Tobacco Documents Online

r I ~ Oct FS !J 7'»>`. ('<n•.Nc•iL Fcut Tc»s,icro I:i>5rAaaclt-I".S.A.. INr. OdA , .,tr August 1, 1980 GRANT APPLICATION NO. 1143AR1 1j K 0 10 3 6 11, PULMONARY 1 /1, TO: The committee comprising Drs. Gardner, Meier and Somers SUBJECT: Aaron Janoff, ]Ph.D., State University of New York at Stony Brook, Stony Brook, NY 11794 First Renewal Application No. 1143AR1 "Further Studies of Suppression of Protease-Inhibition by Cigarette Smoke" HISTORY Application No. 1143 entitled "Part 1...Suppression of Proteinase Inhi- bition by Components of Cigarette Smoke: Part II...Induction of Alpha-l-Anti- trypsin Synthesis in Liver Cells", was approved by the SAB in April 1977 for a two year period, as requested. Continuation Grant (No. 1143A), (a two year request) entitled as above, was approved by the SAB in October 1979. Budget estimate for the second year was $21,195. REQUEST First renewal application No. 1143AR1 requests $21,193 for the final year. DOCUMENTS SUBNITTED (attached): 1. Application dated June 5, 1980 (8 pages) 2. CV of Dr. Janoff (11 pages) 3. Progress Report No. 5 for period December 4, 1980 to June 10, 1980 (7 pages with Face Sheet) 4. Reprints (4 in number - all acknowledge CTR) 5. Preprint (1 in number - acknowledges CTR) 6. Abstracts (5 in number - all acknowledge CTR) COMMENTS 1. In April 1979 the SAB approved a one year request (Grant No. 1259) entitled "Immunologic Assay of Lung Elastin Degradation".. 2. As noted (See ?tem 6 of application form) the project continues in a flexible, even ameboid manner to cover related aspects and targets of bpportunity within the main thrust of the working hypothesis. 3. As progress appears to be satisfactory, this request will be handled administra- tively and withheld from the bulky SAB agenda for the October 1980 meeting, unless you obj ect. DAVID STONE DS/agm