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7'ru: ('w•.c•Ir. F()rr Te»3m•c•() Ix(•. )pl' it"C~~ M 0,22550os July 7, 1977 Grant Arrolication r:o. 104k'R2 PULI•~O::F!iY T0: The conmittee compriting Drs. Gardner, Jacobson, Lynch and Wyatt SUBJLCT: A. Sonia Buist, i•:.D., University of Oregon, School of N.edicine, Portland, Oregon Second renewal applica:tion No. 1044R2 '•The role of alT)hal antitrypsin deficiency as a risk factor in the development of chronic airways obstruction'• HI S'?'ORY In September 1975 the SAB approved a t;-iree year project at a first year level of 324,735.00 (as rec_uested). Estimates for the second 2nd third years were approximately ~25,000.00 and C2128,000.00, respectively. The second year of the project (1104+R1) was fUnded at a level of $26,557.00, as reauested. REGU'ST Application No. l0'•-4a2 reo_uestN 530,358.00 for the third year of the project. (6:2,690.00 is a.ilo~tted for permEnent e(luiroment). DCCUrW;:TS SUM:-:ITTc.D (ettached )a 1. Application dated. June 21, 1977 (11 pages) 2. Progress Report i:o. 2 for the period July 1, 1976 through June 30, 1977 (14 pages including face sheet and Figures and Tables) 3. Reprints (1 in number )- nd C'I91 acknowledgement ) C01'1;: 1' As progress appears to be satisfactory, this reouest will be handled administratively and withheld from the bizlky SAB agenda for the October meeting, unless you object. David Stone DS/ah Encls.