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09111,111111 ~t1e National CaiicerYnsti.ti.itc'.an the A'.mencan Cancer Society pcerEnted b}'.. ' emo~ial S1oan=Ketteriri~ • ` : - ~.Cancer.Center :. .

HOTELS GRAND HYATT HOTEL (HEADQUARTERS) Park Avenue at Grand Central New York. NY 10017 (212) 883-1234 THE ROOSEVELT HOTEL Madison Avenue at 45th Street New York, NY 10017 " (212) 661-9600 THE BILTMORE HOTEL Madison Avenue at 43rd Street New York, NY 10017 (212) 687-7000 REGISTRATION Foyer outside Empire State Ballroom, F•rftA Floor, Grand Hyatt Hotol Admission to Sessions, Exhibits and Coffee Lounges by Badge only. Registratian Hours: Seturdav. September 13.......... .1:00 p.m. to 8:00 p.m. Sunday, September 14 .............7:00 a.m. to 5:00 p.m. Monday, September 15............ 7:30 a.m. to 5:00 p.m. Tuesday, September 16............7:30 s.m. to 5:00 p.m. Wednesday. September 17...... 7:30 a.m. to 5:00 p.m. Thursday. September 18........... 7:30 a.m. to 1:00 p.m. EXHIBIT HOURS Sundat, September 14 ..... ....... 8:00 e.m. to 4:00 p.m. Monday, September 15............ 8:00 a.m. to 4:0!0 p.m. Tuesday. September 16............ 8:00 e.m. to 4:00 p.m. Wednesdey, September 17......8:00 a,m. to 5:0n p.m. Exhibits are lo;:ated on the Fifth Floor. Grand Hyatt Hotel. For exhibit descdptions, please see Pages 38 to46. .. :t..~ .~ -U 1-":".S~p`0W'j~' ''' i',ir'r:"•_' J i ZN 5219 -1

SYMPOSIUM OFFICE The Symposium, office in the Uns Room on the Fourth Floor in the Grand Hyatt Hotel will be open after 1:00 p.m. on Saturday, Septem4er 13, and will remain open during regostration hours through Thursday, Sep- tember 18. Symposium Office Director: Mrs. M. Virginia Herhtz SPEAKERS'NEADQUARTERS The Speakers' Headquarters are located in the Alvin Room, Fourth Floor, Grand Hyatt Hotel. AII program palticipants shohld report to the Alvin Room to receive their badge and other pertinent material. Speakers' Room Director: Ms. Leslie M. Anton INFORMATION AND MESSAGE CENTER The Information and Message Center will be located in the Registration Area. Registration cards of all participants are filed in the Visible Directory located in the Registration Area. Registrants shoWd check daily for telephone mes- sages, notes and mail. PRESS ROOM The Press Room is located in the Broadway Room on the Fourth Floor of the Grand Hyatt Hotel. Members of the Press should report to the Broadway Room to receive the official press badge. Interview facilities wfll be provided. Saturday ...................................1:00 p.m. to 5:00 p.m. Sunday through rlVednesday...8:00 a.m. to 5:30 p.m. Thursday ............ :...................... B:00 a.m. to 2:30 p.m. Press Room Director: Ms. Patricia Mohno 2- LOST AND FOUND Inquiries concerning lost articles should be made at the Symposium Headquarters Office. Articles found should be delivered to the Symposium Office. Slides left in session rooms will be delivered herc by projec- tion operators. REQUEST FOR °NO SMOXING- It is requested that all registrants refrain from smoking in the meeting rooms and exhibit area. COMTINUING MEDICAL EDUCATION As arw organiiation accredited for Continuing Medical Education, Memorial Sloan-Kettering Cancer Center designates this Continuing Medical Education activity as meeting the criteria for 34 credit hours in Cate- gory I of the Physician's Recognition Award of the American Medical Association. Registrants who meet the requirements for partici- pation, in this continuing educational orogram will re- ceive a statement of certification of participation fol- towinp, the meeting. Announcementsof the procedures will be made at each session during the progrr3m. A Continuing Medical Education booth will be located in the Reglistration Area. AUDIO TRANSCRIP:'S All scietrtific sessions will be instantly transcribed and available Yor purchase on site. The Audio Transcripts desk will be located in the Registration Area, Fifth Ftoor, Grand Hyatt Hotel. HOSPITALITY DESK The Hospitality Desk will be rocated in the Registration _Area 5220 - 3

1980 Inteinational Symposium on Cancer General Chairman: Edward J. Beattie, Jr., M.D General Director & Chief Medical Officer, Memorial Hospital Memoria; Sloan-Kettering Cancer Center New York, NY Vice Chairnian: William 5. F9owland, M.D. Vice President for Clinical Affairs Memorial Sloan-Kettering Cancer Center New York. NY Advisory Committee: Laurdnce S. Rockefeller Chairman of, the Board Memorial Sloan-Kettenng Cancer Center Benno C. Schmidt 03irman of the Board Memorial Hospital Fred Seitz, Ph D. Chairman of the Board Sloan-Kettering Institute James D. Rmbinson, Ili Vice Chairman of the Board Memorial Hospital Lewis Thomas. M.D. Chancellor, Memorial Sloan-Kettering Cancer Center Robert A. Good. Ph.D.. M.D. Vice President Memorial Sloan-Kettering Cancer Center Lane W Addms Executive Vice President American Cancer Society Arthur I. Holleb. M.D. Senior Vice aresident for Medical Affairs American Cancer Society

Frank J. Rauscher, Jr., Ph.D. Senior Vice President for Research American Cancer Society Vincent T. DeVita. Jr., M.D. Drrector, National Cancer Institute PROGRAM COMMITTEE Chairman: Joseph H. Burchenal. M.D. Director, Clinical Investigation Memorial Sloan-Kettering Cancer Center New York, NY Members; Bayard D. Clarkson. M.D. Chief. HematologY/Lymphoma Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York. NY Jerome J. DeCosse. M.n. Chairman. Department of Surgery Memorial Sloan-Kettering Cancer Center New York. NY Vincent T DeVita. Jr.. M.D. Director, National Cancer Institute National Institutes of Health Bethesda, MD William S. Howland. M.D. Vice President for Clinical Affairs Memorial Sloan-Kettering Cancer Center New York, NY Mathilde Krim, Ph.D. Associate Member, Sloan-Kettering Institute Memorial Sloan-Kettering Cancer Center New York. NY LaSalle D. Leffall, Jr., M.D. Immediate Past President, American Cancer Society Professor & Chairman, Department of Surgery Howard University CMlege of Medicine VVashington, DC s_ a ;.zP ;~.,i~ Damel G. Miller. M.D. . Director. Preventive Medicine Institute Strang Clinic New York, NY Denis R. Miller, M.D. Chairrutan, Department of Pediatrics Memoria/ Sloan-Ket'tenng Cancer Center New ti'ork. NY Herbert F Oettgen, M.D. Chief, Clwnical Immpnotogy Service Department of Medicme Memorial Sloan-Kettering Cancer Center New York. NY Lloyd J. K)Id, M.D. Vice President & Assopiate Director for Scientific Development Sloan-Kettering Institute Memoriat Sloan-Kettering Cancer Center New York, NY Richard J. O'Reilly, M.D. Director, Bone Marrow Transplantation Program Memorial Sloan-Ketkedng Cancer Center New York. NY Frank J. Rauscher, Jr., Ph.D. Senior Vpce President for Research American Cancer Societiy, Inc. New York, NY William R. Shapiro. M.D. Anending Neurologist Memorial Sloan-Kettering Cencer Center New York, NY Paul Sherlock, M.D. Cnarrman. Department of Medicine Memorial Sloan-Kettering Cancer Center New York. NY Charles 1N. Young, M.D; Chief, Developmental Chemotherapy Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York, NY Ex Officio: t Edward J. BeatGe. Jr.. EUI.D. General Director & ChiO Medical Officer. Memorial Hospital Memorial Sloan•Ktmering Cancer Center New York, NY ®lN1 5222 ..: -7

Robert A. Good, Ph.D., M.D. Vice President, Memonal Sloan•Kettering Cancer Center New York, NY SYMPOSIUM STAFF Program Coordinator: Ms. Leslie M. Anton Registrar: Mrs. M. Virginia Herhtz Meetmg and Exhibit Management: Sceven K. Herhtz, Inc. CANCER INFORMAT10N SERVICES Ly+4IBIT Registration Area Cancer research scientists and clinicians are encour- aged to visit a display oi the cancer information serv ces available through the Internatiqnal Cancer Research Data Bank (ICRDB) Program of the National Cancer Institute. These services include computer data bases deaNng with CANCER LITerature, (the CANCERLIT data base), and summaries of CLINICAL PROTocols (the CLINPROT data base). In addition to the three data bases (collectively called CANCERLINE), the ICRDB Program disseminates 65 monthly current awareness bulletins caIled CANCERGRAMS. each containing about 25-100 abstracts in different major areas of cancer re- search. A COMPILATION OF CANCER THERAPY PRO- TOCOL SUMMARIES is also published annually. e- ...Si'°.. SURIDAY, SEPTEMBER 14 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Lewis Thomas, M.D. New York, NY Joseph H. Burchenal. M.D. New York. NY B:30 AM AIMS OF THE CONFERENCE eeino C. Schmidt New York, NY 6:50 AM PURPOSES OF THE NATIONAL CANCER ACT Frank J. Rauscher, Jr., Ph.D. New York, NY 9:15 AM EPIDEMIOLOGY FOR CLUES TO ETICILOGY John Higginson, M.D. Lyon. France 10:00 AM VIRUSES AND CANCER George Klein, M.D., D.Sc. Stockholm. Sweden 10:45 AM COFFEE BREAK 11:15 AM RADIATION HAZARDS Arthur C. Upton, M.D. New York. NY 12:00 PM INDUSTRIAL AND LIFE-STYLE CARCINOGENS Michael B. Shimkin, M.D. Le Jolla, Ca 12:45 PM Ll/NCH I Z NI 5223 -9 : ..... :;i~. i

SYMPOSIUM 1-Empire State Ballroom C Fifth Floor Grand Hyatt Hotet 2:00-5:00 PM EPIDEMIOLOGY Chairman, John Higgmson, M.D. Lyon, France AN'ALYTIC EPIDEMIOLOGY Philip Cole, M.D., Dr. P.H. Br.mingham, AL THE INTERPHASE BETWEEN EPIDEMIOLOGY AND CANCER CONTROL POLICY Sir Richard Doll, M.D. Oxford. United Kingdom COFFEE BREAK DESCRIPTIVE EPIDEMIOLOGY AND GEOGRAPHICAL PATHOLOGY Brian E. Henderson, M.D. Los Angeles. CA LIFESTYLE FACTORS IN HUMAN CANCER Anthony B. Miller, M.B. Toronto, Canada SUNDAY, SEPTEMBER 14 SYMPOSIUM 2-Terrace Room Lobby Level Roosevelt Hotel 2:00-5:00 PM VIRUSES Chairman: George Klein, M.D., D.Sc. Stockholm. Sweden TRANSFORMATION BY SMALL DNA VIRUSES Thomas L. Benjamin. Ph.D. Boston. MA MECHANISM OF TRANSFORMATION BY AVIAN AND MURINE RNA TUMOR VIRUSES Peter Duesberg. Ph.D. Berkeley, CA FELINE LEUKEMIA AND SARCOMA VIRUSES Myron Essex, D.V.M., Ph.D. Boston. MA COFFEE BREAK EBV: ITS RELATION TO BURKITTS LYMPHOMA AND NASOPHARYNGEAL CARCINOMA Gertrude Henle, M.D. Philadelphia, PA V1~emer Henle, M.D. Philadelphia. PA HEPATlTIS B-VIIRUS1AND HEPATOMA Baruch S. Blumberg. M.D.. Ph.D. Philadelphia, PA I z M 5224 _1,

SYMPUSIUM 4-Empire State Ballroom D Fifth FIcWr Grand Hyatt Hotel 2:D0•5:00 pM INDUSTRIAL AND LAFE.•S7YLE CARCINOGENS Chairman: Michael B. Shimkin, M.D. La Jolla, CA METABOLIC ACTIVATION OF CHEMICAL CARCINOGENS Elizabeth C. Miner, Ph.D. Madison. WI DETECTIION OF CARCINOGENS Jeffrey C. Theiss. Ph.D. Houston, TX EPIDEMiOLOCIC EVIDENCE Irving J. Selikoff. M.D. New York, NY COFF-te BREAK THE ROLE OF POPULATION-BASED TUMOR REGISTRIES IN IDENTIFYING OCCUPATIONAL CARCINOGENS Donald F. Austin. M.D. Oakland. CA PU@LIlr'POLICY LEGISLATION David Rall, M.D., Ph.D. Research Triangle Park, NC I b

Rf~ONDAY, SEPTEMBER 15 PLENARY SESSIONS EMPIRE STATE BALLROOM Fifth Floor Grand Hyatt Hotel Presiding: Frank J. Rauscher. Jr.. Ph.D. New York, NY Paul Marks, M.D. New York, NY 8:30 AM ' HrJST DEFENSE AGAINST CANCER Herbert F. Oettgen, M.D. New York. NY 9:;15 AM GENETICS AND CANCER Aitred G. Knudson, Jr.. M.D., Ph.D. Philadelphia, PA 10:00 AM COFFEE BREAK 1 fd,:30 AM CELL BIOLOGY AND CANCER John Caims, M.D., Ph.D. London. England 11:15AM PREVENTION OF CARCINOGENESIS Lee W. Wattenberg, M.D. Minneapolis, MN 12,:00 PM LOCALIZED DISEASE-THE CURE WITHIN OUR GRASP Daniel G. Miller, M.D. New York, NY 12;45 PM LUNCH ®1 N 1 55226 _,s

SYMPOSIUM 6-Oval Room Lobby Level Roosevelt Hotel 2:00•5:00 PM GENETICS Chairman: Alfred G. Knudson, Jr., M.D . Ph D Philadedphia, PA THE GENETIC EPIDEMIOLOGY OF HUMAN CANCER: BREAST CANCER AS AN EXAMPLE M7ry•Claire King, Ph.D. Berkeley. CA SPECIFIC FINE STRUCTURAL CHROMOSOME DEFECTS IN HUMAN NEOPLASIA Jorge J. Yunis. M.D., Ph.D Minneapolis, MN COFFEE BREAK CLINICAL FEATURES OF GENETIC CANCER Fredenck P Li. M.D. Boston, MA CHROMOSOME 1411N BENIGN AND MAdi GNANT LYMPHOID CANCER Frederick Hecht, M.D. Tempe. AZ ON 5227 -17