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i .Q- i„ 1 1l_"~~J1' , ~ 'In 12 of 4iw 18 asuta2,ir Aisturbing avants *st oaaurs.a aharUy tia• !ax 0e aos.t os illassS, thext ww Aoms .bsmsat (tbaa,tencS or aoto1) cd .apsa+stios !'rm ae lose of sasaaas ohos.. Ois Walv.d O. +eir. In 9, the mothqr (or amt) in 2, o+act the father !.n i.... (Ooly 3 patients of the 25 seemaQ to bam escap9dd eaq.leli4ly rm 1m6gs3 !lotossr amd tbe'y rare "At this point In onr lovestigst.t®, it beosae a,yparent tbag it aas •soeaaary t* Costrol aner 'eemtrcl' groo. ve th.refare ftdi.d 10 yatients ot the saw age groua vith proved acvrte appeadioitie aeG 10 tdtt Vanumorla. 4l+o obsuntieas ecasa.rning erwirowa*nte.]l eisvrosstsnoes pd aaotxon4l lsturaa In these Qoups ersre In general qail. aaewaeable to thm.e describ.d In tb.e VatieaCa Yitb b.'patiti,s.... "'rbe oDssarratLOm a so iwqy saute and /twsly IApefttdlg sarpeiianeso before the aeset of lllnssc is of intereat.... Pmriaas eepor as aa w].l se the Wasst .tuqy inidicate thet aQUte],y qpsettieg matiaual .oq.riaaoss are e®oa beforo Lho oeset of e.ariet; of illaessss. Gbeerntions ss%wh as these are subject to at lsest twr genwa1 ioomp.tat.iaas: afadaw1 tts. Uvas aay be an inporteaat dutcriV-ma..zt of sv.dsptibility to avuiety of d,isas,ivn; aad sw.t. .rpisode:; mey merely be part of the liriog prc+Qass and sePosent oaamrrsacaF li+s,t bear enl.y a obanae, teeJpor&7 Watiam to tbe aeset ct aouaaie ia]a+ms.... It is or interest tiat, in tlte asse atwtlly, bstiaat.a Vith aeuroBis AS : no6 lrzrc a bigber prs.alense ad heatitis, ap- p.ndieitig, or ynsisanic thna V:e erxrt:no1 Oww aLthough Us teW ossw. s'anae & scwnt.ia disaase rrae qwarantly higher thau itt the control glroe (oaust, 1952). Ia saosnt ysass the saetoaomous asrnaue .yat.m apd t!r a4- reus' g7sW s 2:are been eamsiQere3 po¢e3b1e soutes by Aid: ysyehio Sbenu- sroaa spy influnnes suseeptihlltE,+r aed ste+siotsqae (Valya, 1%6; Lwasm, IM)• IT. is mr aPluion that a1t.`•cAI& the gresent stsbe of knoArledgR A11qa lo the ponsibilitr Vat lsYeboloee !!ebw'bsmas a#Y+.at avsiatewe to difiaNi W Praaf of aviah a re1atim is nc+t a.tsbliWod.... ''he aatf.ra problm of the 'emtrolLse' study In psyehasaaFStie i:oresU• sation is bott 1litfioult ea• ireorkaft. It is aaCually a 8ve : we in thM a test pougut iaw r1Y b• oalwaasd as3th a'amal.' groyp as re11. ae tiith other wsmbexls af the awoe VocUent Popu7atloa. Altboqft Ua taftmKva ia- ri.a: iim tise stWLy or both varieties ad odotrol paaSs is iwport", it io apapareiat tbat the atudj ad 'aarw1 aalbasats' je as--- Wiat obaboa]ss ( Dwit%c, ],¢. ;; aroadcw at al. , 1954)• 'Z9ww are tbs obvious Qifticulties in.olwQ ia tbe saZ.ot iao et a 'oaa+al' aaartral Wuo, a.d, as iadieat.d Onw, .wn !f sash a gaV L Mleotad, tb+a iatemtion dbladanQ !om a %aallt:y' *o1satRSr Med aot 1! .osq IN aDle to tfy aata d.rir.d !'m Uue ws 9woas helag i.]tnew. pr tisttcs rram the ioseeziLl pWA•tica b.." ti.n as.a a. 'eostral' a.ea, twS lhie s~Woa has the saetou. lt'tde.tica ar islWft V, ap. tat do roS eml:ibut,e to 4bs parQiaular yaUsat popS.aaa wAor ap.aial. .cralO-Mias.

-3- H15004001 ; °on the ctlar hM tle® otwr ar eth.ar a roWs a! "ttsnC. ~ t~ar t}x "M smu%: "mt vwdattm prort,d.o . .om ratw+mmt .matral ONELs for ob.er.ettamv md= amdtUoos of i7.L.., Csd boald.talsXSUas (DWJW. 1945).... ~thx mMNLLhy ot wl.aties of •.alla .0ob01 Wow is os.m... L'aa quo-stion of ldwt4e.r the uao ad' eoutr&W as eap]asd in atbsS bZC1Zo,;LC Wden= 16 at 4Lu /ypUenW6 to 3p/yabl&tftd 11tgUSS bN bNRt * r11 t..~:C' st.Le;- of aOaloZOgiC and t/DtrZOol "VwtA Or PsYftbOsmmUc d:•.st-m-se ,t ie amidww emmt3a1 to haw oarhtral ahmastiam = aa e3ts---ix oaMlMsW)le Pats.at pegPx].tion rcW tb..jgattse~ ot fn ftad.tep to be iatsrprsW sa aq ast paW. •.