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H100523002 Memorial Huspafal of Ctiesler Coun1i, WEST CHESTER.PENNSYLVANIA FREO W. SCHM10 ADIAIN16iR-70R February 18, 1963 Robert C. Elockett, Ph. D. Associate Scientific Director Tobacco Industry Research Committee 150 East 42nd Street New York 1.7, New York I Comments on the paper entitled "Experimental Study on the Effect of Cigarette Smoke Condensate on Bronchial 14Iucosa", by E. E. Rockey, et al. , JAiyIA, DecPmber 15, 1962 Dear Doctor Hockett: After reading the paper by E. E. Rockey, P+ a1., JA11IA, December 15, 1962, I feel the most pressing need is to obtain permission from the au- thors to examine their materials, (if necessary or convenient in their own laboratories)in order to more fully evaluate particularly the changes the authors list as "precancerous" and "carcinoma in situ". The same evalua- tion of squamous metaplasia as theydifferentiate it from squamous metaplasia with atypical features could be made during such an examination. Until such an evaluation is made by unprejudiced, competent observers and until direct examination of slides, such as those shown in Figure 7 and Figure 8, both labelled "invasive carcinoma", and which any trained observer would agree are technically useless, as photomicrographic reproductions, the matter of the purely scientific importance of this paper must remain unsettled. Slides requiring further study include Figure 6, a photomicrograph of carcinoma in situ, which although clear, certainly would not be accepted as such by any majority of qualified pathologists. The photomicrograph shown in Figure 3 and labelled "precancerous changes", cannot possibly be accepted as such without further detailed study and higher magnification. The higher mag- nification shown in Figure 4 would also leave much doubt in the mind of a patho- logist regarding the true nature of the so-called precancerous changes. Very truly yours, __7 RWW.jml ~ ! 40 tvr Wt Russell W. Weller, Al. D.