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9NII: COUNCIL ~''OR TOBACCO ra.SliAItCII-U.S.A., INC. July 20, 1976 iJ. K ~`d !1 I~ .1(1:~ g MEMORANDUM TO: brs. Gardner, Hockatt, Jacobson, Sommers, Stone and Wyatt FROM: CrT.U. Gardner SUBJECT: Grant Application 1091. Kenneth M. Moser, M.D., University Medical Center, University of California, San Diego, California °`Rtlationship between Polymorphonuclear Elastase Concentration and Pulmonary Functional Abnormalities in Subjects of Various Alpha-l- antitrypsin Phenoty;pe." This application is essentially a request for the salaries or partial salaries of a residency staff on a chest service. The assets are 30Pi-2Z phenotype individuals,, 150 PiMZ and about 200Pi/Affi and about 200 PiMM in a phenotype registry and an apparent active chest service that will augment the numbers in the registry and some experience with the concentration of blood PNW elastase. They have the facilities for a spectrum oi' pulmonary function tests and a Pulmonary SCOR grant that pays $27,245 yearly through 1976. Dr. Thomas C. Kravis is now with Charles Cochrane, one of the = 2 persons interested in pulmonary diseases'that he added to his group last year. Dr. Kidokoro is uncertain atiout his future. It seems that the group in general lacks much in sophistication on the chemical side and would not compare with the Turino, Cohen, etc. As I interpret the proposal it is basically the support of a Pi registry with pulmonary function testing, history records including smoking, pollution exposure and therapeutic responses. The parts that differ from the other work being supported are the comparison of the blood and pulmonary macrophages and PNfiTs, the longitudinal follow-up and possibly the fate of 1251 and 131L labelled alpha-l-anti T. The budget is primarily for personnel. Any part of the total would be useful. It is my impression that this tvill not contribute as much as the other projects that CTR is supporting. W.U.G. WUG:mb