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, HK0222345f; AGENDA I:ORKSHOP on CHEI•10PREVEI;TIO!; OF CAtJCER l:ationa•Y institvt,~s of ticalth Bui?d.'ng 31 Thursday and Friday February 2 and 3, 1978 Sponsored by Carcinooenesis Research Program Division of Cancer Cause and Prevention Uational Cancer Institute

Thursday, February 2 Part 2 - Inhibition of Carcinocen Activation and Binding to Ce1lulAr Tergets, continued H K02223058 Effects of Dietary Fat and AntioxidarAs on 2:20 - 2:40 Dh13A-induced htar::T,ary 1Jeopl asia Paul McCay, Oklahor,a Medical Research Foundation 1•fechanistic Studies on BHT Inhibition of Che.nical 2:40 - 3:00 Carcinogenesis Elizabeth K. Weisburger, National Cancer Institute Suppression of Ultraviolet Light Carcinogenesis 3:00 - 3:20 by Antioxidants Homer S. Black, Baylor College of Medicine General Discussion 3:20 - 3:3b Coffee Break 3:30 - 3:50 Disulfiram and Related Compounds Inhibition of Metabolism of Colon Carcinogenesis 3:50 - 4:10 by Disulfiram and Related Compounds Emerich Fiala, As,erican Health Foundation Studies on thei,echanism of Inhibition of Benzo(a)pyrene-induced Foresto.,ach t;eoplasia by Disulfiram Peter Borchert, University of iSinnesota Selenium and Its Salts 4:10 - 4:30 Selenium Modulation of Carcinogenesis 4:30 - 4:50 A. Clark Griffin, P1. D. Anderson Hospital Trace Elercnts and i;utritional Factors in Cancer 4:50 - 5:10 Prevention Gerhard N. Schrauzer, University of California - San Diego General Discussion 5:10 - 5:30

v~.:,-...-.:...._._ .. HK0222.30GG Fridav_, FebruarL _3 Fart 3 - Irihibitien of Framot;on and Procression Chairman: Michael B. Sporn, t;ational Cancer Institute Preventiord of Epithelial Cancer by Retinoids 10:30 - 11:00 Michael B. Sporn, t:ational Cancer Institute Inhibition of riumor Promotor-induced Ornithine 11:00 - 11:30 Decarboxylase Activity by Retinoids R. K. Bouta:ell, University of !•:isconsin Interaction of Retinoids and Phorbol Esters in 11:30 - Noon Lyr.:phocyte t•ti togenesi s Gerald C. 1-'ueller, University of Wisconsin Suppressed Progression of t1arl,aary Carcinooenesis i;oon - 12:20 by P.etinoids Richard C. i•foon, IIT Research Institute Part 4 - Chcr.,onre•,:ent_on Sn H`an Risk 'r.'un.-n Fovalat_ons Chain:ran: Jerome J. DeCosse, t•Sedical Colleoe of l:'isconsin Ascorbic Acid and frevcntion of Large Bo-,:el Polyps 1:30 - 2:10 Jerome J. DeCosse, fedical College of :•:;sconsin Retinoids and Prevention of Bladder Cancer 2:10 - 2:50 ;:a:^ren 1•:. Koontz, Jr., h;edical College of Virginia Anticarcinogenesis with 13-cis-Retinoic Acid in 2:50 - 3:30 Prevention of Lung Cancer ` Cordon Zubrod, Oleg Selawry, La:•:rence Eroder, and Peter M.ansell, University of Miami School of Idedicine

N1022230sq Friday, Ftbruary 3 Paxt 2 - Inh_hition of C4rcinoacn Activ~`-~on ,end Hinding l:o ccilulax 7aructs, cor.rinuea ~ Characteristics of i•iicros©mal tlixed Function Oxidase Activity_ Alterira Carcir,n~cen I' ~bol isn Introduction Lee W. 1•!attenberg, University of 1linnesota Regio- and Stereospecificity of Cytochro,•^e P-450's in 'Denzo(a)pyrene t.ietabolism J. Deutsch, t:ational Cancer Institute Different i;etaholic Profiles of Polycyclic Aromatic Hydrocarbons in Inbred Strains of tSice Irene ..;ang, Fkdical University of South Carolina Properties and SNecificity of Systerls 9:05 - 9:25 in I'etz.bolis;a of Ch_..ica1 Carcino,--ns Alex t,ood, Hoffc,ann-La Roche Inc. Activating ;'.-tabolism of I;itrosa.:iries: i:aturc and 9?5 - 9:45 and tiultiplicity of i;ixzd-Function Oxidase -P&th;tioys - A Sui.'„ary - Joseph Arcos, Tulane University General Discussion 9:45 - 10:10 Discussants: Allan Conney, Hoffr,ann-La Roche Inc.; Harry Gelboin, hational Cancer Institute; tJilliam Hoekstra, University of l•;isconsin; Anthony Lu, Hoffmann-La Foche Inc. [ Coffee Break 10:10 - 10:30

: ThursdayT Februa_a 2 HK112223057 Introduci.ory F.cmarks: Arthur C. Upton, 8:15 - 8:30 Ilational Cancer Institute Fart 1- InhJ:bStion of Formation of CaICInoD,'ns Chairman: John H. 1•:eisburger, Ar„erican Health Foundation Prevention of Nitrosamine Formation By Ascorbic Acid 8:30 - 9:15 and 0tiier Reoucing Agents, in vitro and in vivo Sidney h1irvish, University of Nebraska Food Processing and Composition with Respect to Cancer 9:15 - 10:00 Johri H. l•:eisburger, American Health Focndation Coffee Break 10:00 - 10:20 Ilodulat.ipn of Levels of Plutagen in Hu;'•an Feces with 10:20 - 11:00 Chl.nces #n Diet Is. Roberi. ,rvice, Ontario Cancer Institu-,e Open Discussion 11:00 - I;oon art 2 - InniLit;on of Ca_rc-:roaorr rc{__:_iicn and ir,c 70 --- -t'o Ce11u?~r -ceLs -- ------ - Chair ian': Lee h'. i'attenbarg, University of ;:i;-.nesota Introduction Lee W. :;aticnberg, University of ilinnesota Phenolic Antioaidants 1:30 - 1:40 Ef~ects of CHA on the tietabolism of Benzo(a)pyrene Luke K. T. Lam, University of 1•ii!inesota 1:4-0 - 2:00 Inhibition of Skin Carcinogcnesis by Antioxic'ants, Flavones, Certain Polycyclic Aromatic Hydrocarbons and TCDD 2:00 - 2:20 Tho-.a s J. Slaaa, Oak Ridge t:ational Iahoratory