Council for Tobacco Research
Cancer Select Committee Calls Virus Program A Closed Shop [Virus Cancer Program Has Provoked Controversy Ever Since It Began As An Effort to Determine Whether Viruses Cause Human Cancer and If So to Do Something About It]
Fields
- Type
- ARTICLE
- Depository Date
- 29 Mar 1996
- Named Person
- Edwards, C.C.
- Natl Cancer Advisory Board
- Nci
- Nih
- Science
- Schmidt, B.C.
- Zinder, N.
- Rockefeller Univ
- Rauscher, F.J.
- Wade, N.
- Moloney, J.
- Nixon, R.
- Natl Conference, O.N. Virology And Immunology, I.N. Human Cancer
- Blesser
- Stockman, T.
- Univ, U.T.
- Natl Cancer Advisory Board
- Request
- 135
- Author
- Culliton, B.J.
- Box
- 140
- Site
- Zahn
- UCSF Legacy ID
- ewb3aa00
Document Images
posed of thtree principal frequencies to restore the conversation in the
called formants. The precise fhape of ~ erased 18 minutes and in any other
the formants in each sound is influ- gaps that may come to light. The 20
enced by those of the preceding sound. July tape is already undergoing tests
Thus if the word "not" were excised in the laboratories of the Federal
from the phrase `He was not involved;' Scientific Cqrporation in New York.
rne t»rrnants, 01 the "i auureu' vt sn- A me,vioer hf tlte 5itiea ,Nw.n
volved" would still indicate that the R. Weiss. is the corporation's vice-
"i" had actually been preceded by a president for acoustic research. At this
"t", not an "s." stage, it seems that, in order to resur-
: .'^i.. cac a".! her PM rhe erased portions of the 20 July
methods of detection? "In overview if tape, it will be necessary to subtract the
looks rather impossible," Blesser says. hums apparently made by the electric
"But given enough time and equipment typewriter and tensor lamp in the office
and expertise you could make your of the Presid;nt's seeretary. With the
editing undetectable." There are prob hum removed, the hiss that remains
ably no more than a hundred people in can undergo signal enhancement anal-
the country who are even aware of all ogous to that used to process the video
the technical issues. Only it the wnitc piutwua sttit l.aa: b; t:pa:csaft. Ti:ic
House had access to the National Secur- kind of processing is apparently a
ity Agency ot the CIA could they get a standard technique in the intelligence
perfect editing job done, Blesser be- communityr without it, the low grade
lieves. Other experts feel that detection reco,rdings obtained from the bugging
of a well-edited tape is far from certain. of embassies and the like would be
"You can't guarantee that you can virtually useless. Certain of the panel
detect very professionally done altera- members have access to the intelligence
tions." says Amar G. Bose, professor agencies or aheir contractors who have
of electrical engineering at MIT and the necessary, expertise.
chairman of Bose Electronics. A simpler way of restoring the lost
Besides testing the authenticity of portion may be available if the heads
the tapes. Sirica's panel will also try of Miss Wotids s tape recorder, as is
I
l
Cancer: Select Committee Calls
Virus Program a Closed Shop
The lau few weeks have not been
all that one might hope for the nation's
premier biomedical research enterprise
-the war to conquer cancer. First,
assistant sectetary for health Charles
C. Edwards declared the whole opera-
tion an "administrative mistake." Then,
a special committee of the National
Cancer Advisory Board tartlied in a
review of the multimillion dollar Virus
Cancer Program (VCP) that was not
exactly complimentary.
Edwards's remark won him as many
friends as it did adversaries. Right from
the start, many, many scientists op-
posed the administrative scheme that
set the Natidnal Cancer Institute (NCI),
which is running the war, apart from
the rest of the National Institutes of
Health. But the National Cancer Act
of 1971 was passed just the same, and
the guestiod+ of whether that ever
should--have happened became sub-
merged as cohtroversies arose over de-
tails about how the cancer crusade
should be staged. So, a lot of people,
including sonie' membets of the cancer
board itself, were happy to see Ed-
wards resutrect what they consider still
to be the basic issue.
The catch Is that, were Edwards to
have his way by withdrawing the NCI's
special status within NIH and cutting
it down to size, It does not necessarily
follow that future decisions about the
level and style of support of cancer
research would revert to the scientific
community. Nor does it logicaliv fol-
low that less money for cancer would
mean more for anyone else. What does
follow is that scientific decision-making
would become even more oetttralized
within the Administration ahan it is
now ( Srienre. 2 November).
i
often the case with amateur's machines,
were not absolutely eiean. Pieces of
gunk accumulating on the erase head
can sometimes lift the tape away from
the erasing signal and leave a thin strip
of unerased material on the tape. The
.. 1... .....,01:.,.A o7n,wlv hv-n 6nP.
iag the tape with a solution of car-
bonyl iron partieles, which settle only
oti the strip of tape that has remained
ma¢netized. Also, tape recordittgs grow
stronger with age as the magnetic pat-
tefin recruits new particles that are more
resistant to erasure. The tape of 20 July,
1972, erased on I October 1973, may be
jutt old enough to ahow this effect.
Third, if the erase head were misaligned,
it may have left an unerased fringe.
Lisrty ^f he tess fcr tampering
described by Blesser and other experts
are statistical in nature, which means
that, unlesi some particularly crude
forgery has been perpetrated, the panel
may only be able to give probabilistic
conclusions. And exhaustive tests of all
seven reels of tape could take a long
'time-S man-years according to one
estimate. One way or another, Sirica's
court will be lucky if it reeeives any
quick or definitive answers from its
panel.-NtcHOt.es WAne
The strongest exception to Edwards's
charge that the cancer program is ann
administrative mistake has come from
investment banker Benno C. Schmidt.
who is President Nixon's principal ad-
viser on' the cancer crosade. °iDesj+ite
expressions to the contrary by the as-'
sistant secretary for health, it is my
opinion that the National Cancer Act
of 1971 is a sound piere of legislation
that has worked exttemely weB " he
told a crowd of physicians atteadiog
the National Conference on Virology
and Immunology in Human Cantxr,
held reoently, in N'ew York. The mis-
takes that have been anade, in his
opinion, should be blemed on the Ad-
mipistration, not the cancer itgisllation.
Schmidt thinks it was a mistake for the
Administration to cut teseat+dt ttwiniog
grants and to reduce funds for other
areas of researoh at a tirne whm.ptFo-
gress in cancer depends alwa Vrogrtss
in other aueas as well. "At 1ha, time
we wote nrging on Caatl¢e:a amd the
Administration a stater e1111o/t..ia can-
cer, we wrre very ettpticit 1o+lda,posi-
tion thai the ittt:raaeed ottnca3: z$on
tthould niH ite ,t~ter
~I~
r~
l ant Lelieret 3hat
that
fo

frequency, a feature known as the start
transient. The start transients will be
present on the original tape but not on
any rerecording, because the bias fre-
nnencv is toe% h;gh to be reproduced
by conventional playback heads.
The White House tape recorder a
Sony 800B-may have left other dis-
tinguishing marks on the tape besides
UlC Ola! IIC{tuC11Cy. VI/C 1! 111C illlglt Ol
the recording head to the tape; any
shift from the vertical can be measured -
by a reduction In the efficiency of the
recording. Another measurable feature
is the degree of wear on the recording
bead (or, more precisely, the diference
in WPAr between the too and bottom
halves of the head). The wow and itut-
ter, caused by imperfections in the cap-
stan, are also a characteristic of each
machine. Though none of -these features
by itself is definitive, together they
should serve to fingerprint the White
House machine beyond any reasonable
doubt.
Unfortunately the particular speed at
which the White House recorder was
played may put the bias frequency
studies suggested by Blesser at or even
beyond the limits of present technology.
To pick up the, bias requires a play-
back head with n gap between its mag-
netic poles which is no wider than
the frequency wavelength. The Sony
SOOB has a bias frequency of 55,000
cycles per second and was played at
a_speed of 15/16ths of en inch per
second, giving a wavelength of 17
microinches. The smallest gap avail-
able in commercially produced heads is
60 tnicroinches. Even with a custom-
built head, the minute separation caused
-. simply by the surface finishes on the
recording head and the tape might have
prevented the bias frequency from be-
ittg recorded in a recoverable way.
If the bias frequency cannot be re-
covered, it may' be possible to use otbe,c
periodicities on the tape instead, such
as the 60-cycle-per-second bum of
alternating current.
Another approach outlined by
Blesser is to look at the acoustics in
which the recording was made. Ac- I
cording to the White House, some of I,
the microphones were concealed in
desk drewers. A desk drawer will act
like a sound box, with a paiticular
dominant resonance that can be identi-
fied from the tape recording. If any
rerecording had been made with the
mike outside the drawer or even in a
different position in the drawer, there
would probably be a noticeable dis-
continuity in the energy pattern of
sounds recorded on ¢he tape. The ex-
pen placed on the panel to study this
possibility Is Thomas, Stockham of the
University of Utah. 5tockham has de-
veloped a computer program for im-
proving old t:aruso iecormngs oy sutr'-
tracting the undesirable ticaustic
qualities of the horn Caruso sang into;
The same method should be capable of
A third )Cind of teat for editing, aa.
cording to Blesser, is analysis of vari-
ous speech factors. One such factor is
the intonation pattern that rises and
falls continuoutly throughout a sen-
tence. lFACision ~.i insertion of a phrase
wu, piudu..4 an in the pattern. Another a»omaly caused
by trying to edit the continuoras stream
of human speech can be detected by
~-^-
. prints. Most speech sounds ato eom-
SIPI Appeals for Aid to Vietnam
37te 8cientistt:` Iaatiqtte fot cuolie ILtwmatlon '=j has ttwrtel a
drive to mobilize the raources of the American sdenti5c comrtiunity
to aid' in the recovery of war-damaged Indochina. Scientific Aid to
Indochina (SAI). a task fom established by SIPI, plans to determine
what scientific and technological help is needed by the peoples of
Indochina to restore their agricultural lands and to help supply it
throug4t voluntary contributions of time, equipment, and money by
scientists.
Arthur W. Galston, professor of b?ology at Yale University and ;4APs
chairnian, said that the first ptoject of the task force will be to estAbJish
a small Research Institute of Agricultural Botany in North Vietoaan iti
response to a direct request from the North Vietnamese governoaent.
The institute is expected to bd staffed by 25 to 30 scaeatists and a dsnm-
ber of technicians. The govornment of South Vietnam has made no
such request, but in the event that they do, Barry Commoner, chairman
of the board of directors of SIPI, says that SAI,would make every effon
to provide similar help thera.
- The Research-institute of Agricultural -Botang is of first priffity be- .
cause of the dspendence of the Vietnamese people on agriculture. The
destructioa of agricultural lands by U.S. eatlbmovers, bombs, herbikidea,
and other weapons calls for advanced techniques In repairing the hmd
I and niaking. it productive again. Existing agricultural retearcb labora-
tories tvere destroyed during the war, according to the 3AL
I Senator Gaylord Nelson (D-Wis.), who has Introduced an Ecoliagical
Damage Assessment bill to determine the long-term eoolollical effects
of the war, is fully in aupport of ehe task force and ifs first project.
The SAI was established last spring to infortn American citbedss of
the extent of htttaan and ewlogical damage in Indochios and wlaat an ,
be done to ropair it. Its first project was developed after two of its
ntembers, E. W. Pfeiffer, professor of zoology at the University of
Montaaa, and Arthur H. Westing, professor of botany at Wintlham
College, returned from a tour of North Vietnam last aummer. They
told of massive bomb craters and large areas of dtsvastatxd farm land
After Pfeiffer and Wasting had ditcussed the situation with the Sate
Committee for Science and Technique of North Vietnam and thr Soo-
ciety for the Dissemination of Scientx and Techoique, SIPI'a counterpart
in North Vietnam, SAl adopted ghe research itustitute as its 6rst ptohct.
The letter of appeal front SIPi, signed by Commoner and Cia;aton,
has been sent to more than 10,000 scietttieb. At:oordiog to laatstod, the
project will have no connection with any gavernment-ralated effort Gal-.
ston likens the voluntary participation of U.S. scientists In this roeattote to
"an act of personal restituNoa for war datrtage." The immediate gbal is
to raisC $100.000 by eaily 1974 so-thatfiabton can travd to Nortb Vk.t ,
ttam ia the spring to tstabifab tW instiate.-Booits, jotz,-.ris, aad cVIp" _
ment um also needed, as well as eeientisss to train the ImNtute
~.,
t
Prospective contributors may contact SAl at 36 Eait 68 Smeet, Ns,FT
_ . ..r..°j/~f`~:* ' ~
9742
M hcrpLlnFit f9t3

W
I
testified. Several of them were aske4
for their views about doing research
by contract rather than by grant. In
addition, the committee apparently eon-
sidered the issue repeatedly as it evalti-
ated the VCP through various routes
durine the course of its investigatiotd.
Most of the members of the committee
do research by grant, rather than by
conuac4 and their feeling that this is
the right way to conduct research is
apparent. One gets me impression uidt
the committee is sympathetic to the use
of contracts to procure specific services
or materials. It makes sense, for in
stance, to contract with someone to pro-
duce viruses, run certain standardized
tests, obtain human biopsy material, and
so forth. But scientists supported by
VCP contracts are also doing a large
amount of what can only be called
basic research in the strictest sense.
' The Zinder committee seems to have
two objections to this. One is simply
that such studies should be done by
grant. The other is that because the
review of contracts is, in its vieW, not
as rigorous as the review of grant ap- -
plications by NIH study aections, a Iot
of mediocre contract work is being
supported at what ' may be the expense
of grant research.
There really are two issues. Should
all basic research be done exclusively
by grants? It is a question the biomedi-
eal community_ has been fixated on for
quite a while. Some people say yes.
Others, emphatically no. It is not ap-
parent why there has to be an ttither-or
answer, but there are very fev; people
who really believe that there is room
for both. Most of those who do are
scientists who used to work oh grants
ahtd now have contract support.
Jh0ut0 rnWjOcre wutis, wO~r uw.
would be turned down as a graiat appli-
cation, be supported, sometimes virtual-
ly indefinitely, by contract? Obviously
not, anu i7mc a.+u.r- ui u.r ::.:.:.."..u."'....~..."
tions of the Zinder committee surely
have a place. Scientists should,not, for
example, sit in the room when their own
contracts come up for epptovaL Nor,
for that maner, should members of one
review group have control over the oon-
ttacts of another member. (VCP scien-
tasts say tbis procedure will be avoided
under aeKly instituted regulations.) The
clincher, which may be legally impossi-
tvle for the NCI to implement, even
vbere it to want to, is a recommendation
to clean house and start all ovbr again.
'All contractors should be notified that
their contracts will be terminated over
the next 3 years."
According to Rauscher, who was re-
sponsible for cjosing the portion of the
board meeting at which the Ziader re-
port was discussed, the board gave it
mixed reviews. (Among the members
of the board, it should be noted, are
persons funded by the VCP, persons
known to be antipathetic toward it, and
persons in between.) There' was some
Nuclear Safeguards:
Holes in the Fence
Stealing a warm silvery lump of plu-
tonium and fashioning it into a make-
shift weapon is a scenario of high-tech
nology terrorism that has fired the
imagination lately of tnulear critics
and Hollywood scriptwriters alike. The
Atomic Energy Commission (AEC)
acknowledges that skilled technicians
could assemble a crude weapon from
stolen plutonium or highly enriched
uranium. But is It really plausible to
tuab off with a critical mass or two?
Jf a new inveatigative teport by the
C3eneral Aceolmting, Office (GAO) Is
any indicatiote, the short answer Is
Yes. The ABC teaOy agnees that in-
b:ntives exist- for aealing fissionable
anaterial, and that losses have occurted
(Science, 9 April 1971), but it stead
fastly malfitains that it is unaware of
any actual theft. If the AEC'a t+~ecord_
really Is nnblettdshed, though, the
.norypw shat a thief could penetrate (iAO'a report suggests it may be more
the security Imposed by the AEC on - by virtuf af Itdck than v$gltatux.
"special nuclear materials," as It calls The GAO's investig®tion, began in
the fissionable metals, and could he the summer of 1972 and centered on 3
till
feeling, be says, that the report focused
too much on the contract vetr8rs graht
issue. Others felt it failed to ttwcognirs
some of the very real achievements of
VCP scientists, achievement wh}ch they
believe ean be attributed to the fact that
the resources, of the program and the
.........», a » : ».,.-. _.......f; e-y:-
offer something grant tesearch does not.
Others felt the report was 6ne.
Zinder prefers not to coatment in de-
sCl r..ne,.e- t-
f..le nl.lins/.A Vn rnAtM-
tain the confidentiality of the board
and the NCI, although he says be would
have been willing to present the report
in open session. He will say, however,
that he and the oonunittee etand behind
the report and that it was issukd with-
out a single niinority opinion. ,
Tedaui.,aiiy, the+."cer twsd'has not
yet officially received the report atYd
may not do so until iu next meeting-
in Mareh. Meanwhiler disqt5sian of de-
tails of the seport will continue through
a eommittee of the board, a committee
of the Zinder oolmnittee, and a codo-
mittee of the VCP staff.
Whatever finally happens to the VCP.
there are members of the board who
say that the Zinder committee report
must not simply be accepted and then
shelved. Their intention is to see that
it is not, which it:iparticularly importtint
at a time when the' AdministRation is
putting pressure on the scientific coan-
munity to do more t:aearch, by cdn-
tract-not le.cs.-BattBettA f. CttLr.rnsrw
of nearly 100 organizations that possk'ss
nuclear materials of "high strategic im-
portanoe' mder oontraets or lioeuees
granted by the AEC None of the
three companies ii ideatf8ed ih the re-
port, althatrgh It ae learned that at
least one praoates - bighly enricLed
uranium near Oak Ridge, Tmnessee:
At each of the three pant&, tnve,tti-
gatora fottnd. ftssionable ataterial stored
in portable containers about tlre ttt:e
of small coffee eans. -The eontainers
were kept in sheet4teel or ciawderblock
storage sheds surrounded by fences,
wired with alamu, watched by guards,
and protected by loohs.
Nevertheiess, t6o GAO fouad that
at two of the plants-descn'bed only as
"Lsoensoa A" and `T.ioensee B"---ane
matt equdpped with an adjurtable poeOtet
wrench and a etrottgatm could bsedcls
these harriets and lay his' huads, unde-
tecfed, on ade pottabfe Aattainers in a
matter of mioutei i.ocki erone AD"d
ttnfoaked, aeaft ware ba+akea; 41iLrms
~'LN ~ 18724
