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7Ci[I: CO[;1CIL FUH'1I (J13.1CC0 I;L:SEAItCII-L.S..L., INc. HKW 1*2 ") ", -11 3 S 3 I JanAiary 25, 1977 I Grant Application flo. 1138 PHARM.ACOLOGY C o A fi1h v a t/AA T0: The committee comorising Drs. Bing, Gardner and Jacobson York BUBJECT: Walter B. Essman, Ph.D., M.D., Queens College, Flushing, New New Application :2o. 1138 "Correlat'es of Stress - Tobacco Smoke interactions" HISTOR Y Dr. EssmaM has been supported by CTR since 1968. Grardts 623, 623A and 623B (1968-1972) supported investigations on "Study of Nicotine Action in t:emory Consolidation". Grant *Io. 836 was awarded in September 1971 for a one year period to undertake studies on "t'ptabolic Response to St'ress...Tobacco Shoke Inter- actions". A Continuation application (?io. 836A) of the same title was approved by the SAB in September 1972 for a three year period. In September 1975 the SAB approved Continuation application (836B), of the same title, at a first year (January 1, 1976-December 31, 1976) level of $61,254 ($7:1,274, requested). The secohd year (Application No. 836BR1) was denied by the 3AB in Sept./Oct. 1976, on the basis that the studies were not sufficiently targeted. However, a supplementel Grant (No. 83655) in the amount of $30,000 was awarded in December 1976 for the period January 1, 1977- June 30, 1977. REQUEST New Application No. 1138 requests $67,262 fo° the first year of a three year project• Estimates for the second and third years are ,570,441 and $73,810, respectively. DOCt1MENTS SMITTTED: (attached) 1. Application dated December 30, 1976 (27 pages-Budget pages are pages 25/26...nq numbering). 2. Progress Report Ito. 6 covering period January 1976-December 1976 (33 pages, including Fnce-Sheetti ri,^ires/Tnbl~e). 3. Two reprints (1 ac:cnowledges CTR). 4. Three manuscripts in press (1 acknowledges CTR). David Stone 0 DS/ah

Tin: Cor-Ncn. Toli ToBncco RrsEaxc1s-L`.S.A.. INc. Application No. 1138 ESSMAN coWnrr HK0 221 ti738 4 Pg.2 Part of this study will involve a collaborative effort with Drs. 'Whitmire and Kouri at Microbiological Associates. D.S. f