Council for Tobacco Research
Strain Differences in the Response of Inbred Syrian Hamsters to Cigarette Smoke Inhalation Journal of the National Cancer Institute, Vol. 53, No. 4 [St Smoke Exposure Resulted in Reduced Body Weight, Enlarged Heart and Lungs, Hyperplastic or Neoplastic Changes in the Larynx, and Microinvasive Cancer in Hamsters]
Fields
- Master ID
- Ctrmn00041967-2810
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- Author
- Jnci
- Bernfeld, P., Bioresearch Consultants
- Homburger, F., Bioresearch Consultants
- Homburger, F., Boston Univ
- Russfield, A.B., S.T. Vincent Hospital, M.A.
- Bernfeld, P., Bioresearch Consultants
- Depository Date
- 08 Sep 1997
- Box
- 267
- Type
- SCIENTIFIC ARTICLE
- UCSF Legacy ID
- wnt30a00
Document Images
A h
taOAUtTi SStoKL
LYNALATTO4 LY t%'l{0.LD KAKS?LRS
No tumors of the lung parenchytru after smoke
exposure were observed either by Dontenwill or by
us. We did not confirm the slightly significant increase
in adenomatoid lesions observed by Dontenwill. In
both model s)stemi, so-called "smoke cells" increased
in the alveoli after smoke exposure. The observation
that yellow iron-negative and alao black particles
occur in the macrophages suggests that the particulate
phase of smoke reached the alveolar wall to be taken
up by the macrophages. Use of the 2 inbred lines in
our experiment permitted the conclusion that these
cells are not directly related to hyperplastic changes
in the respiratory tract. They werr. much more abun-
dant in the 8IO 87.20 hamsters, which had the lower
!ncidence of hyperplastic lesions.
The tracheal and bronchial papillomas and the
nasopharyngeal tumors (one with clear-cut metas-
tises) obsened in our smoke-exposed hamsters resem-
ale tumors induced by others with nitrosamines (11)
:nd suggest the presence of this clan of substances in
::he smoke from our reference cigarettes. The only
r.itrosamine so far detected in cigarette smoke con-
:ertsates, however, is dimethy)nitrosamine (1?).
xEFERENCES
/) Do.TS.~.nl W, CKCVALaR HJ,.HAttus HP. et a): Ins tes:iQation. on the efttc of chronic
ugarette-smoke tn-
halanon in S)rian golden bamsters. J`atl Cancer fnst
51 1'81-183?, 1973
;t %Vtvou EL, HOrrwAVr D- Experimental tobacco car-
ctnoger.esu A .>,dvanca in Cancer Research (Haddow
(3)
A. Weinhoure S, vol 8. New York, Academie
Preas Inc., 1964, pp 249-253
S[altRLo P, HOMti7ROtR F: Hish nicotine tolerance of
S rian `olden hatsuten. Toxicol .+,ppl Pharmacol
21:324, 1972
(f) HorrNANN D, WvNOSt EL: Chamber developmeot and
aerosol dispersion. /e Inhalation Carcinogenesu tHartna
MG Jr. Neetesheitn P. Gilbert JR, eds.). AEC Symp
Seria No. 18, 1970, pp 173-189
($) ATk1~c70N WO: Production of sample ci`aretta for
(6)
tobacco and health researcb. Tobaceo and Health
Conf, Rept No. 2, 1970, 28
Cotnavs BT. LAwrre[st PJ: A sensitive method for the
determination of tarboxyhae lobin in a finSer pricit
sample of blood. Br J tnd Sted:l39-143, 1965
(7) Kassua G, Laoesr H: Fluorometr{c measurement of
tsiglycerida. ln Automation in Analyticaa Chemucryl
Technicon Symposia 1965 (Skens LT, ed,). New York.
Mcdiad, 1965, pp 341-345
(6) HowswtasR F, Russrat.o A8: An inbred line of Syrian
hamsters with frequent spontaneous adrenal tumors.
Cancer Res 30:305-308, 1970
(9) Wooltsv GW: Tumors of the adrenaJ cortex. !A Ciba
(10)
Foundation on Endrocrioology. 12. Hormone Produe-
tion in Endocrine Turnours (Wobtenhoime GE,
O'Connor M, eda.). bosmn, Little 8rown & Co., 1938,
pp 122-136
DomreN.,tll W: Etrptrimental investigations on the effect
of cigarette smoke inhalation on small laborator7'
animals. lA Inhaladon Careinogenais (Hanna \tC Jr,
Nettesheim P, Gilbert JR, eds.). AEC Symp Senea
No. 18, 1970, p 389-411
(Il) H[.Aot.o KM: Pnduetion of olfactory neuroepithelia)
tumors in Syrian harruten by diethylaitrosarrune.
Cancer 17:11+-121, 1964
( 12) M6CORMIc:R A, NteHOCSON MJ, BArnts MA, et a). Nitro
sarrunes in ci6arette smoke condensate. Nature ;1ew
Etolj 214:237-238, 1973
,
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Fictrne I.-Laryts: of malc 210 15.16 bam.ter ezpn.ed to ci6arette smoke foT 71 wee:ks. Epitbelium
shovn miaimal thickeain:
X.u praniaeat, rquhr laycr of baW ceW. Hertutosylio and eoata (H & E). X 600
Ftcuss 2-H79erpls.is ia laryna of male 210 87.20 hanroter expc.ed to uaols feir 60 weel.. Xar
moderately tbichmed epiderrr;.
rtuaimsUy stypiul audei, and iatact basal layer. H k F- X 800
Frcvsa 3-FouJ 6yperplaaia in Iaryne of male 210 15 16 6 bamuer, eexposed to aatake for 73 vre¢ka.
X.u nurkedly atypical outlc
and intact basal isytt. H t E. X 600
Ftce-Rn 4-Fariy basal cell hypnactiv{ty in laryne of male B1O IS.l6 harrstar exposed to.mok<fot
100 weeka. J'Xw thick epitAeliur
wtth narrv.r tcoe oi superficial keratinuaooe. Downpowth of basal cells witb mitotic activiq and
.ome oucicar atypea; bo-eve:
normal orieotatiao of celb fauly well maiatained. H 8; E. X 400
Ftousts S.-Early basal cell hypetactivity in larynx of male Sf O 87.20 bamuer exposed to.moke for 61
weeks. Basal layer tomewha
irrcrular bvt still intact. .yea stypical nucJe and abnorrnal keradaiaauon in deep «U at ngki. H &
E. X 800
Fict'st 6-Marked bataJ tell hyperactivity in larynx of male 8TO 15.16 harrstn exposed to smoke for
92 weekS Severe hypu
kersto.it and acantbow with nuclear atypu, particulsrly in the basal re8im. N.u re8ular polarisatioo
of baul celli in dee:
cNl oau. H k E. X 250
1152
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1157
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