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PL AINTIFFS'•FXFI1gIT . OhTE ... RICHARM; STIREWAL . RFG. PRD£ OQUF3TREPORTER - '.1) One dog, which was an inveterate smoker, was placed in a stall to demonstrate how the animal smoked. • We used a University of k- .` . Kentucky reference cigaret. The dog's handler, Mr. David Ktrman, recognizea tne cigaret to ne stronger tnan tae Drana tney were using, and the behavior of the dog showed that he too was not used very restless, and salivated excessively. The amount of smoke could be regulated by the attendant by pinching off the tube leadtng from the cigaret to the tracheostomy tube. •:During the demonstration Mr. Kirman did this when the dog became cyanotic, obvious that the animal took between 20-30 shallow onea per cigaret. Counting the puffs the dog took and also looking at the records,: it was S:; to this kind of smoke. ~• ` Y_ ~: :._ . t The lighting puff was not given to the dog but was made by the pump attached to the cigaret holder. Thereafter the dog did its own smoking. . , . . .. . , . . - • . . . . . . . - ' • =`-~~• animal was in obvious distress... out of the dog's mouth and nose. There were moments when the 3) During the smoking period which lasted 8-10 minms smoke poured :; 4) Mr. Kirman states that there are 40 dogs still smoking and that•thc tests will continue. Judging the temperature of the smoke by feeling the tubing leading . from the cigaret to the hole In the trachea, I would say it wa~s tio higher than ambient. 100083'~391 pathologist, agrees with Auerbach's readings of slides. 6) Dr. Auerbach showed me photomicrographs of what looked to my non- expert eye as typical invasive carcinoma. He read m.e a report from • Dr. John Berg, N.C.I., which corroborates this diagnosis. Dr. Auer- bach showed me several notations In which Dr. S. Nielsen, veterinary 7) The manuscrtpt which had been read before a special meeting of the '; American Cancer Society has been submitted for publication. Dr. 'Auer- bach did not wish to reveal the name of the journal. As a farewell re- ~,. mark Dr. Auerbach wanted it known that he welcomes any bon•a'flde '~ scientist who wants to visit his laboratory to see what he is do{ng and ~ !~~=°how he ta doing It. He says he has nothing to• ide. ;~s~~ L~.r .1 i'tie f f f~ 'k.~ `°~' ti, ~ C b 11

iy . ~~t ~. _. _ ._.~_.. . • . . . .. _ . -~~ $) Judging from my reading of a copy of the talk gtven to the American C Soclet and f'rom what i eaw at the V A Hos ltal !n Eaet ' ancer y . . p .. =z, Orange, N:w Jersey, I would say that the experiment ls a crude one ~: ~--~ but effective tn that carcinoma in dogs has been produced. I am not :..:._. • ert enough to distinguish between these early carctzsnrnata puI- ex , p monary adenomatosi$, carcinoma in situ, etc. Thls I leave to the ~.•- expert pathologists. Nar.urally the exposure could be refined so that s were [attca of the emoke the do ettin could be anal zed cte h g g g y r axa c Also modlflcatlons of the ,mokin tech u could b l ll l h g n q e ca e y. c em made that would more closely reproduce the human exposure. But uibble The crux of th sltuatton !s wheth a th l l t q . e er s y ere s on general agreement by qualified pathologists that carcinoma, squamous- ••.-. cell carcinoma has indeed been produced. And even lf the cancer- production is lnvalidated the obvious.emphysema produced cannot be denied. • ^ ..f . :4 9) A copy of the paper describing the apparatus used to expose the dogs to smoke from a cigaret Is attached. C• R 1 I N ...r+ / 1d' Eue 6!