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7'iri: C'orxc•u. Tr>>r'I'crrsA<•c•o 1NC•. GRANT APPLICATION NO. 1297(M)R1 January 15, 1981 CANCER ~./ .! HIc01334216 !/ TO: The committee comprising Drs. Gardner, Huebner and Jacobson SUBJECT: Henry T. Lynch, M.D., Creighton University, Omaha, Nebraska First Renewal Application No. 1297(M)RI "Genetic and Biomarker Studies of Smoking-Associated Cancers" HISTORY This investigator has been supported since July 1974 in studies entitled "Smoking History in Families with Low and High Risk Cancer In- cidences" ahd "Statistical-Genetic Evaluation of Risk Factors in Lung Cancer". Application No. 1297, same title as the modified application, was deferred by the SAB in October 1979 for clarification of aims. Application No. 1297(M) (modified in accordance with the SAB suggestions) was approved by the SAB in April 1980 at a level of $93,426, as reque sted. RE UEST Application No. 1297(M)R1 requests of the project. LOCUMENTS SUBMITTED (attached) 1. Application dated 12/19/80 (16 2. Abstract 3. Progress Report No. 1 10/31/80--plus Addendum. COMMENT $99,966 for the second year pages). covering the period 5/1/80 through This application will be in the April 1981 Sia.B agenda to allow for a full discussion. ~ DAVID STONE DS/lp Encls.