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_~----~.- ._.---- Micrab9ological AsN 5221 RIVER ROAD s gETHESDA, MA6YLAtJD 20016 TELEPHON E: (301) 6'64-3400 April 14, 1981 Dr. Thomas S. Osdene Philip Morris, U.S.A. P.O. Box 26583 Richmond, VA 23261 Dear Dr. Osdene: For the past eight years, Microbiological Associates ("IA) has been privileged to be the prime contractor for the development, implementa- tion, and characterization of a model, pulmonary toxicology bioassay designed to study the effects of exposure to whole cigarette smoke. 1 As a result of this program, MA has evolved its Nose-Only Model Inhala- tion System specifically designed for conducting studies by which I rodents are exposed to aerosolized materials via anly the nasal orifice. MA is now in a position to offer th;s "state of the art" approach to inhalation toxicology for a variety of toxicological applications where pulmonary exposure to aerosols such as cigarette smoke, chemicals, fumes, and gases, or com66inations of these materials is desired. aA has developed the specialized equipment necessary for the generation, delivery, and monitoring of a wide variety of aerosolized materials - including whole cigarette smoke - as well as developing an effective and safe animal containment system to facilitate nose-only exposures to these aerosols. We have also developed and characterized an animal model system for pulmonary carcinogenesis and have been able to institute a comprehensive animal disease laboratory to preclude the utilization of animals that may be affected by possibly adventitious disease agents, and to prevent the introduction of such agents into our facility. The enclosed brochure highlights many of the Nose-Only Model•Inhalation System's applications to identifying and chacacterizing potentially hazardous substances and to understanding the human health implications of these compouzds. I have also enclosed a Capabilities Statement which not only illustrates the wide variety of capabilities :o which the :Vose- Only Model Inhalation system may be put, but details previous studies already performed with this system at MA. A.Gi~ 6 T81 A IINIT OF W3331tta116K-0a'

~ _~ .._ _ . . ' HTi0120004 Page 2 We feel MA's background in the area of nose-only inhalation toxi- cology enables us to address many of the existing problems in inhalation toxicology at a Ievel of understanding which was unattainble in the past. We feel this Nose-On1y Model Inhalation System holds great poten- tial for the future. If you have any questions regarding MA's Nose-Only Model Inhalation System, please do not hesitate to call me at (301) 654-3400. If you or any of your colleagues plan to visit the Washington, D.C. area, please let me know, and I will be glad to arrange a site visit of our facilities. Sincerely yours, Andrew M. Losikoff Marketing Representative nM4,/3 km