETINOIDS Michael B. Spom, M.D. Bethesda, MD BLOCKING OF TUMOR PROMOTION BY PROTEA$E INHIBITORS Walter Troll, Ph.D New York. NY INHIBITION OF FORMATION OF CARCINOGENIC NITROSAMINES AND NITROSAMIDES Sidney Mnvish, Ph.D. Orrraha, NB COAFE'€ BREAK REDUCTION IN THE FORMATION OF MUTAGENS AND CARCINOGENS IN THE LARGE BOWEL OF MAN W. Robert Bruce, M.D.. Ph.D. Toronto, Canada DIETARY, FACTORS IN THE CAUSATION AND PREVENTION OF NEOPLASIA John Weisburger. Ph.D. Valhalla, NY 5228 -t9

RAOIiIOAY, SEPTEMBER 15 SYMPOSIUM 9-Empire State Ballroom B Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM ADVANCES IN DIAGNOSIS Chadrmen: Daniel 6. Miller, M.D. New York. NY Sidney J. Wmawer, M.D. New York, NY BIOCHEMICAL AND IMMUNOLOGIC DIAGNOSIS OF CANCER Morton K. Schwartz, Ph.D. New York, NY NUCLEAR IMAGING IN CANCER DIAGNOSIS Henry N. Wagner, Jr.. M.D. Baltrmore, MD RADIOLOGIC ADVANCES IN CANCER DIAGNOSIS Michael Deck. M.D. Nsw York. NY COFFEE MEAK EARLY DIAGNOSiS OF LIVER CANCER AND ITS PRECEDING STAGE THROUGH AFP SEROLOGY Sun Tsung•Tang. M.D. 6eq!ng. People's Republic of China CYTOLOGIC ADVANCES IN - CANCER CONTROL Myron R. Melemed. M.D. New York, NY ADVANCES IN DIAGNOSIS OF GASTROINTESTINAL NEOPLASMS H. Worth Boyce. Jr., M.D. Tampa. FL I RIOTES 5229 . .. . ~ -u~. .__. -21 I

TUESDAY, SEPTEMBER 16 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Vincent T. DeVita. Jr.. M.D. Bethesda, MD C Chester Stock. Ph.D. New York. NY 8:30 AM DEVELOPMENT OF,ANTICANCER THERAPY C. GordonZubrod, M.D Miami, FL 9:10 AM Li4BORATORY METHODS FOR THE DETECTION AND DEVELOPMENT OF CLINICALLY USEFUL ANTICANCER DRUGS Frank M. Schabel. Jr., Ph.D Birmingham. AL 9:50 AM PHARMACOLOGY Emil Fret. III, M.D. Boston, MA 10:30 AM COFFEE BREAK 11:0D AM PEDIATRIC OVERVIEW Denman Hammond. M.D. Los Angeles. CA 11:40 AM LEUKEMIA OVERVIEW Joseph H Burchenal, M.D. New York. NY 12:20 PM CARCINOMA OF THE BREAST Ganni Bonadonna, M.D. Mdan, Italy 1:00 PM LUNCH IUESDAY, SEPTEMBER 16 SYMPOSIUM 10-Terrac.e Room Lobby Level Roosevelt Hotel 2:00-5:00 PM bEVELOPMERITAL THE:RAPY Chairmen: Frank M. Schabel. Jr., Ph.D. Birmingham. AL C. Gordon Zubrod. M.D. Miami, FL APPLICATIONS OF THE HUMAN TUMOR STEM CELL ASSAY IN THE DEVELOPMENT OF ANTICANCER THERAPY Sydney E. Salmon, M.D. Tucson, AZ DRUG STUDIES IN XENOGRAFTS OF HUMAN SOLID TUMORS Awatar Krishan. Ph.D. Miami. FL ACQUIRED RESISTANCE TO THERAPEUTIC AGENTS Robert W. Brockman. Ph.D. g!rmingham, AL COFFEE BREAK RATIONALE FOFt CONGENER SY16'TH€5IS John A. Montgomery Ph.D. Birmingham. AL CONTROL OF METASTASES BY MACROPHAGES ACTIVATED WITH AGENTS ENCAPSULATED WITHIN LIPOSOMES Isaiah J. Fidler, Ph.D., D.V.M. Frederick. MD 2z _ ®1Z N 5 230 - 23

TUESDAY, SEPTEMBER 16 SYMPOSIU M 11-Oval Room Lobby Level Roosevelt Hotel 2:00-5:00 PM PHARMACOLOGY Chairman: Emil Frei. III, M.D. Boston, MA MODULATION OF ANTINEOPLASTIC THERAPY BY NUCLEOSIDES AND BY DRUG II•iTERACTIONS Bruce A. Chabner, M.D. Bethesda, MD PHARMACOLOGIC IMPLEMENT4TION OF CELL DIFFERENTIATION: MECHANISMS AND ROLE IN CANCER THERAP1f Gerald C. Mueller, M.D., Ph.D. Madison. WI BIOLOGICAL RESPONSE MODIFIERS Ennco Which, M.D. Buffalo. NY COFFEE BREAK PHARMACOLOGY OF NEW CANCER CHEMOTHERAPY AGENTS Ti Li Loo. Ph.D. Houston, TX PRE-CLINICAL TOXICOLOGY AND PHASE I Frederick S. Phi6ps. Ph.D New York, NY Charles W Young, M.D. New York, NY 2a - 4 I l TUESDAY, SEPTEMBER 16 SYMPOSIUM 12-Empire State Ballroom B Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM PEDIATRIC TUMORS Cha rman: Denman Hammond, M.D. Los Angeles, CA WILMS' TUMOR Giulio J. D'Angio, M.D. Philadelphia, PA RHABDOMYOSARCOMA Harold M. Maurer. M.D. Richmond, VA BONE TUMORS Gerald Rose,n, M.D. New York. NY COFFEE BREAK NON-HODGKIN'S LYMPHOMA Stuart E Siega!, M.D. Los Angeles. CA NEUROBLASTOMA Alvin M. Mauer. M.D. Memphis TN 523t - 25 I

TUESDAY, SEPTEMBER 16 SYMPOSIUM 13-Empire State Ballroom O F'rfth Floor Grand Hyatt Hotel 2:00-5:00 PM LEUKEMIAS Chairmen: Jean Bernard. M.D. Pans, France Joseph H. Burchenal, M.D. New York, NY TREATMENT OF GRANULOCYTIC LEUKEMIA Jean Bemard. M.D. Paris. France PROGNOSTIC FACTORS IN ADULT ACUTE LEUKEMIA Emil Freireich, M.D. Houston. TX ACUTE LYMPHOBLASTIC LEUKEMIAS Bayard D. Clarkson. M.D. New York, NY COFFEE AREAK PEDIA Tn-iC LEUKEMIAS Denis R Mtller, M.D. New York, NY CHRONIC MYELOGENOUS LEUKEMIA George P Canellos. M.D. Boston, MA r 4 TUESDAY, SEPTEMBER 16 SYMPOSIUM 14-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel- 2:00•5:00 PM SOLID TUMOR SESSION I Chairman: Gianni Bonadonrw, M.D. Milan. Italy CHEMOTHERAPY FOR ADVANCED BREAST CANCER Irwin H. Krakoff, M.D. Burlington, VL CHEMOTHERAPY IN OVARIAN CARCINOMA Robert C. Young, M.D. Bethesda. MD COMBINED MODALITY APPROACH FOR BRAIN TUMORS , William R. Sh;apiro, M.D. New York, NY COFFEE BREAK MANAGEMENT OF LOCAL AND REGIONAL MELANOMA Umberto Veronesi, M.D. Milan, Italy CHEMOTHERAPY OF ADULT SOFT TISSUE SARCOMAS H. Pinedo, M.D., Amsterdam, the Netherlands - ZT 25 1JN 5232 -

WEDNESDAY, SEPTEMBER 17 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presidirig: Saul 9 Gusberg. M.D. New York, NY Jerome J. DeCosse, M.D. New York, NY 8:30AM LYMPHOMA OVERVIEW Saul A. Rosenberg. M.D. Stanford. CA 9:15 AM GERM CELL TUMORS Robert B. Golbey. M.O. New York, NY 10:00 AM COFFtE BREAK 10:30 AM, ADVANCES IN CHEMOTHERAPY OF OTHER SOLID TUMORS James F. Holland. M.D. New York. NY 11:15 AM DEVELOPMENT OF COORDINATION CANCER CHEMOTHERAPY IN EUROPE Nenri J. Tagnon, M.D. Erussels, Betgium 11:45 AM INTEIkPRETATIOM OF CANCER CHEMOTEiERAPY, DATA Stephen K. Carter. M.D. Palo Afto. CA 12:16 PM BONE MARROW TRANSPLANTATION E. DQnnall Thomas, M.D. Seattle. WA 1:00,PM cuWH 5233 -29

WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 15-Empire State Ballroom B Fifth Fioor Grand Hyatt Hotel 2:00-5:00 PM LYMPHOMAS Chairman: Sewul A. Rosenberg, M.CI. Sto3nford. CA CHANGING CONCEPTS AND C¢A,SSIFICti4TION OF THE LYMPHOMAS-A COMMON LANGUAGE Costaq, W. Berard, M.D. Memphis, TN CHEMOTHERAPY OF LYMPHOMAS Stephen E. Jones, M.D. Tucson; AZ RADIOTHERAPY OF LYMPHOMAS Henry S. Kapl3n, M.D. Stanford. CA Ct7FFEE BREAK COMPLICATIONS OF LYMPHOMA THERAPY Arvrnrd Ghcksma3n, M.D. Providence. RI LthMPHOMd4 IN CHILDHOOD Norma,Wollner, M.D. New York, NY t 0 i WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 16-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM SOLID TUMOR SESSION !I Chairmen: Robert B. Golbey, M.D. New York. NY James F. Holland. M.D. New York, NY GU TUMORS Alan S. Yagoda, M.D. New York, NY GI TUMORS Pnilip S. Schein, M.D. Washington, DC LUNG TUMORS A. Philippe Chahinian, M.D. New York, NY COFFEE BREAK HEAD AND NECK TUMORS Robert Wttes, M.D. New York, NY GYNECOLOGICAL TUMORS OTHER THAN OVARIAN Carmef Cohen, M.D. New York, NY 5234 - 31

F_ WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 17-Empire State Ballroom D Fifth Floor Grand Hyratt Hotel 2:00-5:00 PM BONE MARROW TRANSPLANTATION Chairman: E. Donnall Thomas, M.D. Seattle. WA IMMUNE iaECONSTITUTION. GRAFT- VERSUS-HOST DISEASE, AND TOLERANCE IN ALLOGtNEIC MAP.ROW CHIMERAS Rainer Storb, M.D. Seattle. WA THE USE OF SEPARATED ALLOGENEIC HEMATOPOIETIC PRECURSORS ORS TO CIRCUMVENT GRAFT VS HOST DISEASE FOLLOWING MARROW TRANSPLANTATION Richard J. O'Reilly. M.D. Naw Yoru, NY MODIFICATION OF THE G!/'H REACTION AND CONTROL OF LEUKEMIA BY MONOCLONAL !,' NTIgODlES John A Hanser•., M.D. Seattle. WA COFFEE BREAK THE CURRENT STATUS OF AUTOLOGOUS MARROW TRANSPLANTATION George W. Santos, M.D. Baltimore, MD HISTOCOMPATIBILITY REQUIREMENTS FOR ALLOGENEIC BONE MARROW TRANSPLANTATION Bo Duwnt, M.D.. D.Sc. New York, NY 32 - WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 18-Oval Room Lobby Level Roosevelt Hotel 2:00-5:00 PM ADVANCES IN SUPPORTIVE MEASURES Chairman: Paul SherloCk, M.D. I New York, NY INFECTION PROPHYLAXIS IN CANCER THERAPY Gerald P Bodey. M.D Houston, TX NUTRITIONAL SUPPORT Maunce E. Shils, M.D., Sc.D. New York. NY PSYCHOLOGICAL SUPPORT Jimfn e Holland, M.D. New York, NY COFFEE BREAK CONTROL OF PAIN Kathleen M. Foley, M.D. New York, NY CRITICAL CARE UNIT Graziano Carlon. M.D. New 13rk, NY ®ZV 5235 -33

SYMPOSIUM 19-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM t t CANCER CONTROL Chairman: R. Lee Clark. M.D. Houston, TX THE HOSPITAL CANCER PROGRAM AND CANCER CONTROL Robert McKenna, M.D. Los Angeles. CA FOUR YEARS EXPERIENCE WITH A COMMUNITY BASED CANCER CONTROL PROGRAM HEADQUARTERED AT A COMPREHENSIVE CANCER CENTER Michael J. Brennan, M.D. Detroit. Mr WHAT IS CANCER CONTROL? Jow.,:h Parnter. M.D. Houston, TX COFFEE BREAK VALUE OF A COMMUNICATIONS OFFICE AT A COMPREHENSIVE CANCER CENTER Miriam Adams. B.A New York. NY VALUE OF AN OUT-REACH PROGRAM AT A COMPREHENSIVE CANCER CENTER Guy F. Robbins. M.D. New York, NY A NATIONAL PLANNING PROGRAM FOR CANCER REHABILITATION Larry Burke. M.S.W. Bethesda. MD 34- f ®1h NOTES 5236 - 35

THURSDAY, SEPTEMBER i8 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Arthur 1. Hofleb, M.D. New York, NY 8:30 AM PROGRESS IN CANCER SURGE6iY Edward J. Beattie, Jr., M.D. New Yc*, NY 9:15 AM PROGRESS IN RADIATION THERAPY Henry S Kaplan. M.D. Stanford, CA 10:00 AM PRpS=RESS IN CHEMOTHERAPY Vincent T DeVita, Jr., M.D. Bethesds. MD i0:d5 AM COFFEE BREAK 11:15 AM PROMISING AREAS OF CANCER RESEARCH Robert A Good, M.D.. Ph.D New York. NY 12:00 PM IMPACT OF THE NATIONAL CANCER PROGRAM R. Lee Clark, M.D. Houston, TX 12:30 PM ROLE OF GOVERNMENT IN CANCER RESEARCH The Honorable Paul C. Rogers Washington, DC 1:00 PM RELATIONSHIP OF THIS CONFERENCE TO THE AGING GONFERENCE FOLLOWING IT IN WASHINGTON Lewis Thomas, M.D. New York, NY 36 - I l NOTES ®Zh 5237 - 37