Tobacco Documents Online

iar;.. . TIIr•, Coc:.cll. FUR'1'UI3ACCU KESIiARCII-U.S.A.. T.N('. '',J?~~J . .` ~ August 17, 1981 QtArTP APPLICAPICN NO. 114 3B PUIbCKkRY T0: The mk~nittee omprising Drs. Hotoden, Gardner and Sarmers &US7rX:T: Aaron Janoff, Ph.D., State University of New York at Stony Brook, Stony Brook-, NY 11794 COntinuation Application No. 1143B "Limg Protease-Antipxvtease Balance in Ciganette S7rnkers" HIb'1C)RY Application No. 1143 entitled "Part 1...Suppression of Proteinase Inhi- bition by Cmponents of Cigarette Smoke:, Part II... Induction of Alpha-l-Anti- t>Yypsin Synthesis in Liver Cells", was approved by the SAB in April 1977 for a two year period, 1s requested. CYmtinuation Grant (No. 1143A), (a two year request) entitled "FUrrther Studies of Suppression of Pratease-Intiibition by Cigarette S<roke" was approved by the SAB in October 1979. REQqE.'S TT Comtinuation Appliaation No. 1143B requests $103,107 for the first year , of a three year study. Budget estimates for the second and thi.rd years are $109,710 and $116,293, respectively. (See note on Page 5 of GTR Applica- tion fone "Other Sources of F'inanCial Support" ). DoLZflNIMIS SIJBNIR'tED (attached) : 1. t~pplicati~ dated June 1, 1981 (9 pages) 2. 8`iographical Sketches for Drs. Janoff, Carp and Raju (6 pages) 3. Frogress Report No. 7 covering period Dec. 6, 1980-Tune 1, 1981 (10 pages) plus 5upplement (3 pages) 4. Reprints (11 in number - all aclmawledge GTR) 5. Manuscripts (1 in rnmber - ac)mowledges CPR) . CMM 1. Ftisoan Subjects Certificate has been received by G'PR. 2. Oopy of Patient Informed Oonsent form for Lavage procedure. 3. Patient questionnaire for gmking status just prior to lavage-procedure. David St,one AS/am