Council for Tobacco Research
Response of Rats to Pyrolysis Products of Fluorinated Polymers [St Physiological Responses of Rats to Pyrolysis Products Included Diuresis]
Abstract
MUL
Fields
- Master ID
- Ctrmn00041967-2810
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- Author
- Bailey, J.W., Natl Aeronautics And Space Administrati
- Dilley, J.V., Natl Aeronautics And Space Administrati
- Harris, E.S., Natl Aeronautics And Space Administrati
- Warrington, H.P., Natl Aeronautics And Space Administ
- Dilley, J.V., Natl Aeronautics And Space Administrati
- Depository Date
- 08 Sep 1997
- Box
- 267
- Type
- ABSTRACT
- UCSF Legacy ID
- pnt30a00
Document Images
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_ _ ALfTRACfS: Tk'ELFTH At:\tJAL fIUTT::G _ .63
E l. Flr.oride lon Ecoeran .I jrer Jaholorien e/Seceral fk.eraer6314 ,r D.elrarirea. J. V. Dr
t.t1>,
V. 1.. CASrra. Ja., and E. S. H,wttt, l:orthrop Sonioa. Inc. and NASA. Afannol Spaz-
caft Ceatc, Houston. Teass.
l.tala satt were ecposed to atmospbetot of sarfous fluorinated e:hytene compounds or
ltecadooropcopcrc in salalethal conecnttst ions. The irtcseasa in urinary Ouoride a ficr e.Woa+c
to the.se Buorearbon atmospheres sunated that the; wen depraded biolu0es0; to tree
Ouorida Ion. Inhabtioo of these f(uoroearb.~xontainin.- at.nosphexs also produsd a tood-
ente to marked diutsis, and an increased potassium and creatinine eacretion. The onirsk
also e.shibital a serese j)ucosuria for'ri-T2 hr after e:powres to aunospheres oontaioin:
brctrluoropropere or tetrafluoroethykne. These studiz supprst that simpk Iluorituud
alkcocs are biodesrodable and that this can be demonstrated by the increased urinanes-
eetion of Ossvride ion after eaposure. They also e.abibit a rsepbrotoaicity when given in satb
quantias.
Ri Pulmo..oy XirrovrAo/ofr o/Kevrurers Eryoscdro SmoEe. F. Ho%mtrtou, A. B. Rtss-
irto, oad P. BZ.tu~snr, Bio-Researeh Cotssultants, lna. Cambridte, htassaehuxas.
Ot:e hundred and tso inb" S>siao bamsrers of the 910 iy.:0 and D1O 13.16 strains..tx
espo:ed tslor dat7y, 5 Ca>s a.eck, to E pu3s from Kentucly I RI cipreves of=-sec dur~ion
takeo e.ery minute b> aWalton\lorrissey reersr smoker. The e%posu:e to 19.3% seeo:e
eoacentratlon lasted 15 see and .tzs foiJooed by 43 see of Lsboratory air. Suty aniruls of
each serala cere te:d Sa ors witbout raat:)pulation and CO additional co:urel a:iuzls of
each strain were esposed as the espcrinxntal animals e..xpt that noritarcue +u insetted into
the rtnc?siae. la L`e B:O $7.20 stralo anfziais werc killed at dS weeks, and those of the BIO
13.16 stmlo at 43 aLd 78 wakt Anima)s d>ins s;ootar.cotssiy were also studied hir
toleYn i ly. ia lhar.uters exp^sed to s:r ole, nucrophape Gsnu lomas were seen in tts
;.ulmcou>
parr::ch>rv, es:e+riallv fre: ucntly and eari; in 87.20 hstraters. Rarc ma)i fna.i: tumors werc
feumd ir: tce oascp:rl.nx ef smol:c<..posed 15.16 animals. Pnma!iptcr.t d>s;la:t. cL--;es
w ere seen in the lar>ns after approaimately C0 wcet:s of s.no:e es;o;u:e. 1-t si.e neo7u:ic
ehazjes e:rr four.d in the lu>na of smoke<.aposed anirnals of both strains. te^e'nning a: aaout
60 Nec!:s of s-okir; T.:it eonflrms the observa:iom of Dor.t.mtsl: of lar.rfeal charpes an:
Gemans:ra:ca the use!u.tneu cf the hamster inhal_tion modcl far studies en .^..rtinotcnet:s of
M.~.1... : 3Re.
61. Rr:~ove o,r R::r so Pw,af,~sis Pra[rrr:r of Fluori,,errd Pol,-.ers. E. S. H.aaz-
H. P. N:a".e'ro.. 1. W. Dsunr ar.d J. V. Dr_Ln', NASA. Va-_ ed S,^_:ecraft Cc.r:.
Housron, Texs.
A prc.io_s rr.o:: !raes this !abcra:on presented the LD!0 ar.d niersropic ratEa'o;>
rssalti ; fror t:.e e~;osur: of rac; to tha r~rol.sis pr:duns of eo,cl>rnen o'.ln,Ldcne
ffca^Ce aed ~.ac'vr.r ; ex (1) and (1) plus .dd:ti.es Ptodu xd t,> t+'= nanufaeturcrs. Tnis
repuR cst-.rds :cat .,rr: to eaanirction of ph; sioLopnl re:pcr.sas at suNe:t;al le,elt. T`.e
p~zojzis prc,!_::s of all th1ee macen9s p:edusJ marked diare.is and ircreasrd %sarc:
roasLr..s:ene.;.osure. Corcot-r..i::ant s.ith the diu:esis was an ir.r.;ate~ estt`ut
ef f._r.e rar., G:.ec=.ia and iraaW- uri~ary paatsicr.:. ~1a~eTC:rie a.us c! k.x.
s.:c: a's G:`>~ sS,ws an a;,arent _'r.iLitior. trcGuc:d ty all thrce ma:rrias. T1is
.~ascct!oucdwtau.a=a!;:c:ro;hotorn.:nar.etho2.GrusiobunationcittetrJc:~ s~o+s
All ;:oeticm:e:l p:rT_aes retcracd to r.e:s) withi:+ 14 da>s Tn:
osrr_i!p:ct roiaG~t:;(eaima)tuFu!cda^-3:fe))oain~sutlahate.,osuru:otle;~rc';:i,
prcCccs ef :ii t::rce n-.a:erials. ft it r.o: ) e::eruin that t1i: damapr is enriret;dce to
irhatsat,%
of h> L-el;zbte t1u:rl,,c Gur'v+g the c.aposcrt p:riod.
&:. Rrr; i c:rrr Grrrnr:rrr o_/.acrrone anJ .lrrro+aie !e tl:e Def. Jor. L EGLt. Jr.., \le.f,:4l
Col7r;c of Vtr.-inia. Virginia Ccnur.oi+caltl L'nkersi:c. Ri:hr..ond, Virpnia () F.
8orr:r:.r_)
a,`e:cr.c aaJ annrsr.ia a^e amorS the rr.> eo.nfoa..fs nf roai:rlcSiet in:crest fou:.f ir
ttu a;vr phsse of c.~r-:es:e smo:e. This s:udy deals with the handl~S j of these onr..pounG, tn
r~\
CTR CCNTRACTS 00570~
11225444 '
CT R. M N 04 2- FE 5" S A t-E-5
