Council for Tobacco Research
Cigarette Smoke-Induced Cancer of the Larynx in Hamsters (Cinch): A Method to Assay the Carcinogenicity of Cigarette Smoke Progress in Experimental Tumor Research, Vol. 24 [St Hamster Experiments Are Valid Assay of Tobacco Smoke Carcinogenesis]
Fields
- Master ID
- Ctrmn00041967-2810
Related Documents:- CTRMN041967-2114 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042115-2200 Deposition of Freddy Homburger, M.D. [Deposition of Homburger in the Matter of Broin]
- CTRMN042201-2213 Chronology of Events [Letters and Chronology Outline Dispute Over Publishing Research on Cigarette Smoke and Hamsters]
- CTRMN042214-2228 Inhalation Carcinogenesis Experimental Investigations on the Effect of Cigarette Smoke Inhalation on Small Laboratory Animals [St Effects of Long-Term Exposure to Tobacco Smoke on Small Animals]
- CTRMN042229-2248 [Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042249-2251 [Comments and Suggestions on Study Titled Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters]
- CTRMN042252-2269 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53 [St Cigarette Smoke Caused More Cancer in One Strain of Hamsters Than Another]
- CTRMN042270-2294 Progress Report for the Current Contract Period and Renewal Application (with Budget) of the Project Entitled the Determination of the Usefulness of the Golden Syrian Hamster As Model Animal for Inhalation Studies [Cigarette Smoke Inhalation Caused Macrophages in Some Hamsters' Lungs and Reduced Weight Gain But Did Not Affect Mortality]
- CTRMN042295-2298 [Summary of Meeting on Status of Research]
- CTRMN042299-2304 [Draft of Contract for Inhalation Studies in Syrian Hamsters]
- CTRMN042305-2308 [Comments From Counsel About Contract Form]
- CTRMN042309-2316 [Agreements Between Ctr and Bioresearch Institute and Bioresearch Consultants]
- CTRMN042317-2345 Skin Painting Studies in Syrian Hamsters Skin Painting Techniques and in Vivo Carcinogenesis Bioassays Progress in Experimental Tumor Research, Vol. 26 [St Skin Painting Caused Tumors in Hamsters More Frequently Than in Mice]
- CTRMN042346-2350 Pulmonary Eistopathology of Hamsters Exposed to Smoke [Histopathological Findings of Study of Hamsters Exposed to Cigarette Smoke]
- CTRMN042351-2403 [Expanded Study of Mouse Skin Exposure to Whole Fresh Smoke Condensate Compared to Skin Painting Final Report]
- CTRMN042404-2405 [Ctr Delaying Approval for Continuation of Smoke Inhalation Studies Seeks Guidance in Procuring Funding]
- CTRMN042406-2406 Bio Research Consultants, Inc. Consultants to the Tobacco Industry Since 1959, Is Now Offering A New Technology-- A Fresh Smoke Inhalation Method [Offering Smoke Inhalation Studies to Tobacco Industry]
- CTRMN042407-2422 [Results and Methods of Bioresearch Consultants' Studies Are Property of Ctr Inhalation Studies with Cigarette Smoke]
- CTRMN042423-2423 [Disputes Claim That His Actions Are Breach of Contract]
- CTRMN042424-2424 [Suggests Meeting with Hockett and Jacob Before Presenting Paper]
- CTRMN042425-2425 [Summarizes Conversation Publish Scientific Data But Clarify Source of Interpretations and Ownership of Patents]
- CTRMN042426-2426 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042427-2427 [Abandon Bulletin on Inhalation Studies with Cigarette Smoke Delay Involving American Society for Testing Materials One Year]
- CTRMN042428-2473 [Manuscript on Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Submitted for Approval to Publish]
- CTRMN042474-2552 "Final Report on Contract C-191 A Project Entitled "the Determination of the Usefulness of the Syrian Golden Hamster As Model Animal for Inhalation Studies"" [75 Weeks' Exposure to Cigarette Smoke Produced Various Results in Hamsters, Including Macrophages in the Lungs, Increased Heart and Lung Weights, and Decrease in Body Weight]
- CTRMN042553-2553 [Encloses Assignment for Patent No. 3528435 Seeks Direction in Withdrawing Paper at Federation Meeting]
- CTRMN042554-2554 Sugar in Tobacco [Deplores Speculation in Tobacco Controversy Reports on Successful Studies of Smoke Inhalation with Hamsters]
- CTRMN042555A-2555 Fluoride Ion Excretion After Inhalation of Several Fluoroethylene Derivatives [St Exposing Rats to Atmospheres of Fluorinated Ethylene Compounds Increased Urinary Excretion of Fluoride Ions]
- CTRMN042555B-2555 Pulmonary Histopathology of Hamsters Exposed to Smoke [St Exposing Hamsters to Cigarette Smoke Resulted in Effects on Pulmonary System]
- CTRMN042555C-2555 Response of Rats to Pyrolysis Products of Fluorinated Polymers [St Physiological Responses of Rats to Pyrolysis Products Included Diuresis]
- CTRMN042556A-2556 Tumor-Associated Alkyldialacylglycerols (Adag) and Other Lipids in the Thymus During Irradiation-Induced Leukemogenesis Pathology 2202 [St Analysis of Tumor-Associated and Other Lipids in Mice Following Radiation Doses]
- CTRMN042556B-2556 the Endocrine Role of Dietary Lipids in Mammary Tumor Formation Pathology 2203 [St Mice Fed Lipids to Determine Effect on Tumor Development]
- CTRMN042556C-2556 Effects of Altered Dietary Fat Intake on Serum Prolactin Titer Pathology 2204 [St High Fat Diet in Rats Resulted in Increased Serum Prolactin Levels]
- CTRMN042556D-2556 Altered Incorporation of 3h-Thymidine in Hamster Tracheal Epithelium Caused by Respiratory Carcinogens Pathology 2205 [St Hamster Research Suggests That Dna Damaged by Respiratory Carcinogens in Vitro Can Be Repaired]
- CTRMN042556E-2556 Histopathology of Respiratory System of Bio 15.16 Hamsters Chronically Exposed to Cigarette Smoke [St Hamsters Exposed to Smoke Had More Pathological Lesions in Their Larynxes]
- CTRMN042556F-2556 Peritoneal Mesothelioma Pathology 2207 [St Study of Patients with Symptoms of Peritoneal Mesothelioma]
- CTRMN042557-2573 Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53, No. 4 [St Smoke Exposure Resulted in Reduced Body Weight, Enlarged Heart and Lungs, Hyperplastic or Neoplastic Changes in the Larynx, and Microinvasive Cancer in Hamsters]
- CTRMN042574-2591 Experimental Lung Cancer Carcinogenesis and Bioassays Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters [St Smoke Inhalation Produced Hyperplastic Changes in Hamster Larynxes and Decreased Body Weight, But Did Not Affect Mortality Strain Differences Were Pronounced]
- CTRMN042592-2599 ""Smokers' Larynx" and Carcinoma of the Larynx in Syrian Hamsters Exposed to Cigarette Smoke" [St Smoke Exposure Resulted in Cancer of the Larynx and Severe Epithelial Changes in Hamsters]
- CTRMN042600-2603 Homotransplantation of Larynxes of Cigarette Smoke-Exposed Syrian Hamsters (38760) Proceedings of the Society for Experimental Biology and Medicine, Vol. 149 [St Sections of Hamster Larynxes Were Transplanted Into Cheek Pouches of Other Hamsters Hyperplasia Caused by Cigarette Smoke Persisted Up to One Year Without Further Exposure to Smoke]
- CTRMN042604-2626 Differentiations in Cigarettes Off Materials Other Than Tobacco Medicine Et Hygiene, No. 1216 [St Smoke From Cigarettes Made From Cytrel Contains Less Tar Than Tobacco Smoke and No Nicotine]
- CTRMN042627-2670 Advances in Modern Toxicology New Concepts in Safety Evaluation [St Syrian Hamsters Are A Valuable Option for Animal Experiments]
- CTRMN042671A-2673 Detection of Chemical Mutagens Using Concentration Gradient Plates: Observations on Results with 414 Compounds Toxicology and Applied Pharmacology, Vol. 45 [St Discovery of Chemical Mutagens]
- CTRMN042671B-2673 Dominant Lethal Studies in Rats of Five Hair Die Components: 2 Nitro P Phenylenediamine, 4 Nitro O Phenylenediamine, M Phenylenediamine, 2.4 Diaminoanisoic Sulfate, and 2.5 Diaminoanisoic Sulfate Toxicology and Applied Pharmacology, No. 45 [St Weak Lethality Results From Exposure of Rats to Hair Die Components]
- CTRMN042671C-2673 Motor Oil Antagonism of the Effects of So2 on Pulmonary Function in the Guinea Pig Toxicology and Applied Pharmacology No. 45 [St Motor Oils Reduced Irritancy of So2]
- CTRMN042671D-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. I: Methods and Dosimetry Toxicology and Applied Pharmacology Vol. 45 [St Hamsters Exposed to Tobacco and Cytrel Cigarette Smoke and Results Noted]
- CTRMN042671E-2673 Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters. II: Histopathological Lesions in the Respiratory Tract Toxicology and Applied Pharmacology, Vol. 45 [St Tobacco Smoke Resulted in Larynx Problems Including Invasive Carcinoma Cytrel Smoke Resulted in Much Less Damage]
- CTRMN042671F-2673 Pulmonary Pathology in Rats Exposed to Marijuana Smoke for One Year Toxicology and Applied Pharmacology, Vol. 45 [St Rats Exposed to Marijuana Smoke Developed Focal Pneumonitis in Proportion to Dosage]
- CTRMN042671G-2673 Studies on the Pulmonary Uptake of Paraquat Toxicology and Applied Pharmacology, Vol. 45 [St Distribution of Paraquat in Rat Lungs Was Not Uniform]
- CTRMN042674-2749 Chemical Carcinogenesis in Syrian Hamsters: A Review (Through 1976) Progress in Experimental Tumor Research, Vol. 23 [St Hamsters Are Useful Experimental Animals for A Variety of Carcinogenesis Studies]
- CTRMN042750-2764 Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters Journal of the National Cancer Institute, Vol. 65, No. 3 [St Cancer Was Developed in Hamsters Exposed to Tobacco Smoke Cancer Rates Were Proportional to Smoke Concentration and Tobacco/Cytrel Ratio in Cigarettes]
- CTRMN042770-2772 in Vivo Carcinogenesis Testing Toxicologic Pathology, Vol. 7, No. 1 [St Smoke-Inhalation Experiments with Hamsters Are Quantitative Assay Method for Relative Carcinogenicity of Cigarette Smokes]
- CTRMN042773-2782 Carcinogenesis in the Upper Aerodigestive Tract [St Carcinogens Such As Tobacco Applied to Mucous Membranes Result in Multiple Tumors Which Are Difficult to Treat]
- CTRMN042783-2787 Subchronic Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters That Develop Laryngeal Carcinoma Upon Chronic Exposure Journal of the National Cancer Institute, Vol 71, No. 3 [St Smoke From All-Tobacco Cigarettes Caused More Respiratory and Larynx Problems Than From Cellulose-Derived Tobacco Supplement Cigarettes]
- CTRMN042788-2796 A New First-Generation Hybrid Syrian Hamster, Bio F1d Alexander for in Vivo Carcinogenesis Bioassay, As A Third Species or to Replace the Mouse Surv. Synth. Path. Res., Vol. 7 [St This Strain of Hamster Is Perhaps the Best Suited for Cancer Experiments]
- CTRMN042797-2800 [Comments on Slides From Effects of Smoke on Upper Respiratory Tract]
- CTRMN042801-2802 [Conditions for Approval of Publishing Findings]
- CTRMN042803-2810 [Disputing Ctr's Decision to Discontinue Research Chronology of Research-Related Events]
- Author
- Progress, I.N. Experimental Tumor Research
- Branfeld, P., Bioresearch Inst
- Homburger, F., Bioresearch Inst
- Russfield, A.B., Bioresearch Inst
- Branfeld, P., Bioresearch Inst
- Depository Date
- 08 Sep 1997
- Box
- 267
- Type
- SCIENTIFIC ARTICLE
- UCSF Legacy ID
- lot30a00
Document Images
/1
Snw,l.InJ,k.d ( -in,vr ul th. Ljr)na ,n ll.inhlcr.
a
317
1 ~F,ua~ 1. ( S, 9 ~nJ I I dlwtr~re the Ahropn~~,a ul ~.n,:r of tne lar)na in
a,h,.r~~M~ inhreJ Mnbt.n c.poaN to C,wrttte smole.
f,; 7 Hjmstcr: Pap1/lomu o(voeat eord iii,tA lrjJ,: 3 Ayperplasy in a S)nan Aamster
carkM'J W snNK; fron, I R I K.m,.cly refcrencc cipr.ua.
l',c. y H,mun: S~n. tyfw of ks+on (as in fiy. 71 in a larync aufK) frum a Aeavy
anMllcr
l,c V H~nhi:r. 1)dGran,ura~! aa,umoua crll :ar.munu uf I,r)na m S)run fnmstrr
ctpuarJ W amul: )n,m k,ea,l) I It I
I rr ItJ Nnun: Thas,,nr t)K of ksron (as in fir. 9) in o larynt b,opsy from a
f+av.) .nrH;r.
I~r Il. Ildnbhr. UnJdTrr.ntutrJ tyudn,ouS eell areinonu of larynt in a funutcr
eaf+u.rJ ta smula frun, I R 1 A.n,u.ly rcfarnn:c ogOr.rtOf.
I ,C. l:. Il,mtm TIk, aenh' I)I\' ,d I:.wn (a% in lig; . 11) ,n i I,rr)nt hwM) hum .6
llca,) ank,laf.
CTR I I N 042 . ?G7
I
I
I
i
I
i
I
I
/ 1
1'roc ean Tumor Rcs , vot 24. nr+ 3ISl1v rKiraer, B4ut Ivw/
Cigarette Smoke-Induced Cancer of the Larynx in
Hamsters (CINCH): A Method to Assay the
Carcinogenicity of Cigarette Smoke
P. Bra.rrt,n, F. HnMnuRC[n and A.B. Ruscrut.n
tlwkouar,h In.tnuie, Cimhndt;e. Mua.
lrNhwluc li"nr
e
Atiemr+ts to induce in e.t+erimental animals cancer of the respiratory
tract hy inhalation nfriFarette smoke with statistically significant results were
unwrcc..ful until f)uvi tiwu i r~I ol (Ir)71) employed the Syrian hamster
.InJ uhtaineJ %~jih t;crrnan rcferen:e ci`;rreues smoked in a Hamburg II
machine carcinomas of the laryna in l0/, of the animals. Investigators at the
tlioRcsearch Inbmutc demonctrated that certain inbred strains of Syrian
harn,ters IdIO 15.161 were more resistant to nicotine liven intraperltoneally,
and also to smnke rnhalauan, than rats or mice or randombred hamsters.
This. toEether with the fart that they were more sus:epuble to sarcoma
inductiun by sub~utaneuus In/ectron of polycyclic hydrocarbons, prompted
ntir u.c tif I11C) 13. 16 malc hamaen in a IarEc.calt inhalation study, eaposin8
thcm tu the bmoke of I R I Kentucky referenre cigarettes smoked in a modlfied
WaltonMurrissey reverse smoker (Hurrr.ISNN and Wrl»mIt. 1970). This
resulted in 19.6'.% of laryngeal carcinoma in the e+posed animals. In BIO
87._0 hamsters .imil.lrly treated at the same time, only It: of the animals at
risk Je.eloped larynx cancer (Brtt.it.t.u tr al., 1974). This pointed out the
importanre of genetic factors as modi6ers of tobacco smoke amnoEentsis
and the necessity to use only appropriately susceptlbk inbred an,mals and
simuhantoui, 'referrnce' ciparettes (capable of carcrno8enesm in esperiments
to meisure Larrinokenic potency (Ho%tHutttt It t/ ol, in pre.+j
In a later study with British lihered refertnce cigarettes the csposure time
and frcyucni;v a. wcll as the cmuke ronrentrition and duration of e.rtosure
wcre m.rtaaeJ NiIh ihc rcsuh that ?7. ui the anim:,ta thuw e%posed to smoke
CTR MN ~°..342-r GE5
®
Ihrattt.ti Ilwnt.r~r Nt.~autu
11h
F:Sum 1. ), 3, t, 1.nd 11 dlustrau It.e hlsto6cnesu of ancer or Ihe raryne in
eusccptIWe inbred hamuen e.poud to cigjreu. smoke.
f,ir. 1. Harnster Normal resp,ratory epuhelium in a rham.emoked rnimal.
fit 2. Hururt Sa.w tyte o1 uuuc (as in 6y. 1) in bopiy of laryna of n petient.
At. J. Hanate, Hyv Y,+lab~3 grad. : ath mild hyperkerataa in Ihe epltnel,um of
the laryn. ol an an,m.. etposed tn I lt I Kentucky reference caprette emoke.
Ay. 4. Hunun Ths ume type of kss+on (es tn 66. )) tn a luylu eiopsy from. heavy
snwk. r.
for. J. Hamster Hyprryl4w 3) end eevcrt hypcrkemosis in the larynCal
epithelwm of an anonvl erpo.cd to I R 1 Kemucky reference upreue smoke.
f,p. 6 Hunun The umc type of I tion (a in f.6 3) in a laryne biopsy from a hu-y
emok, r.
tI
y
f
L,r' ei >i"4 )) i 7 04,22766
SnrrlrIndisYJ Caiw'cr ut thc Larynib in I Irntsten
319
Bo .m nlu. P. and Hrrrrvr, .it,. F.: CiNnoue snwlie inhalauon studies in inbred Syrian
hamti.rs I. MahuJb anJ Jotinklry Ahsu. 136, prOSram of 17th annual mc.bnp.
Sralcl> uf To.aadrbpt. S.,n Frirwn:u 1979.1% 117.
I),r--Ti %%%aL, N'.: Cru. an.. MJ ; H..ct. HI' : L.ntoot. U.; RttAtrn, G.G and
St'n%r Wr.. 8: In.esu/anonf on Ihe tIl'etits of ehronic cqpreueemof,t rnNilaUon in
Syrian golden hamsiert J. nain. Cane.r Inst J/ I711.1131 (1973)
Murt.u.., D and Winot.. E.L.: Chamber de.elopment and aerosol dispers,on; in
HA..,. Nirrttmi.r and Gnrrar InhaL+uon earc+nollenesis AEC Symposium
S.ritS It, CONF6V1001, NalionMl TeChni.al Informalton Strrice, 1970. pl+. 173-119
H-.um .,,t.. F.. Pu, K.J.. Sabt,,. E.. and 1li..nw. P.: Crwrcue tnake rnhauuon
tuuJaa in onMeJ S)rian hamarn. 11. Mitlo(+alhological ksions in the respiratory
trio Anstr 137, Pro`ram of 171h onn..jl mrcnn5. Sa>twy of TOaaolod>, San
Fran,as.~o IV7r. n 137 011
Hu.rn r4ar, F; Simu. H, AttImrr, J; D.avtt%. P.. and MuTt. P- Carcnnneu uf the
Ijr)ne in hanmtrcr, eap.nrJ te ciNntte smole Am J. Pilh Un prnfl
ur P Mi ..n tu. 8,o-kewvrch Irtslaulg, 9 Comm.rcu/ Are., Camnndvr. A/A 0111/(IJSA)
CTR I'AIN 0402-769-
k
Iirr%rrru'Hiwrt.a..rr.Kta%i nw 319
JevelopeJ cancer of the larynx IBI.RNFCLI) and HUMNURCiCR. 1978; HoM
xuRCLR er al.. 1978).
At lower smoke concentrations but with similar exposure parameters.
a smaller percenta8e of the animals developed larynx cancer in proportion
to the dose of smoke to which they were exposed. When exposed to smoke
from cigarettes made ofthe tobaccosubstitute (Cytrel' )t, none of the animals
developed cancer. When hamsters were exposed to smoke from cigarettes
containing 50. 80 and 100ie tobacco. the incidence of larynx cancer caused
by the smoke was proporttonate to the amounts or tobacco in the cigarette.
Dettrrption oJ PoJte.
The poster shown at this symposium illustrated some or these obser.a
tions and further demunstrated the histogenesis of the type or lary~gra
cancer whtch, in susceptrble hamsurs, is caused by cigarette smoke It also
showed that the dtsease induced in these experimental an,mals is htstolog,
cally tJcnural to human IarynBeal cancer (liy. 1-1?1.
Cort(lutirurt
An experimental method is now available for comparative studies or
cigarettes and as a guide toward less hazardous smoking materials.
Smoke inhalation in susceptible inbred Syrian hamsters results in car-
cinoma of the Iaryn:, which is histologically identical to human laryngeal
carcinoma. which eptdemtuloEtcally has been pro.en to be associated -itn
smoking.
Slatisttcally highly si8niticant cancer incidences and their direct relation
to the dose or tobacco smoke inhaled quald) thts procedure as a valid bio
assay of tobacco smoke carcinuFenesis.
ReJsrtnc tj
atacnt,o. P.; HoreLacre. F. and Rt;sarnLat. A!. Strsrn diRertnees in the response of
rnbreJ Syrun Awmstcrs w.jNrUtc snmoke rnlu4uon. J. natn. Cencer Intr JI
1141-1137(1974)
' C)uc/ is a rcliitcr.J triJrniart, ut th. Ccljnhe Corpur.tion
L..M j R 1 1 I 7 0' 2'/ 6LJ
2
.
i
1
t
E
