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`rIII: COL'1CIL 1'Un TOISACCO RESL•'.XI2CII-U.5.11., INC. Fehruary 23, 1977 MEMORANDUM H KR "??`.:S 4 6 i S TO: Drs. Craighead, Feldman, Hockett, Jacobson, Sommers and Stone FROM: W. U. Gardner SUBJECT: Supplement to Memorndum of January 18, 1977. Application 1127. Herbert Y. Reynolds, M.D., Yale University School of Medicine, New Haven, Connecticut. "Bronchoalviolar Lavage Fluid in Pulmonary Carcinoma: Secretory Component of Immhnoglubulin A as a Marker of Neoplastic Growth." On February 21, 1977, I met Dr. Herbert Reynolds. We spoke of the significance of IgA in the lung. He mentioned work of the upper respiratory tract, trachea ar.d the larger bronchi, but stated that not much was known about the production of secretory component in the peripheral lung. it was probably more likely to be effective against viral invasi_ons than bacteria or fungal SC is higher in smokers than in nonsmokers. These will serve as sottrces of SC (sputimt). Some individuals have a rather high production. Saliva was found to contain about 214 ± 65 ng/ml. Apparently it is not an easy antigen to work with but there are enough species difference so that it can be done. He has a well-equipped laboratory, recently completely renovated and had one young assistan*t working in it. He was familiar with the work of Michael Lamb and that of a number of IgA investigators. He was vague about the lysomal enzymes that he would study but mentioned the a-1-pi phenotypes, transferin and albumen as a reference. He seemed to be a dynamic person. W.u.G. PNG : ei: