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I'vE COUNCIL ~OR TOBACCO RESEARch-U.S.A., INC. January 26, 1978 Grant Application No. 1191 CARDIOVASCUIAR TO: SUBJECT: HISTORY Originally I~ as Principal Investigal The Committee comprising Drs, Bing, Feldman and Wyatt Kenneth K. Wu, M.D., Rush-Presbyterian-St. Lukes Medical Center, Chicago, 111. 60612 New Application No. llgl "In vivo and In vitro effects of nicotine and extracts on platelet function and sialic acid metabolism" ~'~0~(~ l"-~ \ ..... ") with Dr. Booyse For backgroun be considered in the S~ While this Report for the platelet the framework of the Boo tion No. 1191. REQUEST ~SM(A) which will No. 1191. on, the Progress ~rtaken within ~ present applica= Application No. " :at. This applicatio: ~esumably for the second year of th, boyse No. Therefore, no estimate is gSven for the third (and final) year" This will be cleared up by CTR staff. DOCUMENTS SUBMITTED (attached).- i. Application dated November 26, 1977 (page 1-page Ii) 2. Appendix - (Including CVs of Drs. Wu and McKenner and manuscripts and abstracts) 3. Progress Report No. i for period July i, 1977-November 15, 1977 COMMENT The Human Subjects Certificate has been received by CTR. D~vid Stone, Ph.D. CTR MN CG~ETIDENTZRL :" MINNE£:OTFI TOBRC.CO LITIGATION