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09111,111111 ~t1e National CaiicerYnsti.ti.itc'.an the A'.mencan Cancer Society pcerEnted b}'.. ' emo~ial S1oan=Ketteriri~ • ` : - ~.Cancer.Center :. .

HOTELS GRAND HYATT HOTEL (HEADQUARTERS) Park Avenue at Grand Central New York. NY 10017 (212) 883-1234 THE ROOSEVELT HOTEL Madison Avenue at 45th Street New York, NY 10017 " (212) 661-9600 THE BILTMORE HOTEL Madison Avenue at 43rd Street New York, NY 10017 (212) 687-7000 REGISTRATION Foyer outside Empire State Ballroom, F•rftA Floor, Grand Hyatt Hotol Admission to Sessions, Exhibits and Coffee Lounges by Badge only. Registratian Hours: Seturdav. September 13.......... .1:00 p.m. to 8:00 p.m. Sunday, September 14 .............7:00 a.m. to 5:00 p.m. Monday, September 15............ 7:30 a.m. to 5:00 p.m. Tuesday, September 16............7:30 s.m. to 5:00 p.m. Wednesday. September 17...... 7:30 a.m. to 5:00 p.m. Thursday. September 18........... 7:30 a.m. to 1:00 p.m. EXHIBIT HOURS Sundat, September 14 ..... ....... 8:00 e.m. to 4:00 p.m. Monday, September 15............ 8:00 a.m. to 4:0!0 p.m. Tuesday. September 16............ 8:00 e.m. to 4:00 p.m. Wednesdey, September 17......8:00 a,m. to 5:0n p.m. Exhibits are lo;:ated on the Fifth Floor. Grand Hyatt Hotel. For exhibit descdptions, please see Pages 38 to46. .. :t..~ .~ -U 1-":".S~p`0W'j~' ''' i',ir'r:"•_' J i ZN 5219 -1

SYMPOSIUM OFFICE The Symposium, office in the Uns Room on the Fourth Floor in the Grand Hyatt Hotel will be open after 1:00 p.m. on Saturday, Septem4er 13, and will remain open during regostration hours through Thursday, Sep- tember 18. Symposium Office Director: Mrs. M. Virginia Herhtz SPEAKERS'NEADQUARTERS The Speakers' Headquarters are located in the Alvin Room, Fourth Floor, Grand Hyatt Hotel. AII program palticipants shohld report to the Alvin Room to receive their badge and other pertinent material. Speakers' Room Director: Ms. Leslie M. Anton INFORMATION AND MESSAGE CENTER The Information and Message Center will be located in the Registration Area. Registration cards of all participants are filed in the Visible Directory located in the Registration Area. Registrants shoWd check daily for telephone mes- sages, notes and mail. PRESS ROOM The Press Room is located in the Broadway Room on the Fourth Floor of the Grand Hyatt Hotel. Members of the Press should report to the Broadway Room to receive the official press badge. Interview facilities wfll be provided. Saturday ...................................1:00 p.m. to 5:00 p.m. Sunday through rlVednesday...8:00 a.m. to 5:30 p.m. Thursday ............ :...................... B:00 a.m. to 2:30 p.m. Press Room Director: Ms. Patricia Mohno 2- LOST AND FOUND Inquiries concerning lost articles should be made at the Symposium Headquarters Office. Articles found should be delivered to the Symposium Office. Slides left in session rooms will be delivered herc by projec- tion operators. REQUEST FOR °NO SMOXING- It is requested that all registrants refrain from smoking in the meeting rooms and exhibit area. COMTINUING MEDICAL EDUCATION As arw organiiation accredited for Continuing Medical Education, Memorial Sloan-Kettering Cancer Center designates this Continuing Medical Education activity as meeting the criteria for 34 credit hours in Cate- gory I of the Physician's Recognition Award of the American Medical Association. Registrants who meet the requirements for partici- pation, in this continuing educational orogram will re- ceive a statement of certification of participation fol- towinp, the meeting. Announcementsof the procedures will be made at each session during the progrr3m. A Continuing Medical Education booth will be located in the Reglistration Area. AUDIO TRANSCRIP:'S All scietrtific sessions will be instantly transcribed and available Yor purchase on site. The Audio Transcripts desk will be located in the Registration Area, Fifth Ftoor, Grand Hyatt Hotel. HOSPITALITY DESK The Hospitality Desk will be rocated in the Registration _Area 5220 - 3

1980 Inteinational Symposium on Cancer General Chairman: Edward J. Beattie, Jr., M.D General Director & Chief Medical Officer, Memorial Hospital Memoria; Sloan-Kettering Cancer Center New York, NY Vice Chairnian: William 5. F9owland, M.D. Vice President for Clinical Affairs Memorial Sloan-Kettering Cancer Center New York. NY Advisory Committee: Laurdnce S. Rockefeller Chairman of, the Board Memorial Sloan-Kettenng Cancer Center Benno C. Schmidt 03irman of the Board Memorial Hospital Fred Seitz, Ph D. Chairman of the Board Sloan-Kettering Institute James D. Rmbinson, Ili Vice Chairman of the Board Memorial Hospital Lewis Thomas. M.D. Chancellor, Memorial Sloan-Kettering Cancer Center Robert A. Good. Ph.D.. M.D. Vice President Memorial Sloan-Kettering Cancer Center Lane W Addms Executive Vice President American Cancer Society Arthur I. Holleb. M.D. Senior Vice aresident for Medical Affairs American Cancer Society

Frank J. Rauscher, Jr., Ph.D. Senior Vice President for Research American Cancer Society Vincent T. DeVita. Jr., M.D. Drrector, National Cancer Institute PROGRAM COMMITTEE Chairman: Joseph H. Burchenal. M.D. Director, Clinical Investigation Memorial Sloan-Kettering Cancer Center New York, NY Members; Bayard D. Clarkson. M.D. Chief. HematologY/Lymphoma Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York. NY Jerome J. DeCosse. M.n. Chairman. Department of Surgery Memorial Sloan-Kettering Cancer Center New York. NY Vincent T DeVita. Jr.. M.D. Director, National Cancer Institute National Institutes of Health Bethesda, MD William S. Howland. M.D. Vice President for Clinical Affairs Memorial Sloan-Kettering Cancer Center New York, NY Mathilde Krim, Ph.D. Associate Member, Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center New York. NY LaSalle D. Leffall, Jr., M.D. Immediate Past President, American Cancer Society Professor & Chairman, Department of Surgery Howard University CMlege of Medicine VVashington, DC s_ a ;.zP ;~.,i~ Damel G. Miller. M.D. . Director. Preventive Medicine Institute Strang Clinic New York, NY Denis R. Miller, M.D. Chairrutan, Department of Pediatrics Memoria/ Sloan-Ket'tenng Cancer Center New ti'ork. NY Herbert F Oettgen, M.D. Chief, Clwnical Immpnotogy Service Department of Medicme Memorial Sloan-Kettering Cancer Center New York. NY Lloyd J. K)Id, M.D. Vice President & Assopiate Director for Scientific Development Sloan-Kettering Institute Memoriat Sloan-Kettering Cancer Center New York, NY Richard J. O'Reilly, M.D. Director, Bone Marrow Transplantation Program Memorial Sloan-Ketkedng Cancer Center New York. NY Frank J. Rauscher, Jr., Ph.D. Senior Vpce President for Research American Cancer Societiy, Inc. New York, NY William R. Shapiro. M.D. Anending Neurologist Memorial Sloan-Kettering Cencer Center New York, NY Paul Sherlock, M.D. Cnarrman. Department of Medicine Memorial Sloan-Kettering Cancer Center New York. NY Charles 1N. Young, M.D; Chief, Developmental Chemotherapy Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York, NY Ex Officio: t Edward J. BeatGe. Jr.. EUI.D. General Director & ChiO Medical Officer. Memorial Hospital Memorial Sloan•Ktmering Cancer Center New York, NY ®lN1 5222 ..: -7

Robert A. Good, Ph.D., M.D. Vice President, Memonal Sloan•Kettering Cancer Center New York, NY SYMPOSIUM STAFF Program Coordinator: Ms. Leslie M. Anton Registrar: Mrs. M. Virginia Herhtz Meetmg and Exhibit Management: Sceven K. Herhtz, Inc. CANCER INFORMAT10N SERVICES Ly+4IBIT Registration Area Cancer research scientists and clinicians are encour- aged to visit a display oi the cancer information serv ces available through the Internatiqnal Cancer Research Data Bank (ICRDB) Program of the National Cancer Institute. These services include computer data bases deaNng with CANCER LITerature, (the CANCERLIT data base), and summaries of CLINICAL PROTocols (the CLINPROT data base). In addition to the three data bases (collectively called CANCERLINE), the ICRDB Program disseminates 65 monthly current awareness bulletins caIled CANCERGRAMS. each containing about 25-100 abstracts in different major areas of cancer re- search. A COMPILATION OF CANCER THERAPY PRO- TOCOL SUMMARIES is also published annually. e- ...Si'°.. SURIDAY, SEPTEMBER 14 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Lewis Thomas, M.D. New York, NY Joseph H. Burchenal. M.D. New York. NY B:30 AM AIMS OF THE CONFERENCE eeino C. Schmidt New York, NY 6:50 AM PURPOSES OF THE NATIONAL CANCER ACT Frank J. Rauscher, Jr., Ph.D. New York, NY 9:15 AM EPIDEMIOLOGY FOR CLUES TO ETICILOGY John Higginson, M.D. Lyon. France 10:00 AM VIRUSES AND CANCER George Klein, M.D., D.Sc. Stockholm. Sweden 10:45 AM COFFEE BREAK 11:15 AM RADIATION HAZARDS Arthur C. Upton, M.D. New York. NY 12:00 PM INDUSTRIAL AND LIFE-STYLE CARCINOGENS Michael B. Shimkin, M.D. Le Jolla, Ca 12:45 PM Ll/NCH I Z NI 5223 -9 : ..... :;i~. i

SYMPOSIUM 1-Empire State Ballroom C Fifth Floor Grand Hyatt Hotet 2:00-5:00 PM EPIDEMIOLOGY Chairman, John Higgmson, M.D. Lyon, France AN'ALYTIC EPIDEMIOLOGY Philip Cole, M.D., Dr. P.H. Br.mingham, AL THE INTERPHASE BETWEEN EPIDEMIOLOGY AND CANCER CONTROL POLICY Sir Richard Doll, M.D. Oxford. United Kingdom COFFEE BREAK DESCRIPTIVE EPIDEMIOLOGY AND GEOGRAPHICAL PATHOLOGY Brian E. Henderson, M.D. Los Angeles. CA LIFESTYLE FACTORS IN HUMAN CANCER Anthony B. Miller, M.B. Toronto, Canada SUNDAY, SEPTEMBER 14 SYMPOSIUM 2-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM VIRUSES Chairman: George Klein, M.D., D.Sc. Stockholm. Sweden TRANSFORMATION BY SMALL DNA VIRUSES Thomas L. Benjamin. Ph.D. Boston. MA MECHANISM OF TRANSFORMATION BY AVIAN AND MURINE RNA TUMOR VIRUSES Peter Duesberg. Ph.D. Berkeley, CA FELINE LEUKEMIA AND SARCOMA VIRUSES Myron Essex, D.V.M., Ph.D. Boston. MA COFFEE BREAK EBV: ITS RELATION TO BURKITTS LYMPHOMA AND NASOPHARYNGEAL CARCINOMA Gertrude Henle, M.D. Philadelphia, PA V1~emer Henle, M.D. Philadelphia. PA HEPATlTIS B-VIIRUS1AND HEPATOMA Baruch S. Blumberg. M.D.. Ph.D. Philadelphia, PA I z M 5224 _1,

SYMPUSIUM 4-Empire State Ballroom D Fifth FIcWr Grand Hyatt Hotel 2:D0•5:00 pM INDUSTRIAL AND LAFE.•S7YLE CARCINOGENS Chairman: Michael B. Shimkin, M.D. La Jolla, CA METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS Elizabeth C. Miner, Ph.D. Madison. WI DETECTIION OF CARCINOGENS Jeffrey C. Theiss. Ph.D. Houston, TX EPIDEMiOLOCIC EVIDENCE Irving J. Selikoff. M.D. New York, NY COFF-te BREAK THE ROLE OF POPULATION-BASED TUMOR REGISTRIES IN IDENTIFYING OCCUPATIONAL CARCINOGENS Donald F. Austin. M.D. Oakland. CA PU@LIlr'POLICY LEGISLATION David Rall, M.D., Ph.D. Research Triangle Park, NC I b

Rf~ONDAY, SEPTEMBER 15 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Frank J. Rauscher. Jr.. Ph.D. New York, NY Paul Marks, M.D. New York, NY 8:30 AM ' HrJST DEFENSE AGAINST CANCER Herbert F. Oettgen, M.D. New York. NY 9:;15 AM GENETICS AND CANCER Aitred G. Knudson, Jr.. M.D., Ph.D. Philadelphia, PA 10:00 AM COFFEE BREAK 1 fd,:30 AM CELL BIOLOGY AND CANCER John Caims, M.D., Ph.D. London. England 11:15AM PREVENTION OF CARCINOGENESIS Lee W. Wattenberg, M.D. Minneapolis, MN 12,:00 PM LOCALIZED DISEASE-THE CURE WITHIN OUR GRASP Daniel G. Miller, M.D. New York, NY 12;45 PM LUNCH ®1 N 1 55226 _,s

SYMPOSIUM 6-Oval Room Lobby Level Roosevelt Hotel 2:00•5:00 PM GENETICS Chairman: Alfred G. Knudson, Jr., M.D . Ph D Philadedphia, PA THE GENETIC EPIDEMIOLOGY OF HUMAN CANCER: BREAST CANCER AS AN EXAMPLE M7ry•Claire King, Ph.D. Berkeley. CA SPECIFIC FINE STRUCTURAL CHROMOSOME DEFECTS IN HUMAN NEOPLASIA Jorge J. Yunis. M.D., Ph.D Minneapolis, MN COFFEE BREAK CLINICAL FEATURES OF GENETIC CANCER Fredenck P Li. M.D. Boston, MA CHROMOSOME 1411N BENIGN AND MAdi GNANT LYMPHOID CANCER Frederick Hecht, M.D. Tempe. AZ ON 5227 -17

ftflONDAY, SEPTEMBER IS SYMPOSIUM 7-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM CELL BIOLOGY AND CANCER Chairman: John Carrns, M.D., Ph.D. London, United Kingdom EVOLUTION OF THE MALIGNANT PHENOTYPE IN AN EPITHELIAL CANCER AS SEEN IN THE CASE OF MOUSE MAMMARY Daniel Medina. Ph.D. Houston, TX SUPPRESSION OF MYELOID LEUKEMIC CELLS BY BIOLOGICAL REGULATORS Donald Metcati, M.D. Melbourne. Australia CELLULAR AND HOST ASPECTS OF TUMOR METASTASIS Garth L. Nitolson, Ph.D. Houston, TX HIGH EFFICIENCY, KINETICS AND NUMEROLOGY OF TRANSFORMATION BY RADIATION 1N VITRO Ann R. Kennedy. S.D. Boston, MA STATUS OF STUDIES ON THE EXACT PHENOTYPE OF CANCER CELLS Robert Poilack, Ph.D. New York, NY te- MONDAY SEPTEMBER 15 SYMPOSIUM 8-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM PREVENTION OF CARCINOGENESIS Charrman: Lee W. Wattenberg, M.D. Minneapolis, MN CHEMOPREVENTION OF NEOPLASIA WITH RETINOIDS Michael B. Spom, M.D. Bethesda, MD BLOCKING OF TUMOR PROMOTION BY PROTEA$E INHIBITORS Walter Troll, Ph.D New York. NY INHIBITION OF FORMATION OF CARCINOGENIC NITROSAMINES AND NITROSAMIDES Sidney Mnvish, Ph.D. Orrraha, NB COAFE'€ BREAK REDUCTION IN THE FORMATION OF MUTAGENS AND CARCINOGENS IN THE LARGE BOWEL OF MAN W. Robert Bruce, M.D.. Ph.D. Toronto, Canada DIETARY, FACTORS IN THE CAUSATION AND PREVENTION OF NEOPLASIA John Weisburger. Ph.D. Valhalla, NY 5228 -t9

RAOIiIOAY, SEPTEMBER 15 SYMPOSIUM 9-Empire State Ballroom B Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM ADVANCES IN DIAGNOSIS Chadrmen: Daniel 6. Miller, M.D. New York. NY Sidney J. Wmawer, M.D. New York, NY BIOCHEMICAL AND IMMUNOLOGIC DIAGNOSIS OF CANCER Morton K. Schwartz, Ph.D. New York, NY NUCLEAR IMAGING IN CANCER DIAGNOSIS Henry N. Wagner, Jr.. M.D. Baltrmore, MD RADIOLOGIC ADVANCES IN CANCER DIAGNOSIS Michael Deck. M.D. Nsw York. NY COFFEE MEAK EARLY DIAGNOSiS OF LIVER CANCER AND ITS PRECEDING STAGE THROUGH AFP SEROLOGY Sun Tsung•Tang. M.D. 6eq!ng. People's Republic of China CYTOLOGIC ADVANCES IN - CANCER CONTROL Myron R. Melemed. M.D. New York, NY ADVANCES IN DIAGNOSIS OF GASTROINTESTINAL NEOPLASMS H. Worth Boyce. Jr., M.D. Tampa. FL I RIOTES 5229 . .. . ~ -u~. .__. -21 I

TUESDAY, SEPTEMBER 16 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Vincent T. DeVita. Jr.. M.D. Bethesda, MD C Chester Stock. Ph.D. New York. NY 8:30 AM DEVELOPMENT OF,ANTICANCER THERAPY C. GordonZubrod, M.D Miami, FL 9:10 AM Li4BORATORY METHODS FOR THE DETECTION AND DEVELOPMENT OF CLINICALLY USEFUL ANTICANCER DRUGS Frank M. Schabel. Jr., Ph.D Birmingham. AL 9:50 AM PHARMACOLOGY Emil Fret. III, M.D. Boston, MA 10:30 AM COFFEE BREAK 11:0D AM PEDIATRIC OVERVIEW Denman Hammond. M.D. Los Angeles. CA 11:40 AM LEUKEMIA OVERVIEW Joseph H Burchenal, M.D. New York. NY 12:20 PM CARCINOMA OF THE BREAST Ganni Bonadonna, M.D. Mdan, Italy 1:00 PM LUNCH IUESDAY, SEPTEMBER 16 SYMPOSIUM 10-Terrac.e Room Lobby Level Roosevelt Hotel 2:00-5:00 PM bEVELOPMERITAL THE:RAPY Chairmen: Frank M. Schabel. Jr., Ph.D. Birmingham. AL C. Gordon Zubrod. M.D. Miami, FL APPLICATIONS OF THE HUMAN TUMOR STEM CELL ASSAY IN THE DEVELOPMENT OF ANTICANCER THERAPY Sydney E. Salmon, M.D. Tucson, AZ DRUG STUDIES IN XENOGRAFTS OF HUMAN SOLID TUMORS Awatar Krishan. Ph.D. Miami. FL ACQUIRED RESISTANCE TO THERAPEUTIC AGENTS Robert W. Brockman. Ph.D. g!rmingham, AL COFFEE BREAK RATIONALE FOFt CONGENER SY16'TH€5IS John A. Montgomery Ph.D. Birmingham. AL CONTROL OF METASTASES BY MACROPHAGES ACTIVATED WITH AGENTS ENCAPSULATED WITHIN LIPOSOMES Isaiah J. Fidler, Ph.D., D.V.M. Frederick. MD 2z _ ®1Z N 5 230 - 23

TUESDAY, SEPTEMBER 16 SYMPOSIU M 11-Oval Room Lobby Level Roosevelt Hotel 2:00-5:00 PM PHARMACOLOGY Chairman: Emil Frei. III, M.D. Boston, MA MODULATION OF ANTINEOPLASTIC THERAPY BY NUCLEOSIDES AND BY DRUG II•iTERACTIONS Bruce A. Chabner, M.D. Bethesda, MD PHARMACOLOGIC IMPLEMENT4TION OF CELL DIFFERENTIATION: MECHANISMS AND ROLE IN CANCER THERAP1f Gerald C. Mueller, M.D., Ph.D. Madison. WI BIOLOGICAL RESPONSE MODIFIERS Ennco Which, M.D. Buffalo. NY COFFEE BREAK PHARMACOLOGY OF NEW CANCER CHEMOTHERAPY AGENTS Ti Li Loo. Ph.D. Houston, TX PRE-CLINICAL TOXICOLOGY AND PHASE I Frederick S. Phi6ps. Ph.D New York, NY Charles W Young, M.D. New York, NY 2a - 4 I l TUESDAY, SEPTEMBER 16 SYMPOSIUM 12-Empire State Ballroom B Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM PEDIATRIC TUMORS Cha rman: Denman Hammond, M.D. Los Angeles, CA WILMS' TUMOR Giulio J. D'Angio, M.D. Philadelphia, PA RHABDOMYOSARCOMA Harold M. Maurer. M.D. Richmond, VA BONE TUMORS Gerald Rose,n, M.D. New York. NY COFFEE BREAK NON-HODGKIN'S LYMPHOMA Stuart E Siega!, M.D. Los Angeles. CA NEUROBLASTOMA Alvin M. Mauer. M.D. Memphis TN 523t - 25 I

TUESDAY, SEPTEMBER 16 SYMPOSIUM 13-Empire State Ballroom O F'rfth Floor Grand Hyatt Hotel 2:00-5:00 PM LEUKEMIAS Chairmen: Jean Bernard. M.D. Pans, France Joseph H. Burchenal, M.D. New York, NY TREATMENT OF GRANULOCYTIC LEUKEMIA Jean Bemard. M.D. Paris. France PROGNOSTIC FACTORS IN ADULT ACUTE LEUKEMIA Emil Freireich, M.D. Houston. TX ACUTE LYMPHOBLASTIC LEUKEMIAS Bayard D. Clarkson. M.D. New York, NY COFFEE AREAK PEDIA Tn-iC LEUKEMIAS Denis R Mtller, M.D. New York, NY CHRONIC MYELOGENOUS LEUKEMIA George P Canellos. M.D. Boston, MA r 4 TUESDAY, SEPTEMBER 16 SYMPOSIUM 14-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel- 2:00•5:00 PM SOLID TUMOR SESSION I Chairman: Gianni Bonadonrw, M.D. Milan. Italy CHEMOTHERAPY FOR ADVANCED BREAST CANCER Irwin H. Krakoff, M.D. Burlington, VL CHEMOTHERAPY IN OVARIAN CARCINOMA Robert C. Young, M.D. Bethesda. MD COMBINED MODALITY APPROACH FOR BRAIN TUMORS , William R. Sh;apiro, M.D. New York, NY COFFEE BREAK MANAGEMENT OF LOCAL AND REGIONAL MELANOMA Umberto Veronesi, M.D. Milan, Italy CHEMOTHERAPY OF ADULT SOFT TISSUE SARCOMAS H. Pinedo, M.D., Amsterdam, the Netherlands - ZT 25 1JN 5232 -

WEDNESDAY, SEPTEMBER 17 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presidirig: Saul 9 Gusberg. M.D. New York, NY Jerome J. DeCosse, M.D. New York, NY 8:30AM LYMPHOMA OVERVIEW Saul A. Rosenberg. M.D. Stanford. CA 9:15 AM GERM CELL TUMORS Robert B. Golbey. M.O. New York, NY 10:00 AM COFFtE BREAK 10:30 AM, ADVANCES IN CHEMOTHERAPY OF OTHER SOLID TUMORS James F. Holland. M.D. New York. NY 11:15 AM DEVELOPMENT OF COORDINATION CANCER CHEMOTHERAPY IN EUROPE Nenri J. Tagnon, M.D. Erussels, Betgium 11:45 AM INTEIkPRETATIOM OF CANCER CHEMOTEiERAPY, DATA Stephen K. Carter. M.D. Palo Afto. CA 12:16 PM BONE MARROW TRANSPLANTATION E. DQnnall Thomas, M.D. Seattle. WA 1:00,PM cuWH 5233 -29

WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 15-Empire State Ballroom B Fifth Fioor Grand Hyatt Hotel 2:00-5:00 PM LYMPHOMAS Chairman: Sewul A. Rosenberg, M.CI. Sto3nford. CA CHANGING CONCEPTS AND C¢A,SSIFICti4TION OF THE LYMPHOMAS-A COMMON LANGUAGE Costaq, W. Berard, M.D. Memphis, TN CHEMOTHERAPY OF LYMPHOMAS Stephen E. Jones, M.D. Tucson; AZ RADIOTHERAPY OF LYMPHOMAS Henry S. Kapl3n, M.D. Stanford. CA Ct7FFEE BREAK COMPLICATIONS OF LYMPHOMA THERAPY Arvrnrd Ghcksma3n, M.D. Providence. RI LthMPHOMd4 IN CHILDHOOD Norma,Wollner, M.D. New York, NY t 0 i WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 16-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM SOLID TUMOR SESSION !I Chairmen: Robert B. Golbey, M.D. New York. NY James F. Holland. M.D. New York, NY GU TUMORS Alan S. Yagoda, M.D. New York, NY GI TUMORS Pnilip S. Schein, M.D. Washington, DC LUNG TUMORS A. Philippe Chahinian, M.D. New York, NY COFFEE BREAK HEAD AND NECK TUMORS Robert Wttes, M.D. New York, NY GYNECOLOGICAL TUMORS OTHER THAN OVARIAN Carmef Cohen, M.D. New York, NY 5234 - 31

F_ WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 17-Empire State Ballroom D Fifth Floor Grand Hyratt Hotel 2:00-5:00 PM BONE MARROW TRANSPLANTATION Chairman: E. Donnall Thomas, M.D. Seattle. WA IMMUNE iaECONSTITUTION. GRAFT- VERSUS-HOST DISEASE, AND TOLERANCE IN ALLOGtNEIC MAP.ROW CHIMERAS Rainer Storb, M.D. Seattle. WA THE USE OF SEPARATED ALLOGENEIC HEMATOPOIETIC PRECURSORS ORS TO CIRCUMVENT GRAFT VS HOST DISEASE FOLLOWING MARROW TRANSPLANTATION Richard J. O'Reilly. M.D. Naw Yoru, NY MODIFICATION OF THE G!/'H REACTION AND CONTROL OF LEUKEMIA BY MONOCLONAL !,' NTIgODlES John A Hanser•., M.D. Seattle. WA COFFEE BREAK THE CURRENT STATUS OF AUTOLOGOUS MARROW TRANSPLANTATION George W. Santos, M.D. Baltimore, MD HISTOCOMPATIBILITY REQUIREMENTS FOR ALLOGENEIC BONE MARROW TRANSPLANTATION Bo Duwnt, M.D.. D.Sc. New York, NY 32 - WEDNESDAY, SEPTEMBER 17 SYMPOSIUM 18-Oval Room Lobby Level Roosevelt Hotel 2:00-5:00 PM ADVANCES IN SUPPORTIVE MEASURES Chairman: Paul SherloCk, M.D. I New York, NY INFECTION PROPHYLAXIS IN CANCER THERAPY Gerald P Bodey. M.D Houston, TX NUTRITIONAL SUPPORT Maunce E. Shils, M.D., Sc.D. New York. NY PSYCHOLOGICAL SUPPORT Jimfn e Holland, M.D. New York, NY COFFEE BREAK CONTROL OF PAIN Kathleen M. Foley, M.D. New York, NY CRITICAL CARE UNIT Graziano Carlon. M.D. New 13rk, NY ®ZV 5235 -33

SYMPOSIUM 19-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM t t CANCER CONTROL Chairman: R. Lee Clark. M.D. Houston, TX THE HOSPITAL CANCER PROGRAM AND CANCER CONTROL Robert McKenna, M.D. Los Angeles. CA FOUR YEARS EXPERIENCE WITH A COMMUNITY BASED CANCER CONTROL PROGRAM HEADQUARTERED AT A COMPREHENSIVE CANCER CENTER Michael J. Brennan, M.D. Detroit. Mr WHAT IS CANCER CONTROL? Jow.,:h Parnter. M.D. Houston, TX COFFEE BREAK VALUE OF A COMMUNICATIONS OFFICE AT A COMPREHENSIVE CANCER CENTER Miriam Adams. B.A New York. NY VALUE OF AN OUT-REACH PROGRAM AT A COMPREHENSIVE CANCER CENTER Guy F. Robbins. M.D. New York, NY A NATIONAL PLANNING PROGRAM FOR CANCER REHABILITATION Larry Burke. M.S.W. Bethesda. MD 34- f ®1h NOTES 5236 - 35

THURSDAY, SEPTEMBER i8 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Arthur 1. Hofleb, M.D. New York, NY 8:30 AM PROGRESS IN CANCER SURGE6iY Edward J. Beattie, Jr., M.D. New Yc*, NY 9:15 AM PROGRESS IN RADIATION THERAPY Henry S Kaplan. M.D. Stanford, CA 10:00 AM PRpS=RESS IN CHEMOTHERAPY Vincent T DeVita, Jr., M.D. Bethesds. MD i0:d5 AM COFFEE BREAK 11:15 AM PROMISING AREAS OF CANCER RESEARCH Robert A Good, M.D.. Ph.D New York. NY 12:00 PM IMPACT OF THE NATIONAL CANCER PROGRAM R. Lee Clark, M.D. Houston, TX 12:30 PM ROLE OF GOVERNMENT IN CANCER RESEARCH The Honorable Paul C. Rogers Washington, DC 1:00 PM RELATIONSHIP OF THIS CONFERENCE TO THE AGING GONFERENCE FOLLOWING IT IN WASHINGTON Lewis Thomas, M.D. New York, NY 36 - I l NOTES ®Zh 5237 - 37

I ABBOTT DIAGNOSTICS BOOT1O 10 Abbott Park-Dept. 49B North Chicago, IL 60064 312/937,9425 Scientists will be available to discuss, two new assays for CEA. Your laboratory will have a choice of easy to use RIA or EIA methodologies. Resirlts are available from either in just one day ACCURATE CHEMICAL & &CIEIoiTIF1C CORP BOOTH 21 28 Tee St. Hicksville, NY 11801 516/433-4900 They will feature Cedarlane's Mouse Immunology products; Nyegaard's Metrizamide, for separation of biological particles. Lyrnphoprep, Sodium Metrizoate for separation of red blood cells; Sera Labs- Monoclonal antisera, Alhydrogel and Clwl-A adjuvant, Antibodies. ADRIA LABORATORIES IN!0C. BOOTH 9 P.O. Box 16529 Columbus, OH 43216 6141764-0119 Adrucil• Fluorouracil, USP, is a florinated pyrimidine belonging to the category of antimetabolites. Adrucil is effective in the palliative management of carcinoma of the colon, rectum, breast. stomach, and pancreas in patients who are considered ihcurable by surgery or Adriamycin'. doxorubicin HC1 for injection, and An- thracycline antibiotic, has demonstrated a wide range of activity in both solid and liquid malignancies. Among the neoplasms showing response are: Breast carci- noma of the lung, ovarian carcinoma, non-Hodgkins lymphoma, acute myelogenous and acute lymphocytic leukemia. Due to the dose limiting taxicities, myelo- suppression and cardio-toxicity, Adriamycin should be administered under the supervision of a trained spe- cialist. Additanally, the total accumutative dose should be limited to 550 mglMr. 3e- t ~ AL1A CObiPORATION BOOTHS 13,14 950 Page Mill Rd. Palo AItoK CA 94304 415/494-5575 The Alzets osmotic minipump delivers solutions con• tinuoUsly at 1 µt/hr., 7 days and .5 µ1/hr, '14 days in animals as Emall as mice, without the need for externai connections or frequent handling of the animals. These implantable pumps have been successfully used in experimental studies of the effects of continuous administration of cancer chemotherapeutic agents, addictbve dru®s, hormones, and antigens. The Alzett osmotic rninipumps are a one-time use device. During their functional Iifetime, the Alzets osmotic min pump acts as a constant source of drug within an animal's body. BECTON DICKINSON LABWARE BOOTH 28 140 Barrl®y Ctr. Cherryr Mill,, NJ 08034 609/429-7590 Manufactures the Falcon line of plastic disposable lab- ware and the Gold Seal line of glass disposable prod• ucts for the laboratory. Falcon products include petri dishes, tubes; pipets, roiler bottles, flasks, microtest dishes and filters with key emphasis in the Tissue Cul- ture area. The Gold Seal product line of glass disposable products inclddes slides, oover glass, micropets and pipetting guns. 1 BEECHAM LABORATORIES BOOTH 6 501 Fitth St: Bristos, TN 37620 615/764-5141 Ticare is a serrii-synthetic pen'.~illin that is indicated for hospitalized patients with senous infections. Tigant is a non•phenothiazine antiemetio-anti-rnauseate. BRISTOL L+41'.ORATORIES BOOTH 29 P.O. Box 657 . Syracrose, NY 13201 315/432 2799 They will feature the Anti-Cancer Product Line. Rep- resentatives welcome the opportunity to answer your questions concerning their entire product line. ItN ` 5238 -39 I

CORMED, INC. BOOTH 31 3 North Main St. Middleport, NY 14105 716/735•7957 1 They will exhibit an Ambulatory Infusion Pump for Can• cer Chemotherapy as well as an Ambulatory Hyper- alimentation System. Both Systems may be carned by the pat ent. COULTER ELECTRONICS, INC. BOOTH 26 601 West 20th Hiateah, FL 33010 30505-0131 ELSEVIER NORTH HOLLAND, INC. I EXCERPTA MEDICA BOOTH 30 52 Vanderbift Ave. New York, NY 10017 212/867•8040 They publish medical and scientific books and journals which indude: Cancer Chemotherapy Handbook by ;.3rr/Fritz, the Chromosomes in Human Cancer and Leukemia by Sandberg. Cancer Chemotherapy Annual 1-1979 by Pmedo. Progress in Myeloma by Potter. Compendium of Assays for i*"munodiagnosis of Hu• man Cancer by Herberman. Medical Oncology by Lessner. Cancer Genetics and Cytogenetres, Cancer Letters, Onco-developmental Biology and Medicine. ENDO LABORATORIES, INC. BOOTH 8 1000 Stewart Ave. Garden City. NY 11530 616/832,2022 They will feature Nubains, nalbuphine HC1, a^d Per- codane oxycodone HC1, oxycodone terephthatate and aspirin. Full prescribing information on these and on their other products sre available. GRUNE & STiiATTON, INC. BOOTH 17 ACADEMIC PRESS. INC. 111 FNth Ave. New York, NY 10003 2121741-6658 40- , I They will present: Brodsky: Cancer Chemotheiapy Ill. Clark: Human Malignant Melanoma; Gunz: Leukem a, Jones/Salmon: Adjuvant Therapy of Cancer II; and the journal: Seminars in Oncology. Academic Press pre- sents: Advances in Cancer Research, Vols. 31, 32; Coulstow Regulatory Aspects of Carcinogenesis And Food Additives: The Delaney Clause; Gresse'r: Inter- feron 1979; Hetberman: Natural Ceu-Mediazed Im- munity Against Tumors; and Pick: Lymphokine Re- ports. Vols. 1, 2. IVES LABORATORIES INC. BOOTH 32 685 Third Ave. New York, NY 10017 2121878-3107 They will be featuring their new antineoplastic agent, Cerubidmes, daunorubipn, for the treatment of leu- kemia. Representatives will be ready to discuss Cer- ubidinei and their other products with you- JANSSEN PHARMACEUTICA. INC. BOOTH 15 501 George St. New Brunswick, NJ 08903 201 /524•l898 Monistat iv. is _~ridicated for the treatment of the fot- fovving severe sWwmrc fu :bal infections: coccid1o1- domycosis, candididsis. cryptococcosis, paracoccidioi- domycosis. and for the treatment of chronic mucocutaneouscandidrasis. However, inthe treatment of fungal meningitis and urinary bladder infections an intravenous infusion alone is inadequate. It must be supplemented with intrathecal administration and blad- der irrigation. Dosage: Adults The doses may vary with the diagnosis and with the infective agent, from 2D0 to 1200mg per infusion. Monistat i.v miconezole, is an original product of Janssen Pharmaceutica N.V., Belgium. JENA SCIENTIFIC INSTRUMENTS, INC. BOOTH 24 1211 Avenue of the Atnterioas Room 450 New York, NY 10036 Z12(844J660 They will display graphics depicting the Parmoquant 2, en automaac measuring microscope for particle elec- I Z`~ a1

trophoresis. Also available will be literature and sci- entific articles describing the usefulness of the Par- moquant 2. KAY ~,AB!]!RATORIFS, INC. ~OOTH 33 PO. Sox 01571 San Diego; CA 92138 7141297-5070 The Kold Kap' Scalp Hypothermia Patie~t Aid offers chemotherdpy patients safe, instant, comfortabte, con- trolled applrcation of cold therapy for the scalp. Scalp hypothermia has been proven effective in the preven- tion of heir loss among patients receiving r,oxorubicin, adriamycin, on every three week, moderaSe, less than 50mg, dose regimen. The Kay Kold Kap°' elrmuiates the need fob ice handling or product refng'eratron. KNOLL PkARMACEUTifrAL CO. BOOTH 16 30 No. Jeftbrson Rd. Whippany,, NJ 07981 201/887-8300 Vicodma is 0, Schedule III narcotic analgesic formufa containing hyroaxfone 5 mgi with acetaminophen 500 mg• Vicodin is indicated for the relief of moderate to moderately severe pain associated with : irgery, ep- isiotomy, acdte trauma, musculoskeletal o.sorders end oral surgery.,Vrcodm is administered orally. D"naudidE, hydromorphcne hydrochlonde, a hydrogenated ketone of morphine, qs available for oral, parenteral and rectal administration. Dilaudid is indicated for the relief of moderate to severe pain due to: surgery, cancer, trauma, soft tissue and bone. biliary colic, myocardial infarction, burhs and renal colic. Dilaudid is a Schedule 11 narcotic analgesic. KORMED BOOTH 1A 2510 Northland Dr. St. Paul, MN 55120 812/452-5550 Manufacturer of Jamshidi Bone Marrow Biopsy/Aspi- raticn Needles and Bone Marrow needle, disposable and replaceable cannuta; modified disposable Mengh- ini needle; disposable modified University of Illinois Needle; disposable cytology aspiration biopsy tray and mini kit; muscle biopsy devrce; pleuraVsynowat biopsy device. 42 LAB PRODUCTS, INC. BOOTH 19 365 W. Possaic St. Rochelle Park, NJ 07662 201/5434800 Plastic rodent cages. Iso-cage System, Disposable cages and See-Through suspended rodent cage sys- tem; Stay Clean tsmmar flow rack, metal cages, Atr Sorb-Dn hardwood laboratory animal beddmg, auto- matic watering systems and polycarbonate water bot- tles. LEA & FEBIGER BOOTH 20 600 S. Washington Square Philadelphia, PA 19106 2151922-1330 Featured: Hajdu-Pathology of Soft Tissue Tumors; Cooper & Pixzarello-Concepts in Cancer C:are: A Prac- tical Explanation of Radiotherapy and Chemotherapy for Primary Care Physicians; Cassileth-Ths Cancer Pa- tient; Helm-Cancer pennatology; Theilen & Madewen- Veterinary Cancer Medicine; Fletcher-Textbook of Ra- diotherapy. 3rd ed.; McCarthy & Shklar-Diseases of the Oral Mucosa, 2nd ed. See prepubtication material for. Holland & Frei-Cancer Medicine, 2nd ad.: Wintrobe etal: Clinicat Hematology. 8th ed. E. LERZ, INC. BOOTHS 3,4 Link Dr. Rockleigh, NJ 07647 201/767-1100 Wdl be exhibiting the new Labodux 11 and Labortux 12 laboratory microscopes. In conjunction with these mieroseopes the automatic Combiphot 11 camera sys- tem and a discussion tube attachment mounted on top for multiple viewing will be displayed. New EF flatfield objectives will be featured on these soopes for both brightfield and phase contrast applications. Their Dialux 20 and Orthoplan microscopes will be representative of their research line. The Varion Orthomat with pan- ciatic eyepiece. 5x-12.sx, and the MPV Compact will be displayed with these microscopes. The Dialux 20 will illustrate the simplicity or incident light fluores- cence work with the Ploemopak 2.4 illuminator. The Rotary Mlcrotome 1512 and Photomacrosoope will also be displayed. 17V 5240 43

NUAIRE INC. BOOTH 10 3964 Winnetka Ave. N. Minneapolis, MN 55427 6121545-0281 They will be displaying a Class II. Type B Biological Safety Cabinet. Thevl manufacture a complete line of Biological Safety Cabinets, Clean Benches. Work Sta- tions, Ceiling Modules, and other Lammar Airflow Equipment. NUCLEAR ASSOCIATES BOOTH 23 100 Voice Rd. Carle Place, NY 11514 5161741.9860 Intracavitary and interstitial radiat on medical products for brachytherapy and teletherapy including. Selectron Remote Control Aitedoading System. Cesium-137 afterloading tube, Micrad Cesium-137 afterloadmg, Atterloading and direct loading cesium-137 needle. Afterloading cestum-137 hairpin sources. Note: Inac- tive. dummy sources will be displayed. Atterloading Applicators: Fletcher-Sun, Delclos, Henschke. Simon- Heyman, Simon•SiIverstone, Botstem-Zacharopoulos. Burnett, and Suda-Chary. Treatment planning aids and accessories. ORTHO INSTRUMENTS BOOTHS 11, 12 410 University Ave. Westwood, MA 02090 6171329-6100 Manufacturers of laser based chrycal and research flow cytometers, cell sorters, and computerized data ac- quisition, display ano sorter control systems. PLENUM PUBLISHING CORP. BOOTH 2 227 West 17th St. ' New York, NY 10011 2121255-0713 Becker's Cancer Treatise, 6 volumes; Comprehensive Immunology. 9 volumes, Series Eds. Robert A. Good end Stacey B. Day: The Reticuloendothelial System. A ComprehPnsive Treatise. Eds. Fnedman, Escobar. end Reichard; Monoclonal Antibodies, Eds. Kennett, McKeam, and Bechtol; Inhibition of Tumorigenesis. Eds. Zedeck and Lipkin; In.Situ Expression of Tumor , Immunity, Eds.. Witz and Hanna; Introducing the Jour- nal of Clinical Immunology, ed. Sudhir Gupta. RAVEN PRESS BOOTH 21 1140 Ave. of the Amerieas New York, NY 10036 21121576413115 They publish thefollowing eight major series on cancer: Biopsy Interpretation Series; Carcinogenesis: A Com- prehensive Survey; EORTC Monograph Series; M. D. Anderson Clinical Conferences on Cencer; M. D. An- derson Series on the Diagnosis end Management of Cancer; M. D. Anderson Symposia on Fundamental Cancer Research; Pathobrology Annual; and Progress in Cancer Research and Therapy. RESEARCH AGAINST CANCER, INC. BOOTH, 25 2648 Crane Ridge Dr. Jackson, MS 39216 601/981•7143 They manufacture a system of investigational medical devices for use in clinical trials of eKtracorporeal hy-, perthermia as a new modality for cancer treatment. Their products include a temperature regulating device; TRD. which autoregulates patient temperature within .01 degree Celsius for treatment periods from 3 to Ej hours, a TDMAC-treated disposable extracorporeal cir- cuit and an implantable shunt device. SMITHKLINE DIAGNOSTICS BOOTH I 880 W. Maude Ave. ' PO. Box 61947 Sunnyvale, CA 94086 408/7324Q00 They will feature Hemoccults, a test fpr fecal occult blood. More than 114,000 cases of coiorectal cancer will occur this year in the United States alone. Hem- occutts is a convenient, dependable. virtua,lly odorless preliminary screening test for abruarmal gi. bleeding often associated with coloreclal cancer. Representa- tives will discuss more about Hemoccufta and its im- portant role in the early detection of cotorectal canced.

SFPIINGER-VERLAG NEW YORK, INC. BOOTIi 7 175 Fifth Ave. Neeiv York, NY 10010 2121477-8347 Comprehensive Manuals of Sur$ical Specialities; R.E. Hermann: Manual of Surgery of the Gallbladder. Bile Ducts and Exocrine Pancreas; B.J; Masterson: Manual of Gynecologic Surgery; Recent Results in Cancer Re- search: Volume 70: S.K. t;,arter,, Y. Saki,,tai-iaditors, New Anticancer Drirgs; Monographs: K. Lennert, Ma• lignant Lymphomas,; M.J. Musphy, Jc=ednor, Invitro Aspects of Eryrhro~oiesis; W.W, Park. The Histology of Bordedine Cancer; W.E. Stewart II, The Interferon System. STUART PHAR(1AACEUTfCALS BOOTH 27 Concord IPk. & Murphy Rd. Wilmington, DE 19897 802/575-2225 They will feature Nolvadexs, tamoxifen citrate, a new approach to the oral palliative treatment of advanced breast cancer in postmenopausal women. Represen• tatiWes will be glad to answer any question on Nolvadex and will accept reqhests for printed literature. ULSTER SCIENTIFIC INC. BOOTH 5 531VIain St. Highland, NY 12528 914/6914226 Autolet-small, r; vtable device which compietety and painlessly eutoma-~ s capillary blood letting; Bio-Hazard BAG-polypropylene bag. heat•resistant, autoclavabie, complete with OSHA regulation printed on bag: Tndak Stepper-repetitive micro-pipette, uses BD syringes for dispensing; Excalibur--micropipette, with cehbra- tion capability and ejection; Pipette Tips-Available in bulk, special and tray packaging. Precision molded out of polypropylene; Squeezers-disposabie plastic trans- fer pipettes, with graduation marks on two of the four in the series. 46 .» i RIOTES 5242 47