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v THr C.acaCILFaeToBacco RtaLaRCH-L".5.A., Nc-. = GRANT APPLICATION NO. 1322M ~ . ) -1 . 4, r 1+1I t )c 1 July 3, 1980 at~$G=re 3 ''0 PULMONARY / TO: The comruittee comprising Drs. Gardner, Meier and Somers SUBJECT: John E. Repine, M.D., University of Colorado Health Sciences Center, Denver, Colorado 80262 New Application No. 1322M "Basic Mechanisms of Lung Injury from Inhaled Oxi.dants: Elucidation of the Role of Hydroxyl Radical (OH) Using Dimethyl-Sulfoxide (DMSO)." HISTORY Applicar.ion No. 1322M entitled as above is a revision of an application (No. 1322 entitled "Protection from Cigarette Smoke Induced Lung Injury Using Di- methyl-Sulfoxide (DMSO) - A Scavenger of Hydroxyl Radical (OH)" which was denied by the SAB in April 1980. (See le.ter to CTR dated May 15, 1980). A previous application (No. 1266) entitled "The Role of Phagocytes in the Development of Centrilobular Emphysema" was denied by the SAB in April 1979. REQUEST Applicar.ion No. 1322M requests $89,461 for the first year of a three year project.Budget escimates for the second and third years are $91,393 and $99,221, respectively. ;The original application (No. 1322) requested $68,571 for the first year with estimates of $75,226 and $82,674 for second and third years respectively). DOCUMENTS SUBMITTED (attached): 1. Applicst+.on dated May 9, 1980 (14 pages) 2. Letter to Dr. 9ockett dated May 15, 1980. 3. CVs of Drs. Repine, Talmage, Harada and Tate. Also Ms. Berger and Groeneboer. 4. Reprints (3 in nmber) 5. Abstracts (5 in number) 6. Letters (4 in number) to Dr. Hockett) COMMENT Copy of the Human Subjects Certificate has been received. David Stone