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Copy Fxh:b:+'s UNITED STATES DISTRICT COURT EASTERN DISTRICT OF TEXAS TEXARKANA DIVISION THE STATE OF TEXAS, . Plaintiff, . vs. . Civil Action No. 5-96CV91 THE AMERICAN TOBACCO, et al., %I. Defendants. 10 11 12 13 14 15 16 17 18 19 20 21 Baltimore, Maryland September 12, 1997 Videotaped deposition of RICHARD E. KOURI, Ph.D., A Witness, called for oral examination by counsel for the State of Texas, taken at the Harbor Court Hotel, 550 Light Street, Caucus Room, before Shari L. Nelson, Notary Public, beginning at 9:50 o'clock a.m. Reported By: Shari L. Nelson, RMR-CRR Riggleman, Turk & Nelson (410) 539-6398 RIGGLEMAN, TURK & NELSON CTR HN 04-3GS2

Richard E:: Kourl , 4230 Buckskln Lake Drivs - EIIIcott City, MD 21042 EtlUcatlon 1971-72 Post Doctoral Fellow Roche Institute of Molecular B1obQy, Nurisy, NJ 1968-71 Ph.D. Radiation Blology Unlvenllty of Tennessee (Oak Ridge National ~ Laboratory) , KnoxvNls, TN 1967-68 M.S. Radiation Virology Universtry of Tennessee, Knoxville, TN 1983-66 B.S. Microbiology Ohio State University, Columbus, OH Work Expsrlencs/Accompllshments 1997 May ` Pr.sld.nt, Chl.f Ex.mdvs Officer, VIMRx O.nomlcs, Inc., Naw York, NY and S.nlor Vice Prssldsnt, VIMRx Pharmac.uticals, Inc., Wi1minBton, DE • Manage the /ofnt venture between VIMRx Pharmaoeutkals and the Columbia Genome Center, Columbia University School of Medicine •"Organize, priorftlze and o.ommerctalize penomlcs activities (esp. In areas of cancer and neurologic disorders) using gene discovery and mutation analysis: and, furwtlonal analyses using ribozymes, transQenicJknookouta and bbinformatk:s. 1997 Jan-May Business Development Analyst, Office of Technology Licensing, The Johns Hopkins University School of Medicine, Battlmon, MD • Co-founded VIVEX Therapies, Inc. /oo-authored Business Plan • Organized and licensed technologies from Dept. of Pathology (Hopkins), NUID, NIH and Univ.of Virginia (use, of soluble oompiement ,.inhibttora and solubte transplantation antigen oo-nstnxts for the dinlcal ; manaqement of aNogeneic and xenoDeneio organ transplantation) • Orchestrated and Initiated Company contacts fo'r:flrst round funding 1994-9a Founder, Director, Chief Operating Offlcsr; Chlef Technical Officer and Senior Vice Praid.nt, Gsni Logic Inc., Columbla, MD • Incubated,validated and licensed Yab Unlvenslty-based technology ~. • Co-authored Business Plan / hired CEO / orchestrated road show and oompleted $10 M round of venture financing from consortium led by Oxford Bioecbnoes and Hambro Amefica • Supervised the evolution of the core gene display and transcription factor capture technologies from manual to automated high- throughput formats • Inftiated agreements wfth Yale Univen;ity, Univ. of MD Medical Center, Johns Hopkins Medical Center, U. Mass. Medical Center, Univ. of Colorado Medical Center, and 8aybr Cotleye of Medicine for accessing key biological materials and expert consultants • Evaluated and managed aNlanoes with National Center for Genome kourirsesmart.nst 410-6.11-S26 41a331-4e2e(FA)q C T R . HN• --0 4 -3 6 S:4'

Resources (Sante Fe,NM), National Center for Blologbal Information (Biethesda,MD) and Division of Computer Research and Technology (Beftsda,MD) for bbinfomnaths and statistical support 1995-96 Adjunct Assodate Professor, Department CNiutar and Molecular Biology, University of Connectlcut, Storrs, CT 1 g95-o8 Adjunct Resarch Professor, Department of Genetics, Yale University School of Medicine, New Haven, CT 1986-a7 Chairman, sIOS Laboratories Inc., Kew Haven, CT 1986-94 Founder, Director, CEO and Presld.nt, 8109 Laboratories • Generated over $7 M In private plaoement capital led by ICF Inc. Vlenna,VA, Conn. Innovatlons Inc. and the Ctty of New Haven. • Authored and awarded over $4 M In government grants and contracts • Managed research product division that averaged as0.6 M/yr In revenues over the psat ftve years • Uoensed products to Amersham Corp., Visible Genetk;s, SootLab and Toyobo • Managed three dlvislons totaling 1845 peepb 1986-89 Founder, Director, Director of Ressarch(psrt time), GenMap Inc., New Haven, CT • Co-autfiored Business Plan and generated $3 M In venture capital led by Oxford Biosdenoe, MVP and Ventures West. • Managed staff of 10 Induding 3 Ph.D.s 1983-86 Dlrector of Ressarch, International 81otschnologies Inc., New Haven, CT • Set-up Research and Development Division / managed 5 person staff • Authored and awarded $1.2 M In government research grants • Co-authorad prospectus for successful IPO 1971-83 Director of Research, Mlcroblofogicai Assoclates, Bethesda, MD • Managed staff of 60 Indudlrg 20 doctorate level Individuals • Authored and awarded grants and contracts valued at >$12 M Technical ExpertlseJAccompllshments • Documented expertise In molecular bblogyhnolecutar flenetlcs, tissue cutture, mutagenesis, carclnogenesls, Positional Gsne Analysis and Candidate Gene Analysis • Specific Interest in Funcrional Genomks as embodied In methods for display of gene ~ expression patterns and control of these patterns by transortption factors • Authored over 110 manuscripts, 70 abstracts,3 books and 5 patents • Presented seminars at over 100 national and International forums • Recent Past Member :'Immunology and Molecular Slofogy" SBIR Study Section, 1984-94 (Chatmian); `By-Laws C`~onxnlttee', Am. Assoc. Cancer Res.,1990-92; "Suboommtttee for Genetic Predisposition to Environmental Carclnogenesis', NSF, 1990-92; 'Search Committee for Blotech Center Director", U.Conn., 1994; Committee to Establish Policy for AcaderNc-Industry Relatfons", U. Conn., 1996; Steering Commtttee for the 8lotschnoloqy Center', U.Conn.,1995-96 • Present Member :'Flnanoe Commfttee', Am. Assoc. Cancer Res., 1994- ko ur1 rs A s ms rt. nst 410-01-4s2Q 41 a631-0Q2a( FIJQ CTR NN 043GS4

RICHARD E. KOURI 1972 Post Dociarat Fetbw Roche kwtltuAe of Molecular Biology, Nutley,NJ 1971 Ph.D. Untveraity of Tennessee, KnoxvNle, TN (Radiation Biology) 1988 M.B. University of Tennessee, Knoxvtrie,TN (Radiation Virobgy) 1966 B.S. Ohio State Univefslty, Columbus, OH (Microbiology) ~ 1997 May President, Chief Executive Officer, V1MRx Genomics, Inc., New York, NY and Senior Vice President, VIMRx Ptttvmaoet~tk~ls, Inc., Wfmingfon, DE. ManaaesCen~r venture between VIMRx Phamtie~oei~lcals and the Cokxnbia Genome , Columbia Unlverslty School of Medicine. Organizes, prioritlzes ~oortx bes awanics ~( in areas of carroer and ~ ~ r~ m gene ~ analysis; and, functional ueing rbozyrnes,iransQenicJlcradca~ts and biokHormatks. Business 1997 The M~~ Hopkins Unhreretty~of Msd~` Office Battl~moTechnology re, ~~~~ Co-fownded and a+5t~ored Bu~akness Plan for ~Van~e ~~. Organized and licensed fechnobflies from Dept of Pa~ ~olo~r (H~opktVMS nsrt ID~giH and Univ.of Vkflhia. Techrwlosjy was based ~olubleon soluble tra R%A= luxukm I arfuuert oonstuets br the otWcel manaQernent of abpene+c and w~rx~oer~eic~ fi~ tatlon. Orchestral ed and ktitJated Company 1986 -1997 ~x f~ratFounder, Chairman, BIOS t.abofaforfes, Inc., New Haven, CT, Consulted on overall strategy for company. Evaluated funding allbema5ves espedalfy h area of dei~~~b'p- lnp tecFmolopbs as separate oompanbs. 1994 - Dec.1998 Founder Chief Operating O(fber, Chief Technical Officer and Senbr Vba President 6" Logic, Inc., Columbta, MD. ManaQed day-b-day actlvttles of psr~y tt~at tnckuded Infiouse personnel, oubfde suboontracbrs, and reeearr~p e~anoas. Atthored end menled Technical Operatln~ Plan of R ~S1 OM~ ~ for novel ~~ ~ ~ for,g ~~ 1995 -1996 AdjUW Research Professor, D9parbrtent of Genetics, Yale , Unfverstty School of Medicine, New Haven rT., 1995 -1996 unct Research Pro4eseor, Deparbnent of Cell and.MoW" Biology, U of Connectfaut, 8iorro, CT. 1987 -1995 AdJunct Research Professor, Dep&vment~emb bgy and PuWic Health, Yale Untverstty School of Mediclne, New Haven, CT. 1988 -1995 Founder, Prestdent andDirecbr of Research, BIOS Laboratiorfes, Inc., New Haven, CT. Coordinatied all activities for yearty planningbjdgetary cycles. Authored and montbres Operation Plans kx three dtvlsions of company -- Productbn, Sales/Markefing, and uct Development SupeMsed ar ooNaboratora and r~epera In R & o laborabry. Responslbie 1or jolM dewebpment pro)ects~~ wfih oorporate dients, and pranls and oontracxs tor government-sponsored b~ research. ExQanded revenues by 90~61n each of the last twoy~ears people In oorr~pany. Ralsed mbd of 67 M{n placement funds for company. . kourl r.0 s mart.n.t 410-d.11-OW 410-611-4Q24lFAX1 CTR I-IN 043655

, InC. 8oobn, MA. 1987 -~s~ for bec~nlcd d ~ 0~ oompany for fkst two years and member of AdvisorydvWmp~{~r1dW~ COordhal9d propri9f3ry strategic pr~OpObr at10n for 9OV~@rnrTlent and nongovemment sponsors. Fiehped gerrerate .6 In venture tunds. 1954 -1996 Vioe Prestdartit, Dkeobr of Reeearch, Irriernatfoned 8bbadMbples, Inc., New Haven, CT. Aeeponslble for penersting new techniques and equiprnent In order to educate and support 1he rrwlea,Aar bbbgy comrnunfty Particular Intsreat is in the ~ of spedrtc genetic sequences and ~eir role in risk to p human dbord ers. Reeponeibie lor flow of Wormdon between it~e R & D div~ and oommeraal qpplicatlons. Co-&uftwed prospectus for sucoessful IPO. Ralsed addltlonal $1.2 M In grants and oonftft personaMy b fund toese actlvftbs. 1977 -1984 Vioe Presldertt, Direc.'br of Reeearch, ItAfCrobb Associates, Bethesda, MD. Respor>We for daY-b-daY management of 'rofeasbnals dist*utad Irft four teotm{ca! Divisions: To and Ntoiecular Bbbgy, Genedc To o~o~y,p1~ nostlc 8ervloes, and Services. R~b1e for oost~c~t safes wlt~iln these Wvblons and beMreen research and oommeraal Pt~r ~. R1o ~nt a~nd n~on ~maertt~aie~ts.YR~abed Wkeft h grante and oontr~ ac~a pereon~~)ty to fund theee actlvitles. ; 1979 -1984 Head, Division of Toxbology and itAofeWlar Bb , MicrnWobgic~l Associates. Responslble for day-b-day manaQernent of sevenb~rectsons and a total of twsNe proftesbrials. Coordnatbn and expansion of reseanch directions in ttre areas of short-term b o~obgy wd~o~ are prtme 0bjectives. The newer tectx~iques ses of moiecular bblQgy form t(1e besfa tor meetfrq these o*c,tlv+es. 1971 -1984 Head, Sectbn of Bbchemicd Ona~Ma+ob~l~~gfcal kxkjdbV n. Project arec.'br r+eapor~sble iorsApr~ sbnthis vfw and In vItro effec~s of eVosure b fe Wette amoke end cigarette smoke Oondensat9 maf9rial6 and the penelio control 01 susoeptbilky b chernicalfy- hckioed canoers in aneb. 1970 -1971 Post-cfodorat F.eNow, DRoche ir>s~h~ of BbbQy,I~lutley,~ Neovfv'breey. m~etabo~sm In mice geneft and c~ybQenet~meftadsafa~ r~r~~p qmelhe mouse o?xo using fkjoron'~e~ric, adiome~ric, penetic apprnactres. ~ Fund ratsing from venture sources, priva0e pteoements, research alftanoes, and grants and contracts fNrtt bOth flOVerrKfl9nt and OOfpOfatlon8. Propriesary protection strategies, haudinD patenb, oopyrighta and trade secxets, Functional Genomics in areas of display of gerte exPresslon patterns and control of these patterns by trartsaiptbn hrabrs Mettads relatlve to MoleaJar b~i~a1 yeft ar d~na! ~ Anal~jrsi,4, m~, cararagenesis. candidate Gene Molecutar genetbs of predispositbn b Canoeddegenerattve diseaees. CQen9tk diepnoeis In vivo and In vttro bAoobgbal bbaasays kourlr.*emert.nat 41Od31-" 410-a31-4S2d(FAX) i ) CTR MN 04,3GSG

: Lectures have been presented at over seventy natl~onal meetinQs and twenty IntemaHonal fa'ums. Pos Colfitveun y~Caflfomlavan~Fr~, E1~ectriDcrP r FFe9insl,, ~ 1~eseCocx~cil, ~~ Internatfonal Agency for Research on Cancer, areat Plains Coal Gasification Prn}eat, and bts commercial organizations. Commlttee member for Environment MutepenSociety, Tissue Culture Assodatbn, American Association for Cancer Research and AmeriCan Coll~w of b*oioQy. Revfewer for nine ; sclentlfb joumals. Stbe oommlttee member and reviewer for the Natiortial Canoer Ir>s'kils, Nafjonal tnstttule of General Medical Sclerroes, Small Busfness Innovation Research ProQram, Environmental Re Probectbn~~ger~cy, Electrfc Power Research kts~ule, The Cotxtod for Tobacco ®earch, and the Veteran's dmin _lstration. Member of p~ 'Health Effects of Poone ard Selected Mafop' Divtsion of Medical Sdences, NRC, NAS,1983. N of panel 'Applof 8bcherr" Marfcers In Risk Aasessment,' NIEHS, NIH,1986. Revlew board member of "C prrvsntbn Decision Point Commtttee; DCPC, NCI, NIH,1988 !01969. Co-Chalrpereon O~~aupi~Zinp ComrrtikDae of the American- Soviet Synlposium'aertietfc Approaches for DetemNnlnq Pre~lti.n to Mental Dtsease~s',1990. Chairperson of Immunology and Moiecular Biology 8tudy Sectlon, Small Business Innovation Research Program, NIH,1984 b 104. Member of'Byt.awa Cortxnlttee', Amerk~,en Assode5on of Cancer Research,1991-1993. Meber of't~egtslatlve Conxrttttee', M;eric~n Aeeodatbn of Cancer Research, 1992 - Present. Member of 'Flnanoe Comrr~tttee ", Arrtier{cen Assoolallon of Cancer Res,1 993 - Preserri. Member of'Sear~ch Cortmttlee for Dinodor of Bbtecfxab~y Center', oi~Connecticut, 1993 - 1994. Co-chakperson, ~Y Suboomn~tttae, Conn: T~u ~~,1995 - 1996. Member of UnMerslty-tndustry Inb9rac~on Co ~ofa 1 9.1988. Member of Board of SclenGfiC Cotmsebrs, ~ AmwScan Association for the Advanoement of Science American Association for Cancer Research American of To M~>ask~x Soaety o~r Microbiology - Human Qenorr~s Society for In Vftro Mat= Kouri, R.E., t..ubeL RA, and Brown, D.Q. Cellular Response to Benzo(a)pyrene Measured by a Mbro-fluorometrlc Technique. J. Cel1. Bio y, O:72a,1969. Kouri, R.E., lubet, R.A., and Brown, D.Q.Effects of X-rays on Uptake of a Cf*mfcal Carcinogen, Benzo(a)pyrene, In Individual Ce#s In Culture. Rad. Res. yWOb-5) 262-283, 1970. Brown, D.Q., Lubet, R.A., and Kourl, R.E. The Relationshlp of Aryl Hydrocarbon Hydroxylase (AHH) to Benzo(a)pyrene Induced Cylotoxlcity In Cell Cultures of Hamater Fetuses. Proc. Am. Assoc. Cancer Res. t~2(192) :50, 1971. Kouri, R.E., Lubet, R.A., and Brown, D.Q. X-Irradlatlon Enhanced Beno(a)pyrene Carclnogenesis. j,Q. Vft. Rad. Res., Q:(Cb-9), 1971. 8enedlct, W.F., and Kouxi, R.E. Are-C-Produced Trsrlsfomiatlon in Harnsfer Fe#al Celfa. Proc. Arner. Assoc. Cancer Res., J4:94,1972. Benedfct, W.F., Karon, M. and Kouri, R.E. Malignant Transforrnatbn Produced by Cybsine Arabinostde. Pediatric Rea, p.72, 1973. Meth , ychdar~re~roc. Xl. Irttsmational oCaf~oer C~orqr~bp.C77 1974 ~~ ~~ Koud, R.E., Whttrnfre, C.E., Benedict, W.F. In Vtvo and In Vitro Effeas of Clparetts Smoke Condensate Fractions. Proc. Am. llesoc. Cancer Rea, jj:173, 1976. kouNr.6smart.net 410-351-S26 410-651-962a(FAX) CTR NN 043~'~57`

, Alfred, L, Torrafba, (3., and Kourl, R.E. Ary1 Hydrocarbon Hydro~rylase inductfon in Cultured Human Lymphocytes. Proc. Am. Asaoc. Cancer Res., ]Z:151, 1976. . Schechtrnan, LM., Iekar, R., Kurtz, S. Dtvefy, 0., and Kouri, R.E. Studies on Molecular Meohanlsms of 8enao a~)pyrene ( -Induoed Cybb*Ity and Transtormatlon Usinp SpeciAc Sources of Mixed Fur~ction a3daee AMAw Proc. AmAssoc. Cancer Res.,1Z:174,1978. Koud, R.E., McK", C., Sosrawsid, R., and Sctrechtman, L.M. Fadors Inlluendnq Aryl Hydrocarbon Hydroylsse (AHH) Aotivtty In Human Lyrnpho~. Proc. Am. Aseoc. Cancer Res. l@:150,1977. Koud, R.E., Jogsekar, R., and Schechtman, LM. Quantitative In Vttro Metabolism of Benzo(a)pyrene (BP) to Inlennedtatss Cybio& and MuWwic to Mammalian Cefls. Proc. 8th Mnual Meeting Envlrorttnental MuMpen Sodety, 19T)'. ,. Koud, R.E., Beard, S.F:, and 8ohectrtman, LM. Sirrultaneous Quantltatbn of Chemicepy-induoed Transiormation Frequency and Mutatbn F ~y of BALB/3T3 CeNS in Cut4~re. ProC. ~th Ar~nual Meeting of the Environmental Mutagen Society~.77,1977. Radtke, H.E., Rude, T., and Kourl, R.E. Evidence of Heterogeneity of Hepafic and Puknonary Epoxide Hydratase (EH) Actlvtty h Inbred Strains of Mice. Proc. Am. Aseoc. Cancer Res., l$:142, 1978. Bi9ups, LM., Hennr. C.J.,1Mhitrnire, C.E., and Kourl, R.E. PathoQenesla'bf Chemicaly-Induoed Lung lssbns in Mbe. P~r+oc. Am. Asaoc. Canoer Rea.,1fl:142,1978. ; ;, . T-, Lpf~octyeee.~Proc., Am~Aaeoc. ,Canoer R.,~18:74,197F8.~rocarbon Hydroxytase (AHH) in Human I~fuoed Ce~inoerd., PrEoc. A~m. S~oc., JM anbblo2p 7~'2N197 .E 8 and Susoeptibilky b Cherrdcally- Henry C.J., Bilkips, LH., Avery, M.D., Dansle, D.R.,l.opez, A., Broth, L.A., Rude, T.R., and Kouri, R.E. Lung 6anoer Model Systerns In lnbred Strains of Mice. Proc. Am. Assoc. Cancer Res. 29242,1979. Rasmussen, R.E.,8oyd, C.H., Henry, C.J., and Kourl, R.E. DNA Repair is Reduced In Lungs of Mioe Exlwsed b Cigareft Smoke. Proc. Am. Aseoc. Cancer Rea, 29242,1979. Hen , C.J.,Lopez, A., VIR~itrMre, C.E., Caton, J., Henderson, C.M., and Koud, R.E. Oepaattion and Dist~bn of 7otal Particular Matter In BC3F1 mice Af~ar E~o~xe to Cigaretle Smoke. To~o~iqy & Applied Pttiarrt~ecc~y,~,1979. Henry, C.J., Avqry, M.D., Dansle, D.R., Lopez, A., Broth, LA., BllI~, L.H., and Kour(, R.E. The Effect ofEx~ ure to Whole Cigarette Smoke on 2-MelhybTqlanthrer~e (MCA) 1ndkmd Lung Tumors in BC3F1r,,um Mioe. Proc. Am. Assoc. Carber Res., 21:128,1980. Henry, C.J., BIIlups, LH., Drnowttz, M., Rasmussen, R.E., Ave~, M.D., Dansle, D.R., Lopz, A., Breth, LA., Mutl~nax, H.D., and Kourl, R.E. The Effect of Evosure b Wtaie Cfsarette Smoke or~l F'~ulrranary Mixed Funcdon Oxddaee, C~rnithine Decarbo Ase DNA Repair Capadty and on 3-Methyd~olanthrene (MCA) ) Bavarta, Fedeal Ru ~i3 of C3, F~YnMloe. ~yrr~poskxn on Carck~oflenesis and Blomarkers, p.56, es01 Sctrechtman, L.M., Divey, C.A., Kbs,E., Curren, R.D., Putnam, D.L., Lubet R.A., and Kourl, R.E. Induction of Morphologiral Transformation of C3H3H 10H 10T 12 Cbne in the Presence of Exogenous Metabolic Actfvation. Proc. Am. Assoc. Canoer Rea, 21:128,1980. . Okvwttz, M., Nkns, R., Shooshan, R., Kourl, R.E., and Henry, C.J. inductbn of Ornithine Decarboxylase (ODC) by 12-0-Tetradecanoylphorbol-13-soetae (TPA) In Pulmonary Tissue: A Model System for Tumor Promotion in mouse Lungs. Proc. Am. Assoc. Canoer Res. ~~1,1980. Henry, C.J., Whitmire, C.E., Lopez, A., Dansle, D.R. Avery, M.D., Csbn, J.E., Henderson, S.M., Sbkely, J.R., Ouerln, M.R., Curren, R.D., and Kourf, ~t.E. Dislributlor~ and Clearanoe of Three Cigarette Smoke Constttuertts, Dotriaoontane (DTC), Nicotine (NIC), and Benzo(a)pyrene (BP) After Exposure to Mice b Whole Cigarette Smoke. The Toxdoologist, 1:139,1981. kourlr.Qsmart.n.t 410-6.11-Ot26 410-531-W2!(FAX) I ) ) CTR MN 04'3658

Henry. C.J., Colins, M.R., Hall, W.C., Putnam, D. Lubet, R.A., Dau~sle, D.R., Avery, M.D., McKlnney, C.E., and Kourf, R.E. ENsds of Sendal Vkus and ~aodne on Short Term Toxbobgical and imn'xx)ologk*! Mericers In Strdn IVJ Mioe. Am. CopeQe Vet. Path., P.12T,1681. Kanagalisgam, K.K., Reed, B.M., Darm{e, D.R., Hall, W.C., Kourl, R.E., end Henry, C.J. Aubradiographlc Mafysta of ONASmtiesta In Pulmonary Tlasues of Mioe EVosed to Who4e Cigarette 8moke. ''he TO*o10*t, 2:48,1B82- Schect*=, L.M., Klss E., McCarvlN, J., Q ~r M., Kouri, R.E., and Lubet, R.. A Method br ~R1mpl ~of 8er~1ltv~ty of the C3H t OT 1~t Cel frarrelomtiatlon Assay. Proc. Am. Assoc. Canosr C3H 10dT 2 T.M.ranatormatlo~r~~~yEnhanoes Its a, Senstd~ty boRDlverae Chemk~i Carcinoqens. 13th Inlemafbnal Cancer Congnsse,1982. Kourt, R.E., McKkx*y, C.E., Sbm , D., ~St ~~ r~asa„ W.N., and MoLemore, T. Posltlv+e CorTelatbn .HI~ kMamallor~aTCar o r ~ Et2 1'~/°r~oxy1ae^^^) Ac~tlvtty and Primary Lung Cancer In Humans. 13th Lubet, R.A., ConnoNyC, 0., and Kourl, R.E. The MetaboAsrn of Dtbenz(a,h)anthraoerre (DBA by Mouse Hepntic Maosomes and its RetaSonehlp to DNA-Mduoed Tumor Formation. Proc. Am. Soc. erbmentat 8b1., 414, 1982. 10 Kourl, R.E. Corx~oNy, G., Nebert, D.W., and Lubet, R.A. The Metat~oNsm of Dibenz(a,h)anftxaoene (D 8A)by N~ouse NMcrosomes and 1ts Retalbnship to DBA-Induoed Tumor Fortnatlon. Proc. Am. Assoc. Canoer Res., 23:10,1982. Schecfitman, L.M., Gallagher, M.A. Henry C.J., and Kourl, R.E Induction of Neoptas5c Translormatbn and Single 8trand DNA Breaks In H 10~' 12 CeNsby l~cydio H ns and Short Chain Aricytattng Agents. Proc. Fed. Am. Soc. for Experimental Bb pism, 641,1982. , K.K., Sonko, 0., Danale, D.R., and Kourl, R.E. Studies on the Disposition and Dtstrtwtbn of from Whole Cigarette Smoke In BC3F1/Cum Mbe. The Toxbobglst, 2:46,196'L. arx! Kourf, l~.~E. Tfie Ef~aec~ Of .K., ~~Whole C~, ~. on .ortb9T~ , E R.nafpoints 1~" W., 8C3F1 /Cum Mioe. Proc. 13th Inbema5onal Cancer ~~, 61, 1982. Hwang, K.K., Sonko, 0., Dansie, D.R., H , B.S., Kouri, R.E., and Henry, C.J. fdentlficatbn of A Urinary RCatechol egionel M~eetlr~i0. Proc. A~rrm. Chem~. Soc.fep 74,1g62,Whole Cbareffe Smoke In Mice. 16th Mid- Levin, A.S., MdQnney, C.E., EcheberQer, C.K., Kourl, R.E., Edwards, B.K., and NebeM D.W. Aryl ~~~' ~~ Ry~MrorqNPrirrtary RetaSves of Children with Let~icerr~ia or Soifd Tumors. Lubei R.A., Taramell, D., Brunda, AM9.,, Dansle, D., Nebert, D.W., and Kouri, R.E. The Role of AHH Inducibility In Determininp Immunoto~ddty Induced by the Polyr,ycNc Hydrocarbons. Symposium on Polynuclear Aromatic ~s. Oc~ober 1983, Columbus, Ohio. Kouri, R.E., McKinney, C.E., McLemore, R.L., Levine, A.S., and Nebert, D.W. Assoctatfons Between E~~gen MetabONsrn and Canoer Susoeptlbikty In Humans. 2nd International Meeting on Genetic ion and Ced Transformation, Ocbber 12-15, 1983, Albhero, ttay. HLaboralo ~New Yorfc. 81h* 8a~d ry 8ym~po~um, 6cb 12-18,1983, Coid~Spring~Ac~vvated ry Curren, R.D., Lubet, R.A., Kotxi, R.E., and Y , L.L. Hepabc,yee-Medle~~ed of Normal and Repair DeAdent Human CeMs. Env4ron. Mutapenesia~459, 1984. Kourt, R.E., Lubet, R.A., Tu, A., .lones, C. and Huberman, E. Transtorrnatbn Sb,dies with Cryopreserved Syrian Hameter Embryo (§HE) Ceile: An Inberiaboratory Comparison. Proc. Am. Assoc. kourtrsOsmart.nst 410-6,l1-OW 414-,6.31-MNFAX1 CTR MN 04,3659

Cancer Res. W137,1984 Kourt, R.E., Oenetlc Control of the Toxic Eftects of Tobacoo Smoke Exposure. Internatf.onal Agency for Research In Canoer. January 23-February 2,1985, Ly+orra, Franoe. , MoCarvlt4, J., Lubat, RA, Schiechtman, LM., Kouri, R.E., and Putnam, D.L Morphobgicaf Trarsliormation of BALBI3T3 CeN Usk>D Dimethylnltrosamine and 2-NapMhyl amine In the Presence of a Rat Uv+er S-9 Activation System. ErMron. MutaQenesis: Z: 28,1986. Curren, R.D., Cflnklin, P.M., Stampler, M.R., Rt>;m, J.B., Kouri, R.E., and Yang, L.L Evaluation of : Human Eptthelial-Derfrred Cell Unes as Potentlal Targets In Genetic ToxfooloQy Assays. Environ. Mutapenesls ZS2,19e5. Kourt, R.E., McLemore T., Jafswal, A.K., and Nebert, D.W. New Chemk;al Assays for Drua/Cardnogen Metabolism-Impac~ of ~Vbiecuiar BlobQy. 50th Tltizee Conferenoe, Boerhqher-Ingleheim ~und, Tihzee, ODR. Ocbber 12-15,1885. Eubar*s, J. 8mfth, B. Wasmuth, J., Kourl, R.E., Brown, J.H., and Evans, O.A. Mapplng of a Conserved b Proieh~oupled Reoepbr-Mke Oene on Human Chromosome 19. Human Gene Mapping- 10, Cy00penet Ceil Oenett fd:985,1989. Pascoe, L., Kaxt, R.E., and Whtie, P. A New Gene Famliy on Chromosome 5. Human Gene Mapping- 10, Cylogenet CeH Genet fij:1058, 1989. 16 Kourl, R.E., Lewis, M.E., Baricer, D., Dfetz-Band, J., Ng K., Mclsmore, T. and Wasmutti, J.J. O~ e~e ng-~t 0n~ Cel~l Oe fth et ~Ilvalla~ble Somatic trell Hybrid Panel. Human , Kourl, R.E., Lewis, M.E., Ruano, O:; Hozier, J.C., Oreen, E.D., Weber, B. Hayden, M., and Weber, J.L Use of DNA from a Commerdally-Avaltable Somatic Ceil Hybrid Panel as ~'CF# Ternplates br Ctwornosorne Locattzafion. Hurnan Oenorrre 1,1999. Fain, P. and Kourf, R.E., Conatructlon and Use of Melodc Mapping Panels. Suboommtuee on Mapping Chromo®ome 17. Park Cky, UT,1990. Fain, P. and Kourl, R.E. Charactertzinp and Using Mebtlc Mapping Panels in'Oenorttiic Mapping and Sequendnp'. Cold 8pr~ Harbor Press.1990. Lewis, M.E., Kour1, R.E., and J.L. Kennedy. Cross-spedes Conservatbn of a Human Mttroct~ondrlat Sequence. Am. J. Hum. t~e/~et. ~: A187,1990. Kourl, R.E. and Fain, P., Constructbn and Use of Mebtlc Mapping Panels. Am. J. Human Oenetics, 4Z: A1®6.,1990. Kour1, R.E. and Fain, P., Melotb Mapping Panels for: An Efflc{ent Strategy for Genetic Mapping. Human Genorne 11,1990. Lewis, M.E., Ruano, O., and Koud, R.E. DNA Arnpliffoatlon and Labeling from Targets of UnknoMm Sequerxoe. Human Oenome 11,1990. Lane, J.J., Manbe, 8., Hahn, P.J., 8mardon, A.M., Hanbn, D.J., Waterbury, P.O. Carroa, W.T., H ~y, C.B., Kour1, R.E., Faldasz, B.D., ScalzI J.M., and Hoiier, J.M. Rapid ~onstruction of l.ow R~sol ~fi on Human Chromosome Maps:1`he Order of'Alu-Rkh" Not I Frapments Spamng Chromosome 17q. Fkxman Oenortw 1,1990. Lewis, M.E., Ruano, O., and Kouri, R.E. Gydizatbn of Random Prlming Reac-dons for PnQbe Labeling and Syntttesls. Am. J. Hum. Oenet., 4$: A1081, 1991. Kouri, R.E., Jarvis, J., Kldd K.K. Lewis, M.E., and Fain, P.D. Meiotic Mapping Panels: An efficient strategy tor genome mapp~r~. ~ybQenet. CeN Genet f@, 2008,1991. Kouri, R.E. Kldd, K., Lewis, M., Fain, P., Meiottic Mappinp Panels: An Efflcient Strategy for Cienorne Mappin~• ~yb0enet. Ceil OenetL f$; 2006,1991. Ruano, O., Kouri, R.E., Pagliaro, E., Lee, H., PCR Multiplex Typing of MiaosatelNte Lod: Applications to kourlroOsmsrt.nst 410•a.11-ie26 41Q4.11-OMFAX) ) ) CTR PIN 04366.0.

Forer~sic DNA An*ds. Proc. Am. 8oc. Foreneic Sd. 185. 1992. Cp~~~T., Kaxt R.E., Fain, P., Sbming, T.ar~Whttney ,eis ney, J III, Mappl the Human CNP Gene ushg #~ me 17-~iectAc Meb~c Breakpoint and PCR M~pii. Cold Sprlrp Harbor Press. 1 o (CAS) OF Mttrochondrlaf D-boptyrtwrpfitems in A~nerhdiau~a. Am. 8oc. Human t3enet. ~~. Ruano, G., Koux1, R.E., C3enom{c Coupled AmpNfoosMon and Sequendng (CAS), Cofd Sptnp Harbor Presa. 97,1993. Han, J., Kourl, R.E., Huokaby, C., Ruano C., M~piNfcatbn of Microdtssected Chromosomal DNA wift~ htgh CienorNc Frequencymr~ess. Cold ~prinq Harbor Press. 86, 1994. Ruano, 0., Kotxl R.E., SeQuerk*V ofJ Ezcrro di~y from C~errotnic DNA Na Coupled Annpffficatfon Sequer~dng (CA§). Proc. Am. Assoc. Canoer r Res. 35:6t1,1994. u W., Kourf, R.E., Rueno, Q., Random AmpNAed Pofymorphic DNA (RAPD) as a Tool In Human Gienome Andysis. Cold 8prhp Harbor Press.144, 1994. Chol, J., Li, W-L Teata, C. J., Kourl, R.E., Yu, J., Kso, F-T., and Ruano Q. Vkhie! Meppkp: omwlogies between cbnes ~nom band-apedf~c Micaodbsectbn Ubraries and C3ene batabases. Genome ~~d. and Ruano, G., KIdQ, J., KidO, K., so bne, J. Kou R.E, ~3enomic Coaxled AmpilRca~on and 244,1993. © Choi, J., U, W-L., Koul, R. E., Kea, F-T., Yu, J., and Ruano, a. LoosHzatlon of APRF b 17g21 by vlrtunl mappli J ng based~~seg~uendnQ ~ Ruano, H Qu., U, W-L, e-speclec mia~odtssected DNA cbrres and datebase homologies. m.IZ 188, ,~C. S., Chol, J. Y., Yu, J., Kso, F-T., Zetretrw, G., t~ehnach. H., and Kouri, A. E. R~~17q21 wHh P1 donea lsolabed with mlaodseec,ied DNA probes. Am. J. Hum. Oenet. AZJ1289,1995. Tech. l: p83,189b. kourlmfsmart.not 41t>-9S1-Of= 414-631-OMFAX1 C.r f p i"~. FIf"i 043661