Tobacco Documents Online

.S ea g~L~p r ro I P,-a~ 6, C rs TII?: C()l ICCIL FOR TG?BACCU RESEARCII-U.S.A., INC. Ft/~ HKO0996~~03 ~~~• January 24, 1980 GRANT APPLICATION N0. 1201R2 , N CP.RDIOVASCULAR TO: The cormnittee comprising Drs. B ng, Jacobson and Sommers SUBJECT: Lcuis A. Soloff, M.D., Temple University, Philadelphia, PP Second renewal application No. 1201R2 "Immunoassey of Lecithin Choleatterol Acyltransfera~'se after Eating and Smoking in Health and Ptherosclerosis" HISTORY v ~4~ U G First great in 1966 (#5].9), renewed annually thereef'ter, was for studying possible effects of smoking on serum Yree fatty acids, cardiac per- fors:ance, fat metabolism and other phenomens. Numerous papers were published. Interest became centered wholly on LCpT from 1971 onwardo Grant No. 51902, July 1, 1976 to June 30, 1977 (and extended), was considered finally terminal. In April 1978, on the basis of new LCpT assay and prbsaising new findings, the SAB approved a new application (Grant No. 1201) entitled "The role of lecithin cholesterol ecyitransferase (LCAT) in cholest~erol transport to and from peripheral tissues and its modification by smbkingn, for a three year project. First and second years funded as requested at $59,464 and $64,429, respectively. Third year budget estimate was for 6 811. IMQ= of Applicetion No. ]201R2 requests $68,01 for the finaJ. yearf the project. DOCMMNTB SLBMiTTED (attached) 1. Application dated 12/29/79 (4 pages) 2. Progress Report No. 3 for period 1/1/79 including Face-sheet). COMMENT - 12/31/79 (8 pages As progress s to be satisfactory, this application will be handled administratively withheld fr~ the bulky SAB agenda for the April 1980 meeting, uN es u object. ~I &,.*A .v*•t,1 Ii6R )~11'l ~-e-t j A b DIVID sTON$ ~ DS/lp Encls.