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1 Nov(-mbcr 4, 1970 Mr. F•. A~ Vassallo HIi:UTES OF MF.F.TING TO DISCUSS RESULTS OF F.XPERIHEhfS WITH SMOKING DOGS CONDUCTED DY DR. OSCAR AUERBACH, - Office of The Council for Tobacco Research, November 3,'1970 A discussion was held preliminary to the presentation to be rade by Dr. Auerbach to the ^,obacco Working Group at the National Cancer Instituta on November 9, 1970. Present: 7tiG ParticiQants Dr. Charles J. Kensler Dr. Alex K. Speara Dr. Helcut`Wakeham Dr. Murray Senkua. ., Others Present: Dr. R. Fagan, Doctor of Veterinary Medicine, Pathologi;t and Virologiat - Philip Morris Mr. Alex Holtzman, Legal Department - Philip ?:.)rris Hr. Hall, Legal Departc,env - Philip Hcrris Mr. William Shinn - Shook, Hardy, Ottwann, Mitchell & Bacon (Law Firm in Kansas City, Hissouri) CTR Staff Present: Dr. tr•hn H. Kreisher Dr. 1'inccnt F. l.i santi Dr. Robert C. Hockrtt Mr. W. T. lloyt Dr. Shcldon C. Sor.n,ers, Chairman of the Scientific Advisory Board of the Council for Tobacco Research The c.edical people At the necting, naaely, FaEan, Kreish^r, l.isanti, I:ockett and Socsners, e-phasized the following points 4hich should be raised with Dr. Auerbach after his presentation at the N.C.I, on ,ovcat,cr 9: rLA1NTIr7A' [XNIAIT • C" G On,TC 0' //• . i;'''-'-•'^ WILLIAM C. LJ.ww-~ p- RtaOTCOs• rwor. Rcr.nTCR J C~m R ~`~~~ 0'~ .~~'r{

a ;tt.il.... Pat a porcly ,•:Iicil/sclcntific hasis, the l,cai;la is a pnor ;':oicc fnr the cxpc•riroc•nt at !:•ind. T:cc 1-c•ha.•inr of the cc•11s in thc lun;;:: n:ac; thc hrc•athinC c':arectt•ria:tics of the boacles (doi;s) are so tatally r!iffc•r.:nt frc•T tjiosc of iran that any r.•cults nbtain,d are subjc•ct to sc•ticus qucatican. 2. Smokin; Tcchniques Dr. Sor~r,ers uas extrerely critical of the severity of thc crr.oi;ing techniques; first, thc :urrcries on the tract:cas and then the iuscrtion of plastic smoking tubes into the incisions no doubt were disturbing to the ctogs. These conditions probably caused chronic infections, hemotrhaEtr•g, welling of tissues - just a whole host of traur..atic and da:+:aginb cxprrienccs. It was rcpofted that the dogs were docile and friendly and appcared to enjoy the snaktng. This is a miainterpretatton; in the desire to please, the dogs covered iip the stress rnd trauma. In Dr. Sommers' opinion, the alleged Eo-called ill effects of the smoking may be attributable to ths stress and traums. The other r,edical people agreed with Dr. Sor.n,ers. 3. Exam(nation of Presumatal Cancerous Tissues In the several presentations which Dr. Auerbach has made regarding the experiments, he has shown slides of what he maintains are cancerous tissues. Tn medical terms these are referred to as squamous cell carcino.ma. In Dr. Sorrmer's' opinion, the photographic quality of the slides is unbelievably poor. He could not understand why Dr. Auerbach could not have employed the •rcadily available prof-ssional skill for the preparation of the slides. Purely on the basis of the quality of the slides, the interpretation is c.cani^gless, i.e., if the work is to be judged on the slides, then Dr. Aucrbach's c:erk is vorthlcss. Under any circumstances, only one of the slides suggests a carcinoma. None of the others could be regarded as cancerous. Dr. Soc-ners assucncs that it is because of the poor quality cf the slides that the JouiTal of the A.merican Medical Association has f:r.ally rejected Dr. Aucrbach's paper. However, the paper is scheduled to appear in ARC1iI1'ES OF EXl'IRO':'•!ENTAI• HEALTH, Vol. 21, No. 6, Deccr-.5cr 1470. According to Dr. Fagan.of Fhilip >!orris, so-.c 20 pat•`•oloLists throuohout t`.c t'nitcd Statcs vould not it the:;~sclvcs that Dr. has pre•'uced cancer in ciogs, as he clair..s. n'hile n:any of these pathologists i r•iy he a part of a.at one niLht call t:.e a;iti-to:.aeeo group, i:ecet`c'.css, • they sc:iously question Dr. Auerbach's conclu^ior•s. --- Murray Scnkus XS:has r:c: Mr. Cc1in S:c'Acs Dr. C. E. Tc•aguc tn Mr. V. S. Scri th, .t-• Dr. S. 0. Jones o ?:; • C. ?t. t: ~dc Dr. F. G. Colby .D ..D O w CTR MN ~..~'~ ~~ ~ ~

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