Council for Tobacco Research
Lack of Effect of Exposure to Whole Cigarette Smoke on Oocyte Depletion in Bc3f1/Cum Mice [Status of Publications.]
Abstract
MAR
Fields
- Type
- SCIENTIFIC REPORT
- ABSTRACT
- Depository Date
- 31 Jan 1996
- Request
- 132
- Master ID
- 300200550-0634
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- Site
- Hoyt
- Box
- 098
- Author
- Mattison, D.
- Kanagalingam, K.K.
- Avery, M.D.
- Felton, J.
- Kouri, R.E.
- Henry, C.J.
- Kanagalingam, K.K.
- Brand
- 2r1
- Z00000, Reference Brands
- UCSF Legacy ID
- tqd1aa00
Document Images
NT®0121 104
4. Atresia
Title: LACK OF EFFECT OF EXPOSURE TO WHOLE
CIGARETTE SMOKE ON OOCYTE DEPLETION IN
BC3F1/CUM MICE
Authors: D. Mattison, K.K. Kanagalingain, M.D.
Avery, J. Felton, R.E. Kouri, and C.J.
Henry
SUMMARY
The number of oocytes was determined in ovarian tissue
from BC3F1/Cum mice after exposure to 2R1 cigarette smoke. Age-
matched animals, treated exactly as the smoke-exposed groups but
sham-exposed without cigarette smoke, were also evaluated,. Smoke
and sham exposures were initiated when the animals were 8 weeks
old and continued 5 days per week for over 50 weeks. The number
of oocytes per ovary in untreated BC3F1/Cum mice at "8 weeks of
age is -4300. This number gradually declines as the animals age,
reaching -200 oocytes per ovary by 40-50 weeks of age. Exposure
to the smoke from five 2R1 cigarettes per day (-400-500 ug total
particulate matter per lung) resulted in no significant differ-
ences in the number of oocytes per ovary between the smoke and
sham exposed groups, compared to untreated controls, over the
observation period of 8-50 weeks of age.
Status: First draft scheduled for 11/81.
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