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micr®biotogical Associates Mge® nly Model 1nhalation Syste.

............... .... . ...... -T-• • . - ia~'".. .. • ' . . . 0.GG Ht801 2C . . . NowaVdnank ® ® ®' :;.•. . . _ . r1 ? :~®i~~ - r' f~~i' dobiolourica , _..Y~-;• ~ . s5®C~~ tes _ ~.~,. . . a~ Located in 8ethesda, Maryland. Microbiological •: __ • Exposure to environmental -- Associates (MA) has for over 25 years provided aerosols either alone or in com• the highest quality scientific and technical ex- bination with cigarette smoke. pertiseto meet the research and testing needs of . Safety and efficacy of phar ;'r: •'ft' the Federal Government and industrial clients -'" ' maceuticat aerosol products ~- . . y~ • . . . .: .: . : . c. :iz - around the world. In the course of developing a: =, Evaluation of tobacco additives in cigarene ~~ model system for studying lung cancer and the smoke. J ,. .. :• The Nose-Only Model Inhalation System can be adapted for studies employing nebulizer- generated or dust-generaled aerosols, including:. ~ k' J. r= r ® Fumes ' • Chemicals and mixtures r - • Cigarette smoke. ~~ Gases~_~; ~ a Pre-and Post- combustion products 7a•' -' ~ Unique Method of Restraint ;. The Nose-Only Model Inhalation System at MA uses a unique method of restraint during animal ~ exposures. The animals are held in stock-like ~ k t i i i i h e ot and r ng spr ng. ' holders w t a nec stra n s A chin rest ensures that the nose of the animal ~ is aligned with the conical-shaped opening of -_ the exposure module. The nose of each animal '' protrudes through a dental rubber-dam dia- . phragm which forms a s9at to prevent body~" ' • ~ ,. ~., exposure. When adequate air and/or aerosol is effects of exposure to whole cigarette smoke, provided to the exposure module, animals may c a new and unique system has been designed in % be restrained up to three hours, twice daily, . our laboratories for conducting pulmonary toxi-: without mortality or iII effects. oologyandcarcinogeniciystudiesbynose-only Sok inhalation exeriment can beon- ; :• rneaon.sose-nyoenaaon: ' ihlN Thi NOl Mdl Ihlti ith ith f t t k t d d im er o wo ypes o smo uc w e e e System Is now available for a variety of toxico= hi l r i n mi ti d - nes: a ge capac ty ng mac a y a c : = logicalapplicationswherenose-onlypulmonary .;_ genera l ti Srnok re M hin (SEM II) E oma xposu au c e ac e ;?_ ;: n r irabl rosols i ired t s a d ss exposu p o e e e s es . .. .3 , . ; .-... ~. _r , . __ ,,. in which smcke is routed through the animal . _ ~` ~ ~ntainment unit as a ccntinuously ftowing = - ~r - 4 14 ~iCdtlanS: ~° • ;~~.- PP stream; or a small capacity static exposure ~~ . . A unique system to help in the evaluation of. '• .. systerts, the Walton Horizontal Smoking Machine, "• Exposure to occupational aerosols, eith0 ~ in which smoke is introduced to exposure • '-.` alone or In combinaton with cigarette smoke. chambers into which lhe animals respire directly. r:y. ... Particulate deposition in lung tissue has been shown to be the t,tv same for animals exposed to smoke : Y~ * C 4 from either machine (1, 2). ~ t ..~s . ~..~ ,• ct yr: ... -~= medic; to ollc• '°r", followl

L mm '; ~- L uy : :; ' F . : Y1-.!5~~.4er.;~ _+ Y _T.r • .... .. ~,..: ; ,S Wide Range of studiesarecond'uct- ed with strict internai S4UdieS i securiry to assure . AtMA,ourmanyyeaconfidentiality. MA's ... :_ of toxicology and bio-t =. comprehensive com-, . medical research experience make it possible •`:"• puterized data processing services pro'vide full to offer a wide range of toxicological end points~ ,. histories and back-up information on all tests ;.`1'.;' :' _ following nose-onty inhalation exposures: performed~• -- _~~~ =.ta•f~ ' • Acute and Subchronic Toxicity'-~ i• .. • Pharmacokinetics and Dosimetry~~:~: yA • Metabolism Jet • Biochemistry:_ „4 • Imrnunotoxicily • Clinical Chemistry - - ~ ~' - • Chronic Two-Year Toxicity • Chronic Two-Year or Lifetime Carcinogenicity The Nose-Only Model Inhalation System at MA occupies a modem 8,000squat"efoottoxicology facility designed and operated to ensure that the health of all animals in the facility is neverr-:i compromised. Animals are screened by our owri •• ' Our laboratory facilities and Quality Assurarice : ;:' - Systems are open for your exa mination to verity~: : that the studies performed and data generated are of the highest c;aliber. ;-•• To arrange a site visit of the Nose-Only Modei Inhalation System or for further information on - toxicology testing available at MA, ptease con;'__::'.~ tact our Marketing Representative at (301) 654-3400. %; References°~ / ~ e I.Henry,C.J..Whitmire,C E.,Lopez.A.•Dansie.DR.,Av ry, ' M D• Caton. J E., Stokely. J.R.. Holmoag. R.w.• Guerin,,: ::~. '- M.R., and Kouri• R E. The Dosimetry nnd Distrbulion of Whole Cigarette Smoke Particulates in Inbred Stra.ns of ,~ f ~: Mice: Compansonol a Large Smoke-Exposure Machine •_::. ~_~ Animal Disease Diagnostic Testing Laboratory. fSEM) Yvlth a Snlail-Gapacny Smoke•Exposure Machine,•s:~1~ },.,I P~ to ensure and document that they are disease ~ r. :(walron). te: Pulmonary loxicalogy d Respirable Parncle9 ~= :~.; -~ V J - free. C.lSanders,F.T.Cross,G.E.DagleandJAMahalleyt@ds.L,~Nt:.~ - j; V TeChnxal InlorrrbtbnCenter US Da arUnant f Ener gy p o ,...q~~ y QaJ6~,1~ I-VSU/6l/ /t~. ProC~GYiVreS t~tt1.S. ~9aD. a..a: : i: 7F1C(.~,~1'Y~- '' q~ ;~~p ~ 2.Henry.CJ..Ceton J.E 5tatcelyJ R Guerin M R Lopet ~e; • , . , . ., , Ali tests at MA are monitored by our Reguiatory.- :' A, Avery. M t) , Danaie. D.R., Handerson, G.M.. Gayle, T;6~~ D C E K d R Ri ~ O E ' ~ ~ ., arq . ou , . on +rw epra istr bullont:~a~ Affairs/Q1,Jality Assurance Unit to ensure that they = u• ' ~' . of the Total Rartioulate Matter of C' rene Smoke in Micei=-r v' are pe ormed in ac- Using a Large Capacity Smoke Exposure Machine. Tod-; ~•:' ~'= cordance with the Good _ cologyand Appked Pharm. pn press) 1981. , _ . . . . _ :~....,,'~:~.. rnuuleuveyFraGUG@S Regulations of the FDA and EPA. In addition. all .*.` ~p .~ f11Yr1I_~Y Ii/ - %%rh ka ~~ A Unit of Whittaker Corporation 5221 River Road Bethesda, MD 20016 (301)654•3400 The difference is Microbiological! i

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