Tobacco Documents Online

~f _.SF0310030 ~ ~~~; ~.._ Chronic Exposure of Mice to Cigarette 9noke i Final Report of Research Perfouned under Contract Entitled "Smohe Inhalatiaon Studies in Mice" betraegn Microbiological Associates, 8ether,da, Maxyland and the Coiuicil for 7bbaoco ResearcU,S.A., Inc. Nflw York, NY "I Contract ApArwed bY the Scientific Advisary Board, Gbuncil for Zbbacco Research I Field, Rich 4 Associates, Inc. New York, NY 1984

Sr0,.4 100 37 A01 51A.Q ap--) --- FORIMM ..~c 5W OP we material that follaws is the oaaplete and unedited final report of contract research perforared f.resn 1975 to 1983 by Micrabi;.iog: ;a_ Associates ' ,Be*hesda, MD, under the auspices of the Scienti3_c Advisory Board to the Oatu:cil for Zbtaco Research - U.S.A., Inc. L-:e expe+N++e*+ts represented a detennined effort to develop a suitable an.ima' model involving chronic cigarette siroke exposure of inbred mpuse s-ars known to develop vatcious histopathologic types of lung carcinrma a=.er intretracheal. ar~„in+ar+~tion of pure c,heinical carcinogens. It is :eLe:mc the report will be of interest to those engaged in inhalation research and in the field of investigating htman groking and health relatic_.stii_rs, 7he results observed included these: none off the smake-exposed 3nim' e developed pulmenary squamcus cell carcinomas mice pretreated with a pure carcinogen did aot have aiqnifieantly increased lung cancers after gro- lbnqed mmoke exposurp; and the overall rnmbers of pulmonaiy neoplass identified were not statistically significantly different in the smce- exposed mice, eaqxazW to the st:am smoke-exposed or shelf control miee. 5heldon C. Sune3rs, NID ScientYf ic Director, Qou=ill for Tbbaooo Research - U.S.A., znc. 1 . ~