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Jvne 3, 1974 Dr. Fre3dy Baubwrger Prasident a,nd Directer Bio-Reaesrch Consultants, Inc. 9 C6®erei.al Avenue Cambridge, )is.ssaohzsetta 02141 Deer Freddy: The mancsrript, Cigarette :moke Inhalation Stadies in Inbred Syrian Baasters by P. Bernfeld, F. Sambvrge.r ,ad A. B. Rusafield, prepared for the Battelle Seattle 8ys2+osium oa tal Re ira Csscin enesis and Bioes J1me 23 - 27, has been rerie+rod by ow staff scnd coasnltaats. C,, Contitct 30. 5• A composite of the suggestions and coreaents received follorst #1. Table I, first footnote. It is snggested that the l.ast three words be deleted since 'SsicroinYasire cancer" is not mentioned elsevbere in the tezt oar legends for figmres, nor in the opinion of the reviewers, is it svpported by exaainat3on of the illustrations. 2. Page 2, liae 8. The esposure•of six Rri-1  simultaneously is mentioned. It shouLd be borne in mind that the dosage of smoke received by an individual aaiasal nay be affected by the number being exposed, on account of differences in the rate of smoke chanber depletion and dilution of the cham- ber contents by COZ " other eshaled prodncts. 3. Page 2, line 21. Snoke dilution factor. It should be made clear that the dilution factor is an estimate only. Lea.kape, speed sasi efficiency of nixing aaoke and alr aixl other factors may introduce inacciaacies. Only direct aeasua•ement under operating conditions can give a highly r•eliable figtre for concentration of szoke at the point of insalation. 4. Page 3, line 2. This estiaate of saoke concentration received by hman smokers is a plawible estimate vhich probably lies vitb.in the range, but it anst be recognized that indiridual vasiations are quite large and there is ao established 'arerage' based on observations. 5. Yage 6, line 18. The term 'pseudoepith•elicmatous bp~perpla+ia' .+es questioned as to its appropriateness. k_ CTR hril COWIDENTIAL - PIINJE~GIJTA TOEACCLI LITIGATION .i CTR CQNTRACTS 005740 CMI'I ! ! J I~I 0I 1rr• (mn 80

i -2- 6. Page 9, line 9. It is suggested that tLe pbrise "consistent vith carciaam" be deleted as non-contributory. v/. Page 12, first paragraph. Until the relative dosages of amcte received respectively into various parts oi the respiratory tracts of the Bio 15.16, Bio 87.20 and other strains haye act3ssl]y been aeas;aed, it seems hazerdovs to conclu3e that ditfereaces in ; laryngeal response must be dne to ditfezeaces.in tissne snsceptibility. Strain differences in palnonary nxcbanicr roch as ti,dal tolnu, minute volume, respiratory rate and erpecially ability and inelin- ation to suspend respiration could affect saoke dosages in ps.ttl- cnlar areas. 8. Typogre.pbical notes: Page 1,;71me 2. "$ecanse" rather than "siace". Page 2, line 1. American nsage (as contrasted to British) is to spe17l almdnsa witboct an 1 before a. With due conalderation of these ccccients, ve find no objection to yoar publication of this paper in a_V reputable scientific riedita on the nsval scientific responsibility of the authors. Sincerely 7oars, RCH:gh Robert C. Fackett, Ph.D. Research Director cc: Dr. P. Bernfeld bcc: Drs. So=aa^s, Gesdne:, biessrs. Res,'Jacob, a.xA CTR PYJ COWIDENTIAL I P11 N45GUTA TDE4XGO l- I TIGArI ON . . .. CTR caNTRACTS 005741 r+f' TI 1 ) / l I •.d' 1+ L.J' 2M.i M.

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