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CHE COtiTNCIL FOR TOBACCO RESEARCH-U.S.A., INC. '' C44 January 26, 1978 Grant Application No.'1191 H K22 2110 4 g CARDIOVASCI7LAR TO: The Committee comprising Drs. Bing, Feldman and Wyatt SLTBJECT: Kenneth K. Wu, M.D., Rush-Presbyterian-St. Lukes Medical Center, Chicago, 13.1. 60612 New Application No. 1191 "In vivo and In vitro effects of nicotine and extracts on platelet function and sialic acid metabolism" HLSTORY Originally DI as Principal Investigat For backgroun be considered in the SA While this apI Report for the platelet the framework of the Boo, tion No. 1191. REQUEST Application No. This applicatio, for the second year of tht 1133M). ') with Dr. Booyse P ._ 33M(A) which will NK a2lloµg Therefore, no estimate is given This will be cleared up by CTR staff. ~n No. ].191. on, the Progress -artaken within e present applica- ~ar. lesusably 4ooyse No. for the third (and final) year• DOCUMENTS SUBMITTED (attached) - 1. Application dated November 26, 1977 (page 1-page 11) 2. Appendix - (Including CVs of Drs. Wu and McKenner and manuscripts and abstracts) 3. Progress Report No. 1 for period July 1, 1977-November 15, 1977 CONA2ENT The Huma.n Subjects Certificate has been received by CTR. David Stone, Ph.D. DS/ah CTR M CON .FIDENTIAL : 1'?INNESC?TA TOBAC:CO UTTGATI0N