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Copy Fxh:b:+'s UNITED STATES DISTRICT COURT EASTERN DISTRICT OF TEXAS TEXARKANA DIVISION THE STATE OF TEXAS, . Plaintiff, . vs. . Civil Action No. 5-96CV91 THE AMERICAN TOBACCO, et al., %I. Defendants. 10 11 12 13 14 15 16 17 18 19 20 21 Baltimore, Maryland September 12, 1997 Videotaped deposition of RICHARD E. KOURI, Ph.D., A Witness, called for oral examination by counsel for the State of Texas, taken at the Harbor Court Hotel, 550 Light Street, Caucus Room, before Shari L. Nelson, Notary Public, beginning at 9:50 o'clock a.m. Reported By: Shari L. Nelson, RMR-CRR Riggleman, Turk & Nelson (410) 539-6398 RIGGLEMAN, TURK & NELSON CTR HN 04-3GS2

Richard E:: Kourl , 4230 Buckskln Lake Drivs - EIIIcott City, MD 21042 EtlUcatlon 1971-72 Post Doctoral Fellow Roche Institute of Molecular B1obQy, Nurisy, NJ 1968-71 Ph.D. Radiation Blology Unlvenllty of Tennessee (Oak Ridge National ~ Laboratory) , KnoxvNls, TN 1967-68 M.S. Radiation Virology Universtry of Tennessee, Knoxville, TN 1983-66 B.S. Microbiology Ohio State University, Columbus, OH Work Expsrlencs/Accompllshments 1997 May ` Pr.sld.nt, Chl.f Ex.mdvs Officer, VIMRx O.nomlcs, Inc., Naw York, NY and S.nlor Vice Prssldsnt, VIMRx Pharmac.uticals, Inc., Wi1minBton, DE • Manage the /ofnt venture between VIMRx Pharmaoeutkals and the Columbia Genome Center, Columbia University School of Medicine •"Organize, priorftlze and o.ommerctalize penomlcs activities (esp. In areas of cancer and neurologic disorders) using gene discovery and mutation analysis: and, furwtlonal analyses using ribozymes, transQenicJknookouta and bbinformatk:s. 1997 Jan-May Business Development Analyst, Office of Technology Licensing, The Johns Hopkins University School of Medicine, Battlmon, MD • Co-founded VIVEX Therapies, Inc. /oo-authored Business Plan • Organized and licensed technologies from Dept. of Pathology (Hopkins), NUID, NIH and Univ.of Virginia (use, of soluble oompiement ,.inhibttora and solubte transplantation antigen oo-nstnxts for the dinlcal ; manaqement of aNogeneic and xenoDeneio organ transplantation) • Orchestrated and Initiated Company contacts fo'r:flrst round funding 1994-9a Founder, Director, Chief Operating Offlcsr; Chlef Technical Officer and Senior Vice Praid.nt, Gsni Logic Inc., Columbla, MD • Incubated,validated and licensed Yab Unlvenslty-based technology ~. • Co-authored Business Plan / hired CEO / orchestrated road show and oompleted $10 M round of venture financing from consortium led by Oxford Bioecbnoes and Hambro Amefica • Supervised the evolution of the core gene display and transcription factor capture technologies from manual to automated high- throughput formats • Inftiated agreements wfth Yale Univen;ity, Univ. of MD Medical Center, Johns Hopkins Medical Center, U. Mass. Medical Center, Univ. of Colorado Medical Center, and 8aybr Cotleye of Medicine for accessing key biological materials and expert consultants • Evaluated and managed aNlanoes with National Center for Genome kourirsesmart.nst 410-6.11-S26 41a331-4e2e(FA)q C T R . HN• --0 4 -3 6 S:4'

Resources (Sante Fe,NM), National Center for Blologbal Information (Biethesda,MD) and Division of Computer Research and Technology (Beftsda,MD) for bbinfomnaths and statistical support 1995-96 Adjunct Assodate Professor, Department CNiutar and Molecular Biology, University of Connectlcut, Storrs, CT 1 g95-o8 Adjunct Resarch Professor, Department of Genetics, Yale University School of Medicine, New Haven, CT 1986-a7 Chairman, sIOS Laboratories Inc., Kew Haven, CT 1986-94 Founder, Director, CEO and Presld.nt, 8109 Laboratories • Generated over $7 M In private plaoement capital led by ICF Inc. Vlenna,VA, Conn. Innovatlons Inc. and the Ctty of New Haven. • Authored and awarded over $4 M In government grants and contracts • Managed research product division that averaged as0.6 M/yr In revenues over the psat ftve years • Uoensed products to Amersham Corp., Visible Genetk;s, SootLab and Toyobo • Managed three dlvislons totaling 1845 peepb 1986-89 Founder, Director, Director of Ressarch(psrt time), GenMap Inc., New Haven, CT • Co-autfiored Business Plan and generated $3 M In venture capital led by Oxford Biosdenoe, MVP and Ventures West. • Managed staff of 10 Induding 3 Ph.D.s 1983-86 Dlrector of Ressarch, International 81otschnologies Inc., New Haven, CT • Set-up Research and Development Division / managed 5 person staff • Authored and awarded $1.2 M In government research grants • Co-authorad prospectus for successful IPO 1971-83 Director of Research, Mlcroblofogicai Assoclates, Bethesda, MD • Managed staff of 60 Indudlrg 20 doctorate level Individuals • Authored and awarded grants and contracts valued at >$12 M Technical ExpertlseJAccompllshments • Documented expertise In molecular bblogyhnolecutar flenetlcs, tissue cutture, mutagenesis, carclnogenesls, Positional Gsne Analysis and Candidate Gene Analysis • Specific Interest in Funcrional Genomks as embodied In methods for display of gene ~ expression patterns and control of these patterns by transortption factors • Authored over 110 manuscripts, 70 abstracts,3 books and 5 patents • Presented seminars at over 100 national and International forums • Recent Past Member :'Immunology and Molecular Slofogy" SBIR Study Section, 1984-94 (Chatmian); `By-Laws C`~onxnlttee', Am. Assoc. Cancer Res.,1990-92; "Suboommtttee for Genetic Predisposition to Environmental Carclnogenesis', NSF, 1990-92; 'Search Committee for Blotech Center Director", U.Conn., 1994; Committee to Establish Policy for AcaderNc-Industry Relatfons", U. Conn., 1996; Steering Commtttee for the 8lotschnoloqy Center', U.Conn.,1995-96 • Present Member :'Flnanoe Commfttee', Am. Assoc. Cancer Res., 1994- ko ur1 rs A s ms rt. nst 410-01-4s2Q 41 a631-0Q2a( FIJQ CTR NN 043GS4

RICHARD E. KOURI 1972 Post Dociarat Fetbw Roche kwtltuAe of Molecular Biology, Nutley,NJ 1971 Ph.D. Untveraity of Tennessee, KnoxvNle, TN (Radiation Biology) 1988 M.B. University of Tennessee, Knoxvtrie,TN (Radiation Virobgy) 1966 B.S. Ohio State Univefslty, Columbus, OH (Microbiology) ~ 1997 May President, Chief Executive Officer, V1MRx Genomics, Inc., New York, NY and Senior Vice President, VIMRx Ptttvmaoet~tk~ls, Inc., Wfmingfon, DE. ManaaesCen~r venture between VIMRx Phamtie~oei~lcals and the Cokxnbia Genome , Columbia Unlverslty School of Medicine. Organizes, prioritlzes ~oortx bes awanics ~( in areas of carroer and ~ ~ r~ m gene ~ analysis; and, functional ueing rbozyrnes,iransQenicJlcradca~ts and biokHormatks. Business 1997 The M~~ Hopkins Unhreretty~of Msd~` Office Battl~moTechnology re, ~~~~ Co-fownded and a+5t~ored Bu~akness Plan for ~Van~e ~~. Organized and licensed fechnobflies from Dept of Pa~ ~olo~r (H~opktVMS nsrt ID~giH and Univ.of Vkflhia. Techrwlosjy was based ~olubleon soluble tra R%A= luxukm I arfuuert oonstuets br the otWcel manaQernent of abpene+c and w~rx~oer~eic~ fi~ tatlon. Orchestral ed and ktitJated Company 1986 -1997 ~x f~ratFounder, Chairman, BIOS t.abofaforfes, Inc., New Haven, CT, Consulted on overall strategy for company. Evaluated funding allbema5ves espedalfy h area of dei~~~b'p- lnp tecFmolopbs as separate oompanbs. 1994 - Dec.1998 Founder Chief Operating O(fber, Chief Technical Officer and Senbr Vba President 6" Logic, Inc., Columbta, MD. ManaQed day-b-day actlvttles of psr~y tt~at tnckuded Infiouse personnel, oubfde suboontracbrs, and reeearr~p e~anoas. Atthored end menled Technical Operatln~ Plan of R ~S1 OM~ ~ for novel ~~ ~ ~ for,g ~~ 1995 -1996 AdjUW Research Professor, D9parbrtent of Genetics, Yale , Unfverstty School of Medicine, New Haven rT., 1995 -1996 unct Research Pro4eseor, Deparbnent of Cell and.MoW" Biology, U of Connectfaut, 8iorro, CT. 1987 -1995 AdJunct Research Professor, Dep&vment~emb bgy and PuWic Health, Yale Untverstty School of Mediclne, New Haven, CT. 1988 -1995 Founder, Prestdent andDirecbr of Research, BIOS Laboratiorfes, Inc., New Haven, CT. Coordinatied all activities for yearty planningbjdgetary cycles. Authored and montbres Operation Plans kx three dtvlsions of company -- Productbn, Sales/Markefing, and uct Development SupeMsed ar ooNaboratora and r~epera In R & o laborabry. Responslbie 1or jolM dewebpment pro)ects~~ wfih oorporate dients, and pranls and oontracxs tor government-sponsored b~ research. ExQanded revenues by 90~61n each of the last twoy~ears people In oorr~pany. Ralsed mbd of 67 M{n placement funds for company. . kourl r.0 s mart.n.t 410-d.11-OW 410-611-4Q24lFAX1 CTR I-IN 043655

, InC. 8oobn, MA. 1987 -~s~ for bec~nlcd d ~ 0~ oompany for fkst two years and member of AdvisorydvWmp~{~r1dW~ COordhal9d propri9f3ry strategic pr~OpObr at10n for 9OV~@rnrTlent and nongovemment sponsors. Fiehped gerrerate .6 In venture tunds. 1954 -1996 Vioe Prestdartit, Dkeobr of Reeearch, Irriernatfoned 8bbadMbples, Inc., New Haven, CT. Aeeponslble for penersting new techniques and equiprnent In order to educate and support 1he rrwlea,Aar bbbgy comrnunfty Particular Intsreat is in the ~ of spedrtc genetic sequences and ~eir role in risk to p human dbord ers. Reeponeibie lor flow of Wormdon between it~e R & D div~ and oommeraal qpplicatlons. Co-&uftwed prospectus for sucoessful IPO. Ralsed addltlonal $1.2 M In grants and oonftft personaMy b fund toese actlvftbs. 1977 -1984 Vioe Presldertt, Direc.'br of Reeearch, ItAfCrobb Associates, Bethesda, MD. Respor>We for daY-b-daY management of 'rofeasbnals dist*utad Irft four teotm{ca! Divisions: To and Ntoiecular Bbbgy, Genedc To o~o~y,p1~ nostlc 8ervloes, and Services. R~b1e for oost~c~t safes wlt~iln these Wvblons and beMreen research and oommeraal Pt~r ~. R1o ~nt a~nd n~on ~maertt~aie~ts.YR~abed Wkeft h grante and oontr~ ac~a pereon~~)ty to fund theee actlvitles. ; 1979 -1984 Head, Division of Toxbology and itAofeWlar Bb , MicrnWobgic~l Associates. Responslble for day-b-day manaQernent of sevenb~rectsons and a total of twsNe proftesbrials. Coordnatbn and expansion of reseanch directions in ttre areas of short-term b o~obgy wd~o~ are prtme 0bjectives. The newer tectx~iques ses of moiecular bblQgy form t(1e besfa tor meetfrq these o*c,tlv+es. 1971 -1984 Head, Sectbn of Bbchemicd Ona~Ma+ob~l~~gfcal kxkjdbV n. Project arec.'br r+eapor~sble iorsApr~ sbnthis vfw and In vItro effec~s of eVosure b fe Wette amoke end cigarette smoke Oondensat9 maf9rial6 and the penelio control 01 susoeptbilky b chernicalfy- hckioed canoers in aneb. 1970 -1971 Post-cfodorat F.eNow, DRoche ir>s~h~ of BbbQy,I~lutley,~ Neovfv'breey. m~etabo~sm In mice geneft and c~ybQenet~meftadsafa~ r~r~~p qmelhe mouse o?xo using fkjoron'~e~ric, adiome~ric, penetic apprnactres. ~ Fund ratsing from venture sources, priva0e pteoements, research alftanoes, and grants and contracts fNrtt bOth flOVerrKfl9nt and OOfpOfatlon8. Propriesary protection strategies, haudinD patenb, oopyrighta and trade secxets, Functional Genomics in areas of display of gerte exPresslon patterns and control of these patterns by trartsaiptbn hrabrs Mettads relatlve to MoleaJar b~i~a1 yeft ar d~na! ~ Anal~jrsi,4, m~, cararagenesis. candidate Gene Molecutar genetbs of predispositbn b Canoeddegenerattve diseaees. CQen9tk diepnoeis In vivo and In vttro bAoobgbal bbaasays kourlr.*emert.nat 41Od31-" 410-a31-4S2d(FAX) i ) CTR MN 04,3GSG

: Lectures have been presented at over seventy natl~onal meetinQs and twenty IntemaHonal fa'ums. Pos Colfitveun y~Caflfomlavan~Fr~, E1~ectriDcrP r FFe9insl,, ~ 1~eseCocx~cil, ~~ Internatfonal Agency for Research on Cancer, areat Plains Coal Gasification Prn}eat, and bts commercial organizations. Commlttee member for Environment MutepenSociety, Tissue Culture Assodatbn, American Association for Cancer Research and AmeriCan Coll~w of b*oioQy. Revfewer for nine ; sclentlfb joumals. Stbe oommlttee member and reviewer for the Natiortial Canoer Ir>s'kils, Nafjonal tnstttule of General Medical Sclerroes, Small Busfness Innovation Research ProQram, Environmental Re Probectbn~~ger~cy, Electrfc Power Research kts~ule, The Cotxtod for Tobacco ®earch, and the Veteran's dmin _lstration. Member of p~ 'Health Effects of Poone ard Selected Mafop' Divtsion of Medical Sdences, NRC, NAS,1983. N of panel 'Applof 8bcherr" Marfcers In Risk Aasessment,' NIEHS, NIH,1986. Revlew board member of "C prrvsntbn Decision Point Commtttee; DCPC, NCI, NIH,1988 !01969. Co-Chalrpereon O~~aupi~Zinp ComrrtikDae of the American- Soviet Synlposium'aertietfc Approaches for DetemNnlnq Pre~lti.n to Mental Dtsease~s',1990. Chairperson of Immunology and Moiecular Biology 8tudy Sectlon, Small Business Innovation Research Program, NIH,1984 b 104. Member of'Byt.awa Cortxnlttee', Amerk~,en Assode5on of Cancer Research,1991-1993. Meber of't~egtslatlve Conxrttttee', M;eric~n Aeeodatbn of Cancer Research, 1992 - Present. Member of 'Flnanoe Comrr~tttee ", Arrtier{cen Assoolallon of Cancer Res,1 993 - Preserri. Member of'Sear~ch Cortmttlee for Dinodor of Bbtecfxab~y Center', oi~Connecticut, 1993 - 1994. Co-chakperson, ~Y Suboomn~tttae, Conn: T~u ~~,1995 - 1996. Member of UnMerslty-tndustry Inb9rac~on Co ~ofa 1 9.1988. Member of Board of SclenGfiC Cotmsebrs, ~ AmwScan Association for the Advanoement of Science American Association for Cancer Research American of To M~>ask~x Soaety o~r Microbiology - Human Qenorr~s Society for In Vftro Mat= Kouri, R.E., t..ubeL RA, and Brown, D.Q. Cellular Response to Benzo(a)pyrene Measured by a Mbro-fluorometrlc Technique. J. Cel1. Bio y, O:72a,1969. Kouri, R.E., lubet, R.A., and Brown, D.Q.Effects of X-rays on Uptake of a Cf*mfcal Carcinogen, Benzo(a)pyrene, In Individual Ce#s In Culture. Rad. Res. yWOb-5) 262-283, 1970. Brown, D.Q., Lubet, R.A., and Kourl, R.E. The Relationshlp of Aryl Hydrocarbon Hydroxylase (AHH) to Benzo(a)pyrene Induced Cylotoxlcity In Cell Cultures of Hamater Fetuses. Proc. Am. Assoc. Cancer Res. t~2(192) :50, 1971. Kouri, R.E., Lubet, R.A., and Brown, D.Q. X-Irradlatlon Enhanced Beno(a)pyrene Carclnogenesis. j,Q. Vft. Rad. Res., Q:(Cb-9), 1971. 8enedlct, W.F., and Kouxi, R.E. Are-C-Produced Trsrlsfomiatlon in Harnsfer Fe#al Celfa. Proc. Arner. Assoc. Cancer Res., J4:94,1972. Benedfct, W.F., Karon, M. and Kouri, R.E. Malignant Transforrnatbn Produced by Cybsine Arabinostde. Pediatric Rea, p.72, 1973. Meth , ychdar~re~roc. Xl. Irttsmational oCaf~oer C~orqr~bp.C77 1974 ~~ ~~ Koud, R.E., Whttrnfre, C.E., Benedict, W.F. In Vtvo and In Vitro Effeas of Clparetts Smoke Condensate Fractions. Proc. Am. llesoc. Cancer Rea, jj:173, 1976. kouNr.6smart.net 410-351-S26 410-651-962a(FAX) CTR NN 043~'~57`

, Alfred, L, Torrafba, (3., and Kourl, R.E. Ary1 Hydrocarbon Hydro~rylase inductfon in Cultured Human Lymphocytes. Proc. Am. Asaoc. Cancer Res., ]Z:151, 1976. . Schechtrnan, LM., Iekar, R., Kurtz, S. Dtvefy, 0., and Kouri, R.E. Studies on Molecular Meohanlsms of 8enao a~)pyrene ( -Induoed Cybb*Ity and Transtormatlon Usinp SpeciAc Sources of Mixed Fur~ction a3daee AMAw Proc. AmAssoc. Cancer Res.,1Z:174,1978. Koud, R.E., McK", C., Sosrawsid, R., and Sctrechtman, L.M. Fadors Inlluendnq Aryl Hydrocarbon Hydroylsse (AHH) Aotivtty In Human Lyrnpho~. Proc. Am. Aseoc. Cancer Res. l@:150,1977. Koud, R.E., Jogsekar, R., and Schechtman, LM. Quantitative In Vttro Metabolism of Benzo(a)pyrene (BP) to Inlennedtatss Cybio& and MuWwic to Mammalian Cefls. Proc. 8th Mnual Meeting Envlrorttnental MuMpen Sodety, 19T)'. ,. Koud, R.E., Beard, S.F:, and 8ohectrtman, LM. Sirrultaneous Quantltatbn of Chemicepy-induoed Transiormation Frequency and Mutatbn F ~y of BALB/3T3 CeNS in Cut4~re. ProC. ~th Ar~nual Meeting of the Environmental Mutagen Society~.77,1977. Radtke, H.E., Rude, T., and Kourl, R.E. Evidence of Heterogeneity of Hepafic and Puknonary Epoxide Hydratase (EH) Actlvtty h Inbred Strains of Mice. Proc. Am. Aseoc. Cancer Res., l$:142, 1978. Bi9ups, LM., Hennr. C.J.,1Mhitrnire, C.E., and Kourl, R.E. PathoQenesla'bf Chemicaly-Induoed Lung lssbns in Mbe. P~r+oc. Am. Asaoc. Canoer Rea.,1fl:142,1978. ; ;, . T-, Lpf~octyeee.~Proc., Am~Aaeoc. ,Canoer R.,~18:74,197F8.~rocarbon Hydroxytase (AHH) in Human I~fuoed Ce~inoerd., PrEoc. A~m. S~oc., JM anbblo2p 7~'2N197 .E 8 and Susoeptibilky b Cherrdcally- Henry C.J., Bilkips, LH., Avery, M.D., Dansle, D.R.,l.opez, A., Broth, L.A., Rude, T.R., and Kouri, R.E. Lung 6anoer Model Systerns In lnbred Strains of Mice. Proc. Am. Assoc. Cancer Res. 29242,1979. Rasmussen, R.E.,8oyd, C.H., Henry, C.J., and Kourl, R.E. DNA Repair is Reduced In Lungs of Mioe Exlwsed b Cigareft Smoke. Proc. Am. Aseoc. Cancer Rea, 29242,1979. Hen , C.J.,Lopez, A., VIR~itrMre, C.E., Caton, J., Henderson, C.M., and Koud, R.E. Oepaattion and Dist~bn of 7otal Particular Matter In BC3F1 mice Af~ar E~o~xe to Cigaretle Smoke. To~o~iqy & Applied Pttiarrt~ecc~y,~,1979. Henry, C.J., Avqry, M.D., Dansle, D.R., Lopez, A., Broth, LA., BllI~, L.H., and Kour(, R.E. The Effect ofEx~ ure to Whole Cigarette Smoke on 2-MelhybTqlanthrer~e (MCA) 1ndkmd Lung Tumors in BC3F1r,,um Mioe. Proc. Am. Assoc. Carber Res., 21:128,1980. Henry, C.J., BIIlups, LH., Drnowttz, M., Rasmussen, R.E., Ave~, M.D., Dansle, D.R., Lopz, A., Breth, LA., Mutl~nax, H.D., and Kourl, R.E. The Effect of Evosure b Wtaie Cfsarette Smoke or~l F'~ulrranary Mixed Funcdon Oxddaee, C~rnithine Decarbo Ase DNA Repair Capadty and on 3-Methyd~olanthrene (MCA) ) Bavarta, Fedeal Ru ~i3 of C3, F~YnMloe. ~yrr~poskxn on Carck~oflenesis and Blomarkers, p.56, es01 Sctrechtman, L.M., Divey, C.A., Kbs,E., Curren, R.D., Putnam, D.L., Lubet R.A., and Kourl, R.E. Induction of Morphologiral Transformation of C3H3H 10H 10T 12 Cbne in the Presence of Exogenous Metabolic Actfvation. Proc. Am. Assoc. Canoer Rea, 21:128,1980. . Okvwttz, M., Nkns, R., Shooshan, R., Kourl, R.E., and Henry, C.J. inductbn of Ornithine Decarboxylase (ODC) by 12-0-Tetradecanoylphorbol-13-soetae (TPA) In Pulmonary Tissue: A Model System for Tumor Promotion in mouse Lungs. Proc. Am. Assoc. Canoer Res. ~~1,1980. Henry, C.J., Whitmire, C.E., Lopez, A., Dansle, D.R. Avery, M.D., Csbn, J.E., Henderson, S.M., Sbkely, J.R., Ouerln, M.R., Curren, R.D., and Kourf, ~t.E. Dislributlor~ and Clearanoe of Three Cigarette Smoke Constttuertts, Dotriaoontane (DTC), Nicotine (NIC), and Benzo(a)pyrene (BP) After Exposure to Mice b Whole Cigarette Smoke. The Toxdoologist, 1:139,1981. kourlr.Qsmart.n.t 410-6.11-Ot26 410-531-W2!(FAX) I ) ) CTR MN 04'3658

Henry. C.J., Colins, M.R., Hall, W.C., Putnam, D. Lubet, R.A., Dau~sle, D.R., Avery, M.D., McKlnney, C.E., and Kourf, R.E. ENsds of Sendal Vkus and ~aodne on Short Term Toxbobgical and imn'xx)ologk*! Mericers In Strdn IVJ Mioe. Am. CopeQe Vet. Path., P.12T,1681. Kanagalisgam, K.K., Reed, B.M., Darm{e, D.R., Hall, W.C., Kourl, R.E., end Henry, C.J. Aubradiographlc Mafysta of ONASmtiesta In Pulmonary Tlasues of Mioe EVosed to Who4e Cigarette 8moke. ''he TO*o10*t, 2:48,1B82- Schect*=, L.M., Klss E., McCarvlN, J., Q ~r M., Kouri, R.E., and Lubet, R.. A Method br ~R1mpl ~of 8er~1ltv~ty of the C3H t OT 1~t Cel frarrelomtiatlon Assay. Proc. Am. Assoc. Canosr C3H 10dT 2 T.M.ranatormatlo~r~~~yEnhanoes Its a, Senstd~ty boRDlverae Chemk~i Carcinoqens. 13th Inlemafbnal Cancer Congnsse,1982. Kourt, R.E., McKkx*y, C.E., Sbm , D., ~St ~~ r~asa„ W.N., and MoLemore, T. Posltlv+e CorTelatbn .HI~ kMamallor~aTCar o r ~ Et2 1'~/°r~oxy1ae^^^) Ac~tlvtty and Primary Lung Cancer In Humans. 13th Lubet, R.A., ConnoNyC, 0., and Kourl, R.E. The MetaboAsrn of Dtbenz(a,h)anthraoerre (DBA by Mouse Hepntic Maosomes and its RetaSonehlp to DNA-Mduoed Tumor Formation. Proc. Am. Soc. erbmentat 8b1., 414, 1982. 10 Kourl, R.E. Corx~oNy, G., Nebert, D.W., and Lubet, R.A. The Metat~oNsm of Dibenz(a,h)anftxaoene (D 8A)by N~ouse NMcrosomes and 1ts Retalbnship to DBA-Induoed Tumor Fortnatlon. Proc. Am. Assoc. Canoer Res., 23:10,1982. Schecfitman, L.M., Gallagher, M.A. Henry C.J., and Kourl, R.E Induction of Neoptas5c Translormatbn and Single 8trand DNA Breaks In H 10~' 12 CeNsby l~cydio H ns and Short Chain Aricytattng Agents. Proc. Fed. Am. Soc. for Experimental Bb pism, 641,1982. , K.K., Sonko, 0., Danale, D.R., and Kourl, R.E. Studies on the Disposition and Dtstrtwtbn of from Whole Cigarette Smoke In BC3F1/Cum Mbe. The Toxbobglst, 2:46,196'L. arx! Kourf, l~.~E. Tfie Ef~aec~ Of .K., ~~Whole C~, ~. on .ortb9T~ , E R.nafpoints 1~" W., 8C3F1 /Cum Mioe. Proc. 13th Inbema5onal Cancer ~~, 61, 1982. Hwang, K.K., Sonko, 0., Dansie, D.R., H , B.S., Kouri, R.E., and Henry, C.J. fdentlficatbn of A Urinary RCatechol egionel M~eetlr~i0. Proc. A~rrm. Chem~. Soc.fep 74,1g62,Whole Cbareffe Smoke In Mice. 16th Mid- Levin, A.S., MdQnney, C.E., EcheberQer, C.K., Kourl, R.E., Edwards, B.K., and NebeM D.W. Aryl ~~~' ~~ Ry~MrorqNPrirrtary RetaSves of Children with Let~icerr~ia or Soifd Tumors. Lubei R.A., Taramell, D., Brunda, AM9.,, Dansle, D., Nebert, D.W., and Kouri, R.E. The Role of AHH Inducibility In Determininp Immunoto~ddty Induced by the Polyr,ycNc Hydrocarbons. Symposium on Polynuclear Aromatic ~s. Oc~ober 1983, Columbus, Ohio. Kouri, R.E., McKinney, C.E., McLemore, R.L., Levine, A.S., and Nebert, D.W. Assoctatfons Between E~~gen MetabONsrn and Canoer Susoeptlbikty In Humans. 2nd International Meeting on Genetic ion and Ced Transformation, Ocbber 12-15, 1983, Albhero, ttay. HLaboralo ~New Yorfc. 81h* 8a~d ry 8ym~po~um, 6cb 12-18,1983, Coid~Spring~Ac~vvated ry Curren, R.D., Lubet, R.A., Kotxi, R.E., and Y , L.L. Hepabc,yee-Medle~~ed of Normal and Repair DeAdent Human CeMs. Env4ron. Mutapenesia~459, 1984. Kourt, R.E., Lubet, R.A., Tu, A., .lones, C. and Huberman, E. Transtorrnatbn Sb,dies with Cryopreserved Syrian Hameter Embryo (§HE) Ceile: An Inberiaboratory Comparison. Proc. Am. Assoc. kourtrsOsmart.nst 410-6,l1-OW 414-,6.31-MNFAX1 CTR MN 04,3659

Cancer Res. W137,1984 Kourt, R.E., Oenetlc Control of the Toxic Eftects of Tobacoo Smoke Exposure. Internatf.onal Agency for Research In Canoer. January 23-February 2,1985, Ly+orra, Franoe. , MoCarvlt4, J., Lubat, RA, Schiechtman, LM., Kouri, R.E., and Putnam, D.L Morphobgicaf Trarsliormation of BALBI3T3 CeN Usk>D Dimethylnltrosamine and 2-NapMhyl amine In the Presence of a Rat Uv+er S-9 Activation System. ErMron. MutaQenesis: Z: 28,1986. Curren, R.D., Cflnklin, P.M., Stampler, M.R., Rt>;m, J.B., Kouri, R.E., and Yang, L.L Evaluation of : Human Eptthelial-Derfrred Cell Unes as Potentlal Targets In Genetic ToxfooloQy Assays. Environ. Mutapenesls ZS2,19e5. Kourt, R.E., McLemore T., Jafswal, A.K., and Nebert, D.W. New Chemk;al Assays for Drua/Cardnogen Metabolism-Impac~ of ~Vbiecuiar BlobQy. 50th Tltizee Conferenoe, Boerhqher-Ingleheim ~und, Tihzee, ODR. Ocbber 12-15,1885. Eubar*s, J. 8mfth, B. Wasmuth, J., Kourl, R.E., Brown, J.H., and Evans, O.A. Mapplng of a Conserved b Proieh~oupled Reoepbr-Mke Oene on Human Chromosome 19. Human Gene Mapping- 10, Cy00penet Ceil Oenett fd:985,1989. Pascoe, L., Kaxt, R.E., and Whtie, P. A New Gene Famliy on Chromosome 5. Human Gene Mapping- 10, Cylogenet CeH Genet fij:1058, 1989. 16 Kourl, R.E., Lewis, M.E., Baricer, D., Dfetz-Band, J., Ng K., Mclsmore, T. and Wasmutti, J.J. O~ e~e ng-~t 0n~ Cel~l Oe fth et ~Ilvalla~ble Somatic trell Hybrid Panel. Human , Kourl, R.E., Lewis, M.E., Ruano, O:; Hozier, J.C., Oreen, E.D., Weber, B. Hayden, M., and Weber, J.L Use of DNA from a Commerdally-Avaltable Somatic Ceil Hybrid Panel as ~'CF# Ternplates br Ctwornosorne Locattzafion. Hurnan Oenorrre 1,1999. Fain, P. and Kourf, R.E., Conatructlon and Use of Melodc Mapping Panels. Suboommtuee on Mapping Chromo®ome 17. Park Cky, UT,1990. Fain, P. and Kourl, R.E. Charactertzinp and Using Mebtlc Mapping Panels in'Oenorttiic Mapping and Sequendnp'. Cold 8pr~ Harbor Press.1990. Lewis, M.E., Kour1, R.E., and J.L. Kennedy. Cross-spedes Conservatbn of a Human Mttroct~ondrlat Sequence. Am. J. Hum. t~e/~et. ~: A187,1990. Kourl, R.E. and Fain, P., Constructbn and Use of Mebtlc Mapping Panels. Am. J. Human Oenetics, 4Z: A1®6.,1990. Kour1, R.E. and Fain, P., Melotb Mapping Panels for: An Efflc{ent Strategy for Genetic Mapping. Human Genorne 11,1990. Lewis, M.E., Ruano, O., and Koud, R.E. DNA Arnpliffoatlon and Labeling from Targets of UnknoMm Sequerxoe. Human Oenome 11,1990. Lane, J.J., Manbe, 8., Hahn, P.J., 8mardon, A.M., Hanbn, D.J., Waterbury, P.O. Carroa, W.T., H ~y, C.B., Kour1, R.E., Faldasz, B.D., ScalzI J.M., and Hoiier, J.M. Rapid ~onstruction of l.ow R~sol ~fi on Human Chromosome Maps:1`he Order of'Alu-Rkh" Not I Frapments Spamng Chromosome 17q. Fkxman Oenortw 1,1990. Lewis, M.E., Ruano, O., and Kouri, R.E. Gydizatbn of Random Prlming Reac-dons for PnQbe Labeling and Syntttesls. Am. J. Hum. Oenet., 4$: A1081, 1991. Kouri, R.E., Jarvis, J., Kldd K.K. Lewis, M.E., and Fain, P.D. Meiotic Mapping Panels: An efficient strategy tor genome mapp~r~. ~ybQenet. CeN Genet f@, 2008,1991. Kouri, R.E. Kldd, K., Lewis, M., Fain, P., Meiottic Mappinp Panels: An Efflcient Strategy for Cienorne Mappin~• ~yb0enet. Ceil OenetL f$; 2006,1991. Ruano, O., Kouri, R.E., Pagliaro, E., Lee, H., PCR Multiplex Typing of MiaosatelNte Lod: Applications to kourlroOsmsrt.nst 410•a.11-ie26 41Q4.11-OMFAX) ) ) CTR PIN 04366.0.

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- - - - . . ... ;c~ .._..-. . .._. . ~ .... ia_'..~._ ~ Kourt, R.E., and Coggin, J.H. Radiation sof Embryonal and SV40 Transformed Hamster Ceils in Cutture. Proc. Soc. E~. Blol. Mld., J2$RsBi~,1988. Kourl, R.E., Lubet, R.AA and Brovvn D.C?. In Vibro Cellular Uptake of Benzo(a)pyrene Measured by a MaoAuorome~6rtc Tectn~que. Proc. toc. E)q. Blol. Med., LV:10Ci8-1044,1971. Miller, O.J., MHec, D.A., Koud, R.E., Aiderdloe, P.W., V.Q., Grewal, M.S., and Hutbn, J.J. ideMtffcatbn of the Mouse'~ by Q~~inacrlne Fluorescence and Tentative Assignment of Seven Unkage Groups. Proc. t~le~. ~ 1530,1971. Kourl, R.E., MIAer, D.A., Mller O.J., Dev, V.G., Orewal M.S., and Hutton. klentMcatlon of Quhacrine IFluoresoone of Chroma9onre G~arryk~g Mouse Lk4cage broup 1 in tfie Gattanaoh Transfocatbn. ) Genetios„ 1Q:129-132,1971. MiNer, DA, Kourl, R.E., Dew , V.G. Grewal, M.B., Hutton JJ ., and Mi~er, 0.J. Assignment of Four Unkage aroupe to Chromoeorr~e In ~ and a G~ bQenetlc Mett~od tor Locating Thek ~ ~ Ends. Proc. Ne~t. Acad. Sd ,1707,19 1. Dev, V.G., Grewal, M.S., Miller, D.A., Kourl, R.E., Hutton, J.J., and M(Aer, O.J. The Quinacrine ~ Fluoresoenoa Kar~~C ~ and Demonstratbn of Strain D t~ferenoes In Secondary ~~~ , Conabfctbns. CYib .438-451,1971. M0ler, O.J., MRbr, OJ1., Kouri, R.E., Dev, V.G., Grewal, M.S., and Hutton, J.J. Assignment of Unkage Groups VilI and X to Chromosomes In Musculus and Identification of ihe Cen tromertc End of Unkape , Group 1. Cylbgenetoe, JQ:452-484,19 1. i Kourt, R.E., Lubet, RA, and Brown, D.Q. QuanUtatbn of i Hyd rocarbon Hydroxylase AcUvfty In hxtvfdual Hamsiber Fetal CeNs In Vitro. J. Natl. Canoer Inst., 9W-1005,1972. Thomas P.E., Kourt, R.E., and Hutton, J.J. The Genetics of ArytHyd n~carbon Hydroxylase Induction In 1t A§tnpte Gene Differenoe Between C57BU8J and DBA~aJ. Bloct*mlca! Genetics, fi:157-188, MiMer, D.A., Aldenfioe, P.W., Kouri, R.E., Dev, V.G., Grewai, M.B., Mi1er, O.J.; and Hutbn, J.J. Quktacrirre Fluorescent Chromosome Analyab of the Snell Transbcatlon in the Mouse. Genetics 1Z:6363A,1972. The Transio~m~at W.F., anand d C~hrorrioeorr~al ChanQes In Hams~eretall-Cetis. Genetjcs, Z4~~1~ ~ 9~3.a~) Kouri, R.E., Salerno, R.A., and Whltmire, C.E. Relationships Between Aryl Hydrocarbon Hydro,cyt~,se Induclbility and ~ to (,'hemlcaMyInduosd Subcutaneous Sarcomas In Varbus Straktis of Mbe. J. Natl. Canoer bat. QQ28"@9,1973. Nebert, D.W., Benecxct, W.F., and Kourt, R.E. Aromatic Hydrocarbon Produced Tumorfgenesis and the Genetic Dtfterenoes In ,ryl Hyrr~ocarbon Hydroacytase IN: P.O.P. Ts'o and JA. DlPaob (eds.), Chemical Cardnogenee s, Part A,All~ar~o91-Deldcer, New Y rk, pp. 271-288,1974 Kouri, R.E., Ratrie, H., and Whlt,mire, C.E. Evidence tor Genetic Retationship Between 3-Methyctroianttxene-Induoed 8ubcutaneous Tumor and InducblNty of Aryl }ty~drocarbon~ Ffi b xylase. J. Natl. Canosr kat. A1:191-200,1973. Lubet, R.A., Brown, D.Q., and Koud, R.E. The Role of 3-0H-8enr.o(a)pyrene In MedfaftBenzo(a)pyrene-Induoed G~rbbxidty and TransiOrmatbn in Ceri Culture. Res. Comm. in Chem. Path. and Pharm., flV2t}-942, 1 739 U~d ~uoe .E.Suboutaneous~Sarcorna$kelntC. J..Car~oer,12:7~7208197~4~ to 3-Metttyichotartlhrene- Kour1, R.E., Kbter, R., and Zirrmerman, E.M. Hydrocarbon Metaboitzhp Acttvity of Varbus MarrxnaUan CeNs in Cula". In VIfro,1Q:18-25, 1974. kourlnlarnart.n.t 410-631-OM 41G-6S1-0f2d(FAX) ) ,-) CTR MN 043GG2

H+xnen, RLy~'~tx~x.~yeeHCuAlhj~ ~ 2,8,7~,8~- achb~rodbOenWzo-p db~Sder, ;i:1585-Ind 5~ n!n 1974. Kouri, R.E., Demobe, C.F., and Whltmke, C.E. The SIBnMfcanoe of fhe Hydrocarbon Hydroxyiase IN: E. Kerbe and ~ (e~ Ine imennl ~ng Cari S, a fV~Raspi Yor~k, ^4. J.F. Park ds.), a Exp s~ a0 New PP Demol9e, C.F., Kourt, R.E., and Wh#trNre, C.E. CeM-Medlated ImnwNty Affer Intratrect" Exposure b 3- ; Mett ene and lta Relertj.onahip b Tumor Transplant Qnowlh in C3H/f Mai Mioe. IN: E. Karbe and J.K. ark (eds.) ExPerimerrtal Lung Cancer, Sprtnper-Verlep, NewYork, pp. 72,1974. WhffmMe, C.E., Demolse, C.F., and Kouri, R.E. The Role of the Host In the Development of In Vftro Models br Carolnogenesfs Studies. IN: E. Karbe and J.F. Park (eds.), ExPertmentsl Lung Cancer, Sprinper-Vertep, NewYork, pp. 20,1974. Koud 3 , E.la~ntfx~ene In'Aa~E~yo G~eKit~ F~r~ wM ,uine Le~ulcemla Vkus~. Can.er~Res.Pe of 143, 1976. eenedict, W.F., Rudcer, M., Mnrk, C., and Ko~xt, R.E. Correlation Betw~een the Balance of Specific Chromosomes and the Expreasbn of MaNnancy In Hamster CeNa. J. Natl. Cancer Inst., ¢d:157-162, 1976. -0 Kourl, R.E., Kurtz, S., Price., and Benedfct, W.F. Studiee of the Ara-C-kxfuoed Transformatbn of Hamster and Rat CeNs In Culture. Cancer Res., 352413-2419,1975. ' Benedict 8.moke Cnde~ C, anoeAr~ReKs~u, 857-8~,19n7b T~~n of Mouse CeMs by C Kourl, R.E., Rude, T., Thomss, P.E., and Whitnke, C.E. Sbudbs onpuImpnaryAcytNydrooarbon HyOroxytase AcUvlty In Inbred Strains of Mice. Chem. 13101. Ineerlctlons, yAZ7-331, 1976. Kourl, R.E. Relafficnshlps Between Levels of Aryl Hydrocarbon ydroxytaae AcofMbe IN: lfirtty and Susoepdbitity of 3-Methybt~tanthrene and Benr~o(~ ICenoers In kt~xed S~reins Fredesrtt~al & Jones (eds.), Po~muc~ear ~IromaScpicarbons: Chemistry, Metabolisrn and Carolnogenesis, Raven Press, New York, pp. 139-151, 976. Nebert, D.W., Felton, J.S., Kourl, R.E., and Boobis, A.R. t3enertic Differences In the Bindi Symp. on the Dea) e~nd Prevention o ~ f C noer, IMa~roel-D~ek~ker,iNe wYoric,~pp~1~ 197 13th Intl~ of ~taction Burke, M.D., Mayer, R.T., and Kourl, R.E. 3-Methychotanthrene-induoed Monooxygenase (O- Deettrytatbn) Acttvtty of Human Lymphocytes. Cancer Res., $Z:480,1977. , R.A., Imdum, R.L, and Kour1, R.E. NADH-G~rlochnome 0 Reductase Actlvfty in Cultured Human x.'Ybes: Slrnflaft b the Liver Miorosomal NAD~-cvbdwome >z Enzmne System. Arch. 6bct*m. =:119,1976. - Kourl, R.E., Imbium, R.L., and Prough, R.A. Measurements of Aryt rocarbon Hydroxylase and H.ENleberM~PCroCy~3 d Ir~ttl. Synip~De6eend MP v~entbn C~anoerHumMeroLel~Deldc~~NewN: York, pp. 510,1977. Nebert, D.W., Booble, A.R., Yagi, H., Jerfna, D.M., end Koud, R.E. Genetic Differences In a)pyrene N~~~iogenlc rndex In Vitro and In the Mouse --Cybohrome P-450-Mediated Benzo a)pyrene wlfte Blndin8 to DNA In Vitro. IN: D.J. Jallow, J.J. Kocels, R. Snyder, and H. Vainio (eds.), Biological Reactlve InbermedtaM1es, Plerxxn Press, New York,1977. Nebert, D.W., Febbn, J.S., Kouri, R.E., and Boobis, A.R. (3eneflc Differences In Blndhp of ~~and~Preventjon o~f Cbar oarA, IMdr~oei Deidaer,INewl(or~c, pp.l~0ed.)~roc. 23rd fnti. Symp. on the kourlr.Oateart.not 416-651-9M 410-611-UZd(FAX) i..x f R i f N ~"'~'..'f' 3~'.~ ~"°..~ 3

t Kourl, R.E. and Nebert, D.W. Genetic ulatbn of Su9oeptiblflty to P*yc.yd{c Hydrocarbon-Indioed Tumors In the Mouse. IN: HH. Hlatt, J.D.1Natson, and J.A. Wtnsten (eds.), Orfgins of Human Cancer, Cold 8pring Harbor Press, pp. 811-8;i5,1977. Sohechtman, L.M. and Koud, R.E. Control of Ben:ro(a)pyrene-Inck,ced Mammalian Cell Cybtoxicdty, Sobe~s (ed~s.j,aP ogr~~tn~C3ene~c to~ElselNorth Hoi{andl Pr~,NevYork, VBridge of 2. pp. 307, 19n. ; Koud, R.E., and Schechtman, LM. In Vitro Metabolic Activation Systwm IN: J. Berky and P.C. Sherrod (eda.), In Vitro Toxicity Testln3, Franklin Inst Press, Philsdelpha,nsytvanta, pp. 423, 1978. Nebert, D.W. /Ufas, S., Ouerrttw, T., and Kouri, R.E. The Ah l~ocxls: Genetic Regulations of the - MetabolizePo Enzymes (~ ~ 389,1978. Fi P Hydrocarbons and fhe isk of Cancer. IN: O.P. Ts'o and H.V. Blology and Envlrorxnent, Academic Press, New York, pp. 345- Kouri, R.E., Rude, T.H., lekar, R., Dansetba, P.M., Jerlna, D.M., Atias, S.A., Owens, I.S., and Nebert, D.~~ '75uba~taureous Tumors in b C~ely~'Non-respo~~aNe' aatt~ie~3->s.y Ca ~~oer~Ree~s., 362777-2783, 1978. Kouri, R.E., Kurtz, S., Vernon, M.L Scheolrtman, L.M., Niotalson, M. Kleb~ent, V., and Benedict, W.F. C-Type RNA Vkus from Hams~r G~ells Transformed In Vitro by 1-B-~-Ardbinofuranosyfcybosine. Arch. of VirobQy, $Z241-252,1979. Kourl, R.E., Rude, T., Whttrnke, C.E. Henry, C.J, Sass, B., Bipups, LH. Correlation of In~duoibifity of Aryl Hyd~ rocarbon $ H~rd%xyfe~ae~~Mth ~usoeptlbiltty to 3-Mathyfoholanlhrene-hxhjoed Lung Cancer. Kouri, R.E., Imbkxn~, 7R-..B, •1SoenowW, R.G., Sbmimy, D.J., and IIAcKinney, C.E. Parameters Inik,endng the Quantltatbn of 3-lantluene Induced yIHydrooarbonHydr+oxy1~ Actlvity in Cultured Human Lymphocytes. J. nvfron. Pathobgy & ToxboloOY, 2:1079-10•88,1979. Bnemner, T., Reddy, P., Nayer, K., and Koud, R.E. Nucfeoside Ptaeptrorylase (NP-2) of Mice. BloohemiCAi GeneL 1$:1143-1151, 1979. Pelkonen, 0., Booble, A.R., Levltt, R.C., Koud, R.E., and Nebert, D.W. Genetic Dttfenenoes h the MetaboYc Actlvatbn of ap yrene In Mloe. Attempts to Con~elate Tumorioenesls wtth Binding of Reactlv~e Intertrsdlales ~ and wUh Mkutageriesis In Vitro. Phammoobqy, j$281-293,1979. Kourl, R.E., Brandt, K., Sosnowsld, R., Benedkkx„ W.F., and SoheoMman, LM. In Vitro Acttvatbn of etee Smoke Condensstie Matarlals to the Mutapenic Forms. IN: M. Waters, S. Nesraw, J.i. H ngh, S.S. Sandhu, and L Ctaxdon (eds.) APplicatbn of Short Term 8ioeesays In the Fractionation and Metysls of Compiex En~k+ocxnentsl kNxturea, Environmental Protectlon Apency, Research Trtungte Partc, Norfh Carollna, pp. 495-512, 1979. Legalor, M., Kourl, R.E., Pannar,/1.5., , S., PtN~am, D., Ledt, R., Hefclden, J., Meagher, J.F., Weaver, J., Kelly, N. Mutagenic Testln~ of~12 , 979~ine, Nftroethane and Diethytamine ~~ S Kourl, R.E., Rude, T.H., Curren, R.D., Brandt, K.R., Sosnovrski, R.G., Sofedttrnan, L.M., Benedict, W.F., and Henry, C.J. BbbQlca! Aceft of Tobacco Smoke Condensate and Condensate Fractions. J. Environ. Htth. Pemp6*oft 2JM-69, J.A., Joyner, J., Nayer, K., and Kourl, R.E. Genetics of Xenotnop~ Expression In Mioe: I. Evk NZBBI ~anad 129/J Sai .RJ.ro~bgy,~,~:7b8,19P 7 of In~ Virus In Crosses Invohring Koud, R.E., Schechtrnan, LM., and Nebert, D.W. Genetic Control of Cardnopen Metabollsm. IN: Genetic Difterenoes in Chemicaf Carcfnoqenesis. R.E. Koud, ad. CRC Press, Boca Ra1on, FbrSda, pp. 21-2$, 1960. kourlrs0emert.net 410-631-oi26 e10-s11-MdlFAX) ) CTR HN 043664

., &heChtman, LM., , C.J., and Kour1, R.E. E~e, Uptake and Distributbn of Chemical Cardens• IN: Qe~nets~ryc Dtfferenoes In Chemiced CarCk~ogen~esls. R.E. Koud, ed., CRC Press, Boca Raton~brida, PP. 1-20, 1890. Nayar, K., O'Ne6K, B., Koud, R.E. Inheritance of EndoQenous RNA Viruses. IN: Genetlc Dffferenoes In Cherrtcal Cardnopeneels. R.E. Kourl, ed., CRC Press, Boca Ra1on, Florida, pp. 93-128,1880. Kour(, R.E., Wood, A.W., Levin, W., Rude, T.H., Yaql, H., Mah H.D., end Jerina, D.W. A fs of the Subcutaneous Card,~le~dty of Benzo(a)pyrene and 13-BaF~ Derhrativvss In C3Hlf Cum Mice. J. Nat. ; Canoer k~st, ~~617 , 1990. Henry, C.J., Whttmfre, C.E., Lopez, A., Dansle, D.R. Avery, M.D., Curren, R.C., Ca1on, J.E, Stokely, J.R., Hoknberg, R.W., Guerin, M.R., and Kouri R.E lR~e Doskr~etry and D~Stributlon of e~teWtale Smoke Pa~,lales In Inbred Stratns of Mice. G~omparteon of a Large Smoke Exposure Machin.~SEM) with a SmaK Capactty Smoke Exposure Machlne (Watbn). Hanford Syrnposkxn Richland, Louislana. IN: Pulmonary Toxdoology of Respirabie Parfsctes, C.L. Sanders, F.T. Crosa, Q.9. Dagle, J.A. Mahafley (ads.), Tech. Inf. Ctr., USDOE, Springriefd, Vfrg4nla, pp.177-182,1980. Glatt H.R., 8ctiwlnd, H., SchedTtiman, L.M., Beard, k S., Koud, R.E., Zajdela, F., Crolsy, A., Perm, F., Jacquigran, P.C., and Oeach, F. Mutepenk~tyof G~ Relabed Carckagenic ~-Cardnogenic Compounds Various MetaboRizkg and ar~et CelEs. !N: Proc. tntematbnal S~r~po~urn of Short-Term Test Sysbems De1ec:~nQ Car~o~e~, K.H. Norpoth and R.C. Garr~er (eds.), Sprinper-V , Berftt, pp.103-126,1984. Cm, k~,Katy-In~du~o, edJA~Car~cer. C~ Res. R.43 4-X43~67,1980~~ Expression and Susoeptib~tty to Curren, R., Kouri, R.E., Kim, C.M., and Sthed*nan, L.M. Mutagenic and Carcinogenic Pobncy ior Exbracts from Diesel Related Envk+onmental Emissions: Slmukaneous Morphobgk;al Transformation and Mutagenesis In BALBk 3T3 Celu. IN: Health Effecft of Diesel Engine Emissions: Proceedings of an Irmamationai Symposlum, Vof. 2, W.E. Pepeft, R.M. Danner, anQN.A. Ctarke (eds.), pp. 861-873,1981. Rasnxjssen, R.E. Boyd, C.H, Dansle, D.R., Kourl, R.E., and Henry, C.J. DNA Repifcatbn and Unscheduled DN1 Synthesfs In Lungs of Mice Exposed b CiQarerie Smoke. Cancer Res., 412583- 2688,1981. Curren, R.D., Koud, R.E., and Schechtman, L.M. Studies fn MetaboNc Aafvatbn of Carcinopens for Cell Transformation and ~agenesis. IN: Mammalian CeN TrariBlormatbnby Chenkc~ IN: Advances In EnviraiRienfal ToxbobQyl9N-3541981. Dunkel, and M. Mefilrnan (eds.). Serwrb Press, Princeton Junction, New Jeroey, pp. 3 Henry, C.J., Caton, J.E., Smicety, J.R., Guerin, M.R., Lopez, A., Henderson, C.M., Gayle, T., Moneyhun, J., Whitrrdre, C.E., and Koud, R.E. ~ n and Distribution of the Total Particulate Matter of Cigarelte Smoke in Mice Using a Large Capadfy~~Smoke Expoaure System. Toxioology and Appiled Pherm., 5$399-409, 1981. Kourl, R.E., McK", C.E., andHexy , T.J. Genetic Control of Breast Canoer Susoeptibft In Animals. IN: Genetsc and Breast Cancer. H.T. Lynch, ed. Van Nostrand Reinhold Co., New York, pp.14-48, 1981: Henry, C.J., Biilups, L.H.a~Avery, M.D., Rude, T.H., Dansle D.R.,~~pez, A., Sass, B., Wi~itmlre, C.E., and Kouri, R.E. A Lurq G~toer Mode4 System Using 3-Met~yd~o~anmrene In Inbred Strains of Mice. Cancer Res., 41:5027 -5ai2, 1991. Kourl, R.E., ODerdorf, J., Sbrniany, D.J., and McK}rxtey, C.E. Aryi Hydrocarbon Hydroxytase Activities In Cryopreserved Human Lymptiocytes. Cancer Letters, JA:28-40,1961. Curren, R.D., Kouri, R.E., Kim, C.M., and SchecMman, L.M. Mutagenesis and ls Pobency and Mutagenesis BALBI~T3 Cetts. Er~nvift roEnmental I: nOemat. :f ~411~415,~~19p81~. ~ rnesls~r~~n , K.C.rt~Bho~a n, B., Koud, R.E., and Henry, CJ. Syr>tt~s of Trttlum LabeMed Catectiol. J. ~m~ X1X(1)25-38, 1981. kourlr. Asm&rt.nst 410-3,3141t2b 410-S31-ia2i( fAX) t.x f R f f f i 043665

Hwang, KK., Sonko, 0., Danafe, D.R., Kouri, R.E., andHenry , C.J. Studies on the Distribu8on and Caiachot fro Whole Cigarette Smoke In BqF1/Cum Female Mioe. To ApQlied Pt~am~eoobQy, ~:40b-414, 9821 Kouri R.E., , C.E., Siomiany, D.J., Snodprass, D.R., Wray, N.P., and Md.ernore, T.L. Positive Correlatbn Between High Mr( Hydrocarbon Hydrox~lase Acdvtt~t and Prknary Lung Canoer as Analyzed In Cryopreserv+e~ L~m~phocy~s. Canoer Res., ~S030-5037,1982. Henry, C.J., Hwang, K.K., Kanaoltngam, KK., and Kour1, R.E. Reoent Dev+eloprrrerrts in Inhalatbn To • Evaluatlon of Selecifed Short-Term Endpolnts Following Nose-Only' Exposure of Rodents . ' IN: Evaluation and ReOutatbn of Chemicals. F. Homburper, ed., S. Karper,.New York, pp. 233- 242, 1 Putman, D.L, Schechtrnan, LM., Curren, R.D., and Kotxl, R.E. Evakuaibn of Mutapenic and ' Cardragenic Polenrial Usirg Multiple aenstlc Endpoints In Cultured MarrKnaHan Celfs. IN: Safety Evaluation and Regutadfon 61 Cherhicals. F. Homburger, (ed.). 8. KarQer, Basel, pp.134-141,1982. Kourl, R.E., Blllups, LH., Ha1(, W.C., and Henry, CJ. A Mouse L.urg Car+dnorna Model System. Proc. of the 12th Conferenoe on Env(rorxnental ToHoiogy, AFAMRL-TR-81-149, pp. 35-49, 1982. Sdtiechtmen, LM., and Kourl, R.E. Corretatbns Between Mutapenesis and NeoplasUc Transtormatbn In In Vitro 8yslsms. IN: Envfrorxnent8l Mutagens and Cardr~rre . T. Supkrnua, S. Kondo, and H. Takebe (eds.) Un#v. Tokyo Press, Tokyo, pp. 209-218, 1882. ~ Schechtrnan, l.M., Lubet, R.A., Kouri, R.E. Stvalc, A., and Tu, A.S. Evaluation of the Transforrnation Assay~~ C3H 10T 12 Celts for Use In bcreer~inp Chemlcals tor Carcinogenic Potential. IN: Proc. 2nd NCVEF~AMIOSH Coliaboratfve Workstap: ProOress on Joint EnNronmental and Ooaupabonal Cancer Studfes. H.F. Kra , I.C. Blackw~ood, and TV.B. Frease (eds.). U.S. Govt. Printing Offioe, #381-132: ~~470,19~82. Putman, D.L., , K.T., O'NeUI, B., Reddy-Premkumar, E., Levy, J., and Kourl, R.E. Genetics of Xenotroplc Vkus essbn In Mice 11. Exfx bn of malor virus structural proteins In aosses v~ohrtnq NZ&BINJ, SW J, and 12Q/J strains of mice. Proc. Soc. Exp. Bfol. Med., =217-221,1983. Lubet, R.A., Comoly, G.M., Nebert, D.W., and Kouri R.E. Dbenzo (a,h)-arnhrooene-Induoed Suba~taneo«s Tumors in Mbe--Straln Carolrtogenesis, &$13-517,1883 Sensitivity and tthe Role of CardnoQen Metabolism. . Lubet, R.A., Connoly, G., Kourt, R.E., Nebert, D.W., and Blgekaw, S.W. The Biological Effects of the Sudan Dyes: Role of the ,&b CybsoNc Receptor. Bbchem. Pharrrtisool. 22W53-3058, 1883. Kouri, R.E., Connoly, G.M., Nebert, D.W., and Lubet, R.A. Genetic Linlcafle Between Su iUty b DiberuaMt~raoene-k~duoed Subcataneous Fibrosarooma Formation and the ~ Locus. Int. J~e~rcer 32:765-768,1883. Lubet, R.A., Klas, E., (3aAagher, M.M. Dhiely, C., Kourt, R.E., and 8chedtman, LM. Induation of H ~Transforrna~ ~~ ~tnale Strand Breaks In C3H t OT 12 Clone 8 Celis by PotycycNc ky(a8rg Apents. J. Nag. Cancer Inst Z,1,1983. Kouri, R.E., Lubet, R.A., McKkuney, C.E., CorxalN, G.M., Nebert, D.W. and Mxertare, T.L Aryl Hydrocarbon Hydroxylase Acthrfty--"Of Mice and ?iumans'. IN: Review of Biochemksl and Irpmunobg4c,al Mark+ers of idty Screentnp Tests. H. Miknan and S. SeN (eda.), Plenum PuWishing Co., pp. 179-197, 1 . Lubet, RA., Brunda, M.J., TarameMi, D., Dansle, D., Nebest, D.W., and Kouri, R.E. The Role of the Aryl Hydrocarbon Hydroxylase (AHH) Indudblllty in Determining Immunobxidty Induoed by the Poycydic AromaUc In "Carcirwgenesis--A CompreFwnsMe SurvW, Raven Press, New York, Vol. 9, pp. 25,5- , 1984. Yang, LL, Kouri, R.E., and Cixren R.D. Xeroderma PiQmenbsum Fibroblasts are More Sensittve to Asbestos Than are Nornned Hurrtian Fibroblasts. Carckioqeneals, 8291-294, 1984. kourl r. dlsmut.n.t 410-681-OfZ6 410-631-Oa2alFAX) ) ) CTRNN 04'3666

I, Sc~ectrtrnen, L.M., Lubet, R.., Koud, R.E. Slvak, A., and Tu, J1.S. Further Evaluatbn of the Transtormatbn ~~ C3H 10T 12 s for Use In Screening Chemicals for Cardnogenic Potential. tlal. Proc. 3^UERA1NiOSH Collaboratlv~e Workstwp: ProQress on Jokrt Env. Canoer Studies, Benedict, W.F., Banerjee, A., KenaBaNrgam, K.K., Dansie, D.R., Kourf R.E., and Henry C.J. Increaeed Sister C ~ 1change In Bone Marrow Celfs of Mice Exposed b~IVhole Ciparette S~nake Mutatbn ; Levine, A.S., McKinney, C.E., Eahelberger, C.K., Kourf, R.E., Edwards, B.K., and Nebert, D.W. Aryl rocarbon THud~ Ca~Hy R ~~'Ity~ Primary Relatives of Children with Lsukemia or Solid Kourl, R.E., Levine, A.S., Edwards, B1.K., McLemore, T.L., Vesaeil, E.S., and Hebert, D.W. Souroe of Inlerindtvfdual Varlatfons in ArylHydroceubonHydroxrylase In Mllopen-Actlvated Human Lymphocytes. IN: Report #16, Qenetic Varfabllfty In Responses to Chemtcal Exposure. 0. Omenn and H. t~~.j,. Cold Spring Harbor Laboratory Press, Cold Spring HBrbor, New York, pp. 131-144, Kourt, R.E., Mdqm , C.E., Levkne, A.S., Edwards, B.K., VesseN, E., Nebert, D.W., and McLemore, T.L. Variatbne In Aryl Hy~ XyIaq@Acttvtt4es h M~byen-Act*vvated Human and Non-human Primale Lymphocybs. Tokboi~Path ]2:187-197, 1984. Henry, C.J., Oayle T, Florant, L, Dansle, D.R., tireenspan, J. Ouerin, M Holmberg, R., Kanagalingam, K.K., and Koud, R.. Cfxonic Inhalation Studies in NMoe: I. Fadlftlea and c~n ior Nose Cny Exposure to Clgarette Smoke. Beltr. TbaMorach. Inlernatbnal, 9:18-31,19~: ~ Lubet, R.A., Brunda, M.J., TararnetY, D., Dansle, D., Nebert, D.W., and Kourl, R.E. kxducbon of knmunoeoxfdty by Polycyci'ic Hydrocarbons: Role of the 6b LeoaW Arch. Toxdool. f$:18-24, 1984. Hatich, O., Anderson, T., Schectrtman, LM., Lubet, R.A., Putman D.L, Kouri, R.E., Nhts, R.W., Camenon, J.W., S~6;etfs d~g , J.M., arid Tennant, R.W. Chem{ca1 Er~anoement of DNA Virus Transformation of Harnsier En~bryo: kftrtaboratory Testing of 12 Dhrerse Chemicals. Environ. Mutap. $:515-531, 1996. Schecht~M~ man, LM., Hatch, O.a., Mderson, T., Putrnan, D.L, ICourl, R.E., Cameron. J.W., Nirr~s, R.W., 8pa1din8, J.W., Terx~ant, R.W., and Lubet, R.A. Analysis of the irtbsr- and Intra-Leboratory Enhanoement of Slmlan Adenov~rus SA7 Trar~lomtiatfon ot Syrlan Hamsler Embrya C~ 5 a cinogenfc and Non-Cardragenic Compounds. Environ. Mu#eA. ~:498-514,1986. Tu, A., Hallowell, W. Pallotta, W., Sivak, A., Lubet, R.A., Curren, R.D., A , M.D., Jones, C., Sedita, B.., Huberman, E., ~Ternant,R., S~, J. and Kourl, R.E. An k~0erlabora~~~ory C~n of Transforma8on in Syctan Hemate r Ceils Using Model and Coded Chemicals. Mutag. 11:77-98,1988. Kourl, R.E., Mcl.emore, T., Jalswal, A. and Nebert, D.W. Current Cellular Assays ior Measuring Clinical In eectlons 1o I~ ~and XenoW~otk:sof Kalow, Qoedde, end ~ Techniquse. IN: "Ethnic Dft6erenoes Agarwal (eds) Alan R. Llss, Inc. New York, pp. 453-588, 1906. , C.J. and Kourl, R.E. Chronic INhalation Studies in Mice Ii. The Eflecxs of LorQ-Term Exposure of 2R1 IQarette Smoke on BS3F1JCum Mbe. J. Natl. Canoer Inat. a220C1-212,1888. Lubet, R.A., Nhns, R.W., Klss, E., Kouri, R.E., Putnam, D.L., and Sched*man, LM. Influence of Various Parameters on Benzo(a)pyrene Enhanoement of Atlenovius-SA-7 Transformatleon of Syrian Hamster Embryo Cels. Environ. Mutag. 8M30542,1988. Schechtrnan, L.M., Kiss, E., McCarvel, J., Nims, R., Kourl, R.E. and Lubet, R.A., A Mett~od for the Ampliflr~,ation of Chert~lcafy-Induoed Transtormation In C3H/10f 12 Clone 8 oells: Its use as a poterrtlal saeening ess8y. J. Natl. Cancer Inst. jg:487-498, 1987. Hurd, S.M. and Kourt, R.E. Patlartt A MeOad endApparatus for Mo{din8 Thin Gel Slabe Horizontally with IntegraNy Molded Large Volume Sarnple Wells. Patent No. 4,785,541, January 3, 1989. kourlr. Oamart.n.t 410-0.31-OZ8 410-3S1-0e2i(FAX) CTR NN 043667

No. 4,,818 .,960. Aprll 4R E9.~Palent. Mett~od and Apparatus for Blottlr~ from Etectrophores#s Gels. PaDant HurC, S.M. and Kourl, R.E., Patent. Method ofHarKthg and Trarqporting a Transfer Membrane Used In a Bbttlng Apparatus. Patent No. 4,812,216. March 14-, 1989. .11 Lewis, M.E., Kouri, R.E., Laiorra, D., Berka, K.M., Lee, HC.`and Qaenssfen, A.E., Restriction FraQment Length~ ~ ph DNA anaysEs by the FBI l.aboralory Probool using a simoe hardware System. 1990. Hurd, S. and Kourf, R.E., A Mettwf for Mokilng Thin Gel Siabs HortzotitaNy with Integraity Mo{ded Large Volume Sarroe Weft Patent No. 4,909,977. March 20,1990. Lewis, M.E., Kourl, A. E., Lalorra D., 8erka K.M., Lee H.C., and t3aermlan R.E. Restrictbn Fragment ~tsm DNAnalysts by ttre FBI t~.aborabory Probool usk~ a Simple Convenler~i ~ware J. Forex4c Sd. 351188-1190,1990. C.8.i ~Vourniskis ~J of ~.R~~ W.T., ~ Wale /lrtaly sls rbury P.a ~ Kouri R.E. A Strategy for rtalysls AppliC., fi:151-158,1891. Lane, M.J., Waterbury P.G., Carrol W.T., Smardon A.M., Faldasz B.D., Monte S., Huckaby C.S., Kourl R.E.,i"., Variation in Genomic Alu Repeat Denstty and Basla for Rag-id Constructfon of Framework Phyglc~,al Maps of Human . Ctxomosoma, M: 348-357, f892. Ruano, 0., Lewts, M.E., and Kour1 R.E. Cyclized Primer Exlension: A Method for Simuttaneo«s DNA Redbiabeflnp and Syntheses from Temp(ates of Unknown Sequence. Anal. Blochem. 2U:1-6, 1993. Ruano, a. and Kouri, R., Coupte0 Amplification And Sequencing. Pa*A awarded, 1994. Sprinkle, T., Kour1, R., Fain, P., Stoming, T., and Whitney, J. III Chromosornal Mappinq of the Human CNP Gene Using a Mebtlc Crossover DNA Panel, PCR, and A11ele-SpectNc Probes. Genomics. l$,; 542- 545,1 A93. U, W., H aby, C., Kourl R., and Ruano, R., Human Genomic Characterization of a Novel Locus- Specific Re~petrove Sequence. t3enomlcs 28297-402,1895. Tombran-Tink, J., Mazuuk, K, Kourt, R., Chung, D., Unker, T., Chader, O., and Rodripuez, I. Cion*ng and MoieWar Characwzatbn of the Human Gene for the Neurotropilto Serpin PEDF: Conservation, Polymorphism and Herttabilltiyr Studies. SubcNtW,1998. Chol, J.Y., U, W-L., Kourl, R.E., Yu, J., Kao, F-T., and Ruano, f3. Vtrtual Mapping of Acute Phase R~sponse Fac~ or (APRF) b 17q21 based on Sequence Bbfnformarios of Mbrod4ssec.~led DNA.Genomics a8(in Pr~ E= 8wla 'C3enetSc Dlfferenoes In Chemical Cardnopene$Is', ed., R.E. Kourl, CRC Press, Boca Raton, FL, 1984. 'Health Effects of Pyrerre and Selec.yed Analogs', Committee on Pyrene and SelecW Anabgs. D'Mston of Mediced Sciences, National Research Academy, National Academy of Scienoe Press, 1983. , 'The Evaluation of the Car Risk of Chemicals to Humans - Tobaooo Smoking", IARC Monographs, Lm Franoe,1987. 'The Genetics of Mental Disease•, Health and Sciences Comrnur4Catbns, Washington, D.C., 190 i. Ws" - kourlr.0.mart.nMt 410-611-St2d 41o-ai1-M* FAX) ) , r ) CTR NN 043666