Tobacco Documents Online

-tROK: TfM OAJNCIL FOR T08ACCO RTSFABCH - U.S.A., 633 Third Areane, 2tew York, New York.1001T Conta ct : N. T. Hoyt OXford 7-9790 FOR RELEASE hT 6:30 ?.M. FDNDIIY. TMP!lARY 3. 1969 Thn scientist who has been assocLated with more research in tobacco aad health trin any other persor• declared today that "there is rto demorstrtit.ed causal relationship betveen snoking and asLyr disease. "Tte gwps in la:ovledge are so great that those who dogoatica.lLy assert othertiise - whether they state that there is or is not such a causal relationship - are preaature in 5udgxent. If anything, the pure biological evidence is pointing away not toward, the causal hypoth- esis." The statement vas stide by Dr. Clarence Cook Little, Scientific Director of T.ze Council for Tobacco Research - U.S.A. on the 15th anni- versary of it:g founding by tobacco grovers, varehousemen and aanufacturers. Dr. Little said that scientific progress in the amak.ing and health field, supported in large part by the Council, has shown that -- "l. The genetic arkeup of the individual largely determines his susceptibility to cancer, cardiovascular disease or chronic respirs- tory diseue tihich may appear after exposure to various environaer.tal challenge.s. ~ "2. }t<ny factors other than snaking are significantly associated with cancer, cardiovascular diseue and chronic respiratory disease. "3. Statistical associations between ssoki.ot and lung cancer, based on study of those two factors aloae, are not proof of causal reli- tionship in the opinion of rost epidaaiol.ogists0 a,ore ... I .61 V' 1 s I 1 / 11 I 0 43 2 123

l"` -2- "L. ~%3or evaluations of health and smoking tave been based or. painting mouse skins vith artifically prepared smoke condensates. But the reL tive degrees of can_er-foraing respor.te observed in these exoeriments neither parallel nor coincide with statistical data on :^e associatio:: of tobacco sskir.g and ds seases in mar.. Inte.-preta:iorn of certain lung tissue changes follov:rg snok±ng as teing unique or 'precar.cerous' is in dispute saong pa:ho:o- gats , "~. Rapid progress is being made in the developoent of i--przved methods for experimental ex:osure of animals to whole smoke for the sake of better control and more accurate evaluation." Beginning ten years before the issuance of the Report on Smoking and Health of the Adviso.-y Cosrittee to the Surgeon General, The Council for Tobacco Research - U.S.A., according to Dr. Little, "has spor.sored an increasingly effective program in tobacco and health research. "Tze whole field of smoking and health requires a great deal more researc:i and information before a proper evaluation can be mede," Dr. Little s,iid. "The Council's supporters have pledged continued expan- sion of our .i.ndepeadant research support as opportunities arise. "T.ii3 provides the best prospect yet that needed new lclwledge about tobaccii use and health will be obtained." J Dr Little is a aember of the National Acadesqy of Sciences, a former nanag:.ng director for sixteen years of the American Society for the Control ot Cancer (now the American Cancer Society), a past president of the Amerit:an Association for Cancer Research, and founder and fo rmer director of the Jackson Laboratory for Cancer Research. !°' i_1:=:1 i i_I {a i i C"~R M~~ 04,,~,~ 14,

eonard ajl71 •uftlc RcviIoPIs cwhsc: andAssociates,lne . c. eo: 527 • u uncoin Rowo • Ga(Pt NtcK. Nr 11021 • llt21 e9suy TOR: TtE COUNCIL FOR 70BACC0 RESFJIRCH - U.S.A. FOR RELrASE IN AH'S Di' is'PDXESDA7. AUG'JST 13. 1969 M TOBACCO-HEALT.'. P=S=A.?C4 GRU:TS TOTAL S2-HILLIC!; I New Tork - New research grants and renewals of previously awarded projects, both totaling nearly 42,000,000, were awarded in the past year by The Council for Tobacco Research - U.S.A., it was announced today. Executive Directo: W.T. Hoyt said 23 new Erants and 41 renewals were approved by the Scientific Advlsory Board, a group of 10 physicians and scientists whieh directs The Council's research program into tobacco use and health. T?le Council does no research itse?:; grants are made to independent scientists in aedical schools, hospitals, ard research institutions. N.r. Hoyt also anncunced The Council has airropriated $56,000 for its ar_zua: fellowship prograo wh:ch provides support for laboratory research by medical •students during su=er or other off-terr periods. This progra: has been under way for 15 years. Among the new gra:.ts are these: ..An epideaiological research prograW on huma.n cancer. (Part of a National Czneer Institute-supported program of field and laboratory research on cLr.cc:.; ..Smoking and the puL4onary blood vesscls. ..C'_garette asokSng patterns over tise: profiles of for=er sWokers co::are: J with continuing smokers and nons:nkers. ..Tunor formation and the antiviral acti:.rn of interferon. Since The Council was formed in 1951. by leading cigarette eompar.ies and organizations of tobacco Ero+rc rs and warehouse:en, the Scientific Advisory B:ard has avarded nearly 4CL original grants and s:uty more renewals to over 235 sc:- eatists for a total of more than Z11.,0C+0,000. (Attached is a list of scientists who received the new grants froa The Ccunc:= in the last year. Also listed are their institutions and project titles.) -O- r_ _ CTR f f N 0"°f' 3'"".k 5t

Recipients of new re3.areh grants, their institutions, and the t:tles of their research projects: aY'.AR J. BALCHU}I, Ph.D., Hastings Professor of Medicine, University of Souther Californis }ledie:i: Center, 1200 North State Street, Los Angeles, Cal. 90033• "Determinants of the course of emp2~seaa-broneh:tis! SANUEL MLi..z"f, M.D., Director, Division of Casdiolop, PhiLdelphia Cenera2 Hospital, 34th Street and Civic Center Boulevard, Philadelphia, Pa. 19104. "me effect of nic:otine on various para.;.eters ot cardiovascular function." JOFi?t A. BEV„N, M.D., Professor of Pharxacology, University of California, L05 Hilgard Avenue, Los Angeles, Cal. 90021.. "FacL.itation of vasoconstr:ction by nicotine and related agents." RA-''HJh'D R. BRC<WN, Ph.D., Professor of Clinical 0n:olop, University of Klscon- sin Medical School., 1300 University Averrle, Madison, Wisc. 53706. "Effects of smoking on tryF-tophan netaboliss in asn.• WI'=L',.K ALVIN CAR1'LR, M.D., Assistant Professor of Medicine and Y.icrobiologT, the Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltinore, Kd. 21205. "Oncogertr.and the ar.ti.Lal action of interferon." Bti"....RTRt?S EICt'W'L, D.D.°., Director, Science Resources Foundation, 57 Bay State Road, Casbridge, Mass. 02.138. 'Xetabol.ic and cytophysiolo6ical-cheaical interrelationships between toAacco smoke and the hunan aouth." M..'4ff J. ESBEi, Ph.D., Research L=wunologist, ?lason Research Institute, 21 Harvard Street, Worcester, Yass. 01608. "Studies on iasuinosuppression ef- fects of whole smoke and gas vapor phase inhalation." }{'J3RA! B. GA.bh'ER, X.:)., Associate Professor of Pathology, University of South- ern Califo:nia,2025 Zonal Avenue, Los Angeles, Cal. 90033. "An epideaio-- l.ogicsl research prograa on the etiolosy of husan cancer. Part of aovern- seat-sponsored (NCC) eomprehensiYe field and laboratory researeh program on the etiology and epidesaiology of human cancer." J0w°H B. CU!_°_'?.I, Pt.D., Director, Pulsor.ary Aerobiologieal Lborator7, Department of xedi-:ine, Saint Vincent Hosp'_tal, 25 Winthrop Street, Worcester, Mass. 01604. "?he effect of cigarette smoke on the ia.^nu:olo- gical and aetabol.it: functibn of alveolar sacrophages." Sri3=. L. KaUFt}t.LN, 2S.D., Associate Professor of Patholo®, Downstate redi- cil Cer.ter, State University of Hew York, 450 Clarkson Avenue, Brooklyn, N.Y. 11203. "Carciriogen-induced alterations L1 the cell eyc:e of the '!}p! 2 alveolar epitheliil eeLl." Ihi.S MANDL, Ph.D., Prcfessor of Biochemistry, College of Physicians usi Sur- geons, Columbia University, 630 West 168th Street, New Iork, N.I. 10032. "Elastolytic breakdown in the etiologT of FaLzonary emphysema." RICFJ.RD L. NAF7E, M.D., Professor and Chsiraan, Department of Pathology, Penn- sylvania State University College of Medicine, Hershey, Pa. 17033. "Smoki..ig and the pulmonarJ tlood' vessels: a quantitative, sorphologie study." J ~~~R N~~~ ~~~,~ ~ ~

(1) AI3~MT H. NIDEN, K.D., Professor of )tedieine and Direetor, Ptilioonas,- Disease Section, Department of !{edicine, Te¢ple University School of Hediclne, Pt12a- delphia, Pa. 19140. 'Effects of cigarette sanks, drugs and noxious fuaes on the terainal airways with special reference to the terainal bronchioles.' 5h'ELDOtd C. SCl40'AS, K.D., Director of hboratories, Tle Lenox Rill Hospital, 100 East 77th Street, New 7ork, N.Y. 10021 . •}lost Saotors in huaaa lungs re- l..-ted to lung carcinoaa." 1RILIIUI REG:*_SCN, M.D., ?rofessor and Chairman, Department of Nedical Oncolog+, ?ledieal College of Yirginia, 1200 East Broad Street, Riehaond, Va. 23219. •BES function, tumor induction and arowth.• UIRICH H. SCHAEPPI, H.D., Mason Research Institute, 25 Harrard Street, worces- ter, Hass. 01608. "Changes in EZ and behavior induced with the protracted intravenous adainistration of a3al1 doses of nicotine in unrestrained doEs." LUCIO SE7F1iI, M.D., Division of Cancer Research, University of Perugia, P.O. Box 327, Perugia, Italy. "Blood-borne carcinogens in souse lung tuaorigenesis." SNC.'I SHIBATA, Y..D., Ph.3., Associate Professor of Pharsueologr, University of Hawaii School of Medicine, 3675 Kilauea Avenue, Honolulu, Hawaii. !Study of sensitivity of rascular tissue to nicotine.° LUCILT S.".ITH, Ph.D., Pro'essor of Biocheaistry, Dartmouth Hedical School, Hanc- .er, N.H. 03755. "The inhibition of e7tochroae e oxidase b7 tobacco coke." LUUIS A. SOLOFF, M.D., Professor of Medicine, Chief, Division of Card.iology, Tezple University Health Sciences Center, 3400 North Broad Street, Philadel- phia, Pa, 19140. "Specific effects of saoking on aqocardial auchanics, sao- casdial sutabolisa and on enzTses and forsed elements of the blood." DA7ID H. SPAIN, M.D., Di:-sctor, Department of Pathology, The Brookdale Hospital Center, Linden Bouls.ard at Brookdale Plaza, Brooklyn, N.Y. 11212, "PuL-onary parencWma'_ alteratiois in an autopsied 'nor_•al' population as related to age, sex and environmantal factors." CA.30:..INE BEDELL TROY.A5, 1S.D., Associate Professor of Medicine, The Johns F?op'rci.^s University, 725 North Wolfe Street, Baltimorti, ?1d. 21205. 'Cigarette s:okir.a patterns over tine: p:-ofil es of fo:=-.•r aaokera eoeparev' with continuing ssokers and nonsaoYera." JCILN V. kTILL, M.D., Ass:.stant Professor of Medicine, Uni.ersity of Colorado Medical Center, 4200 ]:ast Hinth Avenue, DenTer, Colo. 80220. "Effects of ciga.rette emoking and of chronic aizway obstruction on hypozic ventilatory drive in san." -Q ..~-r..: -.; J t.,•' TR NN 043217 t