Council for Tobacco Research
Cigarette Smoke Inhalation Studies in Inbred Syrian Golden Hamsters Journal of the National Cancer Institute, Vol. 65, No. 3 [St Cancer Was Developed in Hamsters Exposed to Tobacco Smoke Cancer Rates Were Proportional to Smoke Concentration and Tobacco/Cytrel Ratio in Cigarettes]
Abstract
ILL
Fields
- Master ID
- Ctrmn00041967-2810
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- Author
- Jnci
- Bernfeld, P.
- Homburger, F.
- Pal, K.J.
- Soto, E.
- Bernfeld, P.
- Depository Date
- 08 Sep 1997
- Box
- 267
- Type
- SCIENTIFIC ARTICLE
- UCSF Legacy ID
- kot30a00
Document Images
Cigarette Smoke Inhalation Studies In Inbred Hamstern E
TABLE 7.-Srnoke deposition shailr. in ha+n+ICre rnhaLnq rmoka /rnm thee lqpn u,/ n;arrteea at hto
co±r e:'.+ . .r
Marker' or c{rarette :ar' deposl:ed in t!e resp:raxry :ra:: af c ..s
/
Origin and dose level
of smoke
I:o of
hams:ers
stud;ed
..R tar
Smoke concen vg marker ur tar srte re:at:,e .-r'a.e
tratlon in expo- arta
sure chamber.
mg tar ml
IOU'4 tobacco cl{tarettes:
High dose of smolke' 12 210
Low dose of smoke' 6 10 6
50% tobacco cigarettes:'
}i:gh dose of smoke' 12 14 2
Low dose of smoke' 6 7 1
100't Cytrel ciRarettes:
High dose of srno;e' 1? 7 i
1Dw dose of srr.
DCBP per
DCBP per Tar per
Tar per Tar p.r
resl r3.
Tar in
Tar :r
lungs' lannx' lunKs' larynx' tory iunps ;ar>^.n
222 /0 7 7) 021 t02T1 160 15 173 0 1n 5!r1i0
U r: , 10 231 0 11 ti/ 111 63 7 9 68 V Q53 ''.i-'y
2 62 I 1 391 0 24 Ip 2=1 12" 12 13!i u !?" 41 .; ,1
143 (046, 0 1177 lq Uac, 69 3 6
4 79 r5J31 024 r03r1 lld 5"
t r jyt tt un.t I1I,li.j, ar) ?;
' N'ean va!::es
' Diring one 12-rr:.c etp^:ure Sf tet: ':r e\ er:re.. a! crnd.::o^; ' -rr.o'r.e eCpo:re
Qi BP. 2 rr'.g aar:t', (er :arCar,. ]: R
\ Ja'.:e
.`rr^- . .=?' .. . . . - . . . .._ ... . 'r': ~.t:-. . .
; :,rwna a:
' ~:nFs acd :ar.^\
1: .rd'..R ,. !a. .r ., . .. o!a:..e ..'ac.. aea :! e .r . ... ..
:moKe in e\i,,.:re ..
f}1P I nrrYl.i'1 tc it D( BP ;!",. .It:. 'n 111 'tlt
rC, !tl 111 tll,:raI\I,:r tr i, :11 ..
hl;,',! .,i tnt(1',..!;... .u:lrn.,i, . . ` L.t:r . I.: n! ....h
t~~trri.tl:~,rt t,-t:ll(;t: , `f ll;, ., tlh
I'! rntrr.:,,t, ..., .. t1 tn t,. a,r. rm rhr Irnr,lrnls
- ;. , .i:l' _t'1 :,,r
i :l'.ttr/l, 1 I..It . ') .I^t!
t
.r:t.tn, .t IJi rt,;,lt,
ir t J( Ir!1 ,:.u;t!. 1.0 lo rn, t
C., )n,rr,.ntl~. thr
:ntf:.~171~.ti ~.lillrs inr cJr ,rnl: Itrntl'.
1lt I' :.rttt!.1:.[ ,r~L I.tfl. .., t,t'tr rtr'1
,.. . . tr,r _.
,. ~..1 ~I: ~n I hlr -
t:, Irlc.ln r.ll,Ir - In.:lt.ttt th.rt /,rr rIth 111
:hr tt.u tln,r Ictt;, of smoke. unls rrlJnscls ,nt,tll
t!liftrrnrrs rvti:rd ')rtt,rtn thr 3 tspr, uf tlg.ucttr,
t,lth rttz,Irt1 tn tht Jrnounts Of tar (Icf)n,lttt! In Ihe
rr.I,Ir.ltr)r% s,trln I hrs nh,rr.Itlnn t,.I, truc t!r,;)ut'
Ihr I.t, t Ih.tt ,tbuut four ttrnrt It,c I.Ir t,,/, tJrIl,rrrtl In!u
thr m.un,trr,trn `rnt,kc bs onc ,111C.ttrel tlK.,rctte thJn
b, une all-toh:tcoo ctGJrrnc
rhr tfosrrr,pon,e rt!,luon,hlp in t,)r drpo,ttlnn ,.,ts
c,lll,f.,cturt f, ~r t.Ith ii tl:c :4 t\ilrs f tl:.lrrttt tr',Irl
.Int1 !, ,r c'Ith ttf .'Ir '_' Ilr, uf ,!t;l, 11rt ,lu:!I,tl
I hc nu.ln t.tluc, :.,i,!r 7 fr i.ir tlr;),,,I Irrn Irt thr
rttf,IrJtnr, Ir.lt I t ir.lrl~ t!:trlnn,tt.ltr,e tf:Jt .I;,I,rt't 1Ihi.
,J t IC-Irt rlr~ ,1`1"it. Il.r,! Il, t,t.t!.il,,! Iftt i.11IC,
Jn,! i.lt%nlt t`I ihl c\;u'Illltnl.l: rtitn In IhI
l.l,r i r~iQJrt:tr t,:.~, 1111119 (ttrr: ,!uth l.lu,r t",
!Jr,nta.,tl t:ucl:,rc., T`.,t. .It:lot:n!c , t.lr tit: ",Iltr.
s.t'rr in Qout' rtittltln,hifl tu Ihr rc;uttl,r t.lr tI illtrn.
rr.lllins In Ihr Inf;.l:.tt;, ,n , h.,,`:'.
. r.!,Itlt'n:, .,I 11Ii ),-11.
. \ti f.)r rfl" t.lr r: ... ' ...r:l'. . .
!.Irtn\. lnt! :hr t,!:"ir rr,;,lrI.,.., ...
\ te.r:Jln rt!Jr:I trlhlrl J'" r,. h-t,r ,.
:!Ir t\(nrltnCn:,ll :Inl:tl.f', .1 ! , 't.
..L.Ir('Itr 11r, µltlr Inl t^t :.~r r.ll,~i. ~ .._~.
( ..,rtr'tir.ll tuc:^t rn.t .tf ; ;q r ~rr ,. .
...r r:thcr Ins.l.ltr ')r . I.11 ttn~r.rl rr..
llliltlrn(e `1 '.Ir.r.t;r.,i ,-trclnc,tT:,l ,J, l"r'~ -. .. I, '
n t:t;.trr:lrs t"nt.t:rtlnq r,n!t ( . .
. .rlL:` .I':,! !.rr1n\ .1.'w. I'11',rt. .
t...lrrltt,
( ttrtl ,.,t the lutw tlucr Ictri lnc!.ttrd .,r,,
n.r:n.t in Irnlrn.ll bur t,Il,rc! !r, t,lr n
hInG, Int! IJnn\ th,lrt did ,nu,ke of tll;arrl', t r; .l n
nlt; nl% (%rrtl IIt thr hl¢h t!r r Ir~rl .`.,hlr!: I.r"
tlut ct! nu Lrrt II`t.tl t,Irt Inulct.ls
1117rr1 tftr IInUUnls of :.Ir tlrlJnc;;-t? t.rrr r\(frr~!
prr curfJcc Jrr;t . In ,rrbltrarv t:ntls of !t)ne, tr:d Lu%:l\
Itturtlln` to flnntcnt,lll tlf,. otcrt,hr! ;tlr:~i, 'IL:' ':
"ntrntr.luuns t,f I,tr t,'re fnunt! in t')r !.trrl\ c',..r'. .
!:c lun4, ,:r - tr n llr, ,:c. `.,t .. , .
~f Iht. './r ! t.lU±rt! In th` rr;,I: I.. I. ,
hr l, lt;iz.
DISCUSSION
fht Int1,1,'n:e u! i.tr.nerJ! ,.Iri: `-:.I f).,t,,' .,
Itk. ~I,Lli.l.t st.lVr ri in nr,v)'l; r,: , rl.l)t ~:,,:,ir ii
I\11 1,,: ,, \, 1 !1'!\'_ K
C1+ R I I I I 0 4 2- 7 6 0
e
888 Bern/eld, Homburger, Soto, and Pal
erere inh.lltni:~ toblcco smoke t.lc IO : tn the orielr:.:l
studies b\ Donten1.111 et al. r'1 and I I i'-. , IS Of l;7
antntlls of both sr%rv tn the tnOIC re(rnt ,otk I
Don,rnl.rll rt al. , ?;, ln :In IrtG/r-A :-,f h.lnl,l:,,
l.t h:lcc Ilrct l(lu,Is b(rn II11(' t(, ,lrrllr It In Int ll!, nt c'
Uf I!1°o nl IIr.nLrJl tar(In,nll1 ~inurt~inl.l.nc I.Inttr~
In srn(ll.ec\pusrd hjrn,tcn tl .\1tltfuatlun of Ihc
tondiuons of stnoke exposure in the same inbrcd cu.lrn
of hamsters ustd earllrr has nt,l. led to .)n Intrtltnrr of
Invasttie cancer of the Iamnx in ;Ilmost 3i o of the
:Iluln:lls e\po.rJ w tub.l(tn ,nlt,la. dc,lllu the f.lrt th.lt
(rltcruppcd uiz.lrcna.s l'crc u,cd .\t thr ,.Irnr ntnc thc
incidence of total cancers of the lann\. Inclueling e.Irls
carcinomas and circrnornas In evru. r,,,e rtl i7.1 0.
Such a strong recllonse has a twufuld :Idl.nlt.lL:e I t It
:/llot.5 7¢ot,d tllf(crrlltl.lut,n bctl.rrn the blttlnKl(
effec,s of smoke fr(Irn tlnt,us tc f)tc n( cl~.lre'ttrs. .Intl '_,
it Ir.lds ru .1 hlI.:h ,t.ltl,n(.II ,I(nl(It.lntr ( ncl t1111cr-
enctc be!..crn tltr~c t%;,r, .,i (IC.Irc'ttr I Ilr mrtfln(: -!.
(1v, ui u(;.Irrttc In~.i,t I:Ih.li.l;/l,n !t,ts thus br(,nr.r
n~Lil:c:.lba :11 Il~ .:IarIn1111.IJlrlf;
Iltlnunl.til
:II . . ~ ..,.i. . .... .. . ... .., . . .'1 .u.
(.Irllil~r:l~.t :t: t . '.tt ~II 411 !.:111!', !'
f( 'ri:.l lt , I:1 .I .. .
1.111i!: ~.. :I:.. .
t\IIl:ncn1 ' 1)'/r.i r....
~.~t.t~r ifl.ltt .~ .
('.t/t, .Ifl,: 1~,',t
,.(u.,(! L/:.r.: '.I
- i,.ll
: " :1 I, u ,
,II.,//tll,lr ulhrtll
.
...tI.I , . , : . r',. ) . . . .,.. . ., ,:.Ill,llt.rlll ., ':
t.i.'lir .:al,!Illl( l,lllt Iht,r
I!11- (lllitttrt,r .. i, ,I\nl!I
Ihr
llunl I ,!Ir
~~!,t,.l1'~I: ~ ~.11i. Int.ntlr (.Ittinl)tn.l, ,II!1. lllr
t!lifrrc n, ...(, 1;1 clrnlitt.lltt .11 thl I°~ It crl
>nltAc ir-In (\Irri .I;nnr. Ilt,l 11,U,! hl I)nlut I11.1!i ,r
.r! ' , ".r, 11"I (,II, :Il~,~t'll lt . .Illtl .I, li If,.lt t t / ,~ I
rtltL((ctf nl ttc.ltritri ht (.~tt! I!.t h;t,!`It .I,Iltul ,~f
I!: vn,A(. .I, ult.I.I:r 1 in !I: nl ,Iltn t"I Iu1It4t ,I
It ul~,nl.l, rn h.i:ll,ll l, ulll.liln` I1/:, ,lu~,.t ~b l lt.nt tl
l,rnPt,r UC. ttd:,'l l Ihrrr .tl.~~ 1~.1. .1 i:,.r~:r,tu,ntt Ltl:i,u!ul, liu Ihr
itl~tt, t~l II1/I', ,.tl(t ~ l:L.~:r. ..uh Iht I,II ~t;l
1~11 ut t.i:tlnUltl.l .tl(:Crtl,c ;t~::l ~ ...."~r t~,nttu:l.lIl~~n .(~,IlL:,~:li,
\tl l.lrlnla.l~ (.tr(Ir1 7 1.1. 1.1 t 11 ,at~'.! .Irl1 t1 1 l1 1 1
f\( I tllt ~'t \ t,MPIFM BkR I. -
I II\ : 4 .i. ititr :I1 !hr
Ilcrtcldc t,f ('\;u,curr arrr Llii(d \,1 .t.lu,l:, lli, :4:::;;
(,Inl J:fftrn.nLcc In (.Ittl:;'.:n.l .. l,t: ,..
h,t..((n c.ltl;tr ,n.! L(Itr ;,crl., .. , .:I'.'
., t..
h.lnl,lrts h.ltln(z dlr(I ,f,nnl.lnt-,r hltll:z
LIIIrJ
l.an nt c.ll t.u( In ,4rnrv, ,..n i)t ;.Ir l ilt In .
prornrncnt c(ftct n( tt¢.Irene cmoi.c InhIlInnn in tht
h,rmster I((ll.cccr. t,thcr 1)htnumcn.l Ih.ll t.lnn >t ht
rnctlookrJ resulttJ frnm ,mul.c c\luurc. 111 :,.Inuul.l:
thr G,rln.ltlnn /( t)trlln.lllcn.tnt :urnnl, I-!,II; ... t, .
rhe l.lr.n\ tn ul) lu U'o (,I Ih( .Inlnl.ll,. 111. "((Ilrrc ,
of ucrre hc(xr!)I.ICi.I uf th( I.Ircllvc.ll Ilnulz In ;Ip t
11N°o of Iht hIln,rrrc. Itltr((ct, In c(iu.llrlnc Int'
I1Lur:t nf the tru hcd. :In(I slltzht In( rr.l,,, tn ILr
frr(lurntc (,f pulnl.)n.ltc Ilc(,,LIr nl.lcr ,,, :.1,'
In 1nu,1 of Ih(',r InttIntt,. I ,.trl;
rt~lu~nr rrl.lll~tn,hl!1 1..1, ,!talt l! ,.1;~: .-
t'ntrnll.ltlnn IJ1 Iht'
I ,r t' ht'n
C.,nrI
I t, , n.urc rli.:.,! . nt{I!1 I,t r\;, ,..,:t
,I11!:, I ,, .,
, i i I\ j, . ,I ,...I It .., .I.. ,.; . 1'.
. I: . II .. . . . .. I~
' i I'.. ': '..II , . 'II
( % Itt! ( t!-:t:. :% .. .
If{!` (./ttlll4t'tll( .tiI .I.,i. . . . . .
pruh.lhll hc.r trrl rltn r.u,r(- ;,:- ,Il"I..,
I.) ,In"i.r 1.,-td Il.n(' !,t(,:l I,.I..'
1111, /tlilt' - f ,I11/K 1114 t:.Irt: '
I), II,.Itl.,n ..,.!,rc h.llr ,. ..
t:l:frr('n(c, In I,1i, tlll rf.;,~~lla
~.. I,~n. ,`tltl( tftCtl. 1!. .. ..I:.:.. n
,ht' It.Illt., ,I1 I: ~ I t .
,if __ . .Ir1.- At .. . ! tl , 1. ... t. ,
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CTR MN ~~~. F"G1
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a
Cigarette Smoke Inhalation Studies In Inbred Hamsters 887
containing 100% Cctrel than that from cigarettes
containing 100'", tobacco %:ould explain this (In(ilnq
This a~s(unpnon is borne out bt thc re,ults un thr
absence of an} idrelnogenic eff('cts of smoke from clga
rcttrs contaln!ng 100'° C,trel.
On the basis of marker studies. ben:een 91.6 and
95.9 0 of the cigarette tar retained bv the animals were
fuun(f In Itlc 1111114% In(i ntlll, ' flunl 5 In M°o \.('r(
depo,itcd in thc' lar\nr. \cscrth(Itss pr,lctically all
hlnlrtGic response nl.lni(t,rr(i it,clf ;n the IIr.nx of !hr
h,lln,l('r. fhlt nh,rr\,Illnn h('(nnn's 111I!I,II/I( tt'h(n Ih(
(nurrnnlls (Ilff(r(rl(t5 Ill sUrLl(( ,It(;1 h(Is,r(n Ihcsc la.n
orG.tns strrc t;lkrn into Ic(uunt. l'pun cxpresslnk,, Ihc
arrlounls uf (!q.lrcn( t,lr Jc'potil('(1 I>cr unn of .IIrLu(
,Irc:( uf Ihc,c n,u t.r fnuncl :h:lt !h(' conccntr.l!lon
of I:u (t,u ft(rrn 1;5fold to I."0i!fold hls;hcr ,It Ihe
5urLue (rf thr I,Ir,n\ !h.ln It the .Iltcul.lr surface of the
lun¢ This fin(i:ne It In r\(rllcn! ,t;tcrmrn! sslth
rrsulls tbt,int; h, I) f:I, s,cII as results
(lhrllnc(1 ht Blnn, :,rt ,I,t(rrs u!Ilrr 01.111 !hr h.rnl
stCr
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I11U,! 11t1likc'I%
REFERENCES
Q«(undrnen Or;anserand[rungen Z Itrrb,!-r. r+;' ~-
ly:'
4' N't!(a(R AP Ot")% RJ Bt tcN RH Incrrasrd 1:!r sr,n
,rras«d bnds ar+Qhl in (IQJrrne smok[<aposr:
9rch Ensnun IirJllh !11 lao-lii !Q:ri
RlRalfl n P 11, ,t/Nl R(,/R F( I,!Jrttr ,..r nh.l!.+n n..
in Inbrrd Nsnan hamsl[rs I\Irlh~dsnand dus,rnrus I,,.:,
Appl Pharmacol 45 ^87. 1978
+61 I1ntIRl R(./R F t'sr F:J. Srn F. [t alCrearrtt[ smnl[ nt_r:.,nun ,tndlrs rn rldnrd 1srl.(n
hrlnsrrts 11 Illuup.r!nd..~.~.,1
Irtwns In Ihr r«,ptrJrnrv nr(r 7+lucol lppl PhJrrnJ,r,l 4;
_, :P+ 197±
,'+ \IIAR1r1 I)(. Illr rh.IrJrlrrvrrtn -d r1~Jnr1[ sln,Lr
(.urrl0 ,rwdrrlQ I,n.!u, I, ,uul Irn r,~nyl.tnr,n In ,mlr 'r,-
(lue~rurtd +n I l'.y-r I,IIJY .II1J!,\If Rrllr 1.,'.,.'
tthunq ~ Ili-1:1. 1970
(:nsltna, R1~. I.s+s1111R I'J:\ ,rnullsr nlrth,d 6,r Ih«
nrlnJUnn nl +,rl.rashrm,qluhln In a lin~ty I+urI
bl~.,<1 Hr J hid Mrd :: IS9-la1 ;.
r Hn+ lalt rtL. Ilt%` tt! E-,tud:[s ol
u,lnq rJdlnsolopl,a:Is iJbel!n! , ,..~ncr:i,+r-., i~~ .
tlt[ prrpdrJ'lon if rJtaunoli'picJl; iJ'x.:n~ .I6zJr-,-, F. .
IJhJlf~nahunQ 7 !t.-!tl i:,'i
I.l.,. (.I \!. (,: st)l ;( 1\ 1cvR JR .. .~ il . . . » .. . ~
nr,n« as a n+nrJJruc:.,r rratr frn >r-
,. ^n.sl.,QrJC..'1 C .rn.r ,s s -i ~r.r,rr \:~ n . k-.: , ,
\n Rr, Rrs:..r tl., v rr'-7''.-
P", R P \1.'1R t ( rR^/1 \ r .r.
Rr.rIJ, r, ,,: .r . _ar,.i,r -.
Ib'n
OI Itllt.r PI) I!,[ iltnlfnJn([ \'.r.
L.r~J:.rtlnn (.rrnnr.c/a..n 1I,I,n.r \!(.
/rrt IR tds 1t t rrrls rn: , rtr,
tl !:... !! . . ~ .. . ..+ , !, 1: ... tr. (. r . .. ~ . ..
rr . . ,, °-t._
r . . . (. ~.:'-,rr.,rt -I 1Le :un~t d
1, .. . .. H r.r hi t I ~
i ' . 5! . -,r. '. r . , .I '\ J' ":.,rn. . ,-rni 1i rnJr wr1, r:,rt ,,, nl( rlr^,J..
.J ., .
~ . .. . . , . w i.... . .,, rrli^1J1 rrrrl ", .L Ff f ! `
,.il,! .,1~", ^rl i 1:,
rn ,rr:,,lr flnm 40% r~h.urn !,.. -lu.r !(.ri, II t' F x~)
F:..~ ,f :.+rsnt ,r !ru~i ~'! s, .Ji Crrd ,hwrnr( ,inOr r-,ld (rb/,-, L,.lp 'Inrd b. _ .~.Ir ~
, . . .. . .
,.i...,n. ;I,.m ,nC t.~rm~n~ n.~tm.u ti+l+hrll.nn 'S ..1 .,1 ra!.,,inr lu .rr."Lr Ir-1 (li
rd,.l~rrr n-
11 t F .
F:.: vr :i n! IJr.na at !r.ri nf 1n.~J1 r~nd. %hn..~nQ Jn,iL.lr.(nld fihnn+t I.~i,l, I+nrd M I-
..I. rld,.r,
.rl,,Jrn ~ rlli:r.':r {2, J,(r: ,c,utlr(~ , .~.lmnu, rl,lrhrL,, rrn hrlv. miid h.i.rlr;.nlJ
nl
..,I ,.r Ir.i11 i~ E 7i
F: .r `..rnnt .lt !..~! vl 1'H,I .nr ~. ,hatnl( lu!-i.rn1J Irnrd h, : ru 7 '11;rrpiJ,rir
,n.rlifnvl r, :.i.,. .,
i,lll:rn~ra ,rrl:. lr Irnm SU: I.- I, ' II Jc F. ,
F.,. R! -lr, !:~n .d IJr~It ,' r i d lurJl hnrlnr hs!.~rlrrn I . .n'I JIJ +Jt, Inn~nd rrt
,m . II l F 'S
vr ,nrp"l~ .r ,I,n~rnurtl r.liil .,I.rrhr,.+i.
m- ,r, II \ E I'
F:, kr - -wr'~ ~. -i s .,-nQ r.r-~~Ilnnt.rlni, 'n n,~t
I-I ; % , . - "
CT ) 'r I ) ) 7 0 4 2-7 21/ 1 6 2
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888 Bernteld, Homburger, Soto, and Pal
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CTR f 1f7 04276:"~
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Clyrretto Smoke Inhalatlon Studies In Inbred Hamsters tlE
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