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Frank J. Rauscher, Jr., Ph.D. Senior Vice President for Research American Cancer Society Vincent T. DeVita. Jr., M.D. Drrector, National Cancer Institute PROGRAM COMMITTEE Chairman: Joseph H. Burchenal. M.D. Director, Clinical Investigation Memorial Sloan-Kettering Cancer Center New York, NY Members; Bayard D. Clarkson. M.D. Chief. HematologY/Lymphoma Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York. NY Jerome J. DeCosse. M.n. Chairman. Department of Surgery Memorial Sloan-Kettering Cancer Center New York. NY Vincent T DeVita. Jr.. M.D. Director, National Cancer Institute National Institutes of Health Bethesda, MD William S. Howland. M.D. Vice President for Clinical Affairs Memorial Sloan-Kettering Cancer Center New York, NY Mathilde Krim, Ph.D. Associate Member, Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center New York. NY LaSalle D. Leffall, Jr., M.D. Immediate Past President, American Cancer Society Professor & Chairman, Department of Surgery Howard University CMlege of Medicine VVashington, DC s_ a ;.zP ;~.,i~ Damel G. Miller. M.D. . Director. Preventive Medicine Institute Strang Clinic New York, NY Denis R. Miller, M.D. Chairrutan, Department of Pediatrics Memoria/ Sloan-Ket'tenng Cancer Center New ti'ork. NY Herbert F Oettgen, M.D. Chief, Clwnical Immpnotogy Service Department of Medicme Memorial Sloan-Kettering Cancer Center New York. NY Lloyd J. K)Id, M.D. Vice President & Assopiate Director for Scientific Development Sloan-Kettering Institute Memoriat Sloan-Kettering Cancer Center New York, NY Richard J. O'Reilly, M.D. Director, Bone Marrow Transplantation Program Memorial Sloan-Ketkedng Cancer Center New York. NY Frank J. Rauscher, Jr., Ph.D. Senior Vpce President for Research American Cancer Societiy, Inc. New York, NY William R. Shapiro. M.D. Anending Neurologist Memorial Sloan-Kettering Cencer Center New York, NY Paul Sherlock, M.D. Cnarrman. Department of Medicine Memorial Sloan-Kettering Cancer Center New York. NY Charles 1N. Young, M.D; Chief, Developmental Chemotherapy Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York, NY Ex Officio: t Edward J. BeatGe. Jr.. EUI.D. General Director & ChiO Medical Officer. Memorial Hospital Memorial Sloan•Ktmering Cancer Center New York, NY ®lN1 5222 ..: -7

Robert A. Good, Ph.D., M.D. Vice President, Memonal Sloan•Kettering Cancer Center New York, NY SYMPOSIUM STAFF Program Coordinator: Ms. Leslie M. Anton Registrar: Mrs. M. Virginia Herhtz Meetmg and Exhibit Management: Sceven K. Herhtz, Inc. CANCER INFORMAT10N SERVICES Ly+4IBIT Registration Area Cancer research scientists and clinicians are encour- aged to visit a display oi the cancer information serv ces available through the Internatiqnal Cancer Research Data Bank (ICRDB) Program of the National Cancer Institute. These services include computer data bases deaNng with CANCER LITerature, (the CANCERLIT data base), and summaries of CLINICAL PROTocols (the CLINPROT data base). In addition to the three data bases (collectively called CANCERLINE), the ICRDB Program disseminates 65 monthly current awareness bulletins caIled CANCERGRAMS. each containing about 25-100 abstracts in different major areas of cancer re- search. A COMPILATION OF CANCER THERAPY PRO- TOCOL SUMMARIES is also published annually. e- ...Si'°.. SURIDAY, SEPTEMBER 14 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Lewis Thomas, M.D. New York, NY Joseph H. Burchenal. M.D. New York. NY B:30 AM AIMS OF THE CONFERENCE eeino C. Schmidt New York, NY 6:50 AM PURPOSES OF THE NATIONAL CANCER ACT Frank J. Rauscher, Jr., Ph.D. New York, NY 9:15 AM EPIDEMIOLOGY FOR CLUES TO ETICILOGY John Higginson, M.D. Lyon. France 10:00 AM VIRUSES AND CANCER George Klein, M.D., D.Sc. Stockholm. Sweden 10:45 AM COFFEE BREAK 11:15 AM RADIATION HAZARDS Arthur C. Upton, M.D. New York. NY 12:00 PM INDUSTRIAL AND LIFE-STYLE CARCINOGENS Michael B. Shimkin, M.D. Le Jolla, Ca 12:45 PM Ll/NCH I Z NI 5223 -9 : ..... :;i~. i

SYMPOSIUM 1-Empire State Ballroom C Fifth Floor Grand Hyatt Hotet 2:00-5:00 PM EPIDEMIOLOGY Chairman, John Higgmson, M.D. Lyon, France AN'ALYTIC EPIDEMIOLOGY Philip Cole, M.D., Dr. P.H. Br.mingham, AL THE INTERPHASE BETWEEN EPIDEMIOLOGY AND CANCER CONTROL POLICY Sir Richard Doll, M.D. Oxford. United Kingdom COFFEE BREAK DESCRIPTIVE EPIDEMIOLOGY AND GEOGRAPHICAL PATHOLOGY Brian E. Henderson, M.D. Los Angeles. CA LIFESTYLE FACTORS IN HUMAN CANCER Anthony B. Miller, M.B. Toronto, Canada SUNDAY, SEPTEMBER 14 SYMPOSIUM 2-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM VIRUSES Chairman: George Klein, M.D., D.Sc. Stockholm. Sweden TRANSFORMATION BY SMALL DNA VIRUSES Thomas L. Benjamin. Ph.D. Boston. MA MECHANISM OF TRANSFORMATION BY AVIAN AND MURINE RNA TUMOR VIRUSES Peter Duesberg. Ph.D. Berkeley, CA FELINE LEUKEMIA AND SARCOMA VIRUSES Myron Essex, D.V.M., Ph.D. Boston. MA COFFEE BREAK EBV: ITS RELATION TO BURKITTS LYMPHOMA AND NASOPHARYNGEAL CARCINOMA Gertrude Henle, M.D. Philadelphia, PA V1~emer Henle, M.D. Philadelphia. PA HEPATlTIS B-VIIRUS1AND HEPATOMA Baruch S. Blumberg. M.D.. Ph.D. Philadelphia, PA I z M 5224 _1,

SYMPUSIUM 4-Empire State Ballroom D Fifth FIcWr Grand Hyatt Hotel 2:D0•5:00 pM INDUSTRIAL AND LAFE.•S7YLE CARCINOGENS Chairman: Michael B. Shimkin, M.D. La Jolla, CA METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS Elizabeth C. Miner, Ph.D. Madison. WI DETECTIION OF CARCINOGENS Jeffrey C. Theiss. Ph.D. Houston, TX EPIDEMiOLOCIC EVIDENCE Irving J. Selikoff. M.D. New York, NY COFF-te BREAK THE ROLE OF POPULATION-BASED TUMOR REGISTRIES IN IDENTIFYING OCCUPATIONAL CARCINOGENS Donald F. Austin. M.D. Oakland. CA PU@LIlr'POLICY LEGISLATION David Rall, M.D., Ph.D. Research Triangle Park, NC I b

Rf~ONDAY, SEPTEMBER 15 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Frank J. Rauscher. Jr.. Ph.D. New York, NY Paul Marks, M.D. New York, NY 8:30 AM ' HrJST DEFENSE AGAINST CANCER Herbert F. Oettgen, M.D. New York. NY 9:;15 AM GENETICS AND CANCER Aitred G. Knudson, Jr.. M.D., Ph.D. Philadelphia, PA 10:00 AM COFFEE BREAK 1 fd,:30 AM CELL BIOLOGY AND CANCER John Caims, M.D., Ph.D. London. England 11:15AM PREVENTION OF CARCINOGENESIS Lee W. Wattenberg, M.D. Minneapolis, MN 12,:00 PM LOCALIZED DISEASE-THE CURE WITHIN OUR GRASP Daniel G. Miller, M.D. New York, NY 12;45 PM LUNCH ®1 N 1 55226 _,s

SYMPOSIUM 6-Oval Room Lobby Level Roosevelt Hotel 2:00•5:00 PM GENETICS Chairman: Alfred G. Knudson, Jr., M.D . Ph D Philadedphia, PA THE GENETIC EPIDEMIOLOGY OF HUMAN CANCER: BREAST CANCER AS AN EXAMPLE M7ry•Claire King, Ph.D. Berkeley. CA SPECIFIC FINE STRUCTURAL CHROMOSOME DEFECTS IN HUMAN NEOPLASIA Jorge J. Yunis. M.D., Ph.D Minneapolis, MN COFFEE BREAK CLINICAL FEATURES OF GENETIC CANCER Fredenck P Li. M.D. Boston, MA CHROMOSOME 1411N BENIGN AND MAdi GNANT LYMPHOID CANCER Frederick Hecht, M.D. Tempe. AZ ON 5227 -17

ftflONDAY, SEPTEMBER IS SYMPOSIUM 7-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM CELL BIOLOGY AND CANCER Chairman: John Carrns, M.D., Ph.D. London, United Kingdom EVOLUTION OF THE MALIGNANT PHENOTYPE IN AN EPITHELIAL CANCER AS SEEN IN THE CASE OF MOUSE MAMMARY Daniel Medina. Ph.D. Houston, TX SUPPRESSION OF MYELOID LEUKEMIC CELLS BY BIOLOGICAL REGULATORS Donald Metcati, M.D. Melbourne. Australia CELLULAR AND HOST ASPECTS OF TUMOR METASTASIS Garth L. Nitolson, Ph.D. Houston, TX HIGH EFFICIENCY, KINETICS AND NUMEROLOGY OF TRANSFORMATION BY RADIATION 1N VITRO Ann R. Kennedy. S.D. Boston, MA STATUS OF STUDIES ON THE EXACT PHENOTYPE OF CANCER CELLS Robert Poilack, Ph.D. New York, NY te- MONDAY SEPTEMBER 15 SYMPOSIUM 8-Empire State Ballroom C Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM PREVENTION OF CARCINOGENESIS Charrman: Lee W. Wattenberg, M.D. Minneapolis, MN CHEMOPREVENTION OF NEOPLASIA WITH RETINOIDS Michael B. Spom, M.D. Bethesda, MD BLOCKING OF TUMOR PROMOTION BY PROTEA$E INHIBITORS Walter Troll, Ph.D New York. NY INHIBITION OF FORMATION OF CARCINOGENIC NITROSAMINES AND NITROSAMIDES Sidney Mnvish, Ph.D. Orrraha, NB COAFE'€ BREAK REDUCTION IN THE FORMATION OF MUTAGENS AND CARCINOGENS IN THE LARGE BOWEL OF MAN W. Robert Bruce, M.D.. Ph.D. Toronto, Canada DIETARY, FACTORS IN THE CAUSATION AND PREVENTION OF NEOPLASIA John Weisburger. Ph.D. Valhalla, NY 5228 -t9

RAOIiIOAY, SEPTEMBER 15 SYMPOSIUM 9-Empire State Ballroom B Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM ADVANCES IN DIAGNOSIS Chadrmen: Daniel 6. Miller, M.D. New York. NY Sidney J. Wmawer, M.D. New York, NY BIOCHEMICAL AND IMMUNOLOGIC DIAGNOSIS OF CANCER Morton K. Schwartz, Ph.D. New York, NY NUCLEAR IMAGING IN CANCER DIAGNOSIS Henry N. Wagner, Jr.. M.D. Baltrmore, MD RADIOLOGIC ADVANCES IN CANCER DIAGNOSIS Michael Deck. M.D. Nsw York. NY COFFEE MEAK EARLY DIAGNOSiS OF LIVER CANCER AND ITS PRECEDING STAGE THROUGH AFP SEROLOGY Sun Tsung•Tang. M.D. 6eq!ng. People's Republic of China CYTOLOGIC ADVANCES IN - CANCER CONTROL Myron R. Melemed. M.D. New York, NY ADVANCES IN DIAGNOSIS OF GASTROINTESTINAL NEOPLASMS H. Worth Boyce. Jr., M.D. Tampa. FL I RIOTES 5229 . .. . ~ -u~. .__. -21 I

TUESDAY, SEPTEMBER 16 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Vincent T. DeVita. Jr.. M.D. Bethesda, MD C Chester Stock. Ph.D. New York. NY 8:30 AM DEVELOPMENT OF,ANTICANCER THERAPY C. GordonZubrod, M.D Miami, FL 9:10 AM Li4BORATORY METHODS FOR THE DETECTION AND DEVELOPMENT OF CLINICALLY USEFUL ANTICANCER DRUGS Frank M. Schabel. Jr., Ph.D Birmingham. AL 9:50 AM PHARMACOLOGY Emil Fret. III, M.D. Boston, MA 10:30 AM COFFEE BREAK 11:0D AM PEDIATRIC OVERVIEW Denman Hammond. M.D. Los Angeles. CA 11:40 AM LEUKEMIA OVERVIEW Joseph H Burchenal, M.D. New York. NY 12:20 PM CARCINOMA OF THE BREAST Ganni Bonadonna, M.D. Mdan, Italy 1:00 PM LUNCH IUESDAY, SEPTEMBER 16 SYMPOSIUM 10-Terrac.e Room Lobby Level Roosevelt Hotel 2:00-5:00 PM bEVELOPMERITAL THE:RAPY Chairmen: Frank M. Schabel. Jr., Ph.D. Birmingham. AL C. Gordon Zubrod. M.D. Miami, FL APPLICATIONS OF THE HUMAN TUMOR STEM CELL ASSAY IN THE DEVELOPMENT OF ANTICANCER THERAPY Sydney E. Salmon, M.D. Tucson, AZ DRUG STUDIES IN XENOGRAFTS OF HUMAN SOLID TUMORS Awatar Krishan. Ph.D. Miami. FL ACQUIRED RESISTANCE TO THERAPEUTIC AGENTS Robert W. Brockman. Ph.D. g!rmingham, AL COFFEE BREAK RATIONALE FOFt CONGENER SY16'TH€5IS John A. Montgomery Ph.D. Birmingham. AL CONTROL OF METASTASES BY MACROPHAGES ACTIVATED WITH AGENTS ENCAPSULATED WITHIN LIPOSOMES Isaiah J. Fidler, Ph.D., D.V.M. Frederick. MD 2z _ ®1Z N 5 230 - 23

TUESDAY, SEPTEMBER 16 SYMPOSIU M 11-Oval Room Lobby Level Roosevelt Hotel 2:00-5:00 PM PHARMACOLOGY Chairman: Emil Frei. III, M.D. Boston, MA MODULATION OF ANTINEOPLASTIC THERAPY BY NUCLEOSIDES AND BY DRUG II•iTERACTIONS Bruce A. Chabner, M.D. Bethesda, MD PHARMACOLOGIC IMPLEMENT4TION OF CELL DIFFERENTIATION: MECHANISMS AND ROLE IN CANCER THERAP1f Gerald C. Mueller, M.D., Ph.D. Madison. WI BIOLOGICAL RESPONSE MODIFIERS Ennco Which, M.D. Buffalo. NY COFFEE BREAK PHARMACOLOGY OF NEW CANCER CHEMOTHERAPY AGENTS Ti Li Loo. Ph.D. Houston, TX PRE-CLINICAL TOXICOLOGY AND PHASE I Frederick S. Phi6ps. Ph.D New York, NY Charles W Young, M.D. New York, NY 2a - 4 I l TUESDAY, SEPTEMBER 16 SYMPOSIUM 12-Empire State Ballroom B Fifth Floor Grand Hyatt Hotel 2:00-5:00 PM PEDIATRIC TUMORS Cha rman: Denman Hammond, M.D. Los Angeles, CA WILMS' TUMOR Giulio J. D'Angio, M.D. Philadelphia, PA RHABDOMYOSARCOMA Harold M. Maurer. M.D. Richmond, VA BONE TUMORS Gerald Rose,n, M.D. New York. NY COFFEE BREAK NON-HODGKIN'S LYMPHOMA Stuart E Siega!, M.D. Los Angeles. CA NEUROBLASTOMA Alvin M. Mauer. M.D. Memphis TN 523t - 25 I