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Tim Cou.cAr.Fui:Tuimcco Rt:Sr:,lii/'ll-L.S.A., l.c. &KP[C O-r il,~'rtl l5'PPGA~4'' Cxtl ItJ _-^------ .. "I'll ~----- Grant application No. 1064 PUIM0Np3Y To: Subject: History Re est HH®0829014 The coacnittee cocprising Drs. Gardner, Jacobson and N.eier Gerald M. Turino, M.D., College of Ptysicians ahd Surgeons, Columbia Universit:jr, :,. Y. New applic%tion No. 1064 "Chemical Basis of Tissue Destruction in Obstructive Lung Disease" A previous application (No. 1050) with the same title was denied by the SAB in October 1975. The present application (No. 1'J84) with a drastically reduced budget request, is a revision of the previous application, elininatir.g studies relating to nitrogen dioxide and ozone, and focusing oa the elastolytic activities of alveolar a.a.crrronages er.d poly=orphosuclea..r leucocytes in both hunar.s and animals. Application No. 10E4 requests $32,359 for the first year of a three year project. Estiaates for the second ar_d third years are $34,947 an3 $37,743, respectively. D'ocvaent submitted (attached) Co=nents Application dated Oecember 31, 1975 (19 pages, includi:g C.V.s of L'rs. 21xrino, Fierer, D:andl, and Parshley ) . 1. hr. N.ana.1 has previous'_y received six years' support (19c6-1972; from C:-R in this general area for studies entitled- "The Role of :ieredita_•-y Elastase Inhibitor :ef icie::cy ir. tre Dtio_cq- of Pul--ona_ry ~h~rse a a.^.d ~.:astolytic Breakco.n in the y.ioioqr of ?u'..^.or.ary I~ hysema".